Daily Archives: June 11, 2022

Doctors working on an experimental cancer treatment were heartened when every single patient in a small trial went into remission, their cancer becoming undetectable.

Published in theNew England Journal of Medicine, the paper that resulted from the trial details how all 12 patients who were given the experimental rectal cancer treatment went into remission without having chemotherapy.

"I believe," Memorial Sloan Kettering (MSK) Cancer Center scientist Luis Diaz Jr told the New York Times, "this is the first time this has happened in the history of cancer."

As an MSK press release about the study describes, study participants were treated to an incredible surprise when, after undergoing six months of the experimental immunotherapy treatment, they learned from their doctors that they were in remission.

The first patient, named Sascha, was preparing to travel to New York to have radiation therapy when she got the call from her oncologist, Andrea Cercek, who said the patient was "stunned and ecstatic" at the news.

"Its incredibly rewarding," Cercek said in the press release, "to get these happy tears and happy emails from the patients in this study who finish treatment and realize, 'Oh my God, I get to keep all my normal body functions that I feared I might lose to radiation or surgery.'"

The MSK doctors behind the study wanted to investigate whether immunotherapy alone could treat cancer, but they never expected it to work this well and especially could not have foreseen that none of the 12 people in the initial trial had adverse reactions to the drug, known as dostarlimab.

Dostarlimab is a checkpoint inhibitor, which "releases the brake on an immune cell, freeing it to recognize and attack cancer cells,"according to the team.

The finding is intriguing, but unlikely to represent a miracle cure. As the NYT cautioned, an average one in five people who take drugs like dostarlimab have an allergic reaction, and as many as 3 to 5 percent have severe reactions that include muscle weakness and trouble chewing and swallowing.

Dr. Alan Venook, a University of California, San Francisco colorectal cancer specialist who wasn't involved in the study, told the NYT that the lack of side effects means that "either they did not treat enough patients or, somehow, these cancers are just plain different."

Venook is not alone in his caution about the results. The trial was small, with only 12 participants, and has yet to be replicated.

In an editorial published in theNew England Journal of Medicine in tandem with the initial study, Dr. Hanna Sanoff, a gastrointestinal medical oncologist at the University of North Carolina who was also not involved in the study, wrote that the "small but compelling" trial needs more time before doctors can fully understand the results.

"Very little is known," Sanoff wrote, "about the duration of time needed to find out whether a clinical complete response to dostarlimab equates to cure."

All the same, these unprecedented results are clearly pretty exciting for doctors and patients alike.

READ MORE:Rectal Cancer Disappears After Experimental Use of Immunotherapy [Memorial Sloan Kettering Cancer Center]

More immunotherapy:Scientists Complete First Human Test of Vaccine Against Brain Cancer

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Scientists Intrigued by Treatment That Put Every Single Patient's Cancer Into Remission - Futurism

That's one way to do it!Crown Car

It was a big weekend for the United Kingdom's Queen Elizabeth II, who marked her astonishing 70 years on the throne the longest of any English monarch with an extremely British Platinum Jubilee celebration.

Due to her advanced age, Her Majesty was unable to jubilate IRL amongst her adoring subjects. But in a surreal display of absolutely unmatched energy, the longtime ruler did journey through through the streets,sort of via hologram, beamed into a historic 260-year-old golden carriage. Naturally.

Drawn by eight royal horses, the "hologram" featured archival footage of a smiling young Queen during her 1953 coronation ceremony, riding to Buckingham Palace in the same notoriously uncomfortable Queen-mobile, which has been used for every coronation procession since its commissioner King George III first took it for a spin in 1762.

As Gizmodo pointed out, it wasn't quite a hologram in the sense of a full 3D projection like in "Star Wars," although it was the same technique that resurrected Tupac Shakur at Coachella back in 2012 and seemingly the same trick used by Kanye West to gift his then-wife Kim a birthday message from her late father in 2020.

Regardless, such a public marriage of the old world and the new is fascinating, especially from an organization as traditional as the English monarchy.

In any case, if the carriage ride is as unbearable as the Queen says it is, we don't blame her for sending a hologram instead.

More on holograms: Man Married to Hologram Can't Talk to Wife Due to Software Glitch

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The UK Is Apparently Just Driving Around a Hologram of the Queen Now - Futurism

That's one way to do it!Wacky Hijacks

Russian space agency Roscosmos is struggling to keep operations going after the country invaded Ukraine, greatly distancing itself from the rest of the international space community in the process.

Russian scientists are now trying to gain control of a German telescope currently orbiting the Earth almost a million miles away, Ars Technica reports,in a bold escalation.

The Russian-built Spektr-RG spacecraft was launched by a Russian Proton rocket three years ago. It houses its primary instrument called eROSITA, an X-ray observatory built by the Max Planck Institute for Extraterrestrial Physics (MPE) in Germany, as well as the ART-XC instrument, a Russian high-energy X-ray telescope.

But ever since Russia invaded Ukraine, Germany cut off its cooperation with Roscosmos, forcing eROSITA into safe mode on February 26 to the dismay of Russian authorities,who now seem to want control of the instrument back.

Now, outspoken Roscosmos chief Dmitry Rogozin is planning to take control over the telescope.

"I gave instructions to start work on restoring the operation of the German telescope in the Spektr-RG system so it works together with the Russian telescope," Rogozin said on Russian state TV, as quoted by German broadcaster Deutsche Welle.

"Despite Germany's demand to shut down one of the two telescopes at Spektr-RG, Russian specialists insist on continuing its work," he added. "Roscosmos will make relevant decisions in the near future."

German officials are now warning that turning on eROSITA without the involvement of the MPE could potentially cause damage, Deutsche Welle reports.

Rogozin is furious at Germany for halting the Spektr-RG spacecraft's operations, and is clearly not above slinging mud in the ensuing conflict.

"They the people that made the decision to shut down the telescope don't have a moral right to halt this research for humankind just because their pro-fascist views are close to our enemies," Rogozin said during his appearance.

What Russia's forceful intervention will mean for the future of the observatory remains to be seen. One thing's for sure, though: don't ever bet against chaos in the Russian space program.

READ MORE: Russia seeks to hijack German telescope on its X-ray spacecraft[Ars Technica]

Read more:
Russia Reportedly Trying to Hijack Space Telescope Currently Orbiting Earth - Futurism

Jun 09, 2022 | 13:40:22 IST Chopra takes forward her Bulgari ambassadorship in a hard-to-miss Robert Wun number

Its been a hot minute since the Quanticostar donned an orange sequin Rasario gown for Bulgaris Jewelery Gala in Paris. While Chopras fascination with shimmer and sequins is the thing of dreams, it was outlived by another of her extravagant, bold looks that she has been opting for lately. Robert Wun, known for his inventive, cutting-edge designs that celebrate the female form, unveiled an ethereal contrast gown where fashion collided with futurism. Be it the masterful juggling of shapes and forms, or the razor-sharp contrast of black and white the contrast dove gown taking over the internet. While on one hand she left fashion enthusiasts stunned with this sartorial statement outfit, on the other hand, Instagram was flooded with a thread of memes relating the gowns resemblance to that of pencil shavings. Either way, the Priyanka ChoprasRobert Wun gown was undoubtedly a conversational piece to begin with. Scroll down to know the details of her look.

Chopra, in collaboration with her long term stylist Law Roach, donned Robert Wuns statement floor-grazing number featuring asymmetrical, dramatic white ruffles layered over a black fitted bodycon dress. The contrasting details blends flawlessly with the softness of the pleated elements, enhancing Chopras hourglass shape. Similar to her previous Rasario number, Chopra veered to her usual plunging neckline. With a sensuous tie-up detail at the back, the halter-neck gown was styled with an emerald embellished Bulgari necklace and earrings.

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Priyanka Chopras Robert Wun number oscillates between intriguing realms of futurism and fashion - VOGUE India

The summer is finally going to the movies. The Jurassic dinosaurs are about, Lightyear is next and Elvis isn't far behind. I'm looking forward to Jazz Fest with loads of New Orleans music when it expands next week beyond that one theater in Toronto.

Meanwhile, we have these

Jurassic World Dominion: 3 stars

Our award-winning journalists bring you the news that impacts you, Canada, and the world. Don't miss out.

Hustle: 3

Neptune Frost: 3

The Janes: 4

The Shepherdess and the 7 Songs: 2

JURASSIC WORLD: DOMINION: There's too much here. This is not only the longest of these Jurassic films, the 6th in the series by the way, its got action that keeps on going and going. One encounter with these modern-time dinosaurs will come to a heart-pounding climax, and another starts up. Survive a truck that's rolled; a plane that's chewed, and something else happens, and then something else. It feels like Colin Trevorrow, the director and co-writer, threw in everything he could think of. It's not that it becomes tiring to watch, it's too exciting for that, but it loses credibility. You can see how it was built. And that undercuts the environmental message, that one character states like this: We act like we're alone here, but we're not.

The early going is most effective. Dinosaurs now roam anywhere (they were released last film). They don't terrorize cities like a Godzilla. They just live in the woods and don't bother you, unless you get too close to a mother's baby or encroach on their habitat. But there are poachers and a black market, illegal breeding, even underground dogfight-like shows. Characters from the first film (Laura Dern, Sam Neill, Jeff Goldblum) come together again to investigate. Others from later films (Chris Pratt, Bryce Dallas Howard) are back too. Chris pets a small dinosaur like a pet dog and in a great scene filmed near Kamloops, B.C. ropes a big one like a cowboy. Also back is a guy who was minor in film #1. He's now played by Campbell Scott and heads up the genetics developer BioSyn which started this dinosaur revival in the first place. They're now breeding locusts so they can sell farmers a special pesticide. They want to control food production all over the world. That takes the story into comic-book territory.

Teenager Maisie Lockwood becomes a prime target for reasons too complicated to explain except that BioSyn deems her the most valuable intellectual property on the planet. Much of the action is to keep her safe. But connecting all these story lines is shaky at best. The work of scientists is judgedone has regretsand who knew the CIA has a Dangerous Species Division. Don't think about it. Dig the sights in several countries and the action. (In theaters everywhere) 3 out of 5

HUSTLE: Adam Sandler has a spotty record in his movie career but don't pass up this one. It's bright and lively and you don't even have to be a basketball fan to enjoy it. Fans will be extra delighted though because it's adorned with men from the sport they'll recognize. Men like Shaq, Seth Curry, Dirk Nowitzki, Allen Iverson, Charles Barkley (now a broadcaster), coaches and even owners, like Mark Cuban. And a lot of current players. LeBron James is a co-producer and probably used his status to bring them in.

One of them, a journeyman named Juancho Hernangmez, currently with the Utah Jazz, plays the second lead, a Spanish kid that Sandler, as a scout, finds and wants to recruit for the Philadelphia 76ers. But Ben Foster, as the owner and son of the original boss (Robert Duvall) blocks him out of spite. The drama shows Sandler's efforts anyway, culminating in an event that apparently is bigger in football than in basketball - a caveat that is for the more knowledgeable. The film is perky, with a snappy pace, thanks to Jeremiah Zagar's direction, and has all the drama you need in these movies with a sports theme. It's light but fun. Queen Latifah plays Sandler's wife and Heidi Gardner is the owner's sister. (Netflix) 3 out of 5

NEPTUNE FROST: Here's a blast against colonialism and exploitation in Africa that comes with a huge imaginative drive and lots of music. It's by Saul Williams, a poet, rapper and actor from the U.S. , co-directing with Anisia Uzeyman, from Rwanda, and it speaks to almost anywhere on the continent. In fact, it was filmed in neighboring Burundi. It's got high and low technology, Afro-Futurism and a very strong voice but says its most pungent words in song. We are not hidden. We are ignored, the film says through one character and with a dream-world of lights and graphics that comes on now and then. I was born in my 23rd year says a narrator. That's when she came to realize what was going on. Men are forced to work as miners, what they dig up goes into iPhones and modern technology, but few who use the devices know that. An authority controls the country, puts down student demonstrations and keeps the men working.

Along with imperialism, the film attacks homophobia. The main character, Neptune, appears as a man at first (played by Elvis Ngabo) and then as a woman (Cheryl Isheja). She connects with an escaped miner (Bertrand Ninteretse ), first in dreams, then for real, and their protests join up. There's vibrant music, with drums throbbing and the film is invigorating in both sound and its visuals. And there are Canadian connections - the Indigenous collective A Tribe Called Red helped produce it. Ninteretse, who goes by the name "Kaya Free" has been living in Regina since then. And according to one character most of the mining companies digging in that part of Africa are based in Toronto. Maybe, but the Russians and Chinese are busy too and the film is a loud, tuneful middle finger. (In two theaters now: Vancouver's Cinematheque and Regina's Mayfair and Toronto next month) 3 out of 5

THE JANES: Once again. Absolutely timely. While we wait to hear whether Roe vs Wade and the right to legal abortions will be reversed in the U.S., here's a stunning documentary about the issues. It's history but could be current. And it's candid and passionate. It's the story of a group of women in Chicago, 50 years ago, who provided abortions because they saw the need. If not them, organized crime would have, and did. Graduates of the anti-war and civil rights movements, they recognized that women deserved rights over their own bodies. They found a few doctors, advertised in alternative papers and on bulletin boards to Call Jane and helped women get the procedure. Chicago, one of them recalls was a town where people did stuff.

They have gray hair now and wrinkles but their stories in new interviews are compelling and they tell them with pride. They had a philosophical obligation, one says, to disrespect a law that disrespected women. That attitude runs through all their stories but so does the tension of what they were doing. Security and secrecy where crucial. A big setback came when they found out that one of their doctors (the most adept at abortions) wasn't a doctor at all. In a new interview he talks candidly and doesn't apologize. But the women had to adjust: they started performing the abortions themselves. Eventually they were found out and arrested. They state their case though. The need was there: 11,000 abortions over five years prove it. The film by Emma Pildes and Tia Lessin debuted at Sundance.(Streaming on CRAVE) 4 out of 5

THE SHEPHERDESS AND THE SEVEN SONGS: It's a sociological study, an ethnographic examination, a fairy tale and a rich drama about women's rights in rural India. At least a part of it, just outside the disputed region in the north, Kashmir. It plays like a folktale, and in fact was written as such by the renowned author Vijaydan Detha. The feminist theme is illustrated by the story of one who has few rights and asserts her power through subterfuge. Laila was won in a test of strength by a man visiting Kashmir, coerced into marrying him and then taken to his village.

It's a sin to be born beautiful in a poor society, she's told. We see why. The local station master (i.e. police) comes on to her. Her husband doesn't notice. The cop's deputy comes on too and she tricks them all. Three times she arranges a tryst with the deputy but each time contrives to bring her husband along. It's not only a trick against the one guy but also a test to see if her husband is strong enough to protect her. Above all it's a sign of how clever she is. And it seems timeless: originally it feels 100s of years old. Then a truck drives by. And there are news reports about protests in Kashmir over a new government law. The film it turns out is absolutely current. The presentation is archaic but the songs propel it and Navjot Randhawa as Laila is endearing. (Art houses including Cinematheque Vancouver) 2 out of 5

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MOVIES: Jurassic World, too much, Hustle, a good one from Adam Sandler and Neptune Frost, Afro-Futurism and anticolonialism - Canada's National...

Who doesn't want to know every nook and cranny of the Moon?Singular Focus

There's now a map of the Moon's surface more detailed than any that came before it.

Published in the journal Science Bulletin, researchers from the Chinese Academy of Sciences, the country's Institute of Geochemistry, and other organizations compiled known information about the Moon's surface in a recent study that includes this wildly-detailed map of the lunar terrain.

As the study notes, the scale of the map is an incredibly precise 1:2,500,000 scale that highlights all known rocks, craters, basins, and structures on the Moon's surface.

Though this is far from the first lunar map, it is the researchers behind it say it's the most detailed yet. To get there, they sifted through lunar geology data from the better part of the last century to achieve the map's stunning scale, featuring a total of 90 different types of structures highlighted on its color-coded key.

As the researchers note, there are partial maps of the lunar surface that are double the scale of this one (eg, ones that are 1:5,000,000), but this map is the first to date that logs the entire surface of the Moon at such a high scale.

Even as the US, China, and Russia are engaged in a three-way space race amid political tensions, this map which was built using lunar surface data from all three countries and some from others as well serves as a testament to the unifying power of science.

That, and to how freaking far we've come in lunar studies.

READ MORE:The 1:2,500,000-scale geologic map of the global moon [Science Bulletin]

More on the Moon:NASA Says It's a Priority to Investigate Strange Domes on the Moon

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China Publishes the Most Detailed Map of the Moon Ever Made - Futurism

Too few of us stop to consider the environmental actions of seemingly small decisions we make throughout the day. For instance, hundreds of millions of plastic straws and billions of plastic forks, spoons, and knives end up in landfills every year, according to research conducted by Habits of Waste, a nonprofit organization focused on reducing our consumption of single-use plastic.

Thankfully, the world is beginning to wake up to these realities, and companies have been created with the express purpose of making eco-friendly versions of products we rely on every day. One way for companies to achieve this goal is by using sustainable materials like bamboo. Bamboo grows quickly,doesnt require pesticides or fertilizers, and is stronger than steel in some instances. If youre attempting to make your home more environmentally friendly, the bamboo gear below is a great place to start.

Key Selling Point: A sustainable planter for your personal garden.

Maintaining an indoor garden is a great way to relieve stress, and even save money if you choose to plant herbs or small vegetables. Hamanas Bamboo Frame is a sustainably made base that can hold your plants and soil. This eco-friendly habitat is long enough to hold a mini row of herbs, and comes in three colors: natural, white, and walnut. Hamana also offers an inner tray, grow kits, and other accessories to help you get started on your indoor garden.

Key Selling Point: This sustainably made mattress has all the same performance characteristics as more wasteful options.

Oftentimes, youre faced with the choice of prioritizing sustainability or performance, Best Choice Products mattress proves this isnt always the case. Its 12-inch thick mattress is made from a mix of bamboo charcoal, which is naturally moisture wicking, gel-infused memory foam, and an anti-odor green tea layer. This combination of materials makes the mattress a great choice for sleepers who run hot, or live in warm climates. Best Choice Products includes a non-slip mattress cover, too.

Key Selling Point: This hoodie is available in 12 sizes, six colors, and is made from 100 percent recycled cotton.

Girlfriend Collective went hard when pushing the bounds of sustainably made clothing in introducing its bamboo hoodie. The machine-washable hoodie is 100 percent biodegradable: its made from 50 percent reclaimed cotton and 50 percent organic cotton grown without pesticides. The company says that by using this material, it has conserved 371 gallons of water, prevented 1.12 pounds of CO2 from being released into the atmosphere, and saved 1.99 kilowatts of energy. All these sustainability features are found in a fashionable hoodie designed to fit any body and any wardrobe.

Key Selling Point: Both the toothbrush and box are 100 percent recyclable.

Youre probably going to replace your toothbrush a handful of times per year, so you might as well get one that wont sit forever in a landfill. This one from PlantX has a bamboo base with charcoal-infused bristles, both of which are BPA-free. It may not have the same fancy features as an electric toothbrush, but you wont have to worry about replacing batteries, mechanical failure over time, or consuming microplastics.

The future of the planet is largely dependent on multinational companies deciding to substantially change their business model and means of production, but that doesnt mean individuals should abdicate their responsibilities. Switching to bamboo products may not save the world, but if tens of thousands of people change their buying habits, companies may change their tune. At the very least, you can know the decision you made helped support a company thats doing the right thing.

This post was created by a non-news editorial team at Recurrent Media, Futurisms owner. Futurism may receive a portion of sales on products linked within this post.

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Ditch the Plastic and Cotton for These Bamboo Picks - Futurism

That's... messy.Wire Cutter

A Tesla Cybertruck prototype made a rare public appearance during the commissioning ceremony of the car company's Megapack project in California, now one of the largest battery energy stations in the world.

But the prototype left a lot to be desired. The interior appears to have been stripped of several components, including the wheel-mounted airbag and the front-facing camera enclosure, as seen in images captured by local news station KSBWthat show loose wires hanging out of the vehicle's futuristic yoke-style steering wheel.

While we should expect a prototype to have a couple of rough spots here and there, it doesn't feel like the company went out of its way to make the vehicle presentable, especially given the rather ceremonious occasion.

It's also worth mentioning that it's not even the first janky prototype Tesla has actively chosen to show off to the press.

We did get a glimpse of the center console of the upcoming truck, and its sleek instrument cluster. We also got a detailed look at the truck's gigantic windshield wiper, which seemingly has been pared down significantly in size since the last time we saw it.

Tesla did have to push back the delivery date of its brutalist pickup to next year, but it's already June and the clock is ticking. In fact, production was meant to have started by this point, according to promises made by Tesla CEO Elon Musk last year.

The Cybertruck was meant to be Musk's pet project but from what we've seen so far, those who have preordered a truck of their own will likely have to be even more patient as the company focuses its efforts elsewhere.

READ MORE: Tesla Cybertruck with updated interior and windshield wiper goes on new outing [Electrek]

More on Cybertruck: Cybertruck Prototype Mocked for Looking Extremely Janky

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Tesla Shows Off Cybertruck, But There Are a Bunch of Wires Ripped Out of the Steering Wheel for Some Reason - Futurism

As promised last week, let us explore opportunities for young people, focusing on rural futurism. On day one of the Okere Summit, I noticed something peculiar. A missing demographic component.

We had been entertained by primary school children and adolescents, seen the much older and elderly women in their civic education class, and also interacted with middle-aged community members and leaders at the summit.

Where are the youth? I asked. It is interesting to note that contrary to popular narrative, youth do not constitute the majority component of Ugandas population. But it is easy to tell when they are or arent in a place. Futuristic community projects with the potential that Okere city has must integrate youth in their agenda of change, otherwise it is likely to come to naught.

This is for two core reasons. The first being a need to create transitions, and the second being, as a deterrent against the potential for destruction thanks to the hubris, naivety and myopy of youth. That is why I was keen to find out where the citys youth were.

Okere, like many other rural places around the country, is losing its young people to urban migration, in search for better opportunities. There is little to do in the village and their dreams whatever those might be wont be fulfilled there. So, they come to town to ride boda-bodas, work at construction sites or as Askaris, cleaners, hawkers etc. If this fails, as is often wont to, they might resort to petty and sometimes violent crime.

Besides its value in oil, the Shea tree is also, apparently, famous for producing the best charcoal. Before Ojoks foray down this inexplicable dream, whatever little came into the Okere economy was via charcoal trade.

Now, leaders are talking about bylaws to criminalise the cutting of shea trees because they are already reaping more than they ever have and cant begin to imagine the kind of rosy future they will soon have.

You get the sense that Ojok will not be the last son of the soil to commit class suicide. Soon, many others working high level jobs in Kampala or wherever will want in on the harvest. But it wont be just them. It will also be those who didnt get a good enough education and exposure to imagine what more they can do with the tracts of land their families own. They will be back home planting Shea trees on every inch of land that they can find.

If this happens, might we see millions of other young people from other parts of the country decide to swap Kampalas meagre salaries and exorbitant rent bills for their familys cattle farms, coffee, and matooke, and potato plantations?

Might we then be able to bring a stop to the sad sight of labour migration that we continue to witness with hundreds of thousands of our young people seeking opportunities in the Middle East? Who knows!

But these sorts of monumental systemic shifts take lots of guts, endurance and a certain simplicity that not many of us are blessed with. Community impact projects arent the kinds many would invest in because there is usually little to no return on the money. That is why Ojoks move is great because it combines impact with economics that actually works.

More than anything, it is a lesson on how to not over-complicate things. Development and ideas fail to take off or arrive because we start to draw linear demand and supply curves, overanalyse profit and loss margins, try to make forecasts and predict bottom lines. It is the reason why many of us dont start because like government bureaucrats and Ugandan bankers we are looking to tick every box.

But those sorts of things dont tell you that opportunity is more transcendent than linear. That you can just start without a plan and figure things out as you go. That sometimes, your only job in the equation is to begin and let others who wouldnt, take over the planning and strategy because that is their forte. That more times than not, you have a better shot at success if you build off of the work and sweat of your ancestors than you will trying to go at it on your own, in the city. Visit Okere City, it will make sense. Then go back to your village and see what you can do.

Mr Rukwengye is the founder, Boundless Minds. @Rukwengye

Originally posted here:
We tie on Kampala for nothing but future is actually rural - part 2 - Monitor

Science fiction has never been quite like this.

In Season 3 of the critically acclaimed alternate-history series For All Mankind, the Apple TV+ series jumps ahead to the 1990s, creating a jarring kaleidoscope of retro-futurism and technological anachronisms. As series co-showrunner Matt Wolpert tells Inverse, You've got Bill Clinton running for president, and you've got a hotel in space at the same time. What world is this?

Because of the meticulous groundwork laid by its two previous seasons, For All Mankind suddenly feels like a very different show. Heres why series co-creators and showrunners Ben Nedivi and Matt Wolpert say Season 3 is so unique.

For the first time since For All Mankind began, the focus of the entire series has shifted away from the Moon. Instead, its all about the Red Planet.

In the shows alternate timeline, the space race didnt end in the 1960s. In Season 2, seeing a huge moonbase called Jamestown in the 80s was a novelty, but it also technically seemed possible. In Season 3, the technological differences between the 90s we remember, and the alternate history of the show are more staggering than ever.

In the very first episode of Season 3, Polaris, a fully functional commercial space hotel managed by Karen Baldwin (Shantel VanSanten) is orbiting the Earth in the year 1992.

It's not that it would have been possible in the actual 90s, Wolpert says. But it would have been possible in the alternate history version of the 90s.

Edi Gathegi as Dev Ayesa, founder of a commercial aerospace group, Helios. Apple TV+

So how does that work? Wolpert explains that because so many resources have been put into developing technologically, things got figured out earlier than in our timeline. In this version of 1992, private companies are producing their own spacecrafts. Wolpert likens this to whats happening in the private space industry today.

You see how fast and expertly SpaceX can fabricate their rockets now, he says. With Season 3, its a mashup of the past and the future.

Although the race for Mars is the biggest superficial difference in For All Mankind Season 3, the other new wrinkle is that its not just about the U.S. versus the U.S.S.R. anymore. In Season 3, tech mogul Dev Ayesa (Edi Gathegi) throws his ring in the hat with an independent aerospace group called Helios. At first blush, Dev is very much a cipher for Elon Musk, albeit one who exists several decades earlier in an alternate timeline. But its not that simple.

Everyone always says Elon Musk, co-creator Ben Nedivi says. Dev is a reflection of many different people. Steve Jobs. Jeff Bezos. Theres a commonality with a lot of these tech leaders. But outside of that, our inspiration was more about changing things up a little bit.

Up until Season 3, the basic conflict of everything thats happened on For All Mankind has been framed by a protracted space race. Along with producer Ronald D. Moore, Nedivi and Wolpert felt like it wasnt realistic, to continue to have the show focused on the U.S. versus the U.S.S.R. So they used history as their guide.

The 90s was when tech exploded, Nedivi says. So, it made sense that in a world where the space race was such a big deal, one of those 90s tech leaders would dedicate their resources, time, and energy toward the space program.

The NASA mission to Mars in For All Mankind Season 3.Apple TV+

Jarring and fascinating anachronisms have become a staple of For All Mankind. However, its not actually why the show works. Instead, just like with the previous two seasons, its the journey of the characters. But, unlike other sci-fi shows, For All Mankind isnt just interested in characters in a vacuum. In Season 3, the show proves its moving toward telling a multi-generational arc about several families: the Baldwin family, the Stevens family, the Poole family, the Rosales family, and so on.

Is For All Mankind simply One Hundred Years of Solitude as alternate history sci-fi? In Gabriel Garca Mrquezs masterpiece, the reader sees how each generation changes because of what the characters do in each chapter.

We reference that book so much, Wolpert explains. Theres the idea of generations in that book, and how the children are impacted by the choices of their parents. And were seeing that now more with Season 3.

Casey W. Johnson as Danny Stevens in For All MankindApple TV+

The most obvious examples of this in Season 3 are Danny Stevens (Casey W. Johnson) and Kelly Baldwin (Cynthy Wu), each a second-generation astronaut or scientist, in a family who, at this point, we know very well. There's this evolution of society, and seeing that through a character and family was definitely an inspiration for us, Wolpert says.

So just how many generations are we going to see? Nedivi confirms that a seven-season arc is still the loose plan, and that, eventually, the timeline of For All Mankind would surpass our own. But, that doesnt mean they have every story detail set in stone. In Season 3, there are a few babies and very young children related to the main characters. Does this mean these characters could be grandparents in Season 7?

Yeah, we have to be careful about that, Nedivi says with a laugh. Like every character, we came up with that was a child, we're like, wait! This could be a series regular and a future season! It definitely makes things a little more tricky with the generational aspect. But I think part of the joy of writing the show and what makes it so unique on television is that were able to tell the story of people's entire lifetimes.

For All Mankind Season 3 is streaming now on Apple TV+

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'For All Mankind' Season 3 changes the show in 3 huge ways here's why - Inverse