Daily Archives: June 7, 2022

Google, GE, ClearPath have joined a new Princeton research consortium focusing on low-carbon technology – Princeton University

Posted: June 7, 2022 at 1:50 am

Applying academic research to help accelerate low-carbon innovation, Princetons ZERO lab has created a new coalition, bringing together corporations and researchers focused on scalable clean energy technologies. The consortium, aligned with the corporate membership program Princeton E-ffiliates Partnership, includes founding members Google, GE and ClearPath.

Jesse Jenkins, assistant professor of mechanical and aerospace engineering and the Andlinger Center for Energy and the Environment and principal investigator of the ZERO lab, helped design and launch the new consortium with the goal of helping organizations transform their businesses and, in turn, make key energy technologies more commercially viable and quicker to be deployed.

We want to provide practical insights and roadmaps that can support decision-making, guide investment and accelerate innovation, Jenkins said.

The consortium creates an opportunity for big players grappling with a clean energy future to connect.

The consortium aims to help leaders from diverse parts of the energy sector accelerate novel clean energy technologies. Jenkins provided a rationale for why he recruited these first members.

Google was the first global corporation to pledge to match the energy demand from its data centers and officesaround the world with local carbon-free power on an hour-by-hour basis, referred to as 24/7 carbon-free electricity procurement. The company also has a longstanding track record of investing in clean technology startups and using its purchasing power to transform markets for clean electricity.

GE is an equipment manufacturer with a broad portfolio of energy technologies, including on and offshore wind turbines, gas turbines and advanced nuclear power. Through this technology, the company helps generate one-third of the world's electricity. The company is also developing new technologies, such as hydrogen-fueled gas turbines, carbon capture solutions, offshore wind superconducting generators and advanced nuclear with small modular reactors.

ClearPath develops and advocates for clean energy policy, with a focus on breakthrough innovations in the energy and industrial sectors.

Jenkins said the consortium will support two research areas in his group developing models and methods to help inform decision-making and evaluating technologies for economic, environmental and other impacts. As part of its technology evaluation pillar, ZERO Lab researchers are conducting ongoing research on long-duration energy storage, flexible geothermal energy systems, carbon capture and sequestration, and commercial fusion power plants.

One of the consortiums goals, Jenkins said, is to pool funding and maximize the research that can be done in this area when supported by organizations with similar interests. The structure of the program and the flexible funding allow researchers to quickly pivot to tackle the most important and interesting research questions, without having to wait for specific funding cycles or proposal calls from grant-making agencies. It also creates an opportunity for big players grappling with a clean energy future to connect, he said. Jenkins hopes to recruit other members to round out the group, such as a private venture capital group focused on clean energy or the investment arm of a utility.

GE, Google and ClearPath also join thePrinceton E-ffiliates Partnership, the corporate membership program administered by the Andlinger Center. This will allow the organizations to build collaborations with faculty members across a range of topics, including optimizing power architecture in data centers, securing the power grid and transforming waste streams into carbon-rich resources.

The consortium provides an exemplar of the value of collaboration between our E-ffiliates members to maximize the impact of Andlinger Center research. The different perspectives that these consortium members offer improves the quality of the research and enhances the impact of the research for their individual organizations and for the broader national decarbonization effort, said Chris Greig, acting associate director for external partnerships at the Andlinger Center. This has been a key objective of the Andlinger Center and E-ffiliates since their founding, said Greig, who is also the Theodora D. '78 & William H. Walton III '74 Senior Research Scientist at the Andlinger Center.

The collaboration builds on work Jenkins has done with Google, which quantified the electricity systembenefits of 24/7 carbon-free electricity procurement. The research found that using carbon-free, local power can prevent significantly more carbon pollution than purchasing enough renewable energy to meet annual needs, though it comes at a cost premium. The strategy also accelerates deployment of advanced energy technologies, providing a critical niche market to scale up and drive down their cost over time, which encourages full-scale transformation of electric grids.

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Bosses wanting a return to office face off with workers who want to stay home – NPR

Posted: at 1:49 am

Jonathan Pruiett, a geospatial analyst with Cognizant, is part of a team that updates Google maps. They pushed back against a policy that would have required them to be in the office full-time and won a 90-day reprieve. Jonathan Pruiett hide caption

Jonathan Pruiett, a geospatial analyst with Cognizant, is part of a team that updates Google maps. They pushed back against a policy that would have required them to be in the office full-time and won a 90-day reprieve.

To Jonathan Pruiett, it just didn't make sense.

A geospatial analyst who updates Google maps for a living, Pruiett had been called back to his company's offices in Bothell, Washington, five days a week, starting June 6.

Like many on his team, Pruiett had only worked remotely, having started the job in the pandemic. He'd adapted well to it, finding efficiencies such as multitasking during virtual meetings, using the time to process data.

And yet, now he was being told to report to office. Anyone who failed to report within three days of the return date would be processed as having abandoned their job.

"Nothing will change other than having a couple snacks in our office and having an in-person meeting," Pruiett said. "We're kind of starting to think that this job isn't worth it."

More than two years into a pandemic that has no clear end, the debate over remote work has only intensified. Working from home isn't possible in many jobs. But for those who have the option, it's now evident that it is feasible, even beneficial.

But how beneficial is a point of contention between workers and their bosses. Some bosses are deciding too much is lost when people aren't in the office and it's time to come back.

Tesla boss Elon Musk is one of them. He recently emailed his employees with the subject line "Remote work is no longer acceptable." He reasoned that Tesla creates and makes "the most exciting and meaningful products of any company on Earth. This will not happen by phoning it in."

Musk told them anyone wishing to do remote work "must be in the office for a minimum (and I mean *minimum*) of 40 hours per week."

Apple too wanted to bring people back to the office three days a week. But just last month the company decided to postpone its plan after more than 1,000 current and former employees signed an open letter called the plan inefficient, inflexible and a waste of time.

"Stop treating us like school kids who need to be told when to be where and what homework to do," they wrote.

It was yet more evidence of the shift in the balance of power between management and rank and file, as demand for workers has hit record highs in the past year. Companies are finding it hard to enforce unpopular policies and mandates when they fear their workers could just walk away.

The Google maps workers, who are employed by the tech company Cognizant, also decided to fight back. They connected with the Alphabet Workers Union and signed a petition citing COVID fears, the costs of commuting amid $5 gas, and the increase in productivity and morale that employees have experienced while working from home.

With just days to go before the June 6 return to office deadline, Pruiett said he wasn't sure whether he and others would show up in the office on June 6. Members of his team started preparing for a strike vote.

Hours later, Cognizant did what other companies have done in recent weeks: Granted a reprieve.

"Our first day back to the Bothell office full-time will now be September 6," the company said in a statement released on Thursday.

Pruiett called it a 90-day Band-Aid and vowed to continue the fight.

Even as some companies seek to bring back some semblance of office life, others are asking: What is the office for anyway?

At the management consulting firm Eagle Hill Consulting in Arlington, Virginia, the offices have been open since the fall of 2021, but on most days, there are just a smattering of employees on site mostly from IT and human resources.

No one has been ordered back full-time or even close to it. Desks and conference rooms, named after Washington, D.C., landmarks such as the Kennedy Center and Navy Yard, sit empty.

It's a dramatic contrast from pre-pandemic times, when every seat would be full despite the fact that flexible work was offered then, too.

"Could I have worked from home four days a week before the pandemic? I think I easily could have. It just wasn't the environment," says Jason Carrier, a senior associate who used to spend four days a week in the office and one day at a client site.

Although he lives just a few minutes' walk from the office, he now comes in just once a week, which is more than most of his coworkers, he says.

The workforce at Eagle Hill is young, mostly twenty- and thirty-somethings. Before the pandemic, people liked being in the office together. They liked the energy. They stayed late for office happy hours at the end of the day.

Now off-site happy hours are becoming a regular thing alongside virtual bingo nights, thanks in part to Carrier who leads the workplace fun team. So the idea of working from the office, all day, every day?

"Probably very close to a deal breaker at this point," he says.

Eagle Hill's chief marketing officer Susan Nealon says she'd like to see people in the office when it makes sense. She recently took advantage of an in-person event a photo shoot her team had organized to gather a few members of her team for their first face-to-face meeting in more than two years.

"I view the office changing," says Nealon. "It'll be less about the individual work getting done, and more about the group work getting done."

She believes workers may be happier and more productive doing their individual work in the quiet of their homes and only coming into the office for team meetings at optimal times. Instead of fighting rush-hour traffic to sit in the office from 9 to 5, you might just pop in from 11 to 1, she says.

It's an idea that would have been unthinkable just a couple years ago. But already, it's proving to be a selling point for new hires at Eagle Hill.

"It's hard to even fathom going into the office 100%," says Fara John-Williams, who started in human resources in May. "I don't think I could do it ever again."

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Woman left balding and bedbound by chronic eczema clears the condition with a 9 face cream – The Independent

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A call centre operator plagued by such virulent eczema she was left balding, bedbound and slept in a balaclava to stop her oozing face from sticking to the pillow says a life-changing 9 cream cleared her skin overnight.

While Kimberley Reardon, 30, suffered with mild baby eczema until she was three-years-old, it did not flare-up again until her teens and it was only in her 20s that her catastrophic problems began and she was covered from head-to-toe in red raw patches of the dry, flaking skin condition.

For the next decade, her eczema frequently developed into painful, weeping sores and saw Kimberley trying numerous steroid creams.

However, the treatements would work only briefly, before the angry conditionreturned with such vigour she would be unable to move without her skin weeping or peeling.

After several hospitalisations, infections and periods of being bedbound, by March 2022 Kimberley, who lives with her boyfriend of 12 years, healthcare assistant, Scott Hannah, 31, had lost hope only for her mum to stumble upon 8.99 Balmonds Skin Salvation cream that practically cleared her skin overnight.

Kimberley, of Hamilton, South Lanarkshire, Scotland, said: I was exhausted and hopeless. It felt like it was never ending.

I had spent nearly 10 years in chronic pain and itwas an achievement for me to just get myself washed and dressed in the morning.

I have tried so many creams that dont work, so when my mum suggested I tried this one, I was very sceptical about it working.

But, when I woke up the next day, my face was almost clear it was unbelievable.

Kimberley Reardon, 30, in May 2018, before her skin spiraled out of control (Collect/PA Real Life)

Despite suffering with mild baby eczema, her skin complaints only really started in her teens.

She said: My parents would usually use a cream on me as a baby which would work, but then the eczema appeared again when I was going through exams at 15.

It started on my back and spread to the creases in my elbows, with patches of redness.

It bothered me, but it hadnt spread to my face at that point, so I could just hide it.

Kimberleys eczema covering her face and neck in March 2020 (Collect/PA Real Life)

To ease the eczema, Kimberley was prescribed a steroid cream which was steadily increased in dosage to match her increasing flare ups. But hitting 20, the steroid creams seemed to stop working and during the next three years her condition intensified and spread to her face.

Kimberley Reardon, 30, and Scott Hannah, 31, have been together for 12 years (Collect/PA Real Life)

She said: I was studying for my social sciences degree at university, working part-time in a call centre and caring for my grandad because he was poorly and he had pneumonia.

Stress was definitely a trigger for my eczema, which went from some scaly patches to covering my whole body in red, inflamed dry skin that was just falling off my face.

Kimberleys arm was red raw in December 2020 (Collect/PA Real Life)

She added: My arms looked like red sleeves, while my legs were also covered and my neck was incredibly sore.

It was unmanageable. I was trying to use creams, emollients and moisturisers and wrapping myself in bandages, to try and help them to be absorbed into my skin.

Diagnosed with severe and widespread erythema at 23 a rash caused by injured or inflamed blood capillaries, usually in response to a drug, disease or infection Kimberleys skin became worse and worse.

Kimberley Reardon, 30, with makeup on for the first time in years (Collect/PA Real Life)

I wasnt functioning at all, I was exhausted, she said.

I felt ruined, like my body was fighting against me constantly.

It felt like I had severe sunburn over my whole body as if it was burning me from the inside out.

Kimberleys hand raw and peeling earlier this year, in April 2022 (Collect/PA Real Life)

After years fighting the eczema without success, Kimberley felt depressed, although she still tried to go out and have a normal life.

She said: I remember putting foundation on the top of my hands to try and cover the red patches,

One time a woman saw my hand when I pushed the lift button at work and she said, Oh! Have you been burnt? I felt so embarrassed.

I started wearing foundation to try and cover the patches, as well as long sleeves and big jumpers, even in the summer to try and hide my skin.

Kimberleys skin flaking and peeling in September 2020 (Collect/PA Real Life)

I felt so out of control of my skin that I started to micromanage everything else that I could to compensate.

Even though it hurt to move, I was hoovering six times a day to clear my skin up.

I was in so much pain, but I became obsessive about things.

I couldnt leave dishes out and I became totally over the top with cleaning and constantly checking my money, even though I knew I could pay my bills.

Kimberley Reardon, 30, with her boyfriend, Scott Hannah, 31(Collect/PA Real Life)

In 2018, Kimberleys skin condition became so bad she was hospitalised.

She said: My mum took one look at me and was horrified.

Ninety five per cent of my body was covered in red, swollen and burning skin.

I was losing too much fluid through my skin, where I was oozing out.

Kimberley Reardon on March 13, 2022 (Collect/PA Real Life)

She added: And the doctors said I was critically ill. My skin was so weak and I wasnt able to regulate my temperature.

After two weeks on an IV drip in hospital, Kimberley was placed on immunosuppressants and five months of oral steroids, to try and tame her excruciating eczema.

And when 2020 hit, she found herself completely bedbound.

Kimberley Reardon, 30, in March 2018, covering her red hands in foundation (Collect/PA Real Life)

She said: From January to March, my skin was the worst it had even been.

Doctors doubled my doses of immunosuppressants but nothing worked.

I had to have spare sheets to change and lie on every few hours. I was ruining the bed sheets where my skin was so flaky and oozy.

I was spending hours lying in really hot baths, because they seemed to be the only thing that relieved my skin, although it would be worse when I got out.

Kimberley said it was a blessing working from home in lockdown because of the pain and fear of judgement (Collect/PA Real Life)

She added: I was crying constantly and I didnt look like me at all.

I would think, Am I ever going to get better, is this it?'

When the March 2020 lockdown came in, it was a saving grace for Kimberley, as she was able to better manage her pain while she was working from home.

Prescribed new immunosuppressants, her skin briefly cleared but even then, she was plagued with a litany of other side effects.

Kimberley Reardon, 30, struggled immensely with her skin in 2020 (Collect/PA Real Life)

My skin was amazing but I was having other problems, she said.I was vomiting all the time, sleeping all the time and I couldnt keep food down.

Then, in July 2020, her skin flared up again so severely that she was hospitalised once more and signed off work for five months.

She said: I was bitten by an insect, which caused an abscess and cellulitis, a bacterial skin infection, because I had no immunity.

Kimberley trying to get through the pain in August 2020(Collect/PA Real Life)

Kimberley added: I was in hospital for two weeks on a drip again and antibiotics, followed by another three weeks of antibiotics at home.

I was bedbound, I barely got up and my poor boyfriend was carrying me to the toilet and running the bath for me.

I barely got changed, as it would take me hours to get dressed.

I lost my hair from the stress on my head, eyebrows and even my eyelashes.

And I didnt sleep for months because of the pain.

I was bedbound, I barely got up and my poor boyfriend was carrying me to the toilet and running the bath for me

Kimberley tried to go cold turkey without any medication to see if her body could heal itself, but nothing seemed to improve.

My face was covered, my body was covered, she said.

My boyfriend had to care for me, I couldnt do anything.

I spent my days in pain, just watching TV, or I sat in the bath for hours for some relief.

The worst thing for me was feeling like such a burden.

Kimberley Reardon, 30, with her clear skin in May 2022 (Collect/PA Real Life)

In a bid to help moisturising remedies to be absorbed and to stop her skin from weeping on everything, Kimberley would wrap herself up like a parcel.

She said: I was living in my eczema jammies, with long sleeves and long legs.

I would use bandages for my neck and my mum even got me a balaclava to sleep in at night, to stop my face sticking onto my pillows where it wept so much.

Kimberley felt very grateful for the support from her boyfriend, family and friends, but still felt mortified by her situation.

I was so embarrassed, I was completely mortified to be seen, she said.

If I went for a walk, I would just stare at the ground and never look anyone in the eye.

My boyfriend would always be so lovely. Whenever I started to feel bad, he would always bring me straight back up again.

In another attempt to clear her skin, in December 2020 Kimberley was prescribed a biologic an injection which targets the gene that causes inflammation which for three months cleared her skin.

Kimberley Reardon, 30, in September 2020 compared to now, with clear skin (Collect/PA Real Life)

I felt amazing, she said.

I was fatigued and achy from the side effects, but I felt so happy that something was working.

I had my first date night since 2019 at Frankie and Bennys with my boyfriend.

But, just as things were looking up, she developed a fungal infection across her arms and chest in February 2021.

It was so itchy. I was scratching so much I was ripping my skin off

She said: It was so itchy. I was scratching so much I was ripping my skin off.

So desperate to find something that worked, Kimberley even tried cryotherapy the use of extreme cold to freeze abnormal tissue for six weeks in July 2021.

She said: Once a week, I would stand in this freezing chamber, with temperatures at minus 110 to reduce inflammation.

It didnt work, it made me go purple, but I tried it as I was so desperate to do something and so scared of being bedbound again.

Just when she believed there was nothing else left to try, Kimberleys mum, Janey Reardon, 56, a retired receptionist, discovered the 9 cream in March this year.

Picking up a 30ml bottle for 8.99, she handed it to her daughter who cautiously applied some to a small patch on her finger.

She said: There had been no reaction in an hour, so I thought hopefully it would be okay.

I slathered it on and overnight and when I got up, my face was almost clear.

I couldnt believe it.

Using the cream every day, within one week, Kimberley was astounded to see that her skin was still miraculously clear.

And for the first time since 2019, she felt confident enough about her appearance to go to a coffee shop alone.

She said: I had a green tea in the coffee shop and for the first time in as long as I could remember, I wasnt worrying about people looking at my face.I had three date nights that week, one at the cinema and two foodie dates.

Even just going for a walk again was amazing.

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Almirall: Eight out of Ten Patients Maintained Skin Clearance at One Year in Lebrikizumab Atopic Dermatitis Monotherapy Trials – PR Newswire UK

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BARCELONA, Spain, June 7, 2022 /PRNewswire/ -- Almirall S.A. (BME: ALM) today announced topline results from one-year analyses of the efficacy and safety of lebrikizumab, an investigational IL-13 inhibitor for the treatment of patients with moderate-to-severe atopic dermatitis (AD). The new findings from the Phase 3 clinical trials (ADvocate 1 and 2) showed eight out of ten patients who achieved clinical response (EASI-75*) with lebrikizumab monotherapy at 16 weeks maintained skin clearance at one year of treatment with the once every two weeks or four weeks regimen. Additionally, patients treated with lebrikizumab maintained itch relief across the two trials over the one-year period. These results build upon positive datafrom the 16-week, double-blind, placebo-controlled part of the ADvocate program.

"We are pleased to witness how lebrikizumab has proven over a year its potential to be a leading option for the treatment of atopic dermatitis. ADvocate 1 and 2 results add to the exciting, growing body of evidence from our Phase 3 clinical trial program and demonstrate that this medicine may provide much-needed relief for those seeking new treatment options. We look forward to continuing our collaboration with Lilly and advancing in our clinical program, aiming to obtain approval in the European Union," stated Karl Ziegelbauer, Ph.D., Almirall's Chief Scientific Officer.

AD, or atopic eczema, is a chronic, relapsing, heterogenous skin disease characterized by intense itching, dry skin and inflammation that can be present on any part of the body.1-2 Lebrikizumab is a novel, monoclonal antibody (mAb) that binds to the interleukin-13 (IL-13) protein with high affinity to specifically prevent the formation of IL-13R1/IL-4R(Type 2 receptor) which blocks downstream signaling through the IL-13 pathway.3-7 IL-13 plays the central role in AD, promoting Type 2 inflammation that drives skin barrier dysfunction, itch, skin thickening and infection.8-10

In ADvocate 1, 79% of patients who received lebrikizumab every four weeks and 79% of patients who received lebrikizumab every two weeks maintained 75% or greater skin improvement (EASI-75) at one year of treatment. Additionally, 85% of patients who received lebrikizumab every four weeks and 77% of patients who received lebrikizumab every two weeks maintained EASI-75 response in ADvocate 2 at one year of treatment.

The frequency of adverse events and the overall safety profile among these patients treated with lebrikizumab were consistent with the induction phase of the trials as well as previous lebrikizumab studies in AD. No new safety signals were observed in this patient population.

"In these studies, patients treated with lebrikizumab maintained skin clearance and lasting relief from intense itch at one year. We look forward to providing an important new medicine and helping patients find the relief they so desperately seek from the varied and debilitating symptoms of this disease, contingent upon FDA approval," said Lotus Mallbris, M.D., Ph.D., vice president of global immunology development and medical affairs at Eli Lilly and Company.

With these data, Almirall plans to submit a Marketing Authorization Application (MAA) to the European Medicines Agency (EMA) for lebrikizumab in AD in the second half of 2022. Lilly also plans to submit an application to the U.S. Food and Drug Administration (FDA) this year, followed by submissions to other regulatory agencies around the world.

These studies are part of the comprehensive clinical development program for lebrikizumab in AD evaluating more than 2,000 patients. Full one-year results from the Phase 3 monotherapy studies will be disclosed at upcoming congresses and in publications in 2022. Additional Phase 3 clinical trials are enrolling for lebrikizumab in AD.

Almirall has licensed the rights to develop and commercialize lebrikizumab for the treatment of dermatology indications, including AD, in Europe. Lilly has exclusive rights for development and commercialization of lebrikizumab in the United States and the rest of the world outside Europe.

*EASI=Eczema Area and Severity Index, EASI-75=75 percent reduction in EASI from baseline to Week 16

About ADvocate 1 and ADvocate 2 and the Phase 3 Program

ADvocate 1andADvocate 2are 52-week randomized, double-blind, placebo-controlled, parallel-group, global, Phase 3 studies designed to evaluate lebrikizumab as monotherapy in adult and adolescent patients (aged 12 to less than 18 years of age and weighing at least 40 kg) with moderate-to-severe AD.During the 16-week treatment period, patients received lebrikizumab 500-mg initially and at two weeks, followed by lebrikizumab 250-mg or placebo every two weeks. In the maintenance period, patients with moderate-to-severe AD who achieved a clinical response after 16 weeks of lebrikizumab treatment were re-randomized to receive lebrikizumab every two weeks or every four weeks or placebo for an additional 36 weeks.Patients who required rescue treatment during the induction period or who did not achieve clinical response (lebrikizumab non-responders) at 16 weeks received lebrikizumab every two weeks for an additional 36 weeks.The primary endpoints were measured by an Investigator Global Assessment (IGA) score of clear (0) or almost clear (1) skin with a reduction of at least two points from baseline and at least 75 percent change in baseline in the Eczema Area and Severity Index (EASI-75) score at 16 weeks. EASI measures extent and severity of the disease. Key secondary endpoints were measured by IGA, EASI, the Pruritus Numeric Rating Scale, Sleep-Loss due to Pruritus and the Dermatology Life Quality Index.

The U.S. Food and Drug Administration (FDA) granted lebrikizumab Fast Track designation in AD in December 2019. The lebrikizumab Phase 3 program consists of five key global studies including two monotherapy studies, a combination study (ADhere), as well as long-term extension (ADjoin) and adolescent open label (ADore) studies.

About Lebrikizumab

Lebrikizumab is a novel, investigational, monoclonal antibody designed to bind IL-13 with high affinity to specifically prevent the formation of the IL-13R1/IL-4R heterodimer complex and subsequent signaling, thereby inhibiting the biological effects of IL-13 in a targeted and efficient fashion. IL-13 is the central pathogenic mediator of AD, promoting Type 2 inflammation that drives skin barrier dysfunction, itch, skin thickening and infection.6-8

About Almirall

Almirall is a global biopharmaceutical company focused on skin health. We collaborate with scientists and healthcare professionals to address patient's needs through science to improve their lives. Our Noble Purpose is at the core of our work: "Transform the patients' world by helping them realize their hopes and dreams for a healthy life". We invest in differentiated and ground-breaking medical dermatology products to bring our innovative solutions to patients in need.

The company, founded in 1943 and headquartered in Barcelona, is publicly traded on the Spanish Stock Exchange and is a member of the IBEX35 (ticker: ALM). Throughout its 79-year history, Almirall has retained a strong focus on the needs of patients. Currently, Almirall has a direct presence in 21 countries and strategic agreements in over 70, with about 1,800 employees. Total revenues in 2021 were 836.5 million euros.

For more information, please visit almirall.com

Legal warning

This document includes only summary information and is not intended to be exhaustive. The facts, figures and opinions contained in this document, in addition to the historical ones, are "forward-looking statements". These statements are based on the information currently available and the best estimates and assumptions that the Company considers reasonable. These statements involve risks and uncertainties beyond the control of the Company. Therefore, actual results may differ materially from those declared by such forward-looking statements. The Company expressly waives any obligation to revise or update any forward-looking statements, goals or estimates contained in this document to reflect any changes in the assumptions, events or circumstances on which such forward-looking statements are based, unless required by the applicable law.

1Weidinger S, Novak N. Lancet. 2016;387:1109-1122.2Langan SM, et al. Arch Dermatol. 2008;142:1109.3Moyle M, et al. Exp Dermatol. 2019;28(7):756-768.4 Ultsch M, et al. J Mol Biol. 2013;425(8):1330-1339.5Zhu R, et al. Pulm Pharmacol Ther. 2017;46:88-98.6Simpson EL, et al. J Am Acad Dermatol. 2018;78(5):863-871.e11.7Okragly A, et al. Comparison of the Affinity and in vitro Activity of Lebrikizumab, Tralokinumab, and Cendakimab. Presented at the Inflammatory Skin Disease Summit, New York, November 3-6, 2021.8Tsoi L, et al. Journal of Investigative Dermatology. 2019;139(7):1480-1489.9Ratnarajah K, et al. Journal of Cutaneous Medicine and Surgery. 2021;25(3):315-328.10Bieber T. Allergy. 2020;75(1):54-62.

Logo - https://mma.prnewswire.com/media/1217694/Almirall_Logo.jpg

SOURCE Almirall, S.A.

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Almirall: Eight out of Ten Patients Maintained Skin Clearance at One Year in Lebrikizumab Atopic Dermatitis Monotherapy Trials - PR Newswire UK

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Poll: Six in 10 people would eat food that has fallen on the floor – Coventry Live

Posted: at 1:49 am

Tile Warehouse has surveyed the UK public to determine who abides by the five-second rule, and how its perceived differently across the country. This so-called rule says food is OK to eat if you pick it up in five seconds or less.

Results have revealed that the threat of contamination isnt stopping Brits from eating fallen food, with almost six in 10 (59%) agreeing that they would still eat food that had touched the floor. Of those who agreed, one in six (16%) preferred to only leave food for four to five seconds, following the favoured rule's steps.

Just over 1% claimed that they would eat food left on the floor for up to one minute. Even more shockingly, one in 20 people (5%) claimed that they would eat the food no matter how long it had been left on the floor.

The study found that women (56%) were less likely to eat food off the floor than men (61%). It seems that generational divides also extend to the five-second rule, with millennials (aged 24-42) the most likely to leave food on the floor the longest.

Members of this generation gave seven seconds as the average amount of time they would comfortably leave food on the floor before eating it. A closer look at the regions found that those in Scotland were likely to leave food on the floor for the longest amount of time with an average of 10 seconds.

In second place was Greater London, with residents admitting they would leave their food on the floor for a maximum of six seconds at a time. The research was conducted by Censuswide among 2,000 general consumers aged 18 and over in May 2022.

For more stories from where you live, visit InYourArea.

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How a persistent diver in the Bahamas solved a WW II mystery involving a Halifax pilot – CBC.ca

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Tom O'Neill didn't know what to think when he got an unexpected email last fall.

The email was from a man who claimed to have found aplane, the oneO'Neill'suncle was in when it crashed during the Second World War. The plane was located off the coast ofNassau, Bahamas.

O'Neill's uncle, Maurice (pronounced Morris) O'Neill was from Halifax. He was one of two people to die after a mechanical failureon a B-26 Marauder on Oct. 17, 1944, during a training exercise.

"It was interesting to hear what happened," said Tom O'Neill, who lives in Villa Nova, Ont. "They didn't talk a lot about it in the family, just that he'd gone down, [they] didn't know the circumstances or why they had not been able to find them."

The discovery of the plane also providedanswers to Joanne Green of Guelph, Ont. Her uncle, Jack Wood, was the other person on the plane.

"My mom didn't like to talk about it," said Green."She was always very upset. So when this started, this has gone from a little bit of family lore to, like, this is real."

The discovery was thanks to Eric Wiberg, a determinedAmerican who lives in Boston. He frequently visits the Bahamas and spent time there growing up.

Last year was a tragic one for him. A nephew who lives in the Bahamas died in a car accident and hismom died after an eight-year battle with cancer.

He found solace in diving and became fixated on finding something he spotted decades ago as a teen.

While out on a friend's powerboat In 1985, he and his best friend came across the wheel from a plane.

"I was mesmerized," he said."Basically, what the hell is a wheel doing on a reef, you know? It really caught my imagination and that question stuck with me."

Wiberg is an author and historian who has published more than a dozen books. One of those books isBahamas in World War II: A Military Chronology 1939-1945.

The Bahamas was an important training ground for pilots during the war, as well as a critical stopping point for aircraft constructed in North America making the journey overseas, saidJeff Noakes,a Second World War historian at the Canadian War Museum in Ottawa.

While it was possible to disassemble aircraft and transport themby ship, that came with problems.

"That takes time and it takes up room on ships that can be used for other things and if the ships get sunk, you lose the aircraft," he said.

As a result, the Bahamas was a popular transit point for Allied aircraft.

Wiberg's book, in part,looks at the more than 100 Royal Air Force crashes that happened on the Caribbean island during the war.

One of those crashes caused the deaths of O'Neill and Wood. The location listed on official military records led Wiberg to believe theplane wheel he spotted in 1985 was from that crash.

"I was just deathly afraid that somebody else would find it and desecrate it and steal," he said.

Engulfed in personal turmoil, he set out to find the plane.

He thought he found it, but his hopes were dashed when aviation experts rebuked him. They told him he'd found the remnants of a Beechcraft plane, not the B-26 Marauder flown by O'Neill and Wood.

It wasn't even the plane he had spotted in 1985.

"My colleagues in Australia and other places rejected me and said, 'You've wasted our time. This is obviously not a B-26. You obviously don't know what you're doing,'" said Wiberg.

He was dejected, but became more determined than ever to find the plane flown by O'Neill and Wood.

While the crash report offered up latitude and longitude, Wiberg's dive in the area turned up unsuccessful.

Eyewitnesses had been consistent that the plane crashed 400 yards (366 metres)from shore. Aided by a reference to where a building was located, Wiberg'sfocus narrowed.

"So if you ... drew a line and you swam that line, eventually you'd find something, right?" said Wiberg.

Over a span of three weeks last November and December, Wibergspent about five hours a day diving around a 1.6-kilometregrid. An accomplished swimmer in his youth, Wibergdove without a breathing apparatus.

Fittingly, he made his breakthrough on Remembrance Day, finding a first piece from the plane, about three kilometresfrom where the official records said the plane would be. In the weeks that followed, he found around 45 pieces belonging to O'Neill and Wood's B-26 Marauder.

"I had done my job," Wibergsaid, fighting back tears.

The diving, done in depths averaging six to seven metres, was physically demanding. The twisting and turning caused by trying to lift wreckage from the sea floorcaused acase of stenosis.

In some cases,Wibergfound the wreckage within three metres from the shore.

The area where he dove is located on the north coast of Nassau, which housesthe Marley Resort and Spa,formerly a vacation home for famed musician Bob Marley.

O'Neill then contacted Green. They had first met several years ago through the research he did for Bahamas in World War II: A Military Chronology 1939-1945. She helped Wiberg connect with Tom O'Neill.

Green is an only child and her mother's only sibling was Jack Wood. Her father did not have any siblings.

Interested in genealogy, she's long tried to find answers about her family's history.

Wiberg's discovery has brought her one step closer to the uncle she never met.

Woodmarried a year or so before he enlisted in the war in 1942 and worked as an assistant manager in the mail order department for Simpsons in Toronto. He had a son, John Jr., who was only 10 months old when Wood died.

"I think it's all about closure, you know, coming full circle," said Green."Someone I didn't know at all, and now I feel like I know him. He was a good guy and that's just great with me."

For Tom O'Neill, the discovery gives him a better understanding of his Uncle Maurice, who lived in south-end Halifax.

Before the war, O'Neillworked in a stationery shop in downtown Halifax with his father. Tom O'Neill believes his uncle planned to return to work there after the war.

Green said her mother was always bothered by the fact no funeral was held for Uncle Jack. She was told it wasn't allowed. The reason why is unclear.

But that will change.

Green plans to go to the Bahamas this fall to have a memorial service in the area where the plane crashed. Wiberg has even lined up a bugler for the occasion.

"Here we are, like, the next generation, us meeting up," said Green."And I hope that we maintain our friendships."

For Wiberg, finding the B-26 Marauder wasn't an action just fuelled by grief. It was an act of family history.

His father was a longtime Swedish consulin the Bahamas. He instilled in his childrenthe value of service to others, especially when they were far from home.

Locating the B-26 Marauder wasn't the rewardit was letting O'Neill and Green know what happened to their uncles.

"I brought them back to life in a small way," said Wiberg.

For Noakes, the Canadian War Museum historian, stories like that of O'Neill and Woodare important to remember.

"These are loved ones who never came home or someone who's always been a picture in a family photo album, so there's obviously that connection," he said.

"It bears tremendous importance for people who have these direct personal connections to these events. It's also important because it is a reminder that the Second World War has this global impact and takes Canadians to locations around the world that people here in Canada right now might not necessarily think of."

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Goals and Summary of Trinidad and Tobago 1-0 Bahamas in CONCACAF Nations League. – VAVEL.com

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9:54 PM4 hours ago90'

The match Trinidad and Tobago 1-0 Bahamas is over.

Last minutes of the match, Trinidad and Tobago is taking the 3 points at home.

A very clean game with only 3 yellow cards.

Time is running out and the locals are dominating the game at will.

Trinidad and Tobago missed many opportunities to increase its score.

Changes are made in the Bahamas' squad to make them more offensive.

Trinidad and Tobago in turn wants the goal that will increase its lead.

The Bahamas started the second half with the intention of going for the equalizer.

The second half begins.

End of the first half Trinidad and Tobago 1-0 Bahamas.

the last minutes of the first half, Trinidad and Tobago will go into the break with the lead.

The game remains level with a one-goal advantage for the home team.

Trinidad and Tobago has more shots on goal but fails to be effective.

Bahamas also insists and looks for the equalizer in a very close game.

The match drops a little in intensity as Trinidad and Tobago looks to increase its lead.

Little by little, the Bahamas took possession and tried to generate dangerous plays.

Trinidad and Tobago dominated the first few minutes after the goal.

Gooool for Trinidad and Tobago, the scoreboard opens quickly.

Trinidad and Tobago and Bahamas match kicks off

Everything is ready for the start of the match, the two teams are preparing to take the field.

The stadium has a great entrance for the match of the second day of the CONCACAF Nations League, a great game is coming.

The two teams are warming up and preparing for the start of the match.

Both teams are already at the stadium and are getting ready to warm up.

The fans are slowly arriving at the stadium for the start of this CONCACAF Nations League match.

Only Trinidad and Tobago will be without center forward Kevin Molino, one of their top scorers with 48 games played and 16 goals, due to injury, while the Bahamas will be able to count on a full squad for tomorrow's game.

In a few moments we will share with you the Trinidad and Tobago vs Bahamas live scores, as well as the latest information from Hasely Crawford Stadium. Stay tuned to VAVEL Mexico's live minute-by-minute coverage of the match.

4. Bateau, 2. Aubrey David, 11. Garcia, 14. Shannon Gomez, 18. Triston Hodge, 19. Keston Julien, 6. Moses, 23. Paul, 1. Marvin Phillip, 5. Phillips, 15. Rochford. DT: Angus Eve.This is the latest lineup for Trinidad and Tobago.

After defeating St. Vincent and the Grenadines 1-0, the Bahamas will be looking for one more win, but they will not have an easy task, as they will have to visit Trinidad and Tobago in a match that is sure to spark many sparks in the CONCACAF Nations League.

After losing their first match against Honduras 2-1, Trinidad and Tobago will be looking to get out of their slump against the Bahamas in a match that will be vital for their aspirations in the tournament, as they will then have to visit St. Vincent and the Grenadines in another match of great importance for the Central Americans.

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WHAT’S NEW IN THE BAHAMAS IN JUNE – PR Newswire

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NEWSLong Island Regatta Sets Sail Salt Pond Harbour welcomes sloop sailors and spectators to the Long Island Regattafrom 1 to 4 June 2022. Participants will compete for cash prizes and bragging rights while visitors shop artisan vendors and enjoy authentic food and drinks.

Competition Heats Up on Grand Bahama Island Join members of the Battle Ground Bahamas Yellowfin Tuna Fishing Tournamentfor a second year, from 2 to 4 June 2022, for championship fishing on Grand Bahama Island.

The Annual Pineapple Fest Returns to Eleuthera The sweet taste of summer and homegrown flavours return to Gregory Town, Eleuthera for the annual Pineapple Festfrom 3 to 4 June 2022. In honour of the island's agricultural heritage, festivities include musical entertainment, interactive games, and culinary competitions.

Cat Island Rake 'N Scrape Festival Celebrates Local Music Residents and visitors are invited to the annual Cat Island Rake 'N Scrape Festivalfrom 2 to 4 June 2022. Enjoy live performances by local and national artists, "down home" cuisine, and authentic craft goods.

The Ocean Club, A Four Seasons Resort Marks its 60th Anniversary In celebration of 60 years in The Bahamas, The Ocean Club, A Four Seasons Resort,ushers in a new era of glamour with ultra-exclusive culinary experiences and programming.

PROMOTIONS AND OFFERSFor a complete list of promotions, deals and packages available now for a vacation in The Bahamas, visitwww.bahamas.com/deals-packages.

Atlantis Paradise Island Launches Summer Sale Guests who book four or more consecutive nights at either The Royal or The Coral at Atlantis Paradise Island Bahamasbefore 8 June 2022 earn the fourth night free. The travel window is now through 31 October 2022.

Family Fun Awaits at Margaritaville Beach Resort Nassau This summer, book a five-night stay at Margaritaville Beach Resort Nassau with the "Fam"tastic Stay & Playoffer to receive a $350 food and beverage credit and unlimited access to the Fins Up Water Park and Parakeets Summer Camp. Travel window is now through 19 November 2022.

Caerula Mar Club and EvoJets debut the Ultimate Wedding Package Caerula Mar Club, a luxury resort on Andros, partners with private jet charter company EvoJetsto offer the Beachfront Bliss in The Bahamaswedding package. Included is VIP roundtrip transportation, three-night accommodations for the couple and bridal party, and ceremony essentials like the wedding cake and bridal bouquet. The booking window is now through 31 December 2022.

ABOUT THE BAHAMASSee why It's Better in The Bahamas at http://www.bahamas.com or on Facebook, YouTube or Instagram.

PRESS INQUIRIESAnita Johnson-PattyBahamas Ministry of Tourism, Investments & Aviation[emailprotected]

Weber ShandwickPublic Relations[emailprotected]

SOURCE The Bahamas Ministry of Tourism, Investments & Aviation

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OSU to Reportedly Take Part in Thanksgiving Hoops Tourney in Bahamas – Pistols Firing

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If you happen to find yourself at a luxury resort in the Bahamas this Thanksgiving (as one does), you can also take in some OSU hoops.

According to a report by college hoops insider Jon Rothstein, Oklahoma State will take part in a multi-team event this coming Thanksgiving weekend at the Baha Mar resort in the Bahaman Islands. Joining the Cowboys in the event are DePaul, UCF and Santa Clara.

Oklahoma State is 7-3 all-time against DePaul with the last matchup ending in a 60-56 OSU win in 2010, but theres a more current Cowboy connection. Former OSU big man Yor Anei played for the Blue Demons last season and is on the current roster.

Oklahoma State and UCF have yet to meet and the Pokes history against Santa Clara is neither lengthy or current. OSU defeated Santa Clara 67-56 in the two schools only meeting back in 1953.

This just adds to an enticing noncon slate for the Pokes. OSU will also take part in the Hall of Fame Invitational in Brooklyn in December, according to a different report, and will face UConn in the Big East-Big 12 Battle. It will also take on Oakland on Nov. 13.

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Caribbean Flying Adventures Urges AOPA to Keep an Eye on the Bahamas Ball – AVweb

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The Customs Landing Requirement is only delayed. What is needed now are specific, workable recommendations and regular follow-ups by all parties.

1. Create a separate App for Private Pilots Click2Clear was designed for agents of import/export and has too many moving parts.

2. Use Fill-able C7A and ICAO General Declaration forms; pilots are already familiar with these paper documents. Customs can easily extract all the details they need from the online forms.

3. Drop passport data requirement. These are already collected by Immigration

4. Use an easy online payment app for $50 inbound processing fee and $29 departure taxes

5. Drop the threatening $5,000 fine for non-compliance

6. Retain the option of manual submission upon arrival for the few pilots who are not able to use online app; This costs nothing and saves tourism revenues that would otherwise be lost.

May 18: Everyone is blindsided by the unannounced mandate of the onerous Bahamas Customs Click2Clear landing requirement except for the AOPA Bahamas representative who noted he was aware of the intention and had been reaching out to the Bahamas government. He is stonewalled like so many others.

May 21: Bahamas Ministry of Tourism arranges a meeting with Bahamas Customs and the Bahamas Aviation Ambassadors. The outcome was not good. A meaningless nine-day delay and no firm commitment to change anything except perhaps the requirement to upload passport images.

May 22: Caribbean Flying Adventures (CFA) writes to Mark Baker encouraging his direct intervention and also contacts major Bahamas newspapers and key FBO managers around the Bahamas. AOPA receives a ton of emails and calls from Caribbean Flying Adventures member pilots urging action.

MAY 24: Mark Baker responds to CFA with a copy of the AOPA letter to the Bahamas government saying he only recently learned from third partiesof the May 30 implementation. By now, the Bahamas press and the local aviation sector are all over the story and have involved numerous members of parliament to actively challenge the Customs initiative. The AOPA letter was a welcome component of a pressure campaign from all sides.

May 31: Bahamas customs notifies Bahamas Tourism of the decision to indefinitely suspend the application. Bahamas Customs did not copy AOPA nor any of the Bahamas FBOs. Thanks to Bahamas Tourisms Greg Rolle for sharing the good news.

June 1: AOPA issues a press release stating that Mark Baker learned of the problem from his AOPA Bahamas rep, which for whatever reason, is not consistent with his letter to the Bahamas on May 24 that it has come to my attention from third parties. An AOPA spokesman told the Bahamas Tribune Business newspaper that the organization had received many inquiries from private pilots voicing concern about The Bahamas new Click2Clear clearance system. I am not sure of the exact number, but what I can confidently say is that theres been many inquiries.

June 1: CFA sends letter to Mark Baker urging AOPA to present to the Bahamas specific suggestions to simplify the application. On May 22, CFA had also provided AOPA with a detailed recommendation that would radically simplify the process. The CFA recommendations have been picked up by the Bahamas Press but need immediate backing from AOPA and others. Together, we need to insure that Click2Clear, if and when it is reintroduced, provides the Bahamas with the same information it currently receives from paper documents without dragging private pilots through an a tortuous hour of online gymnastics.

For details go to: http://www.CaribbeanFlyingAdventures.com or contact Jim Parker 305-667-6282 or Jim@CaribbeanFlyingAdventures.com.

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