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Daily Archives: May 6, 2022
Opus Genetics Announces Promising New Data Highlighting Potential of AAV-based Gene Therapies for the Treatment of Rare Inherited Retinal Diseases -…
Posted: May 6, 2022 at 12:44 am
Retinal regions of preserved photoreceptors identified as targets for subretinal delivery of AAV8-based gene therapy to address mutations in genes that cause forms of Leber congenital amaurosis
Subretinal injection well tolerated in preclinical dose-ranging studies
Data presented at Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022
RESEARCH TRIANGLE PARK, N.C., May 04, 2022 (GLOBE NEWSWIRE) -- Opus Genetics, a patient-focused gene therapy company developing treatments for inherited retinal diseases, today announced promising new preclinical data from studies evaluating the potential of its gene therapies OPGx-001 and OPGx-002 to address forms of Leber congenital amaurosis (LCA), a group of rare inherited retinal diseases characterized by photoreceptor degeneration, due to mutations ofLCA5orRDH12genes, respectively.
In preparation for IND-enabling trials of OPGx-001 and OPGx-002, studies were conducted to determine eligibility, therapeutic window, and possible outcome measures for gene therapy for LCA5 and RDH12 inherited retinal diseases. In addition, safety evaluations for the subretinal delivery of an AAV8 vector containing LCA5 or RDH12 were performed in non-human primates (NHP).
The data demonstrated that despite severe retinal dysfunction, LCA patients exhibited detectable photoreceptor regions that may be targets for gene augmentation, identified in the central and midperipheral retina of LCA5-LCA patients and in the pericentral and peripapillary retina of RDH12-LCA patients. In two dose-ranging studies in NHPs, subretinal delivery of OPGx-001 and OPGx-002 was well tolerated, with mild inflammatory changes observed at the higher dose. The data support the therapeutic potential and tolerability of gene augmentation to address LCA5-LCA and RDH12-LCA and provide guidance for formal preclinical toxicology studies and future human clinical trials.
Patients with Leber congenital amaurosis due to mutations of the LCA5 or RDH12 genes experience rapid retinal degeneration, resulting in vision loss in early childhood, said Ash Jayagopal, Ph.D., Chief Scientific Officer of Opus. The detection of preserved photoreceptors in LCA patients signals a therapeutic opportunity to target the mutation and potentially restore structure and function through gene augmentation. In addition, the encouraging dose-ranging results in the primate model suggest subretinal delivery of Opus AAV8-based gene therapies are safe and inform the doses to be used in our toxicology studies, a key step on our path toward the clinic for OPGx-001 and OPGx-002.
The data were presented today at the Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting 2022 in Denver, Colo., by Jean Bennett, M.D., Ph.D., Scientific Co-founder, Opus Genetics, and University of Pennsylvania Perelman School of Medicine; and Tomas Aleman, M.D., University of Pennsylvania Perelman School of Medicine.
Also at ARVO 2022, Dr. Jayagopal was awarded the title of ARVO Fellow, an honor established to recognize current ARVO members for their individual accomplishments, leadership and contributions to the ARVO Association.
About Opus GeneticsOpus Genetics is a groundbreaking gene therapy company for inherited retinal diseases with a unique model and purpose. Backed by Foundation Fighting Blindnesss venture arm, the RD Fund, Opus combines unparalleled insight and commitment to patient need with wholly owned programs in numerous retinal diseases. Its AAV-based gene therapy portfolio tackles some of the most neglected forms of inherited blindness while creating novel manufacturing scale and efficiencies. Based in Research Triangle Park, N.C., the company leverages knowledge of the best science and the expertise of pioneers in ocular gene therapy to transparently drive transformative treatments to patients. For more information, visit http://www.opusgenetics.com.
Media Contact: Heather Anderson6 Degrees919-827-5539handerson@6degreespr.com
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A very specific kind of brain cell dies off in people with Parkinson’s – Science News Magazine
Posted: at 12:44 am
Deep in the human brain, a very specific kind of cell dies during Parkinsons disease.
For the first time, researchers have sorted large numbers of human brain cells in the substantia nigra into 10 distinct types. Just one is especially vulnerable in Parkinsons disease, the team reports May 5 in Nature Neuroscience. The result could lead to a clearer view of how Parkinsons takes hold, and perhaps even ways to stop it.
The new research goes right to the core of the matter, says neuroscientist Raj Awatramani of Northwestern University Feinberg School of Medicine in Chicago. Pinpointing the brain cells that seem to be especially susceptible to the devastating disease is the strength of this paper, says Awatramani, who was not involved in the study.
Parkinsons disease steals peoples ability to move smoothly, leaving balance problems, tremors and rigidity. In the United States, nearly 1 million people are estimated to have Parkinsons. Scientists have known for decades that these symptoms come with the death of nerve cells in the substantia nigra. Neurons there churn out dopamine, a chemical signal involved in movement, among other jobs (SN: 9/7/17).
But those dopamine-making neurons are not all equally vulnerable in Parkinsons, it turns out.
This seemed like an opportunity to really clarify which kinds of cells are actually dying in Parkinsons disease, says Evan Macosko, a psychiatrist and neuroscientist at Massachusetts General Hospital in Boston and the Broad Institute of MIT and Harvard.
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The tricky part was that dopamine-making neurons in the substantia nigra are rare. In samples of postmortem brains, we couldnt survey enough of [the cells] to really get an answer, Macosko says. But Abdulraouf Abdulraouf, a researcher in Macoskos laboratory, led experiments that sorted these cells, figuring out a way to selectively pull the cells nuclei out from the rest of the cells present in the substantia nigra. That enrichment ultimately led to an abundance of nuclei to analyze.
By studying over 15,000 nuclei from the brains of eight formerly healthy people, the researchers further sorted dopamine-making cells in the substantia nigra into 10 distinct groups. Each of these cell groups was defined by a specific brain location and certain combinations of genes that were active.
When the researchers looked at substantia nigra neurons in the brains of people who died with either Parkinsons disease or the related Lewy body dementia, the team noticed something curious: One of these 10 cell types was drastically diminished.
These missing neurons were identified by their location in the lower part of the substantia nigra and an active AGTR1 gene, lab member Tushar Kamath and colleagues found. That gene was thought to serve simply as a good way to identify these cells, Macosko says; researchers dont know whether the gene has a role in these dopamine-making cells fate in people.
The new finding points to ways to perhaps counter the debilitating diseases. Scientists have been keen to replace the missing dopamine-making neurons in the brains of people with Parkinsons. The new study shows what those cells would need to look like, Awatramani says. If a particular subtype is more vulnerable in Parkinsons disease, maybe thats the one we should be trying to replace, he says.
In fact, Macosko says that stem cell scientists have already been in contact, eager to make these specific cells. We hope this is a guidepost, Macosko says.
The new study involved only a small number of human brains. Going forward, Macosko and his colleagues hope to study more brains, and more parts of those brains. We were able to get some pretty interesting insights with a relatively small number of people, he says. When we get to larger numbers of people with other kinds of diseases, I think were going to learn a lot.
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A very specific kind of brain cell dies off in people with Parkinson's - Science News Magazine
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Gene Editing Tools Market by 2029 Thermofisher Scientific, CRISPR Therapeutics, Editas Medicine Queen Anne and Mangolia News – Queen Anne and…
Posted: at 12:44 am
Gene Editing Tools Marketresearch is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis. It also provides market information in terms of development and its capacities.
Gene Editing Tools Market is growing at a High CAGR during the forecast period 2022-2029. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.
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Thermofisher Scientific, CRISPR Therapeutics, Editas Medicine, NHGRI, Intellia Therapeutics, Merck KGaA
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Gene Editing Tools Market by 2029 Thermofisher Scientific, CRISPR Therapeutics, Editas Medicine Queen Anne and Mangolia News - Queen Anne and...
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Sleep deprivation may increase the risk of eye disease – Medical News Today
Posted: at 12:44 am
While scientists know that sleep deprivation has a negative effect on the body, they are still researching how it affects different organs.
Researchers from China and the U.S. recently published a study in Stem Cell Reports on how poor sleep can affect the eyes. They found that sleep deprivation can affect both stem cells in the cornea and the tear film surface of the cornea.
Getting a good nights sleep on a regular basis is important, but according to the Centers for Disease Control and Prevention (CDC), more than one-third of adults dont get enough sleep. Doctors recommend that adults get at least 7 hours of sleep per night.
The CDC reports that not getting enough sleep can cause a myriad of health issues, such as having a higher risk for obesity, developing diabetes, and high blood pressure.
Part of the issue contributing to so many people not getting enough rest is having a sleep disorder. The National Institutes of Health reports that around 40 million Americans have a sleep disorder.
Some sleep disorders include:
For those who are not affected by a sleep disorder, the best way to regularly get enough sleep is to practice good sleep hygiene. People can accomplish this by going to bed at the same time every night, avoiding screens 1-2 hours before bed, and not drinking alcohol before bed.
The researchers in this study used mice to learn more about how sleep deprivation affects the eyes.
According to the authors, the cornea is the clear front surface of the eye. They also write that the cornea has an overlying tear film that helps keep the eyes comfortable and offers protection against infection.
The researchers were interested to find out to what degree sleep deprivation may affect stem cells in the cornea.
As Dr. Neil Neimark, a board certified family physician in functional medicine who applies stem cell therapy in his practice, noted in a TEDx Talks podcast, stem cells have healing power and all tissue repair in the body is initiated by stem cells.
The researchers of the current study assessed gene expression in the mice after 2 days of sleep deprivation and then after 10 days of sleep deprivation.
At the 2-day point, the researchers found that 287 genes were significantly upregulated and 88 were downregulated in corneas. At the 10-day point, they saw 272 significantly upregulated genes and 150 downregulated genes.
The authors tested the mice after 1 and 2 months of further sleep deprivation and found that the transparency of the cornea was reduced and the ocular surface was rough.
While stem cells were upregulated in the sleep-deprived mice early on, it eventually led to what the authors referred to as an early manifestation of limbal stem cell deficiency. After being upregulated for so long, the stem cells became depleted.
Short-term consequences of insufficient sleep or delayed sleep cause ocular discomfort, including dryness, pain, pruritus, and hyperemia of the eye, the authors note.
Despite these issues, the authors observed that treating the mice with damaged corneas with eye drops containing antioxidants helped restore the eye health of the mice.
Dr. Howard R. Krauss, a surgical neuro-ophthalmologist and director of Neuro-Ophthalmology for the Pacific Neuroscience Institute at Providence Saint Johns Health Center in Santa Monica, CA, who was not involved in the study, spoke to Medical News Today about the findings.
The design of the study was to study chemical and cellular changes in the ocular surface of sleep-deprived mice, revealing indeed that there are damaging effects, which shed light on mechanisms which may be at play in human symptoms and disease, Dr. Krauss said.
While Dr. Krauss thought the study was helpful at showing how sleep deprivation can potentially affect humans, he noted a limitation.
A weakness of the study is the methodology by which sleep deprivation is induced in mice, who are in cages, perched on sticks to remain above a water-filled bottom when the mouse falls asleep, it falls into the water, immediately wakes up, and climbs back up onto the stick, Dr. Krauss explained.
Dr. Krauss said the method used to induce sleep deprivation raises the question of how much of the chemical and cellular change they observed was purely secondary to sleep deprivation and how much may be a stress reaction to the means by which sleep deprivation has been engineered.
Nonetheless, the study refocuses our attention on sleep deprivation and leads us to think that the scope of damaging effects of sleep deprivation may be far [broader] than we realize, he said.
As such, the human need for sleep for maintenance of good health becomes more obvious every day. Dr. Howard R. Krauss
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UK still wants deal with EU on Northern Ireland Brexit rules, minister says – POLITICO Europe
Posted: at 12:43 am
LONDON Britain still wants to resolve a row with Brussels over post-Brexit trade rules for Northern Ireland, a senior minister said, as he was pressed on reports the U.K. is preparing to unilaterally rip up parts of the arrangement.
In an interview with ITV News, the U.K.s Northern Ireland Secretary Brandon Lewis declined to confirm multiple reports that legislation paving the way for Britain to ignore parts of the controversial Northern Ireland protocol is being readied for next weeks queens speech. That speech marks the opening of a new parliamentary session and sets out the U.K. governments agenda.
Asked if Britain is preparing to announce a plan along those lines, Lewis said: Our focus is on resolving the issues with the protocol, ideally we want to do that by agreement with the European Union.
Pressed further on whether an announcement would come next week, he said: No weve not said that."
And he added: "What weve been clear about is at the moment, the protocol is causing problems in civic society, its causing problems with the Good Friday Agreement. Our duty to the people of Northern Ireland is to resolve those issues. Yes, we want to do that with the EU and thats what [Foreign Secretary] Liz Truss has been focused on.
U.K. ministers have previously acknowledged that the government is considering a range of options in case the talks with the European Commission on the protocol which was drawn up to avoid a hard border between Ireland and Northern Ireland post Brexit but is deeply unpopular with Northern Irelands unionists do not yield solutions. But they have stopped short of publicly setting out their thinking.
Truss reiterated to her Irish counterpart Simon Coveney Wednesday evening that the protocol is not working, while the Irish minister told her during the same phone call that unilateral action [is] not the way forward.
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Embarrassed to be British: Brexit study reveals impact on UK citizens in EU – The Guardian
Posted: at 12:43 am
The first major study since Brexit of UK citizens living in the EU has revealed its profound impact on their lives, with many expressing serious concerns over their loss of free movement and voting rights and a very different perception of Britain.
The survey, of 1,328 British nationals across the continent, showed that if the public narrative suggests Brexit is done and dusted, it has brought deep transformations to the lives of British citizens in the EU and EEA, the studys co-lead, Michaela Benson, said.
The long tail of Brexit is evident in its continuing impacts both on the way they live their lives, and in its lasting significance for their sense of identity and belonging, said Benson, a sociology professor at Lancaster University.
The survey, conducted between December 2021 and January 2022, a year after the end of the Brexit transition period, and part of a wider project by Lancaster and Birmingham universities, found 59% of respondents had lived in their country of residence for at least five years and most intended to stay.
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But many were angered by their loss of free movement, meaning they can no longer move within the EU for work, or retire to another EU country, and especially worried about being unable to return to the UK with non-British family members in future.
Asked whether their past or future migration plans had been affected by Brexit, 27% of respondents said it had affected them a great deal, and 14% a lot. Where does one even start? was the response of one British citizen living in Belgium. Loss of rights like freedom of movement around the EU and to the UK. With a wife who is an EU citizen, I had to decide whether to move to the relevant EU country or stay in the UK. Family now cannot move back to Britain. Uncertainty.
Another said: I moved to France in 2020 in order to protect my right to live and work in France post-Brexit. My migration is 100% a result of Brexit.
Brexit, and the British governments handling of the Covid pandemic, strongly affected 80% of respondents feelings towards the UK, with responses including deep shame, disappointment, a shit show, embarrassed to be British, shambolic, and like watching a house on fire.
Just over 30% still felt very or extremely emotionally attached to the UK, compared with 75% who said they felt a very or extreme emotional attachment to the EU, and 59% who felt the same in relation to their country of residence.
For me, one of the most interesting things the survey reveals is this sense of disappointment, shame and anguish over Brexit and the pandemic and a really quite pronounced expression of European identity, Benson said.
About two-thirds had changed their legal status since 2016, acquiring residency or citizenship. But nearly half did not have the same status and therefore the same migration and settlement rights as some or all of their close family members.
This was a major or significant concern for a large majority of respondents, who said it was affecting their own and their childrens work, career and education, or would do so in the future.
My wife is a Russian citizen, said one respondent in Italy. Her right to live and work depend upon my status under the withdrawal agreement. She fears a potential move to another EU country as her residency rights are totally dependent upon mine.
Those who felt they may want or need to move back to the UK at some stage felt particularly affected, since non-British partners and other family members coming with them would now be subject to UK domestic immigration controls.
I have a house in England, said one respondent, who has lived in the Netherlands for 10 years. I was going to retire there. Its now being sold. My wife is Dutch. I do not think she could even relocate back to the UK despite joint ownership of a house, having lived there for 15 years, being fluent in English and having two dual-nationality kids.
The loss of EU voting rights was also a big concern, with 46% saying they could no longer vote in European elections or, in most cases, local elections in their country of residence. Roughly 42% were also unable to vote in the UK because they had lived abroad for more than 15 years, although this is expected to change.
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Have we just travelled back in time? Because Nigel Farage has just called for Brexit, again – indy100
Posted: at 12:43 am
Take a look at the calendar. Yep, you got it right, it is really 2022. The Brexit referendum was six years ago, and Britain has been officially sans Europe for a couple of years.
So why on earth is Nigel Farage calling for Brexit, again?
Yes, Farage has really called for a policy that has already happened. Posting a story about lawyers opposing the government's controversial Rwanda plan, he blamed Johnson for keeping the UK in the European Court of Human Rights (ECHR), which isn't what the story is about, and said: "Time for a proper Brexit".
Reminder: Britain left the EU on 31st January 2020, after years of tense negotiations and debates about whether to have a second referendum.
To make matters even more awkward for our Brexit loving friend, the ECHR isn't actually in the EU. It is part of the Council of Europe, which was founded after WWII to uphold human rights. The court serves that mission from a legal perspective.
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People provided a helpful fact-checking service to Nige:
His intervention comes as Johnson faces questions about the Rwanda plan, which seeks to displace immigrants deemed illegal by the UK to the African country for processing, asylum and resettlement. Speaking to reporters on Wednesday about it, the Prime Minister said: Its a great deal between two countries, each helping the other.
Of course, there are going to be legal eagles, liberal lawyers, who will try to make this difficult to settle. We always knew this was going to happen, but it is a very, very sensible thing.
If people are coming across the Channel illegally, and if they are, their lives are being put at risk by ruthless and unscrupulous gangsters, which is what is happening at the moment.
He added: You need a solution. And you need something that is going to say to those people, to those gangsters, Im sorry, but you cant tell your customers, you cant tell these poor people, that theyre just going to come to the UK, and theyre going to be lost in the system, because were going to find a way of making sure that they are going immediately to Rwanda.
I think thats a humane, compassionate and sensible thing to do. Im not going to pretend to you that is going to be without legal challenges. I think I said that when I announced it, but we will get it done.
Say what you like about Farage though, making everything about Brexit is a truly remarkable skill. But it is time for him to find something new to bang on about, we reckon.
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Stephen Booth: Brexit’s legacy, the Northern Ireland Protocol, small boats and Britain’s tense relationship with Macron – ConservativeHome
Posted: at 12:43 am
Stephen Booth is Head of the Britain in the World Project at Policy Exchange.
To the relief of the French and European establishment, Emmanuel Macrons re-election makes him the first two-term French President in 20 years since Jacques Chirac. However, the 17-point margin of his victory over Marine Le Pen does not tell the whole story. Voter turnout was the lowest in a presidential run-off since 1969 and Le Pen increased her vote tally from 10.6 million in the second round in 2017 to 13.2 million this time around.
It is probable that Macron will secure a working majority in the National Assembly elections in June. But with such a high percentage of disaffected voters on the left and the right, and both camps opposed to giving Macron a mandate to pursue his economic reforms, surprises cannot be ruled out.
Five years is a long time in politics. However, the nature of Macrons victory and the trend towards polarisation of the French political system does beg the question of what his domestic legacy will be. Having decimated the traditional centre-left and centre-right parties, which has allowed the fringes on the left and right to flourish, can the centre produce a successor to Macron in 2027?
Nevertheless, in the immediate term, Macron will feel that his victory puts him in the ascendency on the European stage and he will continue have a strong influence over the direction of the EU, including on relations with the UK. Hopes of a swift reset of Anglo-French relations following Macrons re-election look unlikely to materialise. Frances Finance Minister, Bruno Le Maire, made a point of telling reporters after Macrons victory that our first challenge will not be the relationship between the UK and France.
Macron is likely to double down on his vision for EU integration and strategic autonomy. He has some like-minded allies for this agenda, such as Italys Prime Minister, Mario Draghi, who this week called for pragmatic federalism in the fields of economy, energy, and security and defence.
However, in security and foreign policy, Macron could struggle to assert French leadership within the EU as he would like. The crisis in Ukraine has strengthened the position of key UK allies, particularly among the Nordics, Baltics, and several Eastern countries, that EU policy must not undermine or be in competition with NATO. Macrons previous efforts to open a seemingly unilateral dialogue with Vladimir Putin and his ambivalence towards US leadership of NATO continue to make them suspicious of French strategic direction in this area.
The Prime Ministers leadership on Ukraine has built up goodwill towards the UK in many of these countries, and the UK should continue to work with these nations on making the case that European security cooperation should enhance rather than detract from NATO. The UKs response to Ukraine illustrates that Global Britain does not come at the expense of a commitment to European security and prosperity in the most fundamental sense.
Clearly, there remain difficult issues between the UK and France where Macron appears reluctant to help. For example, notwithstanding the Governments new policies to tackle people smuggling and illegal cross-Channel migrant crossings on small boats, the problem would be much more easily addressed through French cooperation to stop the perilous crossings at source on the French coast. However, politically, this remains a bigger problem for the Government than for Macron.
Meanwhile, France remains strongly opposed to a softening of the EUs stance in the talks on the Northern Ireland Protocol. The Queens Speech on 10 May is expected to include plans for a bill giving the Government new powers to replace parts of the Northern Ireland Protocol unilaterally, in an effort to break the impasse.
The UK should brace itself for a political reaction from Brussels, but it should continue to underline its overriding responsibility to uphold the Belfast/Good Friday Agreement. It should emphasise to its allies, in the EU and outside it, that a new political bargain that commands the consent of both communities in Northern Ireland is in the wider European interest and trumps the narrow focus on the EUs technocratic regulatory order.
With growing fears over unfair Chinese competition and supply chain resilience resulting from the experience of the pandemic, Frances calls for a more interventionist and strategic EU industrial policy may find an increasingly receptive audience. This could have implications for economic competition and cooperation between the UK and the EU, particularly in strategic technological and energy sectors.
The UK should work with Germany to ensure that a renewed EU focus on resilience does not spiral into a form of protectionism that strains UK-EU economic relations further. Germanys Chancellor, Olaf Scholz, is still bedding into the leadership role vacated by Angela Merkel. His three-way coalition is in the process of dramatically changing the course of German foreign and energy policy in response to the war in Ukraine, and Berlins recent commitment to buy US F-35 jet aircraft illustrates that Germany will not necessarily instinctively buy European, as Macron would wish.
Meanwhile, despite the recent Anglo-French flashpoints, which also included the row over the AUKUS alliance, more amiable bilateral relations in several areas should be mutually advantageous. The UK should continue to emphasise that both countries remain important security partners within the NATO framework. Germanys newfound appetite for defence spending may offer Macron another option on paper, but German strategic culture and its readiness to act is likely take far longer to change significantly.
Equally, the UK, unlike Germany, shares French enthusiasm for nuclear power as a means of bolstering domestic energy production. The UK would benefit from French industrial expertise and the UK offers a willing commercial partner.
Much has been made of the poor state of the Anglo-French relationship since Brexit. Personality clashes between Macron and Boris Johnson may well have something to do with it. However, the root remains the geopolitical fallout from Brexit, as viewed in London and in Paris, which are to be found in the concepts of Global Britain and EU strategic autonomy. Both countries therefore look set to continue to rub along uneasily, mixing elements of cooperation and competition along the way, but the UK has tools at its disposal to offer a constructive Anglo-French and UK-EU relationship.
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Brexit opportunities: Eight of your burning questions answered – The Independent
Posted: at 12:43 am
From the Northern Ireland protocol to potential opportunities, questions about Brexit and what it means continue to arise nearly five years after the UK voted to leave the European Union.
The Independents Adam Forrest, who authors the Brexit and Beyond newsletter, answered questions from readers about all things Brexit during an Ask Me Anything event.
Heres a selection of some the questions and answers.
The protocol in Northern Ireland is working to the benefit of exporters. Why try and amend it?
Theres certainly evidence of a huge jump in trade between Northern Ireland and the Republic of Ireland. In February, NI exports to the Republic were up 65 per cent compared with 2020, while exports from the Republic into NI were up 54 per cent. Trouble is, unionists take this as evidence of the six counties moving away from Great Britains orbit. While we cant be sure of the impact of Brexit on trade from GB into NI, theres little doubt Brexit has hit UK trade as a whole. Trade with the rest of the world is down by 12 to 13 per cent below their 2019 averages, according to the most recent estimate by the Office for Budget Responsibility.
How is the EU going to respond to this Article 16 nonsense? Surely theyre going to get fed up of Boris antics and do without a trade deal with us.
Rather than triggering Article 16, the UK bill looks set to put the ball in the EUs court. Brussels has already made clear it is prepared for retaliatory measures if the UK tears up its protocol obligations. It could take the nuclear option of terminating the Trade and Cooperation Pact (TCA), or use Article 506 to begin imposing new tariffs on British goods. But the protocol-busting bill may not necessarily spark a trade war immediately. Worth bearing in mind that weve seen big crises aimed at triggering change, only for things to fall into the muddle of suspended legal action and further talks.
How can the government come up with a bill which breaks the law they already signed up to?
Ministers are said to be preparing a new bill that would give it new powers amount to switch off parts of the protocol that relate to border checks on good moving between GB and NI. There is speculation the legislation may try to repeal Section 7a of the EU Withdrawal Act the law which enshrines the protocol into UK law. EU diplomats have talked about the idea being utterly irresponsible with Brussels insisting that protocol is a legal obligation. One minister said the mother of all rows lies ahead.
How far will the British government go to appease anti-democratic unionism and ignore the will of the majority?
The timing suggests the protocol-busting bill being drawn up expectats that Sinn Fein will win the 5 May Northern Ireland elections. The unionist parties could potentially withdraw from both the executive and the assembly. The Queens Speech comes five days later on 10 May. So the government is likely to try to pounce on the sense of crisis and all the hysterical rhetoric from the DUP in a bid to shock the EU and much closer to the UK position. But the consequences are uncertain. Brussels patient cannot always be taken for granted.
Every time our PM is in trouble, he lashes out to the EU. Frankly it is getting predictable, boring even, this continued chaos But now? With the situation in Ukraine as it is?
It does seem convenient timing for Boris Johnson and his allies, who have tried to use the Ukraine crisis to deflect from Partygate. They may be desperate enough to dismiss the risks involved in this Brexit gambit. Former No 10 adviser Raoul Ruparel says talks on dropping GB-NI trade barriers have actually been moving slowly in the UKs direction so a big dispute would be massively counter productive. Its also damaging the chances of a US trade deal. And potentially hurts the UKs reputation with other prospective trade-dealing countries. As one EU diplomat has said: Why would you then sign anything with the UK ever?
Is the government really going to delay physical inspection checks coming in July again? Surely the uncertainty cannot be good for businesses.
The government has now scrapped the inspections on food imports from the EU that were set to come in on 1 July. Jacob Rees-Mogg has announced that they would not be enforced during 2022. Delayed until next year? Hard to say. Rees-Mogg suggested he wants complete overhaul of its border check plans revealing that end of 2023 was the target for a brand new controls regime. Despite remaining uncertainty about exactly what kind checks will come in next year, the Federation of Small Businesses and other industry groups have welcomed the move.
What are the benefits and opportunities Jacob Rees-Mogg is going on about it? I thought Brexiters might happy getting blue passports, but seems like this hunt for red tape to axe stuff is going to go on and on for years.
Jacob Rees-Moggs day job doesnt seem to be keeping him too busy. Hes had time to leave passive-aggressive notes on the desks of civil servants working from home. Grilled about the advantages of Brexit, Rees-Mogg was forced to talk about obscure things like gene-editing rules. Or retreat into silly abstractions like democracy. He has promised his Brexit freedoms bill would offer a mechanism for diverging from retained EU law in a way that will be much smoother and faster. But that stuff is a little dull. He seems unlikely to find any big, juicy wins that will keep Brexiteers as happy like getting blue passports.
My question on Brexit is: when will it end? When will the government admit that it is damaging the economy? When will the Labour Party open the door to closer ties with Europe, even joining the single market & customs union?
Keir Starmer remains reluctant to talk about it sticking to his vague commitment that a Labour government would be focused on making Brexit work by helping businesses (but ruled out re-joining single market and customs union). The Lib Dems have been reluctant too, chastened by their last election performance. But the partys spring conference recently backed a policy to seek to join the single market. So perhaps were seeing the start of something interesting.
These questions and answers were part of an Ask Me Anything hosted by Adam Forrest at 3pm on Thursday 28 April. Some of the questions and answers have been edited for this article. You can read the full discussion in the comments section of the original article.
Do you have any topics youd like to see an expert host an Ask Me Anything on? Let us know your suggestions in the comments below.
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Brexit opportunities: Eight of your burning questions answered - The Independent
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Brexit POLL: Has EU exit helped in fight against Putin and to support Ukraine? – Express
Posted: at 12:43 am
Britain has played a leading role in the Wests fight against Russian aggression, sending weapons, taking a hard line on Russian oil and gas, and cutting import tariffs for Ukrainian goods. Brexit has allowed the UK to act faster to target Russia, according to Bate Toms, chairman of the British-Ukrainian Chambers of Commerce.
He claimed the UK had been able to easily respond to the crisis thanks to the countrys position outside the EU.
He told Politico last month: Britain is now again in its historic role protecting Europe from conquest, freed from having to get along within the EU.
Historically, the Duke of Marlborough, the Duke of Wellington and Winston Churchill saved Europe from itself, and the UK has this role again.
The UKs International Trade Secretary Anne-Marie Trevelyan also said that Brexit had helped the countrys response in enabling the UK to cut tariffs on Ukrainian goods.
She told Politico last month that this had been achieved through the free-trade agreement that was executed at pace.
This move was made before the EU proposed the same key decision, something that would have previously been impossible.
Head of the UK in a Changing Europe think tank, Anand Menon, said Brexit Britain would want to beat the EUs response to the crisis.
He explained: The politics of Brexit meant that the Government wanted to be out there and being seen. It has a political point to prove.
Ukrainian President Volodymyr Zelenskyy has praised Mr Johnsons response and support for his country on several occasions.
He said the UK Prime Minister is a leader who is helping more than some EU counterparts, condemning those who have been slow to cut off Russian energy supplies which continue to fund the conflict.
Mr Johnson addressed the parliament in Kyiv via video link from London on Tuesday, May 3, and pledged a new package of support for the country with supplies arriving in the coming weeks.
So what do YOU think? Has Brexit helped in the fight against Putin and in supporting Ukraine? Vote in our poll and leave your thoughts in the comment section below.
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Brexit POLL: Has EU exit helped in fight against Putin and to support Ukraine? - Express
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