Daily Archives: May 3, 2022

As PopSci turns 150, we reflect on the highs and lows of our long history – Popular Science

Posted: May 3, 2022 at 10:14 pm

The work of creating science has been organized for centuries, wrote Popular Science founder Edward Livingston Youmans in his inaugural editors note in May 1872. The work of diffusing science is, however, as yet, but very imperfectly organized, although it is clearly the next great task of civilization.

Over the last 150 years, the editors of Popular Science have published 1,746 issues (very soon to be 1,747), countless web articles, hundreds of videos, and more in our continuing effort to answer that charge: To as perfectly as we can organize the world of scientific inquiry and innovation for curious everyday people as best we can. Or, as Youmans put it, for whoever cares how opinion is changing, what old ideas are perishing, and what new ones are rising into acceptance.

Youmans believed that the US was home to many such curious minds, and that they would only become more numerous in the future. Within just a few years, he was proven correct. Circulation of the periodical grew to 11,000 by the end of 1873 and had reached 18,000 by the time Youmans died, in 1887, at the age of 65. (His brother and collaborator, William Jay Youmans, took up editorship through 1900.) Today, Popular Science reaches an audience of millions across our varied platforms.

At Youmans behest, the publication came into existence at a pivotal moment in the history of science and invention. Then called The Popular Science Monthly, the magazine entered a world where a growing repository of scientific knowledgeone that included vaccines, telegraphs, electricity, locomotives, typewriters, industrial machines like lathes and drill presses, and new materials like vulcanized rubberwas poised to impact everyday life. The barrier between laboratory science and applied science was vanishing. New work quickly spurred more work and fresh experimentation, a dynamism that demanded rapid interpretation.

Youmans implored his authors, most of whom were among the eras most prominent practicing scientists and philosophers, to translate their work into language those outside their fields could more readily understand. Eight-tenths of the patrons of the Monthly will get but a partial comprehension of it, he wrote in a letter to an author explaining his need to edit out jargon in an article about new concepts in mathematics. (A predecessor of mine called this drive to distill complexity without sacrificing accuracy radical clarity, a phrase that has echoed in my brain for some 13 years.)

So it was until the early 1900s, when a change in publisher opened up an iconic period for PopSci, one with vibrant, illustrated covers and images showcasing rapid progress. Editors sought to not simply explain the present, but explore visions of the future. Our early years trotted out a series of world-changing firsts: phone calls, radios, flights, atomic bombs, automobiles, television. By the mid-century, with World Wars in the rearview, the editors began to imagine a world of buzzing metropolises, flying cars, and, of course, personal jetpacks.

If Youmans initial goal was to educate his audience, then here began a phase of aspiration: a shared ideal that science and technology were funnels to a better, safer, healthier, happier, more exciting existence.

In the years since, editors have dubbed PopSci The Whats New Magazine and adopted taglines like The Future Now. But the Popular Science of 2022 does not exist purely in either the educational or the aspirational realm.

Since our Last Big Anniversary Year (number 125, in 1997), weve experienced a paradigm shift in the role of science in everyday life. In June 2007, Steve Jobs showed the world the iPhone for the first time, setting in motion a change in the average persons daily interface with technology and information. Our collective ability to findand sharethat information with such great ease has made parsing the clamor more difficult than its ever been.

We still believe in a better futurea relentless optimism that sees the potential to make good out of even our toughest challengesbut the Popular Science of the COVID-era world is first and foremost a lighthouse of the now. In many ways, weve gone back to the basics, which has invited a few barbs about how PopSci now cares more about being popular than about science. When you look closely, however, what weve actually done is fully embrace what the word popular really means.

To the current generation of Popular Science editors, popularity means meeting people where they are, and introducing them to scientific concepts through the lens of their own daily experiences. It means satisfying a universal sense of wonder that subtly reminds everyone that were all beneficiaries of scienceand that most of us, whether we realize it or not, are already big fans of it too. It also means ensuring our work speaks to the population not as a homogeneous mass, but as a diverse bunch with shared needs and interests. And many different ones too.

We only wish wed gotten here sooner.

Paging through our early days puts us face-to-face with representations were not proud of. World War II provides a particularly potent example, as caricatures of enraged Japanese pilots stand in stark contrast to stately depictions of American victors. (In 1945, the editors, we must note, made no celebration in their commentary following the bombings of Hiroshima and Nagasaki.) After the War, our view of life at home painted whats now a reductive, discriminatory picture, casting women as homemakers and people of color as domestic workers. A modern eye will even find sexism encoded in articulations of our mission, championing that the man who masters a balky furnace and the woman who bakes a better muffin are often unconscious scientists in a May 1947 75th anniversary retrospective.

Our publication has also contributed to egregious wrongs. It could be argued, for instance, that our founder was integral to the dissemination of social Darwinism in the US. British philosopher Herbert Spencer, a contemporary of Darwin who coined the phrase survival of the fittest in his 1864 book Principles of Biology, applied ideas about evolution and inheritance sociologically: He offered that those who thrive in society deserve their wins while those who flounder have earned their losses. Youmans zeal for his work led to its publication in our first issue, and nearly a dozen times after.

Spencers ideasand related interpretations of Darwins theory of evolutionwould inform a chilling era in American science.

Around the turn of the 20th century and into the early 1900s, Popular Science lent credence to the eugenics movement, a field of study that proposed a path to perfect civilization through selective breeding. Now rightly regarded as bigotry under a veneer of pseudoscience, the ideology applied advances in our understanding of evolution and genetic inheritance to support racist, sexist, and xenophobic policies that disproportionately impacted Black, Latinx, and Indigenous people. Eugenicists pushed through laws that allowed states to forcibly sterilize persons deemed feeble-minded and legislation that excluded certain nonwhite immigrants. Searching the first 25 years of our archive nets dozens of articles presenting supposedly scientific arguments for such practices. Historians now widely accept that American eugenics had an outsize impact on the genocidal policies of the Nazi party.

In eugenics, PopScis founding writ to deliver science to the public was also our Achilles heel. Our continued coverage of the field and its proponents only served to normalize the idea. In 1923, Senator Arthur Capper of Kansas washed the practice as the science of fitter families in an article recounting eugenic successes in the state. A 1925 dispatch from Chicago described with fanfare a device that could predict the inheritance of criminal behavior. As recently as 1962, a retrospective we published highlighted the movementthis time citing proof of eugenic ideas allegedly observed within a particular South African tribewithout critical comment.

Investigating ugliness in our past is a vital part of our future. In addition to deciphering the world of science for everyday readers, it has long been part of our ethos to embrace and explore faultsand to be constructive as we chart a path forward. In our last quarter century, for instance, the distasteful eugenic period has driven us to bring greater cynicism to topics from DNA sequencing to designer babies. And coverage in the magazine and on popsci.com under the current generation of editors has broadened its focus to explore how racism continues to pervade in science and society, including in drug criminalization, environmental destruction, and inequities in public health.

This month were continuing that work by introducing a series called In Hindsight: a collection of stories highlighting researchers from the last 150 years whose contributions are missing from our pages, but who deserve recognition. In our 75th anniversary retrospective, editors trumpeted a roster of 12 white men who helped popularize science. Were only just beginning to fill in the gaps. Some of the great minds well showcase, like microbiologist Esther Lederberg, made key contributions to prizewinning work, while others, like physicist Caroliyn Beatrice Parker, had their brilliance cut short by barriers of sexism and racism.

These profiles also include the story of our founders sister Eliza Ann Youmans, a botanist and textbook author. Elizas contributions to her brothers early work and PopSci are by no means a secret: His biographers regularly note that she was his reader and scribe during a period of blindness in his twenties, and she penned numerous articles and reviews for the magazine, including his obituary. But generally speaking, we know precious little about her and the extent to which her influence may have shaped and marked the brands earliest years.

While we know its important to embrace our shortcomings, theres certainly more in our history to be proud of than not. Over the decades, we successfully delivered dispatches on sciences watershed moments and the stories of the scientists behind them. In 1883, we published the revolutionary idea that microscopic germs, not bodily impurities, caused disease. In 1931, a Popular Science reporter was there when Auguste Piccard became the first person to reach the stratosphere (we also watched when Felix Baumgartner jumped from those same heights in 2012). And, in 1984, we were among the first to get up close with Steve Jobs and his new Macintosh computer. This month, well be resharing one such story every weekday, providing a tour through world-changing breakthroughs like Salks polio vaccine and allowing readers to peek into the pastand the marvelous visions it held of our future.

Over the coming months, well also be checking in on our progress toward some of innovations most-compelling ideas in the Are We There Yet? series. Here, well assess the realities of those visions and gut-check their feasibility, practically, and necessity. Weve been wondering, for example, if medical science will find a cure for aging since at least 1923, asking when artificial smarts will supplant baseball umpires since 1939, envisioning cities with complete streets since 1925, and questing after airplanes that fit in household garages since 1926.

Of course, wed be giving PopScis founding legacy short shrift if we didnt also look at the scientific moment were in nowand speculate smartly on what the future might hold. On May 17, well drop our Summer digital issue, which explores the current state of technology through our species ever-changing relationship with metal. Central to that is our current tug-of-war with the conductive elements we need to power a wave of electrification. On the same day, were also publishing a special newsstand-only print edition that calls on 50 visionariesfrom neuroscientists to sci-fi authorsto gaze into the next 150 years and tell us what they see.

Popular Science, even after 150 years, is not unlike those visions: a work in progress. Itd be an act of great hubris to claim weve reached the goal post our founder set of perfectly organizing the dissemination of science. To claim otherwise would be unscientific. One of Zenos great paradoxes, after all, holds that its impossible to close the gap between two things. What we can claim, however, is increasingly rapid progress toward that North Star.

Check out all our anniversary coveragehere.

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As PopSci turns 150, we reflect on the highs and lows of our long history - Popular Science

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In a field of its own, Food in the Field provides healthier on-the-go eating choices – Nebraska Today

Posted: at 10:13 pm

Lincoln, Neb. Just four short years ago,Food in the Fieldwas a hypothetical program on Hannah Guenthers Nebraska Extension application aimed at reaching bachelor farmers to guide them in making quick, easy and portable meals.

Fast forward to 2022, and Guenther, a food nutrition and health extension educator in Cuming County, has managed to build a nutrition education with a goal to help on-the-go adults and their families make healthier eating choices during busy seasons.

Food in the Field is a series of tools to provide all the information you need to make small shifts in the diet and implement healthier eating practices into your daily routine, says Guenther.

Food is one of the most enjoyable parts of life, the highlight of everyones day and in no way is this program going to tell you to overhaul your diet. Im never going to tell someone they cant or any food is off limits.

Since starting her career with Extension, Guenther has transitioned to the country life, moving to her husbands operation, a farming and cattle feeding enterprise near West Point.

Knowing Nebraskas largest economic driver was the agricultural industry and transiting her new life on the farm, Guenther says the driving force behind Food in the Field was her first-hand experience with her husbands eating habits, and how they changed during especially busy times of harvest and planting.

Pictured above is Hannah's husband Adam, holding an on-the-go lunch in the cab of his tractor.

When I started in Extension, never in a million years did I think Id want my focus to be feeding farmers, but that is what Ive realized Im so passionate about, said Guenther.

I have never gone down this path without marrying my husband, and I dont think I would care as deeply had I not moved into a rural community and being surrounded by it on a day-to-day basis.

Her new role living and working in a rural community was a stark contrast to her upbringing in Texas, where agriculture was not at the forefront of her life. Guenther became particularly attuned to the 18+ hour workdays of her husband, the busy seasons of planting and harvest, as well as stressful weather patterns, markets and policies.

With limited healthy options in the rural community and plentiful convenience food options, Guenther says she experienced first-hand how easily healthy eating was put on the back burner for her husband and for others living a modern on-the-go lifestyle.

After the local hospital reached out to her for assistance with nutrition education, Guenther was off on a mission to provide valuable tools to help others make healthychoices for the busy seasons as well as in everyday life.

Living in a rural community, I see these people daily. My husband loves his job managing the feedlot, and it makes me happy to see how happy he is, Guenther says. How can I take care of these people? I want them to be able to do their job to the best of their ability every single day. How can I do that? Thats been my focus.

With the intention of taking care of producers and helping them to be healthier, Guenther was shocked to find scarce research on the diet of agricultural producers despite extensive studies of farm safety and mental health related to the field. Seeing a disconnect and underserved audience, Guenther launched Food in the Field in 2018 with a goal to place a greater focus on feeding those who feed us.

Guenther says she also wants to help others go through the transformation she went through as she adjusted to rural living, coming from the city with little exposure to agriculture.

I was really worried about moving to my husbands feedlot, and it was a really big learning curve for me at first. Every day I learn something and see the care farmers not only put into the land and livestock, Guenther says.

I want people to have a better connection with the ag industry and Ive tried to highlight the work of the industry with what I do on a daily basis.

Thats the genesis of Guenthers Instagram platform,feedlotsofpeople, which she started completely unrelated to work when she realized everyone was looking to their phones for nutrition information.

While she says it began purely as a recipe file, it has evolved into a place centered around nutrition education recipes from Food in the Field, as well as a look into where food comes from and her daily life raising her family in agriculture.

Her work with Nebraska Extension and social media platforms is a natural combination of her passion for cooking and providing palatable pieces of nutrition education information in an aesthetically pleasing way.

Taken from her Instagram page, Hannah shares a recipe of a nutritious, yet delicious smoothie recipe fit for anyone.

Food in the Field has reached over 280 people at in-person events and nearly 300 e-newslettersubscribers, and her Instagram profile is nearing 4,000 followers.

If you are interested in having Food in the Field be a part of your next meeting, program, or conference, contact Hannah and Tara by going to food.unl.edu/foodinthefield.To continue sharing relevant information withrural communities, they created an e-newsletteras an extension of Food in the Field. To receiveresearch-based resources, recipes & helpful tips directly in your e-mail inbox,subscribe by clickinghere!

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Dianthus Therapeutics Launches with $100M to Develop Selective Antibody Complement Therapeutics to Treat Severe and Rare Autoimmune Diseases – Yahoo…

Posted: at 10:13 pm

Lead program DNTH103 to be accelerated to the clinic this year as a highly differentiated and potent monoclonal antibody designed to selectively target the active form of complement C1s

Led by biotech veterans Marino Garcia as Chief Executive Officer and Lonnie Moulder as Chairman of the Board

Financing co-led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company with strong investor syndicate

WALTHAM, Mass. and NEW YORK, May 3, 2022 /PRNewswire/ -- Dianthus Therapeutics, a biotechnology company dedicated to advancing the next generation of antibody complement therapeutics, today announced the completion of its $100 million Series A financing led by 5AM Ventures, Avidity Partners, and Fidelity Management & Research Company, with participation from additional investors including Wedbush Healthcare Partners and founding investors Fairmount, Tellus BioVentures, and Venrock Healthcare Capital Partners. The financing will be used to expand leadership and scientific teams, advance the company's lead program, DNTH103, to the clinic this year, and to accelerate additional discovery pipeline programs for people living with severe and rare autoimmune diseases. DNTH103 is a potent, next-generation monoclonal antibody that selectively targets the active form of complement C1s, potentially enabling a lower dosing volume and a less frequent subcutaneous administration that is further enhanced with half-life extension technology.

Dianthus Logo

Dianthus also announced the appointment of Marino Garcia as President and Chief Executive Officer, joining in November 2021, and Simrat Randhawa, M.D., M.B.A., as Chief Medical Officer. Mr. Garcia, a veteran dealmaker and strategist, brings more than 25 years of industry experience in business development and operational leadership roles at top biotech and pharma companies, most recently as Senior Vice President, Corporate and Business Development at Zealand Pharma. Dr. Randhawa brings over 20 years of clinical practice and pharmaceutical industry experience to Dianthus, including senior leadership roles focused in the autoimmune and rare disease spaces. He most recently served as Senior Vice President of Clinical and Medical Affairs at Aurinia Pharmaceuticals.

"We are committed to improving the lives of people living with severe and rare autoimmune diseases and are confident that our selective antibodies have the potential to be best-in-class therapeutics," said Marino Garcia, President and Chief Executive Officer, Dianthus Therapeutics. "We are privileged to have a strong syndicate of leading biotech investors, experienced Board members, and accomplished leaders and scientists as we advance our lead candidate into the clinic later this year, further develop our discovery pipeline, and expand our team in the coming months. Dianthus is positioned to become a leading, next-generation complement company guided by a deep understanding of the needs of patients."

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Dianthus harnesses the power of selectivity in complement pathways to create potent monoclonal antibodies with the potential to overcome the limitations of current complement therapeutics. Unlike current antibody therapies that bind to both inactive and active complement proteins, DNTH103 selectively targets only the active form of the C1s complement protein, enabling a lower dosing volume and less frequent administration. Its half-life extension technology also further reduces dosing frequency. With these differentiated attributes and high potency inhibition of C1s, DNTH103 is designed to relieve the burden of high-volume, frequent administration with IV infusions or inconvenient, frequent subcutaneous dosing. Accelerating the development of a more convenient subcutaneous therapy could be transformative in expanding the potential patient populations that could benefit from complement therapies, while reducing the discomfort and disruptions that pervade the lives of patients today ultimately allowing more patients to live healthier lives to their fullest potential.

"We are proud to support Dianthus Therapeutics in advancing the discovery and development of next-generation, potent, and highly differentiated antibody complement therapeutics," said Paula Soteropoulos, Board Director of Dianthus and Strategic Advisor to 5AM Ventures. "With the leadership of the recently appointed President and CEO Marino Garcia, and a talented team of seasoned biotech executives and entrepreneurs who hold an extensive track record of success, we look forward to seeing Dianthus bring their novel therapies to patients living with severe and rare autoimmune diseases."

Dianthus is currently led by an accomplished team of veteran scientists and biotech entrepreneurs, including:

Marino Garcia, President and Chief Executive Officer

Simrat Randhawa, M.D., Chief Medical Officer

Evan Thompson, Ph.D., Chief Operating Officer

Edward Carr, Chief Accounting Officer

Rivka Gluck, Senior Vice President, Head of Clinical Operations

Robert McGarr, Ph.D., Vice President, Program & Alliance Management

Kristina Maximenko, Head of Human Resources

Dianthus is also supported by an experienced Board of Directors, including:

Lonnie Moulder, Chairman of the Board at Dianthus, Founder and Managing Member of Tellus BioVentures

Paula Soteropoulos, Chairman of the Board at Ensoma and former CEO of Akcea Therapeutics

Lei Meng, Senior Therapeutics Analyst, Avidity Partners

Tomas Kiselak, Managing Member of Fairmount

Jonathan Violin, Ph.D., Co-founder and Chief Executive Officer of Viridian Therapeutics

Marino Garcia, President and Chief Executive Officer, Dianthus Therapeutics

Jefferies LLC served as financial advisor to Dianthus.

About Dianthus Therapeutics

Dianthus Therapeutics is a biotechnology company dedicated to designing and delivering novel, best-in-class monoclonal antibodies with improved selectivity and potency over existing complement therapies. Based in Waltham, Mass. and New York City, Dianthus is comprised of an expert team of biotech and pharma executives who are leading the next generation of antibody complement therapeutics to deliver transformative medicines for patients with severe and rare autoimmune diseases. To learn more, please visit http://www.dianthustx.com.

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Evolution of the trapezoidal thread: new igus standard achieves 82% efficiency – Process & Control Today

Posted: at 10:13 pm

03/05/2022 igus UK Ltd

Harmonised lead screws and lubrication-free lead screw nuts in trapezoidal threads extend service life by 30%.

Motion plastics specialist igus has refined the classic trapezoidal thread, achieving a 30% service life extension a huge increase for a well-established mechanical part. Thanks to a special geometric interaction between the lead screw nut, which requires no lubrication or maintenance, and the metal lead screw, dryspin technology promises a long service life, improved efficiencies, reduced wear and quieter operation. And now dryspin lead screw technology is available in eight new sizes.

Trapezoidal threads have been classical mechanical engineering designs for decades. The machine elements convert rotary motion into linear motion in applications such as window and door drives, format adjustments in production plants and laboratory technology. However, almost every classic design has the potential for improvement. "We have tackled a market standard and are able to say that we can do even better," says Robert Dumayne, drytech director at igus UK. The igus design relies on an optimised interaction between the metal lead screw and the plastic lead screw nut geometries.

30% longer service life, 82% efficiency

Both the nut's thread flanks and the width of the lead screw are larger than those of classic trapezoidal thread. This is a small change, but it has big consequences: enlarging the thread flank means that more high-performance plastic is used for power transmission. This means more material that is tribologically optimised, i.e., reducing friction and wear. "The asymmetry has enabled us to extend the service life so that it is about 30% longer than that of symmetrical trapezoidal threads", Dumayne says.

He adds Optimising the flank angle also increases the amount of energy supplied that is actually used. We have flattened the flank angles of the lead screw nut and lead screw, this gives us above average efficiency up to 82% at high pitches."

Lead screws work almost silently and without vibration

The new dryspin thread technology is not only durable and efficient, but also quieter than many conventional trapezoidal threads, because the tooth flanks are not angular but rounded, reducing the contact area between lead screw nut and lead screw. This leads to less vibration, which can take the form of rattling or squeaking. Dumayne says: "The rounded tooth flanks allow the lead screws to move without vibration and almost silently. The lead screw manufacturing tolerance is tighter than that specified in DIN1037e, ensuring more precise operating behaviour and allowing for much higher speeds in the application."

Eight more installation sizes added to the dryspin lead screw portfolio

igus began to establish its own lead screw technology on the market in 2013, initially as an alternative to high helix threads. Now there are eight new installation sizes both harmonised lead screws and lead screw nuts, including dimensions with low pitches that enable quick one-to-one replacement of installed trapezoidal threads.

The new lead screws are available with pitches of 6.35x6.35RH, 8x40RH, 10x3LH, 12x25LH, 14x4RH, 16x5RH, 18x4RH and 20x10RH. They are made of stainless steel or aluminium, and the lead screw nut material can be selected from seven high-performance plastics and several geometries from a cylindrical design with flange or spanner flats to a version with spring pre-load.

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South32 boosts Brazil green aluminum supply with bauxite mine buy – MINING.COM – MINING.com

Posted: at 10:13 pm

The attributable production from the Par state operation is expected to satisfy the companys internal bauxite requirements. In addition to South32s 33% stake in the MRN mine, it holds a 36% share of the Alumar alumina refinery and a 40% stake in the aluminum smelter.

MRNs open-cut strip mine produces 18 million tonnes of bauxite a year, supplying the Alumar refinery (capacity of 3.5 million tonnes per annum) and smelter (440,000 tonnes per year).

South32 CEO Graham Kerr said in a news release that the increased stake in the mine was an essential step as the company worked with its joint venture partners to complete a pre-feasibility study (PFS) for the MRN life extension project. The redevelopment project could potentially extend the life of the 40-year-old mine by more than 20 years.

The PFS is slated for completion by the first half of 2023.

As a result of our investment in Brazil, including participation in the restart of the Alumar smelter using 100% renewable power, our planned increased shareholding in Mozal aluminum, which benefits from access to hydroelectric power, we expect to double our production of green aluminum by 2023, said Kerr.

In January South32 announced plans to participate in the restart of the Aluminar smelter along with joint venture partner Alcoa. The smelter is expected to reach full capacity from its three potlines of 447,000 tonnes per annum in the first quarter of 2023. The first production from this facility is expected by June.

South32s 40% stake in Brazil Aluminium will be powered by renewable energy. According to the CRU aluminum cost model for 2021, the smelter placed in the second quartile of the global aluminum site cost curve.

Aluminum is a critical future-facing metal made via a two-step process. It entails mining bauxite an aluminum ore and crushing and refining the ore into a white alumina powder before the white powder is smelted into aluminum metal.

In addition to operating the Mozal Aluminium plant in Brazil, South32 also operates the Hillside Aluminium smelter in South Africa the largest aluminum smelter in the southern hemisphere.

Despite coming off recent highs, South32 shares quoted in Sydney at A$4.77 at close on Monday have advanced nearly 66% over the past 12 months, giving it a market capitalization of A$22.16 billion ($15.64 billion).

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Withania Somnifera Extract Market 2022 by Manufacturers, Regions, Type and Application, Forecast to 2028 |Life Extension, Taos Herb Company, General…

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Market Segment By Type: Capsule LiquidMarket Segment By Application: Health Products Drug

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Viridian Therapeutics to Report First Quarter 2022 Financial Results and Host Conference Call on May 12, – Benzinga

Posted: at 10:13 pm

WALTHAM, Mass., May 03, 2022 (GLOBE NEWSWIRE) -- Viridian Therapeutics, Inc. VRDN, a biotechnology company advancing new treatments for patients suffering from serious diseases underserved by current therapies, today announced it will report its financial results from the first quarter ended March 31, 2022, after the financial markets close onThursday, May 12, 2022.

The Company's management team is scheduled to host a conference call at4:30 p.m. ETonThursday, May 12, 2022. To access the call, please dial 1-877-270-2148 in theU.S.or 1-412-902-6510 outside theU.S.and ask for the Viridian call. To access the live webcast, please visit the "Events" page in the Investors section of the Viridian Therapeutics, Inc. website. Following the live webcast, an archived version of the call will be available on the website.

Thursday,May 12@4:30 p.m. ET

About Viridian Therapeutics

Viridian Therapeuticsis a biotechnology company advancing new treatments for patients suffering from serious diseases but underserved by today's therapies. Viridian's most advanced program, VRDN-001, is a differentiated monoclonal antibody targeting insulin-like growth factor-1 receptor (IGF-1R), a clinically and commercially validated target for the treatment of thyroid eye disease (TED). Viridian's second product candidate, VRDN-002, is a distinct anti-IGF-1R antibody that incorporates half-life extension technology and is designed to support administration as a convenient, low-volume, subcutaneous injection.TED is a debilitating autoimmune disease that causes inflammation and fibrosis within the orbit of the eye which can cause double vision, pain, and potential blindness. Patients with severe disease often require multiple remedial surgeries to the orbit, eye muscles and eyelids. Viridian is based in Waltham, Massachusetts.

Investor and Media Contact:John JordanViridian TherapeuticsVice President, Investor Relations& Corporate Communications617-272-4691IR@viridiantherapeutics.com

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Viridian Therapeutics to Report First Quarter 2022 Financial Results and Host Conference Call on May 12, - Benzinga

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Achilles, Lister & Jesse Lee Thetford Link For New Take On Trance Classic As The Rush Comes’ – CULTR

Posted: at 10:11 pm

Taking on a trance classic is no easy feat, but for Australian producers Achilles and Lister, theyve taken it in their stride and given the iconic anthem a fresh new spin, with help from US based vocalist Jesse Lee Thetford.

As The Rush Comes, was originally released in 2003 by Motorcycle (trance duo Gabriel & Dresden with vocalist Jes) and was a sure fire hit within the dance music world and beyond, with the original track still receiving attention today, almost 20 years on.

Achilles and Lister inject a vibrant and hard hitting feel into the classic anthem, managing to hold onto the lively, uplifting nature of the original, whilst subsequently polishing the record with their own flavor. Starting off with a hard hitting main room trance drop that perfectly complements Jessies vocal, the break is the zenith of the track, as it builds with the vocal and travels into a goosebump-inducing lead and future rave-esque final drop, resulting in a grand, climactic close.

Achilles and Lister, both being in Melbourne, saw their similarities and passion when it came to music and immediately got working. As The Rush Comes is just the first of many records the talented pair have cooked up in the studio. Between the artists, theyve recently been supported by the likes of Hardwell, Tisto, Armin van Buuren, Timmy Trumpet, W&W and Afrojack.

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Achilles, Lister & Jesse Lee Thetford Link For New Take On Trance Classic As The Rush Comes' - CULTR

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Lessons of Trump’s Unknown 1st TV Project – The Washington Spectator

Posted: at 10:11 pm

Is it still acceptable to be fixated on Donald Trumps iron grip on millions of Americans? While most people seem to have moved on, Id argue that getting to a true understanding of his appeal is still of vital interest. Indeed, peoples lives may depend on it. Election officials continue to receive death threats for challenging his election lies. A large-scale violent insurrection appears plausible if he loses again in 2024.

We should not buy into simplistic explanations like Theyre all racists or He starred in a hit reality TV show. Something much more profound is at work. One half of the country perceives Trump to be an incompetent and psychologically troubled man of dubious achievements. The other half sees him as the only human being on the planet who could ever solve their problems. Many of these appear ready to kill and die for him.

To understand this astonishing perceptual divide, we need to revisit what we think we know about television as a medium. When we talk about reality TV, we owe it to ourselves to investigate our conceptions of reality and TV, both of which have evolved significantly in the last decade or so. Trumps impact on television audiences is related to profound changes in the medium itself. These changes have occurred slowly enough to escape serious notice by people who want to understand how a talented performer like Trump can gain such influence over people. While television is not the only factor that explains Trumps grip on his supporters, it is arguably the most important, especially when assessing his early popularity with voters.

The roots of todays competing realities lie in the evolution of reality television itself and its effects on viewers brains. This is a story that starts in the early 1960s; a story I participated in as my career progressed from producing made-for-TV movies to serving as Social Software Evangelist at IBM.

In the summer of 1960, the French filmmaker Jean Rouch, who had spent the previous decade making documentaries about African tribes, took his portable clair Cameflex 16-millimeter movie camera out onto the streets of Paris to interview real people in their daily lives. The resulting film, Chronique dun t (Chronicle of a Summer) was both a technical and artistic breakthrough. The equipment was revolutionary. No sound camera had ever been so portable. Also revolutionary was the idea of making a movie about regular people just casually talking about the issues of the day, such as the French colonial war in Algeria. It was one of the first cinema verit films.

The whole purpose of cinema verit was to be real. The filmmaker would always have a point of view, and there is no such thing as true objectivity, but the goal was to record reality as it was, with as little interference as possible.

This cinema of truth or observational cinema existed mostly in the realms of public television and art house documentaries, with a few breakouts like Michael Wadleighs Woodstock and PBSs An American Family achieving popular success. At the same time, the verit technique was establishing itself in the mind of the audience as a window onto reality. The effect emerged mostly from the use of the verit style in television news, with portable cameras bringing us film at 11. This perception, that informal filming of real people reflected reality, would have major implications for television as a mediumand also, as we would later discover, politics.

My involvement with verit came 25 years after Jean Rouch hit the streets of Paris with his clair camera. After studying with some of cinema verits most celebrated practitioners, I took a job in primetime television. My mentor was Edgar Scherick, the fiery-tempered former president of ABC. In the 1950s, Edgar had created The Wide World of Sports. He went on to produce dozens of television movies and feature films like The Stepford Wives and The Taking of Pelham 1-2-3. Later, hed brought an unknown 19-year-old New York casting director named Scott Rudin to Hollywood.

By 1988, when I joined his production company as a cigar-fetching assistant, Schericks main gig was dramatizing true stories as made-for-TV movies. This was a format that, in retrospect, was a bridge between traditional, completely fictitious television and what we now consider reality TV.

Though now extinct, the true crime movie of the week was a reliable source of high ratings in the 1980s and early 90s. Every network made it a staple of their programming schedules. No one could adequately explain why the audience was so hungry for true crime docudramas. One theory, which I am skeptical of, was that people tended to feel guilty about watching TV, so they rationalized consuming endless gore and dramatizations of depraved behavior with the excuse that they were informing themselves about the news of the world.

I suspect audiences were actually getting trained to view docudramas as inherently true. The barrier between reality and fiction, what I would call the fifth wall of onscreen programming, was beginning to crumble. Most films and TV shows respect the three walls of the stage set, with the fourth wall functioning as an invisible barrier between the camera and the action. Sometimes, an actor will break the fourth wall and speak directly to the camera. This is common in reality TV, but more and more, as time went on, the fifth wall also began to deteriorate.

Probably the first serious erosion of the fifth wall came in 1989 as the cinema verit genre enjoyed its first major primetime hit with Cops, on the Fox Network. Scherick worked on a project with the producers of Cops. It was in this context that I learned Cops was betraying cinema verits most sacred rule of not interfering in the subjects life.

This bothered me, though its hilarious in retrospect that I was upset that Cops was staging confrontations between real people to get tape of entertaining arguments. What did I expect? This was hardly the Cinmathque Franaise. This was TV, produced for commercial entertainment and beholden to no rules about telling the truth.

The problem was that Cops looked like pure, unaltered real life. The audience got to ride along in cop cars and see the police at home with their families. The audience learned that an exciting TV show could be about real people, taped living their everyday lives. The show was trading on the belief that unposed, poorly lit and seemingly unscripted video reflected real life. It had the film at 11 look, so it had to be true, right?

I dont mean to imply that TV viewers are so ignorant that they cant tell the difference between fiction and reality. Subsequent reality programming has been transparently fake, with ordinary people set in highly contrived and obviously scripted scenarios. Its called scripted reality programming, an oxymoron that bothers no one. The audience today knows it is watching real people staging fake scenes. At the level of brain function, however, the distinction has been blurred.

This insight is critical if you want to understand Trumps power over his audience, especially early in his rise. If youve ever felt dizzy watching a car chase scene, youll understand that our brains tend to process events on a screen as if they were really happening to us. This is a well-documented neurological phenomenon. Jean Rouch called it the cin trance a state of mind where your brain is in the scene youre watching. You really are there, walking with him on the streets of Paris in 1960.

The verit trend in reality television also eroded the boundaries of exploitation and voyeurism in the medium. Watching dramatizations of true crime stories whetted the audiences appetite for voyeuristic glimpses through the curtains of their unfortunate neighbors. The reality TV movement served the main dish: a voyeuristic spectacle of sadism. Americans might have once felt guilty about enjoying a show like The Apprentice, which reveled in humiliating people, or American Idol, which glamorized the abuse of the weak. As the reality trend wore on, audiences were given permission to enjoy others misery as entertainment and protagonists like Trump were given a pass for being ruthless and denigrating. Trump is a true master of this art form.

Rouchs cin trance is a nave notion compared with the immersion in manufactured reality that American TV audiences experience today. News channels are designed to entertain. Theyre bracketed by hours of scripted reality on the programming schedule, and its all punctuated by commercials that feature unreal effects like talking batteries. The cin trance has morphed into a permanent TV trancea state of mental suspension in which the action on screen is perceived as reality, and therefore true, even if the conscious mind is aware that its fictionmade up and manipulative.

The experience of watching TV has also fused with reinforcing technology habits such as Twitter and Facebook. Audience members continuously trigger addictive centers in their minds with integrated loops of television programming and follow-on tweets and social media posts. YouTube and Instagrams ubiquitous mobile phone videos compound the effect. Were addicted to media stars we know are fake but neurochemically perceive to be real.

Trump was a force in this trend, as well as one of its main beneficiaries, as are Oprah, The Rock, and other fantasy presidential candidates who present fictional projections of themselves in the media. By 1990, Trump had become interested in being on television. Having gone bankrupt from the failure of his Atlantic City casinos, with creditors and law enforcement nipping at his heels, he needed a new way to make money. It was time for him to become rich by being famous, as he could no longer get famous from being rich.

Trumps attorneys reached out to Scherick, then one of the highest-profile go to people in the industry, and struck a deal for one of Donald Trumps first TV projects. It was to be called Trump Tower, a nighttime soap opera on NBC pitched as Dynasty meets the Algonquin Round Table.

We hired Clare Labine, co-creator of Ryans Hope, to write the pilot, which would take the form of a four-hour miniseries. The idea was to present a byzantine melodrama among sophisticated New Yorkers who lived in Trump Tower: major artists, prominent authors, tycoons...all sleeping with each other while hatching diabolical plots of sadistic revenge and schadenfreude for past betrayals.

In the background would be Donald Trump, playing a fictitious character named Donald Trump. He would be Donald Trump, the well-known real estate magnate, but with his lines written for him. He was envisioned as a sort of quiet Machiavellian character, moving the chess pieces of peoples lives around without their knowing it.

After the project began, Scherick got another call from Trumps lawyers. There was an actress named Marla Maples who would need to have a role in the series. The mistress, Edgar had murmuredThe lawyers hadnt said it out loud, but their intent was clear.

The show never got on the air, but from the perspective of 2022, its an informative missing link in Trumps biography. He later landed a hit with The Apprentice, which again featured him playing a fictional version of himself. This characterization of Donald Trump was of a powerful, decisive, and competent leader, a father figure who always knew the right thing to dodemonstrably the opposite of his true nature.

This is the Donald Trump his supporters admire. His characterization on The Apprentice differentiates him from other political figures who perform well on TV but simply cannot muster the audience buy-in that Trump easily commands. Its entirely a false persona, but the audience was never fully clued in on how much of the show was fabricated versus how much of it was real. And given the TV trance that had taken effect, it apparently didnt matter. People loved the show. They loved Trump and the tough, can-do character he played. Whatever their rational minds might have told them, their brain chemistry had them solidly believing he was the resolute, infallible master of their collective destiny. He was real, in their brains, even if they knew he was not. And he delivered the delicious helpings of sadistic voyeurism the audience so craved.

We know what happened next. Today, the country confronts a politician whose base thinks he can do no wrong. I suspect that they are to a large degree in the grip of the TV trance. Their deep brain functions are convinced that Donald Trump, the fictional TV character, is a real person with immense, unique powers, despite what observable reality might tell them.

As to what should happen now, I dont have any clever ideas. I do think that if there is to be any effective movement against Trump, it should consider the brain connection he has with his television audiences. Screaming youre a racist at his followers is not the answer. Instead, it might be more useful to engage and explore why they feel hes real in their hearts while they know hes not real in their heads. Such an approach would at least be moving along a path to the truth and to deconstructing the paradox of Trumps verit.

Hugh Taylor is a technology analyst and author of the book Digital Downfall: Technology, Cyberattacks and the End of the American Republic. Prior to working in the tech field, Hugh was a script development executive in primetime television.He studied filmmaking at Harvard University.

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Lessons of Trump's Unknown 1st TV Project - The Washington Spectator

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Paul Oakenfold: I’ve always been about trying to push the boundaries – We Rave You

Posted: at 10:11 pm

Paul Oakenfold recaps his career and the changes in the industry on The Spout PodcastLegendary Paul Oakenfold spoke to The Spout Podcast about his early career and said being challenged by the film industry was a real moment for me.

Paul Oakenfold is one of the most mythical figures in electronic music in the UK and the rest of the world. The three-time Grammy-winner is one of the most relevant players in trance and although he was part of the early chapters of the industry, today he continues to make his mark in the art that he seeks to preserve. Maybe none of this information is news to you, but did you know that it was the movie industry that helped Oakenfolds career to prosper? It was about this, and more, that the legendary artist spoke on The Spout Podcast.

The Spout Podcast is a weekly show where famous people talk about what made them famous and their passions beyond music. Its meaningful conversations that give you close access to the lives and careers of your favourite artists. The Spout Podcast is distributed to every major podcast platform, including Spotify, Google, iHeart, and Apple Podcasts. Paul Oakenfold was one of the most recent guests on the podcast and spoke with host Nick Major about his career, his new album and how he embraces the changes in the industry.

The music industry is where he belongs and where he has built an incredible career as a DJ, producer and trendsetter in dance music. However, the first steps were taken in the movie industry but not as an actor, make no mistake. Paul Oakenfold was challenged to write a song for a film that didnt exist yet and the result was the big hit Ready. Steady, Go which ran in the movies and was part of his debut album Bunkka in 2002:

Its a real moment for me () I was like, let me see if I can come up with an idea that works for a trailer, a film because Im a fan of films. So much so, that song appeared in Bourne Identity. I did a reworking of it for CollateralIts still being played now, and then it was in commercials. It was one of those songs. It just connected and happened.

In this interview, Paul Oakenfold also spoke about his recent album Shine On and how the pandemic turned out to be an opportunity for the British artist to complement his career with another brilliant piece of work. Prior to the pandemic creating in the studio was an almost impossible challenge, but the opportunity came out of the lockdowns:

Theres something positive that you can take from COVID because it was tough for all of us. And for me, it was time I had time to be in the studio to focus and work, and really think because there was nothing else to do.

Oakenfold also revealed some very interesting details about why he called his new album Shine On and much more, If you want to find out all of this, listen to the full interview below.

Paul Oakenfolds career is transverse to the analogue and the digital. The legendary artist has seen major changes in the industry in the last four decades, especially those related to technology. Oakenfold embraces the changes, always defending the importance of keeping the DJ art form alive. Beyond the technological revolution, he supports emerging artists, bringing many of them to his record label. But while change is necessary, one must be careful not to distort the industry:

I think youve got to embrace change. First of all, change is around us every day. Generally, we like to be in our comfort zones and we dont like change. You dont always like whats coming at you, especially technology was, I mean, the true art of DJ, and I always say to the young DJs who are signed producers or who I signed to my label that they really should go out and experience and see some of the greatest DJs out there.

Paul Oakenfold further adds that:

Ive always been about trying to push the boundaries. We can take the music out of the traditional setup. It doesnt just have to live in nightclubs.

Travel back in time with the legendary trance master as Paul Oakenfold recaps his sparkling career here below:

Paul Oakenfold (Press / via Insomniac)

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Paul Oakenfold: I've always been about trying to push the boundaries - We Rave You

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