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Daily Archives: March 21, 2022
Taraji P. Henson Uses Emmett Till As An Example To Demand Jussie Smolletts Release From Prison – Majic 102.1
Posted: March 21, 2022 at 9:09 am
One of the biggest things that fans loved about Lee Daniels hit FOX series Empire was the mother/son relationship displayed by Taraji P. Henson and Jussie Smollett as main characters Cookie and Jamal Lyon, respectively.
Following Smolletts real-life prison sentencing last week after being found guilty of staging a 2019 hate crime hoax, his former TV mom decided to defend the disgraced actor by calling for his release and using the sad case of Emmett Till as an example for her reasoning.
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Henson has joined the #FreeJussie movement started by his family in wake of Cook County Judge James Linns decision to give Smollett 150 days in jail, 30 months of probation and an order to pay $120,000 in restitution to the Chicago Police Department for overtime spent investigating the case. I am not here to debate you on his innocence but we can agree that the punishment does not fit the crime, Taraji wrote to begin a lengthy caption in defense of Jussie (seen above), going on to add, Emmett Till was brutally beat and ultimately murdered because of a lie and none of the people involved with his demise spent one day in jail, even after Carolyn Bryant admitted that her claims were false. No one was hurt or killed during Jussies ordeal. He has already lost everything, EVERYTHING!
Many have been taught since childhood about 14-year-old Emmett Tills gruesome 1955 lynching, an act that as of last week is now officially considered a hate crime thats named after the late teenage civil rights martyr. Although Taraji is quite bold to compare the actual crime of Tills death to a lie Jussie told for sympathy and fame, the core of her argument is that his lie was a victimless one. She concluded the caption by adding, To me as an artist not able to create that in itself is punishment enough. He cant get a job. No one in Hollywood will hire him and again as an artist who loves to create, that is prison. My prayer is that he is freed and put on house arrest and probation because in this case that would seem fair. Please #freejussie [sic].
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Overall, what Jussie is accused of doing should be taken seriously being that many real-life victims of racist and homophobic attacks may be met with skepticism as a result of his actions. Still, worser crimes have been committed with little to no legal ramifications (see: Kyle Rittenhouse).
Let us know if you agree with Taraji P. Henson or believe Jussie Smollett is getting his due punishment.
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The 50 Best Sci-Fi Books of All Time – Esquire
Posted: at 9:07 am
Since time immemorial, mankind has been looking up at the stars and dreaming, but it was only centuries ago that we started turning those dreams into fiction. And what remarkable dreams they aredreams of distant worlds, unearthly creatures, parallel universes, artificial intelligence, and so much more. Today, we call those dreams science fiction.
Science fictions earliest inklings began in the mid-1600s, when Johannes Kepler and Francis Godwin wrote pioneering stories about voyages to the moon. Some scholars argue that science fiction as we now understand it was truly born in 1818, when Mary Shelley published Frankenstein, the first novel of its kind whose events are explained by science, not mysticism or miracles. Now, two centuries later, sci-fi is a sprawling and lucrative multimedia genre with countless sub-genres, such as dystopian fiction, post-apocalyptic fiction, and climate fiction, just to name a few. Its also remarkably porous, allowing for some overlap with genres like fantasy and horror.
Sci-fi brings out the best in our imaginations and evokes a sense of wonder, but it also inspires a spirit of questioning. Through the enduring themes of sci-fi, we can examine the zeitgeists cultural context and ethical questions. Our favorite works in the genre make good on this promise, meditating on everything from identity to oppression to morality. As the Nobel Prize-winning novelist Doris Lessing said, "Science fiction is some of the best social fiction of our time.
Choosing the fifty best science fiction books of all time wasnt easy, so to get the job done, we had to establish some guardrails. Though we assessed single installments as representatives of their series, we limited the list to one book per author. We also emphasized books that brought something new and innovative to the genre; to borrow a great sci-fi turn of phrase, books that boldly go where no one has gone before.
Now, in ranked order, here are the best science fiction books of all time.
50The Echo Wife, by Sarah Gailey
Westworld meets The Stepford Wives in this gripping revenge thriller about the unlikely alliance between a woman and her clone. When geneticist Evelyn Caldwell learns that her husband Nathan is cheating on her, she soon ferrets out the truthrather than work on their strained marriage, Nathan stole Evelyns proprietary cloning technology and replaced her with a more docile substitute. But when Evelyn finds her clone standing over Nathans dead body, crying, It was self-defense, these quasi-sisters will have to work together to conceal the crime and preserve Evelyns scientific reputation. The Echo Wifes juicy premise runs deep, raising eerie questions about love, justice, and individuality.
49Snow Crash, by Neal Stephenson
Long before Facebooks Metaverse, Stephenson coined the term in this cyberpunk acid trip of a novel. Snow Crashs Hiro Protagonist lives a double life: in reality, he delivers pizzas for the Mafia, but in the Metaverse, hes a hacker and a warrior prince. When he learns about a lethal virus picking off hackers one by one, his race to find its dastardly architect sends him pinballing through everything from technological conspiracy to ancient Sumerian mythology. Sexy, action-packed, and downright prophetic in its vision of our virtual future, you'll want to strap in tight for this dizzying techno-thriller.
48Contact, by Carl Sagan
The great Carl Sagan wrote dozens of works of nonfiction, but just one novel: Contact, a 1985 bestseller that later became a Jodie Foster flick. Sagans preoccupations with intelligent life come into view through Dr. Ellie Arroway, a principled astronomer who detects and decrypts a deep-space transmission from a planetary system far, far away. At the transmissions urging, the nations of the world race to build a mysterious machine, but faith leaders call the enterprise (and the rationality of science) into question. Through this thoughtful, layered story, Sagan plumbs the often antagonistic relationship between science and religion, asking if perhaps both are seeking contact in different forms. After all, disciples from each camp can agree on one thing: The universe is a pretty big place. If it's just us, seems like an awful waste of space.
47A Canticle for Leibowitz, by Walter M. Miller Jr.
After World War III, Earth has fallen into a new Dark Age; most of the United States is a radioactive wasteland, and civilization is in tatters. While violent packs of survivors burn books and slaughter those who can read, the monks of St. Leibowitz preserve the heritage of the past by smuggling important volumes into their monastery. As the novel progresses throughout the centuries and a new Renaissance gives way to a second space age, so much about modern life changes, but at the monastery, much remains the same. Millers ambitious sci-fi classic captures the human tendency for self-destruction, as viewed through the cyclical rise and fall of civilization, but its not all doom, gloom, and nuclear warfareA Canticle for Leibowitz is a moving paean to the power of knowledge and hope.
46Solaris, by Stanislaw Lem
No one writes about intelligent life quite like Stanislaw Lem, who scoffed at little green men and instead put the alien in alien. In this dense and brainy novel, scientist Kris Kelvin lands on the planet Solaris to study the mysterious ocean enveloping its surface. Kelvin and his crew soon discover that this massive ocean is sentient: aloof, unknowable, and mysterious, it explores these explorers, reflecting their most painful memories back at them. What if aliens dont care to know us, and what if we cant possibly dream of understanding them anyway? Lem never tired of asking these questions, but of all his novels, Solaris makes our list for its perfect encapsulation of his singular vision.
45Neuromancer, by William Gibson
Cyberspace: a consensual hallucination experienced daily by billions of legitimate operators, in every nation. This is the setting of William Gibsons Neuromancersounds awfully familiar, doesnt it? The winner of Hugo, Nebula, and Philip K. Dick Awards, Neuromancer is often called the definitive novel of the cyberpunk genre (it went on to heavily influence the creators of The X-Files and The Matrix). Our hero is Case, an ex-cyber cowboy banished from cyberspace by his former employers. When a criminal syndicate comes knocking, promising to restore Cases uplink in exchange for his hacking services, the novel transforms into a kaleidoscopic espionage thriller. Trippy, surreal, and slick as hell, Neuromancer is a ride you wont soon forget.
44The Book of Phoenix, by Nnedi Okorafor
Science fiction and magical realism collide in this imaginative prequel to Okorafors World Fantasy Award-winning Who Fears Death. Here we meet Phoenix, an accelerated woman grown in New Yorks Tower 7. Though shes only two years old, she has the mind and body of a middle-aged adult, along with superhuman abilities. Phoenix suffers a painful awakening when her lover takes his life under dubious circumstances, proving that Tower 7 is less of a home and more of a prison. Her daring escape leads her to Ghana, where she learns brutal truths about colonialism, and vows to fight back against her oppressors. Blistering with love and rage, Phoenixs fight for justice is downright electrifying.
43A Clockwork Orange, by Anthony Burgess
In the many decades since its 1962 publication, A Clockwork Orange has become such a high school curriculum fixture that its easy to forget just how damn good it is. Burgess transgressive dystopia is the story of Alex, a teenage gangster who leads his fellow droogs in shocking acts of ultra-violenceuntil hes apprehended by the draconian police. In prison, Alex is subjected to a brutal reconditioning, leaving him a changed and diminished man. Told in high-flying, pyrotechnic patois thats since bled into the cultural lexicon, A Clockwork Orange is a postmodern triumph.
42The Hitchhiker's Guide to the Galaxy, by Douglas Adams
Few science fiction novels can claim to have inspired their own holiday, but The Hitchhikers Guide to the Galaxy isnt your ordinary science fiction novel (the holiday is Towel Day, if you must know). Adamss signature work has cast a long shadow over popular culture, and for good reason. This absurdist comedy is the story of Arthur Dent, a hapless everyman who wanders the universe after Earth is destroyed to make way for the galactic highway. As he romps through space with alien travel writer Ford Prefect and a crew of android oddballs, Dents adventures illuminate how utterly insignificant our little blue green planet truly is. In the face of absurdity, Adams reminds us, what else can we do but laugh?
41This Is How You Lose the Time War, by Amal El-Mohtar and Max Gladstone
Structured as a poetic correspondence between two time-traveling spies, this forbidden romance puts the distance in long-distance relationship. As Agents Red and Blue hopscotch through the multiverse, altering history on behalf of their respective military superpowers, they leave behind secret messages for one anotherfirst taunting, then flirtatious, then flowering with love and devotion. Theres a kind of time travel in letters, isnt there? Blue muses. Letters are structures, not events, Red replies. Yours give me a place to live inside. Amid the dangerous chaos of their circumstances, Red and Blue find constants in one another. Playful and imaginative, told with lyrical grace, this is a dazzling puzzle box of a novella.
40The Moon Is a Harsh Mistress, by Robert A. Heinlein
Though Heinlein is considered one of The Big Three science fiction writers (along with Isaac Asimov and Arthur C. Clarke), hes arguably the least well-known among casual sci-fi readers. If youre new here, start your Heinlein odyssey with his best novel, The Moon is a Harsh Mistress. In the year 2076, a penal colony on the moon rises up against the tyranny of Earth, declaring themselves the Free State of Luna, and themselves "the loonies." Its a parable for the American Revolution, but instead of tea dumped in the Boston harbor, weve got electromagnetic catapults hurling moon rocks at Earth with the force of atomic bombs. Fun fact: the phrase, There aint no such thing as a free lunch originated in this novel.
39A Wrinkle in Time, by Madeleine L'Engle
Who says science fiction is only for adults? LEngles enduring young adult classic is the story of tweenage siblings Meg and Charles Murray, who travel through the universe by way of a space-time-folding tesseract. In search of their missing father, Meg and Charles encounter galactic marvels of all kinds, from a utopian planet to the source of all evil in the universe. A Wrinkle in Time never makes the mistake of assuming that young readers cant handle all the brainy concepts and mature themes that science fiction has to offer. Though its an unforgettable read at any age, its perhaps best-loved by the generations of readers who remember it as their gateway to sci-fi.
38The Time Machine, by H.G. Wells
Published way back in 1895, The Time Machine was one small step for H.G. Wells, but one giant leap for science fiction. The novel popularized the concept of time travel by vehicle, lighting the way for everything from Back to the Future to Doctor Who. The Time Machine is the story of the Travelers journey 800,000 years into the future, where he discovers that mankind has evolved into two races: the ethereal Eloi and the predatory Morlocks. Through the Travelers exciting, nail-biting adventure, we see an entire generations fin-de-sicle anxieties about industrialization and the future of humanity. This short, seminal book is a must-read for any sci-fi fan.
37Rosewater, by Tade Thompson
Tade Thompsons award-winning Wormwood Trilogy opens in Nigeria circa 2066, where the town of Rosewater has formed around a mysterious alien biodome rumored to have extraordinary healing powers. Enter Kaaro, a government security officer known as a sensitiveessentially, a bioengineered race of psychics with access to an alien informational network called the xenosphere. When sensitives start dying off mysteriously, Kaaro embarks on a hardboiled detective mission, bringing the true nature of sensitives existence into the cold, hard light of day. A work of dazzling cyberpunk imagination and visionary Afrofuturism, Rosewater masterfully fuses a story of postcolonial trauma with a first contact narrative.
36The Stand, by Stephen King
Horror, fantasy, and science fiction converge in The Stand, a master storytellers doorstopper about the eternal struggle between good and evil. After a bioengineered influenza virus escapes from a government laboratory, mankind succumbs to the deadly pandemic in just weeks, leaving survivors scattered across the barren United States. Two communities coalesce around very different leaders: Mother Abagail, a benevolent holy woman seeking utopia, and Randall Flagg, the human personification of violence and chaos. As the communities fight to wipe one another out, King weaves an epic tale about theology, morality, and human nature. In the wake of our own pandemic, The Stand has only grown in resonance and prescience.
35The Children of Men, by PD James
Before it was a grim Alfonso Cuarn film, The Children of Men was a grim, remarkable novel. The year is 2021: with all men inexplicably sterile, no child has been born for 25 years, and the human race faces extinction. England is ruled by the Warden, a despotic leader who prizes the youngest generation above all others. Theo Faren, the Wardens estranged cousin, sleepwalks through life as an Oxford historian until he receives a visit from a group of dissidents, whose company includes a pregnant woman. Packed with prescient insight about politics, power, and tyranny, The Children of Men will rattle you for years to come.
34Radiance, by Catherynne M. Valente
When documentary filmmaker Severin Unck fails to return from her latest project on Venus, so begins a metafictional odyssey into her life, work, and disappearance. Constructed in patchwork fashion from scripts, depositions, and interviews with people who knew Unck, Radiance ushers us into Valentes pulpy alternate universe, where Hollywood is an interplanetary system with backlots on the moon, but cinema never progressed beyond silent black and white films, thanks to the Edison familys tight grip on the patent process. Hopscotching through this kaleidoscopic universe of beauty, adventure, and artistry, Valente tells a moving story about why we tell stories at all.
33Red Mars, by Kim Stanley Robinson
Plenty of writers have contemplated the colonization of Mars, but few have done it with such extraordinary granularity as Robinson, who dug in with gusto through his Mars Trilogy. Arthur C. Clarke himself called Red Mars the best novel on the colonization of Mars thats ever been written. The novel takes place in 2026, when colonists fleeing an overpopulated Earth touch down on the red planet. Carefully selected and trained, they set about the task of terraforming hostile, sandswept Mars, but establishing a viable settlement will demand everything they have to give. Robinson looks at planetary colonization through every conceivable lens: politics, biology, ecology, medicine, psychology, and morality, just to name a few. The result is speculative fiction that feels astoundingly real.
32The City & The City, by China Miville
That this novel won a constellation of awards spanning science fiction, fantasy, and weird fiction is proof of Mivilles gift for straddling genres. The City & The City is set in two fictional Eastern European cities occupying the same physical space; from birth, residents are trained to unsee the opposing city, under the threat of criminal penalties. When a murdered woman is found lying in the wastelands, Inspector Tyador Borl of the Extreme Crime Squad is called to the scene, but the crime defies logic: this woman was murdered in one city, and her body was dumped in the other. Borls investigation exposes startling secrets about this strange way of life, taking us on a noirish metaphysical journey through the doors of perception.
31Hyperion, by Dan Simmons
Inspired by Chaucers Canterbury Tales, Simmons Hyperion Cantos begins with this story of seven pilgrims sent on a potentially fatal mission to the Time Tombs of Hyperion. There, they hope to confront the Shrike, a cosmic being with the power to bend space and time. Throughout the journey, they share their stories of suffering under the Hegemony of Man, the intergalactic government that sold humanity out to a civilization of AIs. From aging in reverse to encounters with immortality, each story is a cerebral fable, rich in Lovecraftian terror, mythological import, and breathtaking worldbuilding.
30Dhalgren, by Samuel R. Delany
Philip K. Dick once called Dhalgren the worst trash Ive ever read, while William Gibson described Delany as the most remarkable prose stylist to have emerged from the culture of American science fiction. Read it yourself, and you can be the judge. This cult classic opens when a man without a name wanders into Bellona, a midwestern city razed by a space-time continuum-altering disaster. Strange phenomena abound: two moons burn in the night sky, time moves in loopy circles, and electronic signals cant reach the city, cutting it off from the outside world. To borrow a phrase from our narrator, Dhalgren has more to say than vocabulary and syntax can bear; written in a circular structure, its a novel with multiple entry points, which will test your patience and bend your brain. Dense and psychedelic, packed with transgressive ideas about race, sex, and gender, its a work of singular vision, but not for the faint of heart.
29The Long Way to a Small, Angry Planet, by Becky Chambers
The first volume in Chamberss Wayfarers series is pure, rip-roaring funa space opera with a big, gooey heart. Running from her mysterious past on Mars, Rosemary Harper joins the multi-species crew of the Wayfarer, a spaceship that creates wormholes to connect distant trade routes. En route to their biggest job yet at the edge of the Galactic Commons, the eclectic crew has ample time to bond, and bond they do. Plot takes a back seat for the majority of this character-driven narrative as Rosemary learns deeply humane truths about what makes us human (or, rather, what makes us alien): identity, sexuality, race, tradition. Chambers proves that spacefaring neednt be all about the destination. Sometimes, its about the journey.
28The Body Scout, by Lincoln Michel
In Michels cyberpunk New York of the future, climate change and repeated pandemics have ravaged the city; meanwhile, cybernetic body modification is de rigeur, and Neanderthals roam the earth again. In this dystopian milieu, we meet Kobo, a down-on-his-luck baseball scout who recruits genetically engineered talent for Big Pharma-owned teams. JJ Zunz, Kobos adopted brother, is the souped-up superstar of the Monsanto Metsbut when Zunz drops dead on the field, Kobo smells foul play. Kobos transformation into an amateur sleuth sends him pin-balling through a web of corporate espionage, making for a breathlessly paced techno-thriller characterized by stunning, spiky world building.
27Zone One, by Colson Whitehead
After a zombie pandemic decimates American life, separating humanity into the living and the living dead, who cleans up the wreckage? In Zone One, we meet the janitors of the undead: sweepers like Mark Spitz, who are tasked with taking out zombie stragglers to prepare Manhattan for resettlement. Inspired by the horror fiction of Stephen King and the science fiction of Isaac Asimov, Whiteheads foray into zombieland delivers gallows humor and nightmarish gore in spades; at the same time, this post-apocalyptic elegy for the modern world elevates the genre to new heights.
261Q84, by Haruki Murakami
This epic descendent of George Orwells 1984 covers that fateful year in two storylinesone fictional, one real. Bridging that gap are two long-lost lovers: Aomame, an assassin targeting domestic abusers, and Tengo, an aspiring novelist ghostwriting a dyslexic teenagers bestseller. When Aomame discovers that the world is not what it seems and works to take down a dangerous cult leader, she and Tengo are drawn into a distorted reality, searching for one another across the chasm. Its often said that a novel should contain the world; in 1Q84, Murakami makes good on that promise, weaving everything from recipes to music into this mammoth tale of love and longing in a contemporary Tokyo lit by two moons.
25Future Home of the Living God, by Louise Erdich
In this chilling dystopian triumph, an American master warns against a world gone mad. When evolution runs in reverse, leading to babies born with primitive traits, government squads begin imprisoning pregnant women; meanwhile, religious extremists plot to take control of the nation. Enter twenty-something Cedar Hawk Songmaker, four months pregnant at exactly the wrong time, whose search for her Ojibwe birth parents leads her into the maw of danger. Like The Handmaids Tale before it, Future Home of the Living Gods nightmarish vision of theocracy and reproductive dystopia rings all too true.
24Ammonite, by Nicola Griffith
When anthropologist Marghe Taishan touches down on the mysterious planet Jeep, she soon finds that shes in over her head. Centuries ago, Earth colonized the planet; then, a fatal virus wiped out all the men, and contact with the remaining colonists was lost. Generations of radio silence later, Marghe arrives to test a promising vaccine while a greedy corporation waits in orbit, hoping to ransack the unspoiled planet. As Marghes stay progresses, she becomes fascinated by Jeeps powerful women, and ever more enmeshed in its tribal mythologies and conflicts. When Marghe endangers her life to unravel the biological mystery of how Jeeps inhabitants procreate, Ammonite asks: when does a human become an alien? Gripping and gutsy, rich in layers of feminist and queer thought, Ammonite gleefully throws a stick of dynamite into the sci-fi firmament.
23Oryx and Crake, by Margaret Atwood
Last man on Earth narratives are rarely as taut and morally provocative as Oryx and Crake, the first volume in Atwoods dystopian MaddAddam trilogy. Our protagonist is Snowman, the lone survivor of a plague that destroyed mankind. Now living among the Crakers, a bioengineered race of childlike humanoids, Snowman mythologizes their origin story, with some creative embellishments. The tale takes him back to the Before Times, when life was a corporatocracy characterized by genetic engineering and consumer culture. Oryx and Crake isnt for the faint of heart (here there be child pornography, ritualized killings, and animal abuse) but if you can stomach it, reading this prescient novel is like looking in a funhouse mirror of our own failings.
22The Resisters, by Gish Jen
Welcome to AutoAmerica, where AIs have put many people out of work, the privileged Netted live on high ground, and the rest of the population, known as Surplus, live in swamplands wracked by consumerism. Teenage Gwen plays baseball with fellow members of the Surplus in an underground league, but when the government takes notice of her talents, shes shipped off to the Olympics in ChinRussia, playing in dangerous territory alongside the Netted. Like Brave New World before it, The Resisters explores our consent in our own subjugation. "No one would have chosen the extinction of frogs and of polar bears and yet it was something we humans did finally choose," Jen writes. In this funny and tender novel, she makes the impossible look easy, grafting a heartfelt story about family onto big questions about freedom and resistance.
21Shikasta, by Doris Lessing
Though it was likely Doris Lessings long and varied career that netted her the Nobel Prize for Literature, we like to think that her ambitious excursion into science fiction, via her Canopus in Argos: Archives series, also had something to do with it. The first installment, Re: Colonised Planet 5, Shikasta, is a visionary work of imagination. Compiled from ephemera like documents, letters, and journal entries, the novel is structured as a history book for residents of the planet Canopus, who long ago colonized a little blue marble they call Shikasta. Shikasta is clearly the planet Earth, shaped from Genesis to World War III by the Canopians and their colonial rivals. Lessings perspective on history is downright cosmic in scope, but occasionally cheeky, too. (When Earthpeople complain that their heavenly leaders have abandoned them, the Canopians retort, "We've regularly sent people to guide and comfort them! Well, except for a brief period during the last fifteen hundred years.") Lessings ambitious vision of human lifeand human follyoffers alternate history on an eschatological scale.
20An Unkindness of Ghosts, by Rivers Solomon
Solomons intricate and imaginative debut novel takes place on the HSS Matilda, a generation ship carrying survivors of a destroyed Earth toward a new star system. Throughout the generations, life on the ship has become harshly segregated, with people of color confined to a grueling routine of hard labor on the lower decks. Here, we meet Aster, a brilliant and rebellious healer whose search for answers about her mothers suicide stands to galvanize a shipwide uprising. Peopled with a rich array of queer and neurodiverse characters, An Unkindness of Ghosts makes dazzling use of science fictions trappings to tell a gutting story about slavery and intergenerational trauma.
19Annihilation, by Jeff VanderMeer
In this spectacular blend of science fiction and climate fiction, VanderMeer sets his sights on Area X, a lush and remote landscape that has turned against humankind, producing brain-bending effects on scientists who venture into the territory to investigate. As the secrets of Area X reveal themselves not just to the scientists, but to the disorganized agency that monitors these expeditions, the bureaucratic and ecological consequences pile upward. Dreadful, Lovecraftian, and downright existential, Annihilation is a dizzying descent into a metaphysical wilderness leagues away from our lived reality.
18The Sirens of Titan, by Kurt Vonnegut
Perhaps you expected to see Slaughterhouse Five on this list instead, but bear with us. The Sirens of Titans takes Slaughterhouses science fiction slant and leans into it full throttle, making for something even more spectacular, strange, and side-splittingly funny. In The Sirens of Titan, Malachi Constant, the richest man on a future Earth, hopscotches across the solar system, suffering the slings and arrows of fortune at every turn. Constant has come into the crosshairs of Winston Niles Rumfoord, a malevolent space traveler whos become chrono-synclastic infundibulated by his voyage. Now, like a vindictive god, Rumfoord is determined to teach the entire human race a lesson by pitting them against the belligerent Martians. Pulpy and surprisingly poignant, The Sirens of Titan trafficks gracefully in some of sci-fis most enduring questions about fate, free will, and predestination.
17Childhood's End, by Arthur C. Clarke
Sci-fi godfather Arthur C. Clarke wrote dozens of acclaimed novels, including 2001: A Space Odyssey and Rendezvous With Rama, but he considered Childhoods End to be one of his favorite works. Who are we to disagree with him? In this formidable novel, the space race grinds to a halt when vast alien spaceships appear over Earths major cities. The Overlords (or, as they prefer to be known, The Guardians) have arrived on what seems like a mission of peace, determined to end war, ignorance, disease, and poverty. A new golden age begins, but utopia has a price: creativity stagnates, science loses forward momentum, and the human race, by and large, is stifled. As the Overlords secret motives come into view, Clarke reflects on the messy striving that makes us human. (Nominated for a Hugo Award in 1954, Childhoods End ultimately lost to Fahrenheit 451, but the novel remains timeless.)
16The Complete Robot, by Isaac Asimov
Asimovs landmark Foundation series could easily have landed on this listawarded the one-time Hugo Award for Best All-Time Series in 1966, its certainly made a mark on science fiction. But Asimov was at his best, both as a fiction writer and a conceptual thinker, when he wrote about robots, those rascally bags of bolts. The Complete Robot contains 37 of those stories, including the famous I, Robot. Here, Asimov laid down the highly influential Three Laws of Robotics, which would go on to shape both a genre and a field of study. From hostile to heroic to everything in between, the robots in these stories evolved as Asimovs vision did. The world hasn't been the same since.
15How to Live Safely in a Science Fictional Universe, by Charles Yu
National Book Award winner and Westworld writer Charles Yu is one of todays most exciting speculative fiction talents. His metafictional debut centers on Charles Yu, a lonesome time machine mechanic for Time Warner Time, which turns a profit by operating alternate universes. Charles oversees Minor Universe 31, a science fiction phantasmagoria where he encounters Linus Skywalker (who offed his famous father), but all the while, hes deep in mourning for his own father, a time travel pioneer who vanished. When Charles shoots his future self in a kneejerk moment of panic, he's soon stuck in a time loop that may see him colliding with his long-lost parent. Trippy and clever, playful and full of heart, this bittersweet novel speaks volumes about our all-too human desire to change the past.
14Brave New World, by Aldous Huxley
Aldous Huxley wrote dozens of far-out books, but Brave New World rises above the pack for a reason. In this nightmarish vision of the future, Huxley imagines a world of mood-flattening pharmaceuticals, information overload, and on-demand sex. The masses are mollified by this endless cycle of consumption, allowing the totalitarian World State to rule unchallenged, but sleep scientist Bernard Marx is unsatisfied by life without passion or pain. When he dares to fight back against the World Controllers, Brave New World veers headlong into a thrilling story about nonconformity and individuality that still rattles us today. In 2002, the novelist JG Ballard said it best: 1984 has never really arrived, but Brave New World is around us everywhere.
13The Employees, by Olga Ravn
The Employees accomplishes more in 136 pages than some sci-fi novels do in 500. On a ship hurtling through deep space, humans and humanoids work together under a rigid corporate hierarchy. When they land on New Discovery, crew members retrieve mysterious objects that exert a strange power over man and machine alike, awakening dreams, memories, and longing. Humans mourn their lost connections on Earth, while their humanoid colleagues yearn for connections theyve never known. Constructed as a series of witness statements from the crew, gathered after tensions with their oppressive employer boil over, The Employees is an unforgettable novel about the psychic costs of labor under capitalism. Yet it also reaches deeper to explore science fiction's animating questions: What makes us human? Which of us is more human, person or robot? Is a synthetic life still a life? Dreamlike and sensual, The Employees shouldn't be missed.
121984, by George Orwell
In a world where concerns about privacy, government overreach, and freedom of information are more relevant than ever, 1984 continues to frighten and astound. Published in 1949, Orwells masterpiece is the chilling story of a rebellious Ministry of Truth bureaucrat; through his eyes, we glimpse a terrifying, tyrannical society, where independent thought is a crime and truth is a fiction. All these decades later, 1984 still looms large in our cultural imagination, from its perch in our curriculum to its pervasive influence on our language. Its difficult to imagine any science fiction novel with more influence.
11The Three-Body Problem, by Cixin Liu
One of Chinas most acclaimed science fiction writers opens his Hugo Award-winning Remembrance of Earths Past trilogy with The Three-Body Problem, a gripping first contact thriller set against the backdrop of Chinas Cultural Revolution. When a young physicist comes to work at the governments secretive Red Coast Base, she soon learns that frontier scientists are communicating with extraterrestrialsand theyre planning to make a hostile visit. Enormous in scope, rich in both twisty-turny mysteries and big ideas about progress, The Three Body-Problem marks the ascension of a writer bound to become every bit as canonical as Arthur C. Clarke or Isaac Asimov. This series will soon become a Netflix series from Game of Thrones showrunners David Benioff and D.B. Weiss, so get in on the ground floor while you still can.
10Do Androids Dream of Electric Sheep?, by Philip K. Dick
Do Androids Dream of Electric Sheep? famously became the basis for Blade Runner, but if youre a movie fan who hasnt read the novel, youre in for something new, as its more of a complement than a faithful adaptation. Some of the familiar bones are here, like bounty hunter Rick Deckard and his mission to retire rogue androids, but you wont find the term blade runner anywhere. Set in an abandoned San Francisco after World War Terminus radioactive fallout has destroyed the earth, this short gut-punch of a novel finds its central theme in empathy. Can androids experience it? Are humans who lack it any better than machines? Do Androids Dream of Electric Sheep? asks more questions than it answers, reveling in ambiguity about just what separates man from machine. Like all the best science fiction, its weighty foray into what makes us human will linger with you for a long time.
9Station Eleven, by Emily St. John Mandel
Set before, during, and after the lethal Georgian Flu snuffs out 99% of the worlds population, taking the familiar contours of human civilization along with it, Station Eleven is the incandescent tale of the Traveling Symphony, a nomadic troupe of actors and musicians who perform Shakespeare for the scattered settlements of the Great Lakes region. Along the road, they encounter a violent cult leader known only as the Prophet, who preaches that the virus was an act of Goda divine cleansing of the unworthy. Where so many post-apocalyptic novels traffic in the forces that divide us, Station Eleven celebrates that which allows us not just to survive, but to live: making art, belonging to something bigger than ourselves, searching tirelessly for what it means to be human. Haunting and lovely, Station Eleven is at once an elegy for a lost world and a paean to the human spirit.
8Exhalation, by Ted Chiang
In this stellar collection of short stories, one of the most award-winning science fiction writers of our time tees up nine brilliant tales of time travel, artificial intelligence, and alternate universes. The collection opens with a Hugo Award-winning parable set in ancient Baghdad, where a merchant traveling through an alchemists portal learns a familiar lesson about the impossibility of erasing the past. In another standout, a software tester spends an emotional two decades raising an artificial intelligence as if it were a digital pet (Tamagotchi users, take note). The remarkable title story, structured as a journal entry by a mechanical scientist dissecting his own brain, offers profound wisdom about consciousness: Contemplate the marvel that is existence, and rejoice that you are able to do so. Through lean, thought-provoking prose, Chiang renders stories about man and machines deeply feltand deeply human.
7Never Let Me Go, by Kazuo Ishiguro
One cant say too much about Never Let Me Go without spoiling the novels gut-wrenching twist. But heres what we can reveal: in Ishiguros chilling magnum opus, we meet three students of Hailsham, a quixotic English boarding school where sheltered children are educated in the arts and taught nothing of the outside world. Only when they become adults do they learn the shocking truth about Hailshams nefarious activities, and the reality of their terrible purpose. At once an arresting mystery, a Gothic romance, and a tear-jerking work of science fiction, Never Let Me Go is a masterpiece of tension and tone, as well as a powerful indictment of a future shaped by science without ethics.
6The Left Hand of Darkness, by Ursula K. Le Guin
In 1969, Le Guin put feminist science fiction on the map with The Left Hand of Darkness. According to The Paris Review, "No single work did more to upend the genre's conventions. This barrier-breaking first contact narrative opens on the planet Gethen, where Earth-born emissary Genly Ai is dispatched to broker an interplanetary alliance. The ambisexual Gethenians live without gender binaries, meaning that theyve developed a world without war, where children are raised communally. Ais inability to think beyond his own misogyny and homophobia threatens his mission, imperils his life, and endangers his growing connection with Estraven, Gethens disgraced prime minister. In this visionary work of radical imagination, Le Guin explores a world beyond the constraints of gender and sex, and takes us to the heights of love without limitations.
5Kindred, by Octavia Butler
Octavia Butlers contributions to science fiction and Afrofuturism are legendary, meaning that selecting just one of her works for this list was a tall order. But Kindred, perhaps her best-known novel, stood out above the rest as a master class in the ability of science fiction to speak to the contemporary moment. This is the story of Dana, a Black woman in Los Angeles circa 1976, who finds herself violently transported back in time to the antebellum plantation where her ancestors were enslaved. Each time she pinballs through past and present, Danas stays at the plantation become longer and more dangerous, forcing her to confront the gruesome legacies of slavery, misogynoir, and white supremacy. As Harlan Ellison once said, Octavia Butler is a writer who will be with us for a long, long time, and Kindred is that rare magical artifact the novel one returns to, again and again. Almost like time travel, we keep coming back to it.
4The Fifth Season, by N.K. Jemisin
Like many science fiction writers, its impossible to categorize Jemisin in just one genre. Many of her works belong to the hybrid genre of science fantasy, including this paradigm-shifting first installment in her Hugo Award-winning Broken Earth trilogy. The Fifth Season introduces a characteristically Jemisinian feat of astonishing worldbuilding: the Stillness, a dangerous continent wracked with volcanoes, earthquakes, and tectonic chaos. There live the orogenes, who have the power to manipulate the elements, but face persecution and lynching. Through the linked narratives of three extraordinary women, Jemisin depicts the tragedy of an orogenes life with brutal, unsparing detail. As these unforgettable characters seek safety and agency, Jemisin weaves a shattering story about systemic oppression, where gritty glimmers of hope shine through the bleak edges.
3The Martian Chronicles, by Ray Bradbury
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The 50 Best Sci-Fi Books of All Time - Esquire
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Why Would an Alien Civilization Send Out Von Neumann Probes? Lots of Reasons, says a new Study – Universe Today
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In 1948-49, mathematician, physicist, computer scientist, and engineer John von Neumann introduced the world to his idea of Universal Assemblers, a species of self-replicating robots. Von Neumanns ideas and notes were later compiled in a book titled Theory of self-reproducing automata, published in 1966 (after his death). In time, this theory would have implications for the Search for Extraterrestrial Intelligence (SETI), with theorists stating that advanced intelligence must have deployed such probes already.
The reasons and technical challenges of taking the self-replicating probe route are explored in a recent paper by Gregory L. Matloff, an associate professor at the New York City College of Technology (NYCCT). In addition to exploring why an advanced species would opt to explore the galaxy using Von Neumann probes (which could include us someday), he explored possible methods for interstellar travel, strategies for exploration, and where these probes might be found.
His paper, Von Neumann probes: rational propulsion interstellar transfer timing, was recently published in the International Journal of Astrobiology, a Cambridge University publication. In addition to being an Adjunct and Emeritus professor of physics at NYCCT, Matloff is a Fellow of the British interplanetary Society (BIS), a Member of the International Academy of Astronautics (IAA), and has been a consultant for the NASA Marshall Space Flight Center.
His pioneering research in solar-sail technology has been utilized by NASA to develop concepts for interstellar probes and diverting potentially-hazardous objects (PHOs) in other words, asteroids. His writings have helped establish interstellar-propulsion studies as a sub-division of applied physics in academia. He also co-authored books with fellow luminaries like MIT science-writer Dr. Eugene Mallove, noted physicist, author, and NASA technologist Les Johnson, and Italian researcher Dr. Giovanni Vulpetti.
In April 2016, Matloff was appointed an advisor to Yuri Milners Breakthrough Starshot alongside fellow astrophysicists like Prof. Abraham Loeb (Harvard Smithsonian Center for Astrophysics) and Dr. Philip Lubin leader of the Experimental Cosmology Group at UC Santa Barbara. In January 2017, he presented a Frontiers Lecture on interstellar travel at the American Museum of Natural History in Manhattan, where he is also a Hayden Associate.
It is essential to address questions about Von Neumann probes, considering their implications for SETI and the Fermi Paradox. For decades, theoretical physicists and researchers have used the possible existence of Von Neumann probes to constrain the search for intelligence beyond Earth. As Matloff told Universe Today via Zoom, the road that brought us to this point was long and winding and went beyond any single person.
As he explained, the connection between Von Neumanns idea of Universal Assemblers and space exploration emerged sometime in the 1970s. This was largely due to interstellar studies like Project Daedalus, a fusion rocket concept developed by the British Interplanetary Society (BIS) between 1973 and 1977. Amid the debate over whether or such missions should be crewed or robotic, the idea of the Von Neumann probe was revived and applied.
In no time at all, the old SETI saw came up, where humanitys ability to conceive an idea is seen as a possible indication that an older, more advanced species might have done it already! As Michael Hart and Frank Tipler noted in their respective studies, the fact that we see no evidence for extraterrestrial interstellar probes is the most compelling evidence that humanity is alone in the Universe. This is the basis of the Hart-Tipler Conjecture, the earliest-known proposed resolution to Fermis Paradox.
According to Tipler, if ETIs did exist, they would have developed the capacity for interstellar travel and explored the Milky Way within ~300 million years:
What one needs is a self-reproducing universal constructor, which is a machine capable of making any device, given the construction materials and a construction program In particular, it is capable of making a copy of itself. Von Neumann has shown that such a machine is theoretically possible As the copies of the space probe were made, they would be launched at the stars nearest the target star. When these probes reached these stars, the process would be repeated, and so on until the probes had covered all the stars of the Galaxy.
Famed astronomer and science communicator Carl Sagan rebutted their conclusions a few years later in an essay titled The Solipsist Approach to Extraterrestrial Intelligence. In this famous paper (nicknamed Sagans Response), he and co-author William Newman declared that while there was an apparent absence of probes and other technological marvels, this was by no means conclusive. As they poetically summarized: the absence of evidence is not the evidence of absence.
Matloff similarly takes the Hart-Tipler conjecture to task in his paper for its simplistic and presumptuous nature. As he explained to Universe Today via email:
The Solar System is huge and mostly unexplored, and the probes could be very small. There could be probes everywhere: in craters on the Moon, or lurkers in the Asteroid Belt and Kuiper Belt. There are 100 million objects in the Kuiper Belt alone and we have examined only two, one of which was very anomalous in its shape.
The object he refers to is MU69 (aka. Arrokoth), a contact binary that New Horizons studied during its historic flyby onJanuary 1st, 2019. As the images acquired showed, the object appeared to be two icy bodies that pancake-like in shape (rounded by flattened) and connected by a neck. This strange appearance led New Horizons Principal Investigator Alan Stern to nickname the object Snowman.
In short, humanity has barely scratched the surface when it comes to cosmic exploration, including our backyard. For all we know, there could be countless probes lurking in our Solar System actively watching us, or which became inoperable long ago and have since settled into orbit around the Sun. The only way to resolve questions related to Von Neumann probes (and the Fermi Paradox) is to refine our search methods and keep searching!
As we addressed in a previous article, traveling through interstellar space is incredibly time-consuming! Using conventional technology, it would take anywhere from 19,000 to 81,000 years to reach even the nearest star system (Alpha Centauri). This includes chemical propellants, Hall-effect thrusters (ion engines), gravity assists, and solar sails. Hence, more advanced propulsion methods need to be considered when addressing interstellar travel.
Many concepts are currently being investigated by researchers here on Earth. These include nuclear-thermal and nuclear-electric propulsion (NTP/NEP), fusion propulsion, photon and electric sails, matter/antimatter annihilation, and even some truly exotic concepts (like the Alcubierre Warp Drive). In keeping with the idea that humanity is a recent arrival to the Universe, SETI researchers assume that more advanced civilizations are likely to have researched these concepts already.
First, Matloff considers unpowered gravity assists, where spacecraft use the gravitational force of giant planets to achieve higher velocities. To date, five space probes have been launched from Earth that used a gravity-assist maneuver to achieve escape velocity from the Solar System. These include the Pioneer 10/11, the Voyager 1/2, and the New Horizons mission. The fastest of these missions (Voyager 1) will reach the Alpha Centauri star system in about 70,000 years based on its current velocity.
Powered gravity assists, otherwise known as an Oberth Maneuver, consist of a spacecraft making a powered maneuver while deep within a massive planets gravity well. According to Matloff, such a maneuver could allow a spacecraft to achieve twice the velocity of the Voyager 1 mission (41 km/s; 25.5 mi/s) and make the journey to Alpha Centauri in roughly 30,570 years.
When adjusted for nuclear fission and fusions concepts (using NASA research as a template), Matloff concludes that a nuclear-electric spacecraft could traverse one light in 1500 years while a fusion spacecraft could do the same in 3000 years. That works out to a one-way transit time of 6,550 and 13,100 years to Alpha Centauri, respectively.
Based on several factors, like sail material and whether the probe is nano-miniaturized, Matloff estimates that photon and electric sails could achieve relativistic speeds (a fraction of the speed of light) and make the transit in 1000 years. This is considerably longer than the Breakthrough Starshot concept, which calls for velocities of 0.2 c and a transit time of just 20 years. However, this is based on an estimated velocity of 300 km/s (186 mi/s) and not Starshots ambitious goal of 60,000 km/s (37,280 mi/s).
Matloffs study provides no estimates for antimatter propulsion because the technology is simply not feasible yet. According to a report prepared by NASA scientist Robert Frisbee for the 39th AIAA/ASME/SAE/ASEE Joint Propulsion Conference and Exhibit (2003), a two-stage rocket could make it to Alpha Centauri in about 40 years. However, Frisbee indicated that the spacecraft would need over 815,000 metric tons (900,000 US tons) of fuel.
No FTL concepts are considered for precisely the same reason (i.e., the technology is not verifiable and may never be). Meanwhile, the estimate for photon probes is based on several factors, predominantly the types of materials used for the sail. Said Matloff:
Conservative values for sails were assumed. For instance, the industrial infrastructure necessary to produce a slower aluminum sail is a lot simpler than the infrastructure required to produce a faster graphene sail. A graphene sail could do this in ~1,000 years at an interstellar cruise velocity in excess of 1,000 km/s. My estimate of multi-millennia travel by solar photon sails at ~300 km/s is for the much more conservative aluminum sail. Less industrial infrastructure would be necessary for Al than for graphene.
In terms of rationale, Matloff explores many possibilities as to why a civilization would launch a fleet of Von Neumann probes. In this section, many of the arguments put forth by theorists who have explored questions related to alien probes. These include the Hart-Tipler Conjecture, the Berserker Hypothesis, and other research that attempted to place constraints on their reproduction and expansion rates.
Among the more popular rationales that have been explored include life after death, where an advanced civilization facing imminent demise would send out probes to broadcast messages. These could include stories of their accomplishments (look upon our works and be impressed!), instructions on how to avoid the same fate (its not too late!), or just advertisements of their existence (This is who we were. Remember us!).
There is also the possibility that probes would take the form of benign lurkers watching planet Earth from a distance. These probes could have been dispatched from a nearby star system as it made a close pass to our Solar System (Benford, 2021a, 2021b). A variant on this, malignant lurkers, suggests that extraterrestrials might dispatch armed probes (aka. berserker probes) to investigate Earth as a potential threat and destroy it.
It has also been ventured that some of these probes could still be here likely on the Moon, Earth Trojans, and Earth co-orbital objects and would make viable targets in the Search for Extraterrestrial Artifacts (SETA). Examples include recent studies by Jim Benford, Prof. Abraham Loeb, Konstantin Batygin, and the Initiative for Interstellar Studies (i4is) that show how interstellar objects (ISOs) like Oumuamua and 2I/Borisov regularly enter our Solar System and are periodically captured.
Related research has also shown that the study of the captured ISOs (and new arrivals) will be possible in the near future thanks to the Vera C. Rubin Observatory and initiatives like Breakthrough Listen and the Galileo Project. Another rationale is directed panspermia, where an advanced civilization may choose to forgo sending crewed ships to distant stars (which could take thousands of years) and instead send spacecraft equipped with gene banks or fertilized ova.
Matloff cites Tiplers 1994 book, The Physics of Immortality, where he elaborated on how humans could achieve interstellar colonization with probes someday. As Matloff summarizes it, A Von Neumann probe could carry fertilized human ova to be raised robotically and populate in-space habitats circling nearby stars that would be constructed by the probe. A more advanced civilization might replace embryos with computer uploads of human essences.'
In recent years, a similar idea has been proposed by Claudius Gros, a researcher with Goethe Universitys Institute for Theoretical Physics and the founder of the Project Genesis. The purpose of Genesis is to send spacecraft with gene factories or cryogenic pods to transiently-habitable planets that orbit M-type (red dwarf) stars. This refers to rocky planets with atmospheres rich in abiotic oxygen (not produced biologically) that would be uninhabited but still capable of supporting life.
By seeding these worlds with basic life, entire biomes could develop in places where life would not otherwise arise. If life turns out to be a very rare phenomenon in the Universe, a space-faring civilization might deploy Von Neumann probes with a much happier purpose, writes Matloff. Simply lifeforms might be planted within oceans on sterile, water-bearing worlds to spread life through the Universe.
A final possibility Matloff considers has been explored extensively in science fiction: could advanced ETIs be sending out probes to direct galactic or universal evolution? A popular version of this scenario known as paleocontact argues that advanced life may have visited Earth in the past and deliberately directed humanitys cultural (or even physical) evolution (2001: A Space Odyssey, Prometheus, Stargate, etc.).
While some versions of this argument are pure pseudoarchaeology (i.e., aliens built the pyramids), Carl Sagan argued the paleocontact is something that scientists should not dismiss. As he and Iosif Shklovsky stated in their seminal book, Intelligent Life in the Universe, evidence of this contact may be preserved in the oral traditions of ancient cultures. As examples, they cite Romanian folklore and the Tlingit story of their encounter with the La Perouse expedition in 1786.
While these scenarios are all plausible in their own way, all of them have implications as far as SETI research is concerned which Matloff addresses in the final section of his study.
In the end, Matloff concludes that human astronomers may feel compelled to focus on Sun-like stars when looking for evidence of Von Neumann probes. This is perhaps the result of a Sol-centric bias, where we assume that G-type (yellow dwarf) stars are most likely to support habitable planets because thats what we are familiar with. The implications of this could be that advanced ETIs suffer from the same bias and prefer to send their probes to stars similar to their own.
However, recent exoplanets studies have demonstrated that M-type (red dwarf) stars are very good candidates for finding find Earth-like (aka. rocky) exoplanets that orbit within the Habitable Zone (HZ). In particular, Matloff stresses how recent research has shown that these planets could be potentially-habitable. If an advanced ETI is anything like us (evolved on a rocky planet), they are not likely to overlook these star systems.
If the spacing is less with M-type stars, you have [orbital] resonances, where a planet wouldnt be tidally-locked because other planets cause perturbations in its orbit. Even if they are tidally locked, that doesnt rule out the possibility of life. Von Neumann probes wouldnt rule them out. [Future surveys should] look for probes and life at all stable and mature F, G, K, M main-sequence stars. M stars in particular seem to have lots of planets in or near the habitable zone.
In addition to searching based on stellar classifications, Matloff also considers various proposals for where probes could be found in our Solar System. This once again raises the issue of proposed resolutions to the Fermi Paradox and their possible implications for SETI:
Unless humanity is the first space-faring civilization or we are under some form of quarantine [a la the Planetarium and Zoo Hypotheses], it is reasonable to wonder where such probes might be found in the Solar System. Due to dynamic geophysical and meteorological processes, space might be a better place to search than Earths surface.
Possible locations include the Moon, Earth Trojan asteroids, and Earth co-orbital asteroids. However, as Matloff himself previously suggested, searches for ET will have a better chance of success in the outer Solar System. One possible (rather large) location is the Kuiper Belt:
An advantage of the Kuiper Belt for the construction of a subsequent generation of Von Neumann probes is the availability of resources including volatile materials, he said, adding: if they wish to keep their activities hidden, an outer Solar System location for a probe or a probe base makes the most sense. I think the Kuiper Belt is the best place to start looking.
One of the hardest parts of SETI is the limited frame of reference we have. We know of only one planet that supports life (Earth) and one technologically-advanced civilization (ourselves). As such, all of our efforts fall under the heading of the low-hanging fruit approach, where we are confined to looking for signs of life (aka. biosignatures) as we know it and evidence of technological activity (aka. technosignatures) that we are familiar with.
So when it comes to getting inside the minds of ETIs, we are forced to stick to what we know (and what we might do in their place) and use the conclusions we come up with to help refine the search. While somewhat limiting, this approach does have many upsides. We have to assume that ETIs will be bound by the same physics we are since we know the laws dont change from one place and time to another.
We are also pretty confident that if intelligent life exists elsewhere in our Universe, evolution will favor certain similar characteristics like curiosity. While nothing definitive can be said about alien physiology, psychology, communications, or technology, its a safe assumption that they would be equally motivated to explore. Besides the allure of learning more about the cosmos and seeing whats out there, they would surely be interested in whether there are intelligent species other than themselves.
In that respect, theoretical studies like this one help us refine the search by subjecting Fermis famous questions (Where Is Everybody?) to serious scrutiny. By asking the questions, what would work best? and why would we do it? we select places and signals that we can look for. Beyond that, the only thing we can do is to keep looking until we see whats out there!
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Study Uncovers Functional Role of Genes Associated With Autism – Technology Networks
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About 1 in 44 children in the U.S. are diagnosed with autism spectrum disorder (ASD) by the age of 8, according to the 2018Centers for Disease Control and Prevention surveillance. How a childs DNA contributes to the development of ASD has been more of a mystery. Recently, clinicians and scientists have looked more closely at new, or de novo, DNA changes, meaning they only are present in affected individuals but not in the parents. Researchers have seen that these changes could be responsible for about 30% of ASD. However, which de novo variants play a role in causing ASD remains unknown.
Researchers at Baylor College of Medicine and Texas Childrens Hospital have taken a new approach to looking at de novo ASD genetic variants. In this multi-institutional study published in the journalCell Reports, they applied sophisticated genetic strategies in laboratory fruit flies to determine the functional consequences of de novo variants identified in theSimons Simplex Collection (SSC), which includes approximately 2,600 families affected by autism spectrum disorder. Surprisingly, their work also allowed them to uncover a new form of rare disease due to a gene called GLRA2.
ASDs include complex neurodevelopmental conditions with impairments in social interaction, communication and restricted interests or repetitive behaviors. In the current study, we initiated our work based on information from a cohort of ASD patients in the SSC whose genomes and those of their families had been sequenced, said co-corresponding authorDr. Shinya Yamamoto, assistant professor ofmolecular and human geneticsandofneuroscienceat Baylor and investigator at theJan and Dan Duncan Neurological Research Instituteat Texas Childrens. Our first goal was to identify gene variants associated with ASD that had a detrimental effect.
The team worked with thefruit fly lab modelto determine the biological consequences of the ASDassociated variants. They selected 79 ASD variants in 74 genes identified in the SSC and studied the effect of each ASDlinked gene variant compared to the commonly found gene sequence (reference) as a control, from three different perspectives.
Co-first author,Dr. Paul Marcogliese,postdoctoral fellow in Dr. Hugo Bellens lab, coordinated the effort on knocking out the corresponding fly gene, and examining their biological functions and expression patterns within the nervous system. They then replaced the fly gene with the human gene variant identified in patients, or the reference sequence, and determined how it affected biological functions in the flies.
Working with fruit flies carrying either the reference human gene or the variant forms, co-first authorDr. Jonathan Andrews, postdoctoral fellow inDr. Michael Wanglers lab at Baylor, was the point person investigating how these gene variants affected fly behavior. As ASD patients exhibit patterns of repetitive behavior as well as changes in social interaction, he evaluated the effect of the patient variants on an array of social and non-social fly behaviors, such as courtship and grooming. Its interesting to see that manipulation of many of these genes also can cause behavioral changes in the flies, Andrews said. We found a number of human genes with ASD variants that altered behavior when expressed in flies, providing functional evidence that these have functional consequences.
The third approach involved overexpressing the genes of interest in different tissue types in fruit flies. Co-first authorsSamantha Dealand Michael Harnish, two graduate students in Baylors Graduate Programs inDevelopmental BiologyandGenetics and Genomics, respectively, working in Dr. Yamamotos lab, headed these studies. While some gene variants may lead to conditions because they produce defective proteins, others may lead to disease because they cause overabundance or aberrant function of a particular protein, which can disrupt biological processes. We investigated whether overexpressing gene variants found in individuals with ASD might explain the detrimental effect for some of these genes, Deal said.
Altogether, the team generated more than 300 fly strains in which they conducted functional studies of human gene variants associated with ASD. Their screen elucidated 30 ASD-linked variants with functional differences compared to the reference gene, which was about 40% of the genes for which they were able to perform a comparative functional assay.
Some of the variants we studied had functional consequences that were moderately or clearly predicted to be disruptive, but other variants were a surprise. Even the state-of-the-art computational programs couldnt predict they would have detrimental effects, said Yamamoto. This highlights the value of using multiple, complementary approaches to evaluate the functional consequences of genetic variants associated with ASD or other conditions in a living animal. Our fruit fly approach is a valuable tool to investigate the biological relevance of gene variants associated with disease.
In addition, the wealth of data generated by the researchers revealed gene variants not previously connected with other neurodevelopmental diseases and uncovered new aspects of the complexity of genetic diseases.
GLRA2 was one gene we specifically focused on to follow up,Dr. Ronit Marom, assistant professor of molecular and human genetics at Baylor and lead clinician of this work said. We identified 13 patients, five males and eight females, carrying rare variants of this X-linked gene that had not been established as a neurological disease gene before. Furthermore, males and females carried variants with different types of functional consequences and the spectrum of neurological characteristics among these 13 patients was different between the two groups. For instance, many of the boys carried loss of function variants and had ASD, while the girls did not. They mainly presented with developmental delay as the main characteristic of their condition, and carried gain of function variants.
The picture that emerges is that ASD may not be one disorder involving many genes. It may actually be hundreds of genetic disorders, like those caused by certain GLRA2 variants, said Wangler, assistant professor of molecular and human genetics at Baylor and co-corresponding author of the work. We think that this information is important to physicians seeing patients with ASD.
Reference:Marcogliese PC, Deal SL, Andrews J, et al. Drosophila functional screening of de novo variants in autism uncovers damaging variants and facilitates discovery of rare neurodevelopmental diseases. Cell Rep. 2022;38(11). doi:10.1016/j.celrep.2022.110517
This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.
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Children infected with COVID-19 have natural antibodies that last for 7 months – Study Finds
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HOUSTON Children who get COVID-19 have natural antibodies that last for about seven months, according to a new study. But scientists say vaccines are still vital in order for them to get the best protection from the SARS-CoV-2 virus.
The study also shows that antibodies last the same amount of time in children whether they were asymptomatic or it was severe. It also does not matter whether they are at a healthy weight or obese, and there is also no difference by gender.
In the study, researchers at The University of Texas Health Science Center at Houston (UTHealth) examined data from 218 children between the ages of 5 and 19 who were enrolled in the Texas CARES study. The project assesses antibody status over time. Volunteers provided researchers with three separate blood draws, once during the COVID-19 vaccine rollout and again during the Delta and Omicron variants.
The study finds that 96 percent of the children infected with COVID-19 continued to have antibodies up to seven months later. Over half (58 percent) were negative for infection-induced antibodies at their third and final measurement.
To date, more than 14 million kids in the U.S. have tested positive for the virus. Study authors say even after their findings, its still wise for parents to have their kids vaccinated.
Adult literature shows us that natural infection, plus the vaccine-induced protection, gives you the best defense against COVID-19, says study co-author Sarah Messiah, a professor of epidemiology, human genetics, and environmental sciences at the schools Dallas campus, in a statement. There has been a misunderstanding from some parents who think just because their child has had COVID-19, they are now protected and dont need to get the vaccine. While our study is encouraging in that some amount of natural antibodies last at least six months in children, we still dont know the absolute protection threshold. We have a great tool available to give children additional protection by getting their vaccine, so if your child is eligible, take advantage of it.
The study is published in Pediatrics.
South West News Service writerJoe Morgan contributed to this report.
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‘There are two blood proteins that could hold the key to a long, healthy life’ – The Mirror
Posted: at 9:07 am
Dr Miriam Stoppard reports on a discovery which could help us to understand the ageing process and how key proteins could help us to live longer, healthier lives
Image: Getty Images)
For years, Ive followed the research on ageing that seeks to slow down the process. So are we any closer to achieving what could be the Holy Grail of medicine?
Studies from Edinburgh University investigating which proteins could influence how we grow old hint that we might be.
In the largest genetic study of ageing, scientists have uncovered two blood proteins that influence how long and healthy a life well live.
Their ambition is to develop drugs that target these proteins as a way of slowing down the whole process.
From adulthood onwards our bodies are in inevitable decline, which results in age-related diseases and eventually death.
The rate at which we age and die depends on genetics, lifestyle, environment and chance. This study reveals the part played by the proteins (the genetics) in this process.
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Our levels of these are determined by the DNA we inherit from our parents and they, in turn, affect our health.
Scientists combined the results of six large genetic studies into ageing totalling hundreds of thousands of people. They studied 857 proteins and identified two that had powerful negative effects on growing older.
For instance, people who inherited DNA that causes raised levels of these proteins were frailer, had poorer self-rated health, and were less likely to live an exceptionally long life than those who didnt.
So, what do these proteins do? The first, LPA, is made in the liver and thought to play a role in blood clotting.
High levels of LPA can increase the risk of hardening of arteries which leads to heart disease and stroke.
The second protein, VCAM1, resides on the lining of blood vessels and controls their expansion and contraction in blood clotting and the immune response.
Levels of VCAM1 increase when we have an infection and this gingers up the immune system.
The researchers say with drugs that lower levels of LPA and VCAM1, we might improve the quality and length of our lives.
Theres already a clinical trial testing a drug to lower LPA as a way of diminishing the risk of heart disease, and VCAM1 in early animal studies improved cognition during old age.
The identification of these two key proteins could help extend the healthy years of life, says Dr Paul Timmers, lead researcher at the MRC Human Genetics Unit at Edinburgh University.
Drugs that lower these protein levels in our blood could allow the average person to live as healthy and as long as individuals whove won the genetic lottery and are born with genetically low LPA and VCAM1 levels.
Brave new world!
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Citizens’ jury needed to deliver verdict on use of genomics in State – The Irish Times
Posted: at 9:07 am
A citizen jury of 25 people is being sought to consider how should genetics be applied and regulated with a view to improving health outcomes in the Irish population and providing oversight.
While the human genome has the potential to be used to improve and save lives, deploying genomics and gene technology in treatment and research is one of the most challenging medical ethical issues facing regulators and governments, as it is not without risks.
To consider how future regulation should be shaped, the Irish Platform for Patients Organisations, Science & Industry (IPPOSI) in collaboration with Royal College of Surgeons in Ireland (RCSI) Public Patient Involvement Office, is attempting to reach a verdict through a group broadly representative of the Irish population. It will be presented to the Government and policymakers to help shape future regulation.
Members of the public will be invited to hear arguments for and against, and to deliver judgment. They will be guided by an independent oversight panel with representatives from Rare Diseases Ireland, Health Research Charities Ireland and RCSI University .
The initiative was an opportunity to seek the publics views on an area urgently needing robust oversight, said IPPOSI board member, said Prof Orla Hardiman.
The human genome is the blueprint for our bodies. Made up of DNA, no human genome is the same, and tiny glitches in that DNA can give rise to serious illness and disability. Developing genomic medicine that is specific to a persons DNA can have a transformative effect on their lives and future health and wellbeing, as well as for wider society, she said.
There was a need to maximise benefits and to minimise risks that come with genomic research and to ensure appropriate structures and guidelines are in place so that everything we do benefits us collectively as a society, said Prof Hardiman.
As a doctor and a scientist, I have seen the benefits of genomic research. But at the moment, as a society, we need to understand what the best approaches are that will allow us to conduct meaningful research that benefits everybody. Its important that we hear from the Irish people about what they are comfortable with when it comes to giving consent for genetic research, and the types of information that is needed to understand how their genetic data will be used, she added.
IPPOSI is a patient-led, non-profit alliance of 105 patient organisations, more than 250 scientists and 23 companies that work together to improve lives of people with a chronic and/or rare disease.
Its chief executive, Derick Mitchell, said genomic research was a double-edged sword, while the Government and policymakers needed to consider views of the public.
There are many challenges around genomics. Notwithstanding these, many of IPPOSIs members living with chronic and rare diseases believe that if we get it right, it offers the potential for scientific and medical breakthroughs that will enable patients receive a quicker diagnosis and a treatment plan that is personalised to them.
Genomics could also potentially be used for other less altruistic purposes, he acknowledged. Conceivably, employers, banks, insurance companies and businesses could use this information to discriminate against one person over another in the provision of services.
They wanted to explore opportunities presented by genomics, as well as challenges that may arise from a social, ethical, legal, and practice point of view. What rules do we need to have in place around how genetic information is stored, who can access it, whether the information can be deleted on request, and safeguards to protect it from getting into the wrong hands?
Potential jurors do not have to have a science or medical background, or know anything about genomics. During June 2022, jury members will meet for sittings chaired by an independent facilitator. They will have the opportunity to hear testimony and to cross-examine witnesses who are expert not only in the field of genomics but also in areas of medical care, ethics and law.
The verdict, once announced, will be considered in follow-on deliberative dialogue workshops during September. To be a member of the jury, people must be over 18 and living in the Republic. Successful applicants will be randomly selected through an independent process overseen by an academic expert in data protection, informatics and ethics, to ensure representation from a cross-section of the population.
For further information and to make an application, visit ipposi.ie the closing date is Wednesday March 23rd.
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Part II: How COVID upended the taboo on limiting constructive discussion about human biodiversity – Genetic Literacy Project
Posted: at 9:07 am
The coronavirus crisis has brought to light the societal downside of ignoring patterned, population-based differences. Consider the latest research findings of a specific gene highly prevalent in South Asian populations (but not European ones) that doubles the risk of respiratory failure from COVID-19. COVID has also revealed numerous other examples of susceptibility differences, with study after study (after study after study, and yet more studies) indicating likely population-based (racial) variation in COVID-19 immunity.
Early in the COVID pandemic, we raised the possibilitylikelihood reallythat the genetic make-up of sub-Saharan Africans is the most plausible explanation for why that populous region remains the global cold spot for both infections and deaths from COVID. This is an outcome wholly unanticipated by the medical establishment which unanimously believed the poorest continent in the world, with the worst health care systems, was likely to face catastrophic devastation from the disease. Instead, the opposite happened. Here is a visual representation of deaths per capita (as of March 14, 2022):
Combined with the fact that sub-Saharan Africa is the youngest region in the worldyouth brings fewer co-morbidities and age is the most significant factor in contracting and dying from COVID-19ancestry is likely a significant contributing factor to to the regions comparatively modest case and death count.
What genetic factors could be impacting COVID-19 infection and death rates? Research and informed speculation are already underway. An early study on the possible contribution of genetics to the SARS-CoV-2 infection found significant population-based differences in ACE2 receptors that modulate blood pressure in the cells located in the lungs, arteries, heart, kidneys, and intestines. Africans are considerably less likely than East Asians to express the ACE2 receptors, though slightly higher than Europeans, the researchers believe.
At least two studies show that blood type O could be associated with a lower risk of COVID-19 infection and reduced likelihood of severe outcomes, including organ complications. About 50 percent of Africans have blood group O, the highest in the world. Susceptibility to the coronavirus is negatively associated with having a genetic propensity to absorb Vitamin C, as is the case with black African populations. Across Africa, roughly 50 percent of people carry the Vitamin C-friendly variant and in some African countries, it is as high as 70 percent.
Do Neanderthal genes increase the risk of COVID-19?The answer is yes. In fact, the presence of a Neanderthal gene is the single biggest genetic risk factor for the novel coronavirus, roughly doubling the likelihood of getting the virus. This particular stretch of Neanderthal DNA is carried by around 50 percent of South Asians, 16 percent of those of European descent, but not in any native Africans.
Why have journalists mostly ignored this monumental story while health officials, well aware of this astonishing development, also remain mum? Its the stigma of being associated with those who acknowledge that human biodiversity is a realitythat there are population-based differences that impact disease susceptibility. In contrast to this deafening silence, we addressed the astonishing reality of the situation in Africa, and the strong social and ethical reasons why we should not ignore possible racial differences in susceptibility to COVID-19 (and other diseases).
It is really mind boggling why Africa is doing so well, while in US and UK, the people of African ancestry are doing so poorly, Maarit Tiirikainen, a cancer and bioinformatics researcher at the University of Hawaii Cancer Center, told us in an email. Dr. Tiirikainen is a lead researcher in a joint project at the University of Hawaii and LifeDNA in what some believe is a controversial undertaking considering the taboos on race research. The scientists are attempting to identify those that are most vulnerable to the current and future SARS attacks and COVID based on their genetics.
A spate of new ancestral-linked evidence was brought to light by the novel coronavirus, but a wider perspective shows decades of long-established research on the clear links between genetic ancestry and specific diseases. Because many disorders disproportionately affect poor or marginalized peoples, neglecting such findings can have the worst impact on those most in need. As the distinguished journal Nature has written:
Genome-wide association studies (GWAS) have laid the foundation for investigations into the biology of complex traits, drug development and clinical guidelines. However, the majority of discovery efforts are based on data from populations of European ancestry.. In light of the differential genetic architecture that is known to exist between populations, bias in representation can exacerbate existing disease and healthcare disparities
For critics arguing to censor all talk of human biodiversity, are you willing to contend that such life-saving research should be supressed lest neo-Nazis begin bragging about both their lactose tolerance- and COVID-superiority? (That is in fact an argument advanced by some post-modernist sociologists and social equity promoting extremists.) Or, would it not be better to use data on genetic differencesthat is, on human biodiversityto advance science to help people who might otherwise die from coronavirus infection?
The growing evidence of the critical importance of pursuing the genetic analysis of populations brings to the fore a fascinating phenomenon in its own right: why many people who classify themselves as liberals or progressives remain reluctant to engage on the fact of evolved human biological diversity, despite overwhelming evidence. Even more startling, they not only wont talk about it, they reflexively attack anyone, including other liberals and progressives, who broach the subject.
This is dangerous territory. Although it is certainly true that all ideas are filtered through a prism of personal beliefs and cultural biases, its dangerous to hyperbolize that if some scientific evidence makes some uncomfortable, it should not be expressed. An overblown fear of racist misrepresentation of human genetics concedes the argument to bigots.
Indeed, by rejecting the fact of evolved human differences in some aspects of human development, well-meaning people undermine their own quest for greater social justice and racial equality. Its far more productive to openly, if carefully, embrace human genetic diversity in the same way we do with cultural diversitya position inspired by biologist E.O. Wilsons emphatic belief that we are not compelled to believe in biological uniformity in order to affirm human freedom and dignity.
Those who question research into human genetic diversity believe that evidence of racial differencebeyond obvious superficial features such as skin coloris socially divisive. It leads inevitably, they say, to racist musings about differences in intelligence and behavior. In the widely-held liberal view, humans are mostly a blank slate, with patterned human differences, random and mostly superficial. The idea that racial differences are more than skin deep is tantamount to promoting racialism (the belief that race determines human traits and capacities). And racialism, according to the analysis of liberal philosopher Michael Hardimon, provides a rationale for racism, slavery, colonization, or genocide:
It motivates the step from (a) representing another group as racially different to (b) taking these differences to be humanly important, to (c) regarding the other group as inferior, and (d) making it the object of hatred and contempt, to (e) imposing upon it involuntary servitude or (f) colonial rule, or (g) attempting the liquidation of all its membersa sequence of steps historically all too familiar.
In other words, if we begin by accepting racial difference, by this measure, critics say, we are on the slippery slope to justifying genocide. This goes to the heart of liberal concern about human biodiversity: the implicit belief that, if racial differences do exist and they are more than superficial, then racism (and worse) is nigh on inevitable. Unfortunately, casting the subject as totally off limits plays right into the hands of the racists themselves, letting them claim they are simply revealing the biological truths that their opponents wish to hide.
Why does this have to be the case? Why should possible evidence of human patterned biological diversity inevitably encourage racism? In fact, history suggests that ignoring this evidence is as likely or more so to promote racist notions.
A tried and tested means to reduce inter-group tension, one enthusiastically adopted by authoritarian regimes throughout history, is to impose cultural uniformity upon the wider population (an obvious recent example being the forced Sinicization of Tibetans, Uighurs and other ethnic groups in modern-day China). In more open societies today, however, cultural homogenization goes against the cherished liberal ideals of freedom and self-expression, where difference is not just to be tolerated but extolled. Except, of course, when focusing on the vexed question of genetic difference, where the ideal of uniformity in the name of equity is strictly enforced.
It neednt be this way. If we can come to value cultural differencedespite the troubling potential for social discordshould we not do the same with biological diversity? Here we can return to the broadminded moral arguments of the late E.O. Wilson:
Perhaps the time has come, he suggested, to adopt a new ethic of racial and hereditary variation, one that places value on the whole of diversity rather than on the differences composing the diversity. It would give proper measure to our species genetic variation as an asset . Humanity is strengthened by a broad portfolio of genes that can generate new talents, additional resistance to diseases, and perhaps even new ways of seeing reality. For scientific as well as for moral reasons, we should learn to promote human biological diversity for its own sake instead of using it to justify prejudice and conflict.
So what would it mean if we adopted Wilsons idealistic new ethic and came to promote rather than to deny deeper human genetic difference? Different human groups, ones that sometimes, but not always, raggedly match the folk categorizations of race, can indeed be genetically distinguishable due to their divergent evolutionary histories. Yet Australian Aboriginals, say, and northern Europeans (and indeed North American Inuit)populations that are almost literally poles apartalso share common ancestry; they are living proof of Wilsons point that, far from being isolated in distinct races, our species is one great breeding system through which genes flow and mix in each generation. Humans move around and fool around.
Here we can begin to address the question with which we began: Is it racist to research or write about human biodiversity? The short answer is no. While modern genomics does reveal broad populationsthat sometimes overlap with popular racial categories, the wider picture shows fuzzy-edged human groupings, sometimes with meaningful phenotypic distinctions and sometimes not. Depending upon how one organizes the data, there could be dozens or hundreds of population groups, with some meaningful connections among groups.
This might appear a good point to conclude. There are numerous scientific and moral reasons to embrace rather than reject human biodiversity in the same way we do or try to do with human cultural diversity. To end here, however, would be to avoid the central, but often unacknowledged, liberal objection to the concept of human racial and hereditary variationwhat it suggests about possible differences in cognitive abilities and behavior. Everyone can acknowledge some patterned human differences shaped by the serendipity of evolution, such as Inuit body shape, say, or East African domination of long distance running driven by their unique physique and physiology. The subject becomes most toxic, however, when it extends to prickly yet nebulous issues such as human intelligence or character. We will explore these issues with care, underscoring each individuals uniqueness.As Wilson himself noted, Hope and pride and not despair are the ultimate legacy of our genetic diversity.
Jon Entineis the foundingexecutivedirectorof theGenetic Literacy Project, and winner of 19 major journalism awards. He has written extensively in the popular and academic press on agricultural and population genetics. You can follow him on Twitter@JonEntine
Patrick Whittle has a PhD in philosophy and is a freelance writer with a particular interest in the social and political implications of modern biological science. Follow him on his websitepatrickmichaelwhittle.comor on Twitter@WhittlePM
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The Weight of Family History – The New Republic
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Ancestor Trouble does what all truly great memoirs do: It takes an intensely personal and at times idiosyncratic story and uses it to frame larger, more complex questions about how identity is formed. Using her own family tree, with its mix of colorful characters, closet-lurking skeletons, and truly vile monsters, Newton recounts the tall tales about these folks she grew up with before revealing what dogged and thorough research has turned up about their actual lives. Sometimes, these ancestors reveal themselves to be of surprising character. A great-grandfather, Charley Bruce, existed in her mother and grandmothers stories primarily as a man whod once killed another man with a hay hook. But through scraps of news accounts and trial records, Newton discovers a fuller picture: Charley was attacked by a former friend whod been convicted of sexual assault of a young girl; Charley had testified against him at trial, and the subsequent attack was revenge, the fatal blow struck by Charley an act of self-defense.
Others are far less redeemable. Newton turns up far more slave-owners in her lineage than she was expecting, not just on her racist fathers side but on her mothers, as well. And even some potential heroessuch as Mary Bliss Parsons, a distant ancestor in New England once accused of witchcraftturn out to be far from any kind of role model. Maude Newton, the ancestor after whom Maud (ne Rebecca) chose her pen name, was described to her by her mother and grandmother as an idiosyncratic and irascible iconoclast, a woman who chose to live an independent life in Texas. An autodidact who designed and built her own house, and a writer to boot, Maude seemed to have been a kindred spirit, or at least so Newton had hoped. But Maudes published writings (which took the form of a newspaper column from Drew, Mississippi) reveal a figure enamored with George Wallace and Barry Goldwater, who exhorted her readers to defy the Civil Rights Act to save their little white girl[s] from little Negro boys. Summing up this disappointing revelation, Newton writes, Im sorry that Maudes writing turned out to be what it was, but Im not sorry I found it, remembering, as she does throughout, that we do not dispel the ugliness of the past by ignoring it but by recognizing it and, ultimately, seeking restitution for the sins of the fatherand of the great-aunts, as well.
Family stories are one way our forebears pass down legacies to us; Newton also questions the inheritances of genes and heirlooms. The net effect is like watching a deft magician perform one trick after another and then patiently explain the secret and how youve been fooled. Newton will offer scientific research to suggest, for example, that mental health or temperament might be something that could be passed down generations, supplemented with detail from her own life (Later I learned that Charley had died from manic exhaustion, she says of her great-grandfather, and I remembered my own sleepless nights and scrabbling brain). But then shell swiftly move to unpack many of the problems with the same theory. She highlights not only the shaky scientific basis for our beliefs (Our science is only as good as the questions we ask, she reminds us) but also, quite often, the racist and ableist ideologies that underpin them. The idea of inherited mental traits, for example, which gained currency around the dawn of the twentieth century and still holds sway in popular imagination (and not just with people like Newtons father), was itself pushed heavily by eugenicists like Henry H. Goddard and his influential 1912 book, The Kalikak Family: A Study in the Heredity of Feeble-Mindedness. But Goddards central claim that all of the descendants of Martin Kalikak and his wife were normal, while those who descended from an affair with a feeble-minded barmaid turned out to be equally feeble-minded, was later found to be based entirely on altered and invented data.
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Genomics’ ethical gray areas are harming the developing world – ASBMB Today
Posted: at 9:06 am
Since the first human genome was sequenced in the early 2000s, scientists have touted the breakthrough as a blessing to humanity one that holds promise to promote human health and enhance medical treatment the world over. But around two decades later, the benefits of that scientific advancement have barely rippled out beyond Europe and North America. As of 2018, people of European ancestry who represented approximately 16%of the world population at the time made up 78%of all individuals whose genomes have ever been collected and studied.
DNA profile from a human sample.
Over the last decade or so, international studies on human population genetics have begun to expand genomic libraries to encompass regions of the Global South including Southeast Asia, where I am a science reporter, and the Pacific islands. These international studies, often led by Western scientists, have contributed to a more global understanding of ancient patterns of human migration and evolution. But on some occasions, theyve also sidestepped local regulatory agencies in the developing worldand ventured into murky research ethics terrain as a result.
A recent example a case that simultaneously illustrates the promise, pitfallsand pressure points of international genomics research comes from the largest genetic study ever conducted in the Philippines, published last year in the Proceedings of the National Academy of Sciences. A team led by Mattias Jakobsson of Uppsala University in Sweden and Maximilian Larena, who was a researcher in Jakobssons lab at the time, collected and analyzed DNA samples from more than 1,000 Filipinos representing 115 Indigenous groups. The study determined that todays Filipino population descends from at least five distinct waves of human migration, spanning thousands of years a finding that they said contradicted the prevailing theory of how humans populated the islands.
One could see the Uppsala study as a model of international collaboration. The project was endorsed by the Philippines National Commission for Culture and the Arts, a government body that coordinates, fundsand makes policy for the preservation, developmentand promotion of Philippine arts and culture. It was also done in partnership with more than a dozen local Indigenous and cultural groups in the Philippines; the papers appendix acknowledges more than 100 Filipinos who assisted with the study in some way, and Larena is himself Filipino. And key portions of the research plan were approved by an ethics review board in Sweden.
But many bioethicists would argue that it is not enough for researchers who do a human genomic study on foreign soil to merely collaborate with local groups. Various ethics guidelines on health-related research including UNESCOs International Declaration on Human Genetic Data and international ethical guidelines published by the Council for International Organizations of Medical Sciences, or CIOMS, in collaboration with the World Health Organization advise researchers to seek approval from an ethics committee in the host country. Such reviews are critical, bioethicists say, because cultural and social considerations of research ethics might vary between countries. In low-resource countries especially, ethics reviews are essential to protect the interests of participants and ensure that data are used in ways that benefit local communities.
Nowhere in Larena and Jakobssons paper, or in any of the subsequent publications based on the Philippines study, does the Uppsala team mention obtaining such an ethics approval in the Philippines and Philippines officials say they never granted the team such an approval. Asked whether his group had obtained a formal ethics clearance in the Philippines, Jakobsson pointed to the projects endorsement from the National Commission for Culture and the Artsand wrote that part of the commissions mandate is to ensure that the research they support is in accordance with the ethical principles of research involving participants from the Indigenous communities. But the NCCA primarily supports research that is cultural, not scientific, in nature, and a government website outlining the commissions mandate, powersand functions makes no mention of any duties related to research ethics.
In a 2021 letter, the commissions executive director wrote that the agency has no mandate or authority to give ethical clearance and did not give ethical clearance for the Uppsala study. (I reached out to the commission for this story but did not receive a response.)
A failure to secure formal ethics clearance might be understandable if there were simply no official Filipino agencies equipped to provide that clearance. But the Philippines has such a body the National Ethics Committee, or NEC, which falls under the jurisdiction of the Philippine Health Research Ethics Board and the Uppsala researchers were no doubt aware of this. In 2014, as the researchers were laying the groundwork to begin collecting human samples, they actively sought the NECs approval.
That approval was never granted. Marita Reyes, then the chair of the NEC, said she noticed problems with the initial Uppsala application. For instance, it did not clearly describe how research participants would be recruited, and it lacked the proper paperwork for researchers who intend to ship genetic materials overseas, she told Undark in an email. Reyes asked the Uppsala team to fix the issues and also recommended that they collaborate with local researchers who were doing similar work at the Philippine Genome Center.
According to Jakobsson, the Uppsala researchers took issue with the stipulations levelled at their application, and they say the prospective collaborators at the Philippine Genome Center made troubling demands regarding control of the collected samples. Ultimately, the researchers withdrew their application altogether. Their rationale: They say their population genetics study was cultural, not health-related, and therefore did not fall under the jurisdiction of the NEC or the Philippine Health Research Ethics Board. Given that your good office does not have regulatory mandate on the nature of our study, Larena wrote to Reyes in an email, we humbly withdraw our application. In the ensuing months, the Uppsala team would go on to collect DNA from more than 1,000 Filipinos without ever receiving express ethics approval from the NEC.
The case created an uproar in the Philippines. In a public statement, Allen Capuyan, chairperson of the Philippines National Commission on Indigenous Peoples, condemned the study, saying the researchers showed a blatant disregard of critical policies governing scientific research in the Philippines. Leonardo de Castro, a Filipino bioethicist who now chairs Philippine Health Research Ethics Board, asserted that the Uppsala study did fall under the NECs jurisdiction, and he called on the journal that published the Uppsala work to issue a retraction. (I first learned of the controversy in 2018 from officials at the Philippine Health Research Ethics Board; Maria Corazon De Ungria, a laboratory director at the Philippine Genome Center, later contacted me about the matter as well.)
Meanwhile, the Uppsala researchers have maintained that they are absolutely certain that they abided by basic ethical principles of research involving humans, and they say that investigations by a Swedish ethics review board, by Uppsala University itself, and by scientific journals have cleared them of any wrongdoing.
Nevertheless, I believe the case exposes a glaring shortcoming in the regulation of international genomics research: Even if bypassing a formal ethics review does not violate the letter of the law on human genomic research, it at least seems to go against the spirit of trust and transparency that are the foundation for healthy international scientific collaboration principles enshrined in the UNESCO and CIOMS guidelines. The Uppsala team is hardly the first to wade into this gray area of research ethics. In 2018, I wrote about a team of mostly Danish and American scientists who conducted a genetic study of Bajau traditional divers in Indonesia and also failed to obtain ethics approval from a local review board.
Was the Uppsala team right to conclude that their study fell outside the jurisdiction of the Philippines health research regulatory framework? Some people seem to think so. In a letter of support to the researchers, an attorney with the National Commission for Culture and the Arts the Philippines group that supported the study affirmed that the nature of the Uppsala project was exclusively cultural and fell under NCAAs jurisdiction, rather than that of the National Ethics Committee or the National Commission on Indigenous Peoples. Hank Greely, a professor of law at Stanford University who specializes in biosciences, including bioethics, said that the study published in PNAS didnt appear to be health-related and suggested its reasonable to argue that health research guidelines shouldnt apply in this case, although that wouldnt mean that no ethical standards should apply.
But other bioethics experts including Triono Soendoro, the chair of the Indonesian Society of Ethics Committee for Research and Services say that ethics standards like those developed by CIOMS and enforced by the Philippine Health Research Ethics Board were clearly meant to apply broadly to research involving human biological samples, even studies that have non-medical purposes. Population genetics research that identifies subjects by social or ethnic group, as the Uppsala study does, is certainly covered by CIOMS, said Eric Juengst, a bioethicist and professor at the University of North Carolina at Chapel Hill.
Human genomic science is too important, too consequential, to allow this precarious state of affairs to persist. If we want science to serve the whole of humanity, we need a strong set of universally binding rules on research ethics rules that clearly give local authorities a voice on matters of research ethics in all studies involving human genetic sampling, not just those that are obviously medical in nature.
In the Uppsala case, for instance, a formal ethics review might have offered important safeguards to ensure participants were fully aware of how their samples would be used and stored. Although participants signed informed consent forms that laid out many details of the research, a copy of the form obtained by Undark did not mention that samples would be shipped out of the country, to Sweden, for sequencing and analysis. This information could conceivably have influenced a subjects decision to participate.
Formal ethics reviews are also crucial for ensuring that low-resource countries can freely and independently access data that might benefit the health and wellbeing of their people. Even genetic data obtained for purposes unrelated to health may later prove beneficial for medical purposes. More than 1,000 samples of genetic data collected in the Uppsala study are now stored in the European Genome-Phenome Archive, where a Data Access Committee now has sole power to determine who can use it for future studies although one condition must be that such research is in accordance with consent provided by study participants. (The archives website doesnt specify the members of the Data Access Committee assigned to the Philippines data set, but it lists Larena as the contact person.) There is no guarantee that research institutions in the Philippines will ever be able to make use of the largest human genetic dataset ever collected on its own soil.
The international scientific community must be proactive in raising the standards of global research ethics. Prestigious journals, the gatekeepers of science, should ensure that researchers who collect human DNA samples make every effort to secure formal ethics approvals in the countries where the sample collection is performed. They should also be transparent about investigations of ethics misconduct and involve ethicists from developing countries in those investigations whenever possible.
Human genomic science should not stop at merely satisfying our curiosity. It should also serve the poor and the marginalized. Otherwise, if history is any guide, it will lead only to increasingly extreme disparities between the Global North and the Global South.
This article was originally published on Undark. Read the original article.
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Genomics' ethical gray areas are harming the developing world - ASBMB Today
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