Daily Archives: March 17, 2022

NCAA tournament: Here are four solid bets to make the Sweet 16 – Yahoo Sports

Posted: March 17, 2022 at 3:18 am

After spending the last 24 hours crafting a bracket built to withstand the chaos that awaits us on Thursday, bettors get their first taste of the NCAA Tournament on Tuesday night. The First Four provides a way to start the tournament with a few wins under our belt, but it's important to realize that we aren't limited to those single-game markets. Now that you have finalized your bracket and analyzed all 32 matchups, it's the perfect time to focus on March Madness futures.

The majority of the betting conversations revolve around which teams will make the Final Four or which team will be this year's Cinderella. As much as we love a Cinderella story, those underdogs usually meet their fates before escaping their region. Their story still has value, and you can capitalize on their run by targeting the Sweet Sixteen market. It's one of my favorite bets for several reasons.

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By betting teams to reach the Sweet Sixteen, it allows you to get decent value on schools that are underrated and have an advantageous path without having to bank on them winning four or five games in a row. There are only a few teams that are built to win consecutive games against the country's elite, but there are plenty of teams that can make some noise. I looked at four teams that include a mix of conservative bets at close to even money and two more aggressive plays at longer odds. BetMGM offers odds on every single team to make the Sweet 16, so grab your bracket and let's find some winners.

All lines via BetMGM.

Arkansas and coach Eric Musselman could be primed for an NCAA tournament run. (Photo by Peter Joneleit/Icon Sportswire via Getty Images)

Arkansas (+110)

The Razorbacks finished the season on a 15-3 run that included wins against the SEC's toughest competition. They should handle business pretty easily against Vermont, leaving a potential showdown with UConn in the second round. The Huskies' length can be a challenge for any offense, but I'm confident in the Hogs' ability to get to the line. Arkansas guard J.D. Notae wants the ball in his hands at the end of the game and with a swarming defense backing him, the Razorbacks are a solid bet to advance to Sweet 16.

Story continues

Houston (+115)

The biggest knock on Houston is always the level of competition, but last year's Final Four run shows it is built for tournament success. The Cougars are one of two teams (along with Gonzaga) that rank in the top 12 of KenPom's efficiency metrics in both offense and defense. Coach Kelvin Sampson's team might win ugly, but it's a style of play bettors can count on. Houston's path looks tough on paper, but Illinois has struggled at times against strong, defensive teams that play physically. Houston at +115 makes a lot of sense.

Loyola Chicago (+400)

The story of Sister Jean lives on! I am betting there is one more run left in Loyola Chicago's tank as it gets the perfect opponent to open the tournament. We know the Ramblers will do their job defending, but the Buckeyes' defensive struggles really open the door for an upset. Ohio State ranks 131st in defensive efficiency and has lost four of its last five games heading into the tournament. To get to the Sweet 16, the real test will come in the second round against No. 2 seed Villanova. If the Ramblers lock down Collin Gillespie and force Nova to use its secondary scorers, they may have a shot.

Colgate (+2000)

Colgate fits the profile of a long shot that is worth backing. It is an elite 3-point shooting team (40.2%) that has won 19 of its last 20 games. A team playing with confidence without anything to lose is a dangerous combination in March. Colgate's path is what got my attention. It faces a reeling Wisconsin team in Round 1 that is coming off back-to-back losses. If it can get past the Badgers, the winner of Iowa State and LSU stands in the way of the Sweet 16. Three points are worth more than two, and neither of those teams can keep up with Colgate's shooting if it comes out scorching from beyond the arc. A 20 to 1 bet is always going to require a good share of luck, but it's worth a small stake considering the price.

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2022 men’s NCAA tournament viewing guide: What to watch and what to skip on Thursday – Yahoo Sports

Posted: at 3:18 am

Welcome to the 2022 NCAA tournament. The tournament tips off in earnest just after noon on Thursday with Colorado State and Michigan. That's the first of 16 games throughout the day as we'll get an awesome 12 hours of basketball that will likely include an upset or three. Here's your viewing guide for the first full day of the 2022 men's tournament. All times are Eastern.

12:15 p.m.: No. 6 Colorado State vs. No. 11 Michigan (CBS)

12:40 p.m.: No. 4 Providence vs. No. 13 South Dakota State (TruTV)

1:45 p.m.: No. 8 Boise State vs. No. 9 Memphis (TNT)

2 p.m.: No. 1 Baylor vs. No. 16 Norfolk State (TBS)

Must-see: After tuning into the first few minutes of Colorado State and Michigan you need to have your attention on South Dakota State and Providence. The Jackrabbits are picked by nearly 30% of Yahoo users to pull the upset and are just 2.5-point underdogs to the Friars. SDSU went undefeated in the Summit League this year while Providence had a bunch of close wins. This could be a great one.

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Must-skip: Baylor should make easy work of Norfolk State. While you may need to spend some time watching this one because its the final game of the early session, itll probably be a blowout by the time you turn it on. The other three games should be much more competitive.

2:45 p.m.: No. 3 Tennessee vs. No. 14 Longwood (CBS)

3:10 p.m.: No. 5 Iowa vs. No. 12 Richmond (TruTV)

4:15 p.m.: No. 1 Gonzaga vs. No. 16 Georgia State (TNT)

4:30 p.m.: No. 8 North Carolina vs. No. 9 Marquette (TBS)

Must-see: North Carolina is favored by 3.5 points over Marquette in a game that could be the only close one of this set of games. The Eagles beat Villanova twice this season while North Carolina beat Duke to end the regular season. Both teams score over 74 points per game so this could be a race to 80.

Must-skip: Check the score on Gonzaga and see how star freshman Chet Holmgren is doing and thats about it. Theres a little more upset potential with Longwood and Richmond, but UNC and Marquette should take most of your attention late in the afternoon.

Story continues

North Carolina takes on Marquette in the first round of the NCAA tournament on Thursday. (Photo by Rich Graessle/Icon Sportswire via Getty Images)

6:50 p.m.: No. 5 UConn vs. No. 12 New Mexico State (TNT)

7:10 p.m.: No. 2 Kentucky vs. No. 15 St. Peters (CBS)

7:20 p.m.: No. 5 St. Marys vs. No. 12 Indiana (TBS)

7:27 p.m.: No. 8 San Diego State vs. No. 9 Creighton (TruTV)

Must-see: You know how we said that North Carolina and Marquette could be high-scoring? Thats not going to be the case between San Diego State and Creighton. San Diego State allows 58 points per game and Creighton has allowed 65 points or fewer in each of its last five games. The total for this one is just 119 points. But it should be exceptionally close and dont be surprised if its a one-score game with under a minute left.

Must-skip: Sorry St. Peters, we arent putting much stock in your ability to hang with Kentucky. Indiana is capable of pulling off a 12-5 upset over St. Marys and New Mexico State is just a 6.5-point underdog against UConn. Kentucky should win this one easily and you could be flipping back and forth among the other three games.

9:20 p.m.: No. 4 Arkansas vs. No. 13 Vermont (TNT)

9:40 p.m.: No. 7 Murray State vs. No. 10 San Francisco (CBS)

9:50 p.m.: No. 4 UCLA vs. No. 13 Akron (TBS)

9:57 p.m.: No. 1 Kansas vs. No. 16 Texas Southern (TruTV)

Must-see: If youre a casual college basketball fan you likely havent seen any Murray State or San Francisco games this season. Change that late Thursday night. The Racers are 1.5-point favorites in this one and average nearly 80 points per game. San Francisco has scored 77 per game and shoots a lot of threes. Youll be entertained.

Must-skip: There wont be a UMBC moment on Thursday and all No. 1 seeds should win easily. If youre in the Eastern or Central time zones you can probably head to bed after UCLA and Akron because Kansas should have things under wraps by early in the second half at the latest against Texas Southern.

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Tim Hortons to open first India location as it expands internationally – Yahoo Canada Finance

Posted: at 3:18 am

Tim Hortons said it will open its first location in India later this year. (Photo by Lin Zejun/VCG via Getty Images)

Tim Hortons is expanding, bringing its double-doubles and Timbits to India as the chain looks to open hundreds of new locations around the world.

The coffee and doughnut chain announced on Tuesday that it has reached an agreement with a joint venture owned by Apparel Group and Gate Partners and will open its first India location in New Delhi later this year. Tim Hortons parent company Restaurant Brands International (QSR)(QSR.TO) says there are plans to open 300 locations in India over the next decade.

"India is one of the world's fastest growing markets for coffee and tea retail chains and Tims is thrilled to be opening there soon," David Shear, president of RBI, said in a statement.

"This launch in India is another critical step in our continuing international expansion plans."

Tim Hortons is in the midst of an aggressive international expansion strategy, with a particular focus on China. The company opened its 400th location in China in January, less than three years after it started its first restaurant in the country.

"We're really excited about the progress we're making in Tims in China," chief executive Jose Cil told analysts on a conference call last month, adding that the brand is gaining traction in other international markets as well, including the Middle East, United Kingdom and Mexico.

"We have a very ambitious long-term target for growth in China and view that as a great path to build Tim's international business throughout the region in Asia and also in other markets around the globe."

India will mark the 14th country that Tim Hortons will operate in. The chain currently has 5,100 locations in 13 countries, including the U.S., Mexico, Spain, the United Kingdom, China, Thailand, the Philippines and across the Middle East.

Alicja Siekierska is a senior reporter at Yahoo Finance Canada. Follow her on Twitter @alicjawithaj.

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Tom Aspinall’s wayward path to UFC spotlight: ‘Im just trying to be me’ – Yahoo Sports

Posted: at 3:18 am

After taking out Sergey Spivak in the first round in September which earned him his third $50,000 Performance of the Night bonus a humbled Tom Aspinall called out Blagoy Ivanov, who was ranked 12 at the time.

The UFC didnt pay attention to that call-out. Instead, it put Aspinall in with No. 6 Alexander Volkov on Saturday (4 p.m. ET, ESPN+) at The O2 Arena in London, giving him a considerably tougher test.

And Aspinall, who won over so many fans after beating Spivak by showing his humility while talking about his desire to buy his family a home, thought the UFC had the best idea.

So, the hometown boy will meet Volkov in the first UFC card in the United Kingdom in three years with a lot on the line.

After Aspinall watched the Spivak bout, he agreed with the UFCs choice to have him fight Volkov and not Ivanov. Hes become a vastly different fighter.

Anytime you can get a win in the UFC, its impressive, said Aspinall, who is 11-2 overall and 4-0 in the UFC. But when you can get a win and not really be touched in the fight, it just really shows your level. It proves to yourself that what youve been doing is really working. My confidence since that fight has gone to a whole other level. Ive always been confident anyway in my own skills, my own ability, but I feel like now my skill level is very high.

He cringes when he speaks that way, because hes the opposite of a loud-mouth, self-absorbed trash talker. He carries himself with humility and isnt looking for attention or to make a name for himself with anything other than his ability.

In Las Vegas, he was caught on camera crying when he heard news that hed won a $50,000 bonus. He said at the news conference that night hed been saving to buy his family a home.

He took pains to point out that his emotion he showed upon learning hed gotten a bonus was real and hes not trying to manufacture a character.

What you see with Aspinall is what you get, and people are taking to him.

Story continues

These answers, theyre not so I come across humble or anything like that, Aspinall told Yahoo Sports. Theyre honest answers. Im not trying to come across any certain way. This is literally my honest answer. I see a lot of people giving these fake answers to try to come across a certain way and I dont like that stuff. Im just trying to be me. Some people yelled at me for tearing up on camera when I got the bonus, but I didnt even know there was a camera there. I had no idea. It was a guy with a phone in his hand. If it was up to me, that video wouldnt have been posted. I dont want to be crying on camera.

But I have bought a house for the family and we are in the house as of two months ago. Its amazing times to be 28 years old with three children and a wife and being able to support everybody. Great times.

Tom Aspinall takes a big step up in competition Saturday when he faces Alexander Volkov (not pictured) in the main event of UFC London. (Photo by Jeff Bottari/Zuffa LLC)

Many fighters who have had success at a young or in a lot of cases, not such a young age wind up getting self-absorbed and many blow their fortunes not long after they get it.

If Aspinall defeats Volkov, hell likely be in or right near the top five of the heavyweight division and thats where the big money will start to come. Aspinall, though, said the money, fame and attention wont change him or see him all of a sudden develop an entourage the size of a small town in northern England.

His father will be a gatekeeper, he said, but its just not in Aspinalls nature to be that way.

[My father] is not just going to let some guy from off the street come in and start sweet-talking me and start taking all of my money, Aspinall said. No way. Theres absolutely no way hes going to let anything like that happen, so I dont even have to worry about it.

What he does have to worry about is Volkov, an elite heavyweight whose losses have come primarily against the best of the best. BetMGM has Aspinall as a -130 favorite, with Volkov at +110.

Aspinall has much respect for Volkov, but his body of work convinced him he was ready for this opponent at this stage of his career.

He brings so many problems, Aspinall said. Hes 6-foot-8 and as you just mentioned, he has so much more experience than me. I was told today that hes got more knockouts than I have fights. Hes got a lot of knockouts. Hes got a lot of five-rounders under his belt. Hes got a lot of three-rounders under his belt, so the experience is there. Hes been fighting at a high level. Hes fought in front of large crowds. Ive never fought in front of a full-capacity crowd before.

On paper, it looks like its a mismatch in his favor. But paper doesnt really mean anything when it comes to stepping into the Octagon and fighting. Nobody really has an idea of what I can do in the Octagon. People think theyve got an idea, but Ive shown minimal, the minimum of my skill set is what Ive shown so far.

Saturday in front of a huge throng cheering his name would be a good time for him to show those skills. And dont be at all surprised if he does, and in a big way.

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PGA Tour betting: Viktor Hovland is the top pick of bettors ahead of Valspar Championship – Yahoo Sports

Posted: at 3:18 am

Viktor Hovland is bettors most popular choice in a solid field at the Valspar Championship.

Five of the worlds top 10 golfers are entered in this weekends tournament at the Copperhead Course at Innisbrook Resort in Palm Harbor, Florida. Hovland, the No. 3 golfer in the world, is the No. 2 favorite for the tournament at +1000 at BetMGM. Hes getting 6% of bets to win the tournament and is the only player getting more than 10% of the money bet on the winner of the tournament.

World No. 1 Jon Rahm isnt entered this week so Collin Morikawa is the top player in the field. Morikawa is the No. 3 favorite in the field at +1100. Hes getting 4% of bets and the second-most money behind Hovland at 9.2% of the handle.

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The favorite for the weekend is Justin Thomas at +900. Hes getting just over 4% of wagers and under 8% of money wagered.

The second-most popular pick to win is Dustin Johnson at +1400. Hes getting just under 5% of bets, though those bets make up just under 5% of the total money wagered.

The other top-10 player entered in the field is Xander Schauffele. The Tokyo Olympics gold medalist is at +1800 to win and is getting 3% of bets and 2.4% of the money to win the tournament.

The Valspar is the last tournament of the PGA Tours spring Florida swing. The World Golf Championships match play event is next week and will feature dozens of the worlds top players. The Texas Open is the first event of April and is the last full-field event before the Masters which begins on April 7.

Viktor Hovland is the No. 2 favorite ahead of the Valspar Championship. (AP Photo/Gerald Herbert)

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NBA betting: How to bet Celtics-Warriors on Wednesday night – Yahoo Sports

Posted: at 3:18 am

We have one night left until the biggest day in college basketball consumes us with 16 games of pure mayhem. For Wednesday night we're looking at the NBA card to give our bankroll another boost before one of the biggest sports betting weekends of the year. All three bets hit from Monday's side, total, and prop, giving us a clean 3-0 sweep on the night. Let's keep the momentum rolling as we dive into Wednesday night's 12-game schedule.

Draymond Green played 20 mins and posted seven rebounds and six assists in his return from injury Monday night. The Warriors cruised to their fourth straight victory and fifth straight cover. Call me a contrarian, but I am not buying everything is perfect again in Dub Nation. I am not saying the Warriors won't be in form by the postseason, but the Boston Celtics are a great litmus test for any team.

Golden State's offense looked outstanding facing one of the worst defenses in the NBA on Monday night. Unfortunately, that level of competition against Washington doesn't provide much predictive value. The Celtics' superior defense travels well, stifling opponents at a rate of 105.7 points per 100 possessions in road games. I think they can bottle up Curry enough and test Golden State's depth. Both defenses will bring maximum effort, making the points with the dog even more valuable. The C's are 6-3 ATS in their last nine on the road and have covered in five of their last six trips to the Bay. I will take the points and bank on Tatum keeping them close.

The Wizards are happy to be home after a winless West Coast road trip in which they allowed more than 122 points per game. Before the Warriors scored 73 points in the first half Monday night, Washington gave up over 120 points per game to three bottom-eight offenses. Their 123.4 defensive rating for the month of March is an embarrassing 29th in the NBA. They are also 29th in their last 15 home games, making it very unlikely the hometown crowd sparks a defensive effort against Denver.

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Nuggets MVP candidate Nikola Jokic should beef up his case in a big way. The Wizards allow the fifth-most points to centers, and Denver will be motivated to catch the Jazz and Mavericks in the Western Conference standings. Washington is on a five-game run to the over and has been a sneaky-good offensive team with Kristaps Porzingis. This is a great situational spot to push the over streak to six.

Philadelphia was the big trade deadline winner but has been losers of late ever since the schedule leveled up. The 76ers have lost three of their last five and are desperate to get their Big 3 back on track and that includes Tyrese Maxey. After averaging over 26 points in his first four games with James Harden, Maxey's scoring production dropped to 13.4 points over the last five games. Philly missed his scoring touch, going 2-3 during his struggles.

The trend is clear that the Sixers need Maxey to be more assertive, and Wednesday night's opponent should give him the confidence to do so. Maxey scorched the Cavs for 33 points on 10-of-15 shooting less than two weeks ago. He gets another opportunity against that same Cavs defense. I expect a big push from Joel Embiid and Harden to get him touches, making me comfortable that the second-year guard delivers.

Stats provided by teamrankings.com, evanalytics.com, and nba.com.

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The Rush: Kyrie Irving drops 60, Aaron Judge drops the ball on Covid vaccine – Yahoo Sports

Posted: at 3:18 am

Kyrie Irving scores a career and Nets franchise high 60 points in win over Magic, NYC vaccine mandate will keep unvaccinated Yankees and Mets from playing in home games, Aaron Judge punts when asked if hes vaccinated against Covid-19, and March Madness is underway with Texas Southern and Indiana advancing out of the First Four! Plus, The Rush economics team gets hypothetical, exploring the potential monetary impact of a scenario in which an unvaccinated player were to only be compensated for away games in accordance with local vaccine mandates.

- Edwards, the handoff. Quick trigger, Irving, 60. 60, Kyrie Irving.

[MUSIC PLAYING]

JARED QUAY: We're going to talk Kyrie in a minute. But first, March madness is officially on and popping. The first four kicked off last night with Texas Southern and Indiana advancing to the main stage on Thursday for a round of 64. Now, the madness ain't exclusive to college basketball.

Yep, that's Colin Kaepernick throwing deep balls to Tyler Lockett. And I got to say Kaps On looks good. Now, is Kap going to be able to throw that ball with Aaron Donald coming straight for him? I don't know, but he deserves a chance to find out. What I do know is there's a lot of NFL teams who can use a starting quarterback with Super Bowl experience right about now.

Right about now I'm sensing the Yankees and Mets fans are freaking the [BLEEP] out. You know the New York City vaccine mandate that prevents unvaccinated Kyrie Irving from playing in Nets home games?

- Yeah, what about it?

JARED QUAY: You know because Kyrie won't get the jab to protect himself and teammates, he's got to save his career high 60-point performance for road games.

- Off the window.

JARED QUAY: Well, that mandate applies to the Yankees and Mets, too. So with that in mind on Tuesday, a reporter asked Yankees superstar Aaron Judge if he's vaccinated. This is his response.

AARON JUDGE: I'm so focused on just getting through the first game of spring training. So I think we'll, we'll cross that bridge whenever, you know, the time comes. But right now, so many things could change. So I'm not really too worried about that right now.

Story continues

JARED QUAY: Oh, OK, I guess Aaron's not too worried about only doing half his job this season.

- OK, well, I'm worried.

JARED QUAY: I still have a tough time grasping this. So you're telling me the same group of people who take all kinds of supplements that aren't FDA approved, who put metal pins under their skin to hold their bones together, who have ligaments from dead bodies insert into their bodies, who relieve pain with opioid pills and injections, you're saying some of these guys still won't take the COVID vaccine.

- It just don't make no damn sense.

JARED QUAY: No, it's sure don't. But if teams really cared about the safety of their employees, the'd put some money on the line. You only pay half of that schedule, you only get half of that paycheck.

- Come on.

JARED QUAY: For example, Aaron Judge is going to make $17 million this year.

- That's a lot of money.

JARED QUAY: If you cut his paycheck in half it turns to $8.5 million. Take half of that away to pay the tax man, and get down to $4.25 million, not even enough money to buy a fixer upper in Brooklyn. I'd change my mind real quick. Let's be honest, all right. If they tried to cut my percentage like 10%. We'll, give you 10% less. All right give, me three jabs. I want three of them. I want the booster on the same day as the second shot. Just give it to me.

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Psoriasis: Symptoms, Treatment, Images and More – DermNet

Posted: at 3:17 am

Author: Hon A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand, 1997. Revised August 2014. Skin of colour update: Dr Chelsea Jones, Resident Medical Officer, John Hunter Hospital, Newcastle, NSW, Australia; Dr Monisha Gupta, Dermatologist, University of NSW and Western Sydney University, Sydney, NSW, Australia. December 2020.

Psoriasis is a chronic inflammatory skin condition characterised by clearly defined, red and scaly plaques. It is classified into a number of types.

Psoriasis affects 24% of males and females. It can start at any age including childhood, with peaks of onset at 1525 years and 5060 years. It tends to persist lifelong, fluctuating in extent and severity. It is particularly common in Caucasians but may affect people of any race. About one-third of patients with psoriasis have family members with psoriasis.

Psoriasis is multifactorial. It is classified as an immune-mediated inflammatory disease (IMID).

Genetic factors are important. An individual's genetic profile influences their type of psoriasis and its response to treatment.

Genome-wide association studies report that the histocompatibility complex HLA-C*06:02 (previously known as HLA-Cw6) is associated with early-onset psoriasis and guttate psoriasis. This major histocompatibility complex is not associated with arthritis, nail dystrophy, or late-onset psoriasis.

Theories about the causes of hyperproliferation of the skin in psoriasis need to explain why the skin is red, inflamed, and thickened.

It is clear that immune factors and inflammatory cytokines (messenger proteins) such as IL1 and TNF are responsible for the clinical features of psoriasis. Current theories are exploring the TH17 pathway and release of the cytokine IL17A.

Psoriasis usually presents with symmetrically distributed, red, scaly plaques with well-defined edges. The scale is typically silvery white, except in skin folds where the plaques often appear shiny with a moist peeling surface. The most common sites are scalp, elbows, and knees, but any part of the skin can be involved. The plaques are usually very persistent without treatment.

Itch is mostly mild but may be severe in some patients, leading to scratching and lichenification characterised by thickened leathery skin and increased skin markings. Painful skin cracks or fissures may occur.

When psoriatic plaques clear up, they may leave brown or pale marks that can be expected to fade over several months.

Certain features of psoriasis can be categorised to help determine appropriate investigations and treatment pathways. Overlap may occur.

Post-streptococcal acute guttate psoriasis

Guttate psoriasis

Chronic plaque psoriasis

Flexural psoriasis

Scalp psoriasis

Sebopsoriasis

Palmoplantar psoriasis

Nail psoriasis

Erythrodermic psoriasis

Generalised pustulosis and localised palmoplantar pustulosis are no longer classified within the psoriasis spectrum.

Plaque psoriasis is the most common type of psoriasis in all racial groups. Non-Caucasians tend to have more extensive skin involvement than Caucasians. Asian populations are reported to have the highest percentage of body surface area involvement. In skin of colour the plaques are typically thicker with more pronounced silver scale and itch. The pinkness of early patches may be more difficult to appreciate resulting in a low PASI assessment. The thick plaques may appear violet or dark in colour. Plaque psoriasis commonly resolves to leave hyperpigmentation or hypopigmentation in skin of colour, which further impacts quality of life even after disease clearance.

Other types of psoriasis show variable rates in different skin types. Palmoplantar psoriasis is reported to be most common in the Indian population. Non-Caucasians are more likely to present with pustular and erythrodermic psoriasis than Caucasians, whereas flexural psoriasis is said to occur at a lower rate in skin of colour.

Plaque psoriasis in skin of colour

Patients with psoriasis are more likely than others to have associated health conditions such as are listed here.

Psoriasis is diagnosed by its clinical features. If necessary, diagnosis is supported by typical skin biopsy findings.

Medical assessment entails a careful history, examination, questioning about the effect of psoriasis on daily life, and evaluation of comorbid factors.

Validated tools used to evaluate psoriasis include:

The severity of psoriasis is classified as mild in 60% of patients, moderate in 30% and severe in 10%.

Evaluation of comorbidities may include:

Patients with psoriasis should ensure they are well informed about their skin condition and its treatment. There are benefits from not smoking, avoiding excessive alcohol, and maintaining optimal weight.

Mild psoriasis is generally treated with topical agents alone. Which treatment is selected may depend on body site, extent and severity of psoriasis.

Most psoriasis centres offer phototherapy(light therapy) with ultraviolet (UV) radiation, often in combination with topical or systemic agents.

Moderate to severe psoriasis warrants treatment with a systemic agent and/or phototherapy. The most common treatments are:

Other medicines occasionally used for psoriasis include:

Systemic corticosteroids are best avoided due to a risk of severe withdrawal flare of psoriasis and adverse effects.

Biologics or targeted therapies are reserved for severe psoriasis resistant to conventional treatment mainly because of expense, as side effects compare favourably with other systemic agents. They can also be used to treat concurrent psoriatic arthritis. These treatment include:

Many other monoclonal antibodies are under investigation in the treatment of psoriasis.

Oral agents working through the protein kinase pathways are also under investigation. Several JAK (Janus kinase) inhibitors are under investigation for psoriasis, including tofacitinib and the TYK2 (tyrosine kinase 2) inhibitorBMS-986165; both are in Phase III

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Psoriasis severity, body surface area, and psoriatic arthritis – Medical News Today

Posted: at 3:17 am

People with psoriasis have an increased risk of developing psoriatic arthritis (PsA). New research shows that psoriasis severity and body surface area play a role in determining the extent of the risk.

Psoriasis is a chronic, autoimmune disease that affects the skin, causing dry, itchy patches with a covering of scales. In the United States, more than 7.5 million adults are living with this skin condition, which equates to about 3% of the adult population.

PsA is a chronic, inflammatory type of arthritis that leads to symptoms such as joint pain, stiffness, and swelling. Although it is possible to develop PsA without having psoriasis first, up to 34.7% of people living with psoriasis worldwide develop PsA.

The collective name for these two conditions is psoriatic disease. Researchers have looked into the link between these conditions and how they affect one another. Of particular interest are predictive symptoms that may indicate whether a person with psoriasis will also develop PsA.

More recently, researchers have looked at how the severity of psoriasis may affect the onset of PsA. A 2021 study showed a correlation between more severe cases of psoriasis and the development of PsA.

This article explores what experts know about the connections between psoriasis severity and PsA.

Over the years, researchers have studied the connection between psoriasis and PsA. Part of what they have looked for is trends in symptoms that may predict the likelihood that a person with psoriasis will develop PsA, as well.

As more than one-third of people living with psoriasis may also develop PsA, understanding what risk factors to look for may help doctors diagnose the joint condition sooner. The earlier diagnosis and treatment of PsA may lead to better outcomes and improved quality of life.

In a 2009 study, researchers found that the presence of certain psoriasis symptoms may increase a persons risk of developing PsA. The findings showed a link between the presence of the following psoriasis symptoms and an increased risk of PsA:

In another study from 2010, researchers shared similar results. They noted that the following psoriasis symptoms or factors were positively associated with an increased risk of developing PsA:

Research is beginning to show that the severity of a persons psoriasis may indicate that they have an increased risk of developing PsA.

In one older study from 2010, researchers acknowledged that severe cases of psoriasis increased a persons risk of developing PsA.

In a more recent 2021 study, researchers noted the same association. However, they cautioned that these findings might not be generalizable to the larger population.

In another 2021 study, researchers argued that the total body surface area that psoriasis covers may help predict the likelihood of developing PsA. The study authors also noted depression and obesity as additional risk factors.

The Global Healthy Living Foundation notes that although anyone living with psoriasis can develop PsA, psoriasis that covers a larger area of the body puts people at higher risk.

The organization also lists additional risk factors that could influence whether a person with psoriasis goes on to develop psoriatic arthritis. These factors include:

Growing evidence suggests that the severity of psoriasis symptoms, including the amount of the body that they affect, directly corresponds with the risk of developing psoriatic arthritis.

People who receive a diagnosis of psoriasis should talk with the doctor about their individual risk of developing PsA. They should also inform the doctor if they start to experience any joint symptoms that may indicate PsA.

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Psoriasis severity, body surface area, and psoriatic arthritis - Medical News Today

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Measuring Outcomes for the Treatment of Psoriatic Arthritis – MD Magazine

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John Tesser, MD: Lets talk about successful outcomes and maybe measures of successful outcomes. What are our goals in treating patients? Let me frame this in the context of how we view or have measured rheumatoid arthritis. That has been an ongoing battle and a challenge for rheumatologists for decades: measuring rheumatoid arthritis using either the Disease Activity Score, the Clinical Disease Activity Index, RAPID3 [Routine Assessment of Patient Index Data 3], some of those, all of those, none of those. We appreciate very much that the ACR20 [American College of Rheumatology 20% improvement], ACR50, and the ACR70 improvement criteriawhich are used in judging success in clinical trialsare not used at all in clinical practice. Its a composite measure of many things, but that measure in and of itself doesnt identify how much inflammatory disease a person has at any given point in time.

In psoriatic arthritis, interestingly enough, ACR20, ACR50, and ACR70 in clinical trials are utilized as the measure of success for FDA approval for psoriatic arthritis trials. Its not the only thing thats measured, but the ACR20 is used as the lowest bar for approval. The CDAI [Clinical Disease Activity Index] is beginning to be used by some people.

But theres another measurement thats analogous to the ACR composite criteria. Its called the minimal disease activity index. It comprises similar things to whats in the ACR criteria, like how many tender and swollen joints and whats the patients global and pain, functionality, and acute phase reactantthis kind of thing. Its all put together, and if you measure these things on your patient, then you assign certain points to these things. If the patients meet many points, theyre identified as having low disease activity; even more points, very low disease activity. That measure exists. It has begun to be used in clinical trials. Nehad, do you think this is going to have any utility in clinical practice? What do you do in your practice in terms of identifying outcome measures? When you think youve achieved success, how do you assess it?

Nehad Soloman, MD: For a long time, we grappled with this, or at least I grappled with this: what do I use as an outcome measure? Just like with the drugs, we borrowed things from the rheumatoid arthritis experience. When you mentioned the ACR levels, you also mentioned CDAI.The easiest thing to do was obviously the CDAI, which measures tender and swollen joints and assessment both by physician and patient in terms of global experience. But when you think about minimal disease activity index, it also measures tender joints, swollen joints. It looks at the skin, body surface area, and PASI [Psoriasis Area and Severity Index]. It looks at visual analog scales from a pain perspective as well as a global perspective. Then it also looks at the HAQ [Health Assessment Questionnaire] and it adds the other critical point, which we do clinically but we dont quantify it by looking at enthesitis or entheseal point tenderness.

Beyond that, as Ive learned to examine this a bit closer, its meeting 5 of 7 areas and having them at a level of 1 or less in some areas, 3 or less if youre talking about body surface area. But theres a target at each of these. The challenge, although we do a lot of this in clinical practice, just like the ACR scores, we just dont quantify it. We say, Theres an improvement in tender joints or swollen joints, or SED [erythrocyte sedimentation] rate and CRP [C-reactive protein] have improved or have normalized. Thats the quick and dirty way of saying theyre getting better.

As payers demand and as patients demand a number or a target, we may find ourselves using this. To employ this so that we can inform treatment decisions, the world of IT [information technology] is going to meet medicine once more and find a way to make itself into our EHR [electronic health record] in a manner thats simple. If just like in our EHR, we can quickly insert these, whether part of it is imported from the patient questionnaire or part of it is actively recorded as were seeing the patient, then it may very well become more mainstream. But it will be years down the line when we can get this to be streamlined in the EHR.

John Tesser, MD: Those are very good points. I find it very interesting that this particular composite measure, as opposed to the ACR, does identify a certain amount of disease. But psoriatic disease is difficult because there are many domains. Its not so easy to incorporate all these things into 1 overall grouping. Its a fairly reasonable attempt, and perhaps over time well use it more and more.

This transcript has been edited for clarity.

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Measuring Outcomes for the Treatment of Psoriatic Arthritis - MD Magazine

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