Monthly Archives: February 2022

Serotiny and Tessera Therapeutics enter into collaboration to engineer and optimize programmable Gene Writer proteins – Business Wire

Posted: February 28, 2022 at 7:56 pm

SAN FRANCISCO--(BUSINESS WIRE)--Serotiny, a leader in high-throughput therapeutic Multi-Domain Protein (tMDP) engineering, and Tessera Therapeutics, a biotechnology company pioneering a new approach in genetic medicines known as Gene Writing technology, today announced a collaboration to engineer programmable Gene Writer proteins. This collaboration will build on Tesseras innovations in genome engineering technologies and apply Serotinys tMDP mining and design expertise to further optimize Tesseras programmable Gene Writer proteins, capable of making diverse and directed alterations to the genome.

Were extremely excited to be working with the Tessera team, said Colin Farlow, J.D., Serotinys CEO. It provides Serotiny a unique opportunity to extend the validation of our platform and to continue to advance our efforts in discovering and developing proteins with novel function for the purpose of enhancing the therapeutic utility of next-generation genetic medicines.

Tesseras Gene Writer candidates can allow the substitution, insertion, or deletion of DNA sequences, as well as the writing of entire genes into the genome, offering the potential for a new category of genetic medicines. By partnering with Serotiny, Tessera will have the ability to identify, screen, and optimize a variety of proteins that can serve as the foundation of future Gene Writer therapies across a variety of disease states.

Tesseras mission is to cure disease by writing in the code of life and were committed to continuously innovating to improve and expand our Gene Writing platform, said Geoffrey von Maltzahn, PhD, co-founder and CEO of Tessera. Our R&D engine seeks to learn from billions of years of mobile genetic element evolution to generate novel Gene Writing systems with the ability to solve important challenges in genetic medicine. Serotinys multi-domain engineering expertise has the potential to further optimize our Gene Writer protein libraries and were delighted to partner with the Serotiny team.

Under terms of the agreement Serotiny will receive an upfront payment and is eligible for certain future consideration, contingent upon the collaboration achieving pre-specified performance thresholds.

About Serotiny

Serotiny is a pre-clinical discovery company building better gene and cell therapies through high-throughput engineering of therapeutic Multi-Domain Proteins (tMDP) such as Chimeric Antigen Receptors (CARs), CAR alternatives, accessory proteins, and next generation gene editors. At the heart of Serotinys technology is a discovery platform that harmonizes computationally aided protein design, high-throughput cellular assays, and next generation sequencing. Serotinys platform enables a cross disciplinary approach to engineering large and often unstructured multi-domain proteins, applying expertise from synthetic biology, immunology, machine learning, software engineering and bioinformatics. For more info visit http://www.serotiny.bio, or contact Colin Farlow at info@serotiny.bio.

About Tesseras Gene Writer platform

Tesseras Gene Writer proteins are based on natures genome architects, Mobile Genetic Elements (MGEs)the most abundant class of genes across the tree of life, representing approximately half of the human genome. Tessera has evaluated tens of thousands of natural and synthetic MGEs to create Gene Writer candidates in multiple categories including:

Tesseras research engine further optimizes the discovered Gene Writer candidates for efficiency, specificity, and fidelityessentially compressing eons of evolution into a few months.

About Tessera Therapeutics

Tessera Therapeutics is pioneering Gene Writing technology, which consists of multiple technology platforms designed to offer scientists and clinicians the ability to write therapeutic messages into the human genome, thereby curing diseases at their source. The Gene Writing platform allows the correction of single nucleotides, the deletion or insertion of short sequences of DNA, and the writing of entire genes into the genome, offering the potential for a new category of genetic medicines with broad applications both in vivo and ex vivo. Tessera Therapeutics was founded by Flagship Pioneering, a life sciences enterprise that conceives, resources, and develops first-in-category bioplatform companies to transform human health and sustainability. For more information about Tessera, please visit http://www.tesseratherapeutics.com.

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Serotiny and Tessera Therapeutics enter into collaboration to engineer and optimize programmable Gene Writer proteins - Business Wire

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Kelly Ketterson joins Genomic Prediction Team as Chief Operating Officer – PRNewswire

Posted: at 7:56 pm

Ketterson was trained and worked under the direction of Dr. Jacques Cohen and Dr. Mina Aliknai from 1996-2004 at The Institute for Reproductive Medicine and Science at Saint Barnabas Medical Center and alongside Dr. Santiago Munn in the development of embryo biopsy and PGT as a reference laboratory test.She is a highly experienced clinical embryologist specializing in embryo biopsy techniques, routine IVF procedures, quality control, clinical research trials and laboratory operations.

"I have had an incredible career and I thought it could not get any better until I received Dr. Treff's call asking me to join his team at Genomic Prediction," said Ketterson."Everything about my position on this team, their passion to improve reproductive genetic care for IVF patients and the warm welcome I have received is positioned to be the highlight of my tenure in reproductive health."

Ketterson has also served as the Executive Director for several educational conferences specializing in the continuing education of reproductive endocrinologists, IVF nurses, embryologists, andrologists and administrative staff. She has traveled throughout the world performing embryo biopsy procedures, improving laboratory standards and teaching micromanipulation techniques.

Prior to her role with Genomic Prediction and Cooper Surgical, Ketterson was the Chief Operating Officer Reprogenetics, Executive Director of Tyho-Galileo Research Laboratories and Althea Science.She has also completed the Master's Program in Biomedical Science at the Jones Institute at Eastern Virginia Medical School in Norfolk, Virginia.

Ketterson is passionate about the IVF field and her experience includes R&D in the area of IVF products and services, co-founding companies in the genomics space as well as development of web applications to improve the quality control in the IVF laboratory. She regularly participates with RESOLVE in their annual events to bring an understanding of infertility, IVF procedures and access to care for patients needing IVF services. Ketterson has served on both the ASRM exhibitor committee and the ESHRE genomics working group.

"We are so pleased that Kelly is joining our team," said Chief Science Officer and co-founder of Genomic Prediction, Dr. Nathan Treff. "Her years of experience combined with her real passion for improving the industry on behalf of patients is second to none."

Genomic Prediction CEO, Laurent Christian Asker Melchior Tellier echoed Treff's sentiment saying "a true pro, we are thrilled that Kelly brings her collaborative spirit and deep knowledge to the Genomic Prediction family."

About Genomic Prediction

Genomic Prediction is redefining human embryo genetic testing through ultra high resolution genetic reports so that, for the first time in human history, prospective parents can protect their future children from inheriting a predisposition to the most common diseases. Genomic Prediction's LifeView testing platform screens for diseases such as diabetes, heart disease, schizophrenia, and common cancers. We provide parents undergoing In Vitro Fertility treatments (IVF) with the means to reduce the risk to their embryos of chromosomal abnormalities, and other heritable diseases. Backed by rigorous preclinical validation and a unique interdisciplinary approach that combines years of experience in molecular genetics and computational biology, LifeView provides a one-of-a-kind machine learning based prediction of genetic abnormalities. Learn more about Genomic Prediction's LifeView testing at http://www.lifeview.com

Media contact: Elizabeth CarrCommunications Director, Genomic Prediction[emailprotected] 617.791.0163.

SOURCE Genomic Prediction

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Kelly Ketterson joins Genomic Prediction Team as Chief Operating Officer - PRNewswire

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The return of the revenge of COVID-19 mRNA vaccines permanently alter your DNA and lab leak – Science Based Medicine

Posted: at 7:56 pm

As repetitive as I have been with respect to this, there is nothing new under the sun when it comes to antivaccine myths, misinformation, and disinformation, and that applies to COVID-19 vaccines. If public health officials and messengers had paid more attention to the tactics and tropes of the antivaccine movement, including its central conspiracy theory, maybe they would have been more prepared for the onslaught of antivaccine misinformation that was unleashed as the mRNA COVID-19 vaccines were undergoing clinical trials and when they were finally initially approved under an emergency use authorization (EUA) near the end of 2020. They didnt, and here we are, which is why, having seen it before multiple times last year, Im faced with the return of the revenge of the antivaccine lie that mRNA-based COVID-19 vaccines permanently alter your DNA (they dont, nor do they hack the software of life, nor are they really gene therapy) this time from Jessica Rose, who is affiliated with James Lyons-Weilers antivaccine institute with the humble name of Institute for Pure and Applied Knowledge (IPAK). Unfortunately, Saturday I saw this zombie lie resurrected yet again in the form of an article on Substack (where the cranks whove been banned from Twitter, Facebook, YouTube, etc. all go) by Rose titled It does incorporate into human DNA. And its probably messing up embryogenesis, subtitled, These injectable convid-1984 products are perfect bioweaponseither by design or accident. Who cares which. The outcome is the same.

Once more unto the breach, I guess! I suppose that while Im here I should link to the two studies published last week and cited by Rose in her Substack to support her nonsensical claims that (1) the finding of a short nucleotide sequence in the spike protein mRNA sequence used in the Moderna vaccine is slam dunk evidence that SARS-CoV-2 was engineered and that the lab leak hypothesis for SARS-CoV-2 is true and (2) that SARS-CoV-2 permanently alters your DNA by being reverse transcribed and integrated into the DNA in its recipients chromosomes. Lets just say that neither Roses cited study from Lund University in Sweden about the supposed reverse transcription of the Pfizer/BioNTech mRNA-based vaccine into the DNA of human cells nor the study by Ambati et al about MSH3 homology support these hysterical claims.

Before I proceed, lets just reiterate that the idea that vaccines can permanently alter your DNA is not new to mRNA-based COVID-19 vaccines, although the nature of these vaccines makes that claim easier for antivaxxers to sell as plausible to those not familiar with molecular biology. Indeed, if you really look carefully at it, the claim that vaccines somehow changes your DNA actually dates back to before scientists even understood DNA as the basis of heredity, as illustrated, for example, by this famous Cow-Pock cartoon from 1802 by satirist James Gillray about smallpox vaccine:

Even a few years after Edward Jenner introduced the smallpox vaccine, the idea that vaccines somehow permanently alter humans had begun. (Source: Wikipedia and the Library of Congress, Prints & Photographs Division, LC-USZC4-3147, color film copy transparency.)

Savvy readers will notice how much a meme that was going around a year or so ago about the mRNA vaccines is very much of a piece with this 220-year-old cartoon:

How is this any different from 19th century antivax cartoons?

Similarly, the idea that an engineered virus, whether intentionally released or accidentally leaked from a laboratory, caused the pandemic is the same conspiracy theory that arises during every epidemic and pandemic, from various influenza pandemics to AIDS to Ebola. Of course, in the age of sophisticated molecular biology and genetics, antivaxxers can always find a special case that seems to show that the impossible is actually possible, and Jessica Rose is just continuing in this antivax tradition of misusing science, as Ill try to explain.

Before I discuss the two studies and the claims being made about them not just by Jessica Rose but by a number of antivaxxers, lets take a look at some basic biology and molecular biology, so that you understand why her claims are so beyond the ken. I realize that Ive done this before, but its been a while; so instead of just including links to my previous discussions, Ill include a brief explanation of something out of Biology 101, so that were all on the same page. If you know all of this, you can probably skip to the next section. If not, lets proceed.

mRNA vaccines rely on the central dogma of molecular biology. As Ive said many times before, Ive always hated the use of the word dogma associated with science, but no less a luminary than Francis Crick first stated it in 1958, and it has been restated over the years in various ways. Perhaps my favorite version of the central dogma was succinctly stated by Marshall Nirenberg in 1958 and has since been commonly paraphrased to say, DNA makes RNA makes protein, which about summed up all of molecular biology in five words. (Why I used the past tense in a moment.) In any event, for purposes of understanding the very basics of RNA vaccines, this is the main sequence that you need to understand.

Its true, of course, that DNA replicates from a DNA template and results in a double-stranded molecule that is very stable, as it has complementary sequences that tightly bind to each other in a sequence-specific fashion. This DNA template is unwound by enzymes that use the template to make RNA, which is single-stranded. That RNAwhen used to code for a protein called a messenger RNA or mRNAis then used by a ribosome to make protein out of amino acids. Again, to put it simply, each nucleotide equals one letter of the code; each three-nucleotide sequence (codon) equals one word that translates to an amino acid. Given that there are four nucleotides, there are 64 possible codons. Since there are only 20 amino acids, that means that most amino acids are encoded by more than one combination of nucleotides or more than one codon; i.e., the genetic code is redundant. Of course, as is the case with nearly everything in biology, its more complicated than that, as these diagrams show:

The Central Dogma of Molecular Biology. Information flows from DNA to RNA and then is used to make protein.

Information flows from DNA in the nucleus, to RNA, which is transported into the cytoplasm and used as a template to make protein.

There are more complications to this seemingly simple scheme, of course. mRNA doesnt always start out fully formed. Often its made as a longer precursor molecule, parts of which are spliced out by enzymes, to produce the final mRNA sequence before the mRNA molecule is used as a template to make protein. There are also other complexities that go beyond the central dogma, such as retroviruses, which make DNA using RNA templates, and microRNA, which can regulate gene expression by binding to specific sequences on mRNAs and blocking transcription and/or inducing the breakdown of the mRNA molecule, for instance. You dont really need to know the gory details of these processes or others, though, except retroviruses, whose ability to reverse the flow of information, so to speak, by transcribing DNA off of an RNA template using an enzyme known as reverse transcriptase will be very relevant to the discussion of the Swedish paper. HIV is the retrovirus that is the most well-known because of its ability to cause AIDS.

Exceptions aside, RNA vaccines consist mainly of, well, RNA. One problem with RNA vaccines is that RNA is an inherently unstable molecule. It is, after all, a messenger. It doesnt need to persist any longer than the message needs to be made. In aqueous solution, RNA molecules rapidly degrade. Indeed, the instability of RNA is why public health experts have been concerned about distributing RNA vaccines. Both Pfizer/BioNTech and Moderna adopted a similar strategy in designing their mRNA to encode the SARS-CoV-2 spike protein with stabilizing mutations added to lock this surface protein into a form easily recognizable to the immune system and therefore make it a better antigen. Pfizer and Moderna also used modified nucleosides (the RNA equivalent to DNA nucleotides) that are more stable to make their RNAs, and placed their RNA within a lipid nanoparticle (LNP) delivery system in which LNPs fuse with the cell membrane to deliver the RNA to the cytoplasm.

Naked mRNA of kind used in the Pfizer/BioNTech and Moderna vaccines rely on a very simple mechanism in which the LNPs deliver the mRNA for the SARS-CoV-2 spike protein to muscle cells, which then use the mRNA as a template to make spike, which is then displayed on the surface of the cell to be recognized by the immune system. Some of the vaccine does manage to get to the regional lymph nodes, where they incite an immune reaction as well. This is part of the reason why COVID-19 vaccines have been found to produce false positives in mammography done too soon after vaccination by causing temporary enlargement of the lymph nodes under the arm, which is why mammography recommendations have changed to incorporate waiting at least six weeks after receiving an intramuscular COVID-19 vaccine in the deltoid muscle before undergoing screening mammography.

Before I go on, let me emphasize that, even though SARS-CoV-2 is an RNA virus, it is not the same thing as a retrovirus and the mRNA in LNPs is not the same thing as RNA in retroviruses. Whereas SARS-CoV-2, like most RNA-based viruses, uses an enzyme called an RNA-dependent RNA polymerase (RdRp) to make copies of its RNA genome from an RNA template, retroviruses use an enzyme called reverse transcriptase to produce a DNA copy of their genetic information, which can then integrate into the human genome. Thats why, in order to produce a suitably fear-mongering narrative, antivaxxers usually have to look very hard for highly unusual, artificial, or special case experiments. Guess what? Rose found them.

So lets see what Jessica Rose wrote about these studies. Her message is, unsurprisingly, very much like that of antivaxxers 220 years ago:

I started to write this article yesterday but not one, but two papers of great interest to me have been published recently and require dissection and dissemination. They are entitled: MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site and Intracellular Reverse Transcription of Pfizer BioNTech COVID-19 mRNA Vaccine BNT162b2 In Vitro in Human Liver Cell Line, respectively.

Let me be clear here: These COVID-19 injectable products are perfect bioweapons either by design or accident. Who cares which. The outcome is the same.

Regarding the first paper, Rose writes:

Background for future: MSH3 (MutS Homolog 3) is gene that encodes a protein that is responsible for maintaining the stability of our genomes and suppressing tumor formation. This protein is DNA mismatch repair (MMR) protein which means that it recognizes and repairs bad base (nucleotide) insertions, deletions and mis-incorporations that come about inherently as part of DNA recombination and replication as well as DNA repair. You might have heard me talk about this in some of my presentations in reference to the recently-published paper describing 2 enzymes characterized to be inhibited by the spike protein.

we found that the spike protein localizes in the nucleus and inhibits DNA damage repair by impeding key DNA repair protein BRCA1 and 53BP1 recruitment to the damage site.

This more recent paper shows the presence of a 19 nucleotide-long sequence (19mer) that in fact, contains the sequence that encodes the furin-cleavage site of the SARS-nCoV-2 spike protein. In other fact, this 19mer has 100% sequence identity (100% query cover and matched identity anti-parallel complementarity 5-3) with patented sequences from as early as 2015. (I am checking on the link to MSH3.)

Aha! Theres the conspiracy theory! (More on that later.) First, though, Ill just note that this is far from the first time that Ive seen the claim that COVID-19 vaccines somehow interfere with DNA repair. Last time around, it was the claim that the vaccine somehow interferes with a process known as non-homologous end joining (NHEJ) and thereby make those receiving it much more susceptible to cancer. That claim was deceptive. Indeed, the study was very poor quality and had no biological relevance to human cancer risk, although it did contribute to the fascist antivax claim that vaccines somehow pollute the blood, making the unvaccinated purebloods. Unsurprisingly, its exactly the paper Rose cited.

As for the second study, Rose is no lessoff base:

Perhaps even more disturbing from a biological point of view, is something that many of us have hypothesized to be possible, has now been proven to be the case. Another new paper (link above) confirms that the Pfizer mRNA incorporates into human DNA. IN AS LITTLE AS 6 HOURS.

We detected high levels of BNT162b2 in Huh7 cells and changes in gene expression of long interspersed nuclear element-1 (LINE-1), which is an endogenous reverse transcriptase.

Huh is right.

Huh cells are immortal liver tumor cells and grow ad-infinitum if you give them love. They are good for using in assays that involve viral propagation. LINE-1 is a reverse transcriptase that we carry and comprises ~17% of our genome! LINE-1 retrotransposons are necessarily active during embryogenesis are aberrantly active in tumorigenesis.

This claim, as has often been the case, rests on a kind of experiment thats been done a number of times before to try to prove that the RNA virus SARS-CoV-2 can somehow mimic a retrovirus and insert its genetic sequence into the human genome, just like HIV. Thats why Ill discuss this study first.

Before I discuss this study, lets just reiterate that, for all the caveats and exceptions to the central dogma of molecular biology, for the vast majority of cases in normal mammalian cellular biology, information does not flow backwards from RNA to DNA. One of those exceptions, HIV and other retroviruses, requires two different enzymes to accomplish this backwards flow of genetic information. The first is the aforementioned reverse transcriptase, which reverse transcribes RNA sequences into DNA, destroying the RNA template in the process. However, that is not enough, as reverse transcriptase does not integrate the DNA strands thus produced into the human genome. A second enzyme is needed, a retroviral integrase. Integrases insert the double-stranded DNA produced by reverse transcriptase into the hosts chromosomal DNA; you can view this as a point of no return, after which the viral DNA becomes part of the host DNA, a form in which it is called a provirus, and a property of retroviruses that allow them to persist for so long in their hosts.

Retroviruses are not the only source of reverse transcriptase, as noted by Jessica Rose. Mammalian cells have very low levels of reverse transcriptase activity, so low that theyre usually not detectable under normal circumstances. One source is telomerase, which adds sequences known as telomere repeat sequences to the ends of chromosomes using an RNA template, to forestall the obligate chromosome shortening that occurs with each round of cellular replication. (Excessive telomerase activity is associated with the unlimited replicative potential of cancer.) Then there is LINE-1, mentioned by Rose and the focus of the paper.

LINE stands for long interspersed nuclear elements (LINEs). They are what are known as retrotransposons, also known as class 1 transposable elements or transposons via RNA intermediaries. Basically, retrotranposons can copy and paste themselves into different locations in the genome by making RNA and converting that RNA back into DNA through reverse transcription. Because its simple, Ill borrow an illustration of how they work from Wikipedia:

How retrotransposons copy and paste themselves into different locations in the genome.

You might reasonably be wondering at this point what LINE-1 could have to do with genetic sequences from the vaccine somehow getting into the human genome, thereby permanently altering your DNA. Youd be correct to wonder and likely would wonder even more if I told you that most LINEs in our genome are inactive and dont make any functional enzyme and that they greatly prefer their own RNA and dont randomly reverse transcribe just any old RNA. After all, retrotransposition (the process) requires that retrotransposons be able to replicate themselves and then paste the new copies elsewhere in the genome. It doesnt matter that, as Rose points out, LINE-1 does make up approximately 17% of the human genome. Very little of it is active in normal physiology, although increased LINE-1 is associated with cancer, neuropsychiatric disorders, and retinal diseases. (I almost hated to say that because it gives antivaxxers ideas.)

So what does the second study cited by Rose claim? What did the investigators do? First, lets look at the investigators rationale:

A recent study showed that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the genome of human cells [25]. This gives rise to the question of if this may also occur with BNT162b2, which encodes partial SARS-CoV-2 RNA. In pharmacokinetics data provided by Pfizer to European Medicines Agency (EMA), BNT162b2 biodistribution was studied in mice and rats by intra-muscular injection with radiolabeled LNP and luciferase modRNA. Radioactivity was detected in most tissues from the first time point (0.25 h), and results showed that the injection site and the liver were the major sites of distribution, with maximum concentrations observed at 848 h post-dose [26]. Furthermore, in animals that received the BNT162b2 injection, reversible hepatic effects were observed, including enlarged liver, vacuolation, increased gamma glutamyl transferase (GT) levels, and increased levels of aspartate transaminase (AST) and alkaline phosphatase (ALP) [26]. Transient hepatic effects induced by LNP delivery systems have been reported previously [27,28,29,30], nevertheless, it has also been shown that the empty LNP without modRNA alone does not introduce any significant liver injury [27]. Therefore, in this study, we aim to examine the effect of BNT162b2 on a human liver cell line in vitro and investigate if BNT162b2 can be reverse transcribed into DNA through endogenous mechanisms.

This is thin gruel as a rationale. I note that Ive discussed the cited study before, which involved the intravenous injection of a large amount of LNPs with a different mRNA than the vaccines spike protein mRNA, again an artificial design intended to make determination of the biodistribution of the LNPs possible given that in an intramuscular injection the vast majority of the mRNA remained at the injection site and in nearby lymph nodes.

I also note that it is not a new claim that SARS-CoV-2 itself is reverse transcribed in the infected cell to integrate with the host genome. This is a study from last summer that antivaxxers previously used to claim that, based on the supposed ability of SARS-CoV-2 to reverse transcribe, the vaccine could do the same. Lets just say that this study was justifiably harshly criticized as not reproducible, very rare, and almost certainly artifacts of the experimental conditions used, given that appropriate controls werent used. To cite Ed Nirenberg again, no, SARS-CoV-2 is not reverse-transcribed to any significant extent, the publication of the study in PNAS notwithstanding.

I get the same vibes from this new study. So what did the authors do? They did indeed take Huh7 liver cells and expose them to the Pfizer/BioNTech vaccine (BNT162b2), at 200,000 cells/well in 24-well plates. Then they did this:

BNT162b2 suspension was then added in cell culture media to reach final concentrations of 0.5, 1.0, or 2.0 g/mL. Huh7 cells were incubated with or without BNT162b2 for 6, 24, and 48 h. Cells were washed thoroughly with PBS and harvested by trypsinization and stored in 80 C until further use.

After 48 hours, the cells were harvested. RNA was extracted for PCR, and in other experiments genomic DNA was extracted from the cells. Of particular importance however, is that the segment of the nucleic acid for the spike protein that was amplified by PCR was this:

Spike amplicon, specifically the part of the sequence amplified by PCR in this experiment.

Why did they pick primers that amplified only this segment of the gene for spike protein? PCR efficiency drops off the longer the segment that is amplified, and a 444 base segment is actually rather long for quantitative real time PCR. In any event, this choice means that the only thing that can be said is that perhaps this segment of spike was reverse transcribed. Another thing to note is that a very high concentration of vaccine was used, microgram quantities for only 200,000 cells. That in and of itself is very artificial, but thats not all thats artificial. As Ed Nirenberg points out, Huh7 was derived from a liver cancer. Unsurprisingly, the Huh7 genome is, as is the case with many cancer-derived cell lines, really messed up.

He also notes that L-1 expression is substantially overexpressed in cancer (i.e., cancer cells have a lot more of it than normal cells).

In other words, the investigators stacked the deck by using a cell line that has a high level of LINE-1. If I were a peer reviewer for this study, I would have demanded that the investigators use a more genomically normal cell line. No cell line that is immortalcan propagate indefinitelyhas a normal genome, but some have genomes that are less messed up than others. There are a number of respiratory cell lines, for instance, that could work, or what about simple primary cultures of vascular endothelial cells, such as HUVECs (human umbilical vein endothelial cells)? Why did they use only one cell line? In general, if you see a paper that uses only one cell line, be very, very skeptical, not just for COVID-19 but for any basic science studies.

So back to the paper. What did the authors find? Yes, they found that the vaccine, as expected, drove spike mRNA expression, leading to high levels in the cells, while not having much effect on LINE-1 expression, concluding that increased LINE-1 expression compared to control was observed at 6 h by 2.0 g/mL BNT162b2, while lower BNT162b2 concentrations decreased LINE-1 expression at all time points. If you look at the figure, I call noise, because it doesnt make a lot of physiologic sense that the lower vaccine concentrations would depress LINE-1 expression but lead to increased expression only at the 6 hour time point.

Whenever you see a graph like this, get out your BS detector.

Hilariously, this chart is the very same one included in Roses article, but she fails to see its shortcoming. Amusingly, the authors used two-tailed Students t-tests to compare these differences, which is not the correct statistical test for multiple time-dependent comparisons, and the finding of this result is most consistent with noise. Had I been a peer reviewer, I would definitely have called out the statistics used.

But what about reverse-transcribed DNA for spike? Yes, the authors did detect that in the genomic DNA isolated from the cells. They even sequenced the amplified segment and found that it was the same spike sequence targeted by the PCR primers. Checkmate, scientists! Not quite, and the authors even add some weasel words:

In this study we present evidence that COVID-19 mRNA vaccine BNT162b2 is able to enter the human liver cell line Huh7 in vitro. BNT162b2 mRNA is reverse transcribed intracellularly into DNA as fast as 6 h after BNT162b2 exposure. A possible mechanism for reverse transcription is through endogenous reverse transcriptase LINE-1, and the nucleus protein distribution of LINE-1 is elevated by BNT162b2.

Note that this study most definitely did not show that this reverse transcription had anything to do with LINE-1, leaving the authors to speculate. They could have presented evidence that LINE-1 was responsible, perhaps by knocking it out to produce cells that dont make it or using siRNA that targets the LINE-1 mRNA to decrease its level, and showing that that it blocked the reverse transcription of spike. They didnt do that. So they speculate, and antivaxxers ignore that this is speculation to present it as a fact that SARS-CoV-2 is reverse transcribed through the reverse transcriptase activity of LINE-1.

Next:

Our study shows that BNT162b2 can be reverse transcribed to DNA in liver cell line Huh7, and this may give rise to the concern if BNT162b2-derived DNA may be integrated into the host genome and affect the integrity of genomic DNA, which may potentially mediate genotoxic side effects. At this stage, we do not know if DNA reverse transcribed from BNT162b2 is integrated into the cell genome. Further studies are needed to demonstrate the effect of BNT162b2 on genomic integrity, including whole genome sequencing of cells exposed to BNT162b2, as well as tissues from human subjects who received BNT162b2 vaccination.

This led to some epic handwaving:

The cell model that we used in this study is a carcinoma cell line, with active DNA replication which differs from non-dividing somatic cells. It has also been shown that Huh7 cells display significant different gene and protein expression including upregulated proteins involved in RNA metabolism [56]. However, cell proliferation is also active in several human tissues such as the bone marrow or basal layers of epithelia as well as during embryogenesis, and it is therefore necessary to examine the effect of BNT162b2 on genomic integrity under such conditions. Furthermore, effective retrotransposition of LINE-1 has also been reported in non-dividing and terminally differentiated cells, such as human neurons [57,58].

Sure thing, guys, but no. This is, as I said, just handwaving.

As Ed Nirenberg asks, why didnt they bother to do the necessary follow-up experiments to determine if this DNA sequence is actually integrated into the genome? Come to think of it, why didnt they do PCR of the entire spike sequence to show that the full length sequence had been reverse-transcribed? Or even just do PCR of different fragments from the spike sequence? It boggles the mind.

None of this stops Rose from going straight off the end of the plank of science to this conclusion:

LINE-1 retrotransposons are also involved during early embryonic development. Since LINE-1 expression levels are significantly increased then what effect is this over-expression having on embryogenesis?

We found that too much or too little LINE-1 expression caused development to come to a halt. This means that the precise timing and level of retrotransposon expression is critical for the development of the embryo.

I need a walk. This article will be updated.

I can hardly wait for Roses updates, given how far she had to reach to find some rationale to take a highly artificial experiment that almost certainly doesnt show that the mRNA for the SARS-CoV-2 spike used in COVID-19 vaccines is reverse transcribed under normal conditions, much less integrated into the genome of the cells in which it finds itself. Im guessing that her updates will be as hilariously off base as her original post.

But what about the first study?

The second paper cited by Rose turns out to be all about the lab leak conspiracy theories. Its not about the more plausible variant of the lab leak concept (but still highly unlikely compared to a natural origin) in which a naturally occurring bat coronavirus somehow escaped the virology lab at Wuhan, thereby starting the pandemic, but rather the utter bonkers idea that SARS-CoV-2 is an engineered coronavirus that escaped the laboratory, thanks to gain of function research. Of course this version is a different twist on the same idea, specifically that the finding of a short DNA sequence from a larger sequence patented by Moderna years ago as part of its cancer research effort in the sequence in the spike protein mRNA used in the Moderna vaccine is slam-dunk evidence for the lab leak hypothesis. Lets just say that its not.

The article is a perspective article, which means its basically the peer-reviewed scientific equivalent of an op-ed article. I also cant help but wonder how the authors got something like this published on the basis of doing some BLAST searches of the Genbank database, something basically anyone with an Internet connection can do to see if nucleotide and protein sequences exist in all the ones reported to the database. I used to do BLAST searches all the time, and have even done a few going way, way back to the beginning of the pandemic, when James Lyons-Weiler tried to prove that there were sequences from a common plasmid in SARS-CoV-2, thus demonstrating that it was engineered. (Hint: He failed.)

The op-ed asserts:

A peculiar feature of the nucleotide sequence encoding the PRRA furin cleavage site in the SARS-CoV-2 S protein is its two consecutive CGG codons. This arginine codon is rare in coronaviruses: relative synonymous codon usage (RSCU) of CGG in pangolin CoV is 0, in bat CoV 0.08, in SARS-CoV 0.19, in MERS-CoV 0.25, and in SARS-CoV-2 0.299 (9).

A BLAST search for the 12-nucleotide insertion led us to a 100% reverse match in a proprietary sequence (SEQ ID11652, nt 2751-2733) found in the US patent 9,587,003 filed on Feb. 4, 2016 (10) (Figure 1). Examination of SEQ ID11652 revealed that the match extends beyond the 12-nucleotide insertion to a 19-nucleotide sequence: 5-CTACGTGCCCGCCGAGGAG-3 (nt 2733-2751 of SEQ ID11652), such that the resulting mRNA would have 3- GAUGCACGGGCGGCUCCUC-5, or equivalently 5- CU CCU CGG CGG GCA CGU AG-3 (nucleotides 23547-23565 in the SARS-CoV-2 genome, in which the four bold codons yield PRRA, amino acids 681684 of its spike protein). This is very rare in the NCBI BLAST database.

The correlation between this SARS-CoV-2 sequence and the reverse complement of a proprietary mRNA sequence is of uncertain origin. Conventional biostatistical analysis indicates that the probability of this sequence randomly being present in a 30,000-nucleotide viral genome is 3.21 1011 (Figure 2).

Wow. That sounds damning, doesnt it?

Of course, those following various lab leak hypotheses for the origin of SARs-CoV-2 will immediately recognize the reference to the furin cleavage site. An interesting feature of the SARS-CoV-2 spike protein is that it consists of two subunits and, between those two subunits, S1 and S2, sits a site where a human protein called furin cleaves the protein, resulting in the two functional subunits. In fact, you might even recognize the claim that the two successive CGG codons, coding for two arginine residues in the furin cleavage site, is a rare codon usage. Lets just say that, in terms of the pandemic, this is a hoary old bit of SARS-CoV-2 conspiracy mongering dating back to very early in the pandemic and popularized by science writer-turned-COVID-19-conspiracy theorist Nicholas Wade. Moreover, the term randomly present in a 30 kb viral genome is doing a lot of heavy lifting, mainly because no one is saying that its random. Do the authors think that beta coronaviruses (of which SARS-CoV-2 is one) are made up of random sequences unrelated to each other? Of course not! Theyre highly related.

Indeed, it has been pointed out just how off-base the probability argument is:

Lawrence Young, Ph.D., a virologist at the University of Warwick, said it was interesting but probably not significant enough to suggest the virus was manipulated in a laboratory. Were talking about a very, very, very small piece made up of 19 nucleotides. So it doesnt mean very much to be frank, if you do these types of searches you can always find matches. Sometimes these things happen fortuitously, sometimes its the result of convergent evolution (when organisms evolve independently to have similar traits to adapt to their environment). Its a quirky observation but I wouldnt call it a smoking gun because its too small. It doesnt get us any further with the debate about whether COVID was engineered.

Simon Clarke, Ph.D., a microbiologist at Reading University, also questioned the one-in-three trillion statistics, saying, There can only be a certain number of [genetic combinations within] furin cleavage sites. They function like a lock and key in the cell, and the two only fit together in a limited number of combinations. So its an interesting coincidence but this is surely entirely coincidental.

If youre a conspiracy theorist, of course, there is no such thing as a coincidence, at least if its about something you want to believe to be true. In any event, this is exactly correct. The wrong argument to make is how common such a 19 nucleotide sequence would occur randomly in a viral genome. You have to take into account function, which greatly constrains the sequences one can find, plus how short this sequence is, which makes it very much more likely that it did indeed occur by chance.

As Ive discussed before, it turns out that a CGGCGG sequence is not all that uncommon. It has been found in other coronaviruses, for example, some isolates of MERS coronavirus. Furin cleavage sites are also found in a number of other coronaviruses, as discussed in this recent review article. Although uncommon, furin cleavage sites are not so uncommon in coronaviruses as to be any sort of strong evidence of laboratory manipulation. Moreover, there are known natural mechanisms by which such a sequence could have arisen, as has been discussed extensively on Twitter and elsewhere. But what about that 19-nucleotide sequence?

I will note, however, that the claim made in this op-ed is a rather interesting spin on the same old claims about the SARS-CoV-2 furin cleavage site in that I havent seen it before. In this case, the authors are claiming that this 19 nucleotide sequence found in MSH3, a DNA repair gene, is the very same sequence patented by Moderna seven years ago and found in the furin cleavage site of the spike sequence used in the Moderna vaccine, with the implication that SARS-CoV-2 was engineered:

The proprietary sequence SEQ ID11652, read in the forward direction, encodes a 100% amino acid match to the human mut S homolog 3 (MSH3) (9). MSH3 is a DNA mismatch repair protein (part of the MutS beta complex) (11). SEQ ID11652 is transcribed to a MSH3 mRNA that appears to be codon optimized for humans (12). We did not find the 19-nucleotide sequence CTCCTCGGCGGGCACGTAG in any eukaryotic or viral genomes except SARS-CoV-2 with 100% coverage and identity in the BLAST database (Supplementary Tables 13).

A claim that the authors make explicit:

The absence of CTCCTCGGCGGGCACGTAG from any eukaryotic or viral genome in the BLAST database makes recombination in an intermediate host an unlikely explanation for its presence in SARS-CoV-2.

Ergo, this sequence must have been engineered. Add to that the Moderna patent and checkmate, right? Not so much. For one thing, this sequence is the reverse complement of the sequence found on the furin cleavage site. What does that mean? Its on the opposite strand, the strand that doesnt code for protein. The authors do a lot of handwaving to try to explain this, mainly by claiming that cells co-transfected with a SARS-like virus expressing RdRp could attach to this 19-nucleotide sequence (15) and permit integration of a fragment from the negative strand into the viral genome, including the FCS, despite being on the opposite strand of the open reading frame, RdRp being the RNAse-dependent RNA polymerase mentioned early in this post. Perhaps, but this comes across to me more as an attempt to wave away the very substantive criticism that a sequence that isnt the strand that codes for the actual protein.

Just for yucks, I did some BLAST searches myself, and after doing a number of them I concluded that this result was not easy to come by. I had to search the sequence patented by Moderna versus SARS-CoV-2 with the loosest parameters that allowed for the least degree of similarity; otherwise there were zero matches, largely because stricter parameters only find longer stretches of sequence similarity. Thats why I now rather suspect that the investigators searched the sequence for SARS-CoV-2 versus every sequence ever patented by Moderna, and the best they could come up with was this short 19 amino acid match, after which, even though it was the reverse complement and not even on the strand that codes for the protein, started searching other Moderna patents for the same 19mer and found a few more hits.

Making me even surer that this is random is Roses own further observations:

Most disturbing, however, is that HZ246785.1 was patented 7 years ago by MODERNA THERAPEUTICS (2015) and more recently by ModernaTX Inc (2017/2018). Other patents for this same 19mer were filed by CAMBIA (2015) and CureVac AG (2021). A shorter version with 89% query and 100% matched identity were found in patents filed by Monsanto Technology LLC (2016) and Metanomics GmbH (2015). Just noting some familiar names here. Not making any claims.

Then, thankfully, bioinformatician Moreno Colaiacovo provided a lengthy explanation dating back to December why theres nothing to see here; so Ill cite his brief discussion in its entirety:

When challenged, Colaiacovo noted:

And:

Think of it this way. Whoever initially found this 19 nucleotide sequence did a lot of work to find it. Yet, this is the best they could come up with as slam dunk evidence that SARS-CoV-2 was engineered by Moderna, to the point where they have to do serious contortions make such a short stretch seem nefarious? Another way to think of it is just how unlikely it is that this shared 19-mer is proof of some sort of engineering or that Moderna knew about SARS in 2016. Again think of how unlikely the implied necessary scenario would be: Somehow during an experiment cells transfected with the sequence in the patent were infected by a SARS-like virus, and then there was a recombination event that led to SARS-CoV-2 with a furin cleavage site containing that sequenceand not even on its coding strand, but on its reverse complement strand! This is reaching homeopathy-levels of implausibility.

As I like to say, in antivaxland, everything old is new again in the age of COVID-19. However, as the pandemic grinds on, entering its third year, even everything old that was new again when COVID-19 struck is becoming old. The idea that COVID-19 vaccines permanently alter your DNA has now spawned a number ofif youll excuse my use of the termvariants. So has the version of the lab leak hypothesis that asserts that SARS-CoV-2 was somehow engineered, this variant adding a conspiracy theory that implies that one of the manufacturers of the first successful COVID-19 vaccines must have somehow known the sequence of SARS-CoV-2 nearly four years before the pandemic. What Jessica Rose is promoting, aided and abetted by these awful studies published in bottom feeding journals, is simply helping to spread variants of these two conspiracy theories.

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Comprehensive Genomic Profiling: When to Retest Patients – AJMC.com Managed Markets Network

Posted: at 7:55 pm

Bruce Feinberg, DO: Mark, whats your delay? First, the way the it works at Memorial [Sloan Kettering Cancer Center], lets say theyve gone the surgical route. Are they coming to you with the full panel when you do your first evaluation? Are you ordering in most cases?

Mark G. Kris, MD: It depends on this evolving, and it depends on the nature of the biopsy material we have. This is going to send everybody off, but for thoracic cancers, we now have reflex NGS [next-generation sequencing] testing. At the time lung cancer is suspected, whether the biopsy is done by an interventional radiologist, a pulmonologist, or a thoracic surgeon, sufficient material is obtained for anatomic pathologyimmunohistochemistry tests that support the anatomic diagnosisand NGS.

Bruce Feinberg, DO: For our viewers, the concept of reflex testing is inherent to the understanding of the tumor. The pathologist looks at it, but also additional tests are performed. For breast cancer, this has been routine for decades because you cant say its cancer and adenocarcinoma, ductal adenocarcinoma. Youd have to understand that it has estrogen receptor, progesterone receptor, HER2 [human epidermal growth factor receptor 2] overexpression, etc. The reflex testing concept is to take it 1 step beyond. That is part of the pathologic diagnosis. The diagnosis isnt complete with that information. Thats fascinating. Kenna, is reflex testing done at [The University of Texas] MD Anderson [Cancer Center] yet?

Kenna R. Mills Shaw, PhD: Outside of breast cancer, no.

Bruce Feinberg, DO: Theres going to be a conversation tomorrow, or as soon as this airs, if Memorial is doing it and youre not.

Kenna R. Mills Shaw, PhD: But our clinicians order it. The reality is that we have so many patients who walk in the door with their commercial sequencing. I had a patient who came in with their MSK sequencing in hand. We dont rerun an assay thats already been run, frankly. If somebody walks in with an MSK test result, we dont think our assay is better than MSKs. We love MSK-IMPACT; we take it. We reinterpret it by our precision oncology decision-support team to get optimal trialsthat just-in-time response. But if a good NGS assay is done by a reputable group, we consider it equivalent, regardless of who did it. We do not do reflex for that reason.

Transcript edited for clarity.

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PBE: Neither Lucrative, Nor Competitive – Seeking Alpha

Posted: at 7:55 pm

Jordan Siemens/DigitalVision via Getty Images

Invesco Dynamic Biotechnology & Genome Portfolio ETF (NYSEARCA:PBE) is an exchange traded fund operated by Invesco Capital Management LLC. The fund invests in stocks of companies primarily in the biotechnology sector. The ETF has invested almost 36 percent in large cap and mid cap stocks, and approximately 28 percent in small cap stocks. It benchmarks itself with Dynamic Biotech & Genome Intellidex Index, by using full replication technique. This ETF was launched on June 23, 2005 and invests primarily in the US equity market (87.55 percent of its total portfolio). The ETF has a 60 month beta of 0.96.

As of Feb 25, 2022, the fund had significant holdings (3 percent and above of its total portfolio) in companies operating in the biotechnology, and life sciences tools & services sector, only exception being the pharmaceutical firm Catalent Inc. It had invested more than 72 percent of its total holdings only in 18 stocks. At that point the market price of PBE was 59.93.

Holdings

Source: Invesco | Holdings | Invesco Dynamic Biotechnology & Genome ETF

Invesco Dynamic Biotechnology & Genome Portfolio ETF is not meant for income seeking investors as it doesnt pay any dividend at present. Neither does it have any track record of paying dividends. Incorporated on June 23, 2005, it paid quarterly dividends only for 11 quarters, and special dividend in 1 quarter out of 66 quarters it has been in operation. So, this fund is outside the purview of income seeking investors. The investors have to rely only on the price growth of this ETF.

Dividend history

Source: Stock Picks, Stock Market Investing

So, the investment decision will solely depend upon the expected future performance of the fund over the long run. The fund has historically performed reasonably well, and generated a return quite close to S&P500TR. PBE has recorded a growth over 41 percent over the past 5 years, and can be considered a below average (but not a very bad) return. However, the last year has caused some real doubts in terms of its investability. The fund has dipped down by 20 percent or more, whereas the S&P500TR had grown over 20 percent, thus creating a gap of 40 percent within a year. While many ETFs have recorded negative returns in the last year, its rare to witness such a huge gap when we compare such funds to a similar type of S&P index.

On further analysis, I found that the major holdings (3 percent or above) of PBE have mostly generated negative returns over the past one year. 13 of the 18 stocks have recorded negative growth, ranging as low as negative 60 percent recorded by Emergent BioSolutions Inc. (NYSE:EBS). Only Regeneron Pharmaceuticals Inc. (NASDAQ:REGN), Bio-Techne Corporation (NASDAQ:TECH), Xenon Pharmaceuticals Inc. (NASDAQ:XENE), Alkermes plc (NASDAQ:ALKS), Ironwood Pharmaceuticals, Inc. (NASDAQ:IRWD), have generated positive returns in past one year.

Peers

Source: Invesco Dynamic Biotechnology & Genome Portfolio ETF (PBE) Stock Price Today, Quote & News

As my regular readers know, the past year has been bad for large cap (market capitalization over $12.9 billion) biotech firms, - Amgen Inc. (NASDAQ:AMGN), Moderna (NASDAQ:MRNA), Celgene Corporation (NASDAQ:CELG), Gilead Sciences, Inc. (NASDAQ:GILD), Regeneron Pharmaceuticals Inc., Horizon Therapeutics Plc (NASDAQ:HZNP), Vertex Pharmaceuticals Inc. (NASDAQ:VRTX), Illumina Inc. (NASDAQ:ILMN), Biogen Inc. (NASDAQ:BIIB), Seagen Inc. (NASDAQ:SGEN), Alnylam Pharmaceuticals Inc. (NASDAQ:ALNY), BioMarin Pharmaceutical Inc. (NASDAQ:BMRN), Incyte Corporation (NASDAQ:INCY), Viatris Inc. (NASDAQ:VTRS), 10x Genomics, Inc. (NASDAQ:TXG), - which had otherwise been sought after by the investors interested in healthcare stocks. Out of these 15 large cap stocks, only Regeneron Pharmaceuticals Inc. had been able to record double digit growth. Vertex Pharmaceuticals Inc. grew by 8.13 percent, and the remaining had a very poor year. PBE, perhaps had made the mistake of investing too much (36.27 percent) in large cap stocks.

Amgen Stock

Source: Amgen Inc. (AMGN) Stock Price Today, Quote & News

What is even more concerning is that this ETF is expected to drop further down. It is currently trading at 8 percent over its 52 week low. And the long term moving averages are placed above the short term moving averages, implying that the stock may possibly dip below its 52 week low. However, a course correction is very much possible too, if the biotechnology sector gets some positive boost or gets into a bull run. At present, it seems very unlikely.

PBE Technicals

Source: Invesco Dynamic Biotechnology & Genome Portfolio ETF (PBE) Momentum Performance

PBE has been in operation since the 2nd quarter of 2005, and over all these years, has recorded a growth of 300 percent. The growth surely looks impressive. However, two things we need to remember are - a) calculated from inception, there is always a high possibility of recording abnormal growth rate, which may come down drastically once the company enters maturity, and b) biotechnology sector witnessed considerable growth during this period. A better indicator will be to compare the growth rate of similar ETFs over the same long time horizon. I can think of three such ETFs - First Trust NYSE Arca Biotechnology Index Fund (NYSEARCA:FBT), SPDR S&P Biotech ETF (NYSEARCA:XBI), and ProShares Ultra Nasdaq Biotechnology (NASDAQ:BIB). I find that over the same time horizon, the growth rate of both BIB and FBT is twice that of Invesco Dynamic Biotechnology & Genome Portfolio ETF. Of course, these have different investment strategies, however the difference is still concerning.

Peers

Source: Invesco Dynamic Biotechnology & Genome Portfolio ETF (PBE) Stock Price Today, Quote & News

Invesco Dynamic Biotechnology & Genome Portfolio ETF is neither suitable for income seeking investors, nor is suitable for long term investment. The fund claims to select Genomic revolution as its theme. However, it fails to focus only on such companies, and invests across the biotechnology sector. Genomic revolution has good growth prospects. But I dont think PBE will be able to capitalize on it for its lack of focus. Though the fund is well diversified within large, mid, and small cap biotechnology firms, the combination of stocks in its portfolio failed to generate returns. This portfolio will only generate return, only when the entire biotechnology sector will be on a boom. Another very important thing to note about PBE is, investors cant hedge their exposure by buying or selling call and put options. There is only one call option on September 16, 2022 available at a strike price of $65. In my opinion, there are much better biotechnology ETFs available in the market, such as FBT, and BIB.

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Cyberpunk 2077 Player Discovers One of the Games Most Brutal Deaths – HITC – Football, Gaming, Movies, TV, Music

Posted: at 7:53 pm

CD Projekt Reds deep dive into the futuristic world of the Night City has been filled with highs and lows since its release in November 2020. Due to a bumpy launch, Cyberpunk 2077 has since its fair share of glitches and crazy bugs that almost hammered the last nail in its coffin.

Thankfully, due to next-gen improvements implemented via its newest update, players are finding the title a lot better to get to grips with and in the process, some out of this world combat sequences to boot.

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In a new post on Reddit, a player has found one of Cyberpunks most brutal and savage deaths. The sneaky gamer slips around the back of one of the enemies, sword at the ready. Finding the perfect moment of impact that also so happens to be right beside a gas canister, they slice the foe through the body which also sets off an explosion.

Unfortunately for the enemy, the force blows off most of their limbs leaving them bodiless and gripping the sword in one final attempt for survival before falling to the floor in a lifeless heap.

In a world asruthless as Night City, you come to expect that boundaries are pushed to their limit which makes for some of the most disturbing moments, as seen in this brutal showdown.

Reddit user u/Hyd_xx who posted the video stated This new patch really changed up the gameplay a lot, they added perks that can reduce the explosion damage to yourself so you wont die instantly if youre next to one etc. But I love the new melee execution the most lol

If you dont own Cyberpunk 2077 for yourself and fancy giving it a try, a new trial version is available to download and play until 15th March 2022, which grants you access to Night City for five hours.

In other news, Pokemon Gen 9 Region: Fans bet on Iberian Peninsula map

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Cyberpunk 2077 Dev CDPR And Others Condemn Russias Invasion Of Ukraine – Kotaku

Posted: at 7:53 pm

Protestors from the Christian Ukrainian Community of Rome hold banners in support of Ukraine following Russias invasion.Photo: Alessandra Benedetti-Corbis (Getty Images)

Earlier this week Russian troops, acting on the orders of President Vladimir Putin, invaded Ukraine and launched 200 missiles, some of which reportedly hit residential areas near the capital city of Kyiv. At least 50,000 Ukrainian citizens have been displaced and are fleeing the country, according to CNN. While some game developers based in Ukraine responded promptly to this act of aggression, now an increasing number of studios outside the invaded nation, including Cyberpunk 2077 maker CD Projekt Red, are also speaking out in solidarity with the Ukrainian people and in condemnation of Russias actions.

Read More: Ukraine Game Developers Respond To Russian Invasion [Update]

11 Bit Studios, the Polish studio behind Frostpunk and the anti-war survival game This War of Mine, came out in vigorous opposition to the war, releasing a statement on Twitter brandishing the #FuckTheWar hashtag and reading, in part, Let this message resonate with everything you know about this war and how war kills people, devastates their lives and homes. The statement also declared that all profits earned from This War of Mine for the next seven days will be donated to the Ukrainian Red Cross to aid victims of the war.

This morning, Cyberpunk 2077 developer CD Projekt Red, also based in Poland which borders Ukraine to the west, announced on Twitter that it will be donating 1 million PLN (or Polish zloty), roughly $242,400 USD, to Polska Akcja Humanitarna, a Poland-based humanitarian group in support of Ukrainian victims.

The recent invasion on Ukraine, our friends and neighbours, left us shocked and outraged, CD Projekt Red said on Twitter. We cannot remain indifferent in the face of such injustice and we ask everybody to join in and help in any way you can. Together we can make a huge difference!

Crytivo, the California-based indie game publisher and developer behind the city-builder game The Universim, posted a statement on Twitter yesterday signed by CEO and founder Alex Koshelkov announcing that it will be donating all proceeds from February and March to the Ukrainian Red Cross. Koshelkov also said that Crytivo will be giving its Ukrainian employees paid leave until they can find a safe environment that will allow them to work again.

With the recent military development in Ukraine, I feel obliged to let our fans and others know that our company Crytivo is firmly anti-war as we stand with the people of Ukraine, Koshelkovs statement said. The last couple years have already been difficult for us all and I hope we can inspire others to lend a helping hand to our brothers and sisters in need.

State of Play Games, the Czech developers behind the BAFTA-award-winning puzzle game Lumino City, also issued a statement this morning saying it will be joining 11 Bit studios in solidarity with Ukraine by donating all proceeds from its games on the App Store, Google Play, and Steam to the Ukrainian Red Cross.

And Amanita Design, the Czech studio behind the psychedelic horror game Happy Game, announced on Twitter that itll be donating its earnings from Machinarium, CHUCHEL, and Creaks next week to Clovekvtisni, a nonprofit organization based in Prague that it said would use the money to aid the most vulnerable people in Ukraine affected by the ongoing Russian invasion. Amanita Design also thanked 11 Bit studios and State of Play Games in a following tweet for inspiring it to come out in solidarity with Ukraine.

Ukraine needs help right now, Amanita Design said in a statement. We condemn the Russian invasion of Ukraine. This horrible act of aggression has absolutely no place in any democratic society.

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Second Amendment to the United States Constitution – Wikipedia

Posted: at 7:52 pm

The Second Amendment (Amendment II) to the United States Constitution protects the right to keep and bear arms. It was ratified on December 15, 1791, along with nine other articles of the Bill of Rights.[1][2][3] In District of Columbia v. Heller (2008), the Supreme Court affirmed for the first time that the right belongs to individuals, for self-defense in the home,[4][5][6][7] while also including, as dicta, that the right is not unlimited and does not preclude the existence of certain long-standing prohibitions such as those forbidding "the possession of firearms by felons and the mentally ill" or restrictions on "the carrying of dangerous and unusual weapons".[8][9] In McDonald v. City of Chicago (2010) the Supreme Court ruled that state and local governments are limited to the same extent as the federal government from infringing upon this right.[10][11]

The Second Amendment was based partially on the right to keep and bear arms in English common law and was influenced by the English Bill of Rights of 1689. Sir William Blackstone described this right as an auxiliary right, supporting the natural rights of self-defense and resistance to oppression, and the civic duty to act in concert in defense of the state.[12] Any labels of rights as auxiliary must be viewed in the context of the inherent purpose of a Bill of Rights, which is to empower a group with the ability to achieve a mutually desired outcome, and not to necessarily enumerate or rank the importance of rights. While both James Monroe and John Adams supported the Constitution being ratified, its most influential framer was James Madison. In Federalist No. 46, Madison wrote how a federal army could be kept in check by state militias, "a standing army... would be opposed [by] a militia." He argued that state militias "would be able to repel the danger" of a federal army, "It may well be doubted, whether a militia thus circumstanced could ever be conquered by such a proportion of regular troops." He contrasted the federal government of the United States to the European kingdoms, which he described as "afraid to trust the people with arms", and assured that "the existence of subordinate governments... forms a barrier against the enterprises of ambition".[13][14]

By January 1788, Delaware, Pennsylvania, New Jersey, Georgia and Connecticut ratified the Constitution without insisting upon amendments. Several amendments were proposed, but were not adopted at the time the Constitution was ratified. For example, the Pennsylvania convention debated fifteen amendments, one of which concerned the right of the people to be armed, another with the militia. The Massachusetts convention also ratified the Constitution with an attached list of proposed amendments. In the end, the ratification convention was so evenly divided between those for and against the Constitution that the federalists agreed to the Bill of Rights to assure ratification. In United States v. Cruikshank (1876), the Supreme Court ruled that, "The right to bear arms is not granted by the Constitution; neither is it in any manner dependent upon that instrument for its existence. The Second Amendments [sic] means no more than that it shall not be infringed by Congress, and has no other effect than to restrict the powers of the National Government."[15] In United States v. Miller (1939), the Supreme Court ruled that the Second Amendment did not protect weapon types not having a "reasonable relationship to the preservation or efficiency of a well regulated militia".[16][17]

In the 21st century, the amendment has been subjected to renewed academic inquiry and judicial interest.[17] In District of Columbia v. Heller, the Supreme Court handed down a landmark decision that held the amendment protects an individual's right to keep a gun for self-defense.[18][19] This was the first time the Court had ruled that the Second Amendment guarantees an individual's right to own a gun.[20][21][19] In McDonald v. Chicago (2010), the Supreme Court clarified that the Due Process Clause of the Fourteenth Amendment incorporated the Second Amendment against state and local governments.[22] In Caetano v. Massachusetts (2016), the Supreme Court reiterated its earlier rulings that "the Second Amendment extends, prima facie, to all instruments that constitute bearable arms, even those that were not in existence at the time of the founding" and that its protection is not limited to "only those weapons useful in warfare". The debate between various organizations regarding gun control and gun rights continues.[23]

Contents

There are several versions of the text of the Second Amendment, each with capitalization or punctuation differences. Differences exist between the version passed by Congress and put on display and the versions ratified by the states.[24][25][26][27][28][29][30] These differences have been a focus of debate regarding the meaning of the amendment, particularly regarding the importance of what the courts have called the prefatory clause.[31][32]

The final, handwritten original of the Bill of Rights as passed by Congress, with the rest of the original prepared by scribe William Lambert, is preserved in the National Archives.[33] This is the version ratified by Delaware[34] and used by the Supreme Court in District of Columbia v. Heller:

A well regulated Militia, being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed.[35]

Some state-ratified versions omitted the first or final commas, such as Maryland's:[34][36][25]

A well regulated Militia being necessary to the security of a free State, the right of the people to keep and bear Arms, shall not be infringed.

The ratification acts from New York, Pennsylvania, Rhode Island, and South Carolina contained only one comma, but with differences in capitalization. Pennsylvania's act states:[37]

A well regulated Militia being necessary to the security of a free State, the right of the people to keep and bear Arms shall not be infringed.[38][39]

The ratification act from New Jersey has no commas:[34]

A well regulated Militia being necessary to the security of a free State the right of the people to keep and bear Arms shall not be infringed.

The right for Protestants to bear arms in English history is regarded in English common law as a subordinate auxiliary right of the primary rights to personal security, personal liberty, and private property. According to Sir William Blackstone, "The... last auxiliary right of the subject... is that of having arms for their defence, suitable to their condition and degree, and such as are allowed by law. Which is... declared by... statute, and is indeed a public allowance, under due restrictions, of the natural right of resistance and self-preservation, when the sanctions of society and laws are found insufficient to restrain the violence of oppression."[a]

The English Bill of Rights of 1689 emerged from a tempestuous period in English politics during which two issues were major sources of conflict: the authority of the King to govern without the consent of Parliament, and the role of Catholics in a country that was becoming ever more Protestant. Ultimately, the Catholic JamesII was overthrown in the Glorious Revolution, and his successors, the Protestants WilliamIII and MaryII, accepted the conditions that were codified in the Bill. One of the issues the Bill resolved was the authority of the King to disarm his subjects, after King Charles II and JamesII had disarmed many Protestants that were "suspected or knowne" of disliking the government,[40] and had argued with Parliament over his desire to maintain a standing (or permanent) army.[b] The bill states that it is acting to restore "ancient rights" trampled upon by JamesII, though some have argued that the English Bill of Rights created a new right to have arms, which developed out of a duty to have arms.[41] In District of Columbia v. Heller (2008), the Supreme Court did not accept this view, remarking that the English right at the time of the passing of the English Bill of Rights was "clearly an individual right, having nothing whatsoever to do with service in the militia" and that it was a right not to be disarmed by the Crown and was not the granting of a new right to have arms.[42]

The text of the English Bill of Rights of 1689 includes language protecting the right of Protestants against disarmament by the Crown, stating: "That the Subjects which are Protestants may have Arms for their Defence suitable to their Conditions and as allowed by Law."[43] It also contained text that aspired to bind future Parliaments, though under English constitutional law no Parliament can bind any later Parliament.[44]

The statement in the English Bill of Rights concerning the right to bear arms is often quoted only in the passage where it is written as above and not in its full context. In its full context it is clear that the bill was asserting the right of Protestant citizens not to be disarmed by the King without the consent of Parliament and was merely restoring rights to Protestants that the previous King briefly and unlawfully had removed. In its full context it reads:

Whereas the late King James the Second by the Assistance of diverse evil Councillors Judges and Ministers employed by him did endeavour to subvert and extirpate the Protestant Religion and the Laws and Liberties of this Kingdom (list of grievances including)... by causing several good Subjects being Protestants to be disarmed at the same time when Papists were both Armed and employed contrary to Law, (Recital regarding the change of monarch)... thereupon the said Lords Spiritual and Temporal and Commons pursuant to their respective Letters and Elections being now assembled in a full and free Representative of this Nation taking into their most serious Consideration the best means for attaining the Ends aforesaid Doe in the first place (as their Ancestors in like Case have usually done) for the Vindicating and Asserting their ancient Rights and Liberties, Declare (list of rights including)... That the Subjects which are Protestants may have Arms for their Defense suitable to their Conditions and as allowed by Law.[43]

The historical link between the English Bill of Rights and the Second Amendment, which both codify an existing right and do not create a new one, has been acknowledged by the U.S. Supreme Court.[c][d]

The English Bill of Rights includes the proviso that arms must be as "allowed by law". This has been the case before and after the passage of the Bill. While it did not override earlier restrictions on the ownership of guns for hunting, it is subject to the parliamentary right to implicitly or explicitly repeal earlier enactments.[45]

There is some difference of opinion as to how revolutionary the events of 168889 actually were, and several commentators make the point that the provisions of the English Bill of Rights did not represent new laws, but rather stated existing rights. Mark Thompson wrote that, apart from determining the succession, the English Bill of Rights did "little more than set forth certain points of existing laws and simply secured to Englishmen the rights of which they were already posessed [sic]."[46] Before and after the English Bill of Rights, the government could always disarm any individual or class of individuals it considered dangerous to the peace of the realm.[47] In 1765, William Blackstone wrote the Commentaries on the Laws of England describing the right to have arms in England during the 18th century as a subordinate auxiliary right of the subject that was "also declared" in the English Bill of Rights.[48][49]

The fifth and last auxiliary right of the subject, that I shall at present mention, is that of having arms for their defence, suitable to their condition and degree, and such as are allowed by law. Which is also declared by the same statute 1 W. & M. st.2. c.2. and is indeed a public allowance, under due restrictions, of the natural right of resistance and self-preservation, when the sanctions of society and laws are found insufficient to restrain the violence of oppression.[50]

Although there is little doubt that the writers of the Second Amendment were heavily influenced by the English Bill of Rights, it is a matter of interpretation as to whether they were intent on preserving the power to regulate arms to the states over the federal government (as the English Parliament had reserved for itself against the monarch) or whether it was intent on creating a new right akin to the right of others written into the Constitution (as the Supreme Court decided in Heller). Some in the United States have preferred the "rights" argument arguing that the English Bill of Rights had granted a right. The need to have arms for self-defence was not really in question. Peoples all around the world since time immemorial had armed themselves for the protection of themselves and others, and as organized nations began to appear these arrangements had been extended to the protection of the state.[51] Without a regular army and police force, it had been the duty of certain men to keep watch and ward at night and to confront and capture suspicious persons. Every subject had an obligation to protect the king's peace and assist in the suppression of riots.[52]

Settlers in Colonial America viewed the right to arms and/or the right to bear arms and/or state militias as important for one or more of these purposes (in no particular order):[e][f][54][55][56][57][58][59]

Which of these considerations were thought of as most important and ultimately found expression in the Second Amendment is disputed. Some of these purposes were explicitly mentioned in early state constitutions; for example, the Pennsylvania Constitution of 1776 asserted that, "the people have a right to bear arms for the defence of themselves and the state."[66]

During the 1760s pre-revolutionary period, the established colonial militia was composed of colonists, including many who were loyal to British rule. As defiance and opposition to British rule developed, a distrust of these Loyalists in the militia became widespread among the colonists known as Patriots, who favored independence from British rule. As a result, some Patriots created their own militias that excluded the Loyalists and then sought to stock independent armories for their militias. In response to this arms build-up, the British parliament established an embargo of firearms, parts and ammunition against the American colonies.[67] King George III also began disarming individuals who were in the most rebellious areas in the 1760s and 1770s.[68]

British and Loyalist efforts to disarm the colonial Patriot militia armories in the early phases of the American Revolution resulted in the Patriot colonists protesting by citing the Declaration of Rights, Blackstone's summary of the Declaration of Rights, their own militia laws and common law rights to self-defense.[69] While British policy in the early phases of the Revolution clearly aimed to prevent coordinated action by the Patriot militia, some have argued that there is no evidence that the British sought to restrict the traditional common law right of self-defense.[69] Patrick J. Charles disputes these claims citing similar disarming by the patriots and challenging those scholars' interpretation of Blackstone.[70]

The right of the colonists to arms and rebellion against oppression was asserted, for example, in a pre-revolutionary newspaper editorial in 1769 objecting to the Crown suppression of colonial opposition to the Townshend Acts:

Instances of the licentious and outrageous behavior of the military conservators of the peace still multiply upon us, some of which are of such nature, and have been carried to such lengths, as must serve fully to evince that a late vote of this town, calling upon its inhabitants to provide themselves with arms for their defense, was a measure as prudent as it was legal: such violences are always to be apprehended from military troops, when quartered in the body of a populous city; but more especially so, when they are led to believe that they are become necessary to awe a spirit of rebellion, injuriously said to be existing therein. It is a natural right which the people have reserved to themselves, confirmed by the Bill of Rights, to keep arms for their own defence; and as Mr. Blackstone observes, it is to be made use of when the sanctions of society and law are found insufficient to restrain the violence of oppression.[69][71]

The armed forces that won the American Revolution consisted of the standing Continental Army created by the Continental Congress, together with regular French army and naval forces and various state and regional militia units. In opposition, the British forces consisted of a mixture of the standing British Army, Loyalist militia and Hessian mercenaries. Following the Revolution, the United States was governed by the Articles of Confederation. Federalists argued that this government had an unworkable division of power between Congress and the states, which caused military weakness, as the standing army was reduced to as few as 80 men.[72] They considered it to be bad that there was no effective federal military crackdown on an armed tax rebellion in western Massachusetts known as Shays' Rebellion.[73] Anti-federalists, on the other hand, took the side of limited government and sympathized with the rebels, many of whom were former Revolutionary War soldiers. Subsequently, the Constitutional Convention proposed in 1787 to grant Congress exclusive power to raise and support a standing army and navy of unlimited size.[74][75] Anti-federalists objected to the shift of power from the states to the federal government, but as adoption of the Constitution became more and more likely, they shifted their strategy to establishing a bill of rights that would put some limits on federal power.[76]

Modern scholars Thomas B. McAffee and Michael J. Quinlan have stated that James Madison "did not invent the right to keep and bear arms when he drafted the Second Amendment; the right was pre-existing at both common law and in the early state constitutions."[77] In contrast, historian Jack Rakove suggests that Madison's intention in framing the Second Amendment was to provide assurances to moderate Anti-Federalists that the militias would not be disarmed.[78]

One aspect of the gun control debate is the conflict between gun control laws and the right to rebel against unjust governments. Blackstone in his Commentaries alluded to this right to rebel as the natural right of resistance and self preservation, to be used only as a last resort, exercisable when "the sanctions of society and laws are found insufficient to restrain the violence of oppression".[79] Some believe that the framers of the Bill of Rights sought to balance not just political power, but also military power, between the people, the states and the nation,[80] as Alexander Hamilton explained in his Concerning the Militia essay published in 1788:

...it will be possible to have an excellent body of well-trained militia, ready to take the field whenever the defence of the State shall require it. This will not only lessen the call for military establishments, but if circumstances should at any time oblige the Government to form an army of any magnitude, that army can never be formidable to the liberties of the People, while there is a large body of citizens, little, if at all, inferior to them in discipline and the use of arms, who stand ready to defend their own rights, and those of their fellow-citizens. This appears to me the only substitute that can be devised for a standing army, and the best possible security against it, if it should exist.[80][81]

Some scholars have said that it is wrong to read a right of armed insurrection into the Second Amendment because clearly the founding fathers sought to place trust in the power of the ordered liberty of democratic government versus the anarchy of insurrectionists.[82][83] Other writers, such as Glenn Reynolds, contend that the framers did believe in an individual right to armed insurrection. They cite examples, such as the Declaration of Independence (describing in 1776 "the Right of the People to... institute new Government") and the Constitution of New Hampshire (stating in 1784 that "nonresistance against arbitrary power, and oppression, is absurd, slavish, and destructive of the good and happiness of mankind").[84]

There was an ongoing debate beginning in 1789 about "the people" fighting governmental tyranny (as described by Anti-Federalists); or the risk of mob rule of "the people" (as described by the Federalists) related to the increasingly violent French Revolution.[85] A widespread fear, during the debates on ratifying the Constitution, was the possibility of a military takeover of the states by the federal government, which could happen if the Congress passed laws prohibiting states from arming citizens,[g] or prohibiting citizens from arming themselves.[69] Though it has been argued that the states lost the power to arm their citizens when the power to arm the militia was transferred from the states to the federal government by ArticleI, Section8 of the Constitution, the individual right to arm was retained and strengthened by the Militia Acts of 1792 and the similar act of 1795.[86][87]

Note: On May 10, 1776, Congress passed a resolution recommending that any colony with a government that was not inclined toward independence should form one that was.[88]

Virginia's Constitution lists the reasons for dissolving its ties with the King in the formation of its own independent state government. Including the following:

* These same reasons would later be outlined within the Declaration of Independence.

A Declaration of Rights. Section 13. That a well-regulated militia, composed of the body of the people, trained to arms, is the proper, natural, and safe defence of a free State; that standing armies, in time of peace, should be avoided, as dangerous to liberty; and that in all cases the military should be under strict subordination to, and governed by, the civil power.[89]

Article 13. That the people have a right to bear arms for the defence of themselves and the state; and as standing armies in the time of peace are dangerous to liberty, they ought not to be kept up; And that the military should be kept under strict subordination to, and governed by, the civil power.[90]

This is the first instance in relationship to U.S. Constitutional Law of the phrase "right to bear arms".

Article 43. The inhabitants of this state shall have the liberty to fowl and hunt in seasonable times on the lands they hold, and on all other lands therein not inclosed;[91]

It is relevant that Pennsylvania was a Quaker Colony traditionally opposed to bearing arms. "In settling Pennsylvania, William Penn had a great experiment in view, a 'holy experiment', as he term[ed] it. This was no less than to test, on a scale of considerable magnitude, the practicability of founding and governing a State on the sure principles of the Christian religion; where the executive should be sustained without arms; where justice should be administered without oaths; and where real religion might flourish without the incubus of a hierarchical system."[92] The Non-Quaker residents, many from the Western Counties, complained often and loudly of being denied the right to a common defense. By the time of the American Revolution, through what could be described as a revolution within a revolution, the pro-militia factions had gained ascendancy in the state's government. And by a manipulation through the use of oaths, disqualifying Quaker members, they made up a vast majority of the convention forming the new state constitution; it was only natural that they would assert their efforts to form a compulsory State Militia in the context of a "right" to defend themselves and the state.[93]

Articles XXV-XXVII. 25. That a well-regulated militia is the proper and natural defence of a free government. 26. That standing armies are dangerous to liberty, and ought not to be raised or kept up, without consent of the Legislature. 27. That in all cases, and at all times, the military ought to be under strict subordination to and control of the civil power.[94]

A Declaration of Rights. Article XVII. That the people have a right to bear arms, for the defence of the State; and, as standing armies, in time of peace, are dangerous to liberty, they ought not to be kept up; and that the military should be kept under strict subordination to, and governed by, the civil power.[95]

Article XL. And whereas it is of the utmost importance to the safety of every State that it should always be in a condition of defence; and it is the duty of every man who enjoys the protection of society to be prepared and willing to defend it; this convention therefore, in the name and by the authority of the good people of this State, doth ordain, determine, and declare that the militia of this State, at all times hereafter, as well in peace as in war, shall be armed and disciplined, and in readiness for service. That all such of the inhabitants of this State being of the people called Quakers as, from scruples of conscience, may be averse to the bearing of arms, be therefrom excused by the legislature; and do pay to the State such sums of money, in lieu of their personal service, as the same; may, in the judgment of the legislature, be worth. And that a proper magazine of warlike stores, proportionate to the number of inhabitants, be, forever hereafter, at the expense of this State, and by acts of the legislature, established, maintained, and continued in every county in this State.[96]

Chapter 1. Section XVIII. That the people have a right to bear arms for the defence of the themselves and the State; and as standing armies, in the time of peace, are dangerous to liberty, they ought not to be kept up; and that the military should be kept under strict subordination to, and governed by, the civil power.[97]

A Declaration of Rights. Chapter 1. Article XVII. The people have a right to keep and to bear arms for the common defence. And as, in time of peace, armies are dangerous to liberty, they ought not to be maintained without the consent of the legislature; and the military power shall always be held in an exact subordination to the civil authority and be governed by it.[98]

In March 1785, delegates from Virginia and Maryland assembled at the Mount Vernon Conference to fashion a remedy to the inefficiencies of the Articles of Confederation. The following year, at a meeting in Annapolis, Maryland, 12 delegates from five states (New Jersey, New York, Pennsylvania, Delaware, and Virginia) met and drew up a list of problems with the current government model. At its conclusion, the delegates scheduled a follow-up meeting in Philadelphia, Pennsylvania for May 1787 to present solutions to these problems, such as the absence of:[102][103]

It quickly became apparent that the solution to all three of these problems required shifting control of the states' militias to the federal Congress and giving it the power to raise a standing army.[104] Article 1, Section 8 of the Constitution codified these changes by allowing the Congress to provide for the common defense and general welfare of the United States by doing the following:[105]

Some representatives mistrusted proposals to enlarge federal powers, because they were concerned about the inherent risks of centralizing power. Federalists, including James Madison, initially argued that a bill of rights was unnecessary, sufficiently confident that the federal government could never raise a standing army powerful enough to overcome a militia.[106] Federalist Noah Webster argued that an armed populace would have no trouble resisting the potential threat to liberty of a standing army.[107][108] Anti-federalists, on the other hand, advocated amending the Constitution with clearly defined and enumerated rights providing more explicit constraints on the new government. Many Anti-federalists feared the new federal government would choose to disarm state militias. Federalists countered that in listing only certain rights, unlisted rights might lose protection. The Federalists realized there was insufficient support to ratify the Constitution without a bill of rights and so they promised to support amending the Constitution to add a bill of rights following the Constitution's adoption. This compromise persuaded enough Anti-federalists to vote for the Constitution, allowing for ratification.[109] The Constitution was declared ratified on June21, 1788, when nine of the original thirteen states had ratified it. The remaining four states later followed suit, although the last two states, North Carolina and Rhode Island, ratified only after Congress had passed the Bill of Rights and sent it to the states for ratification.[110] James Madison drafted what ultimately became the Bill of Rights, which was proposed by the first Congress on June8, 1789, and was adopted on December15, 1791.

The debate surrounding the Constitution's ratification is of practical importance, particularly to adherents of originalist and strict constructionist legal theories. In the context of such legal theories and elsewhere, it is important to understand the language of the Constitution in terms of what that language meant to the people who wrote and ratified the Constitution.[111]

Robert Whitehill, a delegate from Pennsylvania, sought to clarify the draft Constitution with a bill of rights explicitly granting individuals the right to hunt on their own land in season,[112] though Whitehill's language was never debated.[113]

There was substantial opposition to the new Constitution because it moved the power to arm the state militias from the states to the federal government. This created a fear that the federal government, by neglecting the upkeep of the militia, could have overwhelming military force at its disposal through its power to maintain a standing army and navy, leading to a confrontation with the states, encroaching on the states' reserved powers and even engaging in a military takeover. Article VI of the Articles of Confederation states:

No vessel of war shall be kept up in time of peace by any State, except such number only, as shall be deemed necessary by the united States in congress assembled, for the defense of such State, or its trade; nor shall any body of forces be kept up by any State in time of peace, except such number only, as in the judgement of the united States, in congress assembled, shall be deemed requisite to garrison the forts necessary for the defense of such State; but every State shall always keep up a well-regulated and disciplined militia, sufficiently armed and accoutered, and shall provide and constantly have ready for use, in public stores, a due number of field pieces and tents, and a proper quantity of arms, ammunition and camp equipage.[114][115]

In contrast, Article I, Section 8, Clause 16 of the U.S. Constitution states:

To provide for organizing, arming, and disciplining, the Militia, and for governing such Part of them as may be employed in the Service of the United States, reserving to the States respectively, the Appointment of the Officers, and the Authority of training the Militia according to the discipline prescribed by Congress.[116]

A foundation of American political thought during the Revolutionary period was concerned about political corruption and governmental tyranny. Even the federalists, fending off their opponents who accused them of creating an oppressive regime, were careful to acknowledge the risks of tyranny. Against that backdrop, the framers saw the personal right to bear arms as a potential check against tyranny. Theodore Sedgwick of Massachusetts expressed this sentiment by declaring that it is "a chimerical idea to suppose that a country like this could ever be enslaved... Is it possible... that an army could be raised for the purpose of enslaving themselves or their brethren? Or, if raised whether they could subdue a nation of freemen, who know how to prize liberty and who have arms in their hands?"[117] Noah Webster similarly argued:

Before a standing army can rule the people must be disarmed; as they are in almost every kingdom in Europe. The supreme power in America cannot enforce unjust laws by the sword; because the whole body of the people are armed, and constitute a force superior to any band of regular troops that can be, on any pretence, raised in the United States.[13][118]

George Mason also argued the importance of the militia and right to bear arms by reminding his compatriots of the British government's efforts "to disarm the people; that it was the best and most effectual way to enslave them... by totally disusing and neglecting the militia." He also clarified that under prevailing practice the militia included all people, rich and poor. "Who are the militia? They consist now of the whole people, except a few public officers." Because all were members of the militia, all enjoyed the right to individually bear arms to serve therein.[13][119]

Writing after the ratification of the Constitution, but before the election of the first Congress, James Monroe included "the right to keep and bear arms" in a list of basic "human rights", which he proposed to be added to the Constitution.[120]

Patrick Henry argued in the Virginia ratification convention on June 5, 1788, for the dual rights to arms and resistance to oppression:

Guard with jealous attention the public liberty. Suspect everyone who approaches that jewel. Unfortunately, nothing will preserve it but downright force. Whenever you give up that force, you are inevitably ruined.[121]

In the slave states, the militia was available for military operations, but its biggest function was to police the slaves.[122][123] According to Dr Carl T. Bogus, Professor of Law of the Roger Williams University Law School in Rhode Island,[122] the Second Amendment was written to assure the Southern states that Congress would not undermine the slave system by using its newly acquired constitutional authority over the militia to disarm the state militia and thereby destroy the South's principal instrument of slave control.[124]In his close analysis of James Madison's writings, Bogus describes the South's obsession with militias during the ratification process:[124]

The militia remained the principal means of protecting the social order and preserving white control over an enormous black population. Anything that might weaken this system presented the gravest of threats.

This preoccupation is clearly expressed in 1788[124] by the slaveholder Patrick Henry:

If the country be invaded, a state may go to war, but cannot suppress insurrections [under this new Constitution]. If there should happen an insurrection of slaves, the country cannot be said to be invaded. They cannot, therefore, suppress it without the interposition of Congress ... Congress, and Congress only [under this new Constitution; addition not mentioned in source], can call forth the militia.[122]

Therefore, Bogus argues, in a compromise with the slave states, and to reassure Patrick Henry, George Mason and other slaveholders that they would be able to keep their slave control militias independent of the federal government, James Madison (also slave owner) redrafted the Second Amendment into its current form "for the specific purpose of assuring the Southern states, and particularly his constituents in Virginia, that the federal government would not undermine their security against slave insurrection by disarming the militia."[124]

Legal historian Paul Finkelman argues that this scenario is implausible.[65] Henry and Mason were political enemies of Madison's, and neither man was in Congress at the time Madison drafted Bill of Rights; moreover, Patrick Henry argued against the ratification of both the Constitution and the Second Amendment, and it was Henry's opposition that led Patrick's home state of Virginia to be the last to ratify.[65]

Most Southern white men betweenthe ages of 18 and 45 were required to serve on "slave patrols" which were organized groups of white men who enforced discipline upon enslaved blacks.[125] Bogus writes with respect to Georgia laws passed in 1755 and 1757 in this context: "The Georgia statutes required patrols, under the direction of commissioned militia officers, to examine every plantation each month and authorized them to search 'all Negro Houses for offensive Weapons and Ammunition' and to apprehend and give twenty lashes to any slave found outside plantation grounds."[126][127][unreliable source]

Finkelman recognises that James Madison "drafted an amendment to protect the right of the states to maintain their militias," but insists that "The amendment had nothing to do with state police powers, which were the basis of slave patrols."[65]

According to Pennsylvania attorney Anthony Picadio, the Southern slave states would never have ratified the Second Amendment if it had been understood as creating an individual right to own firearms because of their fear of arming free blacks, hence the emphasis on the phrase "well regulated Militia", introducing the Second Amendment.

Firstly, slave owners feared that enslaved blacks might be emancipated through military service. A few years earlier, there had been a precedent when Lord Dunmore offered freedom to slaves who escaped and joined his forces with "Liberty to Slaves" stitched onto their jacket pocket flaps. Freed slaves also served in General Washington's army.

Secondly, they also greatly feared "a ruinous slave rebellion in which their families would be slaughtered and their property destroyed." When Virginia ratified the Bill of Rights on December 15, 1791, the Haitian Revolution, a successful slave rebellion, was under way. The right to bear arms was therefore deliberately tied to membership in a militia by the slaveholder and chief drafter of the Amendment, James Madison, because only whites could join militias in the South.[128]

In 1776, Thomas Jefferson had submitted a draft constitution for Virginia that said "no freeman shall ever be debarred the use of arms within his own lands or tenements". According to Picadio, this version was rejected because "it would have given to free blacks the constitutional right to have firearms".[129]

James Madison's initial proposal for a bill of rights was brought to the floor of the House of Representatives on June 8, 1789, during the first session of Congress. The initial proposed passage relating to arms was:

The right of the people to keep and bear arms shall not be infringed; a well armed and well regulated militia being the best security of a free country: but no person religiously scrupulous of bearing arms shall be compelled to render military service in person.[130]

On July 21, Madison again raised the issue of his bill and proposed that a select committee be created to report on it. The House voted in favor of Madison's motion,[131] and the Bill of Rights entered committee for review. The committee returned to the House a reworded version of the Second Amendment on July 28.[132] On August 17, that version was read into the Journal:

A well regulated militia, composed of the body of the people, being the best security of a free State, the right of the people to keep and bear arms shall not be infringed; but no person religiously scrupulous shall be compelled to bear arms.[133]

In late August 1789, the House debated and modified the Second Amendment. These debates revolved primarily around the risk of "mal-administration of the government" using the "religiously scrupulous" clause to destroy the militia as British forces had attempted to destroy the Patriot militia at the commencement of the American Revolution. These concerns were addressed by modifying the final clause, and on August 24, the House sent the following version to the Senate:

A well regulated militia, composed of the body of the people, being the best security of a free state, the right of the people to keep and bear arms shall not be infringed; but no one religiously scrupulous of bearing arms shall be compelled to render military service in person.

The next day, August 25, the Senate received the amendment from the House and entered it into the Senate Journal. However, the Senate scribe added a comma before "shall not be infringed" and changed the semicolon separating that phrase from the religious exemption portion to a comma:

A well regulated militia, composed of the body of the people, being the best security of a free state, the right of the people to keep and bear arms, shall not be infringed, but no one religiously scrupulous of bearing arms shall be compelled to render military service in person.[134]

By this time, the proposed right to keep and bear arms was in a separate amendment, instead of being in a single amendment together with other proposed rights such as the due process right. As a representative explained, this change allowed each amendment to "be passed upon distinctly by the States".[135] On September 4, the Senate voted to change the language of the Second Amendment by removing the definition of militia, and striking the conscientious objector clause:

A well regulated militia, being the best security of a free state, the right of the people to keep and bear arms, shall not be infringed.[136]

The Senate returned to this amendment for a final time on September 9. A proposal to insert the words "for the common defence" next to the words "bear arms" was defeated. A motion passed to replace the words "the best", and insert in lieu thereof "necessary to the" .[137] The Senate then slightly modified the language to read as the fourth article and voted to return the Bill of Rights to the House. The final version by the Senate was amended to read as:

A well regulated militia being necessary to the security of a free state, the right of the people to keep and bear arms, shall not be infringed.

The House voted on September 21, 1789, to accept the changes made by the Senate.

The enrolled original Joint Resolution passed by Congress on September 25, 1789, on permanent display in the Rotunda, reads as:

A well regulated militia, being necessary to the security of a free State, the right of the People to keep and bear arms, shall not be infringed.[138]

On December 15, 1791, the Bill of Rights (the first ten amendments to the Constitution) was adopted, having been ratified by three-fourths of the states, having been ratified as a group by all the fourteen states then in existence except Connecticut, Massachusetts, and Georgia which added ratifications in 1939.[139]

During the first two decades following the ratification of the Second Amendment, public opposition to standing armies, among Anti-Federalists and Federalists alike, persisted and manifested itself locally as a general reluctance to create a professional armed police force, instead relying on county sheriffs, constables and night watchmen to enforce local ordinances.[67] Though sometimes compensated, often these positions were unpaid held as a matter of civic duty. In these early decades, law enforcement officers were rarely armed with firearms, using billy clubs as their sole defensive weapons.[67] In serious emergencies, a posse comitatus, militia company, or group of vigilantes assumed law enforcement duties; these individuals were more likely than the local sheriff to be armed with firearms.[67]

On May 8, 1792, Congress passed "[a]n act more effectually to provide for the National Defence, by establishing an Uniform Militia throughout the United States" requiring:

[E]ach and every free able-bodied white male citizen of the respective States, resident therein, who is or shall be of age of eighteen years, and under the age of forty-five years (except as is herein after excepted) shall severally and respectively be enrolled in the militia... [and] every citizen so enrolled and notified, shall, within six months thereafter, provide himself with a good musket or firelock, a sufficient bayonet and belt, two spare flints, and a knapsack, a pouch with a box therein to contain not less than twenty-four cartridges, suited to the bore of his musket or firelock, each cartridge to contain a proper quantity of powder and ball: or with a good rifle, knapsack, shot-pouch and powder-horn, twenty balls suited to the bore of his rifle, and a quarter of a pound of powder; and shall appear, so armed, accoutred and provided, when called out to exercise, or into service, except, that when called out on company days to exercise only, he may appear without a knapsack.[140]

The act also gave specific instructions to domestic weapon manufacturers "that from and after five years from the passing of this act, muskets for arming the militia as herein required, shall be of bores sufficient for balls of the eighteenth part of a pound."[140] In practice, private acquisition and maintenance of rifles and muskets meeting specifications and readily available for militia duty proved problematic; estimates of compliance ranged from 10 to 65percent.[141] Compliance with the enrollment provisions was also poor. In addition to the exemptions granted by the law for custom-house officers and their clerks, post-officers and stage drivers employed in the care and conveyance of U.S. mail, ferrymen, export inspectors, pilots, merchant mariners and those deployed at sea in active service; state legislatures granted numerous exemptions under Section2 of the Act, including exemptions for: clergy, conscientious objectors, teachers, students, and jurors. Though a number of able-bodied white men remained available for service, many simply did not show up for militia duty. Penalties for failure to appear were enforced sporadically and selectively.[142] None is mentioned in the legislation.[140]

The first test of the militia system occurred in July 1794, when a group of disaffected Pennsylvania farmers rebelled against federal tax collectors whom they viewed as illegitimate tools of tyrannical power.[143] Attempts by the four adjoining states to raise a militia for nationalization to suppress the insurrection proved inadequate. When officials resorted to drafting men, they faced bitter resistance. Forthcoming soldiers consisted primarily of draftees or paid substitutes as well as poor enlistees lured by enlistment bonuses. The officers, however, were of a higher quality, responding out of a sense of civic duty and patriotism, and generally critical of the rank and file.[67] Most of the 13,000 soldiers lacked the required weaponry; the war department provided nearly two-thirds of them with guns.[67] In October, President George Washington and General Harry Lee marched on the 7,000rebels who conceded without fighting. The episode provoked criticism of the citizen militia and inspired calls for a universal militia. Secretary of War Henry Knox and Vice President John Adams had lobbied Congress to establish federal armories to stock imported weapons and encourage domestic production.[67] Congress did subsequently pass "[a]n act for the erecting and repairing of Arsenals and Magazines" on April 2, 1794, two months prior to the insurrection.[144] Nevertheless, the militia continued to deteriorate and twenty years later, the militia's poor condition contributed to several losses in the War of 1812, including the sacking of Washington, D.C., and the burning of the White House in 1814.[142]

In the 20th century, Congress passed the Militia Act of 1903. The act defined the militia as every able-bodied male aged 18 to 44 who was a citizen or intended to become one. The militia was then divided by the act into the United States National Guard and the unorganized Reserve Militia.[145][146]

Federal law continues to define the militia as all able-bodied males aged 17 to 44, who are citizens or intend to become one, and female citizens who are members of the National Guard. The militia is divided into the organized militia, which consists of the National Guard and Naval Militia, and the unorganized militia.[147]

In May of 1788, Richard Henry Lee wrote in Additional Letters From The Federal Farmer #169 or Letter XVIII regarding the definition of a "militia":

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Second Amendment to the United States Constitution - Wikipedia

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10 Truths About The Basis of Our Second Amendment Freedom That, Too Often, Are Not Being Taught | An Official Journal Of The NRA – America’s 1st…

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Ronald Reagan once warned that freedom is never more than one generation away from extinction. Because we cannot pass it on to our children in the bloodstream, he said, we must hand it to them with the well-thought lessons of how they can fight for it, protect it [and] defend it, so that they, too, can pass it on to the next generation.

Tragically, our workone of us as a law professor and one a constitutional lawyerhas shown us that the values of a free societythe rule of law, self-determination, tolerance and accountability, to name a feware in some disrepair.

Several influential forces, including many educators and members of the media, have taught recent generations that freedom is not always worth defending; instead, they maintain that even our right to self-preservation, via our Second Amendment rights, is just another antiquated value to be sacrificed for notions of security, equity and statism.

Thus, it is more important than ever to ensure that the young people in our lives are taught the fundamentals of American freedom. To that end, here are 10 lessons that all Americans should know about their rights.

1. We all have natural rights, which are granted by our Creator, not our government.Everyone is born with natural rights, which are inherent in all of us simply because we are human. These universal and immutable rights include life, liberty, free speech, freedom of conscience, the right to self-defense and the right to property, among others. Everyone is endowed with natural rights regardless of race, religion, class or other category. As George Mason put it: All men are born equally free and independent, and have certain inherent natural rights, of which they cannot by any compact deprive or divest their posterity.

2. Our government exists to protect our natural rights.The Declaration of Independence famously declares that all men are created equal and are endowed by their Creator with certain unalienable Rights, such as Life, Liberty and the pursuit of Happiness. It is to secure these rights, that Governments are instituted among Men, deriving their just powers from the consent of the governed. So, our government exists to protect our rights, and must protect everyones rights equally. Moreover, far from a government that grants rights to the people it governs, it is the American people, through the consent of the governed, that grants the government its powers. And not any powersonly just powers. Such powers do not include the authority to infringe on natural rights, even if a majority of the people consent. That is clear because the whole purpose of government is to secure these rights.

3. The U.S. Bill of Rights codified preexisting rights.The Second Amendment codified a right that already existedthe Second Amendments text does not create a right, but instead declares that the preexisting natural right shall not be infringed. Thus, as the U.S. Supreme Court has recognized, this is not a right granted by the Constitution. Neither is it in any manner dependent upon that instrument for its existence. Consequently, repealing the Second Amendment would accomplish little under the original understanding of the American system of government. That said, there is no doubt that the goal of the anti-rights movement is to disregard the original understanding of rights in America, repeal the Second Amendment and eliminate gun ownership; as a result, despite the preexisting nature of the right, we can never relent in our fierce defense of it. The same applies to the rest of the U.S. Bill of Rights, including parts that are less important to us individually.

4. The Constitution is an anti-majoritarian document.The purpose of a constitution is to restrain government from imposing a tyranny of the majority, which, according to philosopher John Stuart Mill in his famous work, On Liberty, operat[es] through the acts of the public authorities.

Legislatures are particularly susceptible to majoritarian pressures because they are elected and responsible for making (rather than enforcing) laws. In James Madisons words from Federalist No. 10, the Constitution ensures that government cannot serve the superior force of an interested and overbearing majority at the expense of the rights of the minority. Whether the right protected is equal protection, unpopular speech or the right to keep and bear arms, as the U.S. Supreme Court said in District of Columbia v. Heller (2008), the enshrinement of constitutional rights necessarily takes certain policy choices off the table.

5. No onejudges or otherwiseshould rank rights.Rights are valuable for their own sake. Ranking them is necessarily a majoritarian act because it requires making a policy choice about whether one right is more valuable than another. Whenever rights are chosen for special (or especially bad) treatment by the legislative, judicial or executive branch, the result will be that disfavored groupsthose wishing to exercise disfavored rightswill be on the losing end of any government-decreed rights hierarchy.

6. If the Constitution doesnt mean what it was meant to say, it doesnt mean anything.If judges have license to enforce their (or what they perceive to be societys) norms when interpreting the U.S. Constitution, it can no longer serve as an effective constraint on government or the majority.

Take the 1934 case of Home Building & Loan Association v. Blaisdell, in which the plaintiff challenged a Minnesota law creating a moratorium on mortgage foreclosures. Plaintiff brought its claim under the Contracts Clause of the U.S. Constitution, which declares that No State shall ... pass any ... Law impairing the Obligation of Contracts. The U.S. Supreme Court acknowledged that evidence presented in the case showed that it was this type of debtor-relief legislation that the Contracts Clause intended to prohibit. Nevertheless, it upheld the law, declaring: It is no answer to say ... that what the provision of the Constitution meant to the vision of [the Founding] it must mean to the vision of our time. In other words, the Court said that the Contracts Clause did not today prohibit the very government action that it was intended to prohibit when it was enacted. It is difficult to see how the Clause could mean anything under such a reading.

7. For more liberty and better representation, most decisions should be made at the state and local levels.The American system of government is designed to ensure that the decisions impacting your life are made as locally as possible. Thomas Jefferson argued that generalising & concentrating all cares and powers into one body ... has destroyed liberty and the rights of man in every government which has ever existed under the sun. Thus, Jefferson explained, the way to have good and safe government, is not to trust it all to one [central government]; but to divide it among the many. [I]t is by dividing and subdividing these republics from the great National one down thro all its subordinations, until it ends in the administration of every mans farm and affairs by himself ... that all will be done for the best.

The more centralized government power becomes, the less representative it can be of a diverse people. This is harmful to individual liberty and unity among the states. According to Jeffersons vision of the Constitution, our General Government may be reduced to a very simple organization, and a very inexpensive one; a few plain duties to be performed by a few servants.

In Federalist No. 45, Madison explained how this principle applies to the Constitutions balance between state and federal power. While the powers delegated by the proposed constitution to the federal government, are few and defined, those that remain in the state government, are numerous and indefinite. While federal powers will be exercised principally on external objects, [such] as war, peace, negotiation, and foreign commerce, the powers reserved to the several states will extend to all the objects, which, in the ordinary course of affairs, concern the lives, liberties, and properties of the people; and the internal order, improvement, and prosperity of the state. Therefore, [t]he operations of the federal government will be most extensive and important in the times of war and danger; those of the state governments in times of peace and security.

The federal government has grown far beyond what the Founders envisioned. Its operations are extensive during times of peace and security, and they affect countless aspects of our daily lives. The larger the federal government becomes, the less liberty each American has, because the governments powerits ability to restrict or require certain behaviorsnecessarily comes at the expense of individual choice.

8. We have equal rights, which is not, and should not be, a guarantee of equal results.A central purpose of our government is to ensure equal treatment under law, regardless of occupation, gender, race or religion. This does not, however, translate to equal results. Individuals have different skills, motivations, goals and values. They will inevitably reach different outcomes in a free society, even when they receive equal treatment. Thus, Alexander Hamilton explained that inequality would exist as long as liberty existed, and that it would unavoidably result from that very liberty itself. It is governments role to protect individuals rights so that they may pursue happiness; it is not governments job to guarantee success in achieving it.

9. The Constitution is a tyranny-control document.The United States government was not established by a conquering army, dictator or emperor for the purpose of retaining authority over the people it rules. George Washington led America in defeating a tyrant, andto much of the worlds surprisehe sent his army home and resigned his military commission when the War for American Independence ended. He did not want to be president, though some people were actually willing to make him king. But what of future governments?

Americas Founders, being students of history, were acutely aware of the long history of governments turned despotic, as well as the ability of power to corrupt. They therefore built a constitution that made it more difficult for the government to turn on its people. Structural limits on government, like separation of powers among the branches of government and the division of power between federal and state governments, ensure that it is difficult for power to coalesce in one place. Individual rightslike the right to speak freely in criticizing the government, the right to bear arms, the right to a jury trial and prohibitions against bills of attainder (which prevents legislatures from declaring someone a criminal) protect individuals from overbearing government behavior and enable them to counteract it.

10. The American system of government calls for the resistance to tyranny.Fortunately, Americas founders erected bulwark upon bulwark against tyranny. But when all else fails, the Declaration of Independence makes clear that whenever any Form of Government becomes destructive of [inalienable rights], it is the Right of the People to alter or to abolish it, and to institute new Government.

This echoed both John Locke and George Mason, who inspired Jefferson. Locke argued that by violating natural rights, government officials forfeit the power the people had put into their hands and it devolves to the people, who have a right to resume their original liberty and instate a new government.

Likewise, The Virginia Declaration of Rights, drafted by George Mason, provided that the people have an indubitable, inalienable, and indefeasible right to reform, alter, or abolish a government that fails to serve and protect the people.

Yet common sense, and history time and again, prove that this last resort is available only where the people are armed. As former Judge Alex Kozinski of the U.S. Court of Appeals for the Ninth Circuit said, the simple truthborn of experienceis that tyranny thrives best where government need not fear the wrath of an armed people. Our own sorry history bears this out: Disarmament was the tool of choice for subjugating both slaves and free blacks in the South ... .

All too many of the other great tragedies of historyStalins atrocities, the killing fields of Cambodia, the Holocaust, to name but a fewwere perpetrated by armed troops against unarmed populations.

Judge Kozinski then calls the Second Amendment a doomsday provision, one designed for those exceptionally rare circumstances where all other rights have failed.

This is an extreme that should never be allowed to happen. A key to preventing such an extreme is having an armed populace who, by being armed, act as a deterrent to tyranny.

George A. Mocsary is a professor of law at the University of Wyoming College of Law and adjunct scholar at the Firearms Policy Coalition. Joseph Greenlee is the director of constitutional studies at the Firearms Policy Coalition.

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War in the Ukraine Has Strengthened the 2nd Amendment in the US – KLAW101

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If you held any doubts about the importance of the 2nd Amendment the war in Ukraine should serve as a prime example as to why the "right to keep and bear arms" is absolutely vital to the security and peace of the Nation. It may be too little too late, but Ukrainian President Volodymyr Zelensky made the announcement yesterday that all citizens who wish to arm themselves in defense of the country may do so.

More than that, the Ukrainian government/military would supply the weapons. At this time thousands upon thousands of Ukrainians are arming themselves and are ready to fight alongside their military in defense of their country. Had this right been protected by a constitution and in place prior to the invasion they would have been armed already and better prepared to defend their lives and country. By loosening the firearm laws in the country the Ukrainian government has at least given their citizens and country a fighting chance.

To those who doubted the meaning, intent, or reasoning of the 2nd Amendment what's happening in Ukraine should settle that argument. An armed citizenship is near impossible to conquer and control. In the United States, an enemy foreign or domestic would have to get through all of our military branches, all the reserves and guard units along with an armed populace in order to even occupy the country, much less conquer it.

It's frustratingly funny that people, "anti-gun" people, always remark that there's no need for citizens to have arms and that the 2nd Amendment is outdated. They continually say it's ridiculous to think that a private citizen with a gun could do much in defense of the country. Well, oddly enough that's exactly how our country began. A group of armed men tired of the tyranny they were living under got together and fought back, with arms. I'm sure the British at the time thought like our "anti-gun" crowd, and like them were dead wrong.

Within minutes of the Russian invasion, the Ukrainian government immediately put the word out about arming its citizens. So to those who constantly state that it's the government's job to protect and defend us, it clearly shows without us, it's a non-reality. Relying solely on others for protection is to be utterly defenseless and victim-bound. Without the means to protect yourself and others, you are at the mercy of those who would seek to do you harm and even those sworn to protect you. This is the heart of the Second Amendment.

The 2nd Amendment has never been about hunting, or really even self-defense. It's about having the means to protect our freedom, liberties, and the ability to use arms against tyranny, both foreign and domestic.

That's what it's all about and what we're seeing in Ukraine definitely affirms this, at least to those who are paying attention anyway. Hopefully, some lessons will be learned and those who in the past wished to eliminate or further restrict our rights to keep and bear arms will better understand the intent of our Founding Fathers, the architects of freedom and framers of our constitution had in mind when writing it.

Lastly, the Bill of Rights and U.S. Constitution DOES NOT grant rights. It recognizes and upholds the rights that were given to us at birth by our creator, which is why they're called "Inalienable Rights."

The primary purpose of the Consitution and Bill of Rights is to restrict the government's "infringement" of rights, which preexisted the documents in the first place. So any argument about changing any of the amendments in the Constitution is completely invalid. Our rights aren't given to us by the government, we were born with them. This means you CAN NOT take away what you haven't given!

While Oklahoma is well known for its beauty and friendly people there are a few places in the Sooner State you'll want to avoid. These are the most terrifying towns and scary cities in the state. It's not that they're bad places, or plagued with crime and other negative factors. The towns and cities below have one single thing in common. They all have active paranormal and supernatural phenomenons. From ghost stories to urban legends and tragic tales. A lot of these places are well known to those who live in Oklahoma and even all over the nation. If you're looking to get scared or do a little ghost hunting you can start with the list below.

When it comes to ghost tales and hauntings Lawton, Fort Sill has more than a few scary stories to tell. The most active hauntings and paranormal/supernatural occurrences that have been reported seem to be centered around downtown Lawton. If you've lived here a while I'm sure you've heard a few of these terrifying tales yourself. If not check out the photo gallery below of the dreadful downtown hauntings of Lawton, OK.

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War in the Ukraine Has Strengthened the 2nd Amendment in the US - KLAW101

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