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Daily Archives: February 19, 2022
The unmasking of Netanyahu’s politics – Haaretz
Posted: February 19, 2022 at 9:45 pm
The Calcalist business daily's report on police use of NSO spyware apparently only has negligible impact on former Prime Minister Benjamin Netanyahu's corruption trial. Netanyahu knows this, though he called for a state commission of inquiry on the issue anyway, and asked his supporters to fill Tel Aviv's Habima Square to underscore his demand.
What happened on the evening of the protest was nothing less than a sociological turning point. That morning, Netanyahu responded with humility to a letter that Supreme Court President Esther Hayut sent to Netanyahus Likud party colleague David Amsalem, as would be expected of a man from an established Ashkenazi family, a man who had always respected the judicial system and submitted to its authority until the criminal investigation was opened.
The assumption that he used Amsalem and then threw him under the bus after Amsalem lambasted the court, presumably at Netanyahus bidding, again shows how flawed and inadequate the reading of the Israeli reality is when it comes to status and social standing particularly by the left wing. Thats apparent from the reaction of Netanyahus supporters, who flooded social media with statements that they would stay away from the demonstration until Netanyahu backtracks on his decision to disassociate himself from Amsalem and his flattery of Hayut. Amsalem had taken the court to task claiming bias against Mizrahim.
Surprised? The public discourse over the courts racism is important to this segment of the public. The conflict between Amsalem and Hayut - in which Netanyahu naturally falls on the side to which he belongs socially, economically, ethnically and culturally reveals the bare bones of the story.
Let me tell you, someone with a Twitter profile picture of pro-Netanyahu commentator Jacob Bardugo tweeted, addressing Netanyahu. Next time that you contradict Dudi Amsalem, you lose 200 voters. I guarantee it. Your next tweet against our Mizrahi cell in Likud and you will remain alone and that also includes your nonsense over your fabricated [criminal] cases.
Do you feel the earthquake? Because at my house, the windowpanes are rattling, the books are falling from the shelves and the light fixture is swaying back and forth. The Twitter account holder publicly stated that the conspiracy to fabricate the cases against Netanyahu was nonsense, that his supporters dont believe him, but they have stuck with him because he suits their purposes in their war against the social elites and their dazzling whiteness.
This isnt an isolated anecdote. There have been similar tweets on a daily basis. And if one can judge from the turnout at Habima Square, a considerable number of people made good on their word to stay away.
Amsalem did his job. He attacked the court as part of a broader effort in which he throws Netanyahu crumbs by undermining public trust in government institutions, but Amsalem wants dialogue with Hayut not the Esther Hayut of the immigrant transit camp of her childhood, but with Hayut the Supreme Court president. He wants a serious conversation about ethnic identity and oppression and discrimination.
Netanyahus attitude toward the judicial system is related to his legal situation. Its possible that hes attempting to maintain good relations with Hayut because hes pursuing a plea bargain, but deep down, he really believes in the judicial system.
On the other hand, in the Likud Mizrahi cell, they think the claims regarding fabricated criminal cases and a government run by civil servants is rubbish, but theyre prepared to go along with Netanyahu as long as he understands whos the man (Amsalem). Those making fun of the new Mizrahi middle class that supports the millionaire former prime minister from Caesarea can see that this support comes with considerable limitations.
Amsalems attacks are wild, crude and damaging, but they keep the discourse on structural anti-Mizrahi bias alive. A nervous Netanyahu attempted to appease the crowd by tweeting that the under-representation ofMizrahi communitiesis a real and painful problem in Israel.But the rift has already been exposed.
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Affilka adds UK-licensed The Phone Casino to its affiliate marketing platform – Yogonet International
Posted: at 9:44 pm
Affilka by SOFTSWISS has signed a new partnership with The Phone Casino,the affiliate marketing platform announced on Tuesday. Resulting from the newly announced deal, The Phone Casino has now joined the list of operators that have partnered with SOFTSWISS platform.
The Phone Casino is one of Affilka partners to have received permission from the United Kingdom Gambling Commission (UKGC) to operate on the UK market. It is owned by Small Screen Casinos, an independent operator and a B2B provider of software and solutions to the gaming industry.
According to Affilka, as part of the cooperation, The Phone Casino will be able to strengthen its brand position and find new ways for promotion through its affiliate program, Small Screen Casinos. At the moment, The Phone Casino uses Profit and Loss tracking tools and reporting, but is planning to expand this list to include the payment systems in the near future.
"I am pleased to announce that The Phone Casino and Affilka are launching the Small Screen Casinos affiliate program, which will be a great and effective tool for casino development and growth, said Anastasiya Baravaya, Product Owner at Affilka. Affilka offers user-friendly and easy-to-use affiliate and player solutions. With our platform, The Phone Casino will be able to analyze player behavior and use this knowledge to drive their business.
Affilka will leverage its status as one of the leading solutions for affiliate management in the iGaming market as part of the partnership, SOFTSWISS explains. The platform helps promote casinos, sportsbooks and poker rooms with affiliate programs that are customized for each client.
This, in turn, helps organize affiliate activities based on business requirements, collect detailed player statistics, and optimize marketing costs. SOFTSWISS platform enables operators to manage affiliate partners across multiple brands, and permits to analyze player ROI from partners.
Affilka by SOFTSWISS is set to utilize a series of tools in the partnership. These include built-in payment processing (Neteller, Skrill, Cryptoprocessing and Bank transfer), and detailed partner and player reports available within the affiliate program interface in CSV, JSON and XML formats as well as via the API.
The platform further provides simple management of banners and affiliate landings and a flexible commission constructor (RevShare, Hybrid, CPA and CPL), SOFTSWISS explains. Affilka also features many postbacks options, and a single affiliate program for multiple brands and products.
"We are proud to announce the evolution of our bespoke platform, by integrating with SOFTSWISS and Affilka. SSC is now able to offer affiliates the chance to participate and promote our product in multiple markets, commented Taj Ratta, Co-Founder of Small Screen Casinos Ltd. The Affilka platform gives our partners transparency and further allows them to leverage SSC's successes and by giving them a real competitive edge when promoting SSC's brands.
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Legalized sports betting to soon be legal at Potawatomi Hotel & Casino – WISN Milwaukee
Posted: at 9:44 pm
Sports betting may soon be legal at Potawatomi Casino.Gov. Tony Evers and Forest County Potawatomi Chairman Ned Daniels Jr. signed a historic compact amendment Friday allowing casinos and affiliate locations in Wisconsin operated by the Forest County Potawatomi to offer event wagering on sports and non-sports events. The signed amendment was sent to the U.S. Department of Interior where it will undergo a 45-day review. It opens the door for the Forest County Potawatomi to begin offering sports and event wagering at its two casinos and adjacent lands in the Menominee Valley and Forest County. The Forest County Potawatomi plans to open a sportsbook venue at the Potawatomi Hotel and Casino in Milwaukee by the end of 2022. In addition, the amendment extends the term of the current compact to 2061. This compact amendment comes shortly after Evers signed similar compacts with the Oneida Nation and the St. Croix Chippewa Indians of Wisconsin.
Sports betting may soon be legal at Potawatomi Casino.
Gov. Tony Evers and Forest County Potawatomi Chairman Ned Daniels Jr. signed a historic compact amendment Friday allowing casinos and affiliate locations in Wisconsin operated by the Forest County Potawatomi to offer event wagering on sports and non-sports events.
The signed amendment was sent to the U.S. Department of Interior where it will undergo a 45-day review.
It opens the door for the Forest County Potawatomi to begin offering sports and event wagering at its two casinos and adjacent lands in the Menominee Valley and Forest County.
The Forest County Potawatomi plans to open a sportsbook venue at the Potawatomi Hotel and Casino in Milwaukee by the end of 2022. In addition, the amendment extends the term of the current compact to 2061.
This compact amendment comes shortly after Evers signed similar compacts with the Oneida Nation and the St. Croix Chippewa Indians of Wisconsin.
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Legalized sports betting to soon be legal at Potawatomi Hotel & Casino - WISN Milwaukee
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Whats happening in South Jersey this weekend and beyond (Feb. 18-24) – nj.com
Posted: at 9:44 pm
WHATS GOING ON? Here is a small sample of area happenings you may want to check out in the coming days. Check ahead, for some events are being postponed or canceled over COVID-19 concerns. Also visit venues websites to learn about COVID-19 safety precautions in effect.
Flamenco Vivo Carlota Santana is scheduled to perform Friday, Feb. 18, at Stockton University, Stockton Performing Arts Center in Galloway.Stockton University
ONGOING
ATLANTIC CITY MOVE 1976, paintings by Melvin Irons, through Feb. 28. Memorial Quilt Project and Paintings by Melvin Irons, through Feb. 27. African American Heritage Museum of Southern New Jersey, Noyes Arts Garage, 2200 Fairmount Ave. aahmsnj.org, 609-892-0439.
Peter Turnley, through March 14. Noyes Arts Garage, Stockton University, 2200 Fairmount Ave. artsgarageac.com, 609-626-3805.
COLLINGSWOOD Tom Gaines Solo Exhibit, through Feb. 25. Perkins Center for the Arts, 30 Irvin Ave. perkinscenter.org, 856-833-0009.
GALLOWAY Wood Engravers Network Fourth Triennial, 65 contemporary relief engravings by artists from Belgium, Bulgaria, Canada, England, Finland, Ireland, Latvia, Taiwan, Ukraine and the United States, through April 5. Stockton University, Art Galleries, Vera King Farris Drive in Pomona. stockton.edu, 609-652-4566.
HAMMONTON Drew Griffiths, through March 18. Landscapes of the Mind, Regional Center for Women in the Arts exhibit, through June 3. Noyes Gallery at Kramer Hall, Stockton University, 30 Front St. noyesmuseum.org, 609-626-3420.
MILLVILLE Society of NJ Artists, atrium gallery exhibit, through March 12. Works by Janis Quiggle and Carol Hiemenz, Asssociate Artist Alcove display, through March 12. In Your Dreams, main gallery exhibit, through March 12. Affiliate Artist Member Annual Show, Witt gallery exhibit, through March 12. Third Friday, receptions for current exhibits, 11 a.m.-8 p.m. Feb. 18. Riverfront Renaissance Center for the Arts, 22 N. High St. rrcarts.com, 856-327-4500.
MOORESTOWN Looking Up, 41st annual juried photo show, through Feb. 25. Perkins Center for the Arts, 395 Kings Highway. perkinscenter.org, 856-235-6488.
FEB. 19
ATLANTIC CITY Jo Koy, 7 p.m., Borgata Hotel Casino and Spa, Event Center, 1 Borgata Way. Sold out. theborgata.com, 866-900-4849.
FEB. 18
GALLOWAY Flamenco Vivo Carlota Santana, 7:30 p.m., Stockton University, Stockton Performing Arts Center, 101 Vera King Farris Drive. $10-$32. stocktonpac.org, 609-652-9000.
FEB. 19
GLASSBORO AXIS Dance Company, Roots Above Ground choreographed by former artistic director Marc Brew and Flora HereAfter How Flowers Survive choreographed by 2020 Pina Bausch Fellow, Neve Mazique-Bianco., 8 p.m., Rowan University, Pfleeger Concert Hall, 201 Mullica Hill Road. $10-$20. ci.ovationtix.com/35360, 856-256-4545.
MOORESTOWN Scott Glassman, talk and book signing with author of A Happier You A Seven-Week Program to Transform Negative Thinking into Positivity and Resilience, 1 p.m., Barnes and Noble, 1311 Nixon Drive. barnesandnoble.com, 856-608-1622.
FEB. 18
ATLANTIC CITY Reba McIntire, Brittney Spencer, 8 p.m., Borgata Hotel Casino and Spa, Event Center, 1 Borgata Way. $96-$190. theborgata.com, 866-900-4849.
The Life and Music of George Michael, 9 p.m., Borgata Hotel Casino and Spa, Music Box Theater, 1 Borgata Way. $40-$120. theborgata.com, 866-900-4849.
On Kentucky Avenue, the Club Harlem Revue, 8 p.m., also Feb. 19, 4 and 8 p.m. Hard Rock Hotel and Casino, Sound Waves, 1000 Boardwalk. $25. hardrockhotelatlanticcity.com, 800-736-1420.
BERLIN Rubber Soul/Revolver Front to Back, Beatles tribute, 8 p.m., also Feb. 19, 8 p.m. The Vault Concert Stage, Victor Records Museum, 250 S. White Horse Pike. $29. victorrecords.com, 844-802-2557.
HI-NELLA GruvTyme, 7:30-10 p.m., Wilsons Restaurant & Live Music Lounge, 709 Warwick Road. $20. wilsonslivemusic.com, 856-258-5829.
PITMAN The Hit Men, 8 p.m., Broadway Theatre of Pitman, 43 S. Broadway. $35. thebroadwaytheatre.org, 856-384-8381.
VINELAND Songs in the Attic, Billy Joel tribute, 8 p.m., Landis Theater, 830 E. Landis Ave. $20. thelandistheater.com, 856-794-4100.
FEB. 19
ATLANTIC CITY Come Fly With Me, Frank Sinatra tribute with Michael Martocci and 20-piece orchestra, 8 p.m., Harrahs Atlantic City, Concert Venue, 777 Harrahs Blvd. $39-$79. ticketmaster.com, 609-441-5000.
Kool and the Gang, 8 p.m., Ocean Casino Resort, Ovation Hall, 500 Boardwalk. $35-$75. theoceanac.com, 866-506-2326.
COLLINGSWOOD Dave Mason, 8 p.m., Scottish Rite Auditorium, 315 White Horse Pike. $39.50-$85. scottishriteauditorium.com, 856-858-1000.
GLASSBORO Violist Amadi Azikiwe, in-person guest faculty spotlight concert, 5:30 p.m., Rowan University, Boyd Recital Hall, 201 Mullica Hill Road. Free but reservations required. ci.ovationtix.com/35360, 856-256-4000.
HI-NELLA Reflexx, 7:30-10 p.m., Wilsons Restaurant & Live Music Lounge, 709 Warwick Road. $20. wilsonslivemusic.com, 856-258-5829.
PILESGROVE John Keith Davis, free fireside gospel folk concert, 2:30-3:30 p.m., Four Seasons Campground Lodge, 158 Woodstown Daretown Road. pantinghart.org, 856-935-6376.
FEB. 20
ATLANTIC CITY 80s Live, 4 p.m., Hard Rock Hotel and Casino, Sound Waves, 1000 Boardwalk. $24. hardrockhotelatlanticcity.com, 800-736-1420.
70s Love Jam, 7 p.m., Hard Rock Hotel and Casino, Etess Arena, 1000 Boardwalk. $59-$250. hardrockhotelatlanticcity.com, 800-736-1420.
FEB. 21
GLASSBORO Rowan University Percussion Ensemble, in-person and live-streamed concert, 7:30 p.m., Rowan University, Pfleeger Concert Hall, 201 Mullica Hill Road. $5-$10. ci.ovationtix.com/35360, 856-256-4545.
FEB. 22
GALLOWAY The Kings Singers, 7:30 p.m., Stockton University, Stockton Performing Arts Center, 101 Vera King Farris Drive. $10-$35. stocktonpac.org, 609-652-9000.
GLASSBORO Rowan University Symphonic and Concert Bands, in-person and live-streamed concert, 7:30 p.m., Rowan University, Pfleeger Concert Hall, 201 Mullica Hill Road. $5-$10. ci.ovationtix.com/35360, 856-256-4545.
MILLVILLE Hot Peas N Butter, multicultural family music band, 10:30 a.m., also Feb. 22, 12:30 p.m. Levoy Theatre, 126-130 N. High St. $10. levoy.net, 856-327-6400.
FEB. 23
GLASSBORO Lyric Soprano Marian Stieber, in-person and live-streamed faculty spotlight concert, 7:30 p.m., Rowan University, Boyd Recital Hall, 201 Mullica Hill Road. Free but reservations required. ci.ovationtix.com/35360, 856-256-4000.
FEB. 24
GALLOWAY Stockton Chamber Players, 7:30 p.m., Stockton University, Alton Auditorium, Jim Leeds Road in Pomona. $10-$12. stockton.edu, 609-652-9000.
HI-NELLA Lovey, 7:30-10 p.m., Wilsons Restaurant & Live Music Lounge, 709 Warwick Road. $20. wilsonslivemusic.com, 856-258-5829.
FEB. 22
ATLANTIC CITY Harlem Globetrotters, 7 p.m., Boardwalk Hall, 2301 Boardwalk. $20-$80. boardwalkhall.com, 800-745-3000.
FEB. 18 HADDONFIELD Songs for a New World, Jason Robert Brown musical, 8 p.m., also Feb. 19, 3 and 8 p.m. Haddonfield Plays and Players Performing Arts Center, 957 E. Atlantic Ave. at Crows Woods. $30. haddonfieldplayers.com, 856-429-8139.
MILLVILLE The Great Gatsby, stage adaptation of the F. Scott Fitzgerald novel, 8 p.m., also Feb. 19, 2 and 8 p.m.; Feb. 20, 3 p.m. Levoy Theatre, 126-130 N. High St. $12-$15. levoy.net, 856-327-6400.
OAKLYN Greater Tuna, comedy with two actors portraying various citizens of a small town, 8 p.m., also Feb. 19, 8 p.m.; Feb. 20, 2 p.m.; Feb. 23, 7:30 p.m. Ritz Theatre, 915 Whitehorse Pike. $27. ritztheatreco.org, 856-858-5230.
FEB. 19
OAKLYN Sleeping Beauty, Ritz Kidz production, 10 a.m., also Feb. 19, 1 p.m. Ritz Theatre, 915 Whitehorse Pike. $10. ritztheatreco.org, 856-858-5230.
PITMAN Jungle Book, family musical, 10 a.m., also Feb. 19, 1 p.m. Broadway Theatre of Pitman, 43 S. Broadway. $10. thebroadwaytheatre.org, 856-384-8381.
FEB. 24
GLASSBORO Our Lady of 121 Street, student production of Stephen Adly Guirgis comedy about a stolen corpse from a funeral home, 8 p.m., Rowan University, Tohill Theatre, Mullica Hill Road. $10-$15. ci.ovationtix.com/35360, 856-256-4030.
FEB. 19
GALLOWAY Cirque Zuma Zuma, acrobatic production, 2 p.m., Stockton University, Stockton Performing Arts Center, 101 Vera King Farris Drive. $10-$32. stocktonpac.org, 609-652-9000.
Sea Turtle Recovery Charity Luncheon, 11:30 a.m., JDs Pub & Grille, 45 S. New York Road in Smithville. $35. eventbrite.com, 609-667-4076.
FEB. 24
WEST DEPTFORD Ned Hector A Black American Revolutionary War Soldier, in-library Black History Month historical portrayal by Noah Lewis, 1 p.m. Feb. 24, West Deptford Free Public Library, 420 Crown Point Road. Registration required. westdeptford.lib.nj.us, 856-845-5593.
ONGOING
GLASSBORO Pet Supply Drive, drop-off site for donations for Gloucester County Animal Shelter, through February, Traditions of Cross Keys, 3152 Glassboro-Cross Keys Road. traditionsofcrosskeys.com, 856-307-2100.
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Patrick OShea may be reached at poshea@njadvancemedia.com.
Send event information to events@starledger.com or submit online at nj.com/myevent
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Whats happening in South Jersey this weekend and beyond (Feb. 18-24) - nj.com
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Anti-ageing pills are real, and some of us are taking them without knowing it – BBC Science Focus Magazine
Posted: at 9:42 pm
Picture the scene. After a routine blood test, you visit your GP for the results. Its all good, says the doctor reassuringly. The only problem is that youre getting older. Then, with a flourish of the prescription pad, the doctor adds: But I can help you with that. Take these tablets. Theyll slow the ageing process and help you to stay healthy. Oh, and they might just make you live longer too.
A drug that extends your life, slows ageing and staves off the ravages of old age, including frailty and disease? It sounds too good to be true, and yet, an increasing weight of evidence suggests not just that these drugs are within reach, but that they may already be here.
Some can be found on the shelves at your local health store, while others are drugs for conditions such as diabetes and cancer that are being repurposed. Animal studies have demonstrated their potential, and now clinical trials are beginning to assess if their promise holds true in humans. If it does, those who are middle-aged now could become the first generation to benefit from their use. Imagine an 80-year-old with the biology and get up and go of someone 30 years younger. How joyful not to have to act your age!
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In the last couple of decades, the science of anti-ageing has moved from science-fiction into academically rigorous, evidence-based, peer-reviewed science. Its not about achieving immortality, having your brain cryogenically preserved or any of the other outlandish propositions that have been mooted.
There are a lot of people out there who sell you snake oil and tell you that youll live forever, and then when you die, nobody sues them, says Dr Nir Barzilai, director of the Institute for Ageing at the Albert Einstein College of Medicine in New York. Instead, its about improving what scientists call the healthspan, or the number of years that people can live well without disease. Extending the lifespan could be a fortuitous side effect, as could the ramifications for the economy.
Currently, 80 per cent of the worlds adults aged 65 or over have at least one chronic illness, while 68 per cent have two or more. The human suffering is huge, and in the next 30 years, the number of over-65-year-olds is projected to double to 1.5 billion. This will be costly.
If we had a drug that adds even one or two healthy years onto the lifespan, it would have trillions of dollars of effect on the world economy, because people would be productive for longer and they wouldnt have all these morbidities that cost our healthcare systems so much, says Jim Mellon, chairman of the longevity company Juvenescence.
Staving off physical and mental decline is vital if were expected to live longer Getty Images
Its no coincidence that age is the biggest risk factor for illnesses such as cancer, cardiovascular disease and neurodegeneration. The ageing process involves a whole raft of biological changes that drives their development. Scientists call these changes hallmarks and around nine have been identified, including the accumulation of genetic mutations, the unravelling of chromosomes and the impaired ability of tiny cellular power packs, called mitochondria, to function.
According to the theory, if you can correct these problems, you wont just slow down ageing, youll also prevent or defer many of the diseases that are associated with old age.
In December 2021, researchers from the University of the Chinese Academy of Sciences in Shanghai revealed that a natural compound found in grape seeds could prolong the lifespan of old mice by 9 per cent, and make them physically fitter too. The compound, called procyanidin C1, works by targeting another of the hallmarks of ageing: the build-up of tired, worn-out cells that are described as senescent.
In our younger years, the immune system clears senescent cells from the body before they can cause a problem, but as we age and our immune system falters, the cells get to hang around, secreting inflammatory molecules that injure the surrounding tissue.
Its like a fire that spreads, says Ming Xu, who studies senescence at the University of Connecticuts Centre on Ageing. Its a very small population of cells, but they have a very large and very damaging effect. Drugs that seek out and kill these senescent cells, known as senolytics, are among the most promising anti-ageing therapies.
Xu and colleagues have shown that when small numbers of senescent cells are transplanted into mice, it ages them. Then when the same mice are treated, not with procyanidin C1, but with a cocktail of two different senolytic drugs, the rogue cells are destroyed and the mice become more robust. They develop stronger muscles, become more active and live longer. The same results are seen in mice that have aged naturally.
The ability of our mitochondria, essentially the batteries of our cells, declines as we age Getty Images
Its all the more impressive because the mice received the drugs very late in life, when they were already two years old. Its the equivalent of a person beginning treatment when they are 70 or 80, and then having their healthy lifespan extended by five to six years, says Xu.
Also encouraging is the fact that these drugs are already known to be safe for human use. Quercetin, which is a plant pigment found in many fruits and vegetables, is sold as a dietary supplement, while dasatinib is approved for use as a blood cancer drug.
Further animal studies have shown that senolytic drugs can delay, prevent or ease more than 40 diseases, including cancers and various disorders of the heart, liver, kidney, lung, eye and brain. Preliminary studies in humans show that they reduce the number of senescent cells, curb inflammation and alleviate frailty, and now dozens of clinical trials are underway to assesstheir impact on various conditions, including diabetes, arthritis and Alzheimers disease.
All of these trials will yield vital information, but if a senolytic or any other drug is ever to be used as a genuine anti-ageing therapy, itll need to pass muster in the human equivalent of Xus mouse study. As well as testing these drugs in people who already have disease as is happening in the current clinical trials they also need to be rigorously tested in healthy people who are ageing naturally.
Its a conceptual no-brainer and should be straightforward, save for a couple of problems. The first is that humans take decades to age, a predicament that makes the requisite trials both lengthy and expensive.
One potential solution to this problem, currently under investigation, is to use molecular proxies or biomarkers of the ageing process. These are subtle changes, such as the addition of certain chemical groups to DNA, that occur across smaller time frames and are thought to be indicative of the broader ageing picture.
Another option is to turn to mans best friend. Dogs age around seven times faster than humans, and experience many of the same age-related diseases and declines. They also share our homes and many of the same environmental influences that contribute to ageing. In short, theyre an excellent model of the ageing process, and are willing to help out in exchange for treats and belly rubs.
The different proliferations of keratinocytes, a type of skin cell, in an old mouse (top) and a young mouse (bottom) Birgit Ritschka/Research Institute of Molecular Pathology Vienna
As part of the Dog Aging Project in the US, 500 canines are helping to assess the worth of another putative anti-ageing treatment, called rapamycin. Rapamycin also targets senescent cells, as well as several of the other hallmarks of ageing.
Relatively large doses are given to transplant patients to help prevent organ rejection, but in small doses its been shown to prolong life in yeast, worms, flies and mice. The dogs will be followed for up to a decade and if rapamycins promise holds true, those who receive the therapy could have their lives extended by up to four human years (or 28 dog years).
The second problem with arranging the requisite human studies is less practical and more attitudinal. According to the current medical paradigm, ageing is not something that needs to be treated. Along with hangovers and nuisance phone calls, ageing is viewed as a grim inevitability of life.
If the US Food and Drug Administration (FDA) and other medical regulators are ever to approve a drug for ageing, they would first need to recognise that ageing is a preventable condition that can be targeted therapeutically. We dont want to call ageing a disease, says Barzilai. The people we want to help dont want us to call them sick, but ageing does need to be officially recognised as an indication that is treatable.
So Barzilai has found a way around the conundrum. His focus is on another potential anti-ageing drug, called metformin. Metformin is a cheap and successful medicine. Every day, millions of people take it to control their type 2 diabetes, but in 2016, Barzilai suggested it could be used to slow ageing.
Dogs age in similar ways to humans but considerably faster, so are useful proxies Shutterstock
Key to his argument is a 2014 UK clinical trial involving over 150,000 people, which revealed that diabetics taking metformin live longer than non-diabetics who dont, and a growing number of separate studies that demonstrate metformins ability to prevent specific age-related disorders. Taken together, these studies hint that metformin may be able to improve the healthspan, but they dont quite nail it. Whats needed is a clinical trial that ties all these loose ends together in a single, well-designed study. Enter, the Targeting Aging with Metformin (TAME) trial.
Barzilai and colleagues are recruiting 3,000 adults, aged 65 to 80, who dont have diabetes, to receive either metformin or a placebo over a four-year period. During this time, the team will monitor age-related biomarkers and the time it takes for each of the patients to develop a major age-related disease, such as dementia or stroke.
Instead of looking at the ability of metformin to delay a single age-related disease, as the other trials have done, this study will assess the drugs capacity to delay the onset of age-related disease in general. It will show if metformin can increase the healthspan.
If the trial succeeds, its effects could be far-reaching. TAME has the power to prove that ageing really is something that can be targeted and treated with drugs. This, in itself, will be a major paradigm shift. We hope it will inspire the FDA to make ageing an indication and provide a template for other biotech companies to do similar studies, says Barzilai.
While other scientists pursue different anti-ageing strategies, such as gene therapy or tissue transplants, taking tablets is so much simpler. Metformin could become the first authorised anti-ageing drug with the ability to not just prolong life, but to prolong a healthy life. Then after metformin, other anti-ageing drugs could follow. Instead of treating each age-related medical condition separately, as currently happens, its possible to imagine a future where these conditions are treated together, by targeting multiple hallmarks of ageing.
Just as statins are doled out today to lower cholesterol, and prevent strokes and heart disease, so too anti-ageing medicines or gerotherapeutics could be prescribed to prevent the diseases of old age. Based on the results of a blood test, which could indicate how fast youre ageing and which diseases youre prone to, a clinician might prescribe one or more anti-ageing drugs.
Dr Nir Barzilai and his team are investigating ways of increasing human healthspans Albert Einstein College of Medicine
Metformin, rapamycin, quercetin, dasatinib and other as-yet-unidentified anti-ageing drugs could all be part of the picture. It would mark a shift away from the prevailing medical model, where diseases are treated reactively after symptoms have occurred and suffering has set in, to a preventative model of care, where patients are monitored proactively and future diseases are averted.
With a handful of promising anti-ageing drugs already in existence, ageing has never looked so treatable, and yet, theres just one final problem. Clinical trials dont come cheap, so the question is, who pays?
Government funding agencies seemingly arent keen to invest in the anti-ageing area. Regulators dont tend to fund studies of drugs that are already on the market, and the pharmaceutical industry wont cough up for trials of drugs that are generic, cheap or off-patent, with no profit margin.
The 30 or so bona fide anti-ageing companies that exist are more interested in developing their own proprietary therapies than readily accessible drugs such as metformin or quercetin. Until additional funding can be found, this means that safe, affordable drugs with the potential to slow ageing and extend the healthspan are not being properly explored. Meanwhile, the people who need them most are growing old waiting.
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What Will The Meta Future Look Like By CoinQuora – Investing.com
Posted: at 9:42 pm
If you had the luxury of choice to change anything about yourself, would you?
People have long desired to change their appearance, fulfill their dreams, and travel to the most remote of regions. Sadly, these desires always seemed too far out of reach for most people. Limitations with technology, medicine, or social norms made it unavailable. It was only for the realm of the privileged.
That is until we formed the early digital worlds through video games. Titles such as The Sims allowed us to create, dress, and control the lives of virtual characters. Digital worlds showed us the potential of reflecting real life into the virtual realm.
A dozen or so years since the release of The Sims, and now we have the concept of the Metaverse the digital equivalent of the real world. This concept has captured the imagination of technology giants and the worlds largest corporations.
In fact, Steven Spielberg visualized his version of the metaverse in the 2018 film Ready Player One. Despite looking bleak, it outlined the potential of the metaverse. One that promised enormous profits, fame, and immortality.
Similarly, Facebooks Mark Zuckerberg changed his company name to Meta as a show of solidarity towards the Metaverse concept.
Other companies have followed suit from various industries like fashion, wearables, jewelry, and FMCG. Industries have realized the change in priorities of consumers who now value intangible goods as much as tangible ones.
Generation Z is the section of consumers most immersed in the digital world after the Millennials. They are the greatest force on the internet setting directions and trends that shape the future global digital market of goods and services. For example, the gaming industry developed progressive subscriptions; Pay 2 Win models; and the buying and selling of virtual items for cash.
However, in this new generation of intangible goods, scammers still exist to take money away from innocents. Thats why there has been a rise in the prioritization of cyber-security in recent years.
One such way to ensure security is through NFT technology, which allows for safe and automated transfer of value from the real world to the metaverse. The technology confirms sales by a unique certificate based on blockchain technology. As a result, art, record collections, shoes, purse, or any other material may be worth as much in the metaverse as in the real world.
Today, the worlds largest companies are changing their business strategies and multi-billion fortunes are being created as we speak.
Eventually, we might all find it difficult to define the difference between virtual and reality.
Radosaw Krzycki investor, creator of IT projects and solutions based on blockchain technology. Founder of the go2NFT project, operational director (COO) of the Skey.network blockchain platform, designer and creator of innovative NFT blockchain solutions dedicated to brands and corporations.
Disclaimer: CoinQuora does not endorse any content or product on its page. While we aim to provide you with all relevant information that we could obtain, readers are encouraged to do their own research before taking any actions and bear full responsibility for their decisions. Please note that this article does not constitute investment advice.
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AI-generated faces are now more trustworthy than real ones – Fast Company
Posted: at 9:40 pm
You might be confident in your ability to tell a real face from one created using artificial intelligence. But a new study has found that your chance of choosing accurately would be slightly better if you just flipped a coinand you are more likely to trust the fake face over the real one.
Published in the Proceedings of the National Academy of Sciences, the study was conducted by Hany Farid, a professor at the University of California, Berkeley, and Sophie J. Nightingale, a lecturer at Englands University of Lancaster.
Farid has been exploring synthetic imagesand how well people can tell them apart from the real onesfor years. He initially focused on the rise of computer-generated imagery. But the mediums path has accelerated in recent years as deep-learning-based neural networks known as GANs (generative adversarial networks) have become more sophisticated at generating truly realistic synthetic images. If you look at the rate of improvement of deep fakes and [GANs], its an order of magnitude faster than CGI, he says. We would argue that we are through the uncanny valley for still faces.
The problems with such realistic fakes are manifold. Fraudulent online profiles are a good example. Fraudulent passport photos. Still photos have some nefarious usage, Farid says. But where things are going to get really gnarly is with videos and audio.
Given the speed of these improvements, Farid and Nightingale wanted to explore if faces created via artificial intelligence were able to convince viewers of their authenticity. Their study included three experiments aimed at understanding whether people can discern a real face from a synthetic one created by Nvidias StyleGAN2. After identifying 800 images of real and fake faces, Farid and Nightingale asked participants to look at a selection of them and sort them into real and fake. Participants were correct less than half the time, with an average accuracy of 48.2%.
A second experiment showed that even giving participants some tips on spotting AI-generated faces and providing feedback as they made their decisions didnt drastically improve their deciphering ability. Participants identified which face was real and which was fake with 59% accuracy, but saw no improvement over time. Even with feedback, even with training trying to make them better, they did slightly better than chance, but theyre still struggling, Farid says. Its not like they got better and betterbasically it helps a little bit, and then it plateaus.
The difficulty people had spotting faces created by artificial intelligence didnt particularly surprise Farid and Nightingale. They didnt anticipate, however, that when participants were asked to rate a set of real and fake faces based on their perceived trustworthiness, people would find synthetically generated faces 7.7% more trustworthy than real onesa small but statistically significant difference.
We were really surprised by this result because our motivation was to find an indirect route to improve performance, and we thought trust would be thatwith real faces eliciting that more trustworthy feeling, Nightingale says.
Farid noted that in order to create more controlled experiments, he and Nightingale had worked to make provenance the only substantial difference between the real and fake faces. For every synthetic image, they used a mathematical model to find a similar one, in terms of expression and ethnicity, from databases of real faces. For every synthetic photo of a young Black woman, for example, there was a real counterpart.
Though the type of images GANs can convincingly create at the moment are still limited to passport-style photos, Nightingale says the deceptions pose a threat for everything from dating scams to social media.
In terms of online romance scams, these images would be perfect, she says. [For] things like Twitter disinformation attacks, rather than having a default egg image, you just take one of these images. People trust it, and if you trust something, youre probably more likely to share it. So you see how these types of images can already cause chaos.
So how do we protect against people using synthetic images for nefarious means? Farid is a champion of an approach called controlled capture, which is being built out by companies like TruePic and the Coalition for Content Provenance and Authentication. The technology captures metadata related to time and location for any photo taken within an app that has built-in camera function.
I think the only solution is to authenticate at the point of recording, using a controlled capture-type of technology, he says. And then, anything that has that, good; anything that doesnt, buyer beware. I think this [solution] is really going to start to get some traction, and my hope is in the coming years, we start taking trust and security more seriously online.
Beyond synthetic still images, the study comes as the world of synthetic media is growing. Synthesia, an Australian company, closed a $50 million series B round in December for AI avatars used in corporate communications; and London-based Metaphysic, the company behind viral deep fakes of Tom Cruise, raised $7.5 million earlier this year. As these technologies continue to improve and change whats possible to do with AI, Nightingale says researchers and companies will have to think seriously about the ethics involved.
If the risks are greater than the benefits of some new technology, should we really be doing it at all? she asks. First of all, should we be developing it? And second, should we be uploading it to something like Github, where anyone can just get their hands on it? . . . As we see, once its out there, we cant just take it back again because people have downloaded it, and its too late.
Answers1. Fake2. Real3. Real4. Fake
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DeepMind Teaches AI to Assist With Nuclear Fusion Experiments – PCMag
Posted: at 9:40 pm
DeepMind wants to use artificial intelligence to help scientists experiment with nuclear fusion, which it believes is a contender for "a source of clean, limitless energy" here on Earth.
The company says it collaborated with the Swiss Plasma Center at the EPFL technical university in Switzerland "to develop the first deep reinforcement learning (RL) system" devoted to the tools researchers are using to assess the nuclear fusion's viability as an energy source.
That reinforcement learning system was designed to "autonomously discover how to control" a tokamak, which DeepMind says is "a doughnut-shaped vacuum surrounded by magnetic coils" that is "used to contain a plasma of hydrogen that is hotter than the core of the Sun."
It turns out that experimenting with something hotter than the Sun can be difficult. EPFL says that if a tokamak's settings aren't carefully managed the plasma within "could collide with the vessel walls and deteriorate." So researchers have to run their experiments in simulators first.
But those simulators can be hard to use, too, not least because of time constraints. DeepMind says that "plasma simulators are slow and require many hours of computer time to simulate one second of real time." That's hardly ideal for scientists racing to investigate nuclear fusion.
It's also where AI comes in. DeepMind and the Swiss Plasma Center published a study in Nature describing a system that's said to have allowed them to create "controllers that can both keep the plasma steady and be used to accurately sculpt it into different shapes" for further research.
"Similar to progress weve seen when applying AI to other scientific domains," DeepMind says, "our successful demonstration of tokamak control shows the power of AI to accelerate and assist fusion science, and we expect increasing sophistication in the use of AI going forward."
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An interest in AI led this student to a job at Google – University of Georgia
Posted: at 9:40 pm
Foundation Fellow Nathan Safir is happiest when working on a complicated problem
As Nathan Safir was finishing up his masters in artificial intelligence at the University of Georgia, he had a big decision to make: Did he want to accept the Marshall Scholarship to pursue a Ph.D. in computer science in England or accept an offer to start work at Google this summer?
Safir, a Foundation Fellow, applied his problem-solving brain to the decision.
Mostly I tried to simplify it into a decision of Am I more excited to work now or am I more excited to go to grad school now? said Safir, who has a B.S. in computer science with a minor in geography.
Safir in the Institute for Artificial Intelligence in the Boyd Research and Education Center. (Photo by Chamberlain Smith/UGA)
Google was the winner. For now. Safir hopes to get his Ph.D. in artificial intelligence sometime in the future.
Whatever way he gets there, the end goal is the same he wants to work in artificial intelligence. Whether its working on a new cool application, existing AI methods, or actually doing the research, Id really love to work somewhere in that space, said Safir.
This flexibility will serve Safir well at Google, because he doesnt yet know what hell be doing at the company when he arrives in California this August. Theyll start team matching closer to my start date, said Safir. All I know is that Ill be in the Bay Area and possibly working on the Google Ads team.
During a Google internship in summer 2021, he worked with the Cloud AI team.
UGA has helped him find his passion for AI in several ways. One was a difficult math class his first year in college. I was a super eager freshman, so I took Math 3500. Its notorious for being very tough, and it was. I was glad I took it, but I realized I was less interested in the proof-based rigorous mathematics.
Nathan Safir outside of the Institute for Artificial Intelligence in the Boyd Research and Education Center. (Photo by Chamberlain Smith/UGA)
He decided to pick up machine learning instead. It presented an interesting way to use mathematical thinking and be able to think creatively.
Also helpful in guiding his path was UGAs Foundation Fellowship, a merit-based scholarship based in the Jere W. Morehead Honors College that is awarded to between 20-25 high school seniors out of 1,200 applicants. Its the reason Safir, who grew up in Kansas City, Missouri, ultimately chose UGA out of his ranked list of 13 potential schools.
He said he most appreciates the travel opportunities, although theyve been a bit truncated during the COVID years, and the people hes met along the way. The network of people you can talk to about careers or cool places you could work that type of thing was super helpful for me trying to imagine what I wanted to do in the future. Safir said he interacts with staff, peers and friends from the Fellowship on a daily basis.
Safirs gateway into programming was a documentary he saw in middle school on Mark Zuckerberg. It said he learned C++ from a book when he was about my age so I checked out the same C++ book from the library. I dont think I picked it up as quickly as he did, but that was the beginning of me trying to learn programming.
Ive been into math and quantitative problem solving since I was really young. Programming was just an extension of that logical problem-solving, he said.
Safir is a down-to-earth, well-rounded person who can move between playing in local Monday pick-up hockey games, coaching Athens Youth Hockey and working on his tennis game, to high-level problem-solving. But hes happiest when he has a tough question to work on.
My thesis is working on a theoretical problem of how to extend an architecture called variational autoencoders to work with both labeled and unlabeled data, he said. My lab, led by Dr. Quinn of the CS department, is at the intersection of biomedical imaging and artificial intelligence. Its a theoretical problem inspired by a real-world problem. Its an especially open fieldI feel like there are a million different things you can work on. Im just happy I can be a part of it.
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Medicine Meets Big Data: Clinicians Look to AI for Disease Prediction, Prevention – University of Virginia
Posted: at 9:40 pm
From music streaming platforms to social media feeds and search engines, algorithms are used behind the scenes to tailor services to the unique preferences of individuals. Though the use of algorithms has been explored in health care since the origins of artificial intelligence, new strides in deep learning methods over the last decade are allowing clinicians to go after mass amounts of data that were previously inaccessible, transforming how doctors and clinical researchers detect, diagnose and treat disease.
In addition to higher data-computing capacities and advanced algorithms, clinicians can now input data through written and spoken words rather than only quantitative lab and imaging results. As they talk with patients about subjective feelings and pain levels, detailed interpretations can be coded to augment poking and prodding data collected through sensors, giving machine-learning algorithms a fuller picture. With enough input, algorithms will be able to output a series of patterns which physicians can then use in their clinical practice for better diagnoses and understandings of disease.
What has happened in the last eight or so years is that new results coming out of these deep learning methods are allowing us to go after hard data problems that werent accessible before, said Don Brown, the University of Virginias senior associate dean for research, Quantitative Foundation Distinguished Professor in Data Science and a professor in the Department of Engineering Systems and Environment.
Five years ago, Brown was approached by pediatric gastroenterologist Dr. Sana Syed, who was then working as a gastroenterology fellow in her first year on the UVA faculty. Syed was part of a team researching environmental enteropathy, a disease caused by long-term exposure to poor sanitation and hygiene that results in intestinal inflammation and is a major contributor to growth stunting in children living in developing countries around the world.
During her time as a fellow, Syeds role was essentially that of an algorithm. By sifting through thousands of images taken by a video capsule endoscopy a tiny wireless camera that works its way through a patients gut in six to eight hours Syed was tasked with tagging any abnormal images, such as polyps, bleeding and ulcers, to understand tissue structure and function in the context of inflammation. The identification of disease patterns would ideally minimize the need for doctors to conduct endoscopies (the collection of tissue from a patients intestine, which is not a sustainable practice in many low- and middle-income countries) to confirm diagnoses. The tedious task pushed Syed and her colleagues to explore the use of AI as a way of picking up patterns of disease in tissue samples, saving countless hours of analysis.
That is when Syed approached Don Brown in a pursuit to intersect big data and medicine. With such an accomplishment, physicians could begin to more quickly and more accurately predict important inflammatory bowel disease outcomes not only assisting physicians, but also giving patients more peace of mind.
What is going to happen is that a patient shows up, and their data is plugged into these larger algorithms that are trained to learn off patterns that may be representative of you. Then you will be able to predict a specific patients outcome, Syed said. The idea is that you will be able to get more tailored data and have the ability to give specific risk percentages.
In addition to identifying patterns in environmental enteropathy, Syed is researching the effectiveness of AI in other inflammatory bowel diseases, such as Crohns and celiac disease. According to Syed, algorithms that predict scar tissue development in Crohns patients, for example, or individualized risk percentages for thyroid disease and diabetes in celiac patients, would be game-changers in determining more accurate diagnosis and likelihood of disease, allowing clinicians to develop targeted medications and treatments.
That is the thinking we are moving toward: Lets not just try to stop the disease; we want to prevent it and cure it. That is the goal.
To ensure that AI in medicine is effective, Brown said that data scientists and clinical researchers must be aware of inherent biases prevalent in smaller data sets that are many times missed when that data is generalized.
Algorithms work in a way that gets it the highest reward, and if it can get that reward through a biased set of data, it will use it, Brown said. You have to make sure that you are giving [the algorithm] a fair cross section of data so that it can give you results that are truly answering the question that you are after.
For Syed, one of the biggest issues lies in the lack of publicly available data sets. When determining patterns in celiac patients, Syed and her team parsed through 2,000 to 3,000 electronic health records to collect data from the desired population. Instead of recreating the wheel by labeling hundreds of thousands of biopsies, Syed hopes to gather medical information through large industry partners such as Takeda, a R&D-driven global biopharmaceutical company.
A lot of this cross-thinking happens when there is open access to data, but that has to be cleaned and sorted and thoughtfully put out there, Syed said.
Once data is collected and confirmed to be bias-free, the final step is ensuring interpretability. When many clinicians do not have a background in data science, the only way to cross the disciplinary boundary is to ensure that the data is communicated effectively, which is a responsibility that falls back on the data science community.
At the heart of this is making it interpretable to the clinicians so that they get what it is that the system is telling them and how it can be used, and what worth it is, Brown said. And then, they can look at individual patients and decide what makes sense.
Machine learning algorithms are being used across medical disciplines throughout the world of health. Within UVA Grounds, algorithms are being used to predict the effects of cardiac disease treatments, understand health conditions through smart watches in UVAs Link Lab, and analyze real-time diabetes-monitoring data, to name a few. As Syed, Brown and other researchers continue to evolve their AI capabilities, clinicians will begin to transform the ways in which they can accurately predict, determine and treat disease.
The more I have learned about [big data], the more I have understood its potential impact in medicine across all specialties, Syed said.
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