Daily Archives: February 3, 2022

A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58 – Nature.com

Posted: February 3, 2022 at 4:16 pm

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A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58 - Nature.com

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Whole Genome Amplification Market Projected To Develop At A CAGR Of About 7.9% By 2025 | Exclusive Report by Esticast Research – Bristol City…

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Esticast Research has published a new report titledWhole Genome Amplification Market By Type (Complete WGA Kit, Single Cell WGA Kit, WGA & Chip DNA Kit, WGA Reamplification Kit, And Others), By Application (Disease Diagnosis, Drug Discovery & Development, Research, Agriculture & Veterinary, Forensics, And Others), By End-User (Hospitals & Clinics, Pharmaceutical & Biotech Companies, Organizations, Contract Research, Research & Academic Institutes, And Others), And By Region Global Industry Perspective, Comprehensive Analysis, And Forecast, 2019 2025.According to the report, Global Whole Genome Amplification Market Projected To Develop At A CAGR Of About 7.9% By 2025.

The top Leading Market Players Covered in this Report are :Qiagen NV, Sigma-Aldrich, LGC Group, and GE Healthcare.

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Whole Genome Amplification Market Projected To Develop At A CAGR Of About 7.9% By 2025 | Exclusive Report by Esticast Research - Bristol City...

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Replicas: on Rai 2 first tv the sci-fi with Keanu Reeves – D1SoftballNews.com

Posted: at 4:14 pm

S.and after the first evening you are already saturated with the Sanremo Festival, tonight on Rai 2 at 9.30 pm it arrives on first tv Replicasfilm with Keanu Reeves halfway between science fiction, thriller and family melodrama. A rambling film, but enjoyable in its own way (especially for B-Movie lovers), which he certifies as the actor of the trilogy Matrix is now the undisputed king of the sci-fi genre.

Directed, with a heavy hand, by Jeffrey Machmanoff, the film unfortunately it suffers too much from some now obsolete themes. And the good acting performance of the protagonist is not enough to make it exciting too complex a story and excessively layered. Even for the most attentive and patient spectator.

William Foster (Keanu Reeves) is a scientist who deals with cloning and bioengineering. Man has been trying for some time to graft the neural mind of newly dead subjects into robotic bodies but every attempt has always been in vain. But when, due to an accident, the man loses his wife and three children Matt, Sophie and ZoeWilliam decides to experiment on them with new techniques which perhaps will allow him to carry out his experiment.

The scientist thus he transfers their minds to clones but unfortunately the little Zoe is excluded due to the lack of a fourth cloning tank. Now William will have to transfer the brain to the clones and erase all memories of Zoe but will he be able to perform this complicated procedure? AND will the replicas be in all respects like the originals?

For two decades now, the combination of Keanu Reeves and science fiction should, in theory, always be a winner. Just think of the success of the trilogy Matrixof the fictional saga of John Wick and, even earlier, the little cult of 1995 Johnny Mnemonic. It is therefore surprising that the actor got involved in a project that, on paper, seems to have already lost from the start. Replicas in fact it offers immediately an old imaginary, made up of clones and virtual reality which ten years ago had already gone out of fashion.

Not to mention the speech on the so-called transhumanism, or the theory that advocates a total fusion of the human body with technology. Although the theme, albeit dated, lends itself to numerous reflections, the film chooses the way of hard and pure entertainment.

With a turn, about half an hour from the end, which leads to conspiracy thriller, when the shady bosses of the protagonist steal the precious clones from him, but unfortunately the film does not manage to ennoble all the elements put in place.

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Replicas thus becomes a b-movie with a thousand implications left halfway, with bad digital effects and a plot halfway between Frankenstein And The Island. Only the performance of Keanu Reeves is saved, forced to say many stupid things, and frankly incomprehensible if you are not a scientist, but with a deep conviction. AND his method of acting, not at all emphatic, gives complex nuances to a tragic but too monotonous character.

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Replicas: on Rai 2 first tv the sci-fi with Keanu Reeves - D1SoftballNews.com

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Early-Stage Beginning of Psoriasis: Symptoms and Types – Greatist

Posted: at 4:12 pm

Symptoms can start at any age, but the first signs of psoriasis often occur between the ages of 15 and 25, according to the National Psoriasis Foundation.

When psoriasis first appears, you start to notice symptoms of inflammation on your skin. This can include:

As the condition progresses, symptoms can start to worsen or become more noticeable.

Symptoms can vary based on the type of psoriasis (well get to the seven main subtypes in a sec), the amount of psoriasis, and the area thats affected.

While psoriasis can show up anywhere on your body. It most commonly develops on your:

The features, feels, and early symptoms of psoriasis might often depend on what type you have.

Plaque psoriasis is the most common type, affecting 80 to 90 percent of people with the condition.

This form of psoriasis usually first appears as thick, raised patches of skin aka plaques. These plaques can be red, purple, or silver and often vary in size. Over time, they may start to feel dry and scaly, which can cause them to itch like crazy.

Guttate psoriasis appears as tiny bumps that may pop up suddenly on your skin. These bumps, or spots, are usually red or pink and have a scaly texture.

Guttate psoriasis often begins to show up on your arms, legs, or torso, but the condition can develop in other areas.

Guttate spots are known to clear up on their own and sometimes never make a return appearance. No one really knows why this happens, making guttate psoriasis one of the more mysterious psoriasis types.

While other forms of psoriasis are raised and rough to the touch, inverse psoriasis causes flat, raw-looking rashes in folds of the skin. These reddish or purple rashes are usually smooth to the touch, but that doesnt make them any less uncomfortable.

Inverse psoriasis usually develops in areas where skin is constantly rubbing on skin (like the armpits, under boob area, and even the genitals). This can cause increasing levels of soreness or discomfort over time especially when sweat gets trapped in these folds.

When it comes to pustular psoriasis, youll usually see puss-filled bumps often appearing on your hands and feet. These small, inflamed bumps can typically be confused for acne when they first appear.

But youll def be able to tell the difference as the condition progresses. The skin underneath the pus-filled bumps will become red and swollen. The area can also become itchy and sore.

As the bumps dry out, theyre usually replaced with scaly, brown dots.

If you start to experience symptoms of erythrodermic psoriasis, call the doctor STAT.

This rare, severe form of psoriasis can cause large chunks of skin to shed, leading to debilitating pain. It can also cause an elevated heart rate, dehydration, fever, chills, and muscle weakness. Erythrodermic psoriasis can also lead to hypothermia, making it difficult to stay warm.

Erythrodermic psoriasis spreads fast, causing visible inflammation in nearly 90 percent of your body. This condition can resemble a burn at first, with the skin becoming red, dry, and tender to the touch. You may experience intense itching as the rash spreads.

Most cases of erythrodermic psoriasis occur in people who already have another form of psoriasis. Talk with your dermatologist ASAP if you notice your condition becoming worse or not responding to treatment, as this condition can be life threatening.

Nail psoriasis affects well, your nails (obvi). Nail psoriasis is pretty common, impacting about 50 percent of people who already have another type of psoriasis.

At first, you may notice discoloration of your nails (usually yellow, white, or brownish hues), as well as pitting in your nails themselves. As the condition develops, larger dents in the nail may form, and the nail may become rough and crumbly.

Skin cells can also build up underneath your nails, causing the nail to lift and detach from the skin of your finger or toe.

Psoriatic arthritis (PsA) gets under your skin literally. This subtype affects the joints and most often occurs in people who already have psoriasis. It can develop at any age, most commonly appearing between ages 30 and 50.

Early signs of PsA can include swollen or tender joints, swelling on the knee or back of the leg, and pain on or around your heel. You may also notice stiffness, specifically in the mornings (because getting out of a cozy bed isnt hard enough sometimes!).

Its important to seek treatment for PsA. Ignoring the condition might lead to difficulty moving and even physical disability.

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Early-Stage Beginning of Psoriasis: Symptoms and Types - Greatist

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Dimethyl Fumarate’s Effectiveness and Safety in Psoriasis: A Real-Life Experience During the COVID-19 Pandemic – DocWire News

Posted: at 4:12 pm

This article was originally published here

Dermatol Ther (Heidelb). 2022 Feb 1. doi: 10.1007/s13555-022-00684-3. Online ahead of print.

ABSTRACT

INTRODUCTION: Dimethyl fumarate (DMF) is approved as oral systemic treatment for moderate-to-severe psoriasis. Scarce evidence is available for DMF treatment in psoriatic patients at the time of COVID-19 pandemic. The objective of this study was to assess the long-term effectiveness and safety of DMF monotherapy in moderate-to-severe psoriasis during the COVID-19 pandemic period.

METHODS: This multicenter, retrospective study included patients with moderate-to-severe psoriasis who had received a 48-week DMF treatment during the COVID-19 pandemic. Selected outcomes were: variation of mean PASI, proportion of patients achieving PASI50 and PASI75, variation of mean PGA and face PGA, genital PGA, scalp PGA, mean itch VAS and mean DLQI.

RESULTS: Forty-four patients were enrolled, and four patients became COVID-19 positive during the observation period but did not discontinue DMF therapy. DMF produced a significant improvement of signs and symptoms of psoriasis as expressed by mean PASI variation from 13.07 at baseline to 6.11 at week 48 (p < 0.0001), itch VAS from 3.22 at baseline to 1.18 at week 48 (p < 0.001), PGA from 2.84 at baseline to 1.30 at week 48 (p < 0.0001) and DLQI from 13.09 at baseline to 6.07 at week 48 (p < 0.0001). The percentage of patients who achieved PASI50 and PASI75 was 4.55% at week 4 and 59.09% at week 48 and 0% at week 4 and 22.73% at week 48, respectively. A clinical important decrease of mean PGA score was observed in all subgroups, face psoriasis, genital psoriasis and scalp psoriasis. Adverse events were predictable and manageable.

CONCLUSIONS: DMF monotherapy is an effective and safe treatment option in moderate-to-severe psoriasis also in patients who develop SARS-CoV-2 infection.

PMID:35103934 | DOI:10.1007/s13555-022-00684-3

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Dimethyl Fumarate's Effectiveness and Safety in Psoriasis: A Real-Life Experience During the COVID-19 Pandemic - DocWire News

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Plaque Psoriasis Treatment Market 2022 Booming Across the Globe by Share, Growth Size, Key Segments and Forecast to 2027 Construction News Portal -…

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Latest Plaque Psoriasis Treatment Market report added by In4Research provides major industry dynamics such as growth drivers, current and future trends, latest developments, threats, challenges, and opportunities in the global market are deeply analyzed. The competitive landscape of the Global Plaque Psoriasis Treatment Market, along with the profiles of the major companies is presented in the report. Regional Market analysis covers North America, China, Africa, Germany, APAC, and more regions have been analyzed individually for a more granular view of the performance of each region in the Plaque Psoriasis Treatment Market and the varying reasons for its positive and negative growth.

The Plaque Psoriasis Treatment Market Report Covers Major Players:

To Get Sample Copy of Plaque Psoriasis Treatment Market Report with Complete TOC, Figures & Graphs Connect with us at https://www.in4research.com/sample-request/60819

The report on the Plaque Psoriasis Treatment market provides a brief overview of the market along with the product definition and market scope. The sections following the introductory chapter provide an in-depth study of the market based on extensive research analysis. Along with the market dynamics, the report also presents a comprehensive analysis of the market covering the supply and demand forces.

Plaque Psoriasis Treatment Market Segmentation:

The global market for Plaque Psoriasis Treatment is set to find a segmentation in the report that would be based on type and application. These segments have a better acceptance of various factors that can be taken into consideration to understand how the market can chart the future path.

Plaque Psoriasis Treatment Market Breakdown based on Product Type:

Plaque Psoriasis Treatment Market Breakdown based on Application:

Plaque Psoriasis Treatment Consumption Breakdown Data by Region

For more Customization, Connect with us at https://www.in4research.com/customization/60819

Key Topics Covered in Plaque Psoriasis Treatment Research Study are:

5.1 Introduction

5.2 Market Dynamics

5.3 COVID-19 Pandemic-Driven Market Dynamics and Factor Analysis

6.1 Introduction

6.2 Value Chain Analysis

6.3 Porters Five Forces Analysis

6.4 Pricing Analysis

And more

9 Plaque Psoriasis Treatment Market, By Region

10.1 Overview

10.2 Market Evaluation Framework

10.3 Estimated Market Share Range of Key Players

11.1 Overview

11.2 Competitive Leadership Mapping

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Plaque Psoriasis Treatment Market 2022 Booming Across the Globe by Share, Growth Size, Key Segments and Forecast to 2027 Construction News Portal -...

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CTMA Expands Its Digital Clinical Trial Solution to a Second Therapeutic Area Rheumatology – Business Wire

Posted: at 4:12 pm

PARIS--(BUSINESS WIRE)--CTMA, a clinical research service company that is working to change the way patients are detected for clinical trials, announced that it is expanding its CT-SCOUT technology offering into a second therapeutic area rheumatology. CT-SCOUT, the companys multi-device platform that allows health care professionals (HCP) to identify trial candidates, will now be available for sites, sponsors and contract research organizations (CROs) in three rheumatological indications: Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism.

Pierre Pellier, Chief Executive Officer of CTMA, said: We are thrilled to expand our platform by adding a new therapeutic area. This enables us to support a larger pool of patients, studies, sites and sponsors. Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism, are chronic, debilitating diseases that affect a large population of patients for whom clinical trials may represent an important therapeutic alternative solution.

Building on its successful experience in inflammatory bowel disease (IBD), CTMA plans to continue expanding its offering to include additional therapeutic areas in order to accelerate clinical research. Currently, a majority of clinical trials are delayed and up to 10% of trials are never completed. CTMAs technology allows healthcare providers to use an app in real-time alongside a patient, to efficiently identify trials running at the site that will match the patients profile.

Patients suffering from Rheumatoid Arthritis, Ankylosing Spondylarthritis and Psoriatic Rheumatism are still looking for new therapies as there is a large unmet medical need. Ultimately, the goal of CTMAs app-based technology is to help bring innovative therapies to patients faster.

Dr. Emmanuelle Dernis-Labous, a rheumatology expert at the Hospital Center of Le Mans, said: Developing a recruitment algorithm for clinical trials focused on three major rheumatology indications has been a fascinating exercise. This will contribute to making clinical trials more visible and more accessible to patients suffering from these chronic diseases, who are in need of alternative therapeutic options.

About CTMA:

CTMA is a clinical research service company that is working to change the way patients are detected for clinical trials. Based in Paris, the company has developed an innovative solution to address the critical patient detection problem that affects most clinical trials. In 2014, CTMA launched its innovative, patented methodology and application, to increase recruitment in clinical studies. Since then, CTMA has successfully worked with the larger sponsors in inflammatory bowel disease (IBD) ulcerative colitis (UC) and Crohns disease (CD), where it demonstrated that sites equipped with its solution can recruit by up to four times more than non-equipped sites1.

More than 250 investigational sites have benefited from this unique solution so far. For more information, please visit: http://www.ctma.fr.

_________________1Ref: Bouhnik Y, et al. Gastroenterology 2020- https://www.gastrojournal.org/article/S0016-5085(20)30371-1/pdf

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Chilly Las Vegas to warm up a bit Thursday, forecasters say – Las Vegas Review-Journal

Posted: at 4:10 pm

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STUDY: Half of Las Vegas workers have high risk of automation – KLAS – 8 News Now

Posted: at 4:10 pm

LAS VEGAS (KLAS) A recent study predicts thousands of local jobs could vanish to automation and it says Las Vegas has the nations highest percentage of workers at high risk of being replaced by technology.

The hospitality industry is already embracing technology such as the kiosks at restaurants, robots serving food, automated check-in procedures at hotels and more.

The study by Commodity.com says more than 49% of Las Vegas workers are at a high risk of automation, while 42% of all U.S. workers face the same risk. The study says gaming dealers have a probability of automation of 96%.

While the idea of automation isnt new, the pandemic has accelerated a lot of technology in the workforce.

Irene Bustamante Adams, the deputy director and chief strategy officer for Workforce Connections offers this advice.

We know that automation is coming, its here, its even going to get more accelerated over the next couple of years. So if youre a job seeker, the concern should be what kind of skills do I need to learn? How do I take what I know now and upscale?'

Automation is more likely to impact lower-skilled jobs that involve repetition. Even so, it doesnt sit well with some jobseekers.

I think its absolutely a crime because. Its just putting a lot of us who would like to work out of jobs. Also, you want us to do it and then the machines dont work, said Lynn Beamer, who is looking for a job.

Researchers behind the study looked at the latest data from the U.S. Bureau of Labor Statistics and the University of Oxford.

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Heres how NHL All-Star Weekend came to fruition in Las Vegas – Las Vegas Review-Journal

Posted: at 4:10 pm

NHL All-Star Weekend in Las Vegas owes a debt to the Golden Knights trip to the 2018 Stanley Cup Final.

The leagues creative team knew it had to be bold, audacious and daring to stand out during a tremendous sports weekend in one of the entertainment capitals of the world. So the group, led by NHL chief content officer Steve Mayer, flashed back to something it had pulled off June 7, 2018, before the Knights lost to the Washington Capitals in the decisive Game 5 of the finals.

The pregame entertainment before puck drop featured lights, instruments and the Las Vegas band Panic! at the Disco singing their song High Hopes. It all just happened to be on a floating stage in the middle of the Bellagio fountains.

We as event producers do this all the time, Mayer said. You hope nothing goes wrong, but you really hope you can do something that youll remember for a lifetime. That was one of those events like Wow, that was so cool.

That inspiration pushed the team to create events as memorable as possible for the skills competition Friday and the All-Star Game on Saturday at T-Mobile Arena. Pucks are going to fly into the fountain and a giant deck of cards is going to hang from Las Vegas Boulevard.

The NHL knows the bar for a memorable event in Las Vegas is high, and the league has put a lot of effort in attempting to clear it.

How do you do something in this town that actually gets people to talk a little bit? Mayer asked. And when you leave town, gets them to remember what you did? Thats not easy to do. And I hope that we accomplish that.

Long time coming

Knights owner Bill Foley said 100 percent he always wanted to have an All-Star Game in Las Vegas. Team president Kerry Bubolz said the club first had conversations about hosting All-Star Weekend in its inaugural season of 2017-18.

The Knights knew they werent likely to host anytime soon. But they did want the possibility on the NHLs radar. The league went to Tampa, Florida, in 2018, San Jose, California, in 2019 and St. Louis in 2020 before skipping the event during its pandemic-shortened 2021 season.

The two sides decided Las Vegas would be the place to bring it back in 2022. The unique aspect of it was the Knights didnt have to do much selling to make it happen.

After last year, we were just monitoring, what are we going to do, where can we go? Mayer said. It just made all the sense in the world that this would be a choice.

Bubolz spent 13 years with the Cleveland Cavaliers before coming to Las Vegas in 2016. His final three years involved trying to get the NBA All-Star Game to Cleveland, a bidding process that required things such as having a hotel with 600 rooms close to the venue. The city is finally hosting this year.

Those questions arent an issue in Las Vegas. There are more than enough hotel rooms to accommodate everyone. There is also plenty of nearby space for secondary events such as the NHLs Fan Fair, which started Thursday and ends Sunday at the Las Vegas Convention Center West Hall.

Normally those are bigger parts of the process, Bubolz said. That part of the conversation, we didnt spend a lot of time (on it). Its more, Were thinking Vegas, were thinking this time, are you guys ready to go? And, of course, we said yes.

Prep time

The Knights needed T-Mobile Arena for Tuesdays game against the Buffalo Sabres, but Mayer and his team arrived late last week to begin preparations.

There are always a huge number of moving parts for an event of this size. Fifty to 60 cameras need to be set up for the NHLs two national TV partners ESPN (U.S.) and Sportsnet (Canada). Lights and pyrotechnics need to be brought in. Sound equipment for the musical acts Zedd during the pregame introductions for the All-Star Game and Machine Gun Kelly during the second intermission must be tested.

Besides putting everything in place, Mayer and his team need to rehearse, rehearse, rehearse. In parking lots. Outside T-Mobile Arena. Inside the building. Everything needs to be rehearsed so the first time its happening doesnt take place in front of a live audience.

Mayer and his team will even practice the check presentation to the winning team of the All-Star Game. Stand-ins will go through many of the skills events because the NHL schedule went through Wednesday.

These events dont just magically at the snap of a finger happen, Mayer said. Weve got the best team in the world at producing events. And we roll with the punches.

Given the Knights reputation for in-arena presentation they have already projected a giant squid and a flying jet onto the ice this season anticipation is high.

Our city is pretty electric, said Knights captain Mark Stone, who is appearing in his first All-Star Weekend. Our building is the best in the NHL at atmosphere and production. Im excited to see what they put together for the All-Star Game. Im sure our fans will appreciate it.

High bar

Mayer knows hes competing with star performers on the Strip for entertainment dollars during All-Star Weekend.

Theres also the matter of hosting a sporting event the same week that the East-West Shrine Bowl (Thursday) and the NFLs Pro Bowl (Sunday) take place at Allegiant Stadium. Its going to be hard to stand out.

Luckily for him, the surroundings and local team sparked the NHLs creativity. Mayer said the theme of the event will be old Vegas to new Vegas using the Knights as a transition. He is going to take advantage of the location to create experiences worthy of the reputation the team has earned as one of the greatest shows on ice.

Our event and our game presentation, we tried to make it Vegas five years ago, Bubolz said. Make it unique and different. We had a lot of intention about that. The league loves that. They want to bring that to life in the All-Star festivities.

Panic! at the Discos performance led to the creation of the NHL Fountain Face-Off for Fridays skills competition during which eight players will travel by boat to a rink at the Bellagio fountains. They will try to shoot pucks into five targets in the least amount of time while water and wind try to throw them off.

The league also created the NHL 21 in 22 event in which five players shoot at an oversized deck of cards on Las Vegas Boulevard and try to create a hand of 21 without going bust.

The goal was to create events that could only happen in Las Vegas, would get players excited to participate and would be talked about for years.

The one thing about Vegas is theyve never been shy about exposing those unique opportunities and showing what were all about, said Knights coach Pete DeBoer, who will lead the Pacific Division in the All-Star Game. I think guys will enjoy it. I know guys are looking forward to coming into town.

The future

Las Vegas hosting NHL All-Star Weekend further cements the ties between the league and the city.

The NHLs awards show was a fixture in town before the COVID-19 pandemic. The Knights 2017 expansion draft took place at T-Mobile Arena. The team took part in an outdoor game in Stateline at Lake Tahoe last season.

Its fair to wonder whats next. Foley said he hopes the event will lead to another outdoor game or a draft.

Mayer said Las Vegas would be a great place for a draft, but a location for an outdoor game would have to be worked out. Plus, he added, the NHL wants to share some of that love around the league.

Still, theres no question All-Star Weekend has a chance to further what has been a surprising yet undeniably effective partnership between the league and Las Vegas. Hockey in the desert. Turns out it works.

Were extremely fortunate in only our fifth season to have the opportunity, Bubolz said. Its a great, tremendous showcase not only of the best players in the world in our game, but its a tremendous showcase of the city of Las Vegas and the surrounding valley.

Contact Ben Gotz at bgotz@reviewjournal.com. Follow @BenSGotz on Twitter.

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Heres how NHL All-Star Weekend came to fruition in Las Vegas - Las Vegas Review-Journal

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