Daily Archives: January 21, 2022

The Institute for Drug Development and an archive of institutional histories – The Cancer Letter

Posted: January 21, 2022 at 11:24 pm

The Cancer History Project archives the histories of each of its contributing institutions, whether through profiles of institutions, interactive timeline, photo galleries, and more.

The following are histories submitted by Cancer History Project contributors Mays Cancer Center at UT Health San Antonio, Memorial Sloan Kettering Cancer Center, Fox Chase Cancer Center, Seattle Cancer Care Alliance, Rutgers Cancer Institute, Roswell Park Comprehensive Cancer Center, City of Hope, and MUSC Hollings Cancer Center.

The Institute for Drug Development (IDD) was founded in 1991 as the research arm of what was then called the Cancer Therapy & Research Center (CTRC), in San Antonio.

The IDD has been at the forefront of developing new cancer drugs for decades, with approximately 20 drugs approved by the U.S. Food and Drug Administration for cancer treatment. The program offers patients the opportunity to receive drugs that are only available here and that might not become available to cancer patients elsewhere for several years.

There is no profit in curing the body if, in the process, we destroy the soul.

When President Richard Nixon signed the National Cancer Act 50 years ago, the goal was nothing short of eradicating cancer. By launching the nations War on Cancer, the act dramatically increased funding for research. Importantly, Memorial Sloan Kettering Cancer Center (MSK) was named one of the three original comprehensive cancer centers in the country.

For more than 137 years, MSK has made historic contributions driving discovery and improving patient care. MSK has a deep history of cancer research that has continually advanced the field and provided new and powerful ways for the institutionand the wider cancer communityto diagnose and treat cancer. Driving the effort is one of the worlds most dynamic programs of cancer research, with more than 100 research laboratories focused on better understanding the many types of cancer and the biology underlying them.

Fox Chase Cancer Centers Talbot Research Library is named in memory of Timothy R. Talbot, Jr. but his true legacy is the entire cancer center. In fact, the notion of a comprehensive cancer center was Talbots innovation.

In 1957 Talbot succeeded Stanley P. Reimann as director of the Institute for Cancer Research. He guided the Institute for the next 20 years, culminating in the merger with the American Oncologic Hospital that created Fox Chase Cancer Center. He then became the new cancer centers first leader.

January 2011 Ten years. Thousands of lives saved. Seattle Cancer Care Alliance is using this tagline to help celebrate its official 10th anniversary. It was in January 2001 that SCCA the patient care arm of Fred Hutchinson Cancer Research Center, UW Medicine and Seattle Childrens opened its new outpatient building and headquarters on Lake Union. The result today is the Pacific Northwests only federally designated comprehensive cancer center.

During the past decade the number of patients seen annually at SCCA grew by almost 40% to 25,211 in 2010, annual revenue increased sevenfold to $282.3 million last year and the number of employees more than doubled to 973. Through its network of community hospital affiliations, certain SCCA services for patients and staff are now available in 10 locations in Washington, Alaska and Montana.

Rutgers Cancer Institute of New Jersey, first called The Cancer Institute of New Jersey, was born in 1993 as the result of a P20 planning grant that was awarded in 1992.

Just four years after opening, the institute achieved the National Cancer Institute (NCI) cancer center designation, a program that was created as part of the National Cancer Act of 1971 to recognize cancer centers that meet rigorous standards for state-of-the-art research focused on developing new and better approaches to preventing, diagnosing, and treating cancer.

In 2002, the institute was elevated to comprehensive status, the highest and most prestigious designation from the NCI held by only a few dozen such centers across the nation.

In 1913, tuberculosis would kill nearly 150,000 people, more than twice the toll taken by cancer. A group of committed volunteers refused to accept this tragedy and established the Jewish Consumptive Relief Association (JCRA), a free, nonsectarian tuberculosis sanatorium.

After hosting several fundraisers, the JCRA placed a down payment on 10 acres of sun-soaked land in Duarte, California, where they would establish the Los Angeles Sanatorium a year later. The original sanatorium consisted of two canvas cottages and ultimately launched a century-long journey that would place City of Hope at the forefront of the nations leading medical and research institutions.

In 2009, the Hollings Cancer Center (HCC) attained National Cancer Institute (NCI) designation, a distinction held by only 63 other cancer centers in the United States, and the only such institution in the state.

During a dignitary-packed ceremony on March 2, MUSC President Raymond Greenberg, M.D., Ph.D., called it one of the most important achievements in MUSCs history. Becoming an NCI cancer center is very difficult, Greenberg said. Its a very competitive peer review process.

This column features the latest posts to the Cancer History Project by our growing list of contributors.

The Cancer History Project is a free, web-based, collaborative resource intended to mark the 50th anniversary of the National Cancer Act and designed to continue in perpetuity. The objective is to assemble a robust collection of historical documents and make them freely available.

Access to the Cancer History Project is open to the public at CancerHistoryProject.com. You can also follow us on Twitter at @CancerHistProj.

Is your institution a contributor to the Cancer History Project? Eligible institutions include cancer centers, advocacy groups, professional societies, pharmaceutical companies, and key organizations in oncology.

To apply to become a contributor, please contact admin@cancerhistoryproject.com.

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The Institute for Drug Development and an archive of institutional histories - The Cancer Letter

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The prospects of another American (un)civil war – Al Jazeera English

Posted: at 11:24 pm

There are probably nicer ways to say it, but when I read that in a 2021 national poll, 46 percent of Americans believed that another civil war is likely compared with 43 percent who did not, the only words that came to mind were mutually assured destruction MAD.

Watching from the war-torn Middle East as America forecasts doom and gloom makes me wonder if the country has gone off the rails.

I mean seriously, America, what are you thinking? Instead of acting fast to prevent such a calamity, you continue to fan the fire, recklessly moving towards civil strife, eyes wide open.

If you have forgotten the horrors of your own devastating civil war, take a look at our ongoing bloody and disastrous civil wars, which have collapsed states under the yoke of violent polarisation.

Thing is, you never had it so good in terms of prosperity, freedom, and wellbeing, so why throw all of it away over differences of opinion? Why not manage your disagreements democratically? In other words, why not put democracy back at the centre of your domestic policy, instead of pretending to put it at the centre of foreign policy?

As my all-time favourite American satirist, the late George Carlin put it, civil war is an oxymoron. Indeed, not only war is not civil, but what we call civil war is the worst kind of war because of the way it tears apart the national fabric.

Yet, more than 150 years after the American civil war ended in victory for the federal union and the abolition of slavery, more than a few nitwit hillbillies are itching for another fight.

Now that is not to say that all those responding in the affirmative in the 2021 opinion poll want a civil war, many are certainly worried, even fearful of such a scenario.

But as Carlin often reminded us, America is a warlike nation and when there are no brown people to bomb somewhere else, it turns inward, applying war to anything it hates. So, there is the American war on poverty, the war on drugs, the war on crime, and of course, the war on cancer, the war on AIDS, and of late, the war on COVID-19.

Now that Americans are split, polarised into two extremes feeding into each other, there is an intensifying war on fascism and an ugly war on liberalism.

These cultural and ideological wars are fuelled by racism and inequality and are sure to have bloody manifestations in the form of violent nationwide demonstrations, attacks on public property, bombings of clinics that provide abortions, etc all of which the country has already experienced in the past. Some even reckon armed militias may appear and engage in mass violence.

All of this begs the question: What role does the media play in all of this? Is it radicalising society and polity through its hyperbolic journalism by opinion, deepening the rights obsession with liberal tyranny and the lefts obsession with fascism writ large?

Suffering from Trump withdrawal symptoms, corporate media is clearly complicit as it compensates for the loss of its golden goose by pushing sensational, even apocalyptic coverage of the divided country he left behind. The same goes for social media platforms which continue to fuel division.

At any rate, the high degree of polarisation, beliefs in alternative realities, and celebration of violence in American society suggest we are at the brink of conflict, in the words of one Yale University historian.

According to this scenario, Donald Trump is the perfect catalyst for the cataclysmic dangers facing America, including its outright dissolution, as masses of people move towards friendlier regions of the country to escape intimidation and violence.

Trumps main rivals for the party nomination to the 2024 presidential elections are his former minions, Governor Ron DeSantis of Florida and ex-secretary of state, Mike Pompeo, who do not pose a serious challenge.

The former presidents sinister populism and solid popularity on the right, coupled with his powerful grip over the Republican party, make him the likely candidate to preside over and escalate the next national crisis come 2024. Trump seems determined to recapture the White House by hook or by crook, and to rule as an authoritarian leader, Vladimir Putin style.

Midterm congressional elections in November 2022 will prove an important stepping stone for Trump, as the candidates he supports may wellwinprimaries against the 10 Republican detractors, who voted to impeach him.

If Biden fails to pass major bills through Congress this year, especially his voting rights agenda, this would weaken his presidency and diminish his popularity even further. Meanwhile, Trumps supporters in some 18 state legislatures have already changed the rules to gain more control over voting and the outcome of the next elections.

If Republicans win a majority in Congress in November, which seemslikely at this stage, Biden will become a sitting duck president, further clearing Trumps path to the White House.

One cannot overstate the dangerofa Trump candidacy, let alone a vengeful second presidency, asIdiscussedin October. He hascaptured the imaginationof the American white right,stripped the Republican elites of allpretence of decency, and turned the GOP into an authoritarian party, all the while radically polarising the country.

An astounding 80 percent of Republican voters say they believe Trumps big lie about the rigged 2020 elections.

If Trump & co escape accountability for the January 6 attack on Congress and for their violent attempts at undermining the democratic process, they are likely to feel invincible and empowered to exploit the current tensions and the increased state of insecurity across the country to sow chaos if they lose the vote once again.

Nothing captures the meaning of a Trump second coming for America and its ramifications the rest of the world, better than the verse of the late Irish poet William Butler Yeats from his poem The Second Coming:

Turning and turning in the widening gyreThe falcon cannot hear the falconer;Things fall apart; the centre cannot hold;Mere anarchy is loosed upon the world,The blood-dimmed tide is loosed, and everywhereThe ceremony of innocence is drowned;The best lack all conviction, while the worstAre full of passionate intensity.

But then again, nothing is inevitable and all is still preventable. The challenge for America is to wake up to the creeping danger and prevent the brewing cultural and ideological fight from devolving into an all-out uncivil war come the 2024 elections.

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The prospects of another American (un)civil war - Al Jazeera English

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The Best Things To Do in Dallas This Weekend (And Next Week!) Elton John Is Coming to Town – PaperCity Magazine

Posted: at 11:24 pm

From an iconic English singers farewell tour to musicals and comedy shows, these are the best things to do in Dallas this weekend (and early next week).

Extend your weekend until Tuesday night with Elton Johns performance at American Airlines Center. On his Farewell Yellow Brick Road tour, John will perform two shows in Dallas: January 25 and 26 at 8 pm. The show was originally scheduled for June 2020, but the English icon will finally be coming to town next week. As the shows title suggests, this will be the singers final tour, so get your tickets now.

Head to Irvings Toyota Music Factory this Friday night to catch indie rock band The War On Drugs. Founded in Philadelphia in 2005, the band is known for hits like Holding On and Under the Pressure. The group now consists of Adam Granduciel, David Hartley, Robbie Bennett, Charlie Hall, Jon Natchez, Anthony LaMarca, and Eliza Hardy Jones. Tickets are available here.

Beginning this week and going through January 30, Tony Award-winning musical Hadestown will be performing at Winspear Opera House. The 2020 Grammy Award-winner for Best Musical Theater Album tells the story of two intertwined mythic tales. One of Orpheus and Eurydice, and the other of King Hades and his wife Persephone. Dont miss the 2019 Best Musical from singer-songwriter Anas Mitchell and director Rachel Chavkin while its in town. Get your tickets here.

Comedian and actor Heather McMahan is heading to Dallas Majestic Theatre this weekend on her Farewell Tour. Recently seen in the new Netflix film Love Hard, McMahan will be performing on Thursday, Friday, and Saturday night. The stand-up comedian also co-created the upcoming Peacock show, Good Grief, currently in development. Tickets are available for her stint at the Majestic here.

Remember Fluffy? The stand-up comedian is back on tour at American Airlines Center this Saturday at 8 pm. Most recently, Iglesias specialOne Show Fits Alldebuted on Netflix in 2019. Before that, he had five other specials on Comedy Central and more platforms. His first TV special,Hot and Fluffycame out in 2007. Tickets are available here.

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Hubble telescope spots a black hole fostering baby stars in a dwarf galaxy – Space.com

Posted: at 11:23 pm

Black holes can not only rip stars apart, but they can also trigger star formation, as scientists have now seen in a nearby dwarf galaxy.

At the centers of most, if not all, large galaxies are supermassive black holes with masses that are millions to billions of times that of Earth's sun. For instance, at the heart of our Milky Way galaxy lies Sagittarius A*, which is about 4.5 million solar masses in size.

Astronomers have previously seen giant black holes shred apart stars. However, researchers have also detected supermassive black holes generating powerful outflows that can feed the dense clouds from which stars are born.

Video: Dwarf galaxys black hole triggers star formationRelated: The strangest black holes in the universe

Black hole-driven star formation was previously seen in large galaxies, but the evidence for such activity in dwarf galaxies was scarce. Dwarf galaxies are roughly analogous to what newborn galaxies may have looked like soon after the dawn of the universe, so investigating how supermassive black holes in dwarf galaxies can spark the birth of stars may in turn offer "a glimpse of how young galaxies in the early universe formed a portion of their stars," study lead author Zachary Schutte, an astrophysicist at Montana State University in Bozeman, told Space.com.

In a new study, the scientists investigated the dwarf galaxy Henize 2-10, located about 34 million light-years from Earth in the southern constellation Pyxis. Recent estimates suggest the dwarf galaxy has a mass about 10 billion times that of the sun. (In contrast, the Milky Way has a mass of about 1.5 trillion solar masses.)

A decade ago, study senior author Amy Reines at Montana State University discovered radio and X-ray emissions from Henize 2-10 that suggested the dwarf galaxy's core hosted a black hole about 3 million solar masses in size. However, other astronomers suggested this radiation may instead have come from the remnant of a star explosion known as a supernova.

In the new study, the researchers focused on a tendril of gas from the heart of Henize 2-10 about 490 light-years long, in which electrically charged ionized gas is flowing as fast as 1.1 million mph (1.8 million kph). This outflow was connected like an umbilical cord to a bright stellar nursery about 230 light-years from Henize 2-10's core.

This outflow slammed into the dense gas of the stellar nursery like a garden hose spewing onto a pile of dirt, leading water to spread outward. The researchers found newborn star clusters about 4 million years old and upwards of 100,000 times the mass of the sun dotted the path of the outflow's spread, Schutte said.

With the help of high-resolution images from the Hubble Space Telescope, the scientists detected a corkscrew-like pattern in the speed of the gas in the outflow. Their computer models suggested this was likely due to the precessing, or wobbling, of a black hole. Since a supernova remnant would not cause such a pattern, this suggests that Henize 2-10's core does indeed host a black hole.

"Before our work, supermassive black hole-enhanced star formation had only been seen in much larger galaxies," Schutte said.

In the future, the researchers would like to investigate more dwarf galaxies with similar black hole-triggered star formation. However, this is difficult for many reasons "systems like Henize 2-10 are not common; obtaining high quality observations is difficult; and so on," Schutte said. However, when the James Webb Space Telescope hopefully comes online in the near future, "we will have new tools to search for these systems," he noted.

Schutte and Reines detailed their findings in the Jan. 19 issue of the journal Nature.

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Hubble telescope spots a black hole fostering baby stars in a dwarf galaxy - Space.com

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What we learn of the universe leads us to God – The Catholic Register

Posted: at 11:22 pm

The universe is beautiful and weve got pictures to prove it. Come May, when the James Webb Space Telescope starts downloading deep space photos, were going to have even more pictures, and astrophysicist and cosmologist Fr. Adam Hinks just knows those pictures will be beautiful too.

Were going to get beautiful pictures from the JWST (James Webb Space Telescope) and thats super-important, Hinks told The Catholic Register. The public loves it, just because theyre beautiful pictures and they make you think about the universe. If youre a person of faith, it helps you think about God too. This is His handiwork.

This onslaught of abstract, pure beauty we see in images of galaxies, nebulas and stars is not just incidental to the science of astronomy, said the Jesuit who holds the Sutton Family Chair in Science, Christianity and Cultures at the David A. Dunlap Department of Astronomy and Astrophysics in the University of Toronto, teaches in the Christianity and Culture program at the University of St. Michaels College and in his spare time is an adjunct scholar with the Vatican Observatory.

Its not secondary. Its not irrelevant, these beautiful pictures, Hinks said. As scientists, we love them too. We certainly study them carefully. We analyze them mathematically. We try to figure out the physics. But at the same time we also love just the images. Theres further beauty when you understand the science.

For Hinks, an encounter with beauty on this scale is also an encounter with God.

When youre in a relationship with someone, when you love someone, youre interested in what that person does. This is what God has done, he said.

As a cosmologist, Hinks studies how the universe came to be what it is. Its a sort of scientific take on history, starting with the Big Bang. Hinks specialty is the very early history of the first instance of the universe, when it was fairly uniform and mostly gas.

The James Webb telescope, with its giant, golden eye that can read infrared light, is going to have the ability to peer back in time to when stars first began to form. The light that hits the James Webb will have travelled for billions of years so long that the wavelengths have stretched out and are no longer visible to ordinary telescopes on Earth, or even the Hubble Telescope that orbits high above the interference of our atmosphere.

The James Webb is about 100 times more powerful than the Hubble. The light it sees dates from about 100 million years after the Big Bang a blink of an eye in the 13.8-billion-year history of the universe. The telescope cost $9 billion (U.S.) and will take almost four months to set up and focus from NASAs Goddard space flight centre in Greenbelt, Maryland.

For now, Hinks isnt part of any of the teams of scientists who have scheduled time on the telescope to run experiments. One of his Jesuit colleagues at the Vatican Observatory is awaiting data from the JWST that will show star populations as the first galaxies formed.

Science is a team sport and even if Hinks isnt booking time on the James Webb, what the eye in the sky sees matters to the cosmologist.

I will certainly have colleagues who are involved in projects on the James Webb telescope. It will certainly impact my research, even if I dont directly work on it, he said.

Its all about filling in the blanks on the long chronicle of the universe, said Hinks.

Theres kind of some fuzzy chapters, he said. We dont have the words on the page yet.

Encountering God in cosmology is no surprise.

Its part of the Christian world view to see the universe as making sense, as something you can study, said Hinks. Christians want to know where it all came from. Those are questions that very naturally lead to scientific curiosity.

Certainly, not every scientist is Christian. But as a Christian, Hinks knows that what he learns leads him back to God.

Our faith tells us something about the origin of the universe that it comes from God, he said. What our faith doesnt tell us is, scientifically, how that works. For the science we need to go out with our telescopes and figure out the equations and all of that.

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