Daily Archives: December 10, 2021

WesCeleb Caroline Pitton ’22: The Short One with Bangs Who Works in Admissions – Wesleyan Argus

Posted: December 10, 2021 at 7:19 pm

c/o Caroline Pitton

One of the best known faces to students even before they enroll at the University, Caroline Pittons 22 smiling face framed by her famous bangs is plastered on the wall of the admissions office, where she can frequently be found when she is not working in a research lab, TAing, or singing. The Argus caught up with Pitton to talk about her time on campus and her future beyond it.

The Argus: Why do you think you were nominated to be a WesCeleb?

Caroline Pitton: I was genuinely so surprised when you told me cause I dont think I know enough people to be a WesCeleb. I feel like I just walk around and recognize most people that pass me, but I think I have a very public-facing job. I work as a senior interviewer in the Office of Admission, and Ive worked in admissions since literally the first week of my freshman year. I used to plan WesFest and Open House, and now I talk to prospective students a lot. That job is the most fun place to work on campus. Everyone who works there is so outgoing and friendly. I also TA a lot so if you took intro bio or intro chem or some French classes, chances are youve seen me as your TA.

A: What are your majors?

CP: Im a biology and French double major with an informatics and modeling minor. I came into Wesleyan knowing I wanted to do biology, and then my pre-major advisor was a French professor and that was a happy accident. Then, I did my minor almost completely by accident. One day [I] was talking to another bio major and figured out that Id done five of the six credits for [the modeling] minor.

A: Did you speak French prior to coming to Wes?

CP: My moms entire extended family lives in France. They do not speak English whatsoever, so she spoke to me in French when I was a baby, and that kind of tapered off, especially when my brother was born and life got wild. I went to a French and English school and all of the kids who went there only spoke French, so I really had to learn how to speak, to communicate with my classmates. I wasnt super invested in the study of French language and culture until I got a couple years into college and I realized how fun it is to speak another language and think about cultures that arent those that youve grown up in.

A: How did you know you wanted to be a bio major?

CP: I was really supported in my science classes in middle and high school. I thought I might want to be a math major at some point but I took intro bio as a freshman in my first semester. I went in and I was like, I think I wanna be a bio major, but if I hate intro bio, its okay to change my mind. I loved it, but I think its not a given that biology majors like intro bio [because] our intro bio curriculum is challenging and fast-paced and intense. Every bio class Ive taken since then Ive liked even more. Its my favorite academic discipline in the world. I could talk your ear off about biology. Thats what I want to do academically and career-wise in the future. Biology is what I want to think about every day.

A: Have you had a favorite class or professor at Wesleyan?

CP: My favorite professor at this university is Professor Joe Coolon in the Biology department. Hes my research advisor. Ive been in his lab since I was a sophomore and we study genomics in fruit flies and yeast. He is one of the best teachers and academic mentors I could ever ask to have. Every time I talk to him, he makes me so excited about science. He has this really infectious energy. He always wants to know whats going on, with my work but also with my life and with my future plans. And he creates a really fun lab environment where everyone works together really well and is genuinely friends in and outside of the work environment.

A: What are you researching?

CP: I spent my whole junior year and the summer after my junior year researching a system in fruit flies that we can use to turn on and off the expression of specific genes, which is very niche. But I looked at this one system and I did a lot of bioinformatics analysis and then I finished that project over the summer, and now Im working on a few other projects. They all have to do with what happens when we expose fruit flies to different environmental toxins, like pesticides, and what happens in the fruit fly genome. Like, which genes get turned on? Do some genes turn on more than other genes? Do they turn off? How do those genes interact?

A: What else are you involved with on campus?

CP: Up until this semester, I sang with Onomatopoeia, the acapella group. I had to take a step back from that this semester, but that was one of the most formative and most fun parts of my college experience. I also music directed two shows for Second Stage my freshman and sophomore years. The friends that I made doing theater and acapella, I still hold so closely.

A: You mentioned that you started working in admissions the first week of [your first] year. How did that happen?

CP: I walked on campus and I was like, okay, I need to find a work-study job. And they have a job fair with a table for admissions. I was like, that seems like a fun place to work. As a [first year], its one of the only offices at Wesleyan that you are aware exists because its the office that you interact with before you are a student. I literally just filled out an application for a random job, which happened to be the intern job, which is event planning mostly. I met a lot of really cool people through it, and working in the Office of Admission gives you a really nice support network of other students, but also the professional adult staff that work there. Going to work three times a week and seeing the same people and having office chit-chat and building those relationships that still exist three years later was really stabilizing.

A: What are your plans after graduation?

CP: Im going to be a research associate in a lab at the Dana Farber Cancer Institute in Boston. Im working in a lab that studies the genetics and genomics of blood cancers. Im also really lucky that I found a job this early. Its a lot of biology concepts that I learn about and I practice in my undergraduate lab and classes, but its applied to medicine and to people in a way that we dont do at Wesleyan, which is really exciting to me as someone that wants to work more in medical research and human genetics in the future.

A: How do you think your friends would describe you?

CP: They make fun of me for how much I talk about flies, but also people know me as having bangs. So when we have conversations about how my housemates describe each other to people that dont know us, I am the short one with bangs who works in admissions.

A: Did you ever not have bangs?

CP: I have quite literally never not had bangs. At my first haircut where I had a substantial amount of hair, my mom said, I think bangs would be cute. And I was two years old, and now Im 21 and I still have bangs. I considered growing them out during COVID-19, but then I had an identity crisis. And I was like, Im gonna come back for my junior year in a mask and Im not gonna have bangs. No one will recognize me; the bangs have to stay.

A: Do you have a favorite Wesleyan story?

CP: One that really stuck with me, especially during COVID-19, was in February of 2020. Ono and Slender James threw a kegcert, which is a concert with a keg in a Fauver. It was the weekend before spring break and it was probably the most fun concert that wed ever done in anyones memory of people that were in Ono at the time. The singing, I think, was good, but it was more like, the energy was really exciting and it was a packed Fauver. All of our friends were there and were screaming and people were dancing. I remember finishing that concert and everyone in Ono was like, That was so fun. We have to do that again. Then obviously we all went home and [didnt come] back. I think for a long time, especially last year when no one was socializing, that was something that I really held onto as being like the last real party that I had been to. And it was such funthere was nothing bad about that night.

A: What are you most proud of in your time at Wes?

CP: Im really proud of how I pushed myself out of my comfort zone to try new things during my time at Wesleyan. I didnt become complacent. I mentioned doing student theater. I had never done theater before college. That was totally out of my comfort zone, and Im so glad I did it. I had so much fun and I learned a lot. Same with research. I didnt think I wanted to do research and then I tried it, and now its literally what Im doing for a job next year. And same with the French major. I had never thought of myself as a humanities person, and now I read French literature.Im proud that I didnt box myself into only doing one thing and how much I got to learn from my peers at Wesleyan. I think that other students are what make this place so special. Im glad that I really took advantage of getting to know everyone around me.

This interview has been edited for length and clarity.

Hallie Sternberg can be reached at hsternberg@wesleyan.edu.

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PacBio and UCLA Health Announce Research Collaboration for Whole Genome Sequencing in Rare Diseases – Stockhouse

Posted: at 7:19 pm

MENLO PARK, Calif., Dec. 07, 2021 (GLOBE NEWSWIRE) -- PacBio (Nasdaq: PACB), a leading provider of high-quality, highly accurate sequencing platforms, and the UCLA Institute for Precision Health and David Geffen School of Medicine at UCLA have formed a research collaboration to further identify the causes of rare diseases.

The study will leverage PacBio’s HiFi long-read sequencing technology for whole genome sequencing (WGS) to look at undiagnosed pediatric rare disease patients who have already been sequenced with short-read technology.

Dr. Stanley Nelson, Director, California Center for Rare Diseases, and professor, pathology and laboratory medicine and human genetics, David Geffen School of Medicine at UCLA, will be pioneering the combined use of full-length isoform sequencing (ISO-Seq) and long-read WGS in an effort to investigate the effect on diagnostic yield in these unresolved cases.

For rare disease patients, a genetic diagnosis always provides clarity to the whole family and can mean more effective treatments to avoid long-term complications,” explained Nelson. Within our undiagnosed diseases program at UCLA, approximately 50 percent of the rare disease patients we conduct short-read WGS on will still not have a DNA diagnosis. We hope that the knowledge we gain will allow us to reduce that number and give more families a diagnosis.”

We are excited to see the growing interest in PacBio’s HiFi sequencing as an important new tool for detecting large or challenging variants missed by short-read sequencing,” said Christian Henry, President and CEO of PacBio. We are proud to use our technology to support UCLA Health in their commitment to solving medical mysteries and helping to potentially reduce the time to diagnosis.”

To learn more about the benefits of HiFi sequencing in rare disease visit https://www.pacb.com/research-focus/human/rare-disease/.

About PacBio Pacific Biosciences of California, Inc. (NASDAQ: PACB) is empowering life scientists with highly accurate long-read sequencing. The company’s innovative instruments are based on Single Molecule, Real-Time (SMRT®) Sequencing technology, which delivers a comprehensive view of genomes, transcriptomes, and epigenomes, enabling access to the full spectrum of genetic variation in any organism. Cited in thousands of peer-reviewed publications, PacBio® sequencing systems are in use by scientists around the world to drive discovery in human biomedical research, plant and animal sciences, and microbiology. For more information, please visit http://www.pacb.com and follow @PacBio.

PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.

Forward-Looking Statements This press release may contain forward-looking statements” within the meaning of Section 21E of the Securities Exchange Act of 1934, as amended, and the U.S. Private Securities Litigation Reform Act of 1995, including statements relating to PacBio’s collaboration with UCLA Health to further identify causes of rare disease; anticipated efforts and outcomes in connection with such collaboration; and interest in and anticipated capabilities of PacBio’s products and technology, including in connection with the detection of genomic variants and helping to potentially reduce the time to diagnosis. Readers are cautioned not to place undue reliance on these forward-looking statements and any such forward-looking statements are qualified in their entirety by reference to the following cautionary statements. All forward-looking statements speak only as of the date of this press release and are based on current expectations and involve a number of assumptions, risks and uncertainties that could cause the actual results to differ materially from such forward-looking statements. Readers are strongly encouraged to read the full cautionary statements contained in the Company’s filings with the Securities and Exchange Commission, including the risks set forth in the company’s Forms 8-K, 10-K, and 10-Q. The Company disclaims any obligation to update or revise any forward-looking statements.

Contacts Investors: Todd Friedman ir@pacificbiosciences.com

Media: Kathy Lynch pr@pacificbiosciences.com

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Inspiring Young Female Doctors in the UAE and Beyond – APN News

Posted: at 7:19 pm

Published on December 10, 2021

SKMCs Dr. Shaden Abdelhadi shares the story of her prolific career and how support from SEHA is helping women working in healthcare achieve their dreams

Abu Dhabi Health Services Company (SEHA), the UAEs largest healthcare network, is continuing with its efforts to propel the careers of young and ambitious female doctors.

Setting an example of perseverance and sheer determination, coupled with excellence in her field, is Dr. Shaden Abdelhadi, FRCP (Edin), FAAD is an internationally trained Emirati Pediatric Dermatologist specializing in human genetic skin disorders at the Genetic Pediatric Dermatology Unit at Sheikh Khalifa Medical City (SKMC), part of SEHA.

Dr. Abdelhadi said: To women in medicine, I urge you to continue persevering, irrespective of the challenges you may encounter. Forge ahead and never lose sight of the patients whose health we strive to better every single day. I consider myself supremely lucky to have received the right support during my career. I joined SEHA in 2005 as a Staff Physician in the Department of Medicine at SKMC. The tremendous support I have received in terms of training, access to opportunities and resources, played a major contributing role in where I stand today as a dermatologist.

One of the most respected medical professionals working in her area of expertise, Dr. Abdelhadi acknowledges how education has shaped her career. I consider it an absolute privilege to have had such an extensive education. From becoming a Department of Health (DoH) Specialist through the Arab Board Dermatology Residency Program at SKMC in 2012, to gaining clinical training experience at the Childrens Hospital of Washington University in Seattle, and St. Thomas Hospital in London, every step has added a new dimension to my clinical understanding.

Gaining the Postgraduate Belgium Board Certificate in Pediatric Dermatology (2017) and the Interdisciplinary Board Certificate in Human Medical Genetics (2018) were both challenges that bolstered my self-confidence. In my line of work, real-world experience is an absolute necessity, and I am truly grateful for having received it through my fellowships with the Royal College of Physicians, Edinburgh; American Academy of Dermatology; European Academy of Dermatology and Venereology; and the European Society of Pediatric Dermatology.

Dr. Abdelhadi is currently a member of the International Society of Pediatric Dermatology and a member of the Editorial Board of Dermatologic Therapy, one of Europes leading scientific publications. She was recently elected to the UAE Dermatology Specialty Committee, which is leading the future of postgraduate education in dermatology in the UAE.

Despite having reached the zenith of professional success, Dr. Abdelhadi maintains there is no greater joy than to teach. What use is a wealth of knowledge if one isnt willing to share it? I am currently an Assistant Professor of Dermatology at the College of Medicine and Health Sciences, Khalifa University in Abu Dhabi, and a core faculty member at the Arab Board Dermatology Residency Program at SKMC. I thrive on the discussions I have with my students; it keeps adding a fresh perspective to my understanding of medicine.

I am passionate about disseminating national and international education in the treatment of pediatric dermatology and pediatric genetic skin diseases. In my opinion, medical education never ceases, you must constantly keep yourself updated. Since 2016, I have been the co-founder and Vice President of several annual international pediatric dermatology conferences precisely for this reason.

Dr. Abdelhadi is a leading figure in helping SEHA deliver excellence in healthcare. She has been instrumental in efforts to have the Arab Board Dermatology Residency Program at SKMC accredited by the American Council for Graduate Medical Education (ACGME), making it the worlds second US accredited dermatology residency program outside the USA. Furthermore, she also set up the UAEs first Multidisciplinary Epidermolysis Bullosa Center.

Speaking about the immense support she has received at SEHA, Dr. Abdelhadi said: SEHA has played a key role in my training and supported my ambition of becoming a uniquely specialized physician. With SEHA being a leader in medical education, I believe I can work closely with the National Institute of Health Sciences in better planning the medical specialties and sub-specialties the UAE needs.

Dr. Abdelhadis route to success, however, has not been without challenges, with slow and bureaucratic processes, changing priorities and decisions all hurdles that needed to be overcome.

There is no success without challenges, she said. To all the budding female doctors in the region, I hope my journey serves as a reminder that nothing is impossible if you have enough perseverance.

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Left and right take aim at Big Tech and the First Amendment | TheHill – The Hill

Posted: at 7:18 pm

Its open season on Americas digital media marketplace, withboththe left and right lining up to take regulatory shots at tech platforms, but for very different reasons. If both sides get their way, the result will be a more politicized media sector and unprecedented government interference with freedom of speech.

Facebook, Google, Twitter, Amazon and Apple have all become political pinatas for federal and state policymakers, with legislation and lawsuits launched seemingly on a weekly basis. But there is considerable confusion in the complaints both parties make about Big Tech.

Democrats want tech companies doing more to limit content they claim is hate speech, misinformation, or that incites violence. Republicans want online operators to do less, because many conservatives believe tech platforms already take down too much of their content.

The only thing unifying both sides is a desire for greater regulatory control of media. In todays hyper-partisan world, tech platforms have become just another plaything to be dominated by politics and regulation. When the ends justify the means, principles that transcend the battles of the day like property rights, free speech and editorial independence become disposable. These are things we take for granted until theyve been chipped away at and lost.

Is there any way to make both sides happy without undermining the digital economy, which has been dominated globally by American firms for over a quarter century?

Thats unlikely, but it hasnt stopped lawmakers from introducing a flurry of bills to weaken or eliminate protections afforded bySection 230, which limits liability for platforms that host user-generated content. Implemented in 1996, it has served asthe cornerstone of Americas ascendancyin the digital world andhelped spur an avalanche of innovation. Gutting it would put all that at risk.

Without admitting it, both sides are really at war against the First Amendment, which protects the editorial decisions made by private companies. To be sure, there is problematic content to be found on digital media platforms, and there aresome legitimate complaintsabout overzealous takedown policies and lack of transparent standards. That does not mean there is an easy policy fix to those problems, however. Butcourts have held repeatedlythat the First Amendment protects efforts by private media firms to devise their own approaches.Just last week, a Texas judge blocked a law that sought to limit social media platforms editorial freedoms. That followed a court in Floridaenjoining a similar lawthis summer.

Critics like to paint large tech companies as nefarious overlords out to destroy civilization. In reality, the problems we see and hear on modern platforms reflect deeper problems in our society. If these companies are to be blamed for anything, its making human communication so frictionless that every person now has a soapbox to speak to the world. Thats both a blessing and a curse. With unbounded speech comes many wonders but also many problems.

Now, large digital intermediaries are expected to make all those pathologies go away through some magical Goldilocks formula whereby they get content moderation just right. Its an impossible task with billions of voices speaking. Bureaucrats wont do a better job refereeing these disputes, and letting them do so will turn every content spat into an endless regulatory proceeding.

It is particularly surprising that someconservatives are joining the choruscalling for common carrier regulations orFairness Doctrine-like speech mandates, which would let government micromanage speech platforms. In this debate,they areinviting comprehensive political control of communications platforms, which is antithetical to a limited government philosophy.

Moreover, why would conservatives believe theyll benefit from more regulation? Even if one accepts the notion that social media platforms discriminate against conservative speakers or viewpoints, will freshly empowered bureaucrats really help them push private platform content moderation decisions in a more pro-conservative direction? The administrative state historicallyhas not been the friendof conservative viewpoints, and regulators are not suddenly going to become more sympathetic to them.

Theyd more likely be shooting themselves in the foot. There has never been more opportunity for conservative viewpoints than right now. Each day on Facebook, the top-10 most shared links aredominated by punditssuch as Ben Shapiro, Dan Bongino, Dinesh D'Souza and Sean HannitySean Patrick HannityLeft and right take aim at Big Tech and the First Amendment Rittenhouse says he's destroying gun used in fatal Kenosha shootings Dr. Oz expected to run for Senate in Pennsylvania as a Republican: reports MORE. Right-leaning content isshared widely on Twittereach day. Websites like Dailywire.com and Foxnews.comget far more trafficthan the New York Times or CNN.

Conservatives should push formore competition and choices,not more regulation and litigation. They should again embracethe vision President Reaganset forth in 1987, when he vetoed a bill to reestablish the Fairness Doctrine: History has shown that the dangers of an overly timid or biased press cannot be averted through bureaucratic regulation, but only through the freedom and competition that the First Amendment sought to guarantee.

It remains the principled path forward.

Adam Thiereris a senior research fellow at theMercatusCenter at George Mason University and author of Evasive Entrepreneurs and the Future of Governance.

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These 6 overvalued stocks are making the S&P 500 look more pricey than it really is – MarketWatch

Posted: at 7:18 pm

Its impossible to know which stocks will dominate the stock market in a decades time, but we can fairly confidently say which companies will not be on that list: stocks that currently top todays market-cap ranking namely Apple AAPL, +2.80%, Microsoft MSFT, +2.83%, Amazon.com AMZN, -1.12%, Alphabet (Google) GOOG, +0.38% and Meta Platforms (Facebook) FB, -0.02%.

Thats because its rare for stocks at the top of the market-cap ranking to keep their status a decade later. Not only do they usually fall out of the top 10, they also underperform the market on average over the decade.

Thats according to an analysis conducted by Research Affiliates, the investment firm headed by Robert Arnott. To show the precarious position of the markets top dogs, he calculated what happened over the decade of the 1980s to the 10 largest publicly traded companies at the beginning of that 10-year period. Eight of the 10 were not on 1990s top-10 list, and all 10 on 1980s list underperformed the world stock market over the subsequent decade.

Arnott found that the 1980s were not unique. He reached a similar result for the top stocks of the 1990s, 2000s, and 2010s. On average, a stock on any of these lists underperformed the market over the subsequent decade. In addition, there was between a 70% and 80% chance that any given stock would not be on the comparable list one decade hence.

Arnott illustrated these top companies underperformance in another way as well: He constructed a hypothetical portfolio that each year owned the worlds 10-largest companies. The performance of this portfolio is plotted in the chart below. Over the 40 years from the end of 1980 through the end of 2020, this portfolio lagged a buy-and-hold by 1.8 annualized percentage points.

Numerous investment lessons can be drawn from Arnotts fascinating results. One is that cap-weighting is not the optimal weighting scheme for your portfolio. Equal-weighting is one obvious alternative, and it has beaten cap-weighting: since 1971, according to data from S&P Dow Jones Indices, the equal-weighted version of the S&P 500 SPX, +0.95% has outperformed the cap-weighted version by 1.5 annualized percentage points.

Arnott believes there are even better ways of weighting stocks in an index beyond equal weighting. His firm maintains a number of so-called fundamental indices that base a stocks weight on fundamental characteristics such as sales, cash flow, dividends and book equity value.

Just six stocks Apple, Microsoft, Alphabet, Amazon, Tesla and Meta Platforms account for 26% of the S&P 500s total market cap

But theres another investment implication of Arnotts data that I want to focus on: His results highlight the difficulties determining the valuation of a lopsided market.

Consider the S&P 500 currently, in which just six stocks Apple, Microsoft, Alphabet, Amazon, Tesla TSLA, +1.32% and Meta Platforms account for 26% of the indexs total market cap. Imagine a situation in which those six are overvalued while the other 494 stocks, on balance, are more fairly valued. In that case, the valuation ratios for the S&P 500 as a whole could paint a skewed picture.

This situation isnt just hypothetical. The largest six stocks currently have an average price/earnings ratio of 62.0, according to FactSet, more than double the average across all stocks in the S&P 500 of 29.1 and almost triple its median P/E ratio of 21.4.

Its possible, therefore, that the stock market isnt as overvalued as we would otherwise think by focusing on valuation ratios for the S&P 500 as a whole.

Mark Hulbert is a regular contributor to MarketWatch. His Hulbert Ratings tracks investment newsletters that pay a flat fee to be audited. He can be reached at mark@hulbertratings.com

Become a smarter investor. Sign up hereto get MarketWatchs best mutual funds and ETF stories emailed to you weekly!

More: When should I sell Amazon? These pro tips can help you dump your stock market darlings

Also read: If the S&P 500 cant hit new highs, brace for fresh selling

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2010: Big Tech is watching you – Siliconrepublic.com

Posted: at 7:18 pm

The seeds of surveillance capitalism are starting to sprout while Stuxnet attacks, 3D TV flops, and a 2D game of flinging furious fowl is a runaway success.

Tweets were sent in their billions in 2010, and at least some of them were about Irish showband sensations Crystal Swing. This internet-famous group was not among the stellar line-up for the second Dublin Web Summit, but founders from Twitter, YouTube, Skype and Bebo were all invited for the Irish event and its new sister conference, Founders.

As US tech was reaching across the Atlantic and landing in Dublin, an ill wind that blew in from that side of the world had left Europe shuddering. The debt crisis that followed the financial crash was taking hold across the EU, and Ireland was among the worst hit. In late November, the EU agreed to an 85m bailout package to rescue the countrys failing financial sector.

The unemployment rate continued to trend upwards, but jobs were still being created in tech as more Irish outposts were established and growing. US analytics firm Dun & Bradstreet was among them.

Dun & Bradstreet opened its software and data operations centre in Dublin in 2010 with the express intent to leverage the technical talent in the Irish market, said Donal Cavanagh, the companys present-day Dublin site lead. In the intervening decade, we have seen both the explosion of data and the critical role data now plays in the successful running of any business. Everyone is looking for growth, to manage risk, to navigate ever-growing compliance directives. Today, in a world that is digitalised, the way to connect and control these is through data.

There was still plenty of money to be made in the age of big data and, as a new decade dawned, analysis and monitoring were moving beyond the commercial and into the personal lives of individuals.

Facebook was reaching new heights in 2010, hitting 500m users just over halfway through the year. Among them was about a third of the Irish population.

Facebook had become so mainstream it was taken to the big screen. Directed by David Fincher and penned by Aaron Sorkin, The Social Network wowed critics and topped the US box office. Facebook CEO Mark Zuckerberg said the film completely misrepresented the motivation behind the social media platform, but conceded that the costuming was fastidious. Every single shirt and fleece they had in that movie is actually a shirt or fleece that I own, he said.

Meanwhile, the subject matter of future Facebook documentaries was coming to the fore. At the January Crunchies awards in San Francisco, Zuckerberg made comments downplaying users desire for privacy. He was forced to eat his words in May after a glitch was found that could make users chat messages and pending friend requests visible if exploited, and a Wall Street Journal report claimed advertisers on platforms such as Facebook were using a privacy loophole to retrieve personal information.

Zuckerberg responded with an op-ed in the Washington Post announcing new privacy controls. The biggest message we have heard recently is that people want easier control over their information, he wrote, changing his tune from earlier in the year.

This became the holding pattern for Facebook privacy concerns for years to come, as the vast trove of information offered up by the platform presented just too tempting an opportunity for data mining. Indeed, this was the year the US National Security Agency started its large-scale social mapping programme, though that wouldnt be revealed until later. In the meantime, the man who made half a billion friends closed out 2010 as Time magazines Person of the Year and with almost $2bn in revenue.

Of course, Facebook wasnt the only tech company building a lucrative business on an abundant data mine.

Google was stirring up its own privacy-centred controversy in 2010, as it was revealed that the companys Street View mapping vehicles had captured more than they should have. (And not just the odd or inappropriate moments caught on camera.)

Street View had mapped Irelands major cities in 2009 and its cars returned the next year to fill in some gaps. This was after it had emerged that unauthorised code deployed by Street View captured data broadcast over unencrypted Wi-Fi networks in more than 30 countries. This prompted investigations in the US, Spain and the UK, while the Irish Government demanded that Google simply delete the data it had intercepted.

Eventually the US investigation was closed after Google promised to improve its internal procedures. The company also promised to delete the data it collected in the UK.

In Germany, Google agreed to allow residents to opt out of the service and have images of their homes blurred out. This, however, made these homes a target for vandals.

Street View launched in Ireland at the end of September, after its cars and pedal-powered trikes finished their intensive mapping of Dublin, Cork, Limerick, Galway and Waterford. It had reached all seven continents in 2010, and even photographed several penguin colonies in Antarctica.

While controversial in its roll-out, Google was right in thinking that Street View was something that people wanted to see. What viewers didnt want, however, was 3D TV.

Spurred on by the phenomenal success of James Camerons Avatar in December 2009, TV-makers and broadcasters threw their weight behind 3D entertainment in a big way.

Sky was the first network to announce a 3D TV channel for Ireland and the UK (and SiliconRepublic.com got a pre-launch sneak peek in 2009).Sony built one of the worlds first 3D outside broadcast trucksand, by March, Samsung and LG promised at-home sets. Irelands first 3D TV broadcast, a Premier League match between Manchester United and Chelsea, was made on 3 April adding a whole new dimension to watching sports.

That same month, Samsung pointed out that 3D TV might cause motion sickness, altered vision, disorientation, eye strain and instability, among other things.

Add that to the high cost and low content on 3D TV, and the market just wasnt adding up. Even though 3D TVs were shipping faster than HD TVs in November 2010, it wouldnt be long before most 3D TV sets and services were no longer available.

But with touch-enabled smartphones becoming ubiquitous, the demand for mobile gaming was at an all-time high. And along came Finnish game developer Rovio to take a (sling)shot at this trend.

Angry Birds launched in late 2009 at the height of the swine flu epidemic, hence the antagonist pigs. It quickly rose ranks in projectile motion to become the number-one iPhone game. When it finally arrived on Android, it scored more than 1m downloads in one day as more and more users flung themselves into the action.

The Android roll-out was slightly scuppered by the fragmentation of the Google mobile ecosystem, and this would become a common issue for the rival to Apples tightly controlled iOS. But its popularity held strong and, by year end, Angry Birds was top of the app charts another feather in its cap.

Another viral success of 2010 was far less charming. The Stuxnet computer worm was first detected in the summer, described as one of the most refined pieces of malware ever discovered.

The threat it posed became clear in September when it attacked Irans first nuclear power plant. While initially described as cyberterrorism, some experts felt it had to have been a state-sponsored cyberattack due to the worms sophisticated design.

Some saw Stuxnet as a new form of cyberwarfare. Within days, a major cybersecurity exercise was set to assess the vulnerability of vital services in the US and, later, the US military created a Cyber Command to protect its networks. However, security technologist Bruce Schneier said that threats of cyber war and terrorism were grossly exaggerated and were really hindering our understanding of online risks.

By the end of the year, Stuxnet code had made its way to underground forums, while threat reports and a former CIA director predicted the rise of cyberattacks in the future.

27 January: Apple unveils the iPad, a nine-inch tablet computer with all the capabilities of an iPhone, minus the phone.

16 February: At Mobile World Congress in Barcelona, Google CEO Eric Schmidt announces that the company is now pursuing a mobile first strategy.

23 March: LinkedIn connects with Dublin, announcing that it will establish its international headquarters in the Irish capital.

5 April: WikiLeaks publishes footage of a 2007 airstrike on Baghdad, which shows a US helicopter killing civilians.

30 April: Journalist Mark Little bases his social media news service Storyful (which he founded in January) at the National College of Ireland Business Incubation Centre, alongside Barracuda FX and Ian Luceys Lucey Technology.

6 May: A trillion-dollar stock market crash is triggered by a series of automated trading programs entering a feedback loop.

20 May: Scientists create the first synthetic cells in a project that took 15 years to complete.

22 May: In a big moment for bitcoins use, computer programmer Laszlo Hanyecz trades 10,000 bitcoin for two pizzas from Papa Johns. (At todays rate, those pizzas cost more than 210m each.)

27 May: Whistleblower Chelsea Manning is arrested by the US Armys Criminal Investigation Command.

11 June: The FIFA World Cup kicks off in South Africa and the deafening sound of vuvuzelas in the crowd inspires Irish start-up Restored Hearing to pitch its tinnitus treatment to football fans.

15 June: One day after the slim iPhone 4 with its high-definition Retina display is made available for pre-order, Apple and AT&T have already sold out of their initial stock.

24 June: Ergos financial software spin-off Fenergo raises 2m in funding from Enterprise Ireland and the European Investment Bank to go global.

16 July: Instagram co-founder Mike Krieger posts the platforms first photo: an artistically angled harbour view through a window. (The app would arrive on the App Store in October.)

25 July: WikiLeaks publishes a trove of more than 90,000 classified documents on US military action in Afghanistan.

10 August: Physicist Stephen Hawking says he believes that the long-term future of the human race must be in space.

10 August: The World Health Organization declares that the H1N1 swine flu pandemic is over after just over a year.

10 September: A transatlantic flight is grounded at Shannon Airport after a charging mobile phone overheated to the point of melting and emitting smoke, unbeknown to its owner.

4 October: Twitter co-founder Ev Williams announces that he will step down as CEO, to be replaced by COO Dick Costolo.

5 October: Andre Geim and Konstantin Novoselov are jointly awarded the Nobel Prize in Physics for their groundbreaking graphene discovery from 2004.

9 October: Google announces that its self-driving cars have clocked more than 140,000 miles.

11 October: The Big Four record labels EMI, Sony, Warner and Universal fail in their bid to secure an injunction against UPC to implement a three-strike rule for illegal file-sharing.

22 October: The International Space Station outstrips Mir for the record of the longest continuous human occupation in space, passing its 3,641st day.

28 October: Chinas Tianhe-1A, packed with more than 14,000 Intel Xeon processors and more than 7,000 Nvidia Tesla GPUs, is dubbed the worlds top supercomputer with the capability to perform 2,507trn calculations each second.

10 November: Microsoft launches the Kinect for Xbox 360 in Ireland with some help from Sophie Ellis-Bextor.

17 November: Researchers at CERN trap antimatter for the first time (for a sixth of a second).

18 November: Camara recycles its 20,000th computer in Ireland.

28 November: WikiLeaks publishes a collection of more than 250,000 US diplomatic cables.

16 December: Following an international arrest warrant issued by Swedish police over allegations of sexual misconduct, WikiLeaks founder Julian Assange is released on bail from a second extradition hearing in the UK.

17 December: Reports emerge that Twitter is considering Dublin as the site of its European HQ.

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Alphabet Is The Best Value In Big Tech – Motley Fool

Posted: at 7:18 pm

Alphabet, Inc (NASDAQ:GOOGL) is a worldwide digital advertising and cloud services company. The company operates in three segments; Google Services, Google Cloud, and Other Bets. The stock has gained 62% year-to-date and 276% over the past five years.

Source: Getty Images

We all know Google, right? Need a sports score? Google it. Migratory habits of penguins? Google it. Need to see Alphabet's financial statements? You got it -- just Google it. But some of us may not be clear just how and from where Google generates its revenues. The vast majority of their revenue comes from advertisements related to Google Search, as shown below in the disaggregation of the company's revenue for the first three quarters of 2020 and 2021.

When one searches on Google, the ads shown on top are often "pay-per-click" advertisements. This means that the advertisers bid for the top ad space, and then pay Alphabet whenever someone clicks on the ad. This is very effective advertising as consumers who perform a search are often ready to buy. As shown in the table above, Google makes 58% of its revenue from search advertising. This revenue was up more than 46% year-over-year for the first nine months of 2021. This is an impressive showing, however not as impressive as the 57% year-over-year gain made by YouTube ads. More and more consumers are cutting the cord each year and YouTube benefits from this trend in a major way.

The Google Cloud is an exciting element although it currently only makes up 7% of revenues. Google Cloud has a long growth runway and related revenue was up 48% year-over-year. The Cloud Services market is currently dominated by Amazon's (NASDAQ:AMZN) Amazon Web Services and Microsoft (NASDAQ:MSFT) Azure . However, the total addressable market for cloud infrastructure is expected to surpass $150 billion in 2021, a 37% increase over 2020. Amazon makes up 32% of the market and Microsoft 20%. After this, several companies jockey for position with Google leading at 9% market share. With the total market growing this year by more than 30%, this is a massive opportunity for growth for Google.

Revenues at Google continue to expand impressively and are expected to reach more than $254 billion for the 2021 fiscal year. This is an increase of 39% over the pandemic tempered 2020.

SOURCE: ALPHABET

As shown above, the pandemic led to tepid growth in 2020 which has roared back in 2021, effectively filling the gap. Over the past five years revenues have grown at a compound annual rate of 23%. Margins are also healthy with the company posting an EBITDA margin of 36% over the trailing twelve months and an operating margin of 30% over this time. Both are up from 2020 where the company posted 30% and 23%, respectively.

Of the Big Tech giants who are Google competitors, only Meta Platforms, formerly Facebook, (NASDAQ:FB) has more attractive valuation metrics. This is due to the recent whistleblower accusations against Meta Platforms which have caused the stock to swoon. Meta Platforms also makes the majority of its revenue from advertising, while Amazon and Microsoft compete with Google in the cloud and advertising markets.

SOURCE: YCHARTS

Google has a very reasonable forward PE of 26.5, shown above, which suggests there is still considerable upside in the stock, especially given the expected growth. The EV to EBITDA ratio is even more attractive at 16.8. This is due to the fortress balance sheet that Google maintains. The company had $142 billion in cash and short-term investments at last report with just $12.8 billion in long-term debt. The cash and short-term investments on hand represent a whopping 7.5% of the $1.88 trillion market cap.

Google has made tremendous gains in its core advertising business year-over-year and more is expected as we turn to 2022. Search and YouTube will continue to lead the way, however the company also has a tremendous opportunity in the cloud services segment. Margins are expanding and the company maintains an impressive balance sheet. Google is being overlooked by investors judging by its modest valuation ratios. All of this adds up to tremendous value and an exceptional opportunity for long-term investors to gain an edge.

This article represents the opinion of the writer, who may disagree with the official recommendation position of a Motley Fool premium advisory service. Were motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.

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We shouldnt be proud of Indians dominating Big Tech – The Times of India Blog

Posted: at 7:18 pm

With Parag Agrawal becoming Twitter CEO, now a number of Big Tech companies are headed by persons of Indian origin. Unsurprisingly, a wave of patriotism has swept across India. These people have done India proudthat is the common refrain. But that may not be true, for Big Tech today is the enemy of free speech; and Indians helping curb liberty can never be a matter of pride for their country.

To put things in perspective, lets consider the case of Jayaprakash Narayan. He can be lauded as a hero because he fought against authoritarianism during the Emergency (1975-77). But we can never and should never eulogize the otherwise admirable people for having colluded with tyranny at that time.

Big Tech is not without achievements; it has brought the gains of technology to billions of people. But it is also colluding with the enemies of freedom; this was the reason that Twitter de-platformed former US President Donald Trump, who is the greatest world leader of this century, for he is the biggest enemy of China, the most powerful and dangerous rogue state.

Social media giants censored and downplayed a lot of content that was anti-China. Concomitantly, they promoted a great deal that suited Beijing, the most important being their unflinching support to the theory that the novel coronavirus was of natural origin.

This helped a bunch of scientists to manipulate global opinionby way of a letter to the reputed medical journalLancetfor over a year into accepting the natural origin theory of the coronavirus. It was only on May 5 this year that the prominent science journalist Nicholar Wade challenged the natural origin orthodoxy (https://thebulletin.org/2021/05/the-origin-of-covid-did-people-or-nature-open-pandoras-box-at-wuhan/). The possibility of the virus birth in a lab got a leg up.

Wade also hinted at a concerted endeavor, if not a global conspiracy, aimed at proving that the origin of the novel coronavirus was natural. The recent developments not only underline the disingenuousness of some dishonest scientists but also the credulity of intellectuals all over the world who unquestioningly accepted the scientists lies as gospel.

In an article in the prestigious magazineThe Bulletin of Atomic Scientists, Wade talked about the thought leaders anti-Trump obsession supporting the natural origin theory which helped the Chinese. Another reason [for the acceptance of the natural origin theory], perhaps, is the migration of much of the media toward the left of the political spectrum. Because [former US] President [Donald] Trump said the virus had escaped from a Wuhan lab, editors gave the idea little credence. They joined the virologists in regarding lab escape as a dismissible conspiracy theory.

Wade said that at that time it was really far too soon for anyone to be sure what had happened. Yet, the scientists overwhelmingly conclude[d] that this coronavirus originated in wildlife.

The scientifically unsubstantiated assertion became an indubitable fact; and anyone, from conservative American politicians to dissenting scientists, questioning the novel coronavirus natural origin was accused of peddling a conspiracy theory. Trump and his political allies were of course hauled over the coals, but even credentialed experts were silenced. Like Chinese virologist Li-Meng Yan, who is now in the US. In September last year, Twitter suspended her account for the unpardonable sin of saying in public that China had manufactured the coronavirus in a Wuhan lab.

While the mainstream media and Big Tech acted like the Inquisition to support China, no one bothered to check the intentions of the scientists who had emphatically asserted the natural origin theory. According to Wade, It later turned out that the Lancet letter had been organized and drafted by Peter Daszak, president of the EcoHealth Alliance of New York. Daszaks organization funded coronavirus research at the Wuhan Institute of Virology. If the SARS2 virus had indeed escaped from research he funded, Daszak would be potentially culpable. This acute conflict of interest was not declared to the Lancets readers. To the contrary, the letter concluded, We declare no competing interests.

Daszak, a devious manipulator, took the world for a ride for more than a yearto help the Chinese Communist Party. Just as he and others did to send American taxpayers money to the Wuhan Institute of Virology. According to Wade, From June 2014 to May 2019, Daszaks EcoHealth Alliance had a grant from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health [of the US], to do gain-of-function research with coronaviruses at the Wuhan Institute of Virology. Whether or not SARS2 is the product of that research, it seems a questionable policy to farm out high-risk research to foreign labs using minimal safety precautions. And if the SARS2 virus did indeed escape from the Wuhan institute, then the NIH will find itself in the terrible position of having funded a disastrous experiment that led to the death of more than 3 million worldwide, including more than half a million of its own citizens.

The propagation of a fake theory is just one consequence of the suppression of free speech by Big Tech and the mainstream media. Therefore, the fact that top executives in most Big Tech firms are Indians is not something we should be proud of.

Views expressed above are the author's own.

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Big Tech’s private networks and protocols threaten the ‘net, say internet registries – The Register

Posted: at 7:18 pm

The internet remains resilient, and its underlying protocols and technologies dominate global networking but its relevance may be challenged by the increasing amount of traffic carried on private networks run by Big Tech, or rules imposed by governments.

So says a Study on the Internet's Technical Success Factors commissioned by APNIC and LACNIC the regional internet address registries for the AsiaPacific and Latin America and Caribbean regions respectively and written by consultancy Analysys Mason.

Presented on Wednesday at the 2021 Internet Governance Forum (IGF), the study identifies four reasons the internet has succeeded:

The study also argues that the early designers of the internet incorporated three critical guiding ideals: openness, simplicity, and decentralization. These ideals were applied across three design principles: layering, creating a network of networks, and the end-to-end principle that sees intelligence placed at the network edge rather than the core.

The end-to-end principle matters, because it means applications can be installed in connected devices without the need to change any networks.

Much of the study fondly recalls how the abovementioned elements have delivered decades of useful innovation.

A significant fraction of global traffic is now moved between the datacentres and edge networks of large internet companies

The document also identifies risks.

A section on technical challenges to the success of the internet points out that the architecture has weak points, and that technologies to harden them aren't being strongly adopted.

"While both DNSSEC and the BGP security extensions are important steps towards securing the internet infrastructure, significant efforts will still be needed before these protocols are widely deployed and used. Significant efforts will still be needed," the study warns.

The lack of a proper quality of service (QoS) standard is also called out, because its absence has created "concerns that the best-effort model will not be sufficient to support the needs of emerging interdomain applications such as augmented/virtual reality or interactive gaming".

Imposing a QoS standard would threaten the network-of-networks principle, the study states, adding that any attempt to change internet protocols would likely be rejected if only because the world has sunk so much effort into current networks.

But the study identifies some players that could decide to go their own way: "social media companies, video streaming companies, CDNs and cloud companies".

The document states that "a significant fraction of global IP traffic now consists of data that is moved between the datacentres and edge networks of large internet companies."

Those companies' needs, and growing networks, lead the analysts to suggest that "over time, we could see the internet transform into a more centralised system with a few global private networks carrying most of the content and services.

"In this scenario, what remains outside these private networks are primarily ISP networks that move traffic to and from end users, and the user experience would be shaped by how close a user sits to the private network of the relevant internet company.

The study also suggests Big Tech could research protocols it needs, and by doing so take resources away from work on open internet protocols. While any such work would need to be interoperable with the wider internet, and therefore preserve the network-of-networks principle the document cites development of the TCP-alternative QUIC protocol as an example of a successful private technology push it also suggests "increased centralisation could blur the distinction between network and applications, as expressed in the layering principle."

Another risk is that when private networks break, many users suffer. Exhibit A: yesterday's AWS brownout, which hurt Netflix and Disney+, among others.

The study also identifies governance issues as an emerging risk especially when nations seek to impose their own requirements on the internet.

"A development where governments gain more control over the development of the internet may involve a risk of a more fragmented system, without the common address space and global reachability we have today."

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We have no intention of becoming a bank: Is Big Tech really a threat to banks? Tearsheet – Tearsheet

Posted: at 7:18 pm

When big technology companies start to expand into different industries, they are quick to be labelled as disruptive. In the financial services sector, the circulating rhetoric has been that Big Tech is coming into the industry as a unilateral force to compete with banks.

The industry tends to talk about this kind of big tech threat as one overarching problem, and I think thats really the wrong characterization, Kate Drew, director of research at CCG Catalyst told Tearsheet.

Big Tech is a nickname given to the five biggest technology companies in the world: Apple, Google, Facebook, Amazon and Microsoft. While Microsoft just recently announced its first consumer fintech move by adding BNPL into its browser, the other four are all more established players in the space.

The sheer size and capabilities of these companies can be intimidating, as is their advantage of having an existing user base of millions of people to offer banking products to. However, the oftentimes overlooked factor is the underlying strategy behind their expansion which, upon a closer look, suggests that direct competition with banks is not really on their main agenda.

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