Daily Archives: November 19, 2021

Louis Pasteur (18221895) is revered by his successors in the life sciences as well as by the general public. In fact, his name provided the basis for a household wordpasteurized.

His research, which showed that microorganisms cause both fermentation and disease, supported the germ theory of disease at a time when its validity was still being questioned. In his ongoing quest for disease treatments he created the first vaccines for fowl cholera; anthrax, a major livestock disease that in recent times has been used against humans in germ warfare; and the dreaded rabies.

Pasteur was born in Dole, France, the middle child of five in a family that had for generations been leather tanners. Young Pasteurs gifts seemed to be more artistic than academic until near the end of his years in secondary school. Spurred by his mentors encouragement, he undertook rigorous studies to compensate for his academic shortcomings in order to prepare for the cole Normale Suprieure, the famous teachers college in Paris. He earned his masters degree there in 1845 and his doctorate in 1847.

While waiting for an appropriate appointment Pasteur continued to work as a laboratory assistant at the cole Normale. There he made further progress on the research he had begun for his doctoral dissertationinvestigating the ability of certain crystals or solutions to rotate plane-polarized light clockwise or counterclockwise, that is, to exhibit optical activity. He was able to show that in many cases this activity related to the shape of the crystals of a compound. He also reasoned that there was some special internal arrangement to the molecules of such a compound that twisted the lightan asymmetric arrangement. This hypothesis holds an important place in the early history of structural chemistrythe field of chemistry that studies the three-dimensional characteristics of molecules.

Pasteur secured his academic credentials with scientific papers on this and related research and was then appointed in 1848 to the faculty of sciences in Strasbourg and in 1854 to the faculty in Lille. There he launched his studies on fermentation. Pasteur sided with the minority view among his contemporaries that each type of fermentation is carried out by a living microorganism. At the time the majority believed that fermentation was spontaneously generated by a series of chemical reactions in which enzymesthemselves not yet securely identified with lifeplayed a critical role.

In 1857 Pasteur returned to the cole Normale as director of scientific studies. In the modest laboratory that he was permitted to establish there, he continued his study of fermentation and fought long, hard battles against the theory of spontaneous generation. Figuring prominently in early rounds of these debates were various applications of his pasteurization process, which he originally invented and patented (in 1865) to fight the diseases of wine. He realized that these were caused by unwanted microorganisms that could be destroyed by heating wine to a temperature between 60 and 100C. The process was later extended to all sorts of other spoilable substances, such as milk.

At the same time Pasteur began his fermentation studies, he adopted a related view on the cause of diseases. He and a minority of other scientists believed that diseases arose from the activities of microorganismsgerm theory. Opponents believed that diseases, particularly major killer diseases, arose in the first instance from a weakness or imbalance in the internal state and quality of the afflicted individual. In an early foray into the causes of particular diseases, in the 1860s, Pasteur was able to determine the cause of the devastating blight that had befallen the silkworms that were the basis for Frances then-important silk industry. Surprisingly, he found that the guilty parties were two microorganisms rather than one.

Pasteur did not, however, fully engage in studies of disease until the late 1870s, after several cataclysmic changes had rocked his life and that of the French nation. In 1868, in the middle of his silkworm studies, he suffered a stroke that partially paralyzed his left side. Soon thereafter, in 1870, France suffered a humiliating defeat at the hands of the Prussians, and Emperor Louis-Napolon was overthrown. Nevertheless, Pasteur successfully concluded with the new government negotiations he had begun with the emperor. The government agreed to build a new laboratory for him, to relieve him of administrative and teaching duties, and to grant him a pension and a special recompense in order to free his energies for studies of diseases.

In his research campaign against disease Pasteur first worked on expanding what was known about anthrax, but his attention was quickly drawn to fowl cholera. This investigation led to his discovery of how to make vaccines by attenuating, or weakening, the microbe involved. Pasteur usually refreshed the laboratory cultures he was studyingin this case, fowl choleraevery few days; that is, he returned them to virulence by reintroducing them into laboratory chickens with the resulting onslaught of disease and the birds death. Months into the experiments, Pasteur let cultures of fowl cholera stand idle while he went on vacation. When he returned and the same procedure was attempted, the chickens did not become diseased as before. Pasteur could easily have deduced that the culture was dead and could not be revived, but instead he was inspired to inoculate the experimental chickens with a virulent culture. Amazingly, the chickens survived and did not become diseased; they were protected by a microbe attenuated over time.

Realizing he had discovered a technique that could be extended to other diseases, Pasteur returned to his study of anthrax. Pasteur produced vaccines from weakened anthrax bacilli that could indeed protect sheep and other animals. In public demonstrations at Pouilly-le-Fort before crowds of observers, twenty-four sheep, one goat, and six cows were subjected to a two-part course of inoculations with the new vaccine, on May 5, 1881, and again on May 17. Meanwhile a control group of twenty-four sheep, one goat, and four cows remained unvaccinated. On May 31 all the animals were inoculated with virulent anthrax bacilli, and two days later, on June 2, the crowd reassembled. Pasteur and his collaborators arrived to great applause. The effects of the vaccine were undeniable: the vaccinated animals were all alive. Of the control animals all the sheep were dead except three wobbly individuals who died by the end of the day, and the four unprotected cows were swollen and feverish. The single goat had expired too.

Pasteur then wanted to move into the more difficult area of human disease, in which ethical concerns weighed more heavily. He looked for a disease that afflicts both animals and humans so that most of his experiments could be done on animals, although here too he had strong reservations. Rabies, the disease he chose, had long terrified the populace, even though it was in fact quite rare in humans. Up to the time of Pasteurs vaccine, a common treatment for a bite by a rabid animal had been cauterization with a red-hot iron in hopes of destroying the unknown cause of the disease, which almost always developed anyway after a typically long incubation period.

Rabies presented new obstacles to the development of a successful vaccine, primarily because the microorganism causing the disease could not be specifically identified; nor could it be culturedin vitro (in the laboratory and not in an animal). As with other infectious diseases, rabies could be injected into other species and attenuated. Attenuation of rabies was first achieved in monkeys and later in rabbits. Meeting with success in protecting dogs, even those already bitten by a rabid animal, on July 6, 1885, Pasteur agreed with some reluctance to treat his first human patient, Joseph Meister, a nine-year-old who was otherwise doomed to a near-certain death. Success in this case and thousands of others convinced a grateful public throughout the world to make contributions to the Institut Pasteur. It was officially opened in 1888 and continues as one of the premier institutions of biomedical research in the world. Its tradition of discovering and producing vaccines is carried on today by the pharmaceutical company Sanofi Pasteur.

Pasteurs career shows him to have been a great experimenter, far less concerned with the theory of disease and immune response than with dealing directly with diseases by creating new vaccines. Still it is possible to discern his notions on the more abstract topics. Early on he linked the immune response to the biological, especially nutritional, requirements of the microorganisms involved; that is, the microbe or the attenuated microbe in the vaccine depleted its food source during its first invasion, making the next onslaught difficult for the microbe. Later he speculated that microbes could produce chemical substances toxic to themselves that circulated throughout the body, thus pointing to the use of toxins and antitoxins in vaccines. He lent support to another view by welcoming to the Institut Pasteur lie Metchnikoff and his theory that phagocytes in the bloodwhite corpusclesclear the body of foreign matter and are the prime agents of immunity.

The information contained in this biography was last updated on December 14, 2017.

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Louis Pasteur | Science History Institute

1763 war launched by Native Americans against the British Empire in North America

Pontiac's War (also known as Pontiac's Conspiracy or Pontiac's Rebellion) was launched in 1763 by a loose confederation of American Indians dissatisfied with British rule in the Great Lakes region following the French and Indian War (17541763). Warriors from numerous tribes joined in an effort to drive British soldiers and settlers out of the region. The war is named after Odawa leader Pontiac, the most prominent of many Indian leaders in the conflict.

The war began in May 1763 when Native Americans, alarmed by policies imposed by British General Jeffrey Amherst, attacked a number of British forts and settlements. Eight forts were destroyed, and hundreds of colonists were killed or captured, with many more fleeing the region. Hostilities came to an end after British Army expeditions in 1764 led to peace negotiations over the next two years. The Natives were unable to drive away the British, but the uprising prompted the British government to modify the policies that had provoked the conflict.

Warfare on the North American frontier was brutal, and the killing of prisoners, the targeting of civilians, and other atrocities were widespread. In an incident that became well-known and frequently debated, British officers at Fort Pitt attempted to infect besieging Indians with blankets that had been exposed to smallpox. The ruthlessness of the conflict was a reflection of a growing racial divide between British colonists and Native Americans. The British government sought to prevent further racial violence by issuing the Royal Proclamation of 1763, which created a boundary between colonists and Natives.

The conflict is named after its most well-known participant, the Odawa leader named Pontiac. An early name for the war was the "Kiyasuta and Pontiac War," "Kiaysuta" being an alternate spelling for Guyasuta, an influential Seneca/Mingo leader. The war became widely known as "Pontiac's Conspiracy" after the 1851 publication of Francis Parkman's The Conspiracy of Pontiac. Parkman's book was the definitive account of the war for nearly a century and is still in print.

In the 20th century, some historians argued that Parkman exaggerated the extent of Pontiac's influence in the conflict, so it was misleading to name the war after him. Francis Jennings (1988) wrote that "Pontiac was only a local Ottawa war chief in a 'resistance' involving many tribes." Alternate titles for the war have been proposed, such as "Pontiac's War for Indian Independence," the "Western Indians' Defensive War" and "The Amerindian War of 1763." Historians generally continue to use "Pontiac's War" or "Pontiac's Rebellion," with some 21st century scholars arguing that 20th century historians had underestimated Pontiac's importance.

You think yourselves Masters of this Country, because you have taken it from the French, who, you know, had no Right to it, as it is the Property of us Indians.

Nimwha, Shawnee diplomat, to George Croghan, 1768

In the decades before Pontiac's War, France and Great Britain participated in a series of wars in Europe that involved the French and Indian Wars in North America. The largest of these wars was the worldwide Seven Years' War, in which France lost New France in North America to Great Britain. Most fighting in the North American theater of the war, generally called the French and Indian War in the United States, or the War of Conquest (French: Guerre de la Conqute) in French Canada, came to an end after British General Jeffrey Amherst captured French Montral in 1760.[24]

British troops occupied forts in the Ohio Country and Great Lakes region previously garrisoned by the French. Even before the war officially ended with the Treaty of Paris (1763), the British Crown began to implement policy changes to administer its vastly expanded American territory. The French had long cultivated alliances among Indian tribes, but the British post-war approach essentially treated Indians as a conquered people. Before long, Indians found themselves dissatisfied with the British occupation.

American Indians involved in Pontiac's War lived in a vaguely defined region of New France known as the pays d'en haut ("the upper country"), which was claimed by France until the Paris peace treaty of 1763. Indians of the pays d'en haut were from many different tribes. These tribes were linguistic or ethnic groups rather than political units; no chief spoke for an entire tribe, and no tribe acted in unison. For example, Ottawas did not go to war as a tribe: some Ottawa leaders chose to do so, while other Ottawa leaders denounced the war and stayed clear of the conflict.

The tribes of the pays d'en haut consisted of three basic groups. The first group was composed of tribes of the Great Lakes region: Ottawas, Ojibwes, and Potawatomis, who spoke Algonquian languages, and Hurons, who spoke an Iroquoian language. They had long been allied with French habitants with whom they lived, traded, and intermarried. Great Lakes Indians were alarmed to learn they were under British sovereignty after the French loss of North America. When a British garrison took possession of Fort Detroit from the French in 1760, local Indians cautioned them that "this country was given by God to the Indians." When the first Englishman reached Fort Michilimackinac, Ojibwe chief Minavavana told him "Englishman, although you have conquired the French, you have not yet conquered us!"

The second group was made up of tribes from eastern Illinois Country, which included Miamis, Weas, Kickapoos, Mascoutens, and Piankashaws. Like the Great Lakes tribes, these people had a long history of close relations with the French. Throughout the war, the British were unable to project military power into the Illinois Country, which was on the remote western edge of the conflict. The Illinois tribes were the last to come to terms with the British.[30]

The third group consisted of tribes of the Ohio Country: Delawares (Lenape), Shawnees, Wyandots, and Mingos. These people had migrated to the Ohio valley earlier in the century to escape British, French, and Iroquois domination. Unlike the Great Lakes and Illinois Country tribes, Ohio tribes had no great attachment to the French regime, though they had fought as French allies in the previous war in an effort to drive away the British. They made a separate peace with the British with the understanding that the British Army would withdraw. But after the departure of the French, the British strengthened their forts rather than abandoning them, and so the Ohioans went to war in 1763 in another attempt to drive out the British.

Outside the pays d'en haut, the influential Iroquois did not, as a group, participate in Pontiac's War because of their alliance with the British, known as the Covenant Chain. However, the westernmost Iroquois nation, the Seneca tribe, had become disaffected with the alliance. As early as 1761, Senecas began to send out war messages to the Great Lakes and Ohio Country tribes, urging them to unite in an attempt to drive out the British. When the war finally came in 1763, many Senecas were quick to take action.

General Jeffrey Amherst, the British commander-in-chief in North America, was in charge of administering policy towards American Indians, which involved military matters and regulation of the fur trade. Amherst believed with France out of the picture, the Indians would have to accept British rule. He also believed they were incapable of offering any serious resistance to the British Army, and therefore, of the 8,000 troops under his command in North America, only about 500 were stationed in the region where the war erupted. Amherst and officers such as Major Henry Gladwin, commander at Fort Detroit, made little effort to conceal their contempt for Indians; those involved in the uprising frequently complained that the British treated them no better than slaves or dogs.

Additional Indian resentment came from Amherst's decision in February 1761 to cut back on gifts given to the Indians. Gift giving had been an integral part of the relationship between the French and the tribes of the pays d'en haut. Following an Indian custom that carried important symbolic meaning, the French gave presents (such as guns, knives, tobacco, and clothing) to village chiefs, who distributed them to their people. The chiefs gained stature this way, enabling them to maintain the alliance with the French. The Indians regarded this as "a necessary part of diplomacy which involved accepting gifts in return for others sharing their lands." Amherst considered this to be bribery that was no longer necessary, especially as he was under pressure to cut expenses after the war. Many Indians regarded this change in policy as an insult and an indication the British looked upon them as conquered people rather than as allies.

Amherst also began to restrict the amount of ammunition and gunpowder that traders could sell to Indians. While the French had always made these supplies available, Amherst did not trust Indians, particularly after the "Cherokee Rebellion" of 1761, in which Cherokee warriors took up arms against their former British allies. The Cherokee war effort had failed due to a shortage of gunpowder; Amherst hoped future uprisings could be prevented by limiting its distribution.[43] This created resentment and hardship because gunpowder and ammunition helped Indians provide food for their families and skins for the fur trade. Many Indians believed the British were disarming them as a prelude to war. Sir William Johnson, the Superintendent of the Indian Department, warned Amherst of the danger of cutting back on presents and gunpowder, to no avail.

Land was also an issue in the coming of Pontiac's War. While the French colonists had always been relatively few, there seemed to be no end of settlers in the British colonies. Shawnees and Delawares in the Ohio Country had been displaced by British colonists in the east, and this motivated their involvement in the war. Indians in the Great Lakes region and the Illinois Country had not been greatly affected by white settlement, although they were aware of the experiences of tribes in the east. Dowd (2002) argues that most Indians involved in Pontiac's War were not immediately threatened with displacement by white settlers, and that historians have overemphasized British colonial expansion as a cause of the war. Dowd believes that the presence, attitude, and policies of the British Army, which the Indians found threatening and insulting, were more important factors.

Also contributing to the outbreak of war was a religious awakening which swept through Indian settlements in the early 1760s. The movement was fed by discontent with the British as well as food shortages and epidemic disease. The most influential individual in this phenomenon was Neolin, known as the "Delaware Prophet," who called upon Indians to shun the trade goods, alcohol, and weapons of the colonists. Melding Christian doctrines with traditional Indian beliefs, Neolin said the Master of Life was displeased with Indians for taking up the bad habits of white men, and that the British posed a threat to their very existence. "If you suffer the English among you," said Neolin, "you are dead men. Sickness, smallpox, and their poison [alcohol] will destroy you entirely." It was a powerful message for a people whose world was being changed by forces that seemed beyond their control.

Although fighting in Pontiac's War began in 1763, rumors reached British officials as early as 1761 that discontented American Indians were planning an attack. Senecas of the Ohio Country (Mingos) circulated messages ("war belts" made of wampum) calling for the tribes to form a confederacy and drive away the British. The Mingos, led by Guyasuta and Tahaiadoris, were concerned about being surrounded by British forts. Similar war belts originated from Detroit and the Illinois Country. The Indians were not unified, and in June 1761, natives at Detroit informed the British commander of the Seneca plot. William Johnson held a large council with the tribes at Detroit in September 1761, which provided a tenuous peace, but war belts continued to circulate. Violence finally erupted after the Indians learned in early 1763 of the imminent French cession of the pays d'en haut to the British.

The war began at Fort Detroit under the leadership of Pontiac and quickly spread throughout the region. Eight British forts were taken; others, including Fort Detroit and Fort Pitt, were unsuccessfully besieged. Francis Parkman's The Conspiracy of Pontiac portrayed these attacks as a coordinated operation planned by Pontiac. Parkman's interpretation remains well known, but later historians argued there is no clear evidence the attacks were part of a master plan or overall "conspiracy."[note 1] Rather than being planned in advance, modern scholars believe the uprising spread as word of Pontiac's actions at Detroit traveled throughout the pays d'en haut, inspiring discontented Indians to join the revolt. The attacks on British forts were not simultaneous: most Ohio Indians did not enter the war until nearly a month after Pontiac began the siege at Detroit.

Early historians believed French colonists had secretly instigated the war by stirring up the Indians to make trouble for the British. This belief was held by British officials at the time, but subsequent historians found no evidence of official French involvement in the uprising.[note 2] According to Dowd (2002), "Indians sought French intervention and not the other way around." Indian leaders frequently spoke of the imminent return of French power and the revival of the Franco-Indian alliance; Pontiac even flew a French flag in his village. Indian leaders apparently hoped to inspire the French to rejoin the struggle against the British. Although some French colonists and traders supported the uprising, the war was launched by American Indians for their own objectives.

Middleton (2007) argues that Pontiac's vision, courage, persistence, and organizational abilities allowed him to activate an unprecedented coalition of Indian nations prepared to fight against the British. Tahaiadoris and Guyasuta originated the idea to gain independence for all Indians west of the Allegheny Mountains, although Pontiac appeared to embrace the idea by February 1763. At an emergency council meeting, he clarified his military support of the broad Seneca plan and worked to galvanize other tribes into the military operation he helped to lead, in direct contradiction to traditional Indian leadership and tribal structure. He achieved this coordination through the distribution of war belts, first to the northern Ojibwa and Ottawa near Michilimackinac, and then to the Mingo (Seneca) on the upper Allegheny River, the Ohio Delaware near Fort Pitt, and the more westerly Miami, Kickapoo, Piankashaw, and Wea peoples.

Pontiac spoke at a council on the banks of the Ecorse River on April 27, 1763, about 10 miles (15km) southwest of Detroit. Using the teachings of Neolin to inspire his listeners, Pontiac convinced a number of Ottawas, Ojibwas, Potawatomis, and Hurons to join him in an attempt to seize Fort Detroit. On May 1, he visited the fort with 50 Ottawas to assess the strength of the garrison. According to a French chronicler, in a second council Pontiac proclaimed:

It is important for us, my brothers, that we exterminate from our lands this nation which seeks only to destroy us. You see as well as I that we can no longer supply our needs, as we have done from our brothers, the French.... Therefore, my brothers, we must all swear their destruction and wait no longer. Nothing prevents us; they are few in numbers, and we can accomplish it.

On May 7, Pontiac entered Fort Detroit with about 300 men carrying concealed weapons, hoping to take the stronghold by surprise. The British had learned of his plan, however, and were armed and ready.[note 3] His strategy foiled, Pontiac withdrew after a brief council and, two days later, laid siege to the fort. He and his allies killed British soldiers and settlers they found outside of the fort, including women and children. They ritually cannibalized one of the soldiers, as was the custom in some Great Lakes Indian cultures. They directed their violence at the British and generally left French colonists alone. Eventually more than 900 warriors from a half-dozen tribes joined the siege.[79]

After receiving reinforcements, the British attempted to make a surprise attack on Pontiac's encampment. Pontiac was ready and defeated them at the Battle of Bloody Run on July 31, 1763. The situation remained a stalemate at Fort Detroit, and Pontiac's influence among his followers began to wane. Groups of Indians began to abandon the siege, some of them making peace with the British before departing. Pontiac lifted the siege on October 31, 1763, convinced that the French would not come to his aid at Detroit, and removed to the Maumee River where he continued his efforts to rally resistance against the British.

Before other British outposts had learned of Pontiac's siege at Detroit, Indians captured five small forts in attacks between May 16 and June 2. Fort Sandusky, a small blockhouse on the Lake Erie shore, was the first to be taken. It had been built in 1761 by order of General Amherst, despite the objections of local Wyandots who warned the commander they would burn it down. On May 16, 1763, a group of Wyandots gained entry under the pretense of holding a council, the same stratagem that had failed in Detroit nine days earlier. They seized the commander and killed 15 soldiers and a number of British traders, among the first of about 100 traders who were killed in the early stages of the war. They ritually scalped the dead and burned the fort to the ground, as the Wyandots had threatened a year earlier.

Potawatomis captured Fort St. Joseph (site of present Niles, Michigan) on May 25, 1763, using the same method as at Sandusky. They seized the commander and killed most of the fifteen-man garrison. Fort Miami (present Fort Wayne, Indiana) was the third fort to fall. On May 27, the fort commander was lured out by his Indian mistress and shot dead by Miamis. The nine-man garrison surrendered after the fort was surrounded.

In the Illinois Country, Weas, Kickapoos, and Mascoutens took Fort Ouiatenon, about 5 miles (8.0km) west of present Lafayette, Indiana, on June 1, 1763. They lured soldiers outside for a council, then took the 20-man garrison captive without bloodshed. These Indians had good relations with the British garrison, but emissaries from Pontiac had convinced them to strike. The warriors apologized to the commander for taking the fort, saying "they were Obliged to do it by the other Nations." In contrast with other forts, the Indians did not kill their captives at Ouiatenon.

The fifth fort to fall, Fort Michilimackinac (present Mackinaw City, Michigan), was the largest fort taken by surprise. On June 4, 1763, Ojibwas staged a game of stickball with visiting Sauks. The soldiers watched the game, as they had done on previous occasions. The Indians hit the ball through the open gate of the fort, then rushed in and seized weapons that Indian women had smuggled into the fort. They killed about 15 of the 35-man garrison in the struggle; they later tortured five more to death.

Three forts in the Ohio Country were taken in a second wave of attacks in mid-June. Senecas took Fort Venango (near present Franklin, Pennsylvania) around June 16, 1763. They killed the entire 12-man garrison, keeping the commander alive to write down the Seneca's grievances, then burned him at the stake. Possibly the same Senecas attacked Fort Le Boeuf (present Waterford, Pennsylvania) on June 18, but most of the 12-man garrison escaped to Fort Pitt.

The eighth and final fort to fall, Fort Presque Isle (present Erie, Pennsylvania), was surrounded by about 250 Ottawas, Ojibwas, Wyandots, and Senecas on June 19. After holding out for two days, the garrison of 30 to 60 men surrendered on the condition that they could return to Fort Pitt. The Indians agreed, but then took the soldiers captive, killing many.

Colonists in western Pennsylvania fled to the safety of Fort Pitt after the outbreak of the war. Nearly 550 people crowded inside, including more than 200 women and children. Simeon Ecuyer, the Swiss-born British officer in command, wrote that "We are so crowded in the fort that I fear disease the smallpox is among us." Delawares and others attacked the fort on June 22, 1763, and kept it under siege throughout July. Meanwhile, Delaware and Shawnee war parties raided into Pennsylvania, taking captives and killing unknown numbers of settlers. Indians sporadically fired on Fort Bedford and Fort Ligonier, smaller strongholds linking Fort Pitt to the east, but they never took them.

Before the war, Amherst had dismissed the possibility that Indians would offer any effective resistance to British rule, but that summer he found the military situation becoming increasingly grim. He wrote the commander at Fort Detroit that captured enemy Indians should "immediately be put to death, their extirpation being the only security for our future safety." To Colonel Henry Bouquet, who was preparing to lead an expedition to relieve Fort Pitt, Amherst wrote on about June 29, 1763: "Could it not be contrived to send the small pox among the disaffected tribes of Indians? We must on this occasion use every stratagem in our power to reduce them."[105] Bouquet responded that he would try to spread smallpox to the Indians by giving them blankets that had been exposed to the disease.[note 4] Amherst replied to Bouquet on July 16, endorsing the plan.[note 5]

As it turned out, officers at Fort Pitt had already attempted what Amherst and Bouquet were discussing, apparently without having been ordered by Amherst or Bouquet.[111][note 6] During a parley at Fort Pitt on June 24, Captain Ecuyer gave representatives of the besieging Delawares two blankets and a handkerchief that had been exposed to smallpox, hoping to spread the disease to the Indians and end the siege.[114] William Trent, the fort's militia commander, wrote in his journal that "we gave them two Blankets and an Handkerchief out of the Small Pox Hospital. I hope it will have the desired effect." Trent submitted an invoice to the British Army, writing that the items had been "taken from people in the Hospital to Convey the Smallpox to the Indians." The expense was approved by Ecuyer, and ultimately by General Thomas Gage, Amherst's successor.

Historian and folklorist Adrienne Mayor (1995) wrote that the smallpox blanket incident "has taken on legendary overtones as believers and nonbelievers continue to argue over the facts and their interpretation." Peckham (1947), Jennings (1988), and Nester (2000) concluded the attempt to deliberately infect Indians with smallpox was successful, resulting in numerous deaths that hampered the Indian war effort. Fenn (2000) argued that "circumstantial evidence" suggests the attempt was successful.

Other scholars have expressed doubts about whether the attempt was effective. McConnell (1992) argued the smallpox outbreak among the Indians preceded the blanket incident, with limited effect, since Indians were familiar with the disease and adept at isolating the infected. Ranlet (2000) wrote that previous historians had overlooked that the Delaware chiefs who handled the blankets were in good health a month later; he believed the attempt to infect the Indians had been a "total failure."[note 7] Dixon (2005) argued that if the scheme had been successful, the Indians would have broken off the siege of Fort Pitt, but they kept it up for weeks after receiving the blankets. Medical writers have expressed reservations about the efficacy of spreading smallpox through blankets and the difficulty of determining if the outbreak was intentional or naturally occurring.[note 8]

On August 1, 1763, most of the Indians broke off the siege at Fort Pitt to intercept 500 British troops marching to the fort under Colonel Bouquet. On August 5, these two forces met at the Battle of Bushy Run. Although his force suffered heavy casualties, Bouquet fought off the attack and relieved Fort Pitt on August 20, bringing the siege to an end. His victory at Bushy Run was celebrated by the British; church bells rang through the night in Philadelphia, and King George praised him.

This victory was followed by a costly defeat. Fort Niagara, one of the most important western forts, was not assaulted, but on September 14, 1763, at least 300 Senecas, Ottawas, and Ojibwas attacked a supply train along the Niagara Falls portage. Two companies sent from Fort Niagara to rescue the supply train were also defeated. More than 70 soldiers and teamsters were killed in these actions, which colonists dubbed the "Devil's Hole Massacre," the deadliest engagement for British soldiers during the war.

The violence and terror of Pontiac's War convinced many western Pennsylvanians that their government was not doing enough to protect them. This discontentment was manifested most seriously in an uprising led by a vigilante group known as the Paxton Boys, so-called because they were primarily from the area around the Pennsylvania village of Paxton (or Paxtang). The Paxtonians turned their anger towards American Indiansmany of them Christianswho lived peacefully in small enclaves in the midst of white Pennsylvania settlements. Prompted by rumors that an Indian war party had been seen at the Indian village of Conestoga, on December 14, 1763, a group of more than 50 Paxton Boys marched on the village and murdered the six Susquehannocks they found there. Pennsylvania officials placed the remaining 14 Susquehannocks in protective custody in Lancaster, but on December 27, the Paxton Boys broke into the jail and killed them. Governor John Penn issued bounties for the arrest of the murderers, but no one came forward to identify them.

The Paxton Boys then set their sights on other Indians living within eastern Pennsylvania, many of whom fled to Philadelphia for protection. Several hundred Paxtonians marched on Philadelphia in January 1764, where the presence of British troops and Philadelphia militia prevented them from committing more violence. Benjamin Franklin, who had helped organize the militia, negotiated with the Paxton leaders and brought an end to the crisis. Afterwards, Franklin published a scathing indictment of the Paxton Boys. "If an Indian injures me," he asked, "does it follow that I may revenge that Injury on all Indians?"

Indian raids on frontier settlements escalated in the spring and summer of 1764. The hardest hit colony was Virginia, where more than 100 settlers were killed. On May 26 in Maryland, 15 colonists working in a field near Fort Cumberland were killed. On June 14, about 13 settlers near Fort Loudoun in Pennsylvania were killed and their homes burned. The most notorious raid occurred on July 26, when four Delaware warriors killed and scalped a school teacher and ten children in what is now Franklin County, Pennsylvania. Incidents such as these prompted the Pennsylvania Assembly, with the approval of Governor Penn, to reintroduce the scalp bounties offered during the French and Indian War, which paid money for every enemy Indian killed above the age of ten, including women.

General Amherst, held responsible for the uprising by the Board of Trade, was recalled to London in August 1763 and replaced by Major General Thomas Gage. In 1764, Gage sent two expeditions into the west to crush the rebellion, rescue British prisoners, and arrest the Indians responsible for the war. According to historian Fred Anderson, Gage's campaign, which had been designed by Amherst, prolonged the war for more than a year because it focused on punishing the Indians rather than ending the war. Gage's one significant departure from Amherst's plan was to allow William Johnson to conduct a peace treaty at Niagara, giving Indians an opportunity to "bury the hatchet."[138]

From July to August 1764, Johnson conducted a treaty at Fort Niagara with about 2,000 Indians in attendance, primarily Iroquois. Although most Iroquois had stayed out of the war, Senecas from the Genesee River valley had taken up arms against the British, and Johnson worked to bring them back into the Covenant Chain alliance. As restitution for the Devil's Hole ambush, the Senecas were compelled to cede the strategically important Niagara portage to the British. Johnson even convinced the Iroquois to send a war party against the Ohio Indians. This Iroquois expedition captured a number of Delawares and destroyed abandoned Delaware and Shawnee towns in the Susquehanna Valley, but otherwise the Iroquois did not contribute to the war effort as much as Johnson had desired.

Having secured the area around Fort Niagara, the British launched two military expeditions into the west. The first expedition, led by Colonel John Bradstreet, was to travel by boat across Lake Erie and reinforce Detroit. Bradstreet was to subdue the Indians around Detroit before marching south into the Ohio Country. The second expedition, commanded by Colonel Bouquet, was to march west from Fort Pitt and form a second front in the Ohio Country.

Bradstreet left Fort Schlosser in early August 1764 with about 1,200 soldiers and a large contingent of Indian allies enlisted by Sir William Johnson. Bradstreet felt that he did not have enough troops to subdue enemy Indians by force, and so when strong winds on Lake Erie forced him to stop at Fort Presque Isle on August 12, he decided to negotiate a treaty with a delegation of Ohio Indians led by Guyasuta. Bradstreet exceeded his authority by conducting a peace treaty rather than a simple truce, and by agreeing to halt Bouquet's expedition, which had not yet left Fort Pitt. Gage, Johnson, and Bouquet were outraged when they learned what Bradstreet had done. Gage rejected the treaty, believing that Bradstreet had been duped into abandoning his offensive in the Ohio Country. Gage may have been correct: the Ohio Indians did not return prisoners as promised in a second meeting with Bradstreet in September, and some Shawnees were trying to enlist French aid in order to continue the war.

Bradstreet continued westward, unaware his unauthorized diplomacy was angering his superiors. He reached Fort Detroit on August 26, where he negotiated another treaty. In an attempt to discredit Pontiac, who was not present, Bradstreet chopped up a peace belt Pontiac had sent to the meeting. According to historian Richard White, "such an act, roughly equivalent to a European ambassador's urinating on a proposed treaty, had shocked and offended the gathered Indians." Bradstreet also claimed the Indians had accepted British sovereignty as a result of his negotiations, but Johnson believed this had not been fully explained to the Indians and that further councils would be needed. Bradstreet had successfully reinforced and reoccupied British forts in the region, but his diplomacy proved to be controversial and inconclusive.

Colonel Bouquet, delayed in Pennsylvania while mustering the militia, finally set out from Fort Pitt on October 3, 1764, with 1,150 men. He marched to the Muskingum River in the Ohio Country, within striking distance of a number of Indian villages. Treaties had been negotiated at Fort Niagara and Fort Detroit, so the Ohio Indians were isolated and, with some exceptions, ready to make peace. In a council which began on October 17, Bouquet demanded that the Ohio Indians return all captives, including those not yet returned from the French and Indian War. Guyasuta and other leaders reluctantly handed over more than 200 captives, many of whom had been adopted into Indian families. Not all of the captives were present, so the Indians were compelled to surrender hostages as a guarantee that the other captives would be returned. The Ohio Indians agreed to attend a more formal peace conference with William Johnson, which was finalized in July 1765.

Although the military conflict essentially ended with the 1764 expeditions, Indians still called for resistance in the Illinois Country, where British troops had yet to take possession of Fort de Chartres from the French. A Shawnee war chief named Charlot Kask emerged as the most strident anti-British leader in the region, temporarily surpassing Pontiac in influence. Kask traveled as far south as New Orleans in an effort to enlist French aid against the British.

In 1765, the British decided that the occupation of the Illinois Country could only be accomplished by diplomatic means. As Gage commented to one of his officers, he was determined to have "none our enemy" among the Indian peoples, and that included Pontiac, to whom he now sent a wampum belt suggesting peace talks. Pontiac had become less militant after hearing of Bouquet's truce with the Ohio country Indians. Johnson's deputy, George Croghan, accordingly traveled to the Illinois country in the summer of 1765, and although he was injured along the way in an attack by Kickapoos and Mascoutens, he managed to meet and negotiate with Pontiac. While Charlot Kask wanted to burn Croghan at the stake, Pontiac urged moderation and agreed to travel to New York, where he made a formal treaty with William Johnson at Fort Ontario on July 25, 1766. It was hardly a surrender: no lands were ceded, no prisoners returned, and no hostages were taken. Rather than accept British sovereignty, Kask left British territory by crossing the Mississippi River with other French and Native refugees.

The total loss of life resulting from Pontiac's War is unknown. About 400 British soldiers were killed in action and perhaps 50 were captured and tortured to death. George Croghan estimated that 2,000 settlers had been killed or captured, a figure sometimes repeated as 2,000 settlers killed.[note 9] [note 10] The violence compelled approximately 4,000 settlers from Pennsylvania and Virginia to flee their homes. American Indian losses went mostly unrecorded, but it has been estimated at least 200 warriors were killed in battle, with additional deaths of germ warfare initiated at Fort Pitt was successful.

Pontiac's War has traditionally been portrayed as a defeat for the Indians, but scholars now usually view it as a military stalemate: while the Indians had failed to drive away the British, the British were unable to conquer the Indians. Negotiation and accommodation, rather than success on the battlefield, ultimately brought an end to the war. The Indians had won a victory of sorts by compelling the British government to abandon Amherst's policies and create a relationship with the Indians modeled on the Franco-Indian alliance.

Relations between British colonists and American Indians, which had been severely strained during the French and Indian War, reached a new low during Pontiac's War. According to Dixon (2005), "Pontiac's War was unprecedented for its awful violence, as both sides seemed intoxicated with genocidal fanaticism." Richter (2001) characterizes the Indian attempt to drive out the British, and the effort of the Paxton Boys to eliminate Indians from their midst, as parallel examples of ethnic cleansing. People on both sides of the conflict had come to the conclusion that colonists and natives were inherently different and could not live with each other. According to Richter, the war saw the emergence of "the novel idea that all Native people were 'Indians,' that all Euro-Americans were 'Whites,' and that all on one side must unite to destroy the other."

The British government also came to the conclusion that colonists and Indians must be kept apart. On October 7, 1763, the Crown issued the Royal Proclamation of 1763, an effort to reorganize British North America after the Treaty of Paris. The Proclamation, already in the works when Pontiac's War erupted, was hurriedly issued after news of the uprising reached London. Officials drew a boundary line between the British colonies and American Indian lands west of the Appalachian Mountains, creating a vast "Indian Reserve" that stretched from the Appalachians to the Mississippi River and from Florida to Quebec. By forbidding colonists from trespassing on Indian lands, the British government hoped to avoid more conflicts like Pontiac's War. "The Royal Proclamation," writes Calloway (2006), "reflected the notion that segregation not interaction should characterize Indian-white relations."

The effects of Pontiac's War were long-lasting. Because the Proclamation officially recognized that indigenous people had certain rights to the lands they occupied, it has been called a Native American "Bill of Rights," and still informs the relationship between the Canadian government and First Nations. For British colonists and land speculators, however, the Proclamation seemed to deny them the fruits of victorywestern landsthat had been won in the war with France. This created resentment, undermining colonial attachment to the Empire and contributing to the coming of the American Revolution. According to Calloway, "Pontiac's Revolt was not the last American war for independenceAmerican colonists launched a rather more successful effort a dozen years later, prompted in part by the measures the British government took to try to prevent another war like Pontiac's."

For American Indians, Pontiac's War demonstrated the possibilities of pan-tribal cooperation in resisting Anglo-American colonial expansion. Although the conflict divided tribes and villages, the war also saw the first extensive multi-tribal resistance to European colonization in North America, and the first war between Europeans and American Indians that did not end in complete defeat for the Indians. The Proclamation of 1763 ultimately did not prevent British colonists and land speculators from expanding westward, and so Indians found it necessary to form new resistance movements. Beginning with conferences hosted by Shawnees in 1767, in the following decades leaders such as Joseph Brant, Alexander McGillivray, Blue Jacket, and Tecumseh would attempt to forge confederacies that would revive the resistance efforts of Pontiac's War.

Originally posted here:

Pontiac's War - Wikipedia