Daily Archives: September 17, 2021

Macau’s casinos could be the next target in China’s crackdown – Quartz

Posted: September 17, 2021 at 9:09 pm

In its 22 years under Chinese rule, Macau evolved from a sleepy and slightly sleazy Portuguese colony to the biggest gambling jurisdiction in the world. Fueled by foreign investment, laissez-faire oversight, and billions of gamblers a short flight away, casino revenue on the island reached a high of 363 billion pacatas, or $45.4 billion, in 2013, compared to $10.3 billion in Las Vegas.

Recent signals from Beijing, however, suggest the party may be over.

Lei Wai Nong, Macaus secretary for economy and finance, announced yesterday (Sept. 14) the government would begin reviewing the casino industry, with an eye toward tightening oversight in areas such as licensing, employee welfare, and daily supervision. This follows proposals to increase the number of casino inspectors from 192 to 459, and previous efforts to regulate illegal lending and cash transfers related to gambling.

The prospect of tighter controls over the industry come as casino operators prepare to rebid next year for the licenses necessary to operate in Macau. The new scrutiny opens up the possibility that companies found wanting could lose the right to offer gambling, and with it, their billion dollar investments. Investors, fearing the worse, this week dumped shares of casino companies with Macau properties like MGM China and Wynn Macau in record volumes, costing the industry $18 billion of market value. Analysts quickly downgraded the casino operators.

Over the past several months, China has been cracking down on perceived social vices and financial excesses of all sorts. On Aug. 17, Chinese president Xi Jinping took aim at the nations super rich, calling for common prosperity for all and leading to pledges from communist party officials to carry out reasonable adjustments. Soon after, the government placed restrictions on video games, which a state media outlet referred to as spiritual opium, restricting the days and hours they could be played by children under 18. Sectors ranging from technology to for-profit education have also fallen under Chinas crosshairs.

Casinos, palaces of capitalistic decadence, might seem ripe for draconian measures. But Beijing may also fear the potential flight of foreign investors.

Gambling has been a major industry in Macau since the 19th century, and starting in 1962, was largely run as a licensed monopoly by Stanley Ho and his company, Sociedade de Jogos de Macau. Then under Portuguese control, Macau had a reputation for lawlessness and corruption, which boiled over in 1997 as a gang war broke out among the Triads, organized crime syndicates, resulting in dozens of deaths. After control of the island passed from Portugal to China in 1999, authorities clamped down on crime and broke up Hos monopoly in 2002, opening the island to outside investors as well as mainland tourists.

Casino operators from the US, Malaysia, and Australia leapt at the chance to tap the worlds biggest gambling market. In 2007, Las Vegas Sands, the company controlled by latebillionaire Sheldon Adelson, opened the Venetian Macau, at the time the worlds largest casino. Other companies followed, and Macau soon surpassed Las Vegas as the worlds gambling capital. By 2020, there were 41 casino in Macau, supplying 80% of its tax revenue and three quarters of its jobs.

A 2014 crackdown on corruption and illegal money transfers led to a decline in gambling revenue, but Macau has largely been a success story for Beijing, enjoying unprecedented prosperity and a measure of corporate respectability. Particularly compared to its neighbor, Hong Kong, Macau has not actively resisted Chinese control and has caused few problems.

Significant new restrictions on the casino industry could upend that delicate balance. While a return of Triad gang wars seems unlikely, Beijing may be loathe to invite instability back to the region.

Original post:

Macau's casinos could be the next target in China's crackdown - Quartz

Posted in Casino | Comments Off on Macau’s casinos could be the next target in China’s crackdown – Quartz

‘What We Do In the Shadows’ Recap: The Casino – The Workprint

Posted: at 9:09 pm

Nearly 130 miles south of New York City lies what once was the countrys preeminent getaway destination. This Eastern seaboard town had it all: economic boom through tourism, economic boom through corruption and racketeering, economic boom through unenforced prohibition- and that was even before the advent of legalized gambling! Though no longer labeled The Worlds Playground, episode four of What We Do In The Shadows (FX) titled The Casino reminds us that though Las Vegas looms larger and prettier, Dirty Jerseys Atlantic City still remains something more real: The Devils Playground.

Its all aboard! at the Vampire Residence, as the crew is packing their trunks for a vacation. The Guide (Kristen Schaal) seems a bit taken aback by this with the backlog of Vampiric Council matters to be attended to, but its been several decades since last the crew cut loose and let their hair down. However, Shaun (Anthony Atamanuik) and Charmaine (Marissa Janet Winkour), whom you may remember from the Superb-Owl party last season have decided to renew their vows and planned a group getaway, with the whole gang invited! Viva Atlantic City (which, Laszlo tickles on the ivories), leading us into an unorthodox main title, complete with footage of their travel into the nocturnal mecca of sin.

It should be noted, before they leave, they must pack the soil of their coffins, as mere documentation for travel will not suffice. Without the ancestral terra firma, the vampires cannot eat, sleep, leave and their powers wane.

Settling into their hotel rooms, Colin Robinson (Mark Proksch) is already at it snapping Polaroids of banal things, Guillermo (Harvey Guillen) is setting out his cot, Nandor (Kayvan Novak) is attending to his soil while Laszlo (Matt Berry) is plowing his love Nadja (Natasia Demetriou).

At dinner, as the vampires struggle with how to convincingly eat, and the girls are gab about deals on fashion, Shaun proposes a toast to his wife and good friends. All eleven of them. Oh, we know why the nocturnal nabobs were invited group rate! and the number is not lost on Shaunie. Hes a massive Oceans 12 fan, as youll remember from the Superb-Owl episode, but now tearfully respects 11 as a prequel.

He brings the room up by shouting out to Laszlo, Frankie (Gavin Fox) and Mikey, before Mikey passes stone-cold out, causing the rest of the party to think hes plastered before the nights begun. Judging by the craven smile on ones face, we know who the culprit is.

Laszlo summarily commands the erstwhile familiar to fetch a broom from the hostess, as if he still thinks hes a familiar. Even Gizmo himself thinks that the transition to bodyguard status has been non-existent. Nandor does remind them that Guillermo no longer holds such a subservient title, so his inclusion is of import. Colin co-signs, citing that office drones work harder when feeling part of a family, thus neglecting their own families and building a higher threshold for degradation. Upon returning to his seat, the vampires ham-fistedly grill him on his interests, including his love life in order to gain more insight or feign more interest in someone theyve largely seen as a breathing piece of furniture in the house.

Guillermo is coy about divulging, but Laszlo breaks the seal, as is customary, citing the most beautiful thing in the world as fucking. Personally, who could blame the libertine lothario? Before Guillermo could spill the beans on his worldview on that due to his parents, which the vampires are waiting on with bated breath, Shaun interrupts.

It turns out that rascal Frankie put glass in the piccata, so the House comped the group a bunch of chips. With that, the group breaks off to hit the casino, leaving Guillermo all by his lonesome. Their respect is to be earned and it may take more than just saving their lives once to get there.

Charmaine and the girls decide to hit up a Rat Pack revue, which tickles Nadja to no end, thinking they are the OG lounge luminaries she partied with back in ACs heyday. Though she cannot imbibe with the women, Nadja still has a swingin time as if she had, calling out to them and reminding, spread eagle what they might have forgotten over the years.

At the tables, Colin is getting his crunk on, boring his competitors and the dealer with palaver about the Monaco Grand Monday nights fight of Jackson vs. Rodriguez.

Elsewhere, Nandors livin it up with his newfound love and no, it aint Guillermo. Its the Big Bang Theory slots. Hes more animated than Guillermos ever seen him, especially when hitting it big, causing him to shout Bazinga! (which is the war cry of Sheldon.)

While an overzealous Nadja takes the girls backstage at the Rat Pack revue, freaking out the trio (that bear zero passing resemblance to the originals), Colins all but drained the last of his little island of gamblers. Nandor is riding high on this new addiction, but the sun is coming up and they all must retire.

Theres only one problem- nobody can slumber. At hand lies the even bigger cause- their ancestral soil is gone all because of Colin. His favorite show (the in-house Monaco Grand commercial) he was caught up in binge-watching had him neglect noticing housekeeping doing what they do best. The vampires can already feel their powers wax and wane, as Laszlo goes from bat form to sparrow form, which is not only adorable but also a clever answer to a question I never had.

This prompts Nandor to send Guillermo on a journey and Nadja sending her beloved to ask his bestie, Shaun into lending him his credit card for the mission with no questions asked, since his power of persuasion is kaput. Laszlo proceeds with trepidation, as he doesnt want to jeopardize the only real human friendship he has on this blue spinning marble. Surprisingly, Shaun feels the love and lends him the credit card, on the sole proviso of being paid back ASAP, as the Commemorative Patrick Ewing Discover Card is an emergency only piece of plastic and with that, Guillermo heads to Europe!

At the Vow Renewal Ceremony, Nadja, Laszlo, and Nandor are fading and fast. This is a limbo from which they may never return. Colins still fine, still snapping photos, such as when Nadja succumbs to her soupy brain and falls down. In fact, what seems like weeks to the vampires only is 14 hours to Colin.

From the bustling Heathrow International to the majestic Paralia Urika Beach in Antipaxos to the precarious South Iranian Border (formerly Al Qolnidar), Guillermo shows why he not only protec, he attac but most importantly, he bringin dat shit bac.

Back in the rooms, as Nandor enjoys Chuck Lorres splooge on TV, Laszlos having a moment, guilt-ridden over the $7500 hes taken. By virtue of being a true gent, he goes down to explain himself. This only pours more salt on the wound when he learns that Shaun used to have a big-time gambling problem, with his second vow renewal this trip to not romance those demons.

Well, there are three absolutes in this world of chance you can set a watch to odds are lucky for a reason, never bet on the Knickerbockers, and that there are no absolutes.

This comes as a huge blow to Laszlo, but his dear Nadja attempts to remedy the situation by using her feminine wiles with her old pals, the Rat Pack and when that fails, she uses her next best non-vampiric asset: threats. Though she does fall flat, quite literally, she does succeed in collecting, as sometimes pity is more useful than power.

This is basically all for naught, however, as the amassed wealth is a mere 300 clams. Hubby isnt quite sure they were the hepcats she used to hang with, but Nadja wants none of that heresy.

Nandor listlessly bops away at his favorite slot, but not even Colin pointing out that he got a couple of Koothrapalis, a Hofstader, four Wolowitzes, and a Penny could prepare Nandor for getting him noodle baked about what the Big Bang Theory actually means.

They map out on opposite walls of the room in marker their views on the creation of the world, Colins being heliocentric and Nandors being one hes believed for seven and a half centuries: that the world rests on four elephants that reside on the back of a gigantic turtle. Hes been converted, due to science and logic trouncing fantasy and whim and even more depressed due to the fact that were but a spec of cosmic dust in the grand scheme of things.

A contemplative Nandor sits atop the Monaco Grand Hotel and Casino, feeling lonely as ever, even as Guillermo is soaring right above him with a little piece of home in hand.

Upon arrival, Guillermos greeted to a room of emotional and mental anguish across the board- Laszlos regret of possibly causing his best mortal friend financial and marital ruination, Nadjas rumination of the Rat Packs fall from grace, Nandors existentialist crisis, and Colins castrated viewing of his favorite tv show with the volume off.

Its time for Guillermo de la Cruz to put Frank Farmer to shame, first by getting everybody to night-nights and pumping up the volume on Colins show as he works on his plan on how to get them out of the jam.

Once they are bright-eyed and bushy-tailed, as evidenced by their inherent treatment of him, Guillermo lays out the scheme with some Danny Ocean panache. At 6.47 pm, hell head to the box office to get the tickets to the fight. At 6.52 pm in the elevator, Nandor is to meet one of the boxers, Eli Jackson to hypnotize him. At 6.55 pm, Laszlo is to hypnotize the other, Arturio Rodriguez. At 6.59 pm, Colin Robinson is to place a nice, simple bet. At 8.00 pm, they all take their seats at the fight and, well, Ring-A-Ding-Ding

Ten seconds into round six, Nadja triggers the hypnosis of both pugilists by yelling out Aint That A Kick In The Head causing a knockout that can only be likened to when one successfully pops the cork off a bottle of champagne.

Colin collects the cash, they all experience a flying on earth known as the escalator, hand over the winnings to a thankful Shaun who swears off gambling (before betting it all on 12 as they walk away) and head back into the party bus for, but not before giving Guillermo a welcome to the family card of sorts.

Like Loading...

Read the original here:

'What We Do In the Shadows' Recap: The Casino - The Workprint

Posted in Casino | Comments Off on ‘What We Do In the Shadows’ Recap: The Casino – The Workprint

Walker’s Bluff Hopes to Move Forward Soon with Permanent Casino Facility – WSIU

Posted: at 9:09 pm

We've learned more details about the Illinois Gaming Board's action last week in regards to the casino license sought by Walker's Bluff.

The gaming board's director of policy Joe Miller says members did not license Walkers Bluff at their meeting on September 9.

Rather, the Board approved a request from Walkers Bluff to amend its application to forgo operation of a temporary facility.

On September 3, the Williamson County Board approved an amendment to the economic development plan for Walkers Bluff, which now plans to move directly to construction of its permanent casino facility instead of operating a temporary casino as it initially intended to do while the permanent casino is under construction.

During the gaming board meeting, Walkers Bluff said the need for local infrastructure and road improvements drove this decision.

Walkers Bluff expects to seek approval from the Illinois Gaming Board to commence construction sometime in October with the estimated construction to last around 18 months.

Go here to see the original:

Walker's Bluff Hopes to Move Forward Soon with Permanent Casino Facility - WSIU

Posted in Casino | Comments Off on Walker’s Bluff Hopes to Move Forward Soon with Permanent Casino Facility – WSIU

Ohio casinos, racinos smash August record with $194 million in gambling revenue – cleveland.com

Posted: at 9:09 pm

CLEVELAND, Ohio - Ohios casino and racino industry set another monthly record, taking in $194.3 million in gambling revenue in August after paying out winnings, reports from the states casino control and lottery commissions show.

The revenue for the 11 facilities topped the previous August record of $172.1 million, set a year ago, with a gain of 12.9%. Ahead of the pandemic, the August record had been $164.4 million, set in 2019.

But despite the August record, business slowed the last full month of the summer. Monthly revenue records were also set in July ($211.2 million) and June ($196.8 million).

Through the first eight months of 2021, gambling revenue has totaled nearly $1.6 billion statewide. About a third of this money is turned over to the state in the form of taxes and fees.

In the Cleveland/Akron market last month:

* MGM Northfield Park had revenue of $23.3 million, up 20.8% from $19.3 million in August 2020.

* JACK Cleveland Casino had revenue of $21.9 million, up 20.2% from $18.2 million.

* JACK Thistledown Racino had revenue of $17 million, up 20.8% from $14.1 million.

Ohios four casinos are permitted to run table games, poker rooms and slot machines under the regulation of the Ohio Casino Control Commission. The seven racinos come under the regulation of the Ohio Lottery Commission, and are not permitted to offer only skilled-based, instead using slots-like machines known as video lottery terminals.

Previously

Best bets to make your entertainment dollars last longer at the casino - Thats Rich!

See inside JACK Thistledown Racinos new, climate-controlled outdoor gaming patio

JACK announces hiring events for Cleveland casino and Thistledown racino

More:

Ohio casinos, racinos smash August record with $194 million in gambling revenue - cleveland.com

Posted in Casino | Comments Off on Ohio casinos, racinos smash August record with $194 million in gambling revenue – cleveland.com

Judge denies admission of evidence allegedly connecting Kyle Rittenhouse to Proud Boys – News-Daily.com

Posted: at 9:07 pm

A judge in Wisconsin sided with defense attorneys Friday and denied motions filed by prosecutors seeking to admit evidence at trial showing Kyle Rittenhouse's involvement in a previous fight and his alleged association with the Proud Boys.

Among their multiple motions filed, prosecutors were hoping to admit evidence Rittenhouse had an association with the Proud Boys, a group linked to political violence.

In January, Rittenhouse pleaded not guilty to two felony charges of homicide in the deaths of Anthony Huber and Joseph Rosenbaum, and felony attempted homicide for wounding Gaige Grosskreutz during protests in August 2020, following the police shooting of Jacob Blake.

Specifically, in regard to January 2021, months after the Kenosha shooting, when Rittenhouse went to a local bar with his mother about 90 minutes after his arraignment, Rittenhouse posed for pictures with individuals seen flashing the 'OK' sign, which prosecutors say has been co-opted as a sign of 'white power' by known white supremacist groups.

According to prosecutors, they have since learned some of the people he posed with were in the "highest echelons" of the Wisconsin chapter of the Proud Boys.

Defense attorney Corey Chirafisi said, "There's no information Mr. Rittenhouse knew who they were."

"For this to be considered by you (Judge Schroeder), there must be evidence... that on August 25th, 2020 Kyle Rittenhouse was either a member of the Proud Boys or had loyalties to that group," said Chirafisi, who added there was no evidence of that.

Kenosha County Judge Schroeder agreed with the defense, "For me to let that in as evidence for a motive that existed four months earlier? Can't see it."

On the January 2021 Rittenhouse bar appearance, Schroeder ruled, "There's still no suggestion in the evidence ... that this was anything other than a happenstance occurrence."

A separate motion involved recently discovered video, taken two weeks before the Kenosha shooting, which showed Rittenhouse talking about an AR rifle and wanting to shoot people he allegedly thought were looting a CVS store.

Prosecutors said the video shows that he "eagerly made assumptions about the intentions of others even though he knew absolutely nothing about what was going on. The video also demonstrates that the defendant fervently sought to insert himself as an armed vigilante into situations that had nothing to do with him," court documents allege.

Chirafisi argued Rittenhouse could have inserted himself but didn't, "He never made contact with those people at CVS. He doesn't even step from the vehicle to verbally confront them in any way. He doesn't do anything."

Schroeder said, "The events are so totally dissimilar," and that for now, "I'm going to withhold a final decision with a bias toward refusing."

As part of a third motion filed, prosecutors were hoping to admit a June 2020 incident, when they say Rittenhouse was involved in a physical altercation that began between his sister and someone else.

"The defendant is essentially a teenage vigilante, involving himself in things that don't concern him," said Binger during the motions hearing Friday. "It shows that his understanding of self-defense ... is a certain way."

Chirafisi argued the fight "adds nothing to that determination as to whether or not his actions were or were not in self-defense ... as it relates to his state of mind two and a half months later."

Schroeder agreed in his ruling, "I don't see any connection here at all so that request is denied." The judge added he was "virtually certain" if he had admitted it, it would end up in a reversal if Rittenhouse was convicted.

Rittenhouse appeared in person to the motions hearing Friday in a suit and tie alongside his attorneys.

Jury selection in the Rittenhouse trial is expected to begin November 1, for which both prosecutors and defense attorneys affirmed Friday they will be ready.

Schroeder deferred his decision to a later date in determining whether juror questionnaires will be sent out before jury selection.

The-CNN-Wire

& 2021 Cable News Network, Inc., a WarnerMedia Company. All rights reserved.

ABBA sent shockwaves of excitement across the world when they announced their reunion after 40 years apart. Click for more.

Read the original post:

Judge denies admission of evidence allegedly connecting Kyle Rittenhouse to Proud Boys - News-Daily.com

Posted in Proud Boys | Comments Off on Judge denies admission of evidence allegedly connecting Kyle Rittenhouse to Proud Boys – News-Daily.com

What Do Psoriasis, Eczema, and Erectile Dysfunction Have in Common? – Californianewstimes.com

Posted: at 9:06 pm

Have you ever thought these three health conditions can have something in common? It turns out that they do. Even more. Every health condition shares some similarities with a very different one for one apparent reason: they all come from within. Everything that one human can experience has to do with her psychological and physiological health simultaneously. As the body works as a synchronized mechanism, one issue can bring about different conditions.

Want to learn what these three share?

Well, you know the answer already.

The Driver Inside

These three conditions are all connected to the inner driver the blood. You may call it a transport or driver as blood delivers significant nutrients and oxygen and takes all the unnecessary elements and chemicals from all the cells. Your mind communicates with the body through sending hormones. If the brain is the sender, hormones are the package, and organs are the receiver, then blood is the courier. When something goes wrong with it, conditions ranging from skin issues to sexual disorders can arise.

Psoriasis: Attacking Yourself

Psoriasis is responsible for the uncontrolled growth of skin cells as the body itself attacks them. Blood is involved in this process through its cells called white blood cells (also known as T cells). A typical body would make its immune system produce such cells to attack hazardous elements and chemicals penetrating the body.

When a person has psoriasis, those white cells mistake skin cells for some threat. Subsequently, they attack those cells, and the skin has to replenish the attacked ones quickly. It starts producing new cells, which pile up as they appear on the skins surface. This becomes a vicious cycle, and doctors are still not sure about the exact causes of it. One thing is clear: blood is an accomplice here.

Eczema: Itchy and Dry

Broadly speaking, eczema or dermatitis is about skin inflammation. If a person has this condition, her skin starts itching and aching, becomes red and dry. Eczema can showcase itself starting from childhood, but adults are not free from it as well. Doctors are not sure about what causes eczema as well. However, blood has its say in the process too.

For example, there is an eczema type called stasis dermatitis, which usually attacks adults. It develops as a result of poor blood circulation and mainly affects the legs. Blood pressure increases, which makes water build up in the capillaries. This brings out the inflammation mentioned above.

If you think you might have such issues, calling for home blood draw services would help you get safely tested and timely prevent or learn about what goes on in your body.

Erectile Dysfunction: You Want, But You Cant

Erectile dysfunction (ED) also has to do with blood flow and circulation. As the name suggests, this condition affects mens ability to develop and maintain a firm erection. While an average man would experience this from time to time, a person with ED would often face this issue. As a result, his self-esteem and sexual performance would suffer.

One can develop ED when the penile muscles or the penis itself do not get enough blood, or the blood vessels are clogged. While getting erect, the penis needs blood support, which is directed by the brain to flow to this area. If there is a plaque on its way or any other issues hindering its circulation, the penis will not get the necessary foundation to develop an erection.

These three represent just a small number of conditions that you may stumble upon due to bloody issues. Blood is the natural transmitter, so regularly testing it would help you keep your health in check.

View original post here:
What Do Psoriasis, Eczema, and Erectile Dysfunction Have in Common? - Californianewstimes.com

Posted in Psoriasis | Comments Off on What Do Psoriasis, Eczema, and Erectile Dysfunction Have in Common? – Californianewstimes.com

New cell type in human skin discovered to contribute to inflammatory skin diseases like atopic dermatitis and psoriasis – EurekAlert

Posted: at 9:06 pm

image:Immunofluorescence labeling of healthy and psoriatic patient skin. Dotted line shows the dermalepidermal junction. HLA-DR: green, GLUT3 (SLC2A3): red, and DAPI: blue. Scale bar = 100 m (low magnification) and 10 m (high magnification). view more

Credit: Please credit image to A*STAR Singapore Immunology Network (SIgN) and Skin Research Institute of Singapore (SRIS).

A team of international scientists and clinical experts have unravelled a new cell type in human skin that contributes to inflammatory skin diseases such as atopic dermatitis (AD) and psoriasis (PSO). Their study findings were published in the Journal of Experimental Medicine in September 2021. The team hails from A*STARs Singapore Immunology Network (SIgN), in collaboration with the Skin Research Institute of Singapore (SRIS), Singapores National Skin Centre, Department of Dermatology, Kyoto University Graduate School of Medicine, Japan, and industry partner Galderma.

Chronic inflammatory skin diseases such as AD and PSO are characterised by the presence of an activated T cell subtypes secreting pro-inflammatory cytokines in the skin. This T cellmediated immune dysregulation is central to the pathogenesis of a wide range of inflammatory skin diseases. Thus, understanding the factors modulating T cell priming and activation in healthy and diseased skin is key to developing effective treatments for these diseases.

Recently, single-cell RNA sequencing (RNA-seq) approach has been used to analyse immune cells in human skin including dendritic cells (DCs) and macrophages, which are cell populations controlling T cell activation. To address the role of DCs and macrophages in chronic inflammatory skin diseases, the team used a combination of complex approaches (single-cell flow cytometry and RNA-seq of index-sorted cells from healthy and diseased human skin) to generate an unbiased profile/ landscape of DCs and macrophages, and to describe their distinct molecular signatures and proportions in skin lesions of AD and PSO patients.

This uncovered a significant enrichment in the proportion of CD14+ DC3s in PSO lesional skin, where they were one of the major cell types co-expressing IL1B and IL23A, two cytokines essential for PSO pathogenesis. This finding suggests that targeting CD14+ DC3 might represent a novel therapeutic option in the treatment of PSO, and demonstrates the potential for the single-cell myeloid cell landscape database to provide important insights into skin biology in health and disease.

Dr Florent Ginhoux, Senior Principal Investigator, SIgN and last author of the study said, The findings from this study are significant as it will allow the design of new strategies to target or modulate myeloid cell populations for better health outcomes for patients of atopic dermatitis and psoriasis.

The roles of antigen-presenting cells in the development of inflammatory skin diseases remain unclear. This study clearly revealed the functions of each antigen-presenting cell subset, which is very informative and valuable to understand the pathogenesis of atopic dermatitis and psoriasis. We expect that this study will lead to the design of new treatment for refractory inflammatory skin diseases. said Prof Kenji Kabashima, Adjunct Principal Investigator from SIgN and SRIS.

More information on the study, Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis can be found from the teams published paper in the Journal of Experimental Medicine: https://pubmed.ncbi.nlm.nih.gov/34279540/

About the Agency for Science, Technology and Research (A*STAR)

The Agency for Science, Technology and Research (A*STAR) is Singapore's lead public sector R&D agency. Through open innovation, we collaborate with our partners in both the public and private sectors to benefit the economy and society. As a Science and Technology Organisation, A*STAR bridges the gap between academia and industry. Our research creates economic growth and jobs for Singapore, and enhances lives by improving societal outcomes in healthcare, urban living, and sustainability. A*STAR plays a key role in nurturing scientific talent and leaders for the wider research community and industry. A*STARs R&D activities span biomedical sciences to physical sciences and engineering, with research entities primarily located in Biopolis and Fusionopolis. For ongoing news, visit http://www.a-star.edu.sg.

Follow us on

Facebook | LinkedIn | Instagram | YouTube

Journal of Experimental Medicine

Experimental study

Cells

Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

Read the original post:
New cell type in human skin discovered to contribute to inflammatory skin diseases like atopic dermatitis and psoriasis - EurekAlert

Posted in Psoriasis | Comments Off on New cell type in human skin discovered to contribute to inflammatory skin diseases like atopic dermatitis and psoriasis – EurekAlert

Roundup: Adalimumab Biosimilar Advancements and a Biosimilar Pill – The Center for Biosimilars

Posted: at 9:06 pm

Alvotech of Reykjavik said it has received a recommendation for approval of its adalimumab biosimilar (AVT02) from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency.

The approval concerns a high-concentration, citrate-free 100-mg/mL formulation of adalimumab, referencing Humira. The positive opinion from the CHMP will go to the European Commission, which is the authority that has the power to authorize marketing of the drug in the European Union and EU member states (Iceland, Liechtenstein, and Norway).

Adalimumab inhibits the activity of tumor necrosis factor, a protein in the body that causes inflammation. The drug is used in the treatment of multiple conditions, including Crohn disease, rheumatoid arthritis, and psoriatic arthritis.

Alvotech noted that Humira has annual sales of about $20 billion. AbbVie, the owner of the Humira franchise, has captured significant market share with its own high-concentration, citrate-free formulation, and Alvotechs product has the potential to take a portion of that business away from the drug company giant.

However, Alvotech would not be the first company to bring a high-concentration biosimilar of adalimumab to market in the European Union. Celltrion Healthcare achieved that milestone in February 2021 when it received European Commission approval to market Yuflyma, a 100-mg formulation.

Both Celltrion and Alvotech hope to gain FDA approval to market their high-concentration adalimumab biosimilars in the United States.

Biosimilar Adalimumab in New Zealand

New Zealands Pharmaceutical Management Agency (Pharmac), the government entity that decides which medicines are subsidized for use in hospitals and community settings, said it is contemplating making the adalimumab biosimilar Amgevita the principal adalimumab product in that country, displacing Humira, in February 2022.

Pharmac said the proposed change would save money. The list price of Amgevita would be lower than the current adalimumab list price, Pharmac said.

Amgevita is available in citrate-free formulation, which reduces pain on injection, and is dispensed in prefilled pens and syringes in doses of 20 mg/0.4 mL and 40 mg/0.8 mL; however, Pharmac said dosing restrictions would be removed for patients using Amgevita.

Higher concentration Humira is available, also in citrate-free formulations, and it was not explained whether the removal of dosing restrictions on Amgevita is intended to compensate for that. A public comment period on the proposal closes on September 22, 2021.

Patients who start on adalimumab treatment would automatically receive Amgevita, and those who are currently treated with Humira would have to switch to Amgevita by September 1, 2022. The Amgevita preference would continue at least through June 2026.

This proposal results from a competitive process for the principal supply of funded adalimumab. It would release significant funds for Pharmac to invest in other medicines for the benefit of New Zealanders, the government organization said.

Theres a (Biosimilar) Pill for That

BioFactura, a Maryland-based biopharmaceutical company, said it will partner with Rani Therapeutics to package its proposed ustekinumab biosimilar (BFI-751) in the form of a robotic pill that is ingested and delivers a drug payload into the small intestine via injection.

The ustekinumab biosimilar candidate would reference Stelara and be used in the treatment of Crohn disease, ulcerative colitis, plaque psoriasis, and psoriatic arthritis. Ustekinumab reduces inflammation that causes these conditions.

The robotic pill concept, if successful, would substitute for subcutaneous or intravenous administration, BioFactura said. The RaniPill capsule is designed to be a pain-free alternative for delivering large molecule chronic disease treatments that are typically administered via injection, the company said.

Rani Therapeutics will conduct preclinical studies to determine whether pill administration is suitable for ustekinumab administration.

BioFactura Australia, the BioFactura subsidiary charged with development of BFI-751, initiated a phase 1 double-blind trial in April 2021 to compare pharmacokinetics, safety, and tolerability between the originator and biosimilar candidate agents.

Rani Therapeutics created a simulation video that demonstrates how the robotic pill would travel through the body to deliver a drug agent.

For Related Reading:

The Center for Biosimilars recently interviewed Anil Okay, chief commercial officer for Alvotech, about the company's biosimilar development and marketing plans. Okay explained why the company believes the high concentration formulation, AVT02, will have a marketing advantage.

View post:
Roundup: Adalimumab Biosimilar Advancements and a Biosimilar Pill - The Center for Biosimilars

Posted in Psoriasis | Comments Off on Roundup: Adalimumab Biosimilar Advancements and a Biosimilar Pill – The Center for Biosimilars

Listen to I Don’t Live Here Anymore by The War on Drugs – Pitchfork

Posted: at 9:05 pm

Here is a song that will make you long to be back in a concrete arena filled with 20,000 new friends, singing together in a way that makes you think, if only for a moment, that humanity might not be swirling toward total catastrophe. You can feel the stick on the soles of your feet just by listening to this thing. You can smell the frankfurters. Its the type of anthem that makes one of those $18 Budweisers in a commemorative plastic cup seem like a damn bargaina small price to pay to briefly heighten some sense of communion after a year and a half of pandemic seclusion.

Everything about the title track to the War on Drugs upcoming fifth album is gloriously unsubtle, including its opening lines. I was lying in my bed/A creature void of form, sings bandleader Adam Granduciel, nodding to Dylan. Been so afraid of everything/I need a chance to be reborn. And honestly, who doesnt feel like that right now? Cue the synths reminiscent of Don Henleys Boys of Summer, the drums sparkling enough to make 80s stadium-rock guru Mutt Lange bow down in appreciation, and the gospel-tinged backing vocals that urge you to believe in something beyond yourself. Granduciel has been meticulously mining classic rock sounds for more than a decade, but never quite like this; his Springsteen fandom is well-documented (his young son is named Bruce) but hes never made a song as welcoming as Hungry Heart until now.

I Dont Live Here Anymore celebrates getting to the point in life when youre no longer drowning in waves of old memories but surfing atop them. The title is not a lament but a point of pride. Amid a daydreaming verse, Granduciel wonders, Is life just dying in slow motion/Or getting stronger everyday? Then a cascade of toms and guitars give way to the majestic hook, and the answer could not be clearer.

See original here:

Listen to I Don't Live Here Anymore by The War on Drugs - Pitchfork

Posted in War On Drugs | Comments Off on Listen to I Don’t Live Here Anymore by The War on Drugs – Pitchfork

14 Best Songs of Week: The War on Drugs, Hatchie, Sam Evian, Magdalena Bay, and More – Under the Radar Mag

Posted: at 9:05 pm

14 Best Songs of Week: The War on Drugs, Hatchie, Sam Evian, Magdalena Bay, and MorePlus Tonstartssbandht, Snail Mail, My Morning Jacket, Coco, Ducks Ltd., and a Wrap-up of the Weeks Other Notable New Tracks

Sep 17, 2021By Mark Redfern (with Joey Arnone)

Welcome to the 35th Songs of the Week of 2021. It was a blockbuster week for new songs, with lots of strong contenders. We tried to show a bit of restraint and keep it to an already over-stuffed Top 12, but then we just went for it with a Top 14. I mean, whose going to tell us we cant pick 14 favorite songs? Its our website and we have no corporate overlords.

In the last week we posted interviews with Madi Diaz and Jos Gonzlez.

In the last week we also reviewed a bunch of albums.

To help you sort through the multitude of fresh songs released in the last week, we have picked the 14 best the last week had to offer, along with highlighting other notable new tracks shared in the last seven days. Check out the full list below.

1. The War on Drugs: I Dont Live Here Anymore (Feat. Lucius)

The War on Drugs are releasing a new album, I Dont Live Here Anymore, on October 29 via Atlantic. On Wednesday they shared its second single, I Dont Live Here Anymore, which features backing vocals from Lucius and has a big bold 1980s rock sound. It was shared via an Emmett Malloy-directed video that features the band performing the song on a rooftop with the downtown Los Angeles skyline behind them (which is also very 1980s), among other things.

Previously The War on Drugs shared the albums first single, album opener Living Proof, via a video for it. Living Proof was #1 on our Songs of the Week list. Then they remotely performed Living Proof on The Late Show with Stephen Colbert.

I Dont Live Here Anymore is the follow-up to 2017s A Deeper Understanding (which won the 2018 Grammy for Best Rock Album and was our #1 album of 2017), although in 2020 they released a live album, simply titled LIVE DRUGS, via frontman Adam Granduciels own Super High Quality Records.

Sessions for the album began in early 2018, when Granduciel, bassist Dave Hartley, and multi-instrumentalist Anthony LaMarca recorded some demos in Upstate New York, including early versions of some of the songs on I Dont Live Here Anymore. But the album was recorded during more than 12 sessions, in seven studios (including Electric Lady in New York and Los Angeles Sound City), and over three years, with co-producer/engineer Shawn Everett helping to guide the ship. Living Proof was recorded in May 2019 at Los Angeles Electro-Vox studios with the bands entire lineupwith the aforementioned members joined by keyboardist Robbie Bennett, drummer Charlie Hall, and saxophonist Jon Natchez. A press release says that Granduciel puts War on Drugs records together like a kind of rock n roll jigsaw puzzle.

Read our review of A Deeper Understanding here.

Read our interview with the band about making A Deeper Understanding.

Read our interview with Adam Granduciel on recording A Deeper Understanding.

2. Hatchie: This Enchanted

On Tuesday Hatchie, the dream pop project of Australian musician Harriette Pilbeam, shared a new song, This Enchanted, via a video for it. It is her first single for Secretly Canadian and her signing with the label was also announced on Tuesday. This Enchanted again finds Hatchie ably putting a modern spin on early 90s shoegaze music, producing a song thats at once pleasing to old school fans of the genre but is also accessible to contemporary listeners with no proven affinity for shoegazers. The video finds Pilbeam wandering around a city at night while wearing angel wings, as well as showing her performing the song with her band.

This Enchanted is Hatchies first single since the 2019 release of her acclaimed debut album, Keepsake, which came out via Double Double Whammy. The song came together in February 2020, while Pilbeam and her romantic partner, and Hatchie guitarist, Joe Agius (who also releases music as RINSE) were writing in Los Angeles and working with producer Jorge Elbrecht (Sky Ferreira, Japanese Breakfast, Wild Nothing).

Pilbeam had this to say about the song in a press release: This Enchanted encapsulates everything I wanted to do moving forward from my first album. I started writing it with Jorge and Joe in February 2020 and completed it from afar in lockdown later in the year. We had been talking about making something dancey but shoegaze.

Its one of the more lighthearted, lyrically vague songs of my new recordings about falling in love; its not a perfect relationship, but youre enthralled by one another and its an easy love. Its one of the most fun songs Ive written, so it was a no-brainer to pick it as my first solo release in almost two years. It feels so right to be working with a label as exciting as Secretly as I step into new territory with Hatchie. Ive been counting down the days until its release for a long time.

Read our rave 8.5/10 review of Keepsake here.

Read our 2018 interview with Hatchie on her EP Sugar & Spice.

Read our My Favorite Album interview with Hatchie on Carole Kings Tapestry.

3. Sam Evian: Time to Melt

Sam Evian is releasing a new album, Time to Melt, on October 29 via Fat Possum. On Monday he shared its second single, title track Time to Melt, via a trippy video for it. John TerEick directed the video, in which Evian meets an alien in the woods. It was filmed in the woods near Evians house.

Evian had this to say about the song in a press release: If youre familiar with tarot, I think of it as pulling the death card in a positive way. Its like facing the idea of death, which I think everyone thought about a lot this past year, maybe more than usual collectively.

He had this to add about the video: I met a lonely alien in the woods and they taught me a jig. As the night went on they convinced me to try huffing some special kind of bug spray, which opened a wormhole vortex to another dimension.

Previously Evian shared Time to Melts first single, Knock Knock, via a video for it. Knock Knock was one of our Songs of the Week.

Evian recorded the album in his own studio, Flying Cloud Recordings, in a Catskills town in Upstate New York, where he lives with his romantic partner, fellow musician Hannah Cohen after decamping from New York City. The album was recorded during the pandemic and it features Cohen, as well as remote contributions from Spencer Tweedy, Chris Bear, and Jon Natchez (The War on Drugs).

Evians last album was 2018s You, Forever.

On tour Evian will be joined by Brian Betancourt (bass), Michael Coleman (keys), Sean Mullins (drums), and Liam Kazar (guitar, synths).

4. Magdalena Bay: You Lose!

Los Angeles-based electro-pop duo Magdalena Bay (aka Mica Tenenbaum and Matthew Lewin) are releasing their debut full-length album, Mercurial World, on October 8 via Luminelle. On Wednesday they shared its third single, You Lose!, via an amusing video that features the band having a series of unfortunate events, such as losing the ice cream off a cone or running out of toilet paper.

In a joint press release statement the band say the new single is about trying to be a musician and feeling like time for success is always running out. Its definitely melodramatic, describing ourselves as aging and nearing death, but sometimes it really feels that way.

Previously the band shared the albums first single, Chaeri, via a video. Chaeri was one of our Songs of the Week. Then they shared its second single, Secrets (Your Fire), via a fun video that features the band getting sucked into a computer. Secrets (Your Fire) was #1 on our Songs of the Week list.

Mercurial World is the follow-up to 2020s A Little Rhythm and a Wicked Feeling EP. The band wrote, produced, and recorded the album themselves.

We spend all of our time together, and in some ways Mercurial World is about that particular sense of madness in containment, Lewin said in a previous press release. We live together and make art together; this immerses you in our creative, insular universe.

5. Tonstartssbandht: What Has Happened

This week Tonstartssbandht (the brother duo of Edwin and Andy White) announced the release of their 18th album, Petunia, which will be out on October 22 via Mexican Summer. They subsequently shared a Case Mahan-directed video for the albums lead single, What Has Happened. Check out the albums tracklist and cover art here.

Mahan states in a press release regarding the new video: We shot a couple hundred feet of Super 8 in the hot Orlando sun. That nocturnal bird that showed up midday gave us permission to film a heavy subject on a beautiful afternoon. Not premeditated, everything seemed to fall into place much like the bands performances that are sometimes seemingly improvised.

The vast majority of Petunia was written and recorded by the duo at their home studio in Orlando between April and August 2020. It was mixed by Joseph Santarpia and Roberto Pagano at The Idiot Room in San Francisco.

The bands previous album, Sorcerer, came out in 2017 via Mexican Summer. By Joey Arnone

6. My Morning Jacket: Love Love Love

My Morning Jacket are releasing a new self-titled album on October 22 via ATO. On Tuesday they shared its second single, Love Love Love, which features a simple but universal message: The more you give yeah/The more you get now/Go tell it to the world. It was shared via a vibrant George Mays-directed video.

Previously My Morning Jacket shared the albums first single, Regularly Scheduled Programming, via a video for it. Regularly Scheduled Programming also made our Songs of the Week list.

My Morning Jackets frontman Jim James had this to say about Love Love Love in a press release: Love Love Love is trying to steer the ship away from everything Im talking about in Regularly Scheduled Programming, and speak toward positivity and pure love, finding truth within yourself and in the world around you.

James produced and engineered My Morning Jacket over two multi-week sessions at Los Angeles, CAs 64 Sound. A press release says that the band almost called it quits prior to recording the album, but were inspired by performing four shows in summer 2019, in particular two nights at Red Rocks Amphitheatre, that encouraged them to make a new album and keep going as a band.

I hope this album brings people a lot of joy and relief, especially since weve all been cooped up for so long, said James in a previous press release. I know that feeling you get from driving around blasting music you love, or even lying in bed and crying to the music you love. The fact that were able to be a part of peoples lives in that way is so magical to us, and it feels really good that were still around to keep doing that.

My Morning Jacket released a new album, The Waterfall II, just last year via ATO after announcing it only a few days earlier. The album was the long-awaited follow-up to 2015s The Waterfall and was recorded at the same time as that album. When The Waterfall was released it was said to be part one of a two-part album and five years later they delivered on that promise. While no pre-release singles from the album were shared, when the album was released Feel You and Wasted both made our Songs of the Week list.

My Morning Jacket are currently on their first full on headline tour in five years. The band are partnering with PLUS1 so that $1.00 from every ticket will go to support non-profits working for environmental justice, racial equity, and securing access to mental health care for all.

In 2019, James released The Order of Nature, a new live album recorded with The Louisville Orchestra in collaboration with conductor/arranger/composer Teddy Abrams, via Decca Gold.

Read our interview with Jim James on the 2018 midterm elections.

Read our review of The Waterfall.

Read our interview with My Morning Jacket on The Waterfall.

7. Snail Mail: Valentine

On Wednesday Snail Mail (aka Lindsey Jordan) announced the release of her sophomore studio album, Valentine, which will be out on November 5 via Matador. Jordan also shared a new Josh Coll-directed video for the albums title track and announced a new 2021/2022 tour. Check out the albums tracklist and cover art, as well as the list of tour dates, here. The video is age restricted and can only be watched on YouTube, so weve also included the basic audio of the song.

Jordan speaks about the new album in a press release, stating: I wanted to take as much time as possible with this record to make sure I was happy with every detail before unleashing it unto yall. Referring to the process as the deepest level of catharsis and therapy I have ever experienced would be a huge understatement. Valentine is my child!

She adds, regarding the Valentine video: It was so rewarding concocting this video alongside the brilliant Josh Coll! Watching a few perverse images in my head metamorphose into this gorgeous storyline and eventually into a tangible visual was one of the most rewarding experiences of my life. We connected over a mutual interest in the intersection between terror and devastating beauty. But also Tim and Eric and watered down ginger ale, which I had to drink a shocking amount of in those drink-bombing scenes.

Valentine was written and produced by Jordan and co-produced by Brad Cook (Bon Iver, Waxahatchee). Jordans debut album as Snail Mail, Lush, came out in 2018.

Read our interview with Snail Mail on Lush. By Joey Arnone

8. Coco: Come Along

This week Coco, a trio consisting of Maia Freedman (Dirty Projectors), Dan Molad (Lucius), and Oliver Hill (Pavo Pavo), shared a video for their new single titled Come Along. It is the latest release from their forthcoming self-titled debut studio album, which will be out on October 29 via First City Artists/Awal.

The band states in a press release: The skeleton of Come Along was recorded live, all together, with Oliver on guitar, Maia on drums, and Danny on bass. The underlying chord loop plays throughout as other instruments are weaved in one by one, picking up momentum and rolling forward as everything joins in harmony. The video mimics the song in this way, portraying our individual days-in-the-life with each of us filming one another on handheld camcorders. The day culminates in our first performance together as Coco, at a house show in Olivers garage with our friends as backing band. When it all came together we were pleased with the juxtaposition of the comically low fidelity and fast-paced editing, like a homemade action movie. Just as releasing music anonymously felt natural in 2020, it now feels natural to share ourselves and delight in the connection we make with our listeners.

Last year, Dirty Projectors shared an EP anthology album, 5EPs, via Domino. By Joey Arnone

9. Still Corners: Heavy Days

On Tuesday Still Corners shared a new single titled Heavy Days. The duo also announced a new 2022 U.S. tour in tandem with a set of rescheduled Europe dates. Check out the tour dates here.

Frontwoman Tessa Murray talks about the new song in a press release, stating: Sometimes it all feels like too much, theres a lot to take in reading the news all the time. We wanted to write a reminder to put the phone down now and again and get out there and live life to the fullest while you can.

The bands most recent album, The Last Exit, came out earlier this year on their own Wrecking Light label. By Joey Arnone

10. Ducks Ltd.: Under the Rolling Moon (Feat. The Beths)

Toronto-based duo Ducks Ltd. are releasing their debut full-length album, Modern Fiction, on October 1 via Carpark. On Tuesday they shared its third single, Under the Rolling Moon, which features backing vocals from labelmates The Beths. It was shared via a video featuring the band in a Hearse in the desert. Ambar Navarro and Max Flick directed the video and they were aiming for the feel of a low to mid budget video from 1985, such as some of the videos by The Cure.

The band features Evan Lewis on lead guitar and Tom McGreevy on vocals and rhythm guitar.

Under the Rolling Moon is about trying to be there for a friend who is in a moment of crisis, says McGreevy in a press release. Some of the frustration maybe of witnessing someone elses extremely recognizable self-defeating behavior, but mostly just the feeling of caring for them, knowing they can be ok and hoping that they can find their way to seeing that.

Previously the band shared its first single, 18 Cigarettes, via a video for it. 18 Cigarettes was one of our Songs of the Week. Then they shared its second single, How Lonely Are You?, which features labelmates The Beths. How Lonely Are You? also landed on our Songs of the Week list.

Modern Fiction follows their Get Bleak EP, which was originally put out in 2019 and given an expanded reissue by Carpark this past May. It included the new song, As Big As All Outside.

Producer James Cecil (The Goon Sax, Architecture in Helsinki) put finishing touches on the album and Carpark labelmates The Beths did backing harmonies on three of the albums songs. 18 Cigarettes features Eliza Neimi on cello.

11. Absolutely Free: Remaining Light

Torontos Absolutely Free are releasing a new album, Aftertouch, on September 24 via Boiled Records. This week they shared its second single, the Pink Floyd-esque Remaining Light.

The band collectively had this to say about the new single in a press release: Remaining Light expresses the frustration felt towards invincible and corrupt institutions that uphold structural inequities, including police brutality and manufactured poverty experienced primarily by racialized communities. Written during a heat wave in the summer of 2016, the song dishearteningly remains as relevant as ever today.

Previously Absolutely Free shared the albums first single, How to Paint Clouds, via a video for it made via an AI system.

Aftertouch is the bands first full-length album in seven years. Jorge Elbrecht produced the album, which a press release describes as such: Culling from a myriad of influences that span Krautrock, New Wave, the proliferation of international psychedelic and funk compilations, and early forms of electronic dance music, Absolutely Free has created a patina of disparate but harmonic styles distinctly its own.

Aftertouch follows the bands excellent 2019 EP, Geneva Freeport. That EPs first single, Currency (Extended Mix), which featured U.S. Girls (aka Meghan Remy), was one of our Songs of the Week. Its title track also made our Songs of the Week list, as did The Endless Scroll.

Absolutely Free havent released a full-length album since their 2014-released self-titled debut album. The bands core lineup is Moshe Fisher-Rozenberg, Michael Claxton, and Matt King.

12. Makthaverskan: This Time

This week Swedish post-punk band Makthaverskan announced the release of their fourth studio album, Fr Allting, which will be out on November 12 via Run For Cover. They also shared the albums lead single, This Time. Check out the albums tracklist and cover art here.

Fr Allting features production by Hannes Ferm (HOLY), as well as the incorporation of drum machines and synthesizers, something previously not used by the band. Guitarist Hugo Randulv states in a press release: When we started the songwriting process for this album, I think we all were pretty determined to take the music in a new direction. Not necessarily that we would sound different, but to work on the songs using somewhat different methods than before. For our previous albums, we wrote the songs in our rehearsal space and pretty much recorded them the way they were. For this album, we intended the songs to be finalized in the studio and left some more room to work with.

The bands most recent album, III, came out in 2017 via Luxury/Run For Cover. By Joey Arnone

13. Marissa Nadler: If I Could Breathe Underwater (Feat. Mary Lattimore)

Marissa Nadler is releasing a new album, The Path of the Clouds, on October 29 via Sacred Bones and Bella Union. On Tuesday she shared its second single, If I Could Breathe Underwater, via a video for the song that fittingly features Nadler underwater. The song features harp playing from Mary Lattimore, a longtime friend of Nadlers. Jenni Hensler directed the video, which was partially shot with 16mm film camera.

Nadler had this to say in a press release: When I wrote If I Could Breathe Underwater, I was contemplating the possibilities of possessing various superhuman powers: teleportation, shapeshifting, energy projection, aquatic breathing, extrasensory perception, and time travel to name a few. As a lyrical device, I married those powers with events in my life, wondering if and how they could change the past or predict the future. I loved working on the melody for this song and bringing the choruses to their climaxes. Marys layered, hallucinatory shimmers really echo the netherworld of the story.

Hensler had this to say about the video: This song took on many meanings to me and I love that about it. How beauty and tragedy collide. Dreaming of having supernatural powers to change reality and have the ability to live and breathe underwater. It could also speak to the duality of existence. That we all have inner personas or shadow selves, and how we envision those different masks we wear. I chose to make something that touched on the idea of duality and the inner persona. To connect to the two worlds.

Previously Nadler shared the albums first single, Bessie, Did You Make It?, via a video for it. Bessie, Did You Make It? was also one of our Songs of the Week.

Nadler wrote and recorded the album during the pandemic and was partially inspired by binging reruns of Unsolved Mysteries as she began to notice parallels between many of its stories and her own life, as a press release puts it. On The Path of the Clouds she worked with various collaborators, including Mary Lattimore, Simon Raymonde (of Cocteau Twins and Lost Horizons and the head of Bella Union), multi-instrumentalist Milky Burgess, Jesse Chandler (Nadlers piano teacher and a member of Mercury Rev and Midlake), Emma Ruth Rundle, and Black Mountains Amber Webber. Seth Manchester (Lingua Ignota, Battles, and Lightning Bolt) mixed the album.

Nadlers last album was 2018s For My Crimes.

14. Dean Wareham: Cashing In

Dean Wareham (of Luna, Galaxie 500, and Dean & Britta) is releasing a new solo album, I Have Nothing to Say to the Mayor of L.A., on October 15 via Double Feature. Today he shared its next single, Cashing In, in which Wareham sings Im not selling out/Im cashing in. Leanna Kaiser directed the accompanying video.

Wareham had this to say about the new single in a press release: Musically I was inspired by Michael Rothers great, late-70s instrumental guitar records. And also by Peter Hook; I played the new Hooky 6-string bass I bought last year, its a big part of that early New Order sound.

Previously Wareham shared the albums first single, The Past Is Our Plaything, via a video for it. The Past Is Our Plaything was also one of our Songs of the Week.

Warehams last solo album was 2014s Dean Wareham but since then hes kept busy, including doing the soundtrack for Mistress America with his wife, Britta Phillips, and reuniting and touring with Luna.

The hard thing is just to start, Wareham says of the gap between solo albums. When I sat down and did it, the songs came pretty quickly.

Papercuts Jason Quever produced and played on the album, which also features Phillips on bass, vocals, and keys, and Roger Brogan on drums.

In terms of the albums title, I Have Nothing to Say to the Mayor of L.A., and what he would say if he actually met the mayor of Los Angeles, where Wareham and Phillips have been based since 2013, Wareham responds: Its gonna happen. But the answer is right there tooI have nothing to say.

Read more:

14 Best Songs of Week: The War on Drugs, Hatchie, Sam Evian, Magdalena Bay, and More - Under the Radar Mag

Posted in War On Drugs | Comments Off on 14 Best Songs of Week: The War on Drugs, Hatchie, Sam Evian, Magdalena Bay, and More – Under the Radar Mag