Daily Archives: September 17, 2021

ONLINE: When Gene Therapy Meets Reality – Isthmus

Posted: September 17, 2021 at 8:53 pm

press release: Virtual Saving Sight Session: When Gene Therapy Meets Reality

Thursday, September 30, 6pm

Hosted by Melanie Schmitt, MD, assistant professor // pediatric ophthalmology and adult strabismus

Saving Sight Sessions are community events featuring leading research from the Department of Ophthalmology and Visual Sciences. Please join us online for this exciting discussion.

The event is free but registration is required.

Melanie Schmitt, MD

John W. and Helen Doolittle Professor, pediatric ophthalmology and adult strabismus specialist, director of the pediatric inherited retinal degeneration clinic, co-director of the ocular genetics program

Dr. Melanie Schmitt is a respected pediatric ophthalmologist and adult strabismus specialist. Her research focuses on inherited retinal degenerations. In this engaging session, Dr. Schmitt will present on gene therapy that is available for a rare genetic eye disorder, Leber congenital amaurosis.

Dr. Schmitt earned her medical degree at the University of Wisconsin School of Medicine and Public Health. She completed her internship year and ophthalmology residency at Beaumont Hospital in Royal Oak, Michigan, followed by a pediatric ophthalmology and adult strabismus fellowship at Cole Eye Institute in Cleveland, Ohio. She joined the DOVS faculty in 2014.

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AGC boost pDNA and mRNA capacity with expansion – BioProcess Insider – BioProcess Insider

Posted: at 8:53 pm

CDMO AGC Bio will expand its Heidelberg, Germany facility to increase its manufacturing capacities for customer pDNA and mRNA projects.

The expansion, of which financial details have not been disclosed, sees contract development manufacturing organization (CDMO) AGC Biologics boost its current production capacity for plasmid-DNA (pDNA) and messenger RNA (mRNA) by adding an additional manufacturing line.

The Heidelberg expansion will also include additional warehouse capacity, a cleanroom for mRNA development and production, and a process development lab for microbial protein and cell and gene therapy projects.

Image: Stock Photo Secrets

Cell and gene therapy products have brought new promising treatments in multiple areas of high unmet medical needs. However, a record-breaking cell and gene therapy pipeline is creating vast market opportunities yet causing a manufacturing capacity shortage, a spokesperson for AGC told BioProcess Insider.

Creating new manufacturing capacity requires investments, lead time, and technical expertise. [The expansion] puts AGC Biologics in a unique position as one of the few CDMOs in the world that can provide end-to-end services for the development and manufacturing of cell and gene therapies.

The Alliance for Regenerative Medicine reported that this year there are currently 1,320 industry-sponsored regenerative medicines and advanced therapies trials ongoing globally.

According to AGC Bio, the expansion also builds on the firms decision to buy a 622,000 square-foot cell and gene therapy facility in Longmont north of Denver, Colorado from Novartis in July.

A year prior to this, AGC Bio acquired a cell and gene therapy site in Milan, Italy, added through the 240 million ($284 million) acquisition of Molecular Medicine (Molmed).

The facilitys added capabilities are expected to be fully operational in 2023 and the CDMO said it will continue to invest in our Heidelberg facility and new jobs will be created as a result of this latest expansion.

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Vaccines in your salad? Scientists growing medicine-filled plants to replace injections – Study Finds

Posted: at 8:53 pm

RIVERSIDE, Calif. Vaccinations can be a controversial subject for many people, especially when it comes to injections. So what if you could replace your next shot with a salad instead? Researchers at the University of California-Riverside are working on a way to grow edible plants that carry the same medication as an mRNA vaccine.

The COVID-19 vaccine is one of the many inoculations which use messenger RNA (mRNA) technology to defeat viruses. They work by teaching cells from the immune system to recognize and attack a certain infectious disease. Unfortunately, mRNA vaccines have to stay in cold storage until use or they lose stability. The UC-Riverside team says if theyre successful, the public could eat plant-based mRNA vaccines which could also survive at room temperature.

Thanks to a $500,000 grant from the National Science Foundation, researchers are now looking accomplish three goals. First, the team will try to successfully deliver DNA containing mRNA vaccines into plant cells, where they can replicate. Next, the study authors want to show that plants can actually produce enough mRNA to replace a traditional injection. Finally, the team will need to determine the right dosage people will need to eat to properly replace vaccinations.

Ideally, a single plant would produce enough mRNA to vaccinate a single person, says Juan Pablo Giraldo, an associate professor in UCRs Department of Botany and Plant Sciences, in a university release.

We are testing this approach with spinach and lettuce and have long-term goals of people growing it in their own gardens, Giraldo adds. Farmers could also eventually grow entire fields of it.

Giraldo and a team of scientists from UC-San Diego and Carnegie Mellon University say the key to making edible vaccines are chloroplasts. These are small organs inside plant cells which help convert sunlight into energy.

Theyre tiny, solar-powered factories that produce sugar and other molecules which allow the plant to grow, Giraldo explains. Theyre also an untapped source for making desirable molecules.

Previous studies have shown that its possible for chloroplasts to express genes which are not a natural part of that plant. Giraldos team accomplished this by sending genetic material inside of a protective casing into plant cells.

In the new study, Giraldo teamed with UC-San Diegos Professor Nicole Steinmetz to use nanotechnology to deliver more genetic material into chloroplasts.

Our idea is to repurpose naturally occurring nanoparticles, namely plant viruses, for gene delivery to plants, Steinmetz says. Some engineering goes into this to make the nanoparticles go to the chloroplasts and also to render them non-infectious toward the plants.

One of the reasons I started working in nanotechnology was so I could apply it to plants and create new technology solutions. Not just for food, but for high-value products as well, like pharmaceuticals, Giraldo adds.

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How to beat cancer? Find the genes that help it hide – Scope

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Even after decades of research, cancer cells still have secrets to spill. To that end, Stanford Medicine researchers have set out to discover the hidden drivers of cancer's insidious nature.

In a recent study led by Roarke Kamber, a postdoctoral scholar in the lab of Michael Bassik, the team identified hundreds of potential targets for cancer therapies using a new screening strategy that allows for the systematic activation and deactivation of thousands of genes -- molecular instructions that dictate a cell's fate -- in both cancer cells and immune cells.

Powered by a cutting-edge gene-editing technology known as CRISPR, the team discovered a new function for a little-researched gene called APMAP that they're hoping will lead to a new cancer treatment.

Normally, when a pathogen invades the body, the immune system quickly recognizes it as foreign. Part of the immune system known as an antibody latches on to the intruder, marking it with a molecular post-it note that says "Hey! Over here!" which signals to other immune cells, particularly macrophages, that the body needs to rid itself of this new enemy. That process is called phagocytosis -- essentially, a macrophage engulfs and eats the intruder.

Cancer has a particularly nasty ability to disguise itself so that immune cells can't recognize it as "other," and don't attack it. One of the main drivers of this invisibility is a protein called CD47, a molecular signal that scientists often refer to as a "don't eat me" signal. Cancer cells produce CD47, a deceitful signal to macrophages that the cancer cells are friend, not foe, and they don't need to be eaten. Drugs that inhibit CD47 are starting to show promising results in clinical trials, but the treatment is not foolproof and there can be problematic side effects.

"We knew that many cancer cells are still resistant to phagocytosis, even if we block the 'don't eat me' signal," said Kamber." There was a sense there are additional signals out there that have not been discovered. So we set out to find them using systematic screening."

The team published the results in Nature on September 8. Bassik is the senior author of the study and Kamber is the lead author.

Using CRISPR, Kamber and his team developed a screening method through which they individually deleted or activated each gene in a cancer cell one-by-one as it was exposed to a hungry macrophage. Then, they did the same to the genes of the macrophage to see which genes played a role in gobbling up cancer cells.

"We used CRISPR to remove every gene in the human genome, one by one, to determine which of those genes were required for cancer cells to resist phagocytosis," said Kamber.

If the team removed a particular gene and the cancer cell suddenly became "edible" to a macrophage, they knew they had found a gene that was involved in cancer cell survival.

The team identified hundreds of genes that seemed to play a role in protecting cancer cells from phagocytosis, or conversely, making them more vulnerable to it, including the one that encodes CD47. While much more research is needed to investigate the potential drug targets, the scientists zeroed in on one they found particularly intriguing.

"What was really surprising is that one of the strongest regulators of this process is a gene that's been little studied called APMAP," said Kamber. "The gene has never been linked to phagocytosis regulation before and not too much is known about what it does."

It could be an ideal candidate for a drug because without APMAP, the team found, the cancer cells were very susceptible to phagocytosis. More than 90% of cancer cells were phagocytosed in vitro without APMAP, compared to only 10-15% when the gene is active.

The team wants to pursue APMAP as a therapeutic target for cancer -- small molecules could, in theory, be used to block APMAP from working, said Kamber. Plus, he added, "It appears to have certain advantages in terms of therapy -- it's not required for the growth of normal cells." That means inhibiting APMAP would likely be safe for the body and would not cause the immune system to falsely attack any of its own healthy cells.

In addition to identifying this promising drug target, Bassik emphasized that the CRISPR-based screening strategy could be applied to a wide variety of pressing questions.

"The work not only reveals an exciting new therapeutic target," he said, "it also establishes a general strategy for investigating cell-cell interactions in diverse systems."

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Vertex Announces Letter of Intent With pan-Canadian Pharmaceutical Alliance for Public Reimbursement of CFTR Modulators Extended to Include…

Posted: at 8:53 pm

TORONTO, Sept. 17, 2021 /CNW/ - Vertex Pharmaceuticals Incorporated (Canada) (Nasdaq: VRTX) today announced that it has signed a Letter of Intent (LOI) with the pan-Canadian Pharmaceutical Alliance (pCPA), which represents an agreement in principle regarding the public reimbursement of PrTRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) for eligible patients with cystic fibrosis (CF).

Vertex Pharmaceuticals Incorporated (Canada) Logo (CNW Group/Vertex Pharmaceuticals Incorporated (Canada))

This is an extension of the LOI with the pCPA including PrKALYDECO (ivacaftor) and PrORKAMBI (lumacaftor/ivacaftor).

"This is a significant milestone for patients with CF in Canada," said Duncan McKechnie, Senior Vice President, North America Commercial Operations, Vertex Pharmaceuticals. "We would like to thank the pCPA and the participating jurisdictions for their collaborative approach. We share the urgency of the CF community to bring this process to a successful conclusion, and we will continue our work with all the provinces and territories so that eligible people with CF have the opportunity to receive TRIKAFTA, KALYDECO and ORKAMBI."

This extension of the LOI follows the positive clinical recommendation for TRIKAFTA by both the Canadian Agency for Drugs and Technology in Health (CADTH) and l'Institut national d'excellence en sant et en services sociaux (INESSS) in Quebec.

About TRIKAFTA

TRIKAFTA (elexacaftor/tezacaftor/ivacaftor and ivacaftor) is a prescription medicine used for the treatment of cystic fibrosis (CF) in patients ages 12 years and older who have at least one copy of the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. TRIKAFTA is designed to increase the quantity and function of the F508del-CFTR protein at the cell surface. The approval of TRIKAFTA was supported by positive results of three global Phase 3 studies in people ages 12 years and older with CF: a 24-week Phase 3 study (Study 445-102) in 403 people with one F508del mutation and one minimal function mutation (F/MF), a four-week Phase 3 study (Study 445-103) in 107 people with two F508del mutations (F/F), and a Phase 3 study (Study 445-104) in 258 people heterozygous for the F508del-CFTR mutation and a CFTR gating mutation (F/G) or a residual function mutation (F/RF).

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About Cystic Fibrosis

Cystic fibrosis (CF) is a rare, life-shortening genetic disease affecting more than 80,000 people globally. CF is a progressive, multi-system disease that affects the lungs, liver, GI tract, sinuses, sweat glands, pancreas and reproductive tract. CF is caused by a defective and/or missing CFTR protein resulting from certain mutations in the CFTR gene. Children must inherit two defective CFTR genes one from each parent to have CF. While there are many different types of CFTR mutations that can cause the disease, the vast majority of all people with CF have at least one F508del mutation. These mutations, which can be determined by a genetic test, or genotyping test, lead to CF by creating non-working and/or too few CFTR proteins at the cell surface. The defective function and/or absence of CFTR protein results in poor flow of salt and water into and out of the cells in a number of organs. In the lungs, this leads to the buildup of abnormally thick, sticky mucus that can cause chronic lung infections and progressive lung damage in many patients that eventually leads to death. The median age of death is in the early 30s.

About Vertex

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has multiple approved medicines that treat the underlying cause of cystic fibrosis (CF) a rare, life-threatening genetic disease and has several ongoing clinical and research programs in CF. Beyond CF, Vertex has a robust pipeline of investigational small molecule medicines in other serious diseases where it has deep insight into causal human biology, including pain, alpha-1 antitrypsin deficiency and APOL1-mediated kidney diseases. In addition, Vertex has a rapidly expanding pipeline of cell and genetic therapies for diseases such as sickle cell disease, beta thalassemia, Duchenne muscular dystrophy and type 1 diabetes mellitus.

Founded in 1989 in Cambridge, Mass., Vertex's global headquarters is now located in Boston's Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia and Latin America. Vertex is consistently recognized as one of the industry's top places to work, including 11 consecutive years on Science magazine's Top Employers list and a best place to work for LGBTQ equality by the Human Rights Campaign.

Special Note Regarding Forward-Looking Statements

This press release contains forward-looking statements as defined in the Private Securities Litigation Reform Act of 1995, including, without limitation, statements made by Duncan McKechnie in this press release and statements regarding our expectations that eligible people with CF in Canada will have access to TRIKAFTA. While Vertex believes the forward-looking statements contained in this press release are accurate, these forward-looking statements represent the company's beliefs only as of the date of this press release and there are a number of risks and uncertainties that could cause actual events or results to differ materially from those expressed or implied by such forward-looking statements. Those risks and uncertainties include, among other things, that the company ultimately may not be able to secure reimbursement in Canada, that data from the company's development programs may not support registration or further development of its compounds due to safety, efficacy or other reasons, and other risks listed under the heading "Risk Factors" in Vertex's most recent annual report and subsequent quarterly reports filed with the Securities and Exchange Commission at http://www.sec.gov and available through the company's website at http://www.vrtx.com. You should not place undue reliance on these statements. Vertex disclaims any obligation to update the information contained in this press release as new information becomes available.

(VRTX-GEN)

Vertex Pharmaceuticals Incorporated

SOURCE Vertex Pharmaceuticals Incorporated (Canada)

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JUDITH FEBRUARY: The ANC in government is a walking contradiction – Eyewitness News

Posted: at 8:52 pm

OPINION

There never seems to be a week in South Africa which does not hold some serious political consequence.

Whilst in the midst of dealing with the COVID-19 pandemic and trying to increase the momentum of our vaccination drive, the ANC has held its lekgotla, Carl Niehaus (the Radical Economic Transformer-in-Chief) has been fired by the ANC (the party is now literally financially bankrupt, to add to its ethical bankruptcy), and Jacob Zuma has been granted medical parole. Anyone who didnt see that coming has not been paying attention.

After much legal wrangling, the local government election date has been set for 1 November 2021. This was not without controversy after the Constitutional Court was asked to rule on whether elections were to take place this year.

There were no written reasons given the urgency of the matter, however, the ConCourt will be providing those in due course. This has created some confusion as to whether the order allowed for the reopening of candidate registration. The IEC has now reopened candidate registration, and this is now the subject of a legal challenge by the Democratic Alliance.

The IEC maintains that it is within its rights to reopen candidate registration given that the ConCourt said it could publish such amendments to the current timetable as may be reasonably necessary. The ConCourt will yet again be seized with the matter given the DAs urgent application.

Our ConCourt has served us well and has been a bulwark between our society and a complete collapse of the rule of law.

The Presidency released a statement this week which set out the process for the appointment of the new Chief Justice. It includes public participation and an eminent persons panel which will shortlist candidates. Ultimately, however the President decides which candidates he will refer to the Judicial Service Commission. It is important that Ramaphosa gets this one big decision right. One suspects that the public participation process, together with the eminent persons panel, is Ramaphosas way of shielding himself against the internal wrangling which will doubtless arise on this appointment within his own party.

Whoever is appointed will need to provide the requisite leadership both intellectual and administrative, to our apex court. It is fair comment that the court is in need of such leadership.

Adding to the pressure on our constitutional framework and the rule of law, Jacob Zuma is now on medical parole, a cynical act by the National Commissioner of Correctional Services, Arthur Fraser, whose contract ends soon. Fraser was moved to Correctional Services, presumably because it was a softer position than his previous one in state security?

He is anything but a dispassionate player in this saga. He is the former Director-General of the State Security Agency and the Zondo Commission has heard that Fraser was involved in marshalling a private intelligence army on Zumas behalf. It was also Fraser who was alleged to have given the so-called spy tapes to Zuma which contained details of how his arms deal corruption prosecution by the National Prosecuting Authority may have been politically tainted.

The irony, of course, is that the previous commissioner, Tom Moyane went on to head SARS with disastrous consequences. This is what happens when presidents and political parties play musical chairs with positions of import. It eventually comes back to bite.

The most obvious question would be what were Frasers reasons for rescinding the order of the Medical Parole Advisory Board who had earlier denied Zuma parole and declared that he was in a stable condition? Fraser has been quite brazenly prepared to defend his decision to over-rule the Parole Board and has granted media interviews stating that there were no legal or procedural flaws in his decision.

This decision will be taken on review - and rightly so because the public has the right to know and understand whether the decision to release Zuma on medical parole was legally rational or not?

Yet, one wonders how much more strain our legal system can endure, being consistently placed in the arena where our democratic institutions fail us and where those who are in positions of power often act with impunity

If one were being equally cynical and uncharitable, one would say that it appears that Fraser was part of the stitch-up to ensure that Zuma does not serve his prison sentence.

For his part, President Ramaphosa welcomed Zumas medical parole and wished him well. That seemed just a little obsequious when South Africans may be justified in thinking that if one ensures enough violence and mayhem, eventually ones political friends will find a way out of the sticky legal situation.

Given that Zumas former financial advisor, Schabir Shaik, was released on medical parole and was seen on the golf course not long thereafter, it is also unsurprising that South Africans are sceptical of Zumas sudden and possibly terminal illness. We know that Zuma believes he is above the law. He has repeatedly cocked a snook at the courts as well as the Zondo Commission and has shown little appetite for accounting to anyone despite his repeated claim that he longs for his day in court.

In its judgment on Zumas contempt, Justice Khampepe wrote then, If we do not intervene immediately to send a clear message to the public that this conduct stands to be rebuked in the strongest terms, there is a real and imminent risk that a mockery will be made of this court and the judicial process in the eyes of the public. The vigour with which Mr Zuma is peddling his disdain for this court and the judicial process carries the further risk that he will inspire or incite others to similarly defy this court, the judicial process and the rule of law.

How right she was. A Sunday newspaper has reported that Ramaphosa was consulted before Fraser made the decision. We need to know if that was the case and if so, the President needs to be held to account for his involvement. Has Ramaphosa himself now buckled under pressure to have his predecessor released? That would be the ultimate travesty in a country well-used to travesties of justice.

Stories are doing the rounds that Zumas supporters are preparing to give him a rousing welcome when he returns to Nkandla. If Zuma is then seen doing his usual song and dance routine and complaining about the conspiracy against him, will we still be asked to believe that he is a candidate for medical parole? A case of, Who are you gonna believe, me or your lying eyes??

During his speech at the recent ANC lekgotla, President Ramaphosa mentioned many things, including expanding the social security net. Our socio-economic reality is dire, with the most recent Quarterly Labour Force Survey making for dismal reading, with 7.8 million people unemployed in our country, 584,000 more than in the first quarter of this year. A statistic that should scream, Crisis! to any government. Yet, Ramaphosa and the ANC seem so consumed with internal crises and internal party unity that it constantly feels as if we are a country walking in treacle.

Of the violence of July, Ramaphosa said, Those that are responsible for the organising, coordinating and inciting this violence must still be brought to book. Our priority is to ensure that we do not allow such criminal behaviour to recur, and on comprehensive social security, Further work needs to be done towards the achievement of Comprehensive Social Security to ensure that all South Africans can live in comfort and dignity. This necessarily requires better alignment and linkages between social security policies and labour market policies so that beneficiaries of social support can move more readily into employment. Subject to long-term affordability, serious consideration should be given to extending further support to the unemployed, and those who are structurally marginalised.

We are mostly inured to such promises. As recent Afrobarometer data indicated, trust in democratic institutions is at an all-time low. We are also inured to the Presidents promises because, quite simply, we cannot believe that he will do as he says, or that he will commandeer those around him to do as instructed. As for those who planned the insurrection, they walk freely amongst us, unfettered by the law. This is a country where words like full might of the law are unfortunately meaningless.

This past week Public Works and Infrastructure Minister, Patricia De Lille, talked again about smart cities. Only the most sanguine amongst us would believe that a party incapable of paying its staff or registering candidates for local government elections could be a vehicle for the radical social change this country needs, let alone a smart city. We need desperately to get the little things right and then dream big. For the governing ANC that means regaining peoples trust on the little things.

Impunity is a strategy which has a limited lifespan. As we see Ace Magashule on the periphery, fighting legal battles, Niehaus dismissed and other RET forces being dealt mini blows, these have been some consequences of Ramaphosas clean-up. But we need to survey the damage that has been caused along the way and whether out of this ANC wreckage, something new can be rebirthed?

Its hard to imagine that a party cannabalising itself can be rebirthed. It certainly will not be able to hold itself together for much longer. This local government election will be instructive. We are not far away from increased coalition government. That will bring with it a new set of challenges. Surely too, the time for the almighty split within the governing party has come? Then, we might ask as Yeats did,

"And what rough beast, its hour come round at last,

Slouches towards Bethlehem to be born?"

The ANC in government is a walking contradiction and inflicts its wounds on an already wounded society.

Judith February is a lawyer, governance specialist and Visiting Fellow at the Wits School of Governance. She is the author of 'Turning and turning: exploring the complexities of South Africas democracy'. Follow her on Twitter: @judith_february

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The most successful companies infuse their business with design. Now they need to think bigger – Fast Company

Posted: at 8:51 pm

We should not underestimate the crucial importance of leadership and design joining forces. Our global future depends on it. We will either design our way through the deadly challenges of this century, or we wont make it. For our institutionsin truth, for our civilizationto survive and prosper, we must solve extremely complex problems and cope with many bewildering dilemmas. We cannot assume that, following our present path, we will simply evolve toward a better world. But we can design that better world. That is why designers need to become leaders, and why leaders need to become designers.Richard Farson, Management by Design, 2000

The year was 1997. Looking back now, it seems like prehistoric times: pre-YouTube, pre-Facebook, 10 years before Apples launch of the iPhone. It was therein a conference room of one of my corporate clientsthat I first saw a publication titled Fast Company. That particular issue featured clever cover art mimicking the iconic Tide laundry detergent. As I inched over, I saw that the headline The Brand Called You took the place of the classic P&G nomenclature. I was intrigued. I riffled through to Tom Peterss cover story and read his declaration that a new construction of our corporate selves was required in the modern marketplace. As sexy as it seemed at the time, Im not sure anyone understood the gravity of Peterss proclamation. In hindsight, this became the entry point to living our lives publicly, punctuated with a constant barrage of personal pixels. And Fast Company had the scoop.

[Photo: Celine Grouard for Fast Company]By then the magazine was nearly two years old. I was newly minted in the branding business, and the first sentence of Peterss articleIts a new brand worldbecame my mantra. I adopted Fast Company as my business bible, as it identified and revealed the cultural concepts that have continued to define the zeitgeist. My growing knowledge was further influenced by another early Fast Company writer, Roger Martin, then dean of the Rotman School of Management at the University of Toronto. His pronouncement, Business people dont just need to understand designers betterthey need to become designers, became my rallying cry.

Its hard to imagine that Martin knew the extent to which business would ultimately embrace design, but 25 years later our entire culture is now immersed in a universe fueled by creativity. Behemoth corporations including P&G, Kraft, and Coca-Cola have shown us that scale alone is not nearly enough to thrive in a world where markets are rapidly globalizing and have proven that incremental improvement on its own cant deliver a robust return on investment. Companies, such as Apple, Nike, and Target, have proven that to succeed, prosper, and make a meaningful difference in todays world the most valuable contribution comes from using the designers foremost competitive weapon: innovation.

[Photo: Celine Grouard for Fast Company]We are living in a time where business skills and design skills have now converged in ways even Roger Martin couldnt have anticipated. And the stock market agrees: A Design Management Institute study showed that companies that put design at the core of their business strategy outperformed the market by a significant margin. Fifteen rigorously selected companies institutionally using design as a strategic tool beat the S&P by 228% from 2004 to 2014. And in 2018, McKinsey & Company reported that companies using design increased their revenues and total returns to shareholders substantially faster than industry counterparts that did not.

Now, if you are developing a marketing strategy, or streamlining a manufacturing operation, or building a new system for distributionif you work almost anywhere in the world of business todayyou must be engaged in the discipline of design. This bilingual ability has resulted in companies creating superior and elegantly refined products that not only taste different, feel different, and look different; these products are also attempting to make a difference in peoples lives.

[Photo: Celine Grouard for Fast Company]The biggest, boldest, most innovative products being created today come from companies that respond to compelling needs to redesign, improve, and change the way we livehow we travel, eat, enjoy music, or support causes we believe in. In addition, for the first time in our history as a modern civilization, design has become democratized. Motivated citizens are designing their own messages and creating brands to signify their beliefs. The Black Lives Matter movement, the Pussyhat Project, and the Extinction Rebellion are non-consumer-based initiatives to redesign society to reflect the type of world like-minded individuals want to live in. The condition of branding is beginning to reflect the condition of our culture.

[Photo: Celine Grouard for Fast Company]But it is still not enough. Democratized movements and superior products are beneficial but can only do so much. In order to survive and, more importantly, to thrive, the global economy must transform itself radically. Our institutions, organizations, and communities are facing complex challenges while coping with a global pandemic, climate crisis, blatant racism, financial volatility and inequality, and political unrest. We are facing a water shortage of epic proportions and unprecedented weather disruptions. Design and business must become inextricably linked to the way in which society, culture, the environment, and politics interact. The very fate of humanity is at stake. We can no longer assume that if we follow our present path, the world will simply evolve into a better place. The way toward that better place must be carefully considered and navigated by business leaders and designers alike. We must redesign the way we think, collaborate, and innovate. We must redesign the way we live and what we value.

This essay was excerpted from the book Fast Company Innovation by Design: Creative Ideas That Transform The Way We Live and Work on sale September 21. Pre-order a copy here.

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‘Excess Ain’t Rebellion’: How Cake Has Made Moderation Sound Fun For the Past 30 Years – Billboard

Posted: at 8:51 pm

Today, the band is made up of McCrea, DiFiore, Roper, guitarist Xan McCurdy and bassist Daniel McCallum, who joined in 2016. As two of their biggest albums turn 25 and 20 -- Comfort Eagle was released July 24, 2001 -- respectively, the way that Cake carved out their own little quiet, anti-rock corner of the then-massive alt rock zeitgeist seems at risk of fading into obscurity. The consistency of their intimate, bright, familiar but not hackneyed sound and McCreas funny/sad lyrics allowed them to continue finding new audiences from the end of the grunge era through pop punks heyday. But they remained staunchly trend-averse enough that tying them into any broader narrative of 90s and early-aughts music is a challenge.

For McCrea, thats absolutely fine. In fact, its what he wanted: to make each song not just genre-less, but its own sort of solar system.

He remembers first feeling compelled to write songs as a Sacramento high schooler in the late 70s and early 80s, tinkering with verses he describes as inane and eventually learning enough guitar and bass to flesh out his ideas. At that point, McCrea had recently come across two artists that he describes as transformative: country legend Hank Williams, Sr. (Talking about minimalism, that shit is is just like a bullet) and big band titan Benny Goodman. In a way, they got me through a period of music that was wrong for me pretty unscathed, he explains.

Country, in particular, shaped McCreas sensibilities. Nobody that I take seriously as an artist can just discount country music, he says. I really loved archetypal, moving melodies that sometimes aren't all about originality, but about just communication of feeling -- I just fall for that sort of raw emotion.

McCrea sees the tension between that and his self-professed cynical, curmudgeonly, sarcastic tendencies; later, critics would sometimes only seem to hear the latter when they listened to Cakes music. To him, though, finding ways to include both of those leanings in one song is how he found his voice as a songwriter. For a lot of years, those things were kind of irreconcilable, he says. I sort of started finding a way to push them together, and allow them to coexist.

As he put it in 1996, A good song is like a teardrop in the eye of a prize-winning poodle at a world-class dog show. It doesnt matter what mood it is, as long as theres that tension, the pulling of opposites.

He moved to Los Angeles to try to make it as a songwriter, an effort that proved futile. I realized my songs weren't really one-size-fits-all enough, says McCrea. They were kind of weird and self-indulgent. When he eventually returned to Sacramento, he started waiting tables three days a week and writing songs during the other four, building up some of the library that would eventually become Cakes songbook.

Sacramento was a small enough city at that point that future bandmates crossed paths years before the genesis of Cake. Drummer Todd Roper was in a high school band with eventual Cake bassist Victor Damiani and original guitarist Greg Brown. Ropers drum teacher had negotiated a jam session for the high schooler with McCrea, then in his early twenties, that produced little besides a cassette tape. Roper brought the cassette to school and played it for his fellow music nerd friends; Brown, as he told the drummer later, was intrigued. Thats when his attraction to John started, says Roper. It was just like, Whoa, theres this songwriter in town

Brown and McCrea formed the creative core of Cake when the first iteration of the band came together in 1991. When I was working with [McCrea], I really felt the forward momentum, Brown recalls. I felt like, Something very creative is happening here. The rest of the group coalesced around their partnership.Greg and John have still, to this day a very powerful chemistry together, says Roper. I basked in the warmth that came off of that.

Getting together to listen to classic country and soul records, they brainstormed the concept for the band. We were definitely very conceptual about it, for some reason, Brown says. We were just like, Okay, we're not going with our gut -- we're gonna make something, and we're going to be intentional about it.

McCrea explained that he felt the common threads between those country and soul records should form the cornerstone of their sound, and he and Brown took notes on what specific elements they could pull from those vintage albums to support McCreas forcefully eclectic songs. A lot of times, it would sort of be filtered through Greg's ear, says McCrea. He would do things with his guitar that would sort of square things up rhythmically, in a way that I think was really, really, really smart.

It was mostly great. Sometimes difficult. Brown pauses. But I'm not going to talk about that. Mostly just a wonderful, creative kind of explosion of ideas, like a fountain that just never stopped flowing.

What Cakes members credit Brown for today, over two decades after he left the group, is helping consolidate that efficient, economical template thats made its music so recognizable. Every instrument was deliberately tinkered with, says Brown, as they searched for something that would be rhythmically compelling.

The arrangements that Greg created with John's songs stand to this day, almost note for note, says Roper. The sound was small, groovy and deliberate. Our aesthetic was one of limitations, as Brown puts it. And of course there was the trumpet, courtesy of DiFiore a particular rarity in a pre-ska-revival '90s alternative scene.

I happened to have been writing melodies for some of the songs that just sounded kind of bulbously heroic on the electric lead guitar, says McCrea. There's an emotional baggage to like, guy guitar hero stuff. I felt very strongly that we couldn't do that. But somehow when you put those same melodies on the trumpet, it cut through in the same way -- without taking up a lot of space.

Thus, Cake was born. Cake as in, to cake onto something not the tasty bakery staple, as they made clear from the start. ("It's just the sound of the word [that's appealing]," Brown told the Santa Rosa Press-Democrat in 1997. "And it's a short word that's easy to remember.") By the time they were ready to record their first single, Jolene (not a Dolly Parton cover) backed with Rock and Roll Lifestyle, in 1993, the group had established itself on the local scene, sharing bills with an array of nascent California acts including the Deftones and, memorably, Korn. Translating the sound they had refined over hours and hours of working on arrangement and then in small Sacramento clubs to disc, though, presented a new challenge.

Brown and McCrea wanted to recreate the warm sounds of the vinyl that had inspired them, almost as a reaction to the crystalline aesthetic of the CD era. They just had this cold glassy sound that we were turned off by, says Brown. With CDs, you would turn it up, and I would feel oppressed by it. With records, on the other hand, for the most part, I could turn the volume up all the way to 100 and still feel like I had space to think. Like it had breathing room.

Besides planning to literally release the single on vinyl as well as cassette, which was fairly unorthodox at the time, Brown pulled from Mark Lewisohns The Complete Beatles Recording Sessions to find sounds that were just sort of supple and inviting, yielding as opposed to aggressive a task that required he and McCrea to really work against the grain of the studio environment in the early 90s.

Part of it was by resisting the urge toward bigness and rock bluster, and having a drier approach to production and songwriting values, says McCrea. It was very difficult, in the beginning, to get sound engineers whether in the studio or live to turn things down, for Christ's sake.

That kind of scaling back and search for an intimacy of an older vintage was a self-conscious reaction to the excesses of rock to that point. It felt a little punk rock in the context of what was coming out of Seattle, says Roper. There was just a lot of really muscular grunge music sort of being foisted in people's heads, McCrea adds. What we did, within that context, felt pretty subversive. It was not without a little bit of hostility that we delivered our music product. People thought we were a joke, because we sounded small.

The initial impression of unseriousness might have been helped by their first taste of radio success with Rock n Roll Lifestyle, which made its way to college stations after their self-released debut, Motorcade of Generosity, was picked up by Capricorn Records in 1995. The track features McCreas spoken word indicting essentially all of his musical peers over a sinister riff, clarifying the bands aforementioned position as something of an alternative to the alternative. Excess aint rebellion, McCrea intones. Your self-destruction doesnt hurt them. It was certainly a fair critique, and one that resonated -- the song reached No. 31 on the Alternative Airplay chart.

It was really the first time anybody had noticed us, says McCrea. It set a sort of precedent, and I'm not sure if it was the right one -- the right first impression. But at the same time, I love the fact that I was able to communicate a critique of culture.

Though it didnt necessarily suggest the groups potential, those who listened to Motorcade in full heard a band that was already secure in its sound. If you listen to their first album, it is very much 'Cake,' says Simmons, who signed the band as a client after hearing the album. I think John McCrea is just an unbelievably wonderful songwriter. His songs are so simple and yet, they have this mysterious quality for me.

By the time the group went into the studio to record Fashion Nugget, they were veterans of the road, with a large catalog of songs that they had already refined. The group was characteristically methodical in the studio, and the band produced all its own music. Nobody was there to have a good time, says DiFiore, Everybody was there to make a good album. There was no yukking it up at all. But most of the trickiest decisions had already been made. The meat of The Distance, for example, was recorded in one take.

We played it once, and headed back to the control room to listen to the playback, says Roper. Greg's kind of bobbing his head, and he turns and he's like, Do you like the sound of the drums? I said, No, not really. Do you? He's like, Yeah, I totally did. I was like, You mean for keeps? And he was like, Yeah. I said, Well, it's your song. You can fucking keep it. And then I went to the coffee shop and got a bagel.

The song is one of very few Cake originals that McCrea didnt write himself. He took to it right away, and I didn't really understand what he saw in it so much, says Brown, who wrote the song, of McCrea. I liked the way it sounded and everything, but I thought Frank Sinatra was a much stronger choice for the single. But the record label chose it and it worked out.

Worked out might be an understatement. The surrealist Office Space-meets-vision quest video went into heavy rotation on MTV, and the song reached no. 4 on the Alternative Airplay chart, behind Bush, Sublime and No Doubt. Suddenly the bands DIY bona fides faded into the background as it moved from the college radio fringe to the epicenter of rock on the heels of another unorthodox track -- one that doesnt really begin to reflect the range uptempo funk, melancholy balladry and country twang on Fashion Nugget.

Critics were neither overwhelmingly positive nor disparaging, but words like ironic, goofy and detached were attached to the bands music with increasing frequency, especially when it came to the follow-up single, a cover of I Will Survive. It was broadly understood as what can only be described as a bit.

I don't think there's any irony in the way I deliver that song at all, says McCrea. The disco sucks movement was weirdly white supremacist, I think that's partially why everybody just assumed it must be a joke song. That's part of the damage of living in this country. We've got some baggage. (Fashion Nuggets other covers, Willie Nelsons Sad Songs And Waltzes and the pop vocal standard Perhaps, Perhaps, Perhaps, got less attention.)

They all fit in with the country and soul aesthetic that was kind of undergirding our overall sound, says Brown. If it was on our record, it was because [McCrea] just thought the song was the greatest thing in the world. Nothing we were ever doing was supposed to be that cute.

The band won sincere fans too, though -- fans that made it a very successful touring act not only in the wake of The Distance and the radio hits that followed, but right up to the beginning of the COVID-19 pandemic, almost a decade after their most recent album. But in the immediate wake of their evolution into an MTV-approved act, the pressure of their grueling schedule on the road took a toll on the band. McCrea was diagnosed with exhaustion; tour dates were cancelled.

It becomes really taxing, he says. You're mining for something that there's not very much of, and when you hit a vein of the gold and the quartz or whatever, you just keep going. Let's just rip up the mountain and get all this while we can. I did say no, as much as I could, but it was really an incredible amount of pressure from everybody.

Theres nothing particularly original about the story of fame and fortune putting a strain on creative and personal relationships. But as McCrea would say of the melodies of country songs, it can hit just as hard every time -- and the rapid transformation of Cake from Sacramento upstarts to international touring artists did just that.

The success of that song put such a strain on us personally, says Roper. We weren't strong enough between the five of us in a personal sense to hold it together, to survive the weight that was thrust onto us once the success began to arrive.

Brown and bassist Damiani left the band in 1997. I might have told you one thing back when I was 27 years old, and I left hot headed and mad about what I considered to be irreconcilable personality problems or whatever, says Brown. As 51-year-old me, I see a much larger context of what was going on in my life. Rather than get into all of it, I would just say there was a lot of turmoil at the time, and I felt like leaving Cake would be a decision that would be good for my health.

Because the band was in the middle of such a hot streak they were compelled to regroup almost immediately, bringing back bassist Gabe Nelson and hiring another local guitarist: Xan McCurdy, who is still in the band today. There's still a kind of kernel of Greg Brownness that I bring, whether it's intentional or not, says McCurdy. But there will never be anybody like Greg Brown. He is a total authentic original and a hardcore talent, and really built that group.

There are unintended consequences to becoming Cakes guitarist, though: I make jokes to my friends all the time, McCurdy adds. Like if I play in another band as a side thing I'm like, Look at this, I'm playing a chord! I haven't played a chord in six years.

In spite of the upheaval, Cake topped their initial burst of success with 1998s Prolonging The Magic and its lead single Never There -- both their biggest song to date (it was No. 1 on the Alternative Airplay chart), and probably the only major Cake single that allegations of unseriousness couldnt really stick to, given its a fairly straightforward song about longing. It was really a huge relief for me that the album didn't suck, that I could do it, says McCrea. Having established themselves as hitmakers, the group was signed by Columbia, a decision that came with more money and even more pressure.

There was some record company meddling in some of the decision making, McCrea says. It was a difficult interface between very New York, East Coast, sort of corporate culture and some weirdo home crafts project from Northern California. I think we could have used translators or something.

But it worked, again: 2001s Comfort Eagle, their first major label album, produced yet another Adult Top 40 and alternative radio hit with offbeat, call-and-response ode Short Skirt/Long Jacket and another collection of upbeat, deadpan, hyper-polished, genre-agnostic songs. It surprised me that it took off, says McCurdy of the single. It still does, honestly. I hear the na na nas, and I guess some people like the lyrics? They mostly just seem to like it in sort of a wacky way.

The crux of Cakes legacy lies in that paradox. Their most successful songs almost all fall at one end of their catalogs wide spectrum, the end with the most deadpan spoken word and lyrics that range from poetic to seeming almost free-associated. Short Skirt/Long Jacket, probably the least serious of all of them, helped cement that trend. I mean John keeps a tight grip on the creative side of things, so I'm sure he would have said, Absolutely not, if he didn't want Short Skirt to be the song that represented the group at that point, says McCurdy. But to me, it seemed a little like, Let's not f--k with the formula.

We didn't necessarily choose which songs got attention, says McCrea, but everything happened perfectly if that's what you wanted: to be misunderstood by baby boomers.

Cake released another album with Columbia, Pressure Chief, in 2004, whose prescient Luddite single No Phone reached no. 13 on the Alternative Airplay charts. Then they went dormant, leaving Columbia and relying on their draw as a touring act for the next half-decade. I felt like the whole music industry was somewhat wasteful, like a cruise ship or something, says McCrea. There was a lot of money being thrown at this industry selling a product that for most 19-year-olds was now free. So I just thought, Holy shit, we have to get off of this giant boat.

Going independent didnt hurt the band, though. Showroom of Compassion, recorded in their own solar-powered studio in Sacramento and released in 2011, was also their first no. 1 album on the Billboard 200 the lowest-selling No. 1 album in SoundScan history to that point, moving just 44,000 units, but No. 1 nevertheless -- and spawned one more alternative radio hit in the No. 4-peaking Sick of You. The realities of todays recorded music industry make releasing another Cake project less than appetizing, though theyve been writing and recording plenty in the decade since Showroom was released.

I just don't know if I'm willing to do all the hard work of making an album unless there's an equitable way of distributing it, McCrea says. I've been sort of curmudgeonly about my output. I still want to play music for my friends, but if we're talking about the economic situation, there's just something f--ked up about distribution right now.

But beyond their singles, which seem primed for a second life in TikTok challenges in the best way possible, Cake created an enviable, rich body of meaty songs and creative arrangements that stretched out what the alt 90s scene sounded like. If their stated ambition was a kind of reactive smallness, making music that sounded right on a well-worn record or a cozy club show, the scope of their aesthetic and topical curiosity and willingness to underpin almost all of their work with a critique of consumption was big. I don't know if we've influenced anybody, Brown says -- but the self-conscious rejection of genre and its attendant hierarchies have made Cakes early music sound, if not ahead of its time, than at least ageless.

They are still working together, albeit remotely, after being compelled to cancel tour dates at the beginning of the pandemic last year. McCurdy is in Portland; Roper, who returned to the band in 2016 after over a decade away, has moved to Muscle Shoals, Alabama; DiFiore is still in Sacramento. So is Brown, whose relationship with McCrea has long since been repaired. He's been actually helping me out on my projects, says Brown, who played with Damiani in the band Deathray until 2007, and still works on music as a soloist. We share ideas, and we have a really good relationship. I feel good about that, because I missed that creative energy that he and I had back in the day. I get a bit of that creative spark back.

McCrea lives with his family in Portland. When hes not writing more songs, he surreptitiously plants Western red cedar trees around Oregon a gesture towards environmental activism that he approaches with characteristic self-deprecation.

It's all self-indulgent, McCrea says. It's not going to lead to anything good. But it just feels good to do it, and so that's what I'm doing. If nothing else, it sounds like fuel for another great Cake song.

Continued here:

'Excess Ain't Rebellion': How Cake Has Made Moderation Sound Fun For the Past 30 Years - Billboard

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The Impossibility of Equity – ArchDaily

Posted: at 8:51 pm

The Impossibility of Equity

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Equity is a moving target. We who create architecture want our devotion to have a true forum of objective Equity. But motivations are not outcomes. How we judge design inevitably carries the baggage of Style and that makes universal equity in design apprehension impossible.

At this moment there are about as many women as men in architecture school. The story of two fully and fantastically successful architects, who happened to be female, says a lot about the impossibility of equity when it comes to how outcomes are perceived in architecture. Architecture is both popular trade and rarified fine art. Those two distinct worlds of judgment are often so separate as to offer zero possibility of equity between them. The two careers of these two women show how success in building and expression can be fully present in one sphere, while silent in the other.

I can compare these extraordinary humans because what I do enabled me to see them both before their bright light was shown to a wider world. I have written eight books and published the work of almost 100 architects. Rather than adopt stylistic screeds of either Modern or Traditional which absurdly try to define beauty, I included the great good work of those who were making the things I wrote about. Small houses, or additions, or other building types are the reason I write, not to polish any aesthetic lens.

In 1990, the book Common Walls/Private Homes written by John Nolon and me showed scores of multifamily projects across the country. In it, we featured an unbuilt housing project designed by Dale Mulfinger and Sarah Susanka. It was the first time Sarah Susankas work had been nationally published. In the intervening decade, Sarahs work exploded on the country, as she captured the zeitgeist of many in response to the insanity of a McMansion era of home marketing. Sarah Susanka wrote The Not So Big House.

The homes of her design shown in that and subsequent books were cleanly crafty, using natural wood, flowing space, and an essential domesticity of residential architecture. Susanka was featured multiple times on Oprah Winfreys television show and then on scores of other national media platforms. She lectured widely, wrote perhaps a dozen more books, even created a Not So Big Lifestyle movement. But the elite architectural press was near silent in celebrating her architecture. No equity of outcome between the Fine Arts world and the popular culture of glossy magazines at the supermarket check-out lines and cable TV where her work found infinite validation. There is no more well-known architect in America than Sarah Susanka.

In 1997, I wrote Expressive Details, featuring about forty architects whose work was shown in about sixty different details. Anne Fougerons work got my attention and she happily sent me two examples of it - tiny things that she was working on. In the next decade her work (as did Sarah Susankas) exploded, but Anne Fougeron was not on Oprahs TV show but rather she was featured in Architectural Record and Architecture magazines, exhibits and received unending AIA and other national awards and recognitions. Her leanly expressive beauty in building is the essence of a Modern sensibility. There is no more celebrated architect than Anne Fougeron.

Two extraordinary women created equity of outcome with all the rest of their peers. But their outcomes, in the same field, found distinct validation in fully separated worlds. Why? I think it is because the iniquitous apprehension of Style categorizes all design, without merit beyond the comfort of controlling definition. There is no equity in segregation.

Beauty is the soul of equity. How we react to everything, including the things that are designed, does not have the luxury of having a universal equity in outcome. We are either moved by the outcomes of others, or we are not. Rather than simply react to the beauty of Susankas craft or Fougerons lines, their buildings are judged Traditional or Modern. Consigned to a separate, but never equal, duality of judgment.

I wish Sarah Susankas architecture was a feature in Architectural Record Record Houses. I wish that Anne Fougerons work as a focus of Fine Homebuildings HOUSES issue. I have had features in both, when there was a tiny touch of aesthetic equity in architectural recognition. But no more. The irony of a lack of equity in their aesthetic outcomes belies the joy found in their human equity in the profession of architecture.

This article is part of the ArchDaily Topic: Equity. Every month we explore a topic in-depth through articles, interviews, news, and projects. Learn more about our monthly topics. As always, at ArchDaily we welcome the contributions of our readers; if you want to submit an article or project, contact us.

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The Impossibility of Equity - ArchDaily

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Podcast: Unraveling the QAnon Conspiracy Theory – PsychCentral.com

Posted: at 8:51 pm

Do you know someone who believes in QAnon? Are you afraid of QAnon? Have you been wondering where it comes from and what it even means?

Join us as todays guest explains how seemingly normal, intelligent, sane people believe in lizard people, pedophile cabals, and micro-chipped trackers delivered via vaccines.

Dr. Sophia Moskalenko

Sophia Moskalenko is a social and clinical psychologist studying mass identity and conspiracy theories at the Georgia State Universitys Evidence-Based Cyber Security group. Dr. Moskalenkos research on psychology of radicalization and terrorism has been presented in scientific conferences, government briefings, radio broadcasts and international television newscasts. As a research fellow at the National Consortium for the Study of Terrorism and Responses to Terrorism (NC-START) she has led research projects commissioned by the Department of Defense, Department of Energy, Department of Homeland Security, and Department of State. She has written several books, including award-winning Friction: How conflict radicalizes them and us, The Marvel of Martyrdom: The power of self-sacrifice in the selfish world, and Pastels and Pedophiles: Inside the mind of QAnon.

Gabe Howard

Gabe Howard is an award-winning writer and speaker who lives with bipolar disorder. He is the author of the popular book, Mental Illness is an Asshole and other Observations, available from Amazon; signed copies are also available directly from the author.

To learn more about Gabe, please visit his website, gabehoward.com.

Producers Note: Please be mindful that this transcript has been computer generated and therefore may contain inaccuracies and grammar errors. Thank you.

Announcer: Youre listening to Inside Mental Health: A Psych Central Podcast where experts share experiences and the latest thinking on mental health and psychology. Heres your host, Gabe Howard.

Gabe Howard: Im your host, Gabe Howard, and I want to quickly thank our sponsor, Better Help. You can grab a week free by visiting BetterHelp.com/PsychCentral. Calling in to our show today. We have Sophia Moskalenko. Dr. Moskalenko is a social and clinical psychologist studying mass identity and conspiracy theories at the Georgia State Universitys Evidence-Based Cybersecurity Group. She is also the author of Pastels and Pedophiles: Inside the Mind of QAnon. Dr. Moskalenko, welcome to the show.

Sophia Moskalenko, Ph.D.: Thank you so much for having me.

Gabe Howard: The QAnon conspiracy is everywhere. Weve heard it from the Senate floor, from the presidential pulpit, for Petes sake. Its literally been mentioned at the highest levels of government all the way down to seedy social media platform chat rooms. But what exactly is it? What is QAnon?

Sophia Moskalenko, Ph.D.: QAnon is a baseless and debunked conspiracy theory, or rather its a whole lot of different conspiracy theories under one umbrella, and they range from things like flat earth and lizard people, the idea that there are these lizard human hybrids living among us to the belief that a Satan worshiping cabal of pedophiles has taken over the control of the American government and the media. It, of course, also includes all kinds of beliefs about the COVID virus and the vaccine being either poison or something that can turn your child into LGBTQ or something that carries a micro tracking device. So there are all kinds of different conspiracy theories that all fall under the QAnon umbrella. Its really like an Amazon of conspiracy theories. Theres something there for everyone.

Gabe Howard: When I first heard about QAnon, I thought it was a group. Is it a structured group? Is there a leadership, a membership? Can you join it or is it literally just a collection of nonsense?

Sophia Moskalenko, Ph.D.: Right. There is no leadership to speak of. Initially, QAnon begun with these Q drops, these cryptic pieces of information that appeared on Chans, this like lesser used social media sites that people interpreted as though they were puzzles. And theres a lot of controversy about who the poster was for these original Q drops, who the Q so to speak was, that HBO did a documentary. And at the end, they couldnt really say definitively, but they thought it probably was more than one person posting. By today, QAnon following counts in tens of millions in the US alone, and it has spread around the world to dozens of countries. Its a very loose following. Its not like there are weekly meetings or there are some check points you need to pass in order to get to the QAnon Shangri-La. You too can go online and check out the influencers who spread QAnon content and click by click, you will end up down the rabbit hole, as they call it, where all kinds of theories are formulated and augmented and discussed about how the world really, really works. What are the secret ins and outs of how the economy is controlled and who runs the world government and who are in the cabal and so on.

Gabe Howard: Some people believe that QAnon is a cult. Some people believe that its a religion and theres yet another group of people that are like, no, no, no, its just a political movement. Im having trouble understanding exactly what it is because its so fanciful. I mean, lizard people have taken over our government? I dont understand how this gained any traction, let alone millions of followers. But for the purpose of understanding this phenomenon is QAnon a cult, is it a religion? Is it a political movement? Does it have a name?

Sophia Moskalenko, Ph.D.: Is QAnon a cult? To the best of my knowledge, of what a cult is, it usually is a pretty tight-knit face-to-face group with a very specific leadership and very specific rules for belonging and for leading. QAnon is not face-to-face, people interact with other QAnon followers through the Internet. They usually dont know them. They are not compelled to exchange their addresses and names and phone numbers and so on. There is no central leadership. Were hard pressed to even find out who the original Q drops came from. And its a really broad group. It doesnt really seem to satisfy the definition of a cult, in my opinion. Is it a religion? I am a little rusty on what defines religion, but it seems to me there has to be a central tenet or belief. And as I mentioned, QAnon is such a broad set of beliefs. And a lot of people who are QAnon followers believe some, but not others, often kind of squabble with each other online. There are these QAnon followers who sneer at those who believe in lizard people, and there are those who believe the space lasers and maybe some other QAnon followers dont. It doesnt seem like its like a religion either, because theres no central tenet as far as their beliefs are concerned.

Sophia Moskalenko, Ph.D.: So what really is it? How should we think about it? In my work on case studies that Ive analyzed for the book, really in-depth analysis of dozens of QAnon followers social media output, their own writings, their posts of videos and interviews they gave, and also looking at some of the research data that my colleagues are now putting out. It seems to me, this is my professional but personal opinion, that QAnon is kind of a zeitgeist. Its a refuge for people who feel like the society is leaving them behind. They share a number of grievances about the government, about how our country is run, the institutions that are in charge of their lives. They share a deep mistrust about science that permeates their daily lives from the food they eat, that has pesticides and hormones and all of that. And the medicines they take and the computers they use, all of the science in their lives, is giving them a lot of anxiety and uncertainty. And the most general thing that we can say about QAnon, I believe, is that its an escape route for those among us who dont feel comfortable or respected or welcomed in the society as it is right now.

Gabe Howard: But theyve turned violent. Its my understanding that the majority of the rioters at the U.S. Capitol on January 6 were QAnon believers. Isnt that concerning? I mean, tens of millions of people that are defending their beliefs with violence. Its frightening.

Sophia Moskalenko, Ph.D.: It would be frightening if it were true. The majority of people who stormed the Capitol Hill building on January 6, in fact, were not QAnon follower. How many were QAnon followers? Well, as of about a month ago, I believe the number was 61 people indicted for participation in the January 6 riot were indeed QAnon followers. Sixty-one is a very small proportion of everyone who was at the January 6 event in the Capitol Hill. So why is there this pretty widespread perception that QAnon was the driving force of that riot? I think one answer is that they just really stood out. That shaman, with the horns and the naked tattoo-covered torso. Some people who wore really bright clothing that featured large letter Q on it, some people with flags. And also the fact that the two women who were killed at the event, Ashli Babbitt, who was shot when she tried to climb a barricade that led to the door behind which the lawmakers escaped, and another woman who was trampled to death on the stairs were both QAnon supporters. So its kind of a availability heuristic that were using when were trying to imagine the crowd on January 6. Because the most visible, the most widely reported as far as the two women who were dead were indeed QAnon followers.

Sophia Moskalenko, Ph.D.: But in fact, they were a minority at that event. There is indeed a number of QAnon followers who did engage in ideologically motivated crime, including storming the Capitol Hill building. But relative to their population of tens of millions, its a tiny proportion. So QAnon is a set of shared radical beliefs. But as far as radical action is concerned, we probably shouldnt spend too much time worrying about them engaging in it. They are dangerous, though, in a different way.

Gabe Howard: Im very glad to hear that theyre not dangerous in the sense of theyre not trying to overthrow the government. Theyre not participating in violence. But you said they are dangerous. What? How are they dangerous if theyre not dangerous?

Sophia Moskalenko, Ph.D.: Well, theyre not dangerous in a terrorist threat kind of way, but think for a second how big a section of our society believes in QAnon conspiracy theories. Right? This is the same subset of our population who dont believe in our institutions and our governments authority. They dont follow government recommendations. So we already are carrying the costs of this behavior in, for example, rates of vaccination, which we know are correlated with QAnon beliefs. So people who believe QAnon conspiracy theories are a lot less likely to become vaccinated or ever intend to do so. And of course, therefore, their chances of getting sick with COVID and then ending up in a hospital seriously ill and putting pressure on our health care system are a lot higher. They may not participate in elections at the same rate, or they may participate in elections in a way that undermines them, preventing people from voting or intimidating people or discouraging them in other ways.

Gabe Howard: One of the things that I think about is that this is America. Were free to believe whatever we want, you know, freedom, of course, is the right to be wrong. Now, youve listed a lot of reasons why we should, in fact, worry about them. But where do we draw the line on this? It gets really messy quickly, right? We cant stop people from believing incorrect things. Thats not the way America works. But youve described real damage. Whats the path forward?

Sophia Moskalenko, Ph.D.: Right. We cant stop people from believing things, but at the same time, we can make sure that information on which they base their beliefs is at least somewhat balanced. We can make sure that the social media, which are the new public squares basically, they are the new media. A lot of people get their news completely from the social media. They can be fair players in this game and become more transparent about whats happening on their platforms, become a little more diligent about malicious players, whether those are domestic or foreign. We know for a fact that Russia was from the onset very much playing into spreading QAnon, multiplying QAnon content through trolls and bots and Kremlin backed media, because it is in their geopolitical interest to sow this division among the American public, which then results in the kinds of events like the January 6 storming of Capitol Hill. We need regulations for that. And we need legislation that will help to identify malicious players and those who spread harmful content so that people can make decisions based on facts than just what the algorithms of Facebook or YouTube or Twitter put in front of their eyes.

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Gabe Howard: Lets talk about turning loved ones away from QAnon. Is there any way to get through to them and bring them back to reality? Because just saying, hey, youre wrong. Here are the facts, doesnt seem to be working.

Sophia Moskalenko, Ph.D.: Yeah, in fact, its exactly the wrong thing to say, because we know from research that trying to argue with somebody about their beliefs is likely to make them even more entrenched in them. People become defensive and, in their head, even after you have finished talking with them, they will keep coming up with reasons for why they were right and you were wrong. And so a few days later, if you ask them about their beliefs, theyre going to be even more convinced of them than they were before you tried showing them the light, so to speak. So definitely dont argue with QAnon followers about facts. So what can we do? One thing that we can do that is not easy but really important is to not cut these people out of our lives and of our social circles. A really big reason why people joined QAnon or stayed with it was the social connection, especially during the COVID lockdown. The rates of QAnon following just skyrocketed because people were so lonely and so isolated in their homes, they were looking to share their emotions and their fears and QAnon offered that to them. If they could relate to people outside of QAnon not on the basis of their beliefs, but just on the basis of emotional connection. If its family, then you probably have some shared past or common loved ones, that will go a long way toward driving a wedge between them and this crazy online world.

Gabe Howard: Theres this part of me that just thinks that anybody that believes this has to be not intelligent, they have to be just extraordinarily naive or they have to be mentally ill. Is there a link there? Are intelligent people falling for this?

Sophia Moskalenko, Ph.D.: Youre not alone in that assumption or suspicion, people have expressed that a lot, even people in Washington suggested that. My own research doesnt show that intelligence is a correlate of QAnon beliefs. In other words, it doesnt seem to matter how intelligent a person is if you want to predict whether or not they will follow QAnon. So, among the QAnon followers that I researched, there were Harvard graduates, attorneys, physicians, successful small business owners, as well as high school dropouts, people of all ages, different economic backgrounds. We may get better data later, but at least for now, thats what it looks like. Mental illness, on the other hand, does seem to be much more prevalent among QAnon followers than it is in the general population.

Sophia Moskalenko, Ph.D.: Its hard to tell whether mental health problems are the cause of following QAnon, so people who are mentally unwell are more likely to seek out QAnon, or maybe following QAnon exacerbates dormant mental health problems. Or maybe theres something else that is driving both, but there is definitely a connection between the two. I am currently collecting data from, as you say, people who are sitting at home in front of their computers and asking them also about their history of mental health issues. So I will have an answer to that in a couple of months, I hope.

Gabe Howard: I love that the research is continuing on this. It really seems like QAnon took off when the former president started espousing the beliefs, so it gave it some legitimacy. Do you think that we will see this sort of die down as more polarizing political figures are in our rear view?

Sophia Moskalenko, Ph.D.: I wish the more polarizing political figures were in our rear view, but we have two congresswomen who are avid QAnon supporters and disseminators, Marjorie Taylor Greene and Lauren Boebert. And we have dozens of political candidates running in the primary who are also unabashedly QAnon supporters. And it seems like its not costing them any votes or any sponsors money. In fact, it seems like it helps them get elected. So unfortunately, I dont think were going to see QAnon kind of dying out of President Trump is, as you say, in our rear view mirror. Unfortunately, I think President Trump is not entirely in our rear view mirror.

Gabe Howard: I think that youre absolutely correct. This is dominating the news cycle. I mean, its a popular enough theory that a mental health podcast is covering it from a mental health perspective. This is not some small fringe thing. Do you think something thats giving it legs is the fact that its constantly being discussed in the media?

Sophia Moskalenko, Ph.D.: Are you proposing a conspiracy theory, Gabe?

Gabe Howard: I, its I struggle with this so much because I just I honestly believe that if you walked up to any QAnon follower and you said to them, Im a reptilian and I live under the flat earth, they would immediately call you a liar. Yet they believe that its out there. Its a dichotomy that confuses me completely, understanding that I am not a mental health professional. I am not a researcher. I am just a gentleman with bipolar who hosts a podcast and gets to talk to great researchers and doctors like you. But the, it fascinates me. And I just dont have the words to describe how anybody can fall for this.

Sophia Moskalenko, Ph.D.: I think its fair to assume that there is a number of QAnon followers who dont believe much or any of it. And for them, engaging in QAnon talk online or in-person is just a collective narrative making to vent their frustrations, to relate to people of similar political leanings. And if you put them against the wall and, you know, really interrogated them, they would say they didnt really believe any of it. For them, its just a kind of posturing. And then theres some for whom its really true. And those people, unfortunately, are probably deeply unwell. And we need to be thinking about how to provide them with mental health services that theyre not getting at the moment. And then there are a lot of people in the middle who are, like you said, you know, if you told them that you were a lizard hybrid, they would probably laugh in your face. But at the same time, they have to deal with so much on a daily basis that they have no way of ascertaining. And so they just have to take somebodys word on it. Im buying processed food at a store, and I just have to trust the manufacturing company to actually put food into it that they say they did, and occasionally turns out that they didnt do that. Same with medicine I buy for my children. You know, I just have to trust the scientist who put out research about it to be truthful instead of greedy. And occasionally it turns out they were not truthful. So people often develop this deep skepticism and suspicions of the most fundamental daily things that come from science, that come from government, and that are critically important in their lives. And so they treat everything with the same skepticism and allow for the possibility that theres poison in the food and drugs that will make you into a drug addict, even though theyre supposed to help you. And doctors who will push those drugs on you in order to get rich and that there are lizard people living out there.

Gabe Howard: Dr. Moskalenko, I can only imagine what your research is like. It had to be both fascinating and scary because Im equal parts fascinated and terrified. Do you have any final words on this phenomenon? Is this the first time that something like this to this scale has gripped America? Are we in uncharted waters here or is this just more of the same?

Sophia Moskalenko, Ph.D.: Conspiracy theories are definitely not new. In fact, most of QAnon folklore is a reiteration of some old conspiracy theory. Like, for example, the Protocols of Zion, which came out of Czarist Russia in the 18th century and claimed that a cabal of Jews were kidnapping children and worshiping Satan and drinking their blood and torturing them. So that part is not really new or surprising. What is new, though, is how far-reaching its gotten with the help of social media. Were so intimately connected through our devices all the time now. Before it would take some time and effort to get some pamphlets somewhere and read it. And the scarcity of paper and the expense of printing would make the spread of these stories much less. Now its just spreading like wildfire.

Gabe Howard: Its hard enough to move forward when everybody is using actual data, because even in science, we see different interpretations of facts. But when youre not bound by truth, everything is game. And its utterly terrifying to think that there are tens of millions of people that believe some of these things. So thank you so much for your research and your book, Pastels and Pedophiles: Inside the Mind of QAnon. Where can folks find that?

Sophia Moskalenko, Ph.D.: Its on sale at Amazon and Barnes & Noble, or you can buy it directly from Stanford University Press.

Gabe Howard: Well, thank you so much for being here.

Sophia Moskalenko, Ph.D.: Thank you for having me.

Gabe Howard: And thank you to all of our listeners. My name is Gabe Howard and I am the author of Mental Illness Is an Asshole and Other Observations. And Im also a nationally recognized public speaker. And I would love to be at your next event. You can grab a signed copy of my book with free swag or learn more about me just by heading over to gabehoward.com. Wherever you downloaded this podcast, please follow or subscribe. Its absolutely free. And you wont miss a thing. Also, take a moment and review the show. And Ill see everybody next Thursday on Inside Mental Health.

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Podcast: Unraveling the QAnon Conspiracy Theory - PsychCentral.com

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