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Daily Archives: September 16, 2021
Zamba is one of the top online casinos in the world Film Daily – Film Daily
Posted: September 16, 2021 at 6:25 am
Who doesnt love a night at the casino? Spending time alone or with friends playing casino games is some of the most fun that you can have, and nowadays you can have that fun anytime & anywhere. Thanks to Colombias careful regulation of the online gambling market, Colombian players have access to one of the most trustworthy & robust online casino markets in the world.
Whereas people in some other countries may have to spend time worrying about whether or not they can trust the casinos available to them online, Colombian players simply need to worry about which casino is going to give them the best experiences. Many offer an incredible variety of games & services, in addition to special bonuses for new & returning customers in order to stay competitive in the market.
One of the best online casinos on the market is Zamba. If you want to perfectly replicate the feeling of playing in a physical casino online, then Zamba is the place for you. They have all the juegos de casino youd expect from a top-tier physical casino, and theyve found ways to make their games even better. Come take a look at what Zamba has prepared for you.
Everyone has their favorite casino game. Whether you love blackjack, roulette, bingo, or slots, Zamba has a game that is perfect for you. To make your gaming experience even better, Zamba stocks games from over a dozen different developers, from staples like Amatic Industries to longtime digital developers like Microgaming. Youll be shocked by the vast catalog of games that you can play on Zamba.
Zamba also distinguishes themselves from their competitors by offering live casino games twenty-four hours a day, seven days a week. In other words, Zamba operates exactly like any of the best casinos in the world, but its available to you anywhere at all. By creating an account with Zamba, youre giving yourself a casino in your pocket.
The most important part of any casino is how you can actually win money. Zamba has multiple ways for you to cash out your winnings. The most popular option is to link your bank account with your Zamba account. Then, the casino is able to pay out directly to your bank. If that option doesnt work for you, Zamba also has physical locations in Colombia where you can pick up your winnings.
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Netherlands Online Gambling Association Calls for New Limits on Advertising – European Gaming Industry News
Posted: at 6:25 am
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The number of gambling players is still increasing in Italy, and the reason is simple: Italians love to gamble. Italians love casinos games such as poker, slots, jackpots, and bingo.
The game in Italy has been around for centuries. It is worth remembering that it all started with the Roman Empire, when the predecessor of the modern game of backgammon, Ludus Duodecim Scriptorum, became popular among Roman legionnaires
According to Italian criminal regulation law, gambling is illegal, be it organized in a public place or a private club. However, the Italian authority also considers that theres a difference between games of luck and games where the outcome depends on the players skill. As result of this consideration, sports-betting, lotteries, and some other activities fall into the category of legal and regulated gambling activities.
The AAMS (Amministrazione Autonoma dei Monopoli di Stato Autonomous Administration of State Monopolies) is the regulator body responsible to inspect operators and regulate gambling sector in Italy by issuing licenses for the approved operators.
Since March 2010, foreign gambling operators have been able to launch online real-money games. Before this change, gambling operators were obligated to get an Italian.
The Agenzia Dogane e Monopolio di Stato (AAMS) is responsible for ensuring a proper conduct of the online operators, preventing the violation of gambling rules and avoiding any fraud, corruption and money laundering in the Italian gambling sector.
The Italian gaming authority are responsible for issue the licenses. The licenses cover skill games, poker games, casino games, sports betting, lotteries, bingo and horse pools. The number of licenses that can be issued by AAMS is limited to 120.
The Italian regulator authority AMMS requires to pay 350,000 + 20% VAT for them for covering the technical management, administration, and supervision expenses. Online casinos must also pay a corporate tax of 27.5% and an additional tax of 0.6% that is based on their turnover on top of this. Once the license is granted, the operator can offer online gambling games for up to nine years.
It is not so easy to be qualified for an online gambling license in Italy, all operators must meet certain requirements. These include financial, technical, social, and other aspects of the business sector.
To be granted a license, the operator company must manage games in Europe with a turnover of no less than 1,500,000 in the last 2 years. The company must function at a high technical level, providing stable, secure, and easy-to-use services and be incorporated as a limited company. Other important requirements are also imposed, the operator must have reliable administration members, its official residence and a Italian-speaking technical support in one of the EU countries.
Some extra important requirements:
While the AAMS license gives Italian customers a sense of security, there are also downsides to the license as well. According to Non-aams.com, an increasing number of Italians are looking for casinos licensed by other regulatory bodies such as Curaao. This shows that not all Italian players are satisfied with the imposed Italian gaming laws and how the escape option is being.
Non-AAMS casinos are casinos that do not have an AAMS license, but usually have licenses from authorities in other countries. Are non-AAMS casinos safe to play? The answer is yes, they are reliable and safe to play too. There are many other gambling authorities offering iGaming players protection and operating around the world such as Curacao Gaming Control Board, Malta Gaming Authority, UK Gambling Commission and Swedish Gambling Authority.
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Is the Online Gambling Industry Set to Help Operators in Wales? – Wales247
Posted: at 6:24 am
The fate of the gambling industry in Wales as a whole has been talked about for some time. With 24% of Welsh customers reporting that they spend more time and money on wagering, its clear that the internet has changed the way people place bets.
But the idea that the health of the digital sector will destroy traditional betting outlets and operators in Wales doesnt appear to be true. In reality, the online markets appear to be necessary for the wellbeing of the entire industry, including physical shops and brick-and-mortar casinos.
Exposure Is Good for All Parties
An imbalance does exist between in-person and remote wagering. To put it into perspective, in 2020 in the UK, a massive 96% of people said they gambled at home. Compared to any other venue, gambling from home was the most popular form of betting. In 2019, the situation was the same as the figure was minimally lower (95%).
Several factors allow internet operators to raise their exposure among customers, whether in Wales or the rest of the UK. A prime example is the rise of digital mediums. The majority of brands now advertise on TV, through social media channels, or directly to consumers by sending SMS messages or emails. As a result, people are usually aware of a brands online presence. Another reason for a surge in internet betting is the proliferation of welcome packages and loyalty offers. From sportsbooks to casino services, a significant player within the industry will offer added value to encourage users to register or remain loyal. Thebest casino bonusesand sports gambling bonuses are eclectic to ensure there is a promo for everybody interested in gambling, from Bet & Get to Deposit & Get and deposit matches. Even no-deposit deals exist where signing up is enough to trigger freebies.
However, a singular strategy isnt powerful enough according to the data. For instance, nearly 50% of SMEs in the UK in 2019had physical shops, while 58% used online marketplaces like Amazon and eBay. This shows that a blended customer experience is critical because consumers expect a certain level of flexibility. Its already easy to see in the gambling world since websites and apps solve issues by making in-store services available, such as depositing and withdrawing money at casino cages.
Betting Shops Arent Being Left Behind
Anecdotal evidence suggests that betting shops in Wales are struggling. Many are boarded up and not operational any longer, or so the story goes. The good news is, there are just as much data to highlight that gambling providers in the Principality have solid futures ahead of them. The most powerful is 888s recent acquisition of William Hills European business from Caesars Entertainment, including 1,400 UK William Hill betting shops.
William Hill is a big brand, especially in Wales, yet it has experienced a few problems of late. In 2020, the companys total net revenue dropped by 57% in April, leaving the long-term health of traditional gambling premises in the balance. This was made worse by the fact that Caesars Entertainment made it very clear it was only bothered about the US market when it finalised theWilliam Hill dealearlier in 2021. Instead of being sold off, leaving 888 to focus solely on the online side of things, the business confirmed they are going to invest in the shops and make them a staple of the customer experience.
888 can do this based on the demand for its internet solutions. The business positions itself as a leader in online gaming operations, something thats highlighted by the number of offers and promotions it publishes. Without a profitable digital arm, the business wouldnt be able to afford to snap up William Hill International, and 1,400 physical premises would fall by the wayside.
Entain Holds Strong
On the flip side of things, MGM Resorts attempted to make a similar move to Caesars Entertainment by absorbing Entain. The name may not mean much to you, but the brands it owns, such as Ladbrokes and Coral, popular operators in Wales, will do. Unlike the Caesars deal, MGM backed out at the last minute.
Thatmeans Entains operatorswill remain in British hands, as will the physical premises they run. The even better news is that MGM has been banned from making another approach within the next six months. So, the parent company wont be changing allegiances any time soon, and Welsh gamers and bettors dont need to fret about the loss of major economic contributors.
888 has shown that the future is British. For punters, this is a good thing as brands with a background in the UK understand the cultural and societal importance of maintaining the status quo.
The online gambling industry will help operators in Wales. And, as long as it stays within British hands, the future should be very bright for everyone involved, especially customers.
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How has music culture influenced the gaming experience? – Kulture Hub
Posted: at 6:24 am
As one of the key aspects to creating the perfect gaming atmosphere in any video game, music plays a huge role in enhancing the tone and themes of each and every game you play.
From the very first monotone notes emitting from early Tetris games to the incredibly complex and expertly composed scores of modern AAA games, music, and sound design have evolved tremendously over the years.
Played to create an ambiance amongst both video games and even online casino games, a variety of the best games in the industry have been significantly impacted by sound design.
The role of music is to grab hold of the player and offer them something that visuals and controls cant always provide: a sense of belonging.
Music can often transport you to your own world, which certainly comes in handy when wanting to dive in deep into the storylines of some of your favorite games. Allowing you to truly feel the emotion of every game you play, music is the driving force behind any good games emotional core.
While the vast majority of games use music in the background, there are some that feature it as one of the key tenets of the games design.
With games like Brutal Legend requiring you to play music in order to defeat your enemies amongst their gaming storylines, many games in the industry not only use music to keep players engaged but to help them with their quests in each and every game.
Whilst the vast majority of games will focus on making sure that the player is drawn in by the visuals, those that are more focused on the music itself tap into a deeper level of engagement.
There are a range of important aspects to video games and making sound a key part of the game means that youre engaging senses which would otherwise be left as circumstantial, requiring players to pay an extra level of attention to the game.
The use of sound in video games is a win-win situation for both the players and their gaming experience and also the developers with the success of their game. Putting music and sound at the heart of any game design ensures the highest player engagement and a good user experience in all types of games.
Music plays an incredibly important role in supporting the emotional nature of every story in a game.
Games have always relied on the highest quality animations and even CGI faces to enhance their storyline, and developers now use music to add to the story, letting players know what they should be thinking or feeling at that point in the plots progression.
Just one amazing example of this is the Thomas Was Alone game, in which the players have to collect rectangles to light at the end of the level. With no words spoken, apart from the narrator, or faces even used in the game, the simple combination of lighting, animation, and most importantly, music, helps you to forge an emotional connection and certainly helps players work their way to victory.
Games like these have been developed throughout the history of video gaming where sound and music is the pinnacle point of the storyline.
Many video game musicians such as Darren Korb and Ashley Barret have made huge impacts on the way video games are seen and played by gamers all around the world.
The music in a game can be the difference between a slightly interesting game and one of the most favored and engaging games to be made in the industry. With careful consideration of the sounds and music by developers, their work and storylines that they aim to achieve can be truly felt by their players with each and every sound that is played in the game.
Music doesnt just influence video games, but it is also integral to creating the perfect atmosphere in any online casino game. Many online casino games are recognizable through their animations, music, and sound effects, so players know exactly what youre getting.
When playing casino games and slot games online, the sound design is on point when it comes to bonuses, wins, and losses, as every single sound effect is tailored to give the player feedback on how their game is going.
Just like any other game, the sound design in online casino games is always reliant on keeping the player updated, involved, and engaged. Without the right music and sound effects to set the tone of the game, many online casino games would not draw peoples attention like they do when it is used.
The importance of music in online casino games is huge as it helps contribute to the theme and storyline of each game the online casino has to offer and further enhances the feeling of being in a live casino with high-quality music to set the tone.
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John Paul II and the Social Doctrine of the Church – Catholic Outlook
Posted: at 6:24 am
When the cardinals gathered in conclave and elected Cardinal Karol Wojtya as the successor of St Peter on October 16, 1978, the choice was somewhat surprising. He was the first non-Italian pope since Hadrian VI (elected in 1522) and, above all, he came from Eastern Europe, from beyond the Iron Curtain, from Krakow in Poland. Few would have imagined that the new pontiff was about to bring a renewal to the Social Doctrine of the Church (SDC).
A look at his earlier life, however, would have given a clear indication of this direction. He had personal experience of real life in both the capitalist and communist worlds; as a professor of Ethics at the University of Lublin, Wojtya had taken an academic interest in socio-economic matters, and at the Second Vatican Council he had contributed to the composition ofGaudium et Spes(GS). What is more, his clear opposition to communism was well known.
The end of the 1970s marked an era of turbulence in the Church and in wider society. In the Church, confidence in its social doctrine had reached its lowest point. The growing prestige of Marxism was combined with criticism of the social doctrine of the Church by various theological and political currents, which accused it of being abstract, moralistic and ideological. This accusation was formulated, for example, by Marie-Dominique Chenu inLa doctrine sociale de lglise comme idologie.[1]Everything seemed to conspire to attack it.
An interview given by Wojtya a few months before his election shows that he had clear and very developed ideas on central themes of the social doctrine of the Church.[2]The questions explored his opinion on the validity of the criticism of that doctrine: specifically, whether he considered it ideological and in what sense; whether he considered it an evangelical proclamation or a teaching of natural ethics; whether it was a kind of appropriate middle ground between Marxism and liberalism, or whether it opposed both of those ideologies; whether it was outdated; whether it was capable of generating practical outcomes; and what challenges it would face.
In his answers, Wojtya showed how convinced he was of the value and validity of the social doctrine of the Church as well as the need to develop it. He expressed an ardent desire for its renewal. Once elected, Pope Wojtya had the opportunity to implement this project . He did so successfully and his contribution to the Churchs social doctrine was completely decisive. Here we propose to synthesize the teachings of his three great social encyclicals, highlighting their contributions, their ongoing validity and the internal unity they possess.
Laborem Exercens on human work
What could John Paul IIs contribution be? It was clear that he was facing a great challenge, given the ecclesial context of the time and the socio-economic crisis of the 1970s. While the decade of the 1960s had been characterized by strong and constant growth, starting in 1973 the world faced its first oil crisis, in which the price of crude oil quadrupled. Not only was the production apparatus fundamentally challenged, but activities stagnated and unemployment and inflation followed.
There was talk of a structural blockade. In addition, modern technologies became part of the work process, producing transformations comparable to those that occurred with the Industrial Revolution. It is worth noting that in August 1980, in the Gdansk shipyards, Lech Waesa and other workers founded the first independent trade union in a Soviet bloc country.
The firm decision to face all these difficulties speaks volumes for the temperament and ability of the new pontiff. If it is always true that ones origin and education play an important role in determining the formation of social ideas, in Wojtyas case this component was undoubtedly decisive. He had personally experienced working under Nazi domination and had spent a good part of his life under a communist regime.
Laborem Exercens(LE), dated September 14, 1981, expresses the thought of a Polish intellectual marked by this dual experience. His style dense, concentric, emphatic was considered by many to be the natural expression of a Slavic mindset. Direct quotations inLaborem Exercenscome from the Bible (especially the book of Genesis and the letters of St. Paul), the Second Vatican Council (in particular,Gaudium et Spes), and Thomas Aquinas. The argument takes the form of a philosophical reflection with a personalist accent. It starts with the words of Genesis to subdue the earth (LE 5) and sees in human work a participation in that of the divine creator (cf. LE 26). Placing labor in a Christological perspective (incarnation and redemption), he invites us to meditate on human work in the light of the Cross and Resurrection of Christ (LE 27).
Wojtya did not intend to repeat what his predecessors had already affirmed, but rather to highlight how human work is the essential key to the whole social question, focusing on the good of the human person: a person open to God and to others, the lord of creation and servant of other human beings. One could rightly speak, with regard to Wojtya, of a humanism with a human face. Indeed, labor, one of the elements that distinguishes humans from all other creatures, in some way constitutes our very nature. As persons, humans are therefore the subject of work (LE 6), and it is as an activity of human beings that work receives its own dignity.
Hence follows the denunciation of everything that disturbs the authentic hierarchy of values, as happens, for example, in the case of materialist economic thought, when it considers work as a mere instrument of production, evaluating it from the perspective of the market. In reality, the opposite is true: work is a good of the human person, through which he or she not only transforms nature, but also discovers his or her own identity and builds family and civil society. John Paul II spoke of the Gospel of work, which begins in the first chapters of Genesis and finds its fulfillment in Christ.
The social question, which had affected above all the world of workers and which until then had been dealt with on a national level, took on an international and global dimension in the 1980s (cf. LE 2). For this reason, in the search for solutions especially to unemployment the encyclical appealed for international collaboration through the provision of treaties and agreements between countries, and to the action of international organizations (cf. LE 18).
If human work is a means of personalization and cooperation with other people, a primordial mission and a way of associating with the creative work of God and the redemptive work of Christ, then its absence is not only an economic problem, but also pertains to the human and theological spheres. To resolve it requires the combined action of states and what the pope calls the indirect employer, that is, all the components that influence the contractual and the employment relationship.
Sensitive to proposals to change one system of ownership (i.e., the participation of workers in the management and benefits of the company), John Paul II defended in no uncertain terms the legitimacy of the wage system. He did not doubt the fact that nowadays there is no better way to achieve justice in capital-labor relations. At this point of the encyclical, the pope sums up his whole vision of the worker. The decent wage serves as the central element for verifying the justice or injustice of any socio-economic system, since it translates into concrete terms the principle of the common use of goods.[3]
Two other new aspects were class struggle and sociopolitical systems. No one ignores the fact that class struggle is a fundamental concept in Marxist theory and practice, understood as a means of eliminating the unjust division of society into two classes: the dominant and the dominated. John Paul II devoted the second part of the encyclical to an analysis of the concept and reality of the class struggle. In summary, his thought can be divided into three passages (cf. LE 1-15):
1)The class struggle exists. Marx and Engels elevated it to an ideological category, transforming it into a political category because of the tools it employs and the ends it aspires to achieve.
2)However, it should not exist, because capital and labor are causes instrumental and efficient that collaborate to the same end; earthly goods become capital thanks to labor, and behind capital and labor there are individuals who must be put in the foreground. This is the principle of the priority of work over capital: an evident truth deduced from the entire historical experience of humanity.
3)Consequently, only a system that overcomes the capital-labor antinomy is just. The principle of the priority of labor over capital is a postulate that belongs to the order of social morality.
In addition to the depth of this argument, it is necessary to highlight its novelty, especially on the second point. It is clear that the pope understood the affirmation capital is the fruit of labor in a different sense from that which it had in Marxs thought and, before him, in that of the utopian socialists. While for them and for Marx the entrepreneur is seen as having abusively appropriated the surplus value due to labor and in this sense his capital is the fruit of unjustly remunerated labor,Laborem Exercensfocused on the process of production and clarified that earthly goods become capital, that is, goods of production, by means of multiple labor, which includes many jobs. This was an original consideration, which had the merit of arguing with Marx on his own ground the analysis of history and the process of production to reach a conclusion different from his.[4]
It should also be noted that on this point the popes language was innovative; he spoke of the reality of the class struggle without evading either the term or its implications: It must be frankly recognized that the reaction against the system of injustice and harm that cried to heaven for vengeance and that weighed heavily upon workers in that period of rapid industrialization was justified from thepoint of view of social morality (LE 8).
Finally, speaking of the trade unions at the time, Walesas Solidarno (Solidarity), which Wojtya strongly supported, had not yet been recognized the pope replied to those who, hypothetically, expressed wonder at his opposition to the class struggle and simultaneous defense of trade unions as indispensable elements of social life, affirming that the trade unions were, in promoting social justice, exponents of the struggle for justice, and not concerned with eliminating the adversary (cf. LE 20).
When the encyclicalLaborem Exercenswas published, its attitude toward capitalism and socialism was met with surprise. Was that initial reaction well-founded? In the encyclical there is no shortage of criticism of capitalism and Marxism, even in their mildest forms. It accused the former even when it allows for the participation of workers and trade unions in economic life of defending private property as an untouchable principle with respect to the common good. It criticized the latter on the grounds that the transfer of ownership of goods to the state is not authentic socialism if it does not ensure the involvement of society. It reproached both of them for having fallen into the materialistic and economic error of sustaining the unnatural opposition between capital and labor and of considering the latter as a commodity or as an aspect of production, obscuring its human character. Both have allowed glaring injustices to persist, or have given rise to new ones, because they do not fully respect the dignity of the human person.
With this encyclical, John Paul II placed himself in the vanguard of the promotion of workers rights. The theme of the social question remains topical. The Secretary-General of the United Nations, Antnio Guterres, said on June 24, 2020, that the time has come to coordinate global, regional and national action to create decent working conditions for all. He pointed out that in the world, before Covid-19, increased inequality prevailed, with systematic gender discrimination, lack of opportunities for young people and frozen wages. Now, the uncontrolled increase in unemployment, especially in the most vulnerable sectors of the worlds population, and the loss of profits resulting from the pandemic will further erode social cohesion, just as they have already destabilized countries socially, politically and economically.
These considerations show us the appropriateness, reason and relevance of Pope Wojtyas subsequent encyclical.
Sollicitudo Rei Socialis on the social order
On December 30, 1987, John Paul II signed his second social encyclical,Sollicitudo Rei Socialis(SRS), on the 20th anniversary of the publication ofPopulorum Progressio. The purpose was twofold: to commemorate it and to relaunch the social doctrine of the Church.
In that period the world was divided into four regions: North, South, East and West. In Poland, the Solidarity trade union had been defying the Soviet giant since 1980 and causing a series of cracks in the seemingly monolithic bloc of socialism as envisaged by the Soviet Union. The latter, before entering an irreversible process of decline reacted strongly and proclaimed martial law in the homeland of John Paul II. In November 1982 Leonid Brezhnev died, and in 1985 Mikhail Gorbachev came to power. The economic, social and political crisis forced him to seek a dtente, which coexisted with the arms race. Those were the years of Ronald Reagans presidency, when there was talk of space shields and galactic war. It was a world in tension, desolate, in which there was an abyss between the developed parts and the Third World.
John Paul IIs praise ofPopulorum Progressiosuggested that he considered it a document full of relevance, perhaps the most eloquent document relating to the social doctrine of the Church. He recalled it (cf. SRS 5-10) and developed it. He presented a panorama of the contemporary world (cf. SRS 11-16) starting from a painful observation: today, hope for development is less alive than in 1967. In addition to justifying this statement by providing clear data, John Paul II addressed the problem of the causes, which were not only economic, but also political, social and human.
Underdevelopment is a complex phenomenon, as well as a regrettable one. Who is responsible for continuing underdevelopment, and is there anyone to whom the blame can be attributed? In any case, the encyclical goes so far as to make a courageous and prophetic denunciation. After pointing out the grave omissions of the developing nations themselves, as well as those of the First World, the encyclical firmly and rigorously affirms that it is necessary to denounce the existence of economic, financial and social mechanisms that act in an almost automatic way, perpetuating the wealth of some and the indigence of others (cf. SRS 16).
The two great obstacles to the integral development of peoples are the perverse mechanisms of an economic nature and the structures of sin created by these mechanisms. The sum of negative factors, which act in the opposite direction to a true awareness of the universal common good and the need to foster it, can create in individuals and institutions an obstacle that is difficult to overcome (cf. SRS 36). Of all of them, the most characteristic negative factors seem to be two: the obsession with profit, and the thirst for power, with the intention of imposing ones will on others at any cost (cf. SRS 37). It remains clear that the structures of sin foster moral disorder, prevent the exercise of virtue in social life, and are based on personal sinfulness.
After a description, in the wake ofPopulorum Progressio, of authentic development (cf. SRS 27-34), in which the conditions for it to be human are outlined, the encyclical presents a theological reading of modern times, starting from the concepts of conversion and solidarity (cf. SRS 35-40), in order to show the moral dimension of the problem. For John Paul II, it was regrettable that in socioeconomic analyses of the contemporary world the moral evaluation involving the category of sin or virtue is neglected.
The great affirmation of the Churchs social doctrine is that we are increasingly interdependent citizens of the Earth, and that this fact must make us increasingly supportive of one another. This conclusion can be reached starting simply from the consideration of ones own interests. This is why it is so necessary to push for the reforms needed to shape a more just world order, and to this end promote a culture of solidarity in the developed world; to accept in fact and not only in words that every person and every people deserve to be recognized and respected; to see the other as our equal, whose participation in the banquet of life we must facilitate. Acting in this way implies that we accept the consequences of our standard of living.
Here the question of international debt arises John Paul II believed that one cannot overlook the profound link between this problem and the question of the development of peoples. The instrument intended for this purpose has become a brake and, in certain cases, has accentuated underdevelopment (cf. SRS 19). Perhaps it is good to reconsider, from a moral perspective, the way in which we in the First World focus on our needs. Perhaps we need to return to considering the virtue of austerity as a means of giving the other the opportunity to have in turn, thus succeeding in uniting the giver and the receiver as fellow humans, brothers and sisters.
But, in addition to this, it should be remembered that solidarity is a Christian virtue closely related to the most characteristic aspect of the actions of those who consider Christ as their Lord: charity. It includes the solidarity of the specifically Christian dimension, total generosity, forgiveness and reconciliation. The theological foundation of solidarity, the common fatherhood of God and the fact that every person is a living image of him give believers a new criterion for understanding the world. In it primacy is given to a preferential option for the poor. They are the Lords poor, because he himself wanted to identify with them and take care of them (cf.Matt25:31-46;Psalm12;Luke1:52). The concluding part of the encyclical did not fail to cite the parables of the Good Samaritan and the rich man. When we close our eyes to the most obvious aspects of this worlds reality, we resemble the selfish rich man described in the Gospel.
The second objective was to give new life to the Churchs social doctrine: a task begun withLaborem Exercens, which had been followed by the two Instructions on Liberation Theology especially the second one that had expressed the same concepts. This ecclesial patrimony is now given a new dynamism. The pope moves decisively to call doctrine or doctrinal body the whole of the social teachings of the Magisterium of the Church, thus overcoming all reservations. He defines the social doctrine of the Church as an instrument of evangelization and of the Churchs contribution to the solution of development problems. Given its vital connection with the Gospel, it is part of the Churchs evangelizing mission.
The social doctrine of the Church is an integral part of its pastoral and teaching mission that Christ has entrusted to it. What is more, it is closely linked to the teaching of Christ. Indeed, the Church proclaims not only the teaching of Christ, but Christ himself. In this sense, her doctrine never loses its relevance. It has the objective of interpreting social realities, examining their adequacy or distance with respect to what the Gospel teaches, thus orienting Christian conduct. The pope based the validity and necessity of the Churchs social doctrine on the character of the Church as an expert in humanity, given that Christian anthropology, considering the totality of the person, illuminates human problems more than other partial visions that reduce the person to a negligible factor.
The document recalls that the social doctrine of the Church is an integral part of revelation, of the magisterium and of moral theology. Because of this evangelical and moral basis, it is not an ideology, nor is it a third way between capitalism and collectivism. These two predominant systems are reminded that the Church invites them to review their convictions and their actions, showing that she shows no preference for one or the other, as long as they respect human dignity and religious freedom. The knowledge and practice of this doctrine is recommended to all believers.
What Wojtya had hoped for in the above-mentioned interview was thus formulated in the most authoritative way.
Centesimus Annus
There has never been a more eagerly awaited encyclical thanCentesimus Annus(CA), published on May 1, 1991. There was a sense of duty to keep up the pace of commemorations ofRerum Novarum(1891), given the significant anniversary, the passage of a century. In addition, new events related to the resounding collapse of the Soviet empire seemed to require a public pronouncement from someone who had played no small part in that event.
Remember that Gorbachev, who was head of the USSR from 1985, had pursued a gradual transformation of the communist system, but this was not enough. The liberation and protest movements, which began in Poland, became widespread. The year 1989 saw the disintegration of the Soviet empire. The Berlin Wall fell and non-communist governments were formed in all of Moscows satellite states. On December 1, 1989, Gorbachev himself visited John Paul II in the Vatican. It was the Canossa of atheistic communism.
It was John Paul II himself, aware more than anyone else of these events, who presented the encyclical: an absolutely exceptional gesture. On May 1, the official date of the document, he provided the keys to interpreting the encyclical at a general audience: the Marxist system has fallen, and precisely for the reasonsRerum Novarumhad specified almost prophetically. An entire political system had collapsed, and yet the problems and situations of injustice and human suffering by which it was nourished had not been overcome.Centesimus Annuswas a commemoration aimed at the future, in the perspective of the Third Millennium. It did not limit itself to reviving memories, but, as the pope himself affirmed at the beginning and at the end of the encyclical, it proposed to look ahead, calling for a new international order in the economic and political fields.
What can we say about its content? The year 1989 is the theme of the third chapter. It could not have been otherwise. Wojtya had to express his version of the fall of Marxism in Europe. This was due to Marxisms violation of human rights, a fact that lay at the root of its economic failure. The movement that ended the Soviet system had begun in the Baltic shipyards, in the name of solidarity. There is a reference here to the Waesa trade union and a Christian attitude. Faced with the practical violation of all human rights, the response came from a peaceful struggle that was committed to respecting the human dignity of the adversary, never responding to violence with more violence. In this way the communist regime had been disarmed. John Paul II read into these events the recovery of freedom and the victory of the spirit of the Gospel.
This encyclical emphasized above all the anthropological and theological distance between Marxism and Christianity.Centesimus Annusanalyzed in incontrovertible terms the Marxist concepts of alienation and class struggle. The pope reacted to the motivations and results of unbridled capitalism with a frontal opposition, in line with all the teachings of previous popes. InCentesimus Annushe recognized that the free market, property and the benefit of entrepreneurs are positive realities (cf. CA 34) and that there are collective and qualitative needs that cannot be satisfied through market mechanisms and that must be provided for by the State (cf. CA 40).
To the key question, After the collapse of communism, is capitalism the only alternative left? Wojtya replied, If by capitalism is meant a system in which freedom in the economic sector is not circumscribed within a strong juridical framework which places it at the service of human freedom in its totality, and which sees it as a particular aspect of that freedom, the core of which is ethical and religious, then the reply is certainly negative (CA 42). The critique focuses on attitudes that concern the economic sector, but which are not inextricably linked to it. They may also be of interest to many citizens, regardless of the system in which they live or in which they believe.
Centesimus Annuslooks towards a society based on free work, enterprise and participation, where the state is truly democratic. The central thesis is that a socio-economic model inspired by the social doctrine of the Church should be pursued.
Finally, the encyclicals perspective on the debt of developing countries deserves to be taken up again. Starting from the principle that debts must be paid, the encyclical considered that they cannot be settled by imposing unbearable sacrifices. In such cases it is necessary to find ways to lighten, defer or even cancel the debt, compatible with the fundamental right of peoples to subsistence and progress (CA 35).
Conclusion
Already in his first papal homily, John Paul II urged us not to be afraid of Christ and to open to him the doors, not only of hearts, but also of the borders of states, of economic systems as well as political ones, the vast fields of culture, civilization, development.[5]Wojtya understood that, in order not to conform to the logic of the world, to which Marxism belonged, and to avoid being an ideology, Christianity had to express what was proper to it.
Among the many merits of John Paul IIs pontificate is his strong commitment to the social doctrine of the Church, giving it a clear and definitive place in the Churchs evangelizing mission. On the social question he signed three encyclicals, three solemn interventions; none of his predecessors was as prolific. It is important to remember this fact, because those three encyclicals are complementary.Laborem Exercensis devoted to what we might call microeconomic issues.Sollicitudo Rei Socialisfocuses on the core of macroeconomics, on the development of peoples.Centesimus Annusanalyzes the world in which we would soon find ourselves. The three encyclicals we have examined, which constitute the nucleus of John Paul IIs vast contribution in this field, are very rich in content. Their prophetic dimension is more than evident.
We cannot conclude these reflections without expressing admiration and gratitude for St. John Paul II: for his profound doctrine on the social question, for his breadth of vision and for his courage in addressing fundamental issues with the theological depth of always recognizing the dignity of the human person created in the image of God.
Reproduced with permission from La Civilt Cattolica and Fernando de la Iglesia Viguiristi SJ.
DOI: La Civilt Cattolica, En. Ed. Vol. 5, no.9 art. 8, 0921: 10.32009/22072446.0921.8
[1]. Cf. M.-D. Chenu,La doctrine sociale de lglise comme idologie, Paris, Cerf, 1979.
[2]. Cf. V. Possenti,Oltre lilluminismo. Il messaggio sociale cristiano, Cinisello Balsamo (Mi), San Paolo, 1992, 239-262.
[3]. J. M. Bergoglio Pope Francis, Duc in altum, il pensiero sociale di Giovanni Paolo II, in Id.,Nei tuoi occhi la mia parola. Omelie e discorsi di Buenos Aires 1999-2013, Milan, Rizzoli, 2016, 232.
[4]. With poorly disguised euphoria, the dailyFrankfurter Allgemeine Zeitungpointed out that, afterLaborem Exercens, it was no longer possible to argue the necessity of the class struggle from an intellectual standpoint.
[5]. John Paul II,Mass for the beginning of the pontificate, October 22, 1978.
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Guest Op-Ed: Cardinal Sen P. O’Malley Statement on 20th Anniversary of Sept. 11 Attacks – Revere Journal
Posted: at 6:23 am
By Cardinal Sean P. OMalley
Throughout the history of the United States, events have occurred that profoundly changed who we are as a country.
Breakthrough developments in medicine and science, and technology that allows for instantaneous communication, have provided us opportunities to improve our lives and be connected to one another in ways not previously possible.Sadly, war, socio-economic disparities, systemic racism and political divisions have made life more difficult for generations of Americans and deeply divided our society.
In the twenty years since the tragic day when America was attacked on September 11, 2001, we have witnessed great courage and bravery by our countless men and women who came to the aid and support of their brothers and sisters in the midst of crisis.First responders, many of whom ran towards danger never to return, exemplify the American spirit, and we honor them always.Flight crews facing unimaginable horror that day focused on caring for their passengers who turned to them for help in moments of fearful desperation. And the men and women of the military courageously stepped forward to defend our freedom. A shining tower of architectural beauty now calls us to the place where the World Trade Center towers once stood.The 9/11 Memorial honors the lives lost and helps us to heal from the trauma of that day while holding up Americas resolve to never forget. Memorials have also been erected at the Pentagon and in Shanksville, Pennsylvania where, in those attacks, the extraordinary heroism of citizens and those who serve to protect us saved many lives.
In the years since September 11, 2001, we have also experienced two deep and long-term economic downturns, a global pandemic that has led to more than 600,000 Americans losing their lives. And we have seen far too many people fall into poverty through no fault of their own, continuing an inequity that has for too long unfairly burdened those whose goal is to realize the dream of a better life for their families.A lack of civility and a too-quick readiness to denigrate and assign blame to others, amplified through social media, is fracturing communities and making us less trusting of our neighbors.Our brothers and sisters within the interfaith community have experienced an unprecedented amount of hate; we stand in solidarity with men and women of all faiths to combat this evil.
Almost 3,000 people lost their lives on 9/11.Many have since died from the health impacts directly attributed to the collapse of the towers.Two wars have cost thousands of American lives and also the lives of our allies and citizens in Afghanistan and Iraq.Many men and women who answered the call to defend us suffered life-altering injuries. We are now called to support them as they return to our communities.
September 11th changed all of us and our society. We owe the families of those lost on 9/11 the honor of finding ways to overcome our differences and building communities of compassion and love that unites us. We should be motivated to take meaningful action by looking past our differences and embracing a culture of mutual respect and dialogue.The Church has a role in this and endeavors to be a beacon of hope for the distressed, friend to the forgotten and helping hand to the less fortunate.
Many of us remember where we were and what we were feeling on that tragic day twenty years ago.I was in Washington, D.C., for meetings at the United States Conference of Catholic Bishops. Shortly after the attacks, we canceled our meeting and made our way to the nearby Shrine of the Immaculate Conception for Mass on the campus of Catholic University, where a crowd had already gathered to pray.With the help of the Universitys president, who made his car available, I was able to return to New England with my fellow bishops to be with the people of the Diocese of Fall River where I was bishop.
All across the world, there was a strong sense of community and solidarity.Our need to share the profound sorrow of that time that brought people together in a profound way.The events of September 11th demonstrated the fragility of human life and also our resilience and recognition of our common bond of humanity.
Remembering the events of September 11th twenty years later, we pray for the victims, the families and the survivors who may still be traumatized and whose health has been compromised by the effects of the attacks.
We pray for peace in our world.We pray for wisdom to overcome our differences.We pray for a future free of terrorism and hate. We pray for the healing that comes from communities of love for another, mutual respect and caring. And we commit to never forget those whose lives were lost that day.
Sean P. OMalley is an American cardinal of the Catholic Church serving as the Archbishop of the Archdiocese of Boston.
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Russia puts onus on US, says their military efforts in Afghanistan ‘turned to dust’ – Republic World
Posted: at 6:23 am
A top Russian security official recently slammed the Biden administrations handling of the US drawdown from Afghanistan. In an op-ed for Gazeta.Ru news, Deputy Chairman of the Russian Security Council Dmitry Medvedev said that the system that the United States established in the war-torn country could not survive without their support and American military construction efforts turned to dust after their withdrawal from the troubled nation. Medvedev added that the US failed in trying to provide military support to the previously established Afghan regime.
The Pentagon created the Afghan National Security Forces from scratch, trained and armed them. However, the developments of recent months made it clear that they were unable to exist without US support," Medvedev was quoted by TASS news agency.
Further, Medvedev went on to attack the Biden administration and said that Afghan forces showed no wish to fight without their sponsors. He added that they meekly gave up Afghanistans provinces and even left the countrys capital without a fight. Medvedev said that all US military construction efforts in the troubled nation turned to dust literally in an instant.
The top Russian official stressed that the American military presence in Afghanistan has led to catastrophic consequences including numerous terror attacks and a drug threat for the entire world. Medvedev added that a huge number of terror attacks, the country's population that lost hope for a peaceful future, the drug threat on a global scale, the destruction of the country's socio-economic sphere and political system, hundreds of American soldiers killed and servicemen of other countries perished.
It is worth mentioning that US' role in Afghanistan has come under scanner after the Talibans violent takeover of Kabul. Last week, General Mark Milley, who is the chairman of the Joint Chiefs of Staff, had also said that the collapse of the Afghan army, in the face of Taliban offensive, happened at a much faster rate. He added that it was very unexpected by pretty much everybody.
Meanwhile, as tension in Central Asia continues to exacerbate, the Russian Federation has reinforced its military bases in Tajikistan with new machine guns. According to a report by The Frontier Post, a fresh batch of 12.7 mm heavy machine guns NSV Utyos recently entered service with the 201st Russian military base to enhance its combat capabilities. Located in the cities of Dushanbe and Bokhtar, Tajikistan holds Russia's largest international military base. Notably, the arms are specifically designed to destroy manpower, lightly armoured targets, fortified firing points and enemy air assets. Although Russian President Vladimir Putin previously touted talks with the Taliban, Moscow has expressed clear apprehensions against the Islamist ideology destabilising international borders.
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Physicist’s Kickstarter To Test Whether We Are Living In A Simulation Raises $236000 – IFLScience
Posted: at 6:22 am
If we were in a hyper-realistic simulation, la The Matrix,would it be possible to find out? A team of physicists believes so, and they are trying to fund their experiment with a Kickstarter campaign to find out. Whether it's possible even test this, how, and what are the consequences of finding out are all big questions waiting to be explored.
Simulation Theory, in its most basic form, goes like this: if humans (or another species, for cuteness feel free to imagine it's puppies) continues to advance for hundreds, thousands, or even millions of years, it's a pretty safe bet that we will have alotof computational power at our finger/paw tips. If we were to expand out into the galaxy (or even further) we may harness the power of stars, or possibly even black holes.
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With all this energy and computational power, it's likely that at some point our descendants will be curious enough to run "ancestor simulations", using just a tiny fraction of the computing power available to us.
Ancestor simulations, as put forward by Swedish philosopher and Oxford University Professor Nick Bostrom in his2003 paper "Are you living in a computer simulation?", is the idea that future generations might have the computing power to run simulations on our forebears, and imbue these simulations with a sort of artificial consciousness. If this has already happened, this would mean the vast majority of people are simulations by the advanced descendants of the original humankind, and if that's the case, it's more rational to assume you are one of the simulations rather than one of the original biological humans.
In his paper, Bostrom proposes three possible scenarios:
1) The fraction of human-level civilizations that reach a stage where they are able to run these simulations is very close to zero.
I.e. it's likely we'll get wiped out before we reach a point where we are able to perform such tests.
2)The fraction of posthuman civilizations that are interested in running ancestor simulations is very close to zero.
In other words, our species has changed so much by that point that we are no longer interested in running simulations, and no curious individuals have access to the power to create them, or else running these simulations is banned.
3)The fraction of all people with our kind of experiences that are living in a simulation is very close to one.
If the other two are false, then we are left with option number three: our species develops the required technology and starts creating an incomprehensible number of ancestor simulations (over time). This would mean that the vast majority of "people" with experience of living on Earth are... inside a simulation, they just don't know it.
So far, so philosophical, but can we test it? Well, if you make a few assumptions about the limits of potential simulations, then it might just be possible.
In 2017, a group of physicists proposed a few methods of finding out in their paper "On Testing the Simulation Theory"withvarying degrees of complexity. Their idea rests on the assumption that the simulation would have limited resources, and so isn't simulatingeverythingin the universe all at the same time. As such, the simulation would act much like a computer game, only rendering the parts of the simulation that are being observed by a "player" at the time. Sort of like how in the background of Super Mario, the designers chose not to simulate the entire observable universe off-screen, to save on computer power (a wise move).
The key to finding out whether we are in a simulated universe or a real one is to find out when information becomes available tous, the observers.
"To save itself computing work, the system only calculates reality when information becomes available for observation by a player, and to avoid detection by players it maintains a consistent world, but occasionally, conflicts that are unresolvable lead to VR indicators and discontinuities (such as the wave/particle duality)," the authors wrote in the paper.
Should it only be at the time of observation by an observer (and not apparatus), the team suggests this would be evidence that it is only being "rendered" at the point of observation, meaning that we are living in a simulation.
Testingthis, the team says in the paper, isn't as complicated as it sounds. Though, obviously, it's still very complicated and involves the double-slit experiment. It all revolves around forcing "the VR rendering engine to create discontinuities in its rendering or produce a measurable signature event within our reality that indicates that our reality must be simulated."
In the double-slit experiment, singlephotons are fired at a double-slit cut into ascreen. If you do thisand look at the buildup of impacts on the screen, you will see a pattern emerge, as shown below. This pattern is what you'd expect if the photons were acting as waves.
So far, so simple. Now, if youdetectwhich slitthe photons are going through (imagine a beep every time a photon goes through the top slit, if it pleases you) the pattern that we get is two lines, as if the photons were behaving as particles (see below video).
Turn off the detector, and we're back toseeing the interference pattern (the waves seen above). Having or not having access to the "which way" data (essentially knowing which slit the photon went through) determines whether the photon acts as a particle or a wave. Photons can behave as either particles or waves, but cannot be observed as both at the same time.
If your brain hurts, imagine how quantum physicists feel every moment of their waking lives. But, for the authors of the 2017 studyitcouldgive us an opportunity to find out if we're real, which would be nice to know, even if it isn't going to imbue you with the power of Neo fromThe Matrix.
"The following experiments are designed based on the hypothesis that the availability of which-way data to an observer is the key element that determines the pattern found on the result screen: the simulated content (the virtual reality) is computed and available to be rendered to an experimenter only at the moment that information becomes available for observation by an experimenter and not at the moment of detection by an apparatus," the authors wrote.
By using a series of abstractions, they propose that it might be possible to find (should we live in a simulation) that the information is only given to us at the point of observation. To do this, they try to create versions of the double-slit experiment that would create a paradox.
Two strategies can be followed to test the simulation theory," they explain. "1: Test the moment of rendering. 2: Exploit conflicting requirement of logical consistency preservation and detection avoidance to force the VR rendering engine to create discontinuities in its rendering or produce a measurable signature event within our reality that indicates that our reality must be simulated."
In one of the simplest of their proposed experiments, the which-way dataand screen data are collected on two separate USB drives, and not seen by an experimenter. Keep doing this, and you have a lot of flash drives that contain which-way data, and screen data. You then destroy the which-way data USBs based on a coin flip (heads you survive, tails you die like Anton Chigurh from No Country For Old Men, but in a lab coat).
"Destruction must be such that the data is not recoverable and no trace of the data is left on the computer that held and transferred the data. For n even, one can replace the coin-flipping randomization by that of randomly selecting a subset composed of half of the pairs of USB flash drives containing which-way data for destruction (with uniform probability over such subsets)," they say in the paper.
"The test is successful if the USB flash drives storing impact patterns show an interference pattern only when the corresponding which-way data USB flash drive has been destroyed."
I.e. if you open up the screen data and see wave patterns when the corresponding which-way USB stick has been destroyed, that would mean that the simulation had rendered reality at the point of observation (you opening the file) and not when observed by the detector.
Of course, the simulation could be clever enough that it knows of intent and will find tricksier ways of concealing this from you, so should this not work, the team propose a series of ever more complex ways that you could test the system (if it exists). They even started a Kickstarter in order to fund the tests, which has raised over$236,590so far.
Of course, if we find out that we'renotliving in a simulation that has implications too. Going back to Bostrom's proposal, it would mean that we are looking at option 1 or 2: we either don't make it as a species, or become something virtually unimaginable. Both of which might be preferable to finding out that we arein a simulation. Ifthat happened it could ruin whatever "they" were testing by running the simulation in the first place. They might simply turn us off.
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Baylor College of Medicine Developed a Novel Approach to Select Subjects for Gene Experiments More Convenient and Faster than Fruit Fly Screening…
Posted: at 6:21 am
Geneticsare among the base of the biology field as well as disease studies. Numerous genetic research is gradually culminating every year, and more medical and technological advancements are surfacing because of our gene knowledge developments. In a new study, Baylor College of Medicine scientists has developed a new approach to observe and gather data from genetic manipulations that occur in a selected organism without even going through every variant of the same subject. The novel approach was conducted with the help of a drug-based genetic platform which the experts also constructed.
(Photo: FEIPhenom / WikiCommons)
The new study enumerated the functions biologists can utilize through gene equipment. In addition, the authors of the study included several of the main functions the new technology can be applied with. The paper also showed other additional configurations for the drug-based gene platform to work at its best, including setting it up, processing specimens, and analyzing information from the examination. Moreover, the technology is revealed to have the capacity to work with other traditional methods used in biological studies.
The new genetic platform is composed of several devices and resources that could help any gene-related investigation be convenient, more efficient, and faster than its predecessors. Among the most important part of gene technology is the plasmid library that could be a reference for scientists in numerous experiments and prevent them from going through a separate and complex experiment to find specifics needed for the main research.
Baylor's Verna and Marrs McLean Department of Biochemistry and Molecular Biology expert and lead author of the study Nick Matinyan said in a PhyOrgreport that they selected the Drosophilaor fruit fly as a subject for the study as it is the most well-observed specimen in most genetic researches and gives comprehensive results in biological processes such as genetic mutations. In addition, the fruit flies are an effective subject that expresses notable results that helped many studies on health and disease.
ALSO READ: Rockefeller University Developed a 3D Imaging to Capture How Ribosome Assembly Works in Nucleolus For the First Time
The usual study that involves the help of fruit flies requires plenty of variants of the insect. Through the process, the fruit flies are reintroduced to a community before undergoing examinations. From there, a specific subject expresses the most precise genes preferred by the research. During the selection, there are tags added to the genes of the selected subjects for the experts to precisely differentiate the specimens from the rest of the group.
The genetic tagsbeing normally present in the fruit flies have been concluded in the previous studies, which eases the painstaking process. While the process has effectively proven its advantage and has worked for many years in genetic ventures, the co-author of the study Koen Venken said that the fruit fly method is a downside. To procure specific subjects, researchers must screen thousands of flies manually before even selecting the best specimen. The normal process is truly time-consuming and somewhat frustrating.
With the novel technology, experts can now run experiments with the help of a subject that has not been selected from a vast number of potential candidates. The approach uses a drug-resistance tag that will allow experts to easily determine the right specimen once it survives the specialized exposure, eliminating unfit candidates and leaving out the best ones for genetic investigations. The study was published in the journal Cell Reports, titled "Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila."
RELATED ARTICLE: Gold-Mantled Ground Squirrels Personalities Similar to Humans Like Being Shy, Social, or Bold That Is Beneficial for Ecosystem
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Baylor College of Medicine Developed a Novel Approach to Select Subjects for Gene Experiments More Convenient and Faster than Fruit Fly Screening...
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5 Gene Therapy Stocks Back in Focus on AbbVie/Regenxbio Deal – Yahoo Finance
Posted: at 6:21 am
On Sep 13, AbbVie ABBV announced a deal to co-develop and co-commercialize Regenexbio's RGNX investigational gene therapy for chronic retinal diseases like wet age-related macular degeneration wet AMD.
RGX-314 is being evaluated in a pivotal study for wet AMD, utilizing the subretinal method of delivery. It is also being studied in two separate phase II studies for diabetic retinopathy (DR) and wet AMD utilizing in-office suprachoroidal delivery.
AbbVie will make a $370 millionupfront payment to Regenxbio for rights to RGX-314. Additionally, Regenxbio will also be entitled to milestone payments of up to$1.38 billion. Per the deal, while Regenxbio will be responsible for the completion of the ongoing studies of RGX-314, AbbVie will share costs for future studies, which include a second pivotal study for wet AMD utilizing subretinal delivery.
AbbVies latest gene therapy deal has brought this space once again in focus.
Gene therapy is set to become one of the most vital spaces with high prospects in the biotech sector. Scientists have been investigating gene therapies for more than 50 years. In this, rapidly-growing field, genetic, or inherited, diseases are treated by repairing or replacing the faulty genes that cause them. The idea is to see if a healthy or functional gene can be used to restore the function of a defective or mutated gene.
The promising gene therapy approach is being evaluated for varied diseases, such as hemophilia, Duchenne muscular dystrophy (DMD), Parkinson's disease, eye disease, and cancer among others.
A few FDA-approved gene therapy products are Roches subsidiary, Spark Therapeutics Luxturna to treat biallelicRPE65mutation associated retinal dystrophy and Novartis subsidiary, AveXis Zolgensma for spinal muscular atrophy. Both these drugs are the first and the only gene therapy FDA-approved products of their kind. Some gene therapy cancer medicines like Bristol-Myers Abecma and Breyanzi, Novartis Kymriah, and Gileads Yescarta and Tecartus are also approved by the FDA for some lymphoma/leukemia indications.
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Given the potential of gene therapies to treat complex diseases, the companies developing candidates using gene therapy that are a mix of large and small firms, are in focus. A successful medicine developed by any of these companies can have the potential to generate annual revenues of $1 billion or more. All the five companies have a Zacks Rank #3 (Hold). You can see the complete list of todays Zacks #1 Rank (Strong Buy) stocks here.
uniQure N.V QURE
This company is a promising player in the gene therapy space. It is engaged in creating a pipeline of innovative gene therapies that have been developed both internally and through collaborations.
The company is developing AAV5-based gene therapy, Etranacogene dezaparvovec in late-stage studies for hemophilia B. A biologics licensing application (BLA) for Etranacogene dezaparvovec is expected to be filed in the first quarter of 2022. Also, a phase I/II study is ongoing for another gene therapy candidate, AMT-130 for Huntingtons disease in its portfolio.
In June, uniQure announced the planned acquisition of Corlieve Therapeutics, a France-based pre-clinical gene therapy company.
Sarepta Therapeutics SRPT
Sareptas lead gene therapy candidate is SRP-9001, an AAV-mediated micro-dystrophin gene therapy, which is being evaluated in a phase I/II study for DMD. The company plans to initiate a pivotal clinical studythis year. The promising candidate has also led Roche to sign a collaboration deal with Sarepta. The company plans to seek FDAs approval to start a pivotal study on its other gene therapy candidate, SRP-9003, in 2021 to evaluate it in patients with Limbgirdle muscular dystrophy (LGMD) type 2E. The company has several other pre-clinical and clinical-stage gene therapy candidates targeting additional indications like Rett Syndrome, cardiomyopathy, Emery-Dreifuss muscular dystrophy type 1, and multiple sclerosis.
MeiraGTx Holdings MGTX
MeiraGTx along with partner J&J plans to begin a phase III study on its lead pipeline candidate, AAV-RGPR as a treatment for patients with X-Linked retinitis pigmentosa (XLRP) in the second half of 2021. It will also initiate a pivotal phase III study on AAV-RPE65 for patients with RPE65-associated retinal dystrophy in the second half of 2021.
It also has a phase I study ongoing on AAV-AQP1 for grade 2/3 radiation-induced xerostomia and plans to file an investigational new drug application later this year to begin clinical studies for another candidate AAV-GAD for Parkinsons Disease.
Voyager Therapeutics VYGR
Voyager is developing gene therapies with its novel proprietary AAV capsids that have a significant potential to be more reliably on-target with less risk of dose-limiting toxicities. It has a rich early-stage/pre-clinical pipeline of new and second-generation programs in Huntingtons disease, Monogenic ALS (SOD1), spinal muscular atrophy, and diseases linked to GBA1 mutations.
Solid Biosciences SLDB
Solid Biosciences lead gene therapy candidate is SGT-001, which is being evaluated in a phase I/II study in patients with DMD. Further, pre-clinical studies on its next-generation DMD gene therapy program, SGT-003, are progressing rapidly.
Some other key names in the gene therapy space are Wave Life Sciences, Sangamo Therapeutics, Regenxbio, Pfizer, and Roches subsidiary Spark Therapeutics.
Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free reportSarepta Therapeutics, Inc. (SRPT) : Free Stock Analysis ReportAbbVie Inc. (ABBV) : Free Stock Analysis ReportuniQure N.V. (QURE) : Free Stock Analysis ReportVoyager Therapeutics, Inc. (VYGR) : Free Stock Analysis ReportREGENXBIO Inc. (RGNX) : Free Stock Analysis ReportSolid Biosciences Inc. (SLDB) : Free Stock Analysis ReportMeiraGTx Holdings PLC (MGTX) : Free Stock Analysis ReportTo read this article on Zacks.com click here.Zacks Investment Research
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5 Gene Therapy Stocks Back in Focus on AbbVie/Regenxbio Deal - Yahoo Finance
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