Daily Archives: August 22, 2021

The onset of gene therapy and development in tissue engineering, as well as stem cells, are boosting the regenerative medicine market. The rising regulatory approvals for the growth of advanced therapy medicinal products will propel growth in the market. There has been an urgent requirement to develop new therapies for the treatment against SARS-COV-2 to cure patients. Different initiatives are also taken for the manufacturing of cell and gene therapy.

The increasing number of regenerative medicine products, growing investments in research activities for regenerative medicines, and rising number of cancer, genetic disorders, and chronic diseases are further creating lucrative opportunities in the regenerative medicine market. Further, private agencies and government bodies have increased investments and are also conducting different programs for improvements in the R&D activities in the regenerative medicine market. Furthermore, the companies are making collaborations to strengthen R&D abilities to ensure their reach at local as well at global platforms.

Get Brochure of the Report @ https://www.tmrresearch.com/sample/sample?flag=B&rep_id=1889

Regenerative Medicine Market: Key Trends

The researchers perspective towards regenerative medicine has been revolutionized with the technological advancements in the therapies that are based on stem cells. The technical progress in stem cell therapy has boosted regenerative medicine developments. For example, haematogenic stem cells are used for the treatment of blood disorders and leukemia. Further, nanotechnology is also used to engineer regenerative medicine and stem cells. The advent of new technology has enabled the development of nanofiber scaffolds with the help of nanofabrication techniques. All these recent developments cumulatively boost the regenerative medicine market.

Efficient treatment options are possible with continuous R&D due to the increasing prevalence of cancer. Different public companies and government organizations are making investments for the research and development in regenerative and advanced cell therapies for the treatment of cancer. These global efforts are further expected to propel growth in the regenerative medicine market.

The key vendors in the industry, along with quality control services, engineering, characterization, manufacturing, management, and some other facilities for R&D and clinical trials, are boosting growth in the regenerative medicine market.

Regenerative Medicine Market: Competitive Dynamics and Key Developments

The key industry player companies are making heavy investments to develop regenerative therapies in order to meet clinical demands in the market. The companies are concentrating to introduce therapies for age-related and oncology-related degenerative disorders. Furthermore, the strategic agreements and collaborative efforts for the development of products and technology sharing will create lucrative opportunities in the regenerative medicine market.

A considerable number of market strategies, such as mergers and acquisitions have developed a growth in the regenerative medicine market. Such as, Agilis Biotherapeutics has been acquired by PTC Therapeutics. Astellas has also acquired Quethera & Universal Cells. The arrival of well-established pharmaceutical organizations is expected to increase M&A activities, which will boost growth in the regenerative medicine market.

Get Table of Content of the Report @ https://www.tmrresearch.com/sample/sample?flag=T&rep_id=1889

Some of the key market players in the regenerative medicine market include:

Regenerative Medicine Market: Regional Assessment

North America has dominated in the regenerative medicine market in the past year and is also expecting the same in the upcoming years. It is contributing a larger amount in the market revenue. A large number of industry players in the North American regenerative medicine market are the key reasons for the growth. The research institutes presence and advanced technologies for the development of different therapies are increasing the count of clinical trials in the region, and it further boosts growth in the regenerative medicine market.

Different government initiatives and raising funds from private as well as government bodies are also contributing to the revenue generation in the regenerative medicine market. The increasing facilities and infrastructure is also anticipated to boost growth in the regenerative medicine market in the Asia Pacific region.

About TMR Research

TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in todays supercharged economic climate. Armed with an experienced, dedicated, and dynamic team of analysts, we are redefining the way our clients conduct business by providing them with authoritative and trusted research studies in tune with the latest methodologies and market trends.

Contact:

Rohit Bhisey

TMR Research,

3739 Balboa St # 1097,

San Francisco, CA 94121

United States

Tel: +1-415-520-1050

Visit Site: https://www.tmrresearch.com/

Read more from the original source:
Regenerative Medicine Market Key Players are making Heavy Investments to Develop Regenerative Therapies in order to meet Clinical Demands - BioSpace

PHILADELPHIAToo many exhausted T cells left in the wake of aggressive chemotherapy regimens for patients with advanced chronic lymphocytic leukemia (CLL) make it more challenging for chimeric antigen receptor (CAR) T cell therapy to do its job. Now, a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania shows how to overcome this type of resistance and reinvigorate these T cells with an experimental small molecule inhibitor.

Reporting online today in the Journal of Clinical Investigation, the team shows how the drug, known as JQ1, improved CAR T cell function by inhibiting what is known as the bromodomain and extra terminal (BET) proteins. BET, the researchers showed, can disrupt CAR expression and key acetylated histone functions in T cells in CLL.

The findings demonstrate, for the first time, this mechanism of resistance and present a much-needed target for CLL when treating patients with cellular therapies like CAR. Only a small subset of patients with advanced CLL respond to CAR T cell therapycompared to 80 percent of acute lymphocytic leukemia patients with advanced disease.

Why CAR T cells fail to fully attack cancer cells in so many CLL patients is an important question that needs to be answered in order to expand the use of these immunotherapies in CLL and other cancers, said senior author Joseph A. Fraietta, PhD, an assistant professor of Microbiology at Penn, and member of the Center for Cellular Immunotherapies. Treating these war weary T cells during the CAR T cell engineering process has the potential to boost responses, weve shown here. Its setting the stage for a very promising set of next steps that rationalize further studies, including clinical trials, to prove this approach is safe and feasible.

Using the small molecule inhibitor and the T cells and CD19 CAR T cells from multiple previously treated patients, the researchers demonstrated that the BET protein plays a role in downregulating CAR expression, and that, if blocked, can diminish CAR cell T cell exhaustion and increase the production of CAR T cells from CLL patients with poor lymphocytes.

Treatment with JQ1 also increased levels of various immunoregulatory cytokines and chemokines previously reported to be produced by CAR T cells in CLL during successful therapy. The array of native immune and CAR cells mirrored those found more typically in patients who do respond.

Given this observed reinvigoration of dysfunctional CLL patient CAR T cells by BET inhibition, the authors suggest that incorporating JQ1 into cellular engineering and expansion processes could lead to a generation of less defective and more potent final CAR T cells for patients.

To what extent the above pathways contribute to the effects of JQ1 on CAR T cells is a focus of ongoing investigations for the research group.

This work shows us that T cells can be taught new tricks, said Bruce Levine, PhD, the Barbara and Edward Netter Professor in Cancer Gene Therapy in Penns Perelman School of Medicine, and co-author on the study.That is to say that the methods of manufacturing can be adapted to improve CAR T cell function, so that what would have been exhausted or dysfunctional cells can now be reinvigorated, and potentially lead to better clinical responses in more patients than before.

This work was supported by the Bob Levis Funding Group, along with the National Institute of Allergy and Infectious Diseases (T32 AI007632), National Cancer Institute (P01 CA214278 575, R01 CA241762 U54 CA244711 576, P30 CA016520-44S3, and P30 CA016520-44S4), National Institute on Aging (U01 AG066100), the National Institute of General Medical Sciences (R01 GM118501), an Emerging Cancer Informatics Center of Excellence award from the Penn Institute for Biomedical Informatics and Abramson Cancer Center,Gabrielles Angel Foundation, an Alliance for Cancer Gene Therapy Investigator Award in Cell and Gene Therapy for Cancer, and Novartis.

Editors note: Fraietta is a co-founder of DeCART Therapeutics, Inc. and Levine is a co-founder of Tmunity Therapeutics, Inc. The University of Pennsylvania has licensed certain study-related technologies to Novartis. Penn and the inventors of these technologies receive significant financial benefits as a result of this licensing relationship with Novartis.

Penn Medicineis one of the worlds leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of theRaymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nations first medical school) and theUniversity of Pennsylvania Health System, which together form a $8.9 billion enterprise.

The Perelman School of Medicine has been ranked among the top medical schools in the United States for more than 20 years, according toU.S. News & World Report's survey of research-oriented medical schools. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $496 million awarded in the 2020 fiscal year.

The University of Pennsylvania Health Systems patient care facilities include: the Hospital of the University of Pennsylvania and Penn Presbyterian Medical Centerwhich are recognized as one of the nations top Honor Roll hospitals byU.S. News & World ReportChester County Hospital; Lancaster General Health; Penn Medicine Princeton Health; and Pennsylvania Hospital, the nations first hospital, founded in 1751. Additional facilities and enterprises include Good Shepherd Penn Partners, Penn Medicine at Home, Lancaster Behavioral Health Hospital, and Princeton House Behavioral Health, among others.

Penn Medicine is powered by a talented and dedicated workforce of more than 44,000 people. The organization also has alliances with top community health systems across both Southeastern Pennsylvania and Southern New Jersey, creating more options for patients no matter where they live.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2020, Penn Medicine provided more than $563 million to benefit our community.

Continue reading here:
Existing Drug May Help Improve Responses to Cellular Therapies in Advanced Leukemias - pennmedicine.org

DUBLIN--(BUSINESS WIRE)--The "Global Direct-to-Consumer Genetic Testing Market: Focus on Direct-to-Consumer Genetic Testing Market by Product Type, Distribution Channel, 15 Countries Mapping, and Competitive Landscape - Analysis and Forecast, 2021-2031" report has been added to ResearchAndMarkets.com's offering.

Direct-to-consumer genetic testing market to be one of the growing markets, which is predicted to grow at a CAGR of 17.30% during the forecast period, 2021-2031.

The direct-to-consumer genetic testing market's growth has been primarily attributed to the major drivers in this market, such as the growing amount of direct-to-consumer genetic testing, increasing research funding in the field of molecular biology, and an increase in awareness and acceptance of personalized medicine on a global level.

However, genomic data protection, ethical and social issues, and lack of regulatory standards are some of the factors expected to restrain the market growth.

Market Overview

Decreased cost and time required for genetic sequencing have increased the acceptance of DTC genetic testing among consumers. DTC genetic testing companies offer these genetic tests to their consumers through online channels and over-the-counter (OTC) channels, which has made these tests easily accessible to consumers around the globe.

The market is favored by the increased research activities based on next-generation sequencing-based technologies. The technology has been segmented into targeted analysis, whole genome sequencing, and single nucleotide polymorphisms. The whole genome sequencing segment is expected to grow at the highest CAGR of 17.37% during the forecast period 2021-2031.

This increase is mainly attributed to a large number of research and development being conducted due to the COVID-19 pandemic and regulatory approvals gained by key companies for genetic health risks-based tests.

Within the research report, the market is segmented on the basis of product type, technology, distribution channel, and region. Each segment covers the snapshot of the market over the projected years, the inclination of the market revenue, underlying patterns, and trends by using analytics on the primary and secondary data obtained.

Competitive Landscape

With the increasing consumer awareness and intense market penetration, companies such as 23andme, Inc., Ancestry.com, LLC, and Color Genomics have become pioneers and significant competitors in this market.

Other key players in the market are 24Genetics, Easy DNA, DNAfit, and My Heritage Ltd., among others.

The increased demand for complex and custom sequencing techniques, rising genetic testing services, and growing research to treat and diagnose genetic and infectious diseases have opened opportunities for companies to expand their product portfolios, increase automation facilitation, and develop novel consumer genetics solutions by adopting different strategic approaches.

Some of the strategies followed by the contributors are new product launches and enhancements, agreements, collaborations, partnerships, acquisitions, and expansions. For instance, in 2020, Eastern Biotech & Life Sciences launched Genoplan, which offers advanced genetic tests analyzing hundreds of medical, health, and well-being categories.

As the industry is new and currently unregulated, skepticism arises among government organizations and customers about the validity of the test results. Despite the good acceptance in some countries, few countries still require genetic counseling to be part of their mainstream genetic tests.

Companies can collaborate with physicians and genetic counselors to analyze the genetic test results or to pre-test counseling to the customers. This could also lead to opening a new distribution channel of the market, therefore increasing the sales of these genetic tests.

The direct-to-consumer genetic testing market has been widely accepted in North America and some regions of Europe, such as the U.K. as well as in few parts of Asia-Pacific. Companies exploring regions such as the U.A.E, China, South Korea, and EU5 can open many business opportunities. Established players as well as new entrants should be focusing on shaping the regulatory landscape for the different countries and paving the way for entry into the regulated market, thus gaining the confidence of the consumers. Expanding globally will result in the explosion of the market.

Furthermore, established key players in the market should work with governments to organize education and awareness programs for consumers and genetic counselors for effective interpretation of results, providing consumers a sense of empowerment, which will certainly help the growth of the market.

Due to the limited awareness among consumers and training among primary physicians or genetic counselors, there are high chances of misinterpretation of results and inappropriate test utilization. Professional support to the consumers will help the consumers to understand better about the outcomes and transform the reach of healthcare to the consumers.

Key Questions Answered in this Report

Market Growth Drivers

Market Challenges

Market Opportunities

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/gi0d9z

See the original post:
Global Direct-to-Consumer Genetic Testing Market Analysis and Forecast, 2021-2031 Featuring Market pioneers - 23andme, Ancestry.com, and Color...

Global Direct-to-Consumer Genetic Testing Market to Reach $6,604. 5 Million by 2031. Market Report Coverage - Direct-to-Consumer Genetic Testing Market Segmentation.

New York, Aug. 19, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Global Direct-to-Consumer Genetic Testing Market: Focus on Direct-to-Consumer Genetic Testing Market by Product Type, Distribution Channel, 15 Countries Mapping, and Competitive Landscape - Analysis and Forecast, 2021-2031" - https://www.reportlinker.com/p06129776/?utm_source=GNW

Product Type- Ancestry, Health and Wellness, and Entertainment Technology Targeted Analysis, Single Nucleotide Polymorphisms (SNPs), and Whole Genome Sequencing (WGS) Distribution Channel- Online Channel and Over-the-Counter Channel

Regional Segmentation

North America U.S., Canada Europe Germany, France, Italy, U.K., Spain, and Rest-of-Europe Asia-Pacific China, Japan, Australia, India, and South Korea Latin America Brazil, Mexico, and Rest-of-the-Latin America Rest-of-the-World

Market Growth Drivers

Growing Number of Direct-to-Consumer Genetic Tests Decreasing Cost of Sequencing Increasing Research Funding in the Field of Molecular Biology Increase in Awareness and Acceptance of Personalized Medicines on a Global Level

Market Challenges

Genomic Data Protection Uncertain Regulatory Standards for Direct-to-Consumer Genetic Tests Ethical and Social Issues

Market Opportunities

Massive Scope for Adoption of Genomic-Based Medicine in Emerging Nations Capitalizing on the High Prevalence of Genetic Disorders Growth in Emerging Nations

Key Companies Profiled

23andme Inc., 24Genetics, Ancestry.com LLC, Atlas Biomed, Color Genomics, DNAfit, Gene by Gene, Chengdu Twenty-Three Rubiks Cube Biotechnology Co., Ltd., EasyDNA, Mapmygenome, MyHeritage Ltd., Laboratory Corporation of America Holdings, Myriad Genetics, Inc., Konica Minolta, Inc., XCODE Life

Key Questions Answered in this Report: What are the major market drivers, challenges, and opportunities in the global direct-to-consumer genetic testing market? What are the key development strategies implemented by the major players in order to sustain in the competitive market? Which is the dominant product type developed by the leading and emerging of direct-to-consumer genetic testing market? What are the key technologies that have been used by leading players in the global market for the development of consumer genetic tests? How is each segment of the market expected to grow during the forecast period 2021-2031? The segments are: o product type o technologyo distribution channelo geography Which companies are anticipated to be highly disruptive in the future, and why? What are the regulations for the development of direct-to-consumer genetic testing?

Market Overview

BIS Research healthcare experts have found the direct-to-consumer genetic testing market to be one of the growing markets, which is predicted to grow at a CAGR of 17.30% during the forecast period, 2021-2031. The direct-to-consumer genetic testing markets growth has been primarily attributed to the major drivers in this market, such as growing number of direct-to-consumer genetic testing, increasing research funding in the field of molecular biology, and increase in awareness and acceptance of personalized medicine on a global level. However, genomic data protection, ethical and social issues, and lack of regulatory standards are some of the factors expected to restrain the market growth.

Decreased cost and time required for genetic sequencing has increased the acceptance of DTC genetic testing among the consumers. DTC genetic testing companies offer these genetic tests to their consumers through online channels and over-the-counter (OTC) channels, which has made these tests easily accessible to consumers around the globe.

The market is favored by the increased research activities based on next-generation sequencing-based technologies.The technology has been segmented into targeted analysis, whole genome sequencing, and single nucleotide polymorphisms.

The whole genome sequencing segment is expected to grow at the highest CAGR of 17.37% during the forecast period 2021-2031. This increase is mainly attributed to a large number of research and development being conducted due to the COVID-19 pandemic and regulatory approvals gained by key companies for genetic health risks-based tests.

Within the research report, the market is segmented on the basis of product type, technology, distribution channel, and region. Each segment covers the snapshot of the market over the projected years, the inclination of the market revenue, underlying patterns, and trends by using analytics on the primary and secondary data obtained.

Competitive Landscape

With the increasing consumer awareness and intense market penetration, companies such as 23andme, Inc., Ancestry.com, LLC, and Color Genomics have become pioneers and significant competitors in this market.

Other key players in the market are 24Genetics, Easy DNA, DNAfit, and My Heritage Ltd., among others.

The increased demand for complex and custom sequencing techniques, rising genetic testing services, and growing research to treat and diagnose genetic and infectious diseases have opened opportunities for companies to expand their product portfolios, increase automation facilitation, and develop novel consumer genetics solutions by adopting different strategic approaches.Some of the strategies followed by the contributors are new product launches and enhancements, agreements, collaborations, partnerships, acquisitions, and expansions.

For instance, in 2020, Eastern Biotech & Life Sciences launched Genoplan, which offers advanced genetic tests analyzing hundreds of medical, health, and well-being categories.

As the industry is new and currently unregulated, skepticism arises among government organizations and customers about the validity of the test results.Despite the good acceptance in some countries, few countries still require genetic counseling to be part of their mainstream genetic tests.

Companies can collaborate with physicians and genetic counselors to analyze the genetic test results or to pre-test counseling to the customers. This could also lead to opening a new distribution channel of the market, therefore increasing the sales of these genetic tests.

The direct-to-consumer genetic testing market has been widely accepted in North America and some regions of Europe, such as the U.K. as well as in few parts of Asia-Pacific. Companies exploring regions such as the U.A.E, China, South Korea, and EU5 can open many business opportunities. Establishes players as well as new entrants should be focusing on shaping the regulatory landscape for the different countries and paving the way for entry into the regulated market, thus gaining the confidence of the consumers. Expanding globally will result in the explosion of the market.

Furthermore, established key players in the market should work with governments to organize education and awareness programs for consumers and genetic counselors for effective interpretation of results, providing consumers a sense of empowerment, which will certainly help the growth of the market.Due to the limited awareness among consumers and training among primary physicians or genetic counselors, there are high chances of misinterpretation of results and inappropriate test utilization.

Professional support to the consumers will help the consumers to understand better about the outcomes and transform the reach of healthcare to the consumers.

Countries Covered North America U.S. Canada Europe Germany Italy France Spain U.K. Asia-Pacific China Japan India Australia South Korea Latin America Brazil Mexico Rest-of-Latin-America Rest-of-the-WorldRead the full report: https://www.reportlinker.com/p06129776/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

__________________________

Story continues

More:
Global Direct-to-Consumer Genetic Testing Market: Focus on Direct-to-Consumer Genetic Testing Market by Product Type, Distribution Channel, 15...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Vigil Neuroscience, a biotechnology company harnessing the power of microglia for the treatment of neurodegenerative diseases, today announced the completion of a $90 million Series B financing to further advance Vigils proprietary pipeline of microglia-targeted medicines for the treatment of neurodegeneration. The financing was led by Vida Ventures with participation from existing investors Atlas Venture, Northpond Ventures and Hatteras Venture Partners as well as new investors including Surveyor Capital (a Citadel company), Cormorant Asset Management, Invus, OrbiMed, Rock Springs Capital, Deep Track Capital, Logos Capital, Pivotal bioVenture Partners, and Lightstone Ventures.

Vigil is developing both a fully human monoclonal antibody, VGL101, and small molecule agonists of triggering receptor on myeloid cells 2 (TREM2), an essential microglia sensor that mediates responses to environmental signals to maintain brain homeostasis. TREM2 is a compelling molecular target for neurodegeneration as it serves as a damage sensor of microglia with trophic function and plays a role in microglia response to CNS injury. The company expects to initiate a Phase 1 study to evaluate VGL101 in healthy volunteers on safety, pharmacokinetics and pharmacodynamics by year end 2021.

The first indication for VGL101 will be adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), a rare inherited neurodegenerative disease caused by a mutation to the CSF1R gene for which there are no therapies currently approved by the FDA. VGL101 has the potential to address an estimated 10,000 people in the United States, with similar prevalence in Europe and Japan, living with this devastating disease. Microglia dysfunction is central to ALSP pathogenesis and Vigil believes TREM2 agonism with VGL101 can restore microglia function, thereby potentially providing therapeutic benefits to patients with the disease. ALSP represents the first indication in Vigils precision medicine strategy of applying learnings from rare indications with strong genetic, biochemical and pathophysiological associations to microglial deficiency to the development of microglia-based therapeutics in more common indications such as Alzheimers Disease. The company is planning to initiate a natural history study enrolling ALSP patients this fall to better understand disease characteristics and evaluate fluid and imaging biomarkers.

ALSP is a devastating disease that has a strong genetic link to microglia dysfunction and signaling deficiency. We plan to work closely with patients and their families to unravel the complexities of the disease and rapidly advance VGL101 through the clinic, said Ivana Magovevi-Liebisch, PhD, JD, President and Chief Executive Officer of Vigil. This financing will enable us to accelerate both our lead TREM2 activating monoclonal antibody in patients as well as advance our small molecule program through important milestones. The remarkable progress our team has made is a testament to our commitment to creating a better tomorrow for patients with neurodegenerative diseases. I applaud their efforts.

Vigil is also performing lead optimization in its small molecule program to develop novel first-in-class agonists of human TREM2 with a compelling profile of potency, solubility, oral bioavailability and CNS uptake. The company plans to apply learnings from its precision-based approach to the development of small molecule TREM2 agonists for more common neurodegenerative diseases such as Alzheimers Disease for which oral administration and high CNS penetrance can meaningfully impact disease treatment.

In conjunction with the closing of the financing, Stefan Vitorovic, Co-founder and Managing Director of Vida Ventures, will join the Vigil Board of Directors. We are delighted to lead this financing with an outstanding group of investors and world-class team. Our research has led us to conclude that there is substantial biological evidence to suggest that restoring the function of microglia plays a key role in arresting neurodegeneration, commented Mr. Vitorovic. Vigil is at the forefront of pioneering such innovative treatments, and I am excited about the potential of their novel precision medicine-based strategy to rapidly bring impactful medicines to patients.

We look forward to working with both the team from Vida as well as all our new and existing investors as we continue to build Vigil into a leading precision medicine company focused on microglia, said Bruce Booth, DPhil, Chairman of the Board of Vigil. We are fortunate to have these leading investors supporting our efforts, and we welcome Stefan to our Board.

About ALSP

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a rare, inherited, autosomal dominant neurological disease with high penetrance. It is caused by a mutation to the CSF1R gene and affects an estimated 10,000 people in the US, with about 1,000 new cases annually. The disease generally presents itself in the fourth decade of life, is diagnosed through genetic testing and established clinical/radiologic criteria and is characterized by cognitive dysfunction, neuropsychiatric symptoms, and motor impairment. These symptoms typically exhibit rapid progression with a life expectancy of approximately 7 years on average after diagnosis, causing significant patient and caregiver burden. There are currently no approved products for the treatment of ALSP, underlining the high unmet need in this rare indication. Patients and caregivers can find more information on ALSP at http://www.alspinfo.com.

About Vigil Neuroscience

Vigil Neuroscience is a microglia-focused therapeutics company treating both rare and common neurodegenerative diseases by restoring the vigilance of microglia, the sentinel cells of the brains immune system. We are utilizing the tools of modern neuroscience drug development across multiple therapeutic modalities to rapidly deliver precision-based therapies to improve the lives of patients and their families. http://www.vigilneuro.com

Read the original post:
Vigil Neuroscience Completes $90 million Series B Financing to Advance a Pipeline of Microglia-targeted Medicines to Treat Rare and Common...

Newswise DALLAS Aug. 19, 2021 A gene calledNpas4, already known to play a key role in balancing excitatory and inhibitory inputs in brain cells, appears to also be a master timekeeper for the brains circadian clock, new research led by UT Southwestern scientists suggests. Thefinding, published online today inNeuron, broadens understanding of the circadian clocks molecular mechanisms, which could eventually lead to new treatments for managing challenges such as jet lag, shift work, and sleep disorders.

To reset the circadian clock, you ultimately need to reset its molecular gears, said study leaderJoseph S. Takahashi, Ph.D.,Professor and Chair of Neuroscience at UTSW and a Howard Hughes Medical Institute Investigator. This study suggests thatNpas4might be one of the most important components for resetting the clock to light.

For decades, researchers have known that a brain region called the suprachiasmatic nucleus (SCN) is responsible for controlling circadian rhythms, the various cycles of activity that typically run on a 24-hour basis. These rhythms are entrained by light, Dr. Takahashi explained; cells in the SCN respond to signals relayed by the retina, the eyes light-sensitive tissue. However, the molecular basis of this phenomenon is not well understood.

To better understand how the SCN sets circadian rhythms, the researchers used a technique called single-nucleus sequencing to look at gene activity in individual cells in mice after the animals were exposed to light. Dr. Takahashi and his colleagues found that three different subpopulations of SCN neurons respond to light stimulation. A common thread tying these subtypes together was increased activity in genes that respond to neuronal PAS domain protein 4 (NPAS4), the protein made by theNpas4gene.

When Dr. Takahashi and his colleagues exposed mice engineered to lackNpas4to light, it dampened the response of hundreds of circadian clock genes. In addition, the animals circadian period lengthened about an extra hour, to nearly 25 hours instead of the normal 24. Together, these results suggest thatNpas4is a master regulator of many light-induced genes, a key piece in the puzzle of how the circadian system works, Dr. Takahashi said.

The more researchers learn about the molecular underpinnings of the circadian clock, Dr. Takahashi added, the more they may be able to manipulate it to improve health and well-being for example, to ease jet lag or help shift workers stay awake or asleep to match their work cycles. It could also lead to new treatments for disorders marked by abnormal sleep/wake cycles.

Other researchers who contributed to this research include Pin Xu, Stefano Berto, Ashwinikumar Kulkarni, Byeongha Jeong, Chryshanthi Joseph, Kimberly H. Cox, Tae-Kyung Kim, all of UT Southwestern; and Michael E. Greenberg of Harvard Medical School.

Dr. Takahashi holds the Loyd B. Sands Distinguished Chair in Neuroscience at UTSW. This work was a collaboration with thelaboratoryofGenevieve Konopka, Ph.D., Associate Professor of Neuroscience, the Jon Heighten Scholar in Autism Research, and Director of the UTSW Neurogenomics Core.Drs. Takahashi and Konopka are members of the Peter ODonnell Jr. Brain Institute.Dr. Kim, a Distinguished Scholar in Neuroscience, is also a member of the ODonnell Brain Institute.

This research was supported by grants from the National Institutes of Health (NS106657, DC014702, MH102603, NS028829), the Howard Hughes Medical Institute, the James S. McDonnell Foundation 21st Century Science Initiative in Understanding Human Cognition Scholar Award (220020467), and the Chan Zuckerberg Initiative, an advised fund of Silicon Valley Community Foundation (HCA-A-1704-01747).

About UTSouthwestern Medical Center

UTSouthwestern, one of the nations premier academic medical centers, integrates pioneering biomedical research with exceptional clinical care and education. The institutions faculty has received six Nobel Prizes, and includes 25 members of the National Academy of Sciences, 16 members of the National Academy of Medicine, and 13 Howard Hughes Medical Institute Investigators. The full-time faculty of more than 2,800 is responsible for groundbreaking medical advances and is committed to Southwestern physicians provide care in about 80 specialties to more than 117,000 hospitalized patients, more than 360,000 emergency room cases, and oversee nearly 3 million outpatient visits a year.

Original post:
A Master Gear in The Circadian Clock - Newswise

Several years ago, researchers at Massachusetts General Hospital (MGH) figured out a way to convert skin cells into muscle cells that were self-renewing and seemed promising for treating injuries and degenerative diseases like muscular dystrophy. But they werent quite sure how the conversion was happening.

Now they knowand they believe their insights could yield recipes for generating patient-matched muscle cells to treat a range of disorders.

The MGH researchers call their muscle cells myogenic progenitor cells (iMPCs). In a new study, published in the journal Genes & Development, they explain how adding three chemicals to skin cells causes them to transform into iMPCs.

A gene called MyoD can convert skin cells into muscle cells, but mature muscle cells cannot divide to create new muscle. In previous experiments, the researchers hit on three chemicals that could make skin cells revert to a stem-cell-like state instead, which would allow them to transform into self-renewing muscle cells.

The key, the MGH researchers discovered in the new study, is that the chemicals remove marks called methyl groups that are added to DNA in a process known as DNA methylation.

DNA methylation typically maintains the identity of specialized cells, and we showed that its removal is key for acquiring a muscle stem cell identity, said lead author Masaki Yagi, Ph.D., a research fellow at MGH, in a statement.

RELATED: Zebrafish reveal regenerative protein that could inspire new treatments for muscle-wasting diseases and aging

Its the latest study focused on finding new ways to regenerate muscle. Earlier this year, an Australian team reported that a protein called NAMPT could regenerate muscle in zebrafish and mouse models by amplifying a natural healing process in the body that occurs when macrophages migrate to injury sites.

Other research groups have focused on the role of the MyoD protein in healing. A Sanford Burnham Prebys team, for example, discovered that in aging people, old muscle stem cells can trigger a DNA damage response that blocks MyoD and prevents muscle cells from forming.

The MGH scientists believe their findings could be useful beyond muscle regeneration. The three-chemical cocktail could be used to generate stem cells for a variety of tissue types, senior author Konrad Hochedlinger, Ph.D., a principal investigator at the Center for Regenerative Medicine at MGH and a professor of medicine at Harvard Medical School, said.

Read this article:
MGH team shows how injured muscles might be repaired with patients' own skin cells - FierceBiotech