Monthly Archives: June 2021

When will the COVID-19 pandemic end? Experts say it may not – KTVB.com

Posted: June 28, 2021 at 10:03 pm

While the pandemic end, the coronavirus may become an epidemic, with hot spots popping up across the country, health experts say.

BOISE, Idaho Asking when the COVID-19 pandemic will be over may sound like asking "Are we there yet?" during a long drive. Sure, Central District Health and Idaho's other public health districts may have faded into the background during recent weeks but the country and the globe are still technically in a pandemic.

The World Health Organization was the first to announce that the world was in the midst of a pandemic in March of 2020. Sometime in the future, the WHO will be the body to announce when it's officially over.

However, there isn't a set standard to mark the end of the pandemic, either. Healthcare and medical experts point to vaccination rates as a guide to when the COVID-19 pandemic might end. If 75-80% of Americans get vaccinated against the coronavirus, it may soon end.

In Idaho, only 37% of 12 to 64-year-olds are fully vaccinated and 73% of people over the age of 65 are. Nationally, only 54% of Americans are fully vaccinated.

Another possibility that scientists are looking at is that the pandemic may morph into an endemic, meaning there is no end to COVID-19 and it would become much like the seasonal flu, where cases might spike in smaller areas and yearly vaccinations are needed to keep it at bay.

Of the 100 epidemiologists surveyed by "Nature," a scientific journal, 90% of them said the coronavirus will likely become endemic.

Reaching the goal of herd immunity to put an end to the coronavirus pandemic will need a combination of more people getting vaccinated and natural immunity lasting. It will also depend on how the virus mutates.

Join 'The 208' conversation:

Continued here:

When will the COVID-19 pandemic end? Experts say it may not - KTVB.com

Posted in Covid-19 | Comments Off on When will the COVID-19 pandemic end? Experts say it may not – KTVB.com

Robotics Firm AutoStore Is Said to Plan IPO at $10 Billion Value – Bloomberg

Posted: at 10:03 pm

AutoStore is weighing an initial public offering that could value the Norwegian warehouse robotics company at more than $10 billion, according to people familiar with the matter.

The company is working with advisers on the planned listing, which could come as soon as this year, the people said, asking not to be identified discussing confidential information. While the venue for the IPO hasnt been confirmed, AutoStore is leaning toward listing on a European exchange, the people said.

Deliberations are ongoing and no final decisions on the timing and size of an IPO have been made, according to the people.

Founded in 1996, Nedre Vats-based AutoStore provides robots used in the storing and retrieval of goods in warehouses. It specializes in so-called cube storage automation and its technology is deployed at more than 600 sites in 35 countries.

Private equity firm Thomas H. Lee Partners acquired the company in 2019. In April, it sold a 40% stake in AutoStore to SoftBank Group Corp. in a deal that valued the company at $7.7 billion including debt.

Thomas H. Lee will continue to be AutoStores largest shareholder after an IPO, the people said.

A representative for AutoStore didnt immediately respond to a request for comment. A spokesperson for Thomas H. Lee declined to comment. SoftBank couldnt be immediately reached for comment.

E-commerce and related companies have seen a flurry of successful listings in the U.S. this year. Another SoftBank-backed firm, South Koreas Coupang Inc., rose 41% in its trading debut in March. The shares have since given up some of their gains but are still trading about 8% above the offer price.

Companies have raised an all-time high of almost $350 billion via IPOs this year, according to data compiled by Bloomberg, exceeding a previous peak of $282 billion from the second half of 2020.

With assistance by Michael Hytha

Before it's here, it's on the Bloomberg Terminal.

Go here to read the rest:

Robotics Firm AutoStore Is Said to Plan IPO at $10 Billion Value - Bloomberg

Posted in Robotics | Comments Off on Robotics Firm AutoStore Is Said to Plan IPO at $10 Billion Value – Bloomberg

Diabetes Reversal Leader Virta Health Demonstrates Promising Results on Mitigating COVID-19 Severity for People with Type 2 Diabetes – Business Wire

Posted: at 10:03 pm

SAN FRANCISCO--(BUSINESS WIRE)--Virta Health, the leader in type 2 diabetes reversal, today announced promising results on the ability of its treatment to mitigate COVID-19 severity. Presenting abstract data at the American Diabetes Association 2021 Scientific Sessions, the company highlighted low rates of hospitalization, ventilation, and mortality for Virta patients living with type 2 diabetes who also contracted COVID-19.

COVID-19 has created a harrowing set of conditions for people with metabolic disorders. Risk of dying from COVID-19 is twice as high compared to those without diabetes. One study showed that over 50% of COVID hospitalizations were attributed to obesity or type 2 diabetes.

Todays announcement underscores the potential of improved metabolic health to radically improve COVID outcomes. Virta observed low rates of hospitalization (11.2%), ventilation (1.8%), and death (0.3%) relative to national reports. For example, a study in the Vanderbilt University Medical Center reported hospitalization, ventilation, and death rates of 44.3%, 5.9%, and 4.8%, respectively, for people living with type 2 diabetes. Weight loss held the strongest association with reduced COVID-19 severity, while accounting for other variables like age, starting weight, and days receiving nutrition therapy.

By helping patients restore blood sugar to normal levels, eliminate medications, and lose significant weight, Virtas approach directly addresses some of the most important risk factors to minimize the severity of COVID-19 infection.

Beyond vaccination, improved metabolic health is one of the best defenses we have against COVID severity, said Dr. Robert Ratner, Chief Medical Officer of Virta Health.

Although significant COVID vaccination progress has been made nationally, more than half of the U.S population remains unvaccinated. Globally the number is significantly less. COVID variants continue to raise concern among health experts, as new variants have shown increased transmissibility and complication severity.

These conditions continue to demand multi-faceted solutions to minimize the impact of the COVID-19 pandemic both in the United States and abroad. Todays news provides encouraging data on how to do so, while offering critical insight into battling future pandemics where metabolic health plays a central role.

About Virta Health:

Virta Health helps people reverse type 2 diabetes and other chronic conditions. Current approaches manage disease progression through increased medication use and infrequent doctor visits. Virta reverses type 2 diabetes through innovations in technology, nutrition science, and continuous remote care from physicians and behavioral experts. In clinical studies, 94% of patients reduce or eliminate insulin use, and weight-loss exceeds FDA benchmarks by 150%. Virta works with the largest health plans, employers, and government organizations and puts 100% of its fees at risk based on clinical and financial outcomes. To learn more about how Virta is transforming lives by reversing type 2 diabetes and other chronic diseases, visit http://www.virtahealth.com or follow us on Twitter @virtahealth.

Read this article:

Diabetes Reversal Leader Virta Health Demonstrates Promising Results on Mitigating COVID-19 Severity for People with Type 2 Diabetes - Business Wire

Posted in Covid-19 | Comments Off on Diabetes Reversal Leader Virta Health Demonstrates Promising Results on Mitigating COVID-19 Severity for People with Type 2 Diabetes – Business Wire

Dairy Specialists LLC announces acquisition of Priority Robotics of Tillamook Inc. – Tillamook Headlight-Herald

Posted: at 10:03 pm

Dairy Specialists LLC (Dairy Specialists) of Evans, Colo., is pleased to announce it has finalized an agreement to acquire the assets of Priority Robotics of Tillamook Inc. (Priority Robotics), effective July 1. Priority Robotics, which was founded in 2015, specializes in the distribution, installation and service of robotic dairy milking equipment and holds an exclusive territory dealership for Oregon and Washington with Lely North America, the worldwide leader in dairy robotics.

The acquisition of Priority Robotics, located in Tillamook, increases the market share of Dairy Specialists in robotics and broadens the companys geographical reach to better serve the increasingly technological dairy industry. Priority Robotics currently employs six individuals in the Tillamook region, all of whom will remain on staff and continue serving customers under the Priority Robotics of Tillamook Inc. name.

It is an exciting time in the industry, and the acquisition of Priority Robotics fits perfectly into our strategic business model. We are cutting edge when it comes to technology, so adding the talent and resources of Priority Robotics allows us to gain more leverage in the industry, said Brian Stork, chief operations officer at Dairy Specialists.

Kurt Mizee, the founder and owner of Priority Robotics, will serve as an independent consultant to Dairy Specialists. He will assist with integrating the two companies and help transition customers and staff onto the Dairy Specialists platform. He will also continue to own and serve as vice president of Tilla-Bay Farms, Inc., which was the first dairy in the Western United States to install a robotic dairy milking system in 2011.

I feel strongly that Dairy Specialists values and leadership align with the vision and mission of Priority Robotics, said Mizee. This sale provides a greater array of resources to better position the business into the future.

Dairy Specialists LLC, a subsidiary of Ag Property Solutions (www.agpropertysolutions.com) is one of the largest and most innovative commercial dairy service and equipment dealerships in the country. The company supplies commercial dairy farms with innovative parlor designs, new construction, remodels, robotic milkers, dairy waste management and 24/7 tech services. Additionally, the company offers state-of-the-art dairy equipment, parts, and supplies thanks to strategic partnerships with a myriad of the worlds best manufacturers and suppliers. For more information, visit http://www.dairyspecialists.com/.

Priority Robotics of Tillamook Inc. is a dairy robotics dealership established in 2015, by farmers for farmers. The company proudly sells equipment made by Lely of North America. With a business model based on reliability, consistency and efficiency, Priority Robotics is a trusted supplier, contributing to the success of their customers. Along with Lely, Priority Robotics takes customers to the next level in dairy automation.

View original post here:

Dairy Specialists LLC announces acquisition of Priority Robotics of Tillamook Inc. - Tillamook Headlight-Herald

Posted in Robotics | Comments Off on Dairy Specialists LLC announces acquisition of Priority Robotics of Tillamook Inc. – Tillamook Headlight-Herald

Astronomers Are Zeroing In On The Birth Of The First Stars – IFLScience

Posted: at 10:03 pm

When did the first stars start shining? Researchers are now closer than ever to the answer. Work led by scientists in the UK places cosmic dawn between 250 and 350 million years after the Big Bang.The researchers alsobelieve the first galaxies hosting these first stars might soon become observable to our instruments.

The research, published in the Monthly Notices of the Royal Astronomical Society, set out to expand our understanding of one of the most mysterious times of our universe: the cosmic dark ages. For hundreds of millions of years, no (visible) light shone in the cosmos. Slowly but surely, gas began to clump up in large clouds and from these clouds, due to gravitational collapse, the first stars were born.

The team estimated this by looking at six of the furthest galaxies ever discovered. Looking far into the universe is like looking into the past, due to the finiteness of the speed of light. The light of these half-a-dozen objects comes to us from when the Universe was just 550 million years old. They then estimated the age of these galaxies, suggesting when the stars in them were born.

Witnessing the moment when the universe was first bathed in starlight is a major quest in astronomy, lead author Dr Nicolas Laporte, from the University of Cambridge, said in a statement.

Our observations indicate that cosmic dawn occurred between 250 and 350 million years after the beginning of the universe, and, at the time of their formation, galaxies such as the ones we studied would have been sufficiently luminous to be seen with the James Webb Space Telescope.

Thanks to observations from the Hubble and Spitzer space telescopes, the team was able to estimate the presence of atomic hydrogen. During the cosmic dark ages, all hydrogen was atomic hydrogen, but the light of stars ripped the electrons from those hydrogen atoms (a process called ionization). By the end of cosmic dawn, the vast majority of hydrogen in the universe was once again ionized.

This fact is important by estimating how much hydrogen is left to be ionized in a galaxy, you can work out how long its stars have been active. It is a good way to date the formation of these objects and their stars.

This age indicator is used to date stars in our own neighbourhood in the Milky Way but it can also be used to date extremely remote galaxies, seen at a very early period of the universe, added co-author Dr Romain Meyer, from University College London and the Max Planck Institute for Astronomy in Heidelberg, Germany.

Using this indicator we can infer that, even at these early times, our galaxies are between 200 and 300 million years old.

The light of the first galaxies might soon be in our grasp (and telescopes).

Receive our biggest science stories to your inbox weekly!

Read this article:

Astronomers Are Zeroing In On The Birth Of The First Stars - IFLScience

Posted in Astronomy | Comments Off on Astronomers Are Zeroing In On The Birth Of The First Stars – IFLScience

The Largest Comet Ever Found Is Making Its Move Into a Sky Near You – The New York Times

Posted: at 10:03 pm

Astronomers spy rocky and icy wanderers of all shapes and sizes zipping past Earth all the time. But earlier this month, they were flabbergasted when they caught sight of the largest comet theyd ever seen.

One of its discoverers, Pedro Bernardinelli, an astrophysicist at the University of Pennsylvania, conservatively estimates the objects dusty, icy nucleus is between 62 and 125 miles long. That means this comet is as small as five Manhattan Islands, or its larger than the Island of Hawaii. Hale-Bopp, which lit up night skies in the late 1990s with its 25-mile-long nucleus, was long perceived to be a giant among comets. But the nucleus of this comet, Comet C/2014 UN271, is still two or three Hale-Bopps across, said Teddy Kareta, a planetary astronomy graduate student at the University of Arizona. Its just wild.

With a reasonable degree of certainty, its the biggest comet that weve ever seen, said Colin Snodgrass, an astronomer at the University of Edinburgh.

The comet is currently inside Neptunes orbit. Over the next decade, it will scoot toward the inner solar system. More of its ices will be vaporized by the suns glare, causing it to effervesce and brighten. In 2031, it will get within a billion miles of the sun almost but not quite making it to Saturn before journeying back to the coldest, darkest fringes of our galactic neighborhood.

Although its unlikely a spacecraft will be able to rendezvous with the comet, spotting it while its still two billion miles away means that astronomers can train their telescopes on it and watch it flare, then fade, in staggering detail over the next 20 years.

Comets are like cats. You never know what theyre going to do, said Meg Schwamb, an astronomer at Queens University Belfast. Im ready to get the popcorn.

Comets are icy remnants as old as the sun, and may have delivered both water and organic matter to the solar systems rocky worlds. This frosty leviathan, then, is a fantastic opportunity to uncover a bounty of cometary secrets.

It was first spotted with the Dark Energy Survey, an effort to map distant galaxies and exploding stars in order to investigate the universes accelerating expansion. To galaxy hunters, all those rocks in the foreground are just a nuisance, Dr. Snodgrass said. But to comet chasers, theyre quite an interesting nuisance.

A search of the surveys databanks found over 800 novel iceballs with orbits larger than Neptunes. One, designated 2014 UN271, was by far the most interesting one we found, Dr. Bernardinelli said.

A series of images of the icy object captured from 2014 to 2018 revealed it was definitely icy, probably elongated, and had emerged from the Oort cloud, an expansive shell of primordial space debris surrounding the solar system nothing unusual so far. But when its dramatic dimensions were announced on June 19, scientists were blown away. Its not even close to being the largest object beyond Neptune. But its sunward trajectory meant that, if its ices transmogrified into gases, it would become the largest comet ever found.

Their curiosities piqued, Dr. Snodgrass, Dr. Schwamb and their colleagues used telescopes in South Africa and Namibia to take a closer look and they spied a coma, an envelope of gas, surrounding it. Despite its considerable distance, some of its more volatile ices carbon dioxide and carbon monoxide, perhaps were already being vaporized by slivers of sunlight.

It was official: This was a colossal comet. On June 24, this newly identified gadabout was renamed Comet C/2014 UN271 (Bernardinelli-Bernstein) after its discoverers Dr. Bernardinelli and Gary Bernstein, an astronomer at the University of Pennsylvania.

This comet takes roughly three million years to make one complete circumnavigation of the sun. The last time it was here, modern humans had yet to evolve. The next time it comes around, who can say what will have come of our species. This may be the only chance humanity will get to glimpse it.

In 2031, if you take a halfway-decent telescope to a dimly lit area, you will be able to see this specter shift among the stars. At a distance of one billion miles, it wont provide the cinematic streak some comets are famous for, but you will see a flicker of light.

Many of the night skys flickers belong to unfathomably distant objects. But not comets and, like all its icy cousins, this one is both weird and beautiful, Mr. Kareta said. Its visitation reminds us that the universe isnt a static expanse, but a chaotic ballet, full of wondrous things always in motion.

Read the original post:

The Largest Comet Ever Found Is Making Its Move Into a Sky Near You - The New York Times

Posted in Astronomy | Comments Off on The Largest Comet Ever Found Is Making Its Move Into a Sky Near You – The New York Times

Eager to Go Overseas This Summer? A Covid-19 Vaccine Will Help – The Wall Street Journal

Posted: at 10:03 pm

Governments around the world are trying to capitalize on rising Covid-19 vaccination rates to kick-start international travel again, but officials and travel-industry executives are clashing over how.

The European Union is slated to roll out a digital health certificate this weekallowing vaccinated residents to travel restriction-free across the bloc. Canada and the U.K., meanwhile, have said residents can travel overseas again without having to quarantine on their returnas long as they are fully vaccinated. South Korea has said it would allow vaccinated visitors into the country without quarantine restrictions, and Ecuador has dropped testing requirements for vaccinated visitors.

Industry executives complain that the vaccine-related easings arent being coordinated adequately and are being rolled out too slowly.

Its really confusing and thats part of the challenge, Virginia Messina, senior vice president at the World Travel & Tourism Council, said. Its understanding what the rules are in the country youre going to and then what the rules are when you return.

Meanwhile, the so-called Delta variant, first identified in India, has sent Covid-19 cases rising again in countries that not too long ago seemed to have the virus under control. That has governments reconsidering earlier plans to lift travel restrictions. On Monday, Hong Kong banned travelers from the U.K., citing the variant.

Read the original:

Eager to Go Overseas This Summer? A Covid-19 Vaccine Will Help - The Wall Street Journal

Posted in Covid-19 | Comments Off on Eager to Go Overseas This Summer? A Covid-19 Vaccine Will Help – The Wall Street Journal

Insights on the Automotive Robotics Global Market to 2026 – Featuring ABB, Omron Adept Robotics and Honda Motor Among Others – ResearchAndMarkets.com…

Posted: at 10:03 pm

DUBLIN--(BUSINESS WIRE)--The "Automotive Robotics Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)" report has been added to ResearchAndMarkets.com's offering.

The automotive robotics market iwas valued at USD 9 billion in 2020 and is anticipated to reach USD 16 billion by 2026, at a CAGR of over 10% during the forecast period (2021 - 2026).

Companies Mentioned

Key Market Trends

Technological innovations are driving the market growth

The automotive manufacturing segment has been taking rapid steps in the industrial automation domain emerging as a role model for the other industries by showcasing how automation should be utilized to scale up the value chain and achieve zero-defects manufacturing. The automotive industry has been an early adopter of robotics for applications, like welding, painting, glue dispensing, etc. However, there are plenty of robotic applications available to choose from within the industry.

Now, the automotive industry is shifting its focus toward the new technology trends, like compact robot and controller, higher communication speed, low spatter, and high-speed welding, human collaborative robot with industry 4.0.

Now with all application automobile company moving toward Internet of Things (IoT). Growth in the IoT concept and technological advances have boosted the use of automated technologies in various industries. The high penetration rate of smart devices and the use of wireless and cloud technologies will change the face and mode of operation of robots in the near future.

Asia-Pacific is Expected to Lead the Automotive Robotics Market

Asia-Pacific is the fastest developing region globally, with countries, like India, China, Taiwan, and South Korea evolving as the leaders in this region. Leading vendors, such as ABB and KUKA are instituting the region as their operation's base. Furthermore, government regulations and funds have empowered projects to improve the infrastructure. These aspects have made APAC the favored automotive manufacturing hub, which will drive the automotive robotics market.

Countries, such as China and India are the principal countries in Asia-Pacific in terms of development, and many industries, such as automotive, electronics, and aviation are opening their factories in these countries, which is generating the demand for the automotive robotics market, making Asia-Pacific an emerging region.

Major players in the region are adopting robotics and other advance manufacturing technology for their upcoming vehicles. For instance, in January 2021, Byton has signed a manufacturing deal with Foxconn, which will be providing advanced manufacturing technology, operation management expertise and supply chain resources to Byton. The two companies will work together for Byton's M-Byte electric SUV across all stages of its production line for introducing the SUV in Chinese market by 2022.

Morover, Byton Nanjing factory was built to industry 4.0 standards using leading manufacturing equipment and technology. The welding shop comprise of 335 welding robots by Kuka.

Key Topics Covered:

1 INTRODUCTION

2 RESEARCH METHODOLOGY

3 EXECUTIVE SUMMARY

4 MARKET DYNAMICS

4.1 Market Drivers

4.2 Market Restraints

4.3 Industry Attractiveness - Porter's Five Forces Analysis

5 MARKET SEGMENTATION

5.1 By End-user Type

5.2 Component Type

5.3 By Product Type

5.5 Geography

6 COMPETITIVE LANDSCAPE

7 MARKET OPPORTUNITIES AND FUTURE TRENDS

For more information about this report visit https://www.researchandmarkets.com/r/23vrn1

Read more:

Insights on the Automotive Robotics Global Market to 2026 - Featuring ABB, Omron Adept Robotics and Honda Motor Among Others - ResearchAndMarkets.com...

Posted in Robotics | Comments Off on Insights on the Automotive Robotics Global Market to 2026 – Featuring ABB, Omron Adept Robotics and Honda Motor Among Others – ResearchAndMarkets.com…

Spot the difference: Viruses making a comeback post-pandemic, but is it COVID-19? – KXAN.com

Posted: at 10:03 pm

`;// articleContent = document.querySelector(".article-content");// articleContent.innerHTML = articleContent.innerHTML + formbox;let firstParagraph = document.querySelector("div.article-content > p:nth-child(1)");if (firstParagraph !== null) {firstParagraph.insertAdjacentHTML("afterend", formbox);}function waitForElement(id, callback){var goStahp = setInterval(function(){if(document.getElementById(id)){clearInterval(goStahp);callback();}}, 100);}waitForElement("JotFormIFrame-202185815209151", function(){const expandButton = document.querySelector('h3.expand_box_click_to_open_covid_form');expandButton.addEventListener('click', function() {let box = document.querySelector('.corona_form_expand_box_covid_form');let first = 'opening';let second = 'open';let buttonAction = 'Hide story tip submission form';let deviceAction = "Tap";if (window.innerWidth > 666) {deviceAction = "Click";}// console.log(window.innerWidth);if(box.classList.contains(first)) {[first, second] = [second, first];buttonAction = `${deviceAction} to submit a coronavirus story tip`;}expandButton.innerHTML = buttonAction;box.classList.toggle(first);setTimeout(() => {box.classList.toggle(second);}, 0);});var ifr = document.getElementById("JotFormIFrame-202185815209151");if(window.location.href && window.location.href.indexOf("?") > -1) {var get = window.location.href.substr(window.location.href.indexOf("?") + 1);if(ifr && get.length > 0) {var src = ifr.src;src = src.indexOf("?") > -1 ? src + "&" + get : src + "?" + get;ifr.src = src;}}window.handleIFrameMessage = function(e) {if (typeof e.data === 'object') { return; }var args = e.data.split(":");if (args.length > 2) { iframe = document.getElementById("JotFormIFrame-" + args[(args.length - 1)]); } else { iframe = document.getElementById("JotFormIFrame"); }if (!iframe) { return; }switch (args[0]) {case "scrollIntoView":iframe.scrollIntoView();break;case "setHeight":console.log(`case: setHeight`);iframe.style.height = parseInt(args[1]) + 15 + "px";break;case "collapseErrorPage":console.log(`case: collapseErrorPage`);if (iframe.clientHeight > window.innerHeight) {iframe.style.height = window.innerHeight + "px";}break;case "reloadPage":window.location.reload();break;case "loadScript":var src = args[1];if (args.length > 3) {src = args[1] + ':' + args[2];}var script = document.createElement('script');script.src = src;script.type = 'text/javascript';document.body.appendChild(script);break;case "exitFullscreen":if (window.document.exitFullscreen) window.document.exitFullscreen();else if (window.document.mozCancelFullScreen) window.document.mozCancelFullScreen();else if (window.document.mozCancelFullscreen) window.document.mozCancelFullScreen();else if (window.document.webkitExitFullscreen) window.document.webkitExitFullscreen();else if (window.document.msExitFullscreen) window.document.msExitFullscreen();break;}var isJotForm = (e.origin.indexOf("jotform") > -1) ? true : false;if(isJotForm && "contentWindow" in iframe && "postMessage" in iframe.contentWindow) {var urls = {"docurl":encodeURIComponent(document.URL),"referrer":encodeURIComponent(document.referrer)};iframe.contentWindow.postMessage(JSON.stringify({"type":"urls","value":urls}), "*");}};if (window.addEventListener) {window.addEventListener("message", handleIFrameMessage, false);} else if (window.attachEvent) {window.attachEvent("onmessage", handleIFrameMessage);}});//

Read more here:

Spot the difference: Viruses making a comeback post-pandemic, but is it COVID-19? - KXAN.com

Posted in Covid-19 | Comments Off on Spot the difference: Viruses making a comeback post-pandemic, but is it COVID-19? – KXAN.com

Dapaglifozin Found to be Well-Tolerated in Hospitalized Patients With COVID-19 – Pharmacy Times

Posted: at 10:03 pm

The DARE-19 clinical trial explores the use of SGLT2 inhibitors for patients with hypertension, cardiovascular disease, heart failure, type 2 diabetes, or chronic kidney disease, and COVID-19.

A recent study found that dapagliflozin (Farxiga; AstraZeneca), a sodium-glucose cotransporter-2 (SGLT2) inhibitor, was well-tolerated in hospitalized patients with COVID-19, and participating patients had fewer serious adverse events than those taking placebo. Results of the DARE-19 trial (NCT04350593) were presented Sunday during the virtual 81st Scientific Sessions of the American Diabetes Association (ADA).1

According to the ADA, DARE-19 is the first large randomized clinical trial to assess SGLT2 inhibitors, a medication class initially used to help lower blood glucose, in patients with and without type 2 diabetes who are hospitalized with COVID-19. Funded by AstraZeneca, the study found that treatment with dapagliflozin did not achieve statistically significant reduction in organ failure or death, nor did it significantly improve clinical recovery, compared with placebo. However, fewer patients treated with dapagliflozin experienced organ failure or death compared to placebo (11.2% vs 13.8%, respectively).1

Previously, there were some concerns with using SGLT2 inhibitors in COVID-19 patients due to the potential risk for acute kidney injury and diabetic ketoacidosis. However, our results show dapagliflozin is well tolerated, with no new safety concerns, said the studys lead investigator Mikhail Kosiborod, cardiologist and vice president for research at Saint Luke's Health System; and professor of medicine, University of Missouri-Kansas City, in a press release. We believe that our findings do not support routine discontinuation of SGLT2 inhibitors in patients hospitalized with COVID-19 that have other indications for these agents, such as type 2 diabetes, heart failure and chronic kidney disease (CKD), as long as patients are monitored.

Patients with cardiometabolic risk factors, including type 2 diabetes, are at higher risk for developing serious COVID-19-related complications, such as organ failure and death. According to the ADA, Americans with diabetes and other related underlying health conditions are hospitalized 6 times more often and are 12 times more likely to die of COVID-19 than those without diabetes. Previous studies have shown SGLT2 inhibitors provide organ protection in patients with type 2 diabetes, heart failure, and chronic kidney disease.1

Dapagliflozin is indicated to reduce the risk of sustained glomerular filtration rate (eGFR) decline, end-stage kidney disease, cardiovascular (CV) death, and hospitalization for heart failure in adult patients with CKD at risk of progression, according to AstraZeneca. The drug is also indicated to reduce the risk of CV death and hospitalization for heart failure in adults with heart failure with reduced ejection fraction, and to reduce the risk of hospitalization in adults with type 2 diabetes and either established CV disease or multiple CV risk factors. Dapagliflozin is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes, and is not recommended for patients with type 1 diabetes.2

DARE-19 compared dapagliflozin to placebo in 1250 patients hospitalized for COVID-19 who also had a history of hypertension, atherosclerotic cardiovascular disease, heart failure with either preserved or reduced ejection fraction, type 2 diabetes, or stage 3 to 4 chronic kidney disease with estimated eGFR between 25 and 60. Patients were recruited across 95 centers in seven countries between April 2020 and January 2021. Approximately half of the patients had a history of type 2 diabetes. Patients received dapagliflozin or placebo for 30 days in addition to the standard of care for COVID-19 in the participating hospital.1

According to the investigators, future trials are needed to further evaluate the possible effects of dapagliflozin on the risk of organ failure or death in patients hospitalized with COVID-19. They also noted that DARE-19 has important implications for future research, as it raises a hypothesis that SGLT2 inhibitors may offer organ protection in other types of acute illness such as sepsis, which should be explored in future studies.1

REFERENCES

Read the original:

Dapaglifozin Found to be Well-Tolerated in Hospitalized Patients With COVID-19 - Pharmacy Times

Posted in Covid-19 | Comments Off on Dapaglifozin Found to be Well-Tolerated in Hospitalized Patients With COVID-19 – Pharmacy Times