Monthly Archives: June 2021

Company offers space flights on the "balloon": the spacecraft has WiFi and drink menu | Technology – The Press Stories

Posted: June 28, 2021 at 10:15 pm

Presented by a North American company Space travel On a ship like a hot air balloon.

About Space view, The company that will start carrying out its commercial flights 2024, 230 seats already allocated year. Those interested can plan their trip from 2025 onwards.

The ship, so called Spacecraft NeptuneIt has a compressed capsule that has eight reclining seats for passengers and another for the pilot.

It will have 360-degree panoramic windows, a drinks bar, a place to store belongings, a WiFi connection with communication devices to allow live broadcasts, and sensors that indicate altitude, air and temperature throughout the aircraft.

For his part, The world of space It grows to the size of a football field and allows the capsule to fly upwards evenly.

The journey lasts six hours and must meet the minimum requirements required when boarding a passenger plane. The missions will begin at the Kennedy Space Center NASA.

The Spacecraft It will take two hours to climb until it reaches an altitude of 30 km. At that point, it would float in the atmosphere for two hours. Finally, they will return Land Two hours later land at sea, where a ship will retrieve the capsule, space balloon and explorers.

Technically it does not reach space Karman line, The boundary between the Earths atmosphere and space is 100 km. Despite this, it would be enough to see the curve of the earth.

Of course, traveling into space will not be cheap, as you can imagine. There is value in tickets 5,000 125,000I.e. 91 million 600 thousand Chilean pesos.

Those interested can choose between a single seat or a capsule for eight people, with a refundable $ 1,000 (733 thousand pesos).

Space view It recently called its first test balloon Neptune One, which did not carry any crew. The mission was successful, so they hope to continue conducting test flights in the coming months.

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Company offers space flights on the "balloon": the spacecraft has WiFi and drink menu | Technology - The Press Stories

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Digital Transformation Expert Prasamit Kalita joins Zinnov in the firm’s Digital Practice – PRNewswire

Posted: at 10:09 pm

NEW YORK, June 28, 2021 /PRNewswire/ -- Zinnov, a global management and strategy consulting firm, announced that Prasamit Kalita, an expert in Digital Transformation, with more than 15 years of experience in the Banking & Financial Services and Insurance sector, has joined the firm's Digital Practice as an Emerging Tech leader. Prasamit is based out of New York and will be advising clients on their modern tech strategy, with a special focus on BFSI companies.

Adoption of emerging technologies such as Cloud, Quantum Computing, 5G, Cybersecurity, NLP, Blockchain, Big Data, etc., across nearly every vertical has increased in recent years as companies begin to understand the strategic business value of this emerging technology stack. To unsheathe true value, enterprises are channelizing investments to fully leverage Cloud, investing in 5G, as well as modern technologies such as Quantum Computing and Qubits. The decision on how much to invest, how to prioritize investments, leveraging technology and building relevant capabilities to create a defensible moat, are still aspects that enterprises are grappling with.

"As enterprises strengthen their positioning and ride the wave of disruptions, they are increasingly leveraging modern technologies such as Cloud, AI, IoT, Big Data, Security, etc., to truly become autonomous. This has further been catalyzed by COVID shining a spotlight on the criticality of future-proofing businesses to withstand external shocks to become truly antifragile. Prasamit's experience in the emerging tech space will be a critical asset as we empower our enterprise customers in their own technology evolution. We're thrilled to have him on the team." Praveen Bhadada, Managing Partner, Zinnov

"We are excited to have Prasamit join our expanding Digital Practice in the US. His exemplary track record in orchestrating Digital Transformation initiatives across Operations, Business Effectiveness, Intelligence, Corporate Risk Management, Legal, Compliance, and Governance disciplines, coupled with his expertise in partnering with business leaders, defining corporate strategy, building intelligence networks, and standardizing risk appetite strategy, will be key assets in helping our enterprise customers achieve their long-term scaling goals." Sean Bouani, Partner, Zinnov

Prasamit's expansive experience spans across verticals at global financial giant, Deutsche Bank; financial technology and media conglomerate, Thomson Reuters; global consulting firm, EY; and his latest stint as a sociopreneur at TPI. He has worked with CXOs and digital transformation leaders to implement various applications in his stint at Deutsche Bank and Thomson Reuters. Prasamit has collaborated and led both technical and business teams to design end-to-end digital solutions, delivering high value ROI to all stakeholders involved.

"I'm delighted to be joining Zinnov, given their rich insights, knowledge, and experience in the Emerging Tech space. Zinnov's remarkable reputation for being a customer-centric consulting firm that prides itself on delivering deep insights focused on business and technology ROI for its clients, was one of the biggest draws for me to join the company. I hope to continue that tradition as I work closely with Fortune 500 and enterprise customers to accelerate and optimize their portfolios in the emerging tech space to deliver long-term value in the United States." Prasamit Kalita, Principal, Zinnov

For an interview with Prasamit Kalita, please drop a note to [emailprotected].

About Zinnov

Founded in 2002, Zinnov is a global management consulting firm, with a presence across 4 continents. Zinnov has successfully delivered high value business transformation to 250+ Fortune 500 enterprises enabling them to accelerate their Digital Transformation outcomes by leveraging technologies such as Hyper Intelligent Automation (HIA), AI/ML, Cloud, IoT, etc.

Media ContactNitika GoelChief Marketing Officer Zinnov[emailprotected]

SOURCE Zinnov

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Digital Transformation Expert Prasamit Kalita joins Zinnov in the firm's Digital Practice - PRNewswire

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Protection from hackers: How Tor is tightening security – DW (English)

Posted: at 10:08 pm

People who value a high level of privacy protectionor who depend on this protection for political reasonscan access websites using Tor without leaving any traces on the net. With a Tor browser, users'internet traffic is automatically routed through several Tor servers, which ensure anonymity through encryption. Only then does it go to the actual destination:the web server users intendto visit.

This process is called routing. Tor actually stands for "The Onion Routing"because the Tor servers layer their encryption on top of the encryption of other servers reminiscent of onionlayers.

Tor is secure by design. For this reason, there have hardly been any major security incidents to the detriment of users. Its browser, which is based on the Firefox browser, is continuously developed and secured by the free, open source Tor project.

Content providers who want to offer their content directly in the Tor network operate an "onion service." This is a web server that is directly connected to the Tor network. These websites can be recognized by the extension .onionand can only be accessed via the Tor browser.

Deutsche Welle has also been operating its own onion service for some time, making it easier for users all over the world to access free media anonymously especially people who fear repression for using such free media. Tor can also be a useful tool for journalists, for example when they cannot conduct regular research because they are being persecuted by state actors and intelligence agencies. This is crucial because fear of surveillance alone canquickly lead to self-censorship.

Tor not only protects users' anonymity, but also offers them paths to free information in censored markets.

For example, authoritarian states often block content from international information providers such as DW, the BBC and The New York Times. With Tor, this state censorship can be circumvented. The previous web address of Deutsche Welle was:https://dwnewsvdyyiamwnp.onion.

But this is now changing.

As you can probably already tell from the long and difficult-to-readonion service addresses, cryptography is involved here. Tor does not have a central domain systemwhich forwardsreadable web addresses like dw.com to the IP addresses of computers.

Address allocation is decentralized and consists of a cryptographic key. This makes it particularly secure. Part of this key is the onion service address.

Attackers can get hold of such a key by brute force. So far, they have mostly used these attacks to hack passwords.

The longer the key or password, the more computing power is required and the more difficult such an attack becomes.

It is precisely this massive computing power that is now available to some authoritarian regimes in the form of Bitcoin mining farms. In recent months, computing capacity has grown very quickly in countries such as China and Iran.

As a result, the Tor project has decided to only support addresses with a length of 56 characters and has adopted the "Onion v3 standard" for this purpose. Addresses in the new standard are considered secure for the next few years, not only because of their greater length, but also because of other modern cryptographic functions.

DW's new onion service address as of now is:

https://dwnewsgngmhlplxy6o2twtfgjnrnjxbegbwqx6wnotdhkzt562tszfid.onion

Because these v3 addresses are very difficult to read and remember, it is also sufficient to enter the publicly known addresses in the Tor browser for exampl:e dw.com. The browser then offers to use the complicated Tor address once and automatically on future page requests.

But be careful: This procedure means that you briefly leavethe secure Tor network, so users who need the highest level of anonymity should only use the long cryptographic v3 Tor address.

Shortly after winning a major prize at the Cannes Film Festival with "A Man of Integrity," the Hamburg-based director returned to Iran in September 2017. Iranian authorities then confiscated Rasoulof's passport and banned him from directing new films. In July 2019, he was sentenced to a year in prison. He nevertheless managed to shoot "There Is No Evil" (photo), which won the Golden Bear in 2020.

Abdolreza Kahani migrated to France in 2015 after three of his films were banned in the Islamic Republic and he was prevented from submitting them to international festivals. "We are born into censorship. Censorship affects not just literature, music and film. Censorship begins inside the home," he told the Center for Human Rights in Iran (CHRI) in a recent interview.

Getting a screening permit for films that premiered at world festivals can take years: Kianoush Ayari's "The Paternal House," from 2012, was only released in Iran last year after the director agreed to make some edits. But a week later, in November 2019, the film was banned, prompting 200 film personalities to sign an open letter condemning state censorship and calling for freedom of expression.

He is one of the few directors to have won the Oscar for best foreign film twice: "A Separation" (2012) and in 2016, "The Salesman" (photo). Farhadi boycotted the second ceremony, which took place shortly after Trump's "Muslim travel ban." Even though Iranian officials were behind Farhadi's Oscar entries, the filmmaker was among the signatories of the 2019 open call condemning state censorship.

Iranian-Kurdish filmmaker Bahman Ghobadi directed the world's first Kurdish-language feature film, the 2000 "A Time for Drunken Horses" (photo). Following his semi-documentary about the underground indie music scene in Tehran, "No One Knows About Persian Cats" (2009), Ghobadi fled Iran, as intelligence agents repeatedly threatened him and urged him to leave. Those two films won awards at Cannes.

Having permanently left Iran as a young adult, Marjane Satrapi didn't have to deal with Iranian authorities as an author and filmmaker. Her best-known comic book, "Persepolis" (photo) adapted into a film that won the Cannes Jury Prize in 2007, offers a personal depiction of how a teenager can get into trouble with the police by disregarding modesty codes and buying music banned by the regime.

Released shortly before the 9/11 attacks, Mohsen Makhmalbaf's 2001 film, "Kandahar," became a must-see work about the fate of Afghan women. Many of the award-winning director's films are banned in Iran, and he left the country to live in France after Mahmoud Ahmadinejad's election. His most recent feature film, "The President" (photo) opened the Venice Film Festival in 2014.

The daughter of Mohsen Makhmalbaf is one of the most influential directors of the Iranian New Wave. Her first feature film, "The Apple," which she directed at the age of 17, premiered at the Cannes Film Festival in 1998. Two years later, she won the Cannes Jury Prize with "Blackboards. (photo). She then became the youngest person to sit on the jury of festivals such as Cannes, Venice and Berlin.

Winning a Cannes award with his 1995 feature debut, "The White Balloon," Panahi kept receiving international acclaim despite increasing restrictions in Iran. Since 2010, he has been banned from making films and leaving the country, but still managed to secretly direct more works, including the Golden Bear-winning "Taxi" (2015) and "3 Faces" (photo), which won Cannes' best screenplay prize in 2018.

A decade after winning the International Award at the Venice Biennale, the visual artist's feature debut, "Women Without Men" (photo) was also honored at the Venice film festival in 2009. A critic of political injustice, Neshat lives in self-imposed exile in New York. "While I am critical of the West, women artists in Iran still face censorship, torture and, at times, execution," she said.

Author: Elizabeth Grenier

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Protection from hackers: How Tor is tightening security - DW (English)

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Patch Tor Browser Bug to Prevent Tracking of Your Online Activities – The Hacker News

Posted: at 10:08 pm

Open-source Tor browser has been updated to version 10.0.18 with fixes for multiple issues, including a privacy-defeating bug that could be used to uniquely fingerprint users across different browsers based on the apps installed on a computer.

In addition to updating Tor to 0.4.5.9, the browser's Android version has been upgraded to Firefox to version 89.1.1, alongside incorporating patches rolled out by Mozilla for several security vulnerabilities addressed in Firefox 89.

Chief among the rectified issues is a new fingerprinting attack that came to light last month. Dubbed scheme flooding, the vulnerability enables a malicious website to leverage information about installed apps on the system to assign users a permanent unique identifier even when they switch browsers, use incognito mode, or a VPN.

Put differently, the weakness takes advantage of custom URL schemes in apps as an attack vector, allowing a bad actor to track a device's user between different browsers, including Chrome, Firefox, Microsoft Edge, Safari, and even Tor, effectively circumventing cross-browser anonymity protections on Windows, Linux, and macOS.

"A website exploiting the scheme flooding vulnerability could create a stable and unique identifier that can link those browsing identities together," FingerprintJS researcher Konstantin Darutkin said.

Currently, the attack checks a list of 24 installed applications that consists of Adobe, Battle.net, Discord, Epic Games, ExpressVPN, Facebook Messenger, Figma, Hotspot Shield, iTunes, Microsoft Word, NordVPN, Notion, Postman, Sketch, Skype, Slack, Spotify, Steam, TeamViewer, Telegram, Visual Studio Code, WhatsApp, Xcode, and Zoom.

The issue has serious implications for privacy as it could be exploited by adversaries to unmask Tor users by correlating their browsing activities as they switch to a non-anonymizing browser, such as Google Chrome. To counter the attack, Tor now sets "network.protocol-handler.external" to false so as to block the browser from probing installed apps.

Of the other three browsers, while Google Chrome features built-in safeguards against scheme flooding it prevents launching any application unless it's triggered by a user gesture, like a mouse click the browser's PDF Viewer was found to bypass this mitigation.

"Until this vulnerability is fixed, the only way to have private browsing sessions not associated with your primary device is to use another device altogether," Darutkin said. Tor browser users are recommended to move quickly to apply the update to ensure they are protected.

The development arrives little over a week after encrypted messaging service Wire addressed two critical vulnerabilities in its iOS and web app that could lead to a denial-of-service (CVE-2021-32666) and permit an attacker to take control of a user account (CVE-2021-32683).

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This Week In Security: Schemeflood, Modern Wardialing, And More! – Hackaday

Posted: at 10:08 pm

Theres been yet another technique discovered to fingerprint users, and this one can even work in the Tor browser. Scheme flooding works by making calls to application URLs, something like steam://browsemedia. If your machine supports the requested custom URL, a pop-up is displayed, asking permission to launch the external application. That pop-up can be detected by JavaScript in the browser. Detect enough apps, and you can build a reasonable fingerprint of the system the test is run on. Unlike some previous fingerprinting techniques, this one isnt browser dependent it will theoretically give the same results for any browser. This means even the Tor browser, or any browser being used over the Tor network, can give your potentially unique set of installed programs away.

Now for the good news. The Chrome devs are already working on this issue, and in fact, Chrome on my Linux desktop didnt respond to the probes in a useful way. Feel free to check out the demo, and see if the results are accurate. And as for Tor, you really should be running that on a dedicated system or in a VM if you really need to stay anonymous. And disable JavaScript if you dont want the Internet to run code on your computer.

Windows system security and Linux system security are quite different. OK, thats probably both something of an understatement, and pretty obvious. In a project like Samba, which re-implements the Server Message Block protocol, those differences are a constant challenge. Sometimes, like in the case of CVE-2021-20254, the results are unusual.

This story really begins at Linkping University, where [Peter Eriksson] discovered that someone was able to delete a file on a Samba share, when that should not have been possible. He apparently tracked down the problem, which is in the Samba code that maps Windows SIDs to Unix Group IDs. Samba caches these lookups, and a possible cached result is that a match cannot be found. The bug is triggered when that cached response is fetched again, reading past the end of the buffer. There isnt a known technique for triggering this bug intentionally, but thats likely a failure of imagination, so make sure you get this one patched.

There are odd machines still connected to the Plain Old Telephone System (POTS). This thought was apparently keeping [Valtteri Lehtinen] up at night, because he built a system to call 56,874 different phone numbers, and then documented what he found. His testing rig is a bit odd, using WarVOX as the dialer. That program only supports IAX2, a VoIP protocol introduced by the Asterisk project that has been mostly forgotten in favor of SIP. His interface to the outside world was a SIP-to-GSM gateway and a cheap prepaid SIM card. To make WarVOX talk to the SIP gateway, he stood up an Asterisk instance to do the translation. His target was the freephone numbers, similar to a 1-800 number in the States mostly businesses rather than individuals.

He spent 60 seconds per call, and recorded the results, running the experiment for 40 days. His results? About 2% of the numbers were interesting. He categorized those, and came up with 74 unique systems he had reached. For an example of what that means, seven of his calls reached dedicated fax lines. These were indistinguishable from each other, so only accounts for a single unique system. Eleven calls just played music, but several of those seemed to be playing the exact same music, making for seven unique systems.

There are a few really oddball recordings that [Valtteri] found. Two numbers contain a prompt about the zombie apocalypse, asking the caller if he wants to be rescued. These remind me very much of the various joke phone numbers, like the rejection hotline. He also found a couple numbers that sound very much like old mechanical phone switching hardware. Wouldnt it be interesting to know exactly what hardware is on the other end of those calls? We cant recommend taking up wardialing as a hobby, but there are certainly still some interesting endpoints out there. Want to look into the recordings for yourself? Check out his blog post, where many of the recordings are available to listen to.

Theres a very odd problem with the iPhone thats attracted a lot of attention this week. Connecting to a WiFi network with a name like %p%s%s%s%s%n made the phones WiFi subsystem crash, and prevented connection to any other networks. That string looks interesting, doesnt it? Almost like a format string. For those not following, most programming languages have string formatting functions that take a series of inputs, combined with a format string like this one, and plug the inputs into the string. Cs printf() is one of the more familiar to many of us. The catch here is that when the inputs dont match what the string calls for, you enter the realm of undefined behavior, AKA crashes and vulnerabilities.

[CodeColorist] took a deeper look at the problem, and confirmed that it is indeed a format string issue. When the device attempts to connect to a new WiFi network, a message is written to the system log: Attempting Apple80211AssociateAsync to and then the network name, using a format string method. The process of writing the string to the log invokes another such method, but this time the SSID is now part of the format string. The inputs no longer match, leading to a crash of the WiFi process. While its certainly an annoying bug, it doesnt appear to be one that can lead to RCE.

Password reset systems have always been something of a weak point of security schemes. Of particular note are the schemes that use a four- or six-digit reset code to protect the account. Have you ever wondered what stops an attacker from triggering a reset, and then simply trying all one million possible codes, assuming a six-digit number? The usual answer is a combination of expiring codes and rate limiting on guesses. This story is about Apple accounts, but the background is that [Laxman Muthiyah] first found a way to exploit the password reset function of Instagram.

Heres the setup. When you start the password reset process on Instagram, a six-digit code is emailed to the email address on file. If you have access to that email, you type in the code within ten minutes, proving that youre the account owner. After ten minutes, the code expires. If youre an attacker, you can start the password reset process, and then guess that six-digit code again, one million possible values. Try to brute force the code, and about 200 attempts go through before the rate-limiting kicks in. That gives you a 1-in-5,000 chance in breaking into the account.

What if there was a way to get around the rate-limiting? Hint: There was. You see, trying to send more than 200 guesses from a single IP was easily detected and rate-limited. But what if you had two different IPs? Send 200 guesses from each, at the same time, and they all get processed with no rate limiting. So to take over an Instagram account, all it takes is 5,000 IPs that you can send traffic from for a few seconds. Now how would you get 5,000 IPs to use? Three options come to mind. The cloud, a botnet, or IPv6 addresses. He used a cloud to demonstrate the attack, covering 20% of the possible key space in a single go. He netted a cool $30,000 from turning in the findings to Facebook.

Would other providers have the same weakness? [Muthiyah] took a look at Apples account recovery process, and found a way to pull off the same attack, but with some major limitations. Rather than 200 guesses from each IP, he could send six. That isnt enough for a viable attack but the target URL endpoint exists on six different IPs. That gives an attacker 36 guesses from each IP he controls. Thats on the edge of being exploitable, with only 28,000 IPs needed. Thats a *small* botnet. Apple agreed, asking him to keep the attack under his hat until they could push out fixes.

The story gets weird from here. First, what should have been a relatively simple fix took about ten months to roll out. [Laxman] asked for an update, and was told that his attack only worked against accounts not tied to a hardware device. Accounts tied to a device use a bit different password reset method, where a hashing function is used to prove that the user knows the reset code. That URL endpoint is now very well protected against his parallel brute-force attack, but he was only able to test it after the flaw was fixed.

For his trouble, Apple offered him $18,000. Sounds great, right? Hold up. A vulnerability that leads to an Apple account takeover should be worth $100,000; and if that leads to data extraction from a device, it goes up to $250,000. [Laxman] openly speculates that his attack probably worked on all accounts before it was patched, and suspects Apple of pulling a fast one. He walked away from the offered bounty, and posted the entire story for everyone to see. This isnt the first time weve covered disputes over bug bounties, and Im sure it wont be the last.

Eclypsium found a handful of problems with Dells firmware update process. BIOSConnect is a firmware update process that runs entirely from the system BIOS. From what I can tell, this means that a Dell machine could be vulnerable even if it isnt running Dells SupportAssist, or even Windows at all. The BIOS makes an HTTPS request to downloads.dell.com, but fails to properly validate the TLS certificate. It seems that any wildcard certificate for any domain will be accepted. You could fool it as easily as using a Lets Encrypt certificate for *.myuniquedomain.com, and telling an HTTPS server to use that cert for dell.com.

The saving grace here is that an attacker needs to be on the same network as the victim machine, in order to MItM the connection to the update server. Either way, if you have Dell hardware, go check for this issue and update if its there, or at least turn off BIOSConnect.

Theres been a rash of ransomware attacks against consumer NAS devices, and it looks like Western Digitals My Book Live might be the next device to be hit. Multiple users discovered their drives wiped on the 23rd, and a log note that a factory restore had been triggered. WD has released a statement, acknowledging the issue, and recommending that anyone with a My Book Live unplug it from the network right away, and leave it offline until they can get to the bottom of the issue. The latest official news is a reference to a 2018 CVE, a pre-auth network RCE. What immediately comes to mind is that a particularly obnoxious ransomware program could include this attack as part of an effort to destroy backups. The odd part is that none of the affected users have reported a ransomware note.

Microsoft announced Windows 11, and while there was the normal marketing hype and keynotes, there were a couple interesting security-related tidbits, mostly in the updated system requirements. First up is the Trusted Platform Module 2.0 requirement. Most modern motherboards ship with a firmware TPM, but often disabled by default. If you try running the upgrade check, and were told that your nearly-new system cant run Windows 11, thats probably why. But why would Microsoft require a TPM for everyone? Credit to Robert Graham for this one: TPM is a requirement for BitLocker, the high quality whole disk encryption software built into Windows. This would indicate that BitLocker is going to be on for everyone, rather than a feature you have to manually enable.

The other somewhat surprising change is that Microsoft is doing away with support for 32-bit processors, and going to 64-bit Windows only. There are sure to be some issues for people still running 16-bit code, which wont execute at all under 64-bit Windows. There are, however, quite a few security features that only run on 64-bit windows, like ASLR, signed drivers, the NX bit for Data Execution Protection, and PatchGuard. While the reduced engineering burden of dropping 32-bit Windows was likely the major driver in this decision, the Windows platform will be significantly more secure as a result.

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This Week In Security: Schemeflood, Modern Wardialing, And More! - Hackaday

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Study suggests scientists may need to rethink which genes control aging – National Institutes of Health

Posted: at 10:07 pm

News Release

Thursday, June 24, 2021

NIH scientists discover that bacteria may drive activity of many hallmark aging genes in flies.

To better understand the role of bacteria in health and disease, National Institutes of Health researchers fed fruit flies antibiotics and monitored the lifetime activity of hundreds of genes that scientists have traditionally thought control aging. To their surprise, the antibiotics not only extended the lives of the flies but also dramatically changed the activity of many of these genes. Their results suggested that only about 30% of the genes traditionally associated with aging set an animals internal clock while the rest reflect the bodys response to bacteria.

For decades scientists have been developing a hit list of common aging genes. These genes are thought to control the aging process throughout the animal kingdom, from worms to mice to humans, said Edward Giniger, Ph.D., senior investigator, at the NIHs National Institute of Neurological Disorders and Stroke (NINDS) and the senior author of the study published in iScience. We were shocked to find that only about 30% of these genes may be directly involved in the aging process. We hope that these results will help medical researchers better understand the forces that underlie several age-related disorders.

The results happened by accident. Dr. Ginigers team studies the genetics of aging in a type of fruit fly called Drosophila. Previously, the team showed how a hyperactive immune system may play a critical role in the neural damage that underlies several aging brain disorders. However, that study did not examine the role that bacteria may have in this process.

To test this idea, they raised newborn male flies on antibiotics to prevent bacteria growth. At first, they thought that the antibiotics would have little or no effect. But, when they looked at the results, they saw something interesting. The antibiotics lengthened the flys lives by about six days, from 57 days for control flies to 63 for the treated ones.

This is a big jump in age for flies. In humans, it would be the equivalent of gaining about 20 years of life, said Arvind Kumar Shukla, Ph.D., a post-doctoral fellow on Dr. Ginigers team and the lead author of the study. We were totally caught off guard and it made us wonder why these flies took so long to die.

Dr. Shukla and his colleagues looked for clues in the genes of the flies. Specially, they used advanced genetic techniques to monitor gene activity in the heads of 10, 30, and 45-day old flies. In a previous study, the team discovered links between the age of a fly and the activity of several genes. In this study, they found that raising the flies on antibiotics broke many of these links.

Overall, the gene activity of the flies fed antibiotics changed very little with age. Regardless of their actual age, the treated flies genetically looked like 30-day old control flies. This appeared to be due to a flat line in the activity of about 70% of the genes the researchers surveyed, many of which are thought to control aging.

At first, we had a hard time believing the results. Many of these genes are classical hallmarks of aging and yet our results suggested that their activity is more a function of the presence of bacteria rather than the aging process, said Dr. Shukla.

Notably, this included genes that control stress and immunity. The researchers tested the impact that the antibiotics had on these genes by starving some flies or infecting others with harmful bacteria and found no clear trend. At some ages, the antibiotics helped flies survive starvation or infection longer than normal whereas at other ages the drugs either had no effect or reduced the chances of survival.

Further experiments supported the results. For instance, the researchers saw similar results on gene activity when they prevented the growth of bacteria by raising the flies in a completely sterile environment without the antibiotics. They also saw a similar trend when they reanalyzed the data from another study that had raised flies on antibiotics. Again, the antibiotics severed many of the links between aging and hallmark gene activity.

Finally, the team found an explanation for why antibiotics extended the lives of flies in the remaining 30% of the genes they analyzed. In short, the rate at which the activity of these genes changed with age was slower than normal in flies that were fed antibiotics.

Interestingly, many of these genes are known to control sleep-wake cycles, the detection of odorants, and the maintenance of exoskeletons, or the crunchy shells that encase flies. Experiments on sleep-wake cycles supported the link between these genes and aging. The activity of awake flies decreased with age and this trend was enhanced by treating the flies with antibiotics.

We found that there are some genes that are in fact setting the bodys internal clock, said Dr. Giniger. In the future, we plan to locate which genes are truly linked to the aging process. If we want to combat aging, then we need to know precisely which genes are setting the clock.

This study was supported by the NIH Intramural Research Program at the NINDS.

This press release describes a basic research finding. Basic research increases our understanding of human behavior and biology, which is foundational to advancing new and better ways to prevent, diagnose, and treat disease. Science is an unpredictable and incremental process each research advance builds on past discoveries, often in unexpected ways. Most clinical advances would not be possible without the knowledge of fundamental basic research. To learn more about basic research, visit https://www.nih.gov/news-events/basic-research-digital-media-kit.

NINDSis the nations leading funder of research on the brain and nervous system.The mission of NINDS is to seek fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease.

About the National Institutes of Health (NIH):NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

NIHTurning Discovery Into Health

Shukla, A.K. et al., Common features of aging fail to occur in Drosophila raised without a bacterial microbiome, iScience, June 24, 2021, DOI: 10.1016/j.isci.2021.102703

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Study suggests scientists may need to rethink which genes control aging - National Institutes of Health

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Longevity and Anti-Senescence Therapy Market 2021 Size, Status and Global Outlook Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc.,…

Posted: at 10:06 pm

Longevity and Anti-Senescence Therapy Market Growth 20202027 is the latest updated report announced by Oneup Business Insights which is a complete research study on the market, which attempts to provide a clear picture of the key factors that shape this market.

This marketplace additionally analyzes the marketplace status, share, demand, boom rate, destiny trends, marketplace drivers, opportunities, and challenges, dangers and access barriers, income channels, and vendors with the assistance of SWOT evaluation and Porters Five Forces Analysis. In this bit of the research the organizations chief outlines, monetary outlines, and field-tested strategies are introduced.

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Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc., Insilico Medicine, Oisin Biotechnology, Proteostasis Therapeutics Inc., Recursion Pharmaceuticals, Restorbio, Senex Biotechnology, Senolytic Therapeutics, and Sierra Sciences LLC

Segmentation of Longevity and Anti-Senescence Therapy Market:

Product Type Coverage

Hemolytic Drug Therapy

Gene Therapy

Immunotherapy

Other Stem Cell Therapies

Application Coverage

Hospital

Medical Service Institution

Drug and Device Sales

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North America

Europe

Asia Pacific

Latin America

The Middle East and Africa

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Table of Contents: Longevity and Anti-Senescence Therapy Market:

Chapter 1: Overview of Longevity and Anti-Senescence Therapy Market

Chapter 2: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Regions

Chapter 3: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Types

Chapter 4: Global Longevity and Anti-Senescence Therapy Market Status and Forecast by Downstream Industry

Chapter 5: Longevity and Anti-Senescence Therapy Market Driving Factor Analysis

Chapter 6: Longevity and Anti-Senescence Therapy Market Competition Status by Major Manufacturers

Chapter 7: Major Manufacturers Introduction and Longevity and Anti-Senescence Therapy Market Data

Chapter 8: Upstream and Downstream Longevity and Anti-Senescence Therapy Market Analysis

Chapter 9: Cost and Gross Margin Analysis of Longevity and Anti-Senescence Therapy market

Chapter 10: Marketing Status Analysis of Longevity and Anti-Senescence Therapy market

Chapter 11: Longevity and Anti-Senescence Therapy Market Report Conclusion

Chapter 12: Longevity and Anti-Senescence Therapy Market Research Methodology and Reference

Research Objectives of this report:

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Longevity and Anti-Senescence Therapy Market 2021 Size, Status and Global Outlook Acorda Therapeutics, Calico Life Sciences, Human Longevity Inc.,...

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How to live longer: Two surprising foods that help fight decline in later life – Daily Express

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"I was pleasantly surprised that our results suggest that responsibly eating cheese and drinking red wine daily are not just good for helping us cope with our current COVID-19 pandemic, but perhaps also dealing with an increasingly complex world that never seems to slow down," Willette said.

"While we took into account whether this was just due to what well-off people eat and drink, randomised clinical trials are needed to determine if making easy changes in our diet could help our brains in significant ways."

Weekly consumption of lamb, but not other red meats, was shown to improve long-term cognitive function.

Excessive consumption of salt is invariably bad, but only individuals already at risk for Alzheimer's Disease may need to watch their intake to avoid cognitive problems over time, the study suggested.

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How to live longer: Two surprising foods that help fight decline in later life - Daily Express

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What if marmosets lived on the Moon? – The Economist

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Jul 3rd 2021

CAIRD COLLECTIVE, LUNA

Editors note: This year What If?, our annual collection of scenarios, considers the future of health. Each of these stories is ction, but grounded in historical fact, current speculation and real science. They do not present a unied narrative but are set in dierent possible futures

THEY CAN, at times, look somewhat sinister, their faces oddly small for their heads, their white ear tufts jutting out almost aggressively. Their ability to throw themselves at people across seemingly unfeasible distances can be unsettling, and their buzzing and shrieking takes a lot of getting used to, as does their smell. But the members of the Caird collective will not hear a word spoken against the marmosets with whom they share their spaces at the Moons South Pole. As they sit in their insulated caves hoovering moondust out of the animals tails, few of the Cairders can imagine their life on the rim of Shackleton crater without themand none wants to. The marmosets of the Moon are the first and best example of what has turned out to be a fundamental fact of space flight: that the further humans get from Earth, the more they benefit from the companionship of other Earthly animals.

The marmosets were originally brought to the Moon as unwilling participants in a vital research project. Marmosets are lighteven under Earth gravityand reasonably easy to care for, but they have placentas much more like those of humans than any other animal their size, and reasonably short gestation periods. That made them ideal for looking at a fundamental question: can humans have healthy pregnancies in the low gravity of the Moon, where things weigh only one-sixth what they do on Earth?

In the 2020s and 2030s, the years of what the novelist Wil McCarthy called the Rich Mans Sky, questions of obstetrics and gynaecology received remarkably little attention. For many, the idea of staying in space long enough for such things to matter made little sensespace stations in Earth orbit and bases on the Moon were places for fixed-length work contracts and research sojourns, or for tourism. Babies were no more of an issue than they were in isolated 20th-century Antarctic research outposts.

There were, as it happens, a few babies born in Antarctica even back then, when its ice cover was all but intact. The Argentine and Chilean governments both saw the creation of natives on the continent as a way to establish sovereignty and arranged births to that end. But there was no reason to think that Antarctica was inimical to pregnancy and infancy. The long-term health effects of low gravity and microgravitywhich for those in orbit include brittle bones, muscle wasting and eye diseasewere something else. Adults could counter some of these effects with treadmills and tension cords. But as the title of an early paper on the subject succinctly put it, The fetus cannot exercise like an astronaut.

Even those, like Elon Musk, who talked of permanent settlements on Mars spent little time working on the question. It was left to a small team of scientists in the Japanese modules of the Artemis base founded in 2029 by America and its allies to explore the question experimentally with the help of marmosets, gene-splicing technology, intra-uterine monitoring devices and a giant centrifuge.

They had some success. Like human fetuses, marmoset fetuses spend most of their gestation with a density equal to that of the amniotic fluid around them, a neutral buoyancy that leaves them indifferent to local gravity; only relatively late on do differences due to gravity start to crop up. After a few years of trial and error, and some dainty gene-editing to rebalance the rate at which bones grow when not stressed through use, the researchers developed a regime involving hormone treatments for the mothers and regular late-pregnancy sessions in their custom-made room-sized centrifuge, known as the marmo-go-round. This reliably produced pups with strong-enough bones and muscles and little by way of deformity, though their tails were impressively long even by marmoset standards.

Unfortunately, in 2038 that research was interrupted by the geopolitical meltdown of the wolf-and-wimp war and then by the 26 months of the Great Grounding. With all powered flight within or through the Earths atmosphere prohibited, the various Moon bases seemed doomed even after they agreed to pool their resources to create what became known as the Polynational James Caird Collective. With all the groups biotech know-how turned to increasing food production and nutrient recycling, the marmosets were at first ignored and then freed to roam within the bases. Their effect on morale was instantaneous and profound.

The importance of companion animals to the mental health of people engaged in a homeless lifestyle was well documented in pre-war societies. It has been suggested that the effect of the marmosets on the Caird collective was similar; cut off from Earth, the humans were more homeless than any group of people had ever been before. Caring for, playing with and grooming marmosets also became a basis for bonding between humans, many of whom had not known each other before the Grounding, and some of whose countries had been adversaries in the war. By the time the mysterious entity responsible for the Great Grounding finally abandoned its control of the Earths air-traffic-control and missile-defence systems, allowing traffic with the Moon to resume, the marmosets had become an indispensable part of the settlers new identity and society. Few believe that a lack of companion animals was, in itself, the reason that the Mars base failed during the Grounding. But it surely did not help.

The bond between the Moons larger and smaller primates persisted even as the rigours of separation came to an end. Almost all Cairders still dislike spending any significant time deprived of marmoset company. They cuddle them and relish their low-gravity acrobatics. In a joking way that seems, at some level, not to be a joke, they treat the abnormally long tails of the Moon-born marmosets as a sign of providence, holding the tail-fur to be particularly good at picking up moondust. The dust, which can cause lung disease, infiltrates their habitats despite all the airlock precautions; its suppression is a constant battle. Whether hoovering it out of tails which accumulate it in the manner of a feather duster is in fact more effective than the settlements electrostatic air-filtration systems is open to question. But it is clearly more therapeutic. And the marmosets enjoy the attention.

The oldest Earth-born marmoset, New Mrs Chippy (who is, despite his name, male) enjoys an honorary seat on the collectives council. He has now reached the age of 31 with no obvious signs of ageing other than a pelt almost as white as his ear tufts. This is seen as a good omen for human longevity among those Cairders who refuse to countenance a return to Earth. In Japan, by contrast, laboratory marmosets rarely make it past their 21st birthday.

The most salient biological, as opposed to sociological, novelty among Moon-born marmosets is a very high prevalence of adolescent-onset blindness. The constellation of eyesight problems known as Spaceflight Associated Neuro-ocular Syndrome (SANS) has been studied since early this century. In adult humans SANS normally develops only during long stays in the microgravity conditions of space stations; it is rare and mild among humans on the Moon. But in marmosets born in low gravity it develops swiftly and severely at the onset of puberty and leads to almost complete loss of vision.

There is as yet no agreed explanation for this pathology. Some researchers believe it is not in fact gravity-related but the result of an off-target effect of the gene editing which realigned the calcium pathways used in bone growth, but it is hard to square this with the similarity to SANS as experienced by genotypical adult humans. Others think its onset could be avoided if newborn pups were required to spend more, or all, of their time in the simulated Earth-normal gravity of the centrifuge. But it has proved hard to test this hypothesis. Infants that have spent any time at all in lunar gravity are greatly distressed by the rigours of the centrifuge and will not suckle when put into it. And Cairders are unanimous in their opposition to anything that causes marmosets distress.

The blind marmosets are not badly off. Their sibling groups and human companions provide what little practical support they need. And they are happier than sighted marmosets to travel in the pouches which many Cairders have incorporated into the suits they use for working on the lunar surface. Sighted marmosets are clearly disturbed by the harsh monochrome landscape, even when emotionally supported with the amplified sound of their companions heartbeat.

Sudden-onset SANS leaves the question of whether human children can be born and raised on the Moon unanswered. It is sometimes suggested that a blind woman happy with the idea of a child who might also be blind could choose to join the collective and explore the issue. But bringing a child to term would require a centrifuge capable of holding a grown human, rather than a 250-gram marmoset. There is no appetite among Cairders for devoting resources to such a project, and their juche ethic of self-sufficiency will not let them accept funding for such experiments from Earth. Thus how well humans may eventually be able to breed on alien worlds remains unknown, even today.

That they will take animal companions with them, though, now seems certain. And some of those companions will surely have shocking-white ear tufts, odd little faces and very long tails.

Full contents of this What If?Freedom to tinker, October 2029: What if biohackers injected themselves with mRNA?The other epidemic, June 2025: What if America tackled its opioid crisis?A tale of two cities, June 2041: What if a deadly heatwave hit India?You are what you eat, January 2035: What if everyones nutrition was personalised?iHealthy, September 2028: What if smartphones become personal health assistants?Mrs Chippys benediction, February 2055: What if marmosets lived on the Moon?*Novel treatments, August 2050: What if dementia was preventable and treatable?Rage against the machine, December 2036: What if an AI wins the Nobel prize for medicine?Germ of an idea: What if germ theory had caught on sooner?

This article appeared in the What If? section of the print edition under the headline "Mrs Chippys benediction"

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HHS report says nursing home deaths rose by 32 percent due to COVID-19 | TheHill – The Hill

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A new report underscores the devastating toll COVID-19 took on nursing home residents, outlining an overall increase in the mortality rate of nursing home residents by 32 percent in 2020 compared to year-over-year data.

Released by the U.S. Department of Health and Human Services (HHS), the report looks at 2020 data on the number of nursing home residents and Medicare beneficiaries who were either diagnosed with or likely had COVID-19, as well as those who died from causes related to the virus.

The results indicate that the overall mortality rate rose by 32 percent, and numerical death statistics showed that in April 2020 alone, as the pandemic peaked in the U.S., 81,484 Medicare beneficiaries in nursing homes died.

This amounts to a 1,000-person increase in fatalities per day compared with April 2019 rates.

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Among those in nursing homes and on Medicare who were diagnosed with COVID-19 in 2020, 51 percent were Black, compared to 41 percent who were white.

Hispanic and Asian residents also experienced a higher chance of testing positive for the virus than their white counterparts. This coincides with national data noting Black, Hispanic and Native Americans are more likely to suffer severe illnesses related to COVID-19, part of longstanding racist disparities in access to health care.

The authors noted that this data can help illustrate how to handle future outbreaks among nursing home residents and staff to better prevent high mortality rates.

We knew this was going to be bad, but I dont think even those of us who work in this area thought it was going to be this bad, David Grabowski, a Harvard health policy professor, told The Associated Press.

One of the first COVID-19 outbreaks to occur on U.S. soil was at the Kirkland Nursing Home outside of Seattle, Washington. There 35 people, workers and residents, died from COVID-19, and roughly 66 percent tested positive for the virus.

Inspector General Nancy Harrison, who helped author the report, said that the country needs to learn from the disproportionate impact COVID-19 had on nursing homes.

Hopefully, COVID will go away, she said to AP reporters. But once that happens, there will always be infectious diseases, and we all need to ask ourselves what we can do to protect vulnerable nursing home residents going forward.

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WHO ADVISER ACCUSES CHINA OF MASSIVE AND STILL-ACTIVE COVID-19 COVER-UP

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