Daily Archives: June 2, 2021

SkinBioTherapeutics "delighted" with psoriasis study results, with 76% reporting less itchy skin – Proactive Investors UK

Posted: June 2, 2021 at 5:51 am

() Stuart Ashman joins Proactive London to discuss results from a study of people suffering from psoriasis that received its immune system-modulating food supplement delivering results that exceeded expectations.

In all 91 people with the condition completed the 56-day self-managed consumer study with 76% of the group reporting their skin felt less itchy, and 75% saying it appeared less red.

Ashman says the findings from the assessment of AxisBiotix-Ps, developed in collaboration with partner Winclove Probiotics, will pave the way for a commercial launch of the product in the fourth quarter.

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SkinBioTherapeutics "delighted" with psoriasis study results, with 76% reporting less itchy skin - Proactive Investors UK

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Psoriasis Therapeutics Market Research Report by Molecule, by Route of Administration, by Dosage Forms, by Mechanism of Action – Global Forecast to…

Posted: at 5:51 am

Psoriasis Therapeutics Market Research Report by Molecule (Biologics and Small Molecules), by Route of Administration (Oral, Parenteral, and Topical), by Dosage Forms, by Mechanism of Action - Global Forecast to 2025 - Cumulative Impact of COVID-19

New York, May 28, 2021 (GLOBE NEWSWIRE) -- Reportlinker.com announces the release of the report "Psoriasis Therapeutics Market Research Report by Molecule, by Route of Administration, by Dosage Forms, by Mechanism of Action - Global Forecast to 2025 - Cumulative Impact of COVID-19" - https://www.reportlinker.com/p05911318/?utm_source=GNW

Market Statistics:The report provides market sizing and forecast across five major currencies - USD, EUR GBP, JPY, and AUD. This helps organization leaders make better decisions when currency exchange data is readily available.

1. The Global Psoriasis Therapeutics Market is expected to grow from USD 16,490.57 Million in 2020 to USD 25,080.12 Million by the end of 2025.2. The Global Psoriasis Therapeutics Market is expected to grow from EUR 14,459.24 Million in 2020 to EUR 21,990.72 Million by the end of 2025.3. The Global Psoriasis Therapeutics Market is expected to grow from GBP 12,854.30 Million in 2020 to GBP 19,549.80 Million by the end of 2025.4. The Global Psoriasis Therapeutics Market is expected to grow from JPY 1,759,961.98 Million in 2020 to JPY 2,676,684.84 Million by the end of 2025.5. The Global Psoriasis Therapeutics Market is expected to grow from AUD 23,946.50 Million in 2020 to AUD 36,419.67 Million by the end of 2025.

Market Segmentation & Coverage:This research report categorizes the Psoriasis Therapeutics to forecast the revenues and analyze the trends in each of the following sub-markets:

Based on Molecule, the Psoriasis Therapeutics Market studied across Biologics and Small Molecules.

Based on Route of Administration, the Psoriasis Therapeutics Market studied across Oral, Parenteral, and Topical.

Based on Dosage Forms, the Psoriasis Therapeutics Market studied across Liquid, Semi-solid, and Solid.

Based on Mechanism of Action, the Psoriasis Therapeutics Market studied across IL blocker, PDE4 Inhibitors, and TNF Inhibitors.

Based on Geography, the Psoriasis Therapeutics Market studied across Americas, Asia-Pacific, and Europe, Middle East & Africa. The Americas region surveyed across Argentina, Brazil, Canada, Mexico, and United States. The Asia-Pacific region surveyed across China, India, Indonesia, Japan, Malaysia, Philippines, South Korea, and Thailand. The Europe, Middle East & Africa region surveyed across France, Germany, Italy, Netherlands, Qatar, Russia, Saudi Arabia, South Africa, Spain, United Arab Emirates, and United Kingdom.

Company Usability Profiles:The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Psoriasis Therapeutics Market including AbbVie Inc., Amgen, Inc., AstraZeneca, Celgene Corporation, Eli Lilly and Company, Johnson & Johnson, and Novartis AG.

Cumulative Impact of COVID-19:COVID-19 is an incomparable global public health emergency that has affected almost every industry, so for and, the long-term effects projected to impact the industry growth during the forecast period. Our ongoing research amplifies our research framework to ensure the inclusion of underlaying COVID-19 issues and potential paths forward. The report is delivering insights on COVID-19 considering the changes in consumer behavior and demand, purchasing patterns, re-routing of the supply chain, dynamics of current market forces, and the significant interventions of governments. The updated study provides insights, analysis, estimations, and forecast, considering the COVID-19 impact on the market.

FPNV Positioning Matrix:The FPNV Positioning Matrix evaluates and categorizes the vendors in the Psoriasis Therapeutics Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape.

Competitive Strategic Window:The Competitive Strategic Window analyses the competitive landscape in terms of markets, applications, and geographies. The Competitive Strategic Window helps the vendor define an alignment or fit between their capabilities and opportunities for future growth prospects. During a forecast period, it defines the optimal or favorable fit for the vendors to adopt successive merger and acquisition strategies, geography expansion, research & development, and new product introduction strategies to execute further business expansion and growth.

The report provides insights on the following pointers:1. Market Penetration: Provides comprehensive information on the market offered by the key players2. Market Development: Provides in-depth information about lucrative emerging markets and analyzes the markets3. Market Diversification: Provides detailed information about new product launches, untapped geographies, recent developments, and investments4. Competitive Assessment & Intelligence: Provides an exhaustive assessment of market shares, strategies, products, and manufacturing capabilities of the leading players5. Product Development & Innovation: Provides intelligent insights on future technologies, R&D activities, and new product developments

The report answers questions such as:1. What is the market size and forecast of the Global Psoriasis Therapeutics Market?2. What are the inhibiting factors and impact of COVID-19 shaping the Global Psoriasis Therapeutics Market during the forecast period?3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Psoriasis Therapeutics Market?4. What is the competitive strategic window for opportunities in the Global Psoriasis Therapeutics Market?5. What are the technology trends and regulatory frameworks in the Global Psoriasis Therapeutics Market?6. What are the modes and strategic moves considered suitable for entering the Global Psoriasis Therapeutics Market?Read the full report: https://www.reportlinker.com/p05911318/?utm_source=GNW

About ReportlinkerReportLinker is an award-winning market research solution. Reportlinker finds and organizes the latest industry data so you get all the market research you need - instantly, in one place.

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Fish Pedicure: Risks, Benefits, Safety, and Ethical Concerns – Healthline

Posted: at 5:51 am

A fish pedicure involves dipping the feet into a basin of water filled with fish. These fish, Garra rufa, sometimes called doctor fish, eat the dead skin off the feet revealing smooth, callous-free skin, and cleaner-looking cuticles.

Fish pedicures are popular in Turkey, where they originated, and other Middle Eastern countries. Garra rufa fish are native to the Middle East and Southeast Asian countries. They are allowed in certain places in the United States.

The procedure became popular because the fish are able to exfoliate and soften the feet in a non-painful way. The fish pedicure tickles but does not hurt. However, these pedicures pose both health and environmental risks, and are actually banned in many U.S. states and parts of Canada and Europe.

There are several reasons fish pedicures may be considered risky or unsafe. Here are the safety concerns of fish pedicures:

The purported benefits of fish pedicures include reduced callouses, smooth skin on the feet, and exfoliation of dry skin and rough patches. A pedicure done by a human from a trusted salon will do the same, however, and so will at-home use of a pumice stone or a foot scrub. The risks of fish pedicures outweigh the benefits.

One study found a 72 percent reduction of psoriasis in people undergoing ichthyotherapy, or using Garra rufa to treat conditions, though there are other treatments that dont carry risks.

At least 14 states have banned fish pedicures, including:

They are also banned in Mexico, parts of Europe, and parts of Canada.

There are also ethical concerns associated with fish pedicures.

Fish pedicures at a salon involve putting the feet in a basin of water filled with Garra rufa, a fish native to the Middle East. The purported benefits are smoother feet and potentially less psoriasis, but the safety and ethical concerns including potential for infection and lack of sanitation between customers outweigh the benefits.

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Fish Pedicure: Risks, Benefits, Safety, and Ethical Concerns - Healthline

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The ‘Skinification’ Of Hair Care – HAPPI – happi.com

Posted: at 5:51 am

For years, I have been telling my patients your scalp is skin, so treat it well. Now, we are witness to a skinificaton of hair products and it is all because the scalp is a very important part of the hair growth process.

Healthy hair cannot be produced without a healthy scalp. The scalp skin is an extension of internal and external health. As I noted in a previous column (January 2020) the gut microbiome affects the skin microbiome which, in turn, affects the scalp microbiome, and therefore hair growth. Since 2020, we have witnessed the burgeoning of scalp care products with CBD formulations, products boasting microbiome benefits, and scalp serums and solutions for flaking, itching and tension. So, what is this all about? Lets dig into the science.

The surface of human skin is a site of microbial colonization. The commensal flora of the skin maintain a symbiotic relationship and shape the cutaneous immunity of the host. Several studies have characterized the cutaneous bacterial communities of healthy individuals and patients with inflammatory diseases, mostly in material collected using swabs. Sampling from hair follicle (HF) openings is challenging. Along their epithelium, HFs harbor a multitude of microorganisms able to reach deeper compartments, frequently organized in biofilms. The role of bacteria as disease-aggravating factors has been recognized for HF-associated inflammatory diseases such as acne vulgaris or folliculitis decalvans, an inflammatory, scarring hair loss.

Scalp hair follicles form large tubular invaginations, which extend deeply into the skin and harbor a variety of microorganisms. A single square centimeter of human skin, along with adnexal structures, such as sweat and oil glands, can be inhabited by up to one billion microorganisms including bacteria, fungi and viruses, forming a complex community known as the skin microbiome.

The scalp includes 100,000150,000 hair follicles (HFs); for comparison, the human body has about five million HFs. These follicles are formed during embryogenesis and ensure cyclic hair growth throughout ones lifetime. Those on the scalp contribute to a significant increase of skin surface area and, more importantly with regard to colonization, form pockets along the infundibulum, which extend into deeper scalp skin layers. The infundibulum is the upper portion of the hair follicle. It begins at the surface of the epidermis and extends to the opening of the sebaceous duct (where scalp oil is secreted). The infundibulum is typically filled with sebum, debris and microorganisms ranging from viruses to bacteria, as well as yeasts/fungi and even mites.

There is increasing proof of the presence of bacteria reaching below the skin surface and along the HFs, and evidence is emerging that the cross-talk between bacteria and the underlying tissue is a dynamic reciprocal process. External microbial stimuli create immunological responses across the HF epithelium, but events in the tissue also shape microbial composition. Along the infundibular HF epithelium, microorganisms find themselves in a highly immuno-active environment. In contrast to the massive exposure to microbial material in its upper part, immuneprivileged sites are found around the hair bulge and the anagen bulb. The bulge contains several epidermal stem cells. A collapse of the immune privilege is a key element in the pathogenesis of chronic scalp diseases. Numerous immune cells are deployed in the skin and around its appendages in close proximity to microbiota. Commensals are considered essential to maintain skin homoeostasis. They protect the skin from its colonization by pathogens, stimulate production of the complement system and cytokines involved in the initiation and maintenance of an immune response. Furthermore, microbiota help decrease the magnitude of inflammation and promote tissue repair.

Acne and primary scarring alopecias are good examples of how the local follicular microenvironment; e.g., hypoxic conditions and lipid substrates, resident microbes and their metabolic products, can influence inflammatory and antimicrobial processes in the skin.

The skin surface and follicular openings are recognized sites of rich microbial colonization and intense immune activation, with cross-talk across the skin barrier. The bacterial microbiome extends below the infundibulum, with the confirmed presence of various species and high abundance of Corynebacterium and Staphylococcus. It is in close proximity to structures of the immune privileged status, which are essential for the hair cycle.

Several preliminary studies suggest that external stimuli may affect the state of activation of the HF immune system. Lower sections of the HF are protected from immune cell infiltration under healthy conditions, the so-called immune-privileged areas. This includes the bulge, where a stem cell niche is found, and the bulb, where cells divide and grow to build the new hair. However, both regions are sites of intense inflammatory infiltrate in inflammatory hair diseases like primary cicatricial alopecia and alopecia areata. Alterations in the HF microbiome or the penetration depth of microbial material could be related to homeostasis, modulation of cutaneous immune reactions and inflammatory processes along the HF. The localization of this involvement with the immune system is critical, affecting the possibility of regrowth after subsidence of inflammation. When the stem cell niche is attacked, like in cicatricial alopecia, patients suffer permanent, scarring hair loss. On the other hand, AA pathogenesis involves inflammation of the peribulbar region, allowing a possible hair regrowth.

The strongest evidence supporting correlations with microorganisms colonizing the scalp has been found in seborrheic dermatitis/dandruff and in a type of inflammatory cicatricial alopecia named folliculitis decalvans (FD). An antimicrobial treatment administered in these diseases brings transient success in most cases. However, frequent recurrences, lack of efficacy in some patients and the additional need of antiinflammatory therapy in acute flareups, indicate the complexity of their pathogenesis.

Androgenetic alopecia (AGA) features shortening of the anagen phase and eventually, a slowly progressing miniaturization of the hair follicle. Infiltration of mononuclear cells and lymphocytes is detected in about 50% of skin samples. This microinflammation takes place in the upper third of the HF, where a great number of microorganisms are harbored. Moreover, the production of complement (inflammatory mediators), were identified in the pilosebaceous duct of 58% of patients with AGA compared to 12% of the control group. These arguments together with observed improvement after application of antimicrobial agents may suggest a possible connection with scalp microflora.

In scalp psoriasis, the rate of positive cultures of Malassezia species was higher in psoriatic scalp lesions compared to healthy controls. Changes of the scalp microbiome were found to depend on disease severity. GomezMoyano et al. identified M. restricta as the most frequent in mild scalp psoriasis, and M. globosa in moderate, and severe cases, and in patients with exacerbation in the last month. Cases of refractory scalp psoriasis successfully treated with imidazole, followed by reduction of yeasts, were presented and support the theory of a role of Malassezia as an exacerbating factor in scalp psoriasis. Furthermore, alterations in the composition of gut microbiome have been observed in patients with psoriasis.

A possible connection between colonization of the scalp by Alternaria spp. and Alopecia Areata (AA) development was postulated. Fungi of this genus were cultured from epidermal scrapings in 20% of patients compared to 13.3% of controls. Not only skin but also gut microbiome has recently been considered to be associated with AA. An increased intestinal permeability due to dysbiosis and/or inflammation may be an underlying stressor of the immune system in genetically susceptible individuals.

Low production of short chain fatty acids by intestinal bacteria as a result of insufficient intake of fibers in the Western diet is likely disadvantageous to the intestinal barrier and function of the colon. This further supports the idea that a healthy gut is important in maintaining healthy skin and hair.

There is a greater prevalence of atopic dermatitis in patients with AA compared to population prevalence. Atopic dermatitis is associated with more severe course of AA. The defective skin barrier in atopic dermatitis may ease microbial penetration to deeper follicular compartments, possibly aggravating or causing alopecia areata.

So why the skinification of hair care? The aforementioned diseases of the skin and the HFs are all due to dysfunctions of dysbiosisthe imbalance of the skin microbiome. Skin barrier dysfunction translates into scalp barrier dysfunction, leading to inflammation and hair loss as evidenced by the link between eczema and more severe alopecia areata.

Just as it is important to maintain the skin barrier with ceramides and lipids, it is important to maintain the scalp barrier as well with scalp and hair care products that mimic skin care products. It only makes sense, as the scalp is a continuation of the skin. There is no line of demarcation separating bodily skin from scalp, so why not care for your scalp as you do for your skin?

References

Dr. Sharleen St. Surin-Lord is a board-certified dermatologist who has been practicing for more than 13 years. She is in private practice at Visage Dermatology, Largo MD. She also practices at the University of Maryland Capital Regional Health System in Maryland and she is an assistant professor of dermatology at Howard University College of Medicine. Dr. Sharleen is a member of the American Hair Research Society and you can follow her on Twitter, Instagram, and Facebook as DermHairDoc.

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The Supercar/Hypercar Wars Continue, But The Roadster Still Has An Ace Up Its Sleeve – CleanTechnica

Posted: at 5:50 am

When the Tesla Roadster was revealed, it was quite a surprise. People thought the Tesla Semi reveal was over and that everyone was going to head home soon. Suddenly, the lights changed and the prototype came out of the back of a Semi like the DeLorean in Back To The Future came out of Doc Browns van.

It turned out that Tesla had not only the showmanship for the reveal down, but a vehicle built to back it. The fastest acceleration times, great top speeds, and over 600 miles of range (obviously not at top speed, of course) made for a big change in the supercar world. The companies making cars that sell for millions found much of their performance looking weak next to a car that would sell for far, far less. It indeed could give a hardcore smackdown to gas-powered cars.

If we compare the Roadster reveal to the destruction of the Death Star in Star Wars Episode IV, what were seeing now is Act II of the play, where the baddies strike back (like, you know, The Empire Strikes Back). Thats the part of the play where the heroes often end up in a bind again. Obviously, ICE cars dont have The Force (in the auto world, we call this massive low-end torque) that Tesla does in terms of raw acceleration, which puts them at a big disadvantage, but they still have some tricks up their sleeve.

Lamborghini says they arent even going to focus on getting the best 0-60 times, and will instead get a competitive advantage through better handling. As I pointed out in this article, this is a real threat to any dominance Tesla may gain with the 2G Roadster. Sure, the Roadster will beat almost anything the supercar makers can throw at the drag strip, but on other types of tracks, handling will matter a lot more.

While we dont yet know the curb weight, it seems very unlikely that it will weigh less than 3000 pounds. The battery alone will be around 2000, and with everything else the vehicle needs, 35004500 pounds is a reasonable range.

Contrast this with cars like the Gordon Murray T50. Not only will the car weigh around half what the 2G Roadster will, but it will also have an active fan system that suctions the vehicle down to the road like the legendary Chaparral 2J. With this weight advantage, plus technology that was banned from most forms of racing because the vehicle was too good, the advantages of more modern engine technology is going to give that car a shocking handling advantage over the 2G roadster.

This really shows us where the supercar industry is going. Everyone is making their vehicles lighter, with better handling, and more top-end power than ever before.

In other words, they cant beat the Roadster on acceleration, so theyre stepping up their game in places where the Roadster is currently the weakest. But will that last?

In response to all these recent supercar developments, Mercedes-Benzs performance division, AMG, is going to do something truly wild. Theyre basically taking a Formula 1 racer, Making the minimum changes it takes to make it road legal, changing it a bit more to make it street drivable, and selling it. Theyre calling this beast the Mercedes-AMG ONE.

Image by Mercedes-Benz AMG.

The plug-in hybrid car has a modified F1 engine, plus 4 electric motors. Three of the cars motors drive the wheels directly, with two in the front (one for each wheel), and one in the rear tied to the gas engine to drive the rear wheels. The fourth electric motor is part of a turbocharger system, and can either use electricity to push more air into the engine or generate electricity from exhaust gases. While these motors would serve in a support role during racing, the vehicle can drive for 16 miles on electric only.

The gas engine itself is about as wild as they come. Its displacement is only 1.6 liters, spread out over six cylinders. It wont rev up to 11,000 RPM like a Formula 1 car, because they couldnt sell a vehicle with an engine that only lasts a couple thousand miles, but it will still have impressive abilities for the track.

Final figures arent out yet, but expect superior handling and loads of top-end power for the straight sections of the track.

At this point, the reasonable readers are wondering who would win, while the Stans are 100% sure the Roadster would still beat it. As it turns out, youre both right.

At a drag strip? Tesla all the way. The F1 engine and limited electric power wont propel the AMG ONE from 060 mph or through a straight-line quarter mile the way Teslas monster EV system will. For racing without sharp turns, the Tesla will be hard to beat with anything but other upcoming electric supercars (and those are coming, too).

On a track with lots of curves, though, the ONE will either run very competitively or be the one doing the smackdowns. Its all going to come down to the layout of the track.

On something like the Nordschleife, expect the Tesla to initially pull ahead because of its superior low-end acceleration. Once they get to the turns, though, the Roadster will lose ground and start to fall behind. A vehicle thats 1,000 to 1,500 pounds lighter and still has the benefits of electric torque vectoring just wont be beat by a heavy EV here unless they completely botch the suspension design. Given that its a modified F1 car, expect this to not be the case, and expect it to romp all over in the curvy sections.

What happens in the longer straightaways is still an open question that will decide the race first. Tesla says the Roadsters top speed is over 250 mph, and AMG says its car will go more than 217 mph. Those are both open-ended figures, and not actual top-speed figures, so its possible that either car will have a greater top speed. Either way, wed see the Tesla take back ground in the straights initially, at least until the F1 engine can get to screaming and possibly give the AMG the advantage.

The Tesla will have to start braking before the other supercars, though, when the straightaway ends. Thats going to take away part of the gains it made (if any) in the straight sections.

The above comparison also leaves out any potential magic from SpaceX thrusters.

Bottom line here: we dont know who will win here.

For the Mercedes-AMG ONE, there are still going to be some major downsides, though.

The biggest one is the price, which will approach $3 million. Thats 1015 the price of the Roadster, so that extra little edge that could beat the Roadster on some tracks comes at quite a price. On top of that, the engine will only be designed to run for 30,000 miles. This is impressive, because the real F1 race engines only last 2,000 miles at most, but thats going to add to the expense of owning one.

Expect some owners to try to do a lot of casual driving on electric so they dont wear out the racing engine.

The price advantage probably wont hold in the long run, though. The Gordon Murray T50 will be almost a million bucks cheaper than the Mercedes-AMG ONE, and we can expect supercar technology to slowly trickle down to the cheaper sports cars.

One likely contender that could give the Roadster a challenge for a similar price is the upcoming Corvette E-Ray. Specs are all rumor at this point, but some expect to see a hot turbocharged version of the cars mid-mounted V8 gas engine that produces 900 horsepower alone. Add two front electric motors, and youd have a machine that will make buyers think about their options.

Another indicator that hybrid supercars will continue to compete comes from Honda. The NSX has been out a few years, and many people were initially disappointed with its performance. When people started giving them upgrades and tunes, though, the NSXs got to the point where they werent far behind a Raven Tesla on the drag strip. We can expect to see more affordable sporty hybrids come out in the same price range as the Roadster with even better performance.

Nissan is also stepping up its attack specifically the GTR N Attack package. The price of the GTR plus all of the N Attack upgrades would give you a vehicle thats capable of approaching 7 minutes at the ring for a price thats close to that of the Roadster. Thats a little faster than the modified Plaid Model S Tesla ran on the same track.

If the emerging competition is like The Empire Strikes Back, the second act where the heroes are in peril, then something else we recently learned is going to be the equivalent of The Return of the Jedi. It turns out that a trick Elon Musk had up his sleeve wasnt just a good card, but all four aces.

As my colleague Johnna pointed out, we recently got more information about the upcoming Roadster SpaceX package. We already knew that they intended to offer one with cold gas thrusters that shoot compressed air to push the car, but what we didnt know was that it could achieve 0-60 mph in just over 1 second with that option. Thats an insane amount of acceleration, and can happen independently of speed because the thrusters are not coupled to the drivetrain.

Sure, 060 mph times arent a help against the competition, which is now focusing on the Roadsters weak spot, but it seems likely that there will be more thrusters that allow for lateral force that could cancel out inertia in corners (even if the occupants would feel queasy afterward). Plus, getting a quick burst of power when exiting turns, or a quick burst of acceleration to execute a pass, will likely more than level the playing field.

Add the possibility of using the thrusters for downforce and/or short hops, and you take the 2D racetrack and play 3D chess. Will tracks/events allow you to literally leapfrog the competition? Even if they dont, its still really intimidating to know that the vehicle could do that and that its only the rules thats saving you from utter defeat.

Im not sure what the competition could pull out to fight that, but I doubt theyll just call it quits. Its great that Tesla is still doing things to push the industry forward into new territory and keep competition strong well into the future.

Featured image by Tesla.

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Ignyte Acquisition Corp. Receives Notification of Deficiency from Nasdaq Related to Delayed Filing of Quarterly Report on Form 10-Q – Yahoo Finance

Posted: at 5:50 am

Ignyte Acquisition Corp. (NASDAQ:IGNYU) (the "Company") today announced that on May 28, 2021 it received a notice from Nasdaq Regulation indicating that, as a result of not having timely filed its Quarterly Report on Form 10-Q for the period ended March 31, 2021 (the "Form 10-Q"), the Company is not in compliance with Nasdaq Listing Rule 5250(c)(1), which requires timely filing of all required periodic financial reports with the Securities and Exchange Commission (the "SEC").

The Nasdaq notice has no immediate effect on the listing or trading of the Companys units, Class A ordinary shares or warrants on the Nasdaq Capital Market. The Notice provides that the Company must submit a plan to regain compliance with Nasdaq Listing Rule 5250(c)(1) by July 26, 2021. If the plan is accepted by Nasdaq, then Nasdaq can grant the Company up to 180 calendar days from the due date of the Form 10-Q, or November 22, 2021, to regain compliance.

As the Company reported in its Form 12b-25 filed with the SEC on May 17, 2021, the Company is working diligently to complete the Form 10-Q as soon as possible; however, given the scope of the process for evaluating the impact on the Companys financial statements of the Staff Statement on Accounting and Reporting Considerations for Warrants Issued by Special Purpose Acquisition Companies ("SPACs") issued by the staff of the SEC on April 12, 2021, the Company is not in a position to file the Form 10-Q until after the completion of this process.

This press release contains statements that constitute "forward-looking statements." Forward-looking statements are subject to numerous conditions, many of which are beyond the control of the Company, including those set forth in the Risk Factors section of the Company's registration statement and prospectus for its initial public offering filed with the SEC. The Company undertakes no obligation to update these statements for revisions or changes after the date of this press release, except as required by law.

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View source version on businesswire.com: https://www.businesswire.com/news/home/20210601005937/en/

Contacts

David RosenbergCo-Chief Executive OfficerIgnyte Acquisition Corp.drosenberg@ignytespac.com

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Ignyte Acquisition Corp. Receives Notification of Deficiency from Nasdaq Related to Delayed Filing of Quarterly Report on Form 10-Q - Yahoo Finance

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Why SoFi’s dealmaking CEO went the SPAC route for its IPO – Yahoo Finance

Posted: at 5:50 am

SoFi's (SOFI) long-awaited IPO on Tuesday isn't the first time CEO Anthony Noto has had a splashy deal day.

Noto is a former tech analyst and investment banker at Goldman Sachs who spent more than 12 years at the firm (1999 to 2008, then a return from 2010 to 2014 after a stint in between as the NFL's CFO). He played a key role in Twitters IPO while at Goldman he then joined CEO Jack Dorsey at the company as chief operating officer for an almost four-year period.

Given that extensive dealmaking experience and the uncanny sense of the market that comes with it it should't be a surprise that Noto opted for a clever SPAC transaction to finally bring SoFi public.

"The vehicle for us [SPAC] was a unique way for us to achieve private capital and have certainty of the deal closing, and in addition to going public and having it all in one packaged product," Noto said on Yahoo Finance Live. "We had a unique circumstance in that we had a significant amount that was preferred stock and the IPO wasn't the most easiest and cost efficient way to convert the preferred into common stock, which was necessary for us to apply for a bank license and to be able to go public."

SoFi essentially merged Tuesday with blank check company Social Capital Hedosophia, backed by well-known venture capital investor and SPAC fan Chamath Palihapitiya.

But since SoFi announced the transaction back in early January, SPACs have come under considerable fire from investors and regulators for their skirting of the transparency inherent to a traditional IPO process. The company's that have arrived to market via SPAC have also been attacked for their eye-popping losses, suspect disclosures and insane forward-looking projections (see electric vehicle maker Lordstown, for example).

And investors have made their concerns about SPACs heard.

The SPAC and New Issue ETF (SPCX) an investment vehicle that invests most of its net assets in SPACs has plunged 15% from its late February record high. Individual companies that have come to market via SPAC in recent months have fallen even harder for instance, electric vehicle maker Nikola (a 2020 SPAC) has crashed 46% from its latest January high amid concerns on its viability from short-seller Hindenburg Research.

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"I think with the evolution of any new financing vehicle there is a cycle that ensues where there is a lot of interest in that cycle and you have a broad-based number of participants that come in. And then there is often a shakeout. Ultimately quality emerges from that shakeout, and it becomes more narrow of an opportunity that will persist over time," Noto explains of the 2021 SPAC sell-off.

LOS ANGELES, CALIFORNIA - SEPTEMBER 15: SoFi CEO Anthony Noto looks on before the game between the Los Angeles Rams and the New Orleans Saints at Los Angeles Memorial Coliseum on September 15, 2019 in Los Angeles, California. (Photo by Sean M. Haffey/Getty Images)

SoFi has several things in its favor unlike other recent SPACs, which probably explains why the stock spiked 7% in its trading debut Monday.

First, is an experienced executive team run by Noto. Two, is a credible board of directors with a mix of tech and investment banking experience. The SoFi board will soon be getting a knowledge boost via the arrivals of Noto friends in former Goldman Sachs president and COO, Henry Schwartz, and former Twitter CEO Dick Costolo.

And finally, SoFi has a real business that is delivering actual financial results in 2021 as Noto has expanded into stock investing, crypto investing, IPO investing and other financial services since arriving as CEO in 2018. Previously, SoFi was just known as a school loan refinancer.

SoFi's first quarter sales rose 151% year-over-year to $216 million. The company posted its third straight quarter of adjusted EBITDA [earnings before interest, taxes, depreciation and amortization] profits. The number of members on the platform have grown at an accelerated growth rate for seven consecutive quarters.

For 2021, SoFi forecasts sales of $980 million and adjusted EBITDA of $27 million.

Brian Sozzi is an editor-at-large and anchor at Yahoo Finance. Follow Sozzi on Twitter @BrianSozzi and on LinkedIn.

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The economy will probably overheat this summer: top strategist – Yahoo Finance

Posted: at 5:50 am

TipRanks

When the best talk, people listen. It works in all walks of life, but especially the stock market. Investors are keen to read the latest stock reviews from Wall Streets professional analysts, but knowing whos the best is the place to start. Covering the markets for investment firm and brokerage Oppenheimer, Colin Rusch has built a reputation that puts him at the top of the Streets analyst corps. Hes currently rated #7 overall by TipRanks, out of more than 7,500 analysts offering regular coverage of the markets. Ruschs ranking is based on more than 400 published reviews, that have accumulated a 63% success rate and an investor following Ruschs recommendations in the past year would have seen a 64% average rate of return. So, lets catch up with some of Ruschs recent stock notes. Using the TipRanks platform, weve looked up two calls of his and two factors popped out right away: these are Buy-rated stocks with more than 100% upside potential for the year ahead. And for the retail investor, seeking a bargain in the markets, the low point of entry sweetens the pie; each of these stocks is trading for less than $10 per share. Here are the details. Aeva Technologies (AEVA) Well start with Aeva Technologies, a company working in the field of perception and sensing technology an essential field in the autonomous automobile industry. Aevas main project is the development of 4D LiDAR-on-chip, an achievement which will turn sensing systems on their head by combining silicon photonics, precision velocity measurement, and long-range performance. The resulting package will enable faster and more accurate sensing in driverless vehicles, for better detection and avoidance of obstacles, whether stationary of mobile. Success in this endeavor will give Aeva a clear path forward to success in the autonomous car field. Back in March, Aeva entered the public trading markets through a SPAC transaction with InterPrivate Acquisition. The merger completed on March 15, and AEVA shares started trading on the NASDAQ on that day. In sharp contrast to last year, SPACS have generally had a hard time in 2021s stock market, and so has Aeva; the shares have slipped since the public debut. However, AEVA stock hit its trough in mid-May and has been regaining value in the last couple of weeks, after the company released its 1Q21 earnings results the first as a publicly traded entity. At the top of the earnings release, Aeva announced that its SPAC merger had netted the company $513 million, and that it had $523 million in cash reserves available at the end of Q1, compared to just $24.6 million at the end of 2020. In a key development update, Aeva revealed that its third generation LiDAR chip is in its final architecture and has integrated all of the core LiDAR components. The company is engaged in setting up production lines for the new chip. In his coverage of AEVA shares, Colin Rusch writes, AEVA continues to make tangible progress toward commercializing its FMCW-based 4D lidar announcing its ability to offer 500m range on existing hardware via a firmware upgrade. We believe the flexibility and potential future proofing of systems enabled by its software defined architecture combined with the velocity information is critical for its customers and the potential for product improvement during its useful life. We are encouraged by AEVA delivering its Gen 3 chip design ahead of schedule. We continue to see AEVA as a long-term winner in the lidar and autonomous space Rusch rates this stock as Outperform (i.e., a Buy), and his $20 price target implies it has room for 104% growth in the next 12 months. (To watch Ruschs track record, click here.) Wall Street generally is even more bullish here than Rusch is. The Strong Buy analyst consensus rating is unanimous, based on 5 recent reviews, and the $23.40 average price target suggests a robust 139% upside potential from the trading price of $9.76. (See Aevas stock analysis at TipRanks.) Aqua Metals (AQMS) Our modern world has brought us technological marvel but also an enormous level of industrial pollution. Among the worst pollutants is lead. Lead has been used in a wide range of products, most notably in pipes and batteries, from which it can leach into the environment and then into us where its toxic effects are proven dangerous. This makes lead one of the most recycled materials in the world today. Aqua Metals specializes in clean recycling technology for lead acid batteries. The company uses its proprietary AquaRefining process a water-based, room temperature lead refining process that is non-polluting to replace the current system of high-temperature lead smelting. Such lead smelting is one of the worlds most polluting industries. Aqua Metals has a huge potential market, as some 80% of the lead used in the battery industry is recycled. While dangerously toxic, these batteries are going to be with us for at least the foreseeable future, as lead acid batteries are also the only 100% recyclable and rechargeable batteries on the market. The company is working to expand its niche, and it has applied, earlier this year, for patents in the field of lithium ion battery recycling. Where lead acid batteries are heavily used in industrial applications, lithium ion batteries are ubiquitous in electronics and they contain of host of other toxic metals, such as cobalt, nickel, and manganese. Aqua Metals hopes to apply its refining technology to these batteries, as well. Aqua Metals processes are not yet in operational use, and so the company has no revenues and earnings to speak of. In the first quarter of 2021, Aqua Metals reported a net loss of $4.1 million, coming to 6 cents per share, compared to the $4.4 million, 7-cent per share, net loss reported in the year-ago quarter. Also in 1Q21, Aqua Metals invested $1.5 million in the LINICO Corporation, another cleantech company in the lithium ion battery recycling niche. Rusch is bullish on this speculative company, writing of it, We continue to believe AQMS' closed loop zero-emissions process technology for recycling lead is a critical enabler for portions of the battery supply chain to reach net-zero emissions and has the potential to become the de facto standard process for recycling lead as the world moves toward net-zero commitments in 2040. We are looking at the announcement of a license and equipment supply agreement as the next, and critical, validation of the business model. The 5-star analyst gives AQMS an Outperform (i.e., Buy) rating, along with a $7 price target that implies a one-year upside of 147%. Both recent reviews on AQMS shares are positive, giving the stock its Moderate Buy consensus rating. The trading price is $2.83, and the average price target of $7.50 suggests a strong 165% upside from that level. (See Aqua Metals stock analysis at TipRanks.) To find good ideas for stocks trading at attractive valuations, visit TipRanks Best Stocks to Buy, a newly launched tool that unites all of TipRanks equity insights. Disclaimer: The opinions expressed in this article are solely those of the featured analysts. The content is intended to be used for informational purposes only. It is very important to do your own analysis before making any investment.

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The economy will probably overheat this summer: top strategist - Yahoo Finance

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When is an economy overheating: Yahoo U – Yahoo Finance

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For more business and finance explainers, check out our Yahoo U page.

Can an economy pop from too much stimulus? Thats the concern behind overheating, a term thats been the center of economic debate as the $20 trillion U.S. economy re-opens and recovers from the COVID-19 pandemic.

With trillions in stimulus coming from both the federal government and the U.S. central bank, some are concerned that the economy will grow too fast and spur unwanted levels of price inflation.

As Treasury Secretary Janet Yellen once said, expansions dont die of old age.

Overheating is one way for an economic expansion to end. There is no official economic definition for overheating. But one oft-cited indicator of overheating is inflation, or rising prices.

In a healthy economy, unemployment should fall (as people find jobs) and GDP should rise (as economic activity grows). Employed and with income, consumers will demand goods and services.

Producers may adjust prices to capitalize off of the increased demand (and pay for any associated increases in production). In turn, employees of those producers may ask for pay raises that net them more income. Those households can then demand more goods and services, rounding the cycle of wages and prices.

An illustration of a wage-price spiral.

In an overheating economy, this loop repeats several times, leading to rounds of markups in prices and fueling runaway inflation. The so-called wage-price spiral was one of the factors in double-digit price inflation in the 1970s, the most notable example of economic overheating.

Runaway prices can quickly erode the purchasing power of a household. But its not the inflation itself that causes a recession.

To tame the hyperinflation beast, then-Federal Reserve Chairman Paul Volcker dramatically lowered the money supply and ratcheted up short-term borrowing costs, triggering a sharp pullback in economic activity.

The worry is that runaway inflation will again force the Federal Reserve to pump the brakes to dampen inflationary pressures, raising interest rates in a way abruptly ends the recovery.

Story continues

Economists have different definitions on what level of inflation constitutes overheating.

One challenge is parsing out true inflationary pressures from those that may be temporary or transitory.

If inflation is rising because of short-term constraints that are likely to fade in a few months, high inflation readings may not be of much concern to policymakers.

But if inflation is due to the wage-price spiral, a deeper, more entrenched dynamic may be at play.

This is why it is difficult to say that a reading of 4% or 5% year-over-year inflation means overheating, since it is all about the persistent nature of the price pressures leading to those readings.

Fed officials have leaned into the transitory side of the debate, saying they expect inflation readings to rise as a result of measurement effects and bottlenecks in the international supply chain.

The Bureau of Economic Analysis publishes the Personal Consumption Expenditures Index, a major source of inflationary data. Since the last crisis, year-over-year inflation in the PCE index have been low compared to growth rates seen in decades before that. Source: Bureau of Economic Analysis

The Fed has also taken note of the fact that inflation has been persistently low since the last crisis, which explains their new framework that will tolerate inflation moderately above its 2% target.

In other words, high monthly inflation readings in the early months of the pandemic recovery are not of immediate concern to policymakers.

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Two New Stimulus Checks May Be on the Way Heres Everything You Need to Know – Yahoo Finance

Posted: at 5:49 am

Evgenia Parajanian / Getty Images/iStockphoto

More and more support has been developing for a fourth and possible fifth stimulus check amongst members of Congress.

See: $1,400 Stimulus May Be on the Way This Time From Your StateFind: New Stimulus Perk Helps Pay for Your WiFi and Laptop

In a new letter to President Joe Biden, seven members of the influential Ways and Means Committee have joined fellow members of Congress who support additional stimulus checks.

It claims that that the American Rescue Plans checks alone will keep 11 millions people out of poverty this year, with unemployment insurance expansion and other provisions in the bill accounting for another five million people.

A fourth and fifth stimulus check could keep an additional 12 million out of poverty, the legislators claim. They also stated that the combined effects of Bidens new bill and new stimulus checks could reduce the number in poverty this year from 44 million to 16 million.

The lawmakers defended their request for more stimulus money saying that not only do the checks help keep families and workers out of poverty, but they act as an economic stimulus by increasing spending and supporting jobs.

However, new reporting by the Boston Herald released yesterday might weaken this particular argument. Through data obtained from Internal Revenue Service records, they reported that a staggering 1.24 million stimulus checks remain unspent from the first coronavirus-era bailout. That is an estimated $1.7 billion unaccounted for based on the max $1,200 per household that was distributed.

See: Child Tax Benefits Will Start Hitting Accounts July 15Find: Student Debt Forgiveness Dropped From Bidens Annual Budget

The unspent checks are not lingering bank accounts though; they are from people who either refused to accept, paid back or not cashed the stimulus checks they received from the IRS as a result of the CARES Act that was signed into law on March 27, 2020, according to the data provided from the IRS.

Story continues

The Boston Herald noted that the IRS data shows California as leading the country with 123,265 stimulus checks left unspent, Florida coming in second with 92,018 checks and Texas, New York and Pennsylvania rounding out the top five.

The Committee for a Responsible Federal Budget took a different stance. They stated their data, which is based on Congressional Budget Office estimates, concludes that some of the money has not been spent due to slow or low demand and that data is either publicly unavailable or has a long lag time.

This combined information could hinder a push by legislators to put two more stimulus checks on the table, as the data could suggest that the checks are being utilized as more of a safeguard rather than a necessity to uplift the economy.

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Two New Stimulus Checks May Be on the Way Heres Everything You Need to Know - Yahoo Finance

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