Daily Archives: May 31, 2021

CF Foundation Funds Three New Research Awards to Advance its Path to a Cure Initiative – Business Wire

Posted: May 31, 2021 at 2:44 am

BETHESDA, Md.--(BUSINESS WIRE)--Today, the Cystic Fibrosis Foundation announced three new research awards as part of its Path to a Cure initiative to accelerate the development of treatments for the underlying cause of cystic fibrosis for every person with the disease. The latest round of funding includes up to $2.6 million to Eloxx Pharmaceuticals to identify compounds that could potentially treat individuals who have nonsense mutations, as well as awards to Hunterian Medicine and Metagenomi to advance genetic therapies for all people with CF.

Focus on Nonsense Mutations

Under this latest funding agreement, Eloxx will screen its library of more than 2,000 compounds to identify potential readthrough agents to address CFTR nonsense mutations, also referred to as stop mutations, which cause cells to stop the production of the CFTR protein prematurely. Readthrough agents have the potential to enable the ribosome -- the protein-making machinery of the cell -- to read through premature stop signals so that a full-length CFTR protein can be made. Once identified, the compounds will go through chemical testing to select those that can be developed into drugs.

In anticipation of future clinical trials, Eloxx will screen for candidates that could work in people with CF who have at least one G542X mutation, the most common nonsense mutation in CF. If proof-of-concept studies are successful, the compound could be used for other nonsense mutations. In January, the Foundation also funded up to $2 million to Eloxx to support the global Phase 2 clinical program of a more advanced compound, ELX-02, for treatment of people with CF who have at least one G542X mutation.

Nearly 4,000 people with CF in the U.S. have one or more nonsense mutations, which are challenging targets for drug discovery and development. Beyond CF there are more than 1,800 diseases caused by nonsense mutations, virtually all of which have eluded researchers seeking FDA-approved therapies. The Foundation is pursuing treatments for people with nonsense mutations -- who are still waiting for a breakthrough because their mutations are not responsive to modulators -- in parallel with its efforts to advance potentially curative approaches that could address all genetic mutations.

We feel great urgency to identify therapies that target nonsense mutations as we pursue our ultimate goal of a cure for every person with CF, said William Skach, MD, executive vice president and chief scientific officer for the Foundation. The early stage research underway at Eloxx complements other Foundation-funded screening programs for nonsense mutation treatments and bolsters our scientific knowledge of these notoriously difficult-to-treat targets.

Advancing Genetic Therapies

Genetic therapies hold great promise to cure cystic fibrosis, but delivering these therapies in CF is more challenging because of the lungs natural defense mechanisms. Fitting large genes, such as CFTR, inside the adeno-associated viruses that are the standard for gene delivery, is another obstacle that will require novel solutions.

To help develop those solutions, the Foundation awarded up to $600,000 to Metagenomi to identify and develop novel gene editing systems that are small enough to be delivered to lung cells and could potentially be applied to a variety of mutations.

In addition, Hunterian Medicine was awarded up to $300,000 from the Foundation to modify gene therapy components so a healthy CFTR gene can be delivered to lung cells. Hunterian has identified very small promoters that control expression of the gene and will use CF Foundation support to conduct preclinical lab tests to choose the promoter that works best in cells lining the lungs.

About the Path to a Cure

The CF Foundation launched its $500 million Path to a Cure initiative in October 2019. This initiative centers around three core strategies to address the underlying cause of CF: repairing broken CFTR protein, restoring CFTR protein when none exists, and fixing or replacing the underlying genetic mutation to address the root cause of CF. Each approach requires a different set of scientific tools and knowledge, leading the Foundation to bring together researchers and industry leaders from a range of disciplines to advance multiple areas of research in parallel. Learn more about the Path to a Cure and related funding opportunities on cff.org.

About the Cystic Fibrosis Foundation

The Cystic Fibrosis Foundation is the world's leader in the search for a cure for cystic fibrosis. The Foundation funds more CF research than any other organization, and nearly every CF drug available today was made possible because of Foundation support. Based in Bethesda, Md., the Foundation also supports and accredits a national care center network that has been recognized by the National Institutes of Health as a model of care for a chronic disease. The CF Foundation is a donor-supported nonprofit organization. For more information, visitcff.org.

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CF Foundation Funds Three New Research Awards to Advance its Path to a Cure Initiative - Business Wire

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Want to get away from Big Tech? Heres how

Posted: at 2:43 am

My inbox is full of one question this week: How can I drop Big Tech companies? This got me thinking Is it possible to stop using the services of the Big Five altogether? Thats Amazon, Apple, Google, Facebook and Microsoft. I did the research to give you a headstart if youre looking to move away from one or all of them. If this helps you out, do me a favor and share it with your friends and family.

The recent ban of Parler from Apple and Googles app stores and the Amazon shutdown of the social media app might have you thinking about Big Techs power. Add to this news that the messaging service WhatsApp, owned by Facebook, is grabbing more of your personal data.

Tap or click to be shocked by how much of your data WhatsApp is sending to Facebook. Millions of users have now flocked to alternative messaging platforms like Signal and Telegram.

There are options to replace some of the most used apps and services. Tap or click here for Google alternatives for search, email, messaging and more.

You dont have to use an Apple or Android phone. You dont even have to use Windows on your computer. Spoiler alert: You might not like the options.

Privacy, security, the latest trends and the info you need to live your best digital life.

Smartphones are arguably the most used pieces of consumer technology today. There are more mobile devices on Earth than there are people, so that should give you an idea of how prevalent they are.

What if youre ready to ditch Apple and Google-owned Android? The Light Phoneand Blackphoneare two mobile devices focused on privacy.

The Light Phone, created by Joe Hollier and Kaiwei Tang, is a no-frills experience. Without skimping on an aesthetically pleasing design and commonly used features, the Light Phone is crafted to be used as little as possible.

RELATED:5 apps you should delete off your smartphone right now

Blackphone, on the other hand, is one of the most secure mobile phones on the market. Created by Silent Circle in 2014, the encrypted device runs on its own operating system. All communications are fully encrypted for phone and text services, and it anonymizes web searches and traffic.

You can go the Linux route, too. Fairphone, OnePlus, Gigaset and Nokia have good options available.

The fact that Google has become a verb is a testament to the reach of the worlds most used search engine. Some alternatives value your privacy and still lead you where you want to go online.

One of the most popular search engines for the security-aware crowd is DuckDuckGo. The engine steers clear of personalized results and cant use personal information like your search history or location to alter the outcomes.

LIKE WHAT YOURE READING:Get my tips delivered to your inbox.

StartPage is another search engine thats focused on privacy. The Dutch company shows Google search results but doesnt store your personal information or search data. StartPage is like a privacy filter between you and Google.

Avoiding Amazon might be more stringent than you think. While not shopping on the Amazon website is the obvious first move, plenty of other online sites use Amazon Web Services (AWS) to host their operations.

Websites like Spotify, Airbnb, Etsy and Pinterest use AWS as their cloud hosting service.

An alternative to Amazon is shopping at big box stores like Target or Walmart. With a Walmart+ membership, you get unlimited free delivery and fuel discounts for $98 a year. Tap or click here to see what Walmarts membership has to offer.

This might be the perfect time to support your local shops and grocery stores.

With so many websites and services implementing signing in through Facebook, this is a tricky connection to sever. This first major task is getting your data off Facebook. Tap or click here for how to quickly transfer your photos and videos off of Facebook.

Then, go ahead and hit that delete button. Where should you go instead?

You can start with the social media platform I created. The Komando Community is an ad-free alternative for people interested in tech and making the most of their digital lives. Tap or click here to try it free for 30 days.

Windows and Mac computers arent the only game in town. The Linux operating system has been available since 1991 and is more widely used than you would think.

RELATED:This operating system may be more powerful, secure than Windows and Apple

What sets Linux apart is its open-source software. Since its initial development and release, the Linux community has been building onto the code.

It can be daunting at first to get Linux running on your machine. But unlike Windows, almost every element is customizable through different free and open-source software packages.

The Deepin version is straightforward to install and operate. Find out how to do that here.

You can also use Ubuntu.

While it is possible to get away from Big Tech companies, or at least minimize your dependence on them, its going to be a struggle.

From social media to online shopping, the largest technology companies are firmly ingrained into the fabric of the internet. There certainly are alternatives, but what you gain in privacy, youll probably lose in functionality.

You might want to get some hair growth serum before you pull all yours out trying to get your new Big Tech-less life together.

PC slow, printer wont print or having Wi-Fi issues?Post your tech questions for concrete answers from me and other tech pros.Visit my Q&A Forum and get tech help now.

What digital lifestyle questions do you have? Call Kims national radio show and tap or click here to find it on your local radio station. You can listen to or watch The Kim Komando Showon your phone, tablet, television or computer. Or tap or click here for Kims free podcasts.

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Progressive Social Agenda — Big Tech, You’re Running Out …

Posted: at 2:43 am

Amazon CEO Jeff Bezos demonstrates the Kindle Paperwhite during Amazons Kindle Fire event in Santa Monica, Calif., September 6, 2012. (Gus Ruelas/Reuters)In adopting the progressive social agenda, Big Tech has embraced a natural antagonist.

Senator Marco Rubio is sending a warning to Amazon, and the company would be foolish to ignore it. In the pages of USA Today, Senator Rubio sided with Amazon workers attempting to unionize in Bessemer, Ala. When the conflict is between working Americans, wrote the senator from Florida, and a company whose leadership has decided to wage culture war against working-class values, the choice is easy I support the workers. It may seem a small thing for a single senator to take a moral stand (that makes no promises of action) concerning a relatively minor dispute, but Rubios op-ed is deceptively revealing. It is just the latest example of a fundamental shift in the Republican Partys attitude toward big business, away from the laissez-faire attitude conservatives have usually held and toward open hostility for woke capitals most notorious propagators. And Big Tech businesses, Amazon being one of the worst offenders as of late, have no one to blame but themselves.

While the GOP increasingly flirts with anti-corporatism, the executives at Amazon do not seem terribly disturbed. Their focus remains pandering to their natural enemies, even as they alienate their natural allies. Amazons repeated public prostrations to the Left have been less than effective at reducing political pressure on the company. March 25 saw Democrats and Republicans in the House interrogating the CEOs of Twitter, Facebook, and Alphabet. Along with other Big Tech stocks, Amazon underperformed the market broadly on the day of the hearing. While neither current Amazon CEO Jeff Bezos nor incoming CEO Andy Jassy were present at the hearing, they should still be worried: Despite all the left-wing pandering and censorship peddled by Big Tech, they have found no friends in the Democratic Party. Many of the Democrats participating in the interrogation evinced a belief that Big Tech is still, despite the last four years, insufficiently censorious. Each new demonstration of loyalty to the Left by Amazon is met with fury by conservatives, but no equivalent jubilation on the other side. Has there been an outcry of thanks from progressives for their public service in banning transphobic books?

Not in the least. Instead, Amazons accommodations have been rewarded with a growing bipartisan abhorrence for mega-cap tech companies. The Left opposes Amazon because it is a hugely successful multinational corporation led by a fantastically wealthy man, and they will continue to do so as long as they oppose corporate power and the rich in other words, as long as the Left is the Left. But now the Right is growing to oppose Amazon because it is openly hostile to the cultural values held by everyone not on the left.

When Amazon removed Ryan T. Andersons book When Harry Became Sally: Responding to the Transgender Movement from its catalogue, it alienated conservatives. When it removed a documentary about Clarence Thomas from its catalogue, it alienated conservatives. When it removed the Alliance Defending Freedom and the Family Research Council from its Smile charity program, it alienated conservatives. And yet the Democratic Party has not softened its rhetoric in the least. One need only look at Thursdays congressional hearing for proof.

Have we made the point, Bezos and Jassy? They will never accept you. The mob cannot be bought off. In the eyes of the radicals, no number of banned books or censored conservatives will atone Amazon of its original sin: being a corporation. The Left is no more fond of Amazon than it was when Ryan Anderson could still sell books on the platform. But all these tech giants have, or had, a natural defender in conservatism, a movement that has historically been oriented toward defending businesses (even the mega-caps) from the interventions of the state. Now they are losing their support, and there is little reason to believe that the next Republican president or Republican-controlled Congress will respond to years of censorship by doubling down on free markets. From Senators Marco Rubio and Josh Hawley to President Trump to Tucker Carlson, conservatives are increasingly showing an enthusiasm, if mostly in rhetoric, to forgo their partys historical inclinations and use the whips and reins of government to curtail the Lefts intrusion into the boardroom.

While GOP messaging is shifting dramatically on the question of big business, Republicans in national politics will be close to powerless for around four years at a minimum when it comes to corporate policy. Until there is a Republican president and Republican Congress, the internal debates concerning what exactly should be done about woke capital are largely theoretical, and a political solution to the problem will be impossible. But Amazons shareholders do not have to wait for a national election to act, nor do the shareholders of any other company.

The left-wing pandering of corporate America has incensed the Republican Party to the point that many of its most prominent members are advocating retribution against corporations explicitly for their political activism. That is a threat, largely self-imposed, to Amazons bottom line, which means it is a threat to shareholders, a threat which shareholders would be foolish to ignore. A natural point investors should focus on is attempts to promote viewpoint diversity, such as the shareholder resolution proposed by the National Center for Public Policy Research and subsequently shot down by Amazons Board. Insisting on a broader range of political and social ideologies at the company could make a genuine difference in the way Amazon operates.

The conservative conflict with Amazon is not, or should not be, just another partisan squabble it is a fundamental question about the role of tech giants. Are they tools for activists, utilized from time to time to make sure nobody can read books skeptical of administering hormone blockers to children? Or are they publicly traded companies, like any other, responsible first and foremost to their investors? Nobody is trying to make Amazon a conservative corporation, we would just prefer if the stewards of investor capital did not needlessly antagonize customers, investors, and potential regulators. That is not politicization of the boardroom it is the exact opposite.

Ultimately, if Big Tech does not want to be fighting a war on two fronts, they need to stop the censorship. They need to promote ideological diversity at their companies. When conservative shareholders make requests, they should not be thoughtlessly dismissed. It might upset the Diversity, Equity, and Inclusion Department, and surely some employees will complain on Slack channels, but that is better than the alternative: the consistent, careless alienation of the half of the country that would normally be on their side.

This is not going away by itself. For better or worse, there is a major shift under way in how Republicans think about the tech companies that hold their values in contempt. In addition to the prominent examples mentioned earlier, Florida governor Ron DeSantis (an early lead for the 2024 Republican nomination, according to prediction market PredictIt) introduced legislation in February that would impose fines on tech companies that deplatform candidates for public office. Amazon and other Big Tech companies are appeasing their perennial enemies, the Left, but getting nothing in return except Republican threats.

This situation is untenable. So long as Amazon behaves like a progressive nonprofit, it will be at best be held in serious suspicion by many Republicans. There is no reason to expect that to go away unless Amazon stops antagonizing those who are traditionally insistent on letting businesses operate free of government intervention. Maybe the populist shift within the conservative movement will convince Big Tech to tone down the wokeness. Maybe someone at Amazon will realize that the Left is not the only threat, and that a massive company that seems to lack any conservative perspectives makes for an excellent punching bag for the new GOP. Or maybe the executives wont listen to reason, but then at least we get to say, I told you so.

It is possible that the executives at Amazon and elsewhere are simply activists, promoting woke ideology out of genuine conviction. It is also possible that they are simply assessing risk, operating under the assumption that the Democrats are a greater threat to their independence and success than the Republicans. The former is a problem because that is not why corporations exist, and the latter is a problem because it has unambiguously failed. Whichever explanation is true does not particularly matter. The result is the same. Senator Rubio stated it outright in his op-ed: The days of conservatives being taken for granted by the business community are over.

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Progressive Social Agenda -- Big Tech, You're Running Out ...

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Is big tech now just too big to stomach? | Technology …

Posted: at 2:43 am

The coronavirus pandemic has wrought economic disruption on a global scale, but one sector has marched on throughout the chaos: big tech.

Further evidence of the industrys relentless progress has come in recent weeks with the news that Apple and Amazon both raked in sales of $100bn (72bn) over the past three months 25% more than Tesco brings in over a full year.

Amazon also revealed that its founder, Jeff Bezos, is to step down as chief executive. It was a big moment for the company founded in Seattle 26 years ago. But the shares barely stuttered, and few expect the company to, either.

The relentless rise of the big six tech firms - Facebook, Amazon, Netflix, Google owner Alphabet, Apple and Microsoft, now known as the Fangam stocks powered US markets last year.

The S&P index the barometer of corporate America ended the year up more than 18%, an extraordinary outcome given the market crash of March. But two-thirds of that gain was entirely down to the increases in value registered by the six Fangam stocks.

The gains are eye-watering. Amazons share price is up 62% over the past year, valuing the business at $1.7tn, $650m more than a year ago. Apple stock is up 70% over the same period, an increase which has taken its valuation up by more than $1tn, to $2.3tn.

Results published so far in 2021 show no sign that the gains will let up. Apple in January reported its most profitable quarter ever, and Facebook also said the pandemic had helped it grow.

Amazon recorded sales of more than $100bn for the first time in the last quarter of 2020 allowing Bezos to sound a positive note as he changed roles to focus on his ambitions in space, his Earth Fund and his ownership of the Washington Post and Alphabet posted record revenues for the second successive quarter.

The eye-catching performance of big tech has prompted increased political scrutiny and the threat of heightened regulation from Washington, especially now that the Democrats have won control of the Senate.

There is now a real possibility that President Biden will take on tech companies over issues such as privacy, liability and market dominance. And such is the collective scale of the US tech titans, it will be difficult for them to hide.

Apple became the worlds first trillion-dollar company in August 2018 (barring a few state-owned oil companies whose true valuations remain murky). Just over two years later in the midst of the pandemic in August 2020 Apple notched up the $2tn (1.5tn) milestone.

The extraordinary size of these companies can be difficult to comprehend. Alphabets $162bn of revenues outweighed the size of Hungarys economy in 2019.

Apples $67bn earnings before tax from its last financial year would pay for the UK governments combined spending on defence and transport.

Amazons army of workers worldwide now numbers 1.2 million and it is rated the third biggest employer in the world, after Walmart and the China Petroleum & Chemical Corporation.

A late (and perhaps debatable) entrant to the big tech ranks is Tesla. Investors appear to be valuing the US electric car manufacturer more like a tech platform, in the hope it will use its brand and nascent autonomous driving software to dominate transportation in the future.

That logic has propelled it into the ranks of the worlds most valuable companies (and has recently made its chief executive, Elon Musk, the worlds richest man). Its shares have rocketed from $86 at the start of 2020 to $845 now, with some investors fearing it is in the throes of an investment bubble.

One common complaint about the stock market is that it is disconnected from economic reality, with booming growth in share prices even as economies suffer historic recessions.

The flip side is the argument that these companies are more connected to our new reality than ever before: in fact, between them the big tech companies are involved in a huge proportion of human interactions with digital tech every day, from mobile phones for locked down families to the computers used in businesses all over the world.

The electric car technology pioneered by Tesla will play a key role in fighting the climate crisis and investors have belatedly got on board.

But big techs fate has become disconnected from the rest of the corporate world. As Jeremy Grantham, a high-profile investor, pointed out last month, Teslas stock market value is equal to about $1.25m for every car it sells over a year. At rival carmaker General Motors, the company is valued at $9,000 per car.

Techs rise has meant the concentration of market value in the five biggest companies has returned to levels last seen in the early 1970s.

Back then the stock market was dominated by the old industrial economy: photographic film company Eastman Kodak, ExxonMobil predecessor Standard Oil, and General Motors were in the top five, along with IBM and AT&T. Big tech has completely displaced older industries in the top five.

The rise of big tech has created the biggest personal fortunes ever seen, and a new class of hyper-rich: the centibillionaires. Almost all of that wealth comes from shares retained by founders of the business.

During the pandemic that wealth has increased at a phenomenal rate: in 2020 both Bezos and Musk gained more than $100bn apiece or about $3,000 per second.

But there are other beneficiaries. Among the biggest shareholders in all of them are Wall Street and City investment companies such as BlackRock, Vanguard and Legal & General. While those asset managers earn juicy fees by charging clients such as pension funds a percentage of stock market gains from the growth of big tech, their growth also benefits the ultimate owners including the pension funds providing for hundreds of millions of people saving for retirement.

UK fund manager Baillie Giffords investments in Tesla have made an extraordinary $29bn (21bn) for investors including pension funds, foundations and charities, according to figures released to the Guardian. Scottish Mortgage Investment Trust, which is managed by Baillie Gifford, began buying Tesla heavily in 2013 when the shares were changing hands at about $6 each, compared with todays $840. That soaring share price led Scottish Mortgage to be admitted into the FTSE 100 index of the UKs biggest listed companies in 2017 and last year the price rise made Scottish Mortgage the best-performing company in the FTSE 100.

With size comes power. A simple change in an algorithm can wipe out smaller companies reliant on tech companies platforms or even nascent industries. Changes to Facebooks algorithm in 2018 hit some viral publishers revenues hard, while the complexities of negotiating Amazons search rankings have spawned an advisory industry.

And the companies have also sought increasingly to influence politics. Google overtook Goldman Sachs as the biggest spender on political donations for the first time in 2014. The six tech companies total spend on lobbying in the US had risen to $64m in 2019, according to the US Center for Responsive Politics. While that amount is tiny compared with the companies profits, its rapid rise represents big techs increasing attempts to influence policy directly.

Big techs increasing size gives it another big advantage: the bigger it becomes, the harder it is to challenge.

This has always been a problem with dominant companies, who are able to use their scale to win better deals and lower prices. But with the tech platforms such as social networks or Amazons retail network, the more users they have, the faster their value grows. It is what economists call the network effect.

Some of the big tech companies have been able to avoid any major competition enquiries in part because they offer consumers cheaper services than ever before. However, there is increasing scrutiny of monopolistic practices.

One area of focus has been their willingness to pay what seemed like very high prices for fast-growing competitors.

Emails unearthed by US Congress showed that Mark Zuckerberg said Facebook should buy Instagram in part to neutralise its threat. Facebook has contravening previous pledges started to slowly combine Instagrams messaging technology with its other social network, Whatsapp.

Google faces intense antitrust scrutiny in the US over its dominance of internet search, which the EU in 2017 found it had abused by boosting results for its own services.

Apple is facing a growing backlash by companies trying to sell services to iPhone users. Epic Games, the maker of the wildly popular Fortnite franchise, and music streaming platform Spotify have both launched legal complaints against Apples insistence that it takes a 30% cut of all sales made through the app store including music streaming subscriptions that Spotify and many other third-party app developers have long complained is an unfair tax.

One controversy is common to all of the US tech companies (although by no means confined to them): tax avoidance techniques that critics see as aggressive and unfair to smaller competitors.

All of the big tech companies use subsidiaries in low-tax countries such as Luxembourg, Bermuda and Ireland to sell services to end markets such as the UK. Fair Tax Mark, a non-governmental organisation, last year singled out Amazon in particular for its opaque tax structures and low amounts of tax paid relative to profits.

Globally, Fair Tax Mark calculated, the six big tech companies had paid $100bn less cash in taxes over a decade than they had provided for in their accounts, primarily by shifting profits to tax havens and using creative accounting techniques that are legal, but are usually unavailable to smaller companies.

The companies paid $155bn less than might be expected under headline tax rates money that could have been used to fund public services and infrastructure around the world.

Complex legal structures make it impossible to work out precisely how much profit the big tech companies shift out of individual countries, but Tax Watch UK, a campaign group, estimated that Google, Facebook, Apple and Microsoft, as well as network tech company Cisco, avoided 5bn in UK corporation tax between 2012 and 2017.

None of the companies have confirmed such data, although all have said their tax structures follow the law.

World leaders are acutely aware of tax issues in particular, and there has been some progress on moving towards a global tax regime to reduce profit shifting from country to country. The US government has up until now looked askance at efforts coordinated by the Organisation for Economic Cooperation and Development to allow other countries to tax American tech champions more. However, a Biden administration may make a limited deal more likely.

Individual countries have tried to target big tech, including the UK with its digital services tax. But Amazons revelation that it will not itself pay the levy but will pass it on to other sellers which use its platform shows how difficult it is for one country to strike out on its own.

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The most likely challenges to the big tech companies are likely to come from policymakers in their two biggest markets: the US and the EU.

The EU has won some notable victories against the tech companies, but has also some painful defeats such as a court ruling last year that Apple did not have to pay a 13bn (11.4bn) Irish tax bill. More onerous regulations in the second biggest market could be costly for tech companies.

In the US, businesses have been forcibly broken up in the past. Most famously, in 1911, the Sherman Act of 1890 was used to force Standard Oil to split into 34 separate companies. It was used again to force the breakup of the AT&T telephone company in 1984 and against Microsoft in 1998, though an order to split that company into two was later overturned on appeal.

More recently in the US Congress a committee report found big tech has too much power, and Google and Facebook face significant if limited antitrust actions by US regulators and prosecutors. In October last year, the US Department of Justice filed an antitrust case against Google and said it was again enforcing the Sherman Act to restore the role of competition.

However, these complex cases could last years, and it is likely that the authorities would settle for remedies short of a complete breakup.

There is growing consensus on both sides of the bitter political divide that some of the big tech companies need more oversight, although finding consensus on solutions will be much more difficult.

Kamala Harris, then a US senator, said in 2019 that there needed to be more regulation. Whether that attitude is picked up by Joe Bidens White House now Harris is the vice-president is the biggest question facing big tech over the next four years.

Graphics by Glenn Swann, Paul Scruton, Finbarr Sheehy and Cath Levett

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France’s plan to rein in Big Tech (and Ireland and Luxembourg) – POLITICO.eu

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PARIS The French government wants to beef up EU rules for Big Tech and that means wresting power away from Dublin and Luxembourg, the two capitals that have so far been responsible for enforcing them.

According to briefings with French officials and documents seen by POLITICO, Paris plans to rework the EU's content moderation bill so that it doesn't have to rely on other countries' regulators to police and if required, punish the biggest platforms.

Paris does not want to be "completely dependent on the responsiveness, the willingness to move quickly of the country-of-origin's regulator," an official from the economy ministry told reporters Wednesday.

Paris's proposals come just as the EU's economy ministers pore over the EU's content moderation rules and its proposal to curb the largest tech companies' market power known respectively as the Digital Services Act and the Digital Markets Act.

France hopes EU countries will assent to its proposals when it takes over the Council of the EU's rotating presidency in January. The government aims for an agreement on the Digital Markets Act under its presidency, but French Secretary of State for Digital Cdric O acknowledged earlier this week that the Digital Services Act, which is more contentious, might take some more time. On Thursday, O said that France still aimed to take the DSA to the finish line.

"Not everything is a red line [for France], but these proposals are contributions to the debate which we hope can create common ground ahead of the French presidency" of the EU, the economy ministry official said.

In the Digital Services Act, the European Commission kept an EU provision known as the "country-of-origin principle," which states that companies are regulated by the authority of the country they're legally based in. For almost all Silicon Valley giants, that means either Luxembourg or Ireland.

Paris said it does not want to overhaul the principle, but to buttress local regulators alongside the lead authorities, according to amendments seen by POLITICO. That means allowing local regulators to impose interim measures in case of emergency, for example.

French officials, including O, have regularly indicated that the Irish authorities are not doing enough to crack down on U.S. tech giants for potential violations for the EU's data protection rules. They want to ensure the same doesn't happen under the DSA.

"We have learned from the experience of the previous texts currently in force, and we need to invent somewhat innovative mechanisms," an official from O's cabinet told reporters Wednesday, in an apparent reference to the EU's data protection rules, which are governed by the so-called one-stop shop principle that has faced criticism from regulators and EU lawmakers as being inefficient.

On Thursday, O doubled down. "France supports the country-of-origin principle. But it seems to us that the General Data Protection Regulation experience, albeit a great political success, [shows there is a need for] improvements when it comes to cooperation between EU countries," he told reporters.

"We see with GDPR that appeal mechanisms ... and case resolutions are insufficient," he added.

The French government wants the lead regulators to be required to share data with other authorities, with the possibility of reallocating cases "by mutual agreement."

In practice, the reallocation plan would mean national authorities French ones, for example would ask their Irish counterparts whether they plan to investigate any suspected infringement in France by a big platform like Google, Facebook or Twitter (all of which are legally established in Ireland) and would launch an investigation themselves if Ireland doesn't reply within three weeks.

If the Irish authorities do decide to open a probe, they would have to grant access to all the information from the proceedings and involve the French authorities in the final decision. France could also raise a "reasoned objection" if it doesn't like Ireland's initial decision.

The network of EU country representatives the so-called Digital Services Coordinators should settle disagreements between national authorities if one believes action wasn't taken or the outcome of an investigation wasn't satisfactory.

Further, where "serious harm is likely to occur," France argues that local authorities should be able to impose interim measures on online platforms as well as to request an "emergency binding decision" from Digital Services Coordinators, to be adopted within two weeks.

Despite the proposed changes, O said: "France does not want content regulation based on the country-of-destination, but we want to see some form of efficiency."

In addition to empowering its own regulator to police Big Tech, France also wants to impose stricter rules than what the Commission has already proposed, especially those concerning online marketplaces like Amazon and eBay.

Currently, the Digital Services Act requires online marketplaces to collect information about the seller, also known as Know-Your-Business-Customer obligations.

But France is worried the current rules might not go far enough. Other EU countries and the European Parliament agree with Paris, said O, who met with the Parliament's lead negotiator Christel Schaldemose Thursday.

The French government pitches four obligations for online marketplaces, according to a document seen by POLITICO: Ensure consumers have access to the necessary information related to products before the products are put on sale; prevent dangerous or non-compliant goods from being put on sale; ramp up the fight against counterfeit products; and ensure cooperation between national authorities when dangerous products have already been sold.

Online marketplaces would be required to prevent products without the necessary information from being posted online, and to check goods against publicly available databases before they're put on sale to ensure they haven't been flagged as dangerous. They would also be required to warn consumers and arrange recalls if the seller of a dangerous product is unresponsive.

The rules would not apply to micro and small enterprises, and Paris said is willing to be somehow flexible about which online marketplaces the rules would apply to.

"We need to keep in mind that, on product safety issues, we can't afford to have too broad exemptions," said the official from O's cabinet, "we'll have to see whether adjustments on a case-by-case basis are possible."

Alongside its work on content moderation, the French government has also lined up a host of amendments to a separate bill that regulates digital competition, known as the Digital Markets Act. The bill's purpose is to rein the market power of the most powerful companies, which the bill will designate as gatekeepers, and applying specific rules to them to ensure fair competition.

The French plan, seen by POLITICO, including widening the bill's scope to include web browsers (Google's Chrome and Apple's Safari, for example) and voice assistants (Apple's Siri and Amazon's Alexa). It also wants to ensure that the practice of self-preferencing, where a company favors its own product over its competitors, also applies to app stores.

The plan is likely to get backing from Berlin, which has raised similar concerns about web browsers and voice assistants.

In a paper signed with Germany and the Netherlands published Thursday, France called on the Digital Markets Act to be strengthened to require regulators to assess all mergers and acquisitions by gatekeepers. The three countries also want the bill to determine whether a company qualifies as a gatekeeper if it offers "an ecosystem of services."

Paris wants businesses and users to be able to alert the Commission of potential infringements to help with the bill's enforcement. To that end, it proposed a process dubbed a "reporting mechanism" that would facilitate speedy communication between them.

Unlike its efforts with the Digital Services Act, France said it is happy with leaving enforcement of digital competition to someone else, as long as EU countries can request market investigations. The Commission is largely responsible for ensuring fair competition in the bloc.

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Paris and Berlin urge EU to crack down on Big Tech – POLITICO.eu

Posted: at 2:43 am

A coalition of big EU states is cranking up the pressure on Brussels to do more than just spell out new rules for the tech sector and start cracking down on bad behavior.

In a letter published on Thursday, Germany, France and the Netherlands took the rare step of explaining what they felt was wrong with the EUs proposals regulating digital competition, the Digital Markets Act (DMA).

The DMA aims to rein in the market power of juggernauts like Google, Amazon and Facebook. But the capitals said the proposal as currently written lacks ambition when it comes to so-called killer acquisitions when big companies gobble up promising startups to neutralize potential rivals.

We have to strengthen and speed up merger control in particular towards certain gatekeeper platforms, stressed the letter, which overshadowed the Competitiveness Council, a gathering of EU ministers in Brussels on Thursday to discuss the DMA and another set of rules on content moderation.

The letter came as officials in Germany, France, Italy and other countries are increasingly taking tech regulation into their own hands, and pushing for new powers to crack down on big players.

Taking aim on Tuesday at the EUs new proposed rules for online content, called the Digital Services Act (DSA) Berlin called for a much tougher approach including an all-out ban on targeted advertising to minors, according to a Council document seen by POLITICO. At the EU ministers meeting Spanish and Danish ministers also pressed for more action.

Frustrated by what they perceive as slow-moving or ineffective enforcement of rules, the capitals that signed the letter calling themselves the Friends of an Effective DMA are also seeking to bring more powers into their own hands.

The importance of the digital markets for our economies is too high to rely on one single pillar of enforcement only, blasted the Friends of an Effective DMA in the letter. Therefore, a larger role should be played by national authorities in supporting the Commission.

Several EU countries have echoed those concerns with regard to the DSA, saying regulators could become overwhelmed by monitoring online services. They were likely referring to watchdogs in Ireland and Luxembourg, which oversee many Big Tech companies as a result of the blocs enforcement system.

Asked about the apparent split between Brussels and the capitals, the EUs top digital regulator Margrethe Vestager pushed back on criticism.

The legal basis wasnt really supportive for demands for tighter merger control, she told the Competitiveness Council on Thursday.

We already have the first of these acquisitions on our working table and that is due to excellent cooperation with national competition authorities, she added.

This refers to the probes the EU Commission has opened against the acquisition of health and education chatbot company Kustomer by Facebook, and the acquisition of cancer test-startup Grail by biotech company Illumina.

We cannot wait for the proposal to watch for this kind of acquisitions, Vestager said, in a subtle reminder to the ministers that the DMA and the DSA are on a tight schedule.

The aim is to conclude both of them under French presidency, in the first half of next year. An all-too-heavy attack on the legal basis and enforcement mechanisms could potentially threaten that timeline.

Leonie Cater, Laura Kayali and Clothilde Goujard contributed reporting.

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The Political Fix: Does anyone trust Modis government to genuinely place checks on Big Tech? – Scroll.in

Posted: at 2:43 am

Welcome to The Political Fix by Rohan Venkataramakrishnan, a newsletter on Indian politics and policy. To get it in your inbox every week, sign up here.

If you missed our Q&A last week, we spoke to Sumitra Badrinathan about the mechanics of misinformation in India and what it will take to tackle the problem.

Indias second Covid-19 wave is a huge story. Help our small team cover the big issues. Contribute to the Scroll Reporting Fund.

The ongoing battle between Big Government and Big Tech in India calls to mind the tagline to a 15-year-old Hollywood film that pitted two insatiable creatures against one another: Whoever wins, we lose.

Over the last week, two of the globes social media behemoths Facebook, though its subsidiary WhatsApp, and Twitter decided to take issue with the Indian governments efforts to exert more control over them.

The two cases are slightly different, so lets tackle each one by one:

Summarising Government of India vs Twitter, at least in its most recent iteration, is fairly simple:

The Indian government threw a tantrum after Twitter labeled propaganda from the ruling Bharatiya Janata Party as manipulated media. It even sent an anti-terrorism unit of the police to Twitters offices, and then complained about India being defamed when the social media company referred to these intimidation tactics.

The full story is a bit more convoluted, as I explained here.

The BJP, struggling to contain the political fallout of its Covid-19 mismanagement over the last two months, put out what it said were embarassing strategy documents of the Congress that revealed the depths the Opposition party would go to in an effort to criticise Prime Minister Narendra Modi.

Fact-checkers concluded that the more controversial bits of this toolkit were apparently forged, featured instructions with a date well after they would have been useful without actually having been used by Congress handles, and bore a striking resemblance to right-wing talking points on a Twitter thread.

Twitter promptly declared the material manipulated media, without offering any further explanation.

The BJP, however, could not stand to see its propaganda given this critical label. The government complained to Twitter, asking it to remove the tag though it has no powers to demand this.

It made the deeply questionable argument that Twitter could not arrive at a conclusion on the content while it was still under investigation. For perspective, imagine if social media networks had to wait for an executive or judicial order before taking down suspected fake news messages or videos.

And it assigned the forgery case, filed by Congress leaders, to the Delhi Police Special Cell which usually investigates terrorism and has a chequered, political past. Instead of looking into the forgery, the police seemed more interested in going after Twitter, which may be why the Congress leaders now want the case to be investigated by Chhattisgarh Police. The important context here is that Twitter caved in to demands to censor social media handles earlier this year during the farmer protests, when the Indian government threatened its local staff with jail time.

This forgery case has now led the government of India to declare that Twitter is attempting to declare terms to the worlds largest democracy.

WhatsApps lawsuit against the government is a somewhat larger version of the same battle the BJP-run governments attempt to exert control on Bigh Tech though with more systemic implications.

In short: Controversial new executive rules from the Indian government require apps like WhatsApp to break privacy rules, and allow authorities to identify originators of messages whenever they want. WhatsApp has now filed a lawsuit in the Delhi High Court arguing that this is a violation of the fundamental right to privacy and the fundamental right to speech.

Like Twitter, this isnt the first run-in between WhatsApp and Modis government. Just last week, the government threatened to take legal action against the Facebook-owned messaging service if it did not roll back its controversial new privacy policy.

On that issue, the Indian state is portraying itself as the entity defending the privacy of Indian citizens. On end-to-end encryption, however, WhatsApp is the one citing privacy and the state is claiming that its demands are reasonable.

WhatsApps lawsuit has global implications.

If the service is forced to break end-to-end encryption in India, it might face similar pressure from governments elsewhere, starting in Brazil where authorities have been pushing for a very similar outcome. The result also will not be limited to WhatsApp, since the rules apply to all messaging services, including others like Signal and Telegram, believed by some to be safer from surveillance.

Modis government has over the last few years sought to weaponise the conversation around the potentially pernicious influence of Big Tech on democratic societies all over the world.

Civil society all over the world, including many in India, have pointed out the dangers of letting these companies amass unchecked power over our communication and commerce, with little regard for privacy or individual rights. This is, after all, the country that saw a large-scale mobilisation against Facebooks attempt to break net neutrality. Those criticisms are exactly why Facebook set up an Oversight Board, to help govern its platform.

Piggybacking on the civil society criticism of Big Tech, the BJP has added the language of nationalism to these debates, referring to the social networks as digital colonisers and contemporary versions of the East India Company. In this worldview, any pushback from Facebook or Twitter amounts to challenging Indian sovereignty, proof of how little the companies care about Indian citizens.

But instead of putting the Indian citizen at the centre of its approach towards tech regulation, the BJP wants to hand more power to the authorities, with little in the way of checks and balances. Its aim is to take power away from big tech and hand it to the government, not the citizen.

Some have argued that this will still be useful, since the government may be more answerable to its people. But, does anyone trust this government infamous for its treatment of criticism as sedition, its willingness to censor inconvenient information, its readiness to switch off the internet at the drop of a hat to judiciously build a regulatory framework for technology that will benefit Indians?

Consider:

What happens if it is allowed to exercise more power over social media?

We already have a sense, thanks to Facebook. As the Wall Street Journal and the Guardian have reported, Facebook overruled its own guidelines on hate speech and fame accounts including not taking down content calling for Muslims to be shot simply because that material was uploaded by the BJP. Remember, Home Minister Amit Shah once argued that his party was capable of delivering any message, real or fake, to the public by making it go viral.

Meanwhile, social media networks routinely silence accounts critical of the BJP on the governments instructions, with little transparency or opportunities to challenge these actions.

It is clear that the power held by Big Tech at the moment is tremendous and the frameworks to hold them accountable cannot come from Western societies and contexts alone. Some of Indias new rules do take some steps forward on this front, as Apar Gupta writes. But the vast majority of the moves from the BJP-run government seem like a naked power grab, in the hopes of neutralising dissent and exercising even more control over the populace.

If the government gets its way then, we could have the worst possible outcome: No real checks on the data-hungry ways of Big Tech, even as Big Government gets to do as it wishes. Whoever wins...

Thanks for reading the Political Fix. Send feedback to rohan@scroll.in.

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Amazon, Google, and Big Tech Want to Eat Health Care Next – The New Republic

Posted: at 2:43 am

This bloodless technocratic language should sound familiar: Its the same attitude exhibited by the V.C. at that tech conference a few years back, and it is totally removed from peoples fundamental material needs. Theres talk of ease of access and furnishing better care but little discussion of what really matters: universal care thats free at point of service. Nor do Silicon Valleys would-be health care entrepreneurs evince much concern for concepts like health care justice, reproductive rights, or repairing systemic inequities. New algorithms may hold out promise for processing masses of medical images, but even these supposed breakthroughs come with deficiencies, often owing to biased training data. One New England Journal of Medicine study found that algorithms used in a variety of medical contexts can reinforce racial biases, compromising care. In this arena, disrupting health care doesnt mean repairing a broken system; it means leveraging that systems vulnerabilities to innovate new delivery systems and new forms of profit.

That V.C.s dream of Americans spending more of their income on health care may have been ghastly in its insensitivity to peoples real concerns, but it remains a sad market reality. U.S. health care spending grows consistently, reaching $11,582 per person in 2019. Insurance premiumsand insurance company profitshave risen far faster than workers wages. One study found that Americans now spend double on health care what they did in the mid-1980s. Tales of Americans refusing health care for fear of billspassing on an ambulance ride or delaying treatment for an acute conditionare legion. Medical bills remain one of the leading contributors of consumer bankruptcya novelty for large swathes of the world where no one must pay for medical care, much less risk bankruptcy.

The solution, as its long been, is clear: a universal health care system that provides free care. The principle is as simple as the fire department or the local libraryshared services that everyone pays into and are free when they need thembut its one that would likely be lost on most politicians today. (If public libraries were proposed now for the first time, how many Democrats would join Republicans in voting against them?)

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DeSantis’s ‘Big Tech Bill’ Is Actually a Step Closer to the World Orwell Feared | Jon Hersey – Foundation for Economic Education

Posted: at 2:43 am

On Monday, Florida Gov. Ron DeSantis signed a Big Tech Bill that he says is designed to combat Orwellian censorship by companies such as Facebook, Twitter, and Google. The law requires companies to publicly disclose their moderation policies (something most, if not all, already do) and to stick to those policies consistently. If they dontor if users think they dontthe companies can be sued for up to $100,000 per offense.

For the past several years, everyone from Sacha Baron Cohen to Elizabeth Warren to Donald Trump has advocated for strict new regulations on tech companies, with conservatives in particular charging these companies with censorship. Is DeSantiss new law the big win for free speech that he says it is, or is it the very sort of rights violation the governor claims to be fighting?

Its no secret that tech CEOs support the political left; Mark Zuckerberg called Silicon Valley an extremely left-leaning place. Senators Josh Hawley and Ted Cruzalong with such commentators as Dennis Prager, Ben Shapiro, Dave Rubin, Eric Weinstein, and Sam Harrisclaim that the moderation practices of social-media companies demonstrate an unmistakable anti-conservative bias. And many, including DeSantis, say this bias is a form of censorship.

If Big Tech censors enforce rules inconsistently, to discriminate in favor of the dominant Silicon Valley ideology, says DeSantis, they will now be held accountable. He tweeted: Floridas Big Tech Bill gives every Floridian the power to fight back against deplatforming and allows any person to sue Big Tech companies for up to $100,000 in damages. Today, we level the playing field between celebrity and citizen on social media.

Theres no denying that tech companies have tremendous power over what users see on their platforms. And given that, as the Pew Research Center reports, some 72 percent of Americans use some form of social media, platforms certainly have a hand in shaping debates. So its understandably maddening when these companies use their platforms to help one group push an agenda that many others consider destructive, promoting the content of some while shadow-banning others.

Thus, conservatives, seemingly the special target of the Silicon Valley elites, as DeSantis calls them, have long been attempting to fight back against this so-called censorship. In May 2019, President Trump tweeted: I am continuing to monitor the censorship of AMERICAN CITIZENS on social media platforms. This is the United States of America and we have whats known as FREEDOM OF SPEECH! We are monitoring and watching, closely!! Six weeks later, Senator Hawley introduced a bill to amend the Communications Decency Act, revoking the legal protection that keeps social media companies from being sued for things that users post. Hawley failed to change the federal law, but DeSantis has succeeded at the state level with a more targeted set of regulations.

Tech companies have yet to respond, so we dont know whether they will play ball, oppose the law in court, or exit markets as they have in some countries, leaving usersincluding many businesses that rely on social media for advertisingwithout service. What is clear though, is that the law inserts government into the process of social-media moderation. Elected officialsbeholden to their parties and constituents, always vying for re-electionwill now have a hand in refereeing what is politically neutral and what is not. Is this a rational means of fighting censorship, or is the law itself an indirect means of instituting censorship? Further, are social media companies actually censoring people by moderating the use of company property as they see fit?

Suppose you use your time and resources to build an actual wall and then invite your neighbors to graffiti it as they wish. Some are talented like Banksy, creating interesting works of art, whereas others defile it with the equivalent of fifth-grade toilet humor. Most are somewhere in between. Its your property, and you decide to paint over all of the crude stuff, plus some things you just dont like. Could this properly be called censorship? Does it violate anyones right to free speech?

Definitely not. The reason the Founding Fathers wrote into the very first amendment that Congress shall make no law . . . abridging the freedom of speech, or of the press is because they understood that government has a monopoly on the legal use of force. If you dont do what the government tells you, it can take your property or put you in jail. Censorship means restrictions on speech backed by forcethat is, by government.

Private companies, on the other hand, may use their property however they see fit, but they cannot force you to do anything. As Ive written elsewhere,

Its not censorship if a Christian publisher rejects an atheists book, or if a left-leaning newspaper doesnt hire (or fires) a freedom-loving columnist, or if a Romantic art gallery refuses to display a banana duct-taped to a wall, or if a social-media platform bans Alex Jones. The right to speak ones mind is not a right to a book contract, a newspaper column, a gallery exhibit, a social-media platform, or to any product of another persons effort. A persons right to speak his mind is not a right to another persons property or support. There can be no right that violates another persons rights.

Love or hate their policies or politics, every successful tech entrepreneur started with a vision for providing value to users, then invested massive amounts of time and effort bringing that vision to life. They poured their life and property into their products and services, which they rightfully own and may use or moderate as they see fit.

If people dislike a companys policies, they have plenty of options. They are free to stop dealing with that company, to convince others to boycott it with them, to try getting a job at that company where they can advocate change from within, or to start a competing company. What they cannot rightfully do is use government power to force others to supply them with a platform moderated according to their preferences.

DeSantis is not leveling the playing field as he says, but rather trying to use government power to constrain how companies use their propertyand, in so doing, hes carving a role for government in moderating speech. If we want a free and fair internet, we must respect the rights of tech companies, vote with our screen timeand reject DeSantiss move toward a truly Orwellian world.

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DeSantis's 'Big Tech Bill' Is Actually a Step Closer to the World Orwell Feared | Jon Hersey - Foundation for Economic Education

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Americans trust banks over fintechs and Big Tech with personal data – Finextra

Posted: at 2:42 am

Americans trust traditional banks more than government agencies or fintechs - and far more than Big Tech - to safeguard their personal data, according to a BIS survey.

The survey of around 1300 US household heads asked respondents to give sectors a score of between one (no trust at all) and seven (complete trust) when it comes to safeguarding data such as bank transaction history, geolocation and social media data.

For Big Tech - Google, Amazon, Facebook, Apple - the median respondent assigns a value of two, with three quarters of all respondents choosing a value in the range of one and three.

Government agencies and fintechs like PayPal, score a median level of four, although there is a greater dispersion than for big tech.

Banks, meanwhile, score a median value of five. Over three quarters of respondents give traditional FIs at least a four, with over 25% giving them six or higher.

There are differences across demographic groups: respondents from racial minorities have less trust in financial institutions, while younger people trust fintechs relatively more. Female, minority and younger respondents are more concerned about implications of data-sharing for their personal safety.

A quarter of respondents say Covid-19 made them less willing to share data. In this group, nearly half became less willing to share with big techs, with concerns centred on identity theft and abuse of data.

BIS says that the digital shift during the pandemic might "impose disproportionate harms on some groups, which may also lead to differences in digital adoption".

Concludes the paper: "Understanding and addressing these concerns through sensible regulation is essential if digital technologies are to be used in a safe and inclusive way for all in society."

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