Daily Archives: April 27, 2021

Elon Musk and NASA May Finally Have the Same Goal: Putting Humans on Mars – News18

Posted: April 27, 2021 at 6:18 am

Elon Musk wants humans to colonize the moon. He may not be the only one anymore. The Tesla CEO and SpaceX boss has mentioned putting humans on the red planet multiple times, and even put a timeline to it: 2026. While NASA has had a later date, he may finally have someone backing him up. NASA recently announced its partnership with SpaceX to return to the moon by 2024. Following this announcement, Scott Hubbard, who formerly led the agencys Mars program, was hopeful there would be some news about future crewed trips to the Red Planet. And it happened - NASAs press release did mention Mars.

Elon Musk has often said he wanted to get people to Mars as soon as possible. He expected to have 1 million people on Mars by 2050, he said in 2020.

Musk in February 2021 for the first time ever mentioned a timeline to get humans on the red planet. Five and a half years," Musk said.

While thats not a hard deadline. Musk listed a number of caveats theres a raft of technological advances that must be made in the intervening year. The important thing is that we establish Mars as a self-sustaining civilization," he said.

The strange thing is the deadline may be a little ambitious, as even USAs leading space agency, NASA, had a much more different date, one which is seven years after Musks time but the first humans arent due to arrive on a NASA funded rocket until at least 2033. That will be part of the Artemis - to the Moon and Mars - mission that will first see a sustainable presence established on the lunar surface.

Musk also answered other questions about Mars. Over time you can make Mars Earth like by terraforming the planet by warming it up, said Musk.

When asked if he would allow his children to go to Mars on a future rocket trip he said if were talking about the third or fourth set of landings on Mars Id be ok with that, adding that so far none of them are jumping to go to Mars.

But humans surviving the journey to Mars may be a little ambitious - A study found that energy-producing structures in cells might be the reason astronauts face health risk while in space.

Over the years astronauts have reported loss of bone and muscle, while some have developed immune disorders or heart and liver issues - all which have been may be triggered by the same thing.

Frank Borman was probably the first person to barf in space. Borman was part of NASAs Apollo 8 mission, which lifted off a launch pad in Florida on December 21, 1968. Over the next six days, the mission made history as it circled the moon and returned home. But Borman, who led the mission, became queasy near the beginning. I threw up a couple of times, he recalled in an interview in 1999.

Space sickness isnt the only side effect to accompany the thrill of leaving Earth. A 2015 NASA report identified 30 factors that could make astronauts sick and unable to do their jobs. And there may be more, it said. Until people visit Mars it will be difficult to fully predict what could go wrong.

Some of the known risks arent simple or minor: Along with space sickness, there is radiation high-energy subatomic particles that will pass through an astronauts skin, damaging cells inside and out. Space travelers bones and muscles also can weaken as those body parts no longer have to constantly work against gravity. Blood and other fluids from the lower parts of the body can accumulate in upper body parts, including around the brain. One side effect: Astronauts may suffer hearing loss.

The new study by systems biologist, Afshin Beheshti, which was conducted by Dataf from NASAs GeneLab, looked at proteins and RNAs in each sample. The team also examined blood and urine from 59 astronauts. Spaceflight seemed to have caused many biochemical changes in them. One symptom: Space travelers had more chemicals known to trigger inflammation. The researchers also found signs of oxidative stress, a type of cell damage. That damage can be due to poorly functioning mitochondria.

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New Book: Social Darwinism Among the Biologists – Discovery Institute

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Photo: Ernst Haeckel, via Wikimedia Commons.

Editors note: For Parts 1 and 2 of Professor Weikarts review ofSocial Darwinism, seehere and here respectively.

One of the key problems with Jeffrey OConnell and Michael Ruses new book onSocial Darwinismis what it omits: substantive discussion of social Darwinism among Darwinian biologists, especially the kind of social Darwinism that justified militarism, racism, and even racial extermination. To be sure, they do discuss Darwin himself they couldnt really get around that. However, from Darwins time until Julian Huxley in the mid 20th century, the only biologists mentioned are those who opposed social Darwinism e.g., Thomas Henry Huxley. (I should note that despite his rejection of evolutionary ethics, Huxley was not entirely free of social Darwinism see my essay on this here.)

The figures during this period that they do discuss are industrialists, military men, and politicians. Why is this? It is not for lack of examples, because many Darwinian biologists in the late 19th and early 20th century were social Darwinists who promoted laissez-faire capitalism and/or militarism and/or racism and/or racial extermination.

The most conspicuous omission is Ernst Haeckel, the leading Darwinian biologist in Germany. Actually, the authors do discuss Haeckel briefly, but their comments misleadingly imply that he was not a social Darwinist. For instance, they mention that he opposed World War I. However, they conveniently dont explain that the reason he opposed European countries fighting each other was because he thought European wars killed the wrong people the best and brightest, the so-called fittest. Thus, he thought Europeans should focus their military activities on exterminating inferior races in colonial wars. The authors also forget to mention that during World War I Haeckel changed his mind and wrote an entire book justifying the German war effort and promoting German expansionism. In that work he interpreted the First World War as an expression of the Darwinian struggle for existence.

Haeckel was by no means an outlier. As Ive shown inFrom Darwin to Hitler, many German biologists embraced social Darwinist militarism and racial extermination. Many American biologists also promoted social Darwinist positions. Henry Fairfield Osborn, professor of zoology at Columbia University in the early 20th century, wrote a foreword to Madison Grants racist screed,The Passing of the Great Race. Charles Davenport, a Harvard professor who founded the Eugenics Record Office, promoted immigration restrictions against the allegedly inferior stock that was coming to the United States in the early 20th century. Social Darwinist racism was so mainstream in early 20th-century America that it appeared in standard biology textbooks.

Despite ignoring all these scientists who promoted social Darwinist positions, the authors do later discuss Julian Huxley, a politically progressive biologist who promoted evolutionary ethics, and E. O. Wilson, the founder of sociobiology. However, they dont really make clear if they think Huxley was a social Darwinist or not. They also dont explicitly say that Wilson is a social Darwinist, but they seem to imply it by tagging him as a Spencerian (see my previous post on Darwin and Spencer).

Why is this omission so problematic? After all, this is a short book and they cannot discuss everything. The reason is because it implies that social Darwinism was a position taken by non-scientists who just didnt understand the science when they applied Darwinism to political and social thought. It neglects an important facet of the story: Many Darwinian biologists and anthropologists in the late 19th and early 20th centuries argued that biological inequality, racism, and militarism were based on sound scientific (i.e., Darwinian) principles. Haeckel, for instance, scorned socialists for their un-Darwinian egalitarianism. You will not discover it in this book, but in its heyday social Darwinist racism and militarism were considered scientific.

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New Book: Social Darwinism and The Hitler Problem – Discovery Institute

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Editors note: For Part 1 of Professor Weikarts review of Social Darwinism, see here.

In Cambridge University Presss new bookSocial Darwinism,Jeffrey OConnell and Michael Ruse tackle an issue that I have written about extensively: the connections between Darwinism and Nazi ideology. Unfortunately, however, as far as I can tell, they ignore almost everything I have written (I have to say almost because they do quote from a blog post I wrote). To be sure, they do cite my book,From Darwin to Hitler: Evolutionary Ethics, Eugenics, and Racism in Germany, though I cannot tell if they read a line of it, because they never discuss any specific material from the book. Worse yet, they do not even cite my later books,Hitlers Ethic: The Nazi Pursuit of Evolutionary Progress(2009) orHitlers Religion: The Twisted Ideas that Drove the Third Reich(2016), even though these are the most thorough and important scholarly books that deal with the topic of Hitlers social Darwinism.

In their chapter on The Hitler Problem they make the completely untenable assertion that Hitler did not believe in evolution at all. As is obvious from their citations, the way they came to this conclusion was by reading Robert Richardss works, especiallyWas Hitler a Darwinian?(Richards answers his question with a resounding, No!).

My book,Hitlers Ethic, contains an avalanche of evidence that Hitler believed in evolution, including human evolution. My later book,Hitlers Religion, contains a chapter, Was Hitler a Creationist? that directly refutes Richardss false arguments. Here I can only provide a few tidbits, but if anyone wants more evidence, including explicit refutations of Richardss claims, please consult these works.

Let me give some examples of Hitlers belief in evolution and social Darwinism from a variety of sources: HitlersMein Kampfand hisSecond Book, his speeches, his monologues, and testimony from his associates.

InMein Kampfand in hisSecond Book, Hitler not only uses Darwinian terms constantly, such as evolution, struggle for existence, and struggle for life, but several times he explicitly describes the struggle for existence as a natural law that humans should be careful not to contravene. In one passage he mentioned that the struggle in nature vanquishes the weak and sickly, and then stated,

Always struggle is a means to improve the health and stamina of the species, and thus a cause of its evolution. By any other process all development and evolution would cease, and the very reverse would take place.

In HitlersSecond Book, social Darwinism is even more obvious, as Hitler opens the book with a chapter on The Struggle for Life (which incidentally is a term that Darwin himself used as a synonym for the struggle for existence). In this chapter Hitler explained in detail his view that organisms, including humans, reproduce faster than the available resources and living space, so this makes the struggle for existence inevitable. In the limitation of this living space, Hitler asserted, lies the compulsion for the struggle for survival, and the struggle for survival, in turn, contains the precondition for evolution. (Adolf Hitler,Hitlers Second Book: The Unpublished Sequel toMein Kampf, ed.Gerhard L. Weinberg [New York: Enigma Books, 2003], 8)

The struggle for existence was a frequent theme in Hitlers speeches, too, and in a 1927 speech he clarified its significance in human evolution, stating,

You are the product of this struggle. If your ancestors had not fought, today you would be an animal. They did not gain their rights through peaceful debates with wild animals, and later perhaps also with humans, through the comparative adjustment of relations by a pacifist court of arbitration, but rather the earth has been acquired on the basis of the right of the stronger.

In a 1942 speech Hitler explained that Germany needed to fight wars to comply with the laws of nature. He then explained,This struggle leads in effect to an unswerving andeternal selection, to the selectionof the better and tougher. We thus see in this struggle an element of the building up of all living things. He then reiterated that struggle is a law of nature that produces progressive evolution. (Hitler,War der Zweite Weltkrieg fr Deutschland vermeidbar? May 30, 1942, inHitlers Tischgesprche, 492)

In Hitlers monologues he often broached the topic of evolution and the struggle for existence. For instance, in a long monologue about evolution, science, and religion on October 24, 1941, he was dismissive toward Christianity and clearly expressed support for evolution. At the close of the monologue he stated,

There have been humans at the rank at least of a baboon in any case for 300,000 years at least. The ape is distinguished from the lowest human less than such a human is from a thinker like, for example, Schopenhauer.

Otto Dietrich, Hitlers publicist, claimed that Hitler considered nature the source of the final truth about life. He took such principles as the struggle for existence, the survival of the fittest and the strongest, for the law of nature and considered them a higher imperative which should also rule in the community life of men. Dietrich also stated that Hitlers evolutionary views on natural selection and survival of the fittest coincided with the ideas of Darwin and Haeckel. (Otto Dietrich,The Hitler I Knew, trans. Richard and Clara Winston [London, 1957], 19, 153) Hitlers personal secretary, Christa Schroeder, concurred, stating that Hitler believed:

Science does not yet clearly know from which root human beings have arisen. We are certainly the highest stage of evolution of any mammal, which evolved from reptiles to mammals, perhaps through apes, to humans. We are a member of creation and children of nature, and the same laws apply to us as to all living organisms. And in nature the law of the struggle rules from the beginning. Everything incapable of living and everything weak will be eliminated.

OConnell and Ruse ignore all this evidence (and much, much more) that I have presented in my writings. Instead, they emphasize the valid point that anti-Semitism was crucial in Hitlers ideology, but Darwin never promoted anti-Semitism. True enough, but it misses the important point that no one certainly not me has ever argued that Darwinism contributed to anti-Semitism or that Hitler derived everything in his worldview from Darwinism. On the contrary, I have clearly argued in all my works that Hitler was an eclectic thinker who drew on many different intellectual influences some of them contradictory. He was influenced by the ideas of Schopenhauer, Nietzsche, Wagner, and many other thinkers, both well-known and obscure. (I examine many of these at length inHitlers Religion).

However, the influence of social Darwinism on Hitler was not minimal, because it was a key ingredient of many important Nazi doctrines, such as racial struggle, living space, militarism, eugenics, euthanasia, and more. Not only that, but as we shall see in my next post, these ideas of Hitlers were not just fringe ideas of people who had little understanding of Darwinian biology. Many Darwinian biologists and anthropologists promoted these ideas, too.

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Public goods – The News International

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The consensus is that the current pandemic will be with us for a long time to come. We will enter a period of intermittent outbreaks of Covid-19, whose precise characteristics are yet to be defined. There are no clear rules governing the interplay between our immune system and the mutations of the virus. We will have to live with uncertainty, however dramatic the advances in contemporary biomedical science.

Yet we know a few things for sure.

We know that the recurrence of pandemics is related to the dominant model of development and consumption, and to the associated changes in climate; to the pollution of seas and rivers and to the deforestation of forests.

We know that the acute phase of this pandemic the possibility of severe contamination will only end when 60-70 percent of the worlds population is immunised.

We know that this task is hampered by worsening social inequalities within and between countries, combined with the fact that Big Pharma does not want to give up patent rights on vaccines. Vaccines are already seen as the new liquid gold, succeeding oil, the liquid gold of the 20th century.

We know that state policies, political cohesion around the pandemic and public behaviour are decisive. The degree of success depends on the combination of epidemiological surveillance, infection reduction through containment, the effectiveness of the hospital back-up, better public knowledge about the pandemic and attention to special vulnerabilities.

Mistakes, negligence and even necrophiliac intentions on the part of some political leaders have given rise to forms of death-by-health policies that we call social Darwinism: the elimination of disposable social groups because they are old, because they are poor or because they are discriminated against for ethnic, racial or religious reasons.

Finally, we know that the European (and North American) world showed in this pandemic the same arrogance with which it has treated the non-European world for the past five centuries. Believing that the best technical-scientific knowledge comes from the West, it has been unwilling to learn from the way other countries in the Global South have dealt with epidemics and, specifically, with this virus.

Long before Europeans realised the importance of the mask, the Chinese made it compulsory. On the other hand, due to a toxic mix of prejudice and lobbying pressure from Western pharmaceutical companies, the EU, the US and Canada have relied exclusively on vaccines produced by these companies, with as yet unpredictable consequences.

On top of all this, we know that there is a geo-strategic vaccine war badly disguised by empty appeals to the well-being and health of the world's population. According to the science journal Nature, as of 30 March, the world needs eleven billion doses of vaccines (based on two doses per person) to achieve herd immunity on a global scale.

As of the end of February, orders for some 8.6 billion doses were confirmed, of which 6 billion were destined for the rich countries of the Global North. This means that impoverished countries, which account for 80% of the worlds population, will have access to less than a third of the available vaccines.

This vaccine injustice is particularly perverse because, given the global connections that characterise our time, no one will be truly protected until the whole world is protected. Moreover, the longer it takes to achieve herd immunity on a global scale, the greater the likelihood that virus mutations will become more dangerous to health and more resistant to available vaccines.

A recent study, which brought together 77 scientists from several countries around the world, concluded that within a year or less, mutations in the virus will render the first generation of vaccines ineffective. This is all the more likely the longer it takes to vaccinate the worlds population.

Now, according to estimates by the Peoples Vaccine Alliance, a global coalition of health and humanitarian organisations, at the current rate only 10% of the population in the poorest countries will be vaccinated by the end of next year. Further delays will result in a further proliferation of fake news the infodemic, as the WHO calls it, which has been particularly destructive in Africa.

There is consensus today that one of the most effective measures would be the temporary suspension of intellectual property rights on patents for Covid-19 vaccines by big pharmaceutical companies. Such a suspension would make vaccine production more global, faster and cheaper. Thus, more quickly, global herd immunity would be achieved.

Excerpted: Vaccines Must Be Treated as Public Goods Before It's Too Late

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Goat’s Milk Soap for Eczema: Potential Benefits and Precautions – Healthline

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The same ingredients in soap that break apart dirt and oils can also strip moisture and softness from your skin. To restore moisture, dairy ingredients like cows milk are sometimes added to the mix of your favorite bar soaps. Goats milk soap is simply a bar soap that has goats milk in the formula instead of cows milk.

Like other natural soaps, goats milk soap is made from lye thats mixed with fats and oils. In this case, the fats in the soap come at least in part from goats milk.

Since goats milk has a different molecular structure than cows milk, some people with a cows milk sensitivity prefer it. Goats milk may have some immune-boosting and other benefits if you drink it, and some people believe that using it topically in the form of soap can provide the same benefits for skin conditions like eczema.

Theres little research that proves goats milk soap will work to treat eczema.

Heres what we do know about using goats milk soap, including whether its a safe home remedy for children and adults with eczema.

Goats milk soap hasnt been extensively tested for use as an eczema treatment. Here are the proven benefits of goats milk soap and how they might play into eczema treatment.

Goats milk contains lactic acid, a naturally occurring and gentle alpha-hydroxy acid (AHA). Lactic acid is even in some commercial-grade skin peels because of how effective it is at exfoliating and encouraging cell turnover. Cleansing your skin with goat milk soap may help dissolve dead skin cells, revealing healthy, younger skin cells underneath.

Lactic acid from goat milk also contains probiotics. Oral probiotics using lactic acid bacteria have been shown to help treat eczema in infants. Since these probiotics found in the lactic acid found in goat milk was an effective topical treatment in infants, it might be worth a try.

Lactic acid doesnt just add probiotics and exfoliate your skin. Lactic acid in goats milk, combined with the natural fats and oils in the milk, are a natural humectant. That means that goats milk soap may strengthen your skin barrier and seal moisture in. Skin thats well-hydrated may be more resistant to eczema flareups.

Goats milk soap is generally considered safe for everyone. That includes the soft, extra-sensitive skin of babies and children.

Youll also want to look at the other ingredients. If you have eczema, you may be all too familiar with cosmetics, soaps, and beauty products that claim to be all natural but trigger your symptoms and inflame your skin. Also be aware of what type of oils are contained in the soap. At least one study indicates that olive oil can make eczema symptoms worse for babies.

If youre considering bathing your little one with goats milk soap, run it by their pediatrician, especially if your baby is less than 1 year old. Also, keep in mind that goats milk soap is not a replacement for any skincare product a doctor has prescribed for your baby to treat eczema or psoriasis.

Some kids might have sensitivity to goats milk soap, so use a small amount the first time to test it out.

Goats milk soap works great for some people, but it isnt for everyone. A study published in 2017 noted that using goats milk soap for inflammatory skin conditions, such as eczema, may increase your likelihood of developing an allergic reaction to consuming goats milk and goats milk products. Research also suggests that absorbing certain ingredients through a compromised skin barrier can lead to food allergies later on.

If youre interested in using goats milk soap for eczema, you have a couple of options.

First, you need to find the right products. Goats milk soap can be made from a powder base, or from fresh goats milk. Anecdotally, people who swear by goats milk for eczema prefer fresh goats milk for maximum benefits.

If youd rather test your skins reaction to goats milk soap (or if youre trying it out on an infant), you can simply add a little bit of the soap to warm water in the tub to create a soothing bath. Just make sure to keep it away from infants eyes.

Goats milk soap is more readily available in the United States than its ever been.

You can buy goats milk soap at health food stores, natural beauty suppliers, organic supermarkets, and some pharmacies.

Shop for goat milk soap online.

The evidence we have to support using goats milk soap for eczema is mainly anecdotal. However, theres research to support other benefits of goats milk soap for your skin, some of which are linked to eczema management.

For most people, theres little harm in giving goats milk soap a try to treat eczema symptoms. If you have a goats milk allergy, you may want to steer clear. Consult your childs pediatrician if you have questions about trying goats milk soap to help treat eczema for your child.

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Sarna Launches First-of-Its-Kind Whipped Foam Eczema Relief Therapy – PRNewswire

Posted: at 6:14 am

The Sarna Eczema Relief Whipped Foam helps heal eczema flare-ups and provides fast, soothing relief. Featuring eN2fused technology, a patent-pending matrix-infused technology containing millions of compressed gas microbubbles that rapidly expand when dispensed, the maximum strength formula helps to prevent transepidermal water loss and improve skin's natural protective barrier.

"Consumer demand has increased for more elegant formulations that absorb quickly into the skin without leaving unwanted residue," said Steve Gallopo, Crown Therapeutics Vice President, Global OTC Sales & Marketing. "Sarna has had tremendous success and is uniquely positioned to improve the anti-itch category. This first-of-its-kind whipped foamtechnology drives the brand to the forefront of best-in-class, innovative skin science solutions."

"Sarna has always been my go-to recommendation for patients suffering from dry, itchy skin and eczema," said Dr. Hadley King, Board Certified Dermatologist, "I'm thrilled to be able to offer a new, easy to use, fast-absorbing option that delivers the relief that my patients need, especially for those who want a more lightweight formula for everyday use."

Sarna Eczema Relief Whipped Foam is now available via Amazon.

1IQVIA Health

About SarnaSarna is the #1 dermatologist-recommended topical anti-itch brand1. Offering a unique variety of formulations, each product in the collection is designed to provide fast-acting, intensive relief and comfort to compromised skin without a prescription. Sarna products provide powerful itch relief and are safe for everyday use, containing no parabens, dyes or added fragrance. For more information about Sarna, please visithttps://sarnalotion.com/

About CrownCrown, a privately held, fully integrated global skin care company is committed to developing and providing a diverse portfolio of aesthetic, beauty, and therapeutic skin care products that improve the quality of life for its customers. An innovative company focused on skin science for life, Crown's unyielding pursuit of delivering therapeutic excellence and enhanced patient outcomes is why it has become a leader in Dermatology and Aesthetics. Crown has been listed on the Inc. 5000 Fastest Growing Privately Held Companies List for seven years and has expanded its distribution to over 38 countries. For more information about Crown or its products, visitwww.crownlaboratories.com.

SOURCE Crown Laboratories, Inc.

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Real-World Dupilumab Initiation Linked to Atopic Dermatitis Clearance at 6 Months – MD Magazine

Posted: at 6:14 am

A real-world assessment of dupilumab (Dupixent) show the biologic agent provides patients with atopic dermatitis consistent clinician- and patient-reported outcomes.

The interim PROSE registry findings, presented at the American Academy of Dermatology (AAD) Virtual Meeting Experience this weekend, complement a litany of clinical trials observing the interleukin-4 and -13 (IL-4; IL-13) inhibitor for atopic dermatitis.

Investigators, led by Jerry Bagel, MD, of the Psoriasis Treatment Center of Central New Jersey, sought the early trends of real-world initiated dupilumab treatment from the PROSE registryan ongoing, multicenter, longitudinal observational database enrolling atopic dermatitis patients treated with dupilumab in the US and Canada for up to 5 years.

Randomized dupilumab clinical trials have demonstrated rapid and sustained long-term efficacy with an acceptable safety profile in patients with moderate-to-severe atopic dermatitis; however, real-world data are limited, Bagel and colleagues wrote.

Their assessment of the registry did not include imputation for missing values. Eligible patients were initiating dupilumab as standard of care for diagnosed atopic dermatitis, but were able to receive marketed drugs as prescribed by clinicians for either their disease or a comorbid condition.

At the data cutoff of July 2019, 315 patients were enrolled. Mean patient age was 42.5 years old, with 44.8% being male, and 59.4% being White. Mean baseline Eczema Area Severity Index (EASI) score was 16.9; duration of atopic dermatitis was 19.7 mean years.

By month 6 of real-world dupilumab care, mean EASI score decreased to 4.4. Mean body surface area affected by atopic dermatitis dropped from 26.8% at baseline to 7.2% at 6 months.

Patient-Oriented Eczema Measure (POEM) scores decreased from 18.5 at baseline to 6.9 at month 6. Investigators additionally observed decreases in Peak Pruritus Numerical Rating Scale (6.9 vs 2.5) and Mean Dermatology Life Quality Index (12.7 vs 4.4) in the observed time period.

This real-world study demonstrates improvement in atopic dermatitis in adults over the initial 6 months of dupilumab treatment, using investigator-assessed and patient-reported outcomes, Bagel noted in his presentation.

The study, Early Trends of Disease Improvement in Adult Patients With Atopic Dermatitis Treated With Dupilumab: Real-World Data From the PROSE Registry, was presented at AAD VMX.

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LEO Pharma Receives Positive CHMP Opinion of Adtralza (tralokinumab) for the Treatment of Adults With Moderate-to-Severe Atopic Dermatitis – BioSpace

Posted: at 6:14 am

The CHMP positive opinion is one of the final steps before the European Commission makes its decision on the Marketing Authorization Application for use of Adtralza, an investigational therapy in clinical development, throughout the European Union. This final decision is expected in the coming months and if authorized, Adtralza will be the first fully human, monoclonal antibody available to specifically target the IL-13 cytokine, a key driver of atopic dermatitis signs and symptoms. Adtralza specifically targets IL-13 with high affinity and is developed to improve the symptoms of atopic dermatitis, which is a complex and chronic inflammatory skin condition.1,2

Atopic dermatitis is characterized by its unpredictability, which can be challenging for patients who often experience physical discomfort and emotional effects that may continue for decades, said Jrg Mller, Executive Vice President, Global Research and Development, LEO Pharma. Todays CHMP opinion brings LEO Pharma one step closer to the potential of providing Adtralza as a new therapeutic option for EU patients living with moderate-to-severe atopic dermatitis.

The CHMP opinion is based primarily on data from three pivotal randomized, double-blind, placebo-controlled trials (ECZTRA 1, 2 and ECZTRA 3), which evaluated the safety and efficacy of Adtralza as monotherapy and with concomitant topical corticosteroids (TCS) in more than 1,900 adult patients with moderate-to-severe atopic dermatitis. Primary endpoints were the Investigator Global Assessment score of clear or almost clear skin (IGA 0/1) and at least a 75% improvement in the Eczema Area and Severity Index score (EASI-75).3,4

Secondary endpoints, including the extent and severity of skin lesions, pruritus (itch), sleep and health-related quality of life measures, were measured by changes in the following scores: EASI-90, SCORing Atopic Dermatitis (SCORAD), Pruritus Numeric Rating Scale (NRS), Eczema-Related Sleep NRS and Dermatology Life Quality Index (DLQI). The trials demonstrated that Adtralza met the primary and secondary efficacy endpoints and was generally well tolerated.3,4

Pending the final decision from the European Commission, the marketing authorization will be valid in all European Union Member States, Iceland, Norway, and Liechtenstein. Additional regulatory filings are underway [with the U.S. Food and Drug Administration (FDA)] and other health authorities worldwide.

About Adtralza (tralokinumab)

Adtralza (tralokinumab) is a fully human, monoclonal antibody developed to specifically neutralize the IL-13 cytokine, which plays a key role in the immune process underlying atopic dermatitis signs and symptoms. Adtralza specifically binds to the IL-13 cytokine with high affinity, thereby preventing interaction with the IL-13 receptor 1 and 2 subunits (IL-13R1 and IL-13R2).1,2

About the pivotal ECZTRA 1, 2, and ECZTRA 3 Trials

ECZTRA 1 and ECZTRA 2 (ECZema TRAlokinumab trials Nos. 1 and 2) were randomized, double-blind, placebo-controlled, multinational 52-week trials, which included 802 and 794 adult patients, respectively, to evaluate the safety and efficacy of Adtralza (300 mg) as monotherapy in adults with moderate-to-severe atopic dermatitis who were candidates for systemic therapy.3

ECZTRA 3 (ECZema TRAlokinumab trial No. 3) was a double-blind, randomized, placebo-controlled, multinational 32-week trial, which included 380 adult patients, to evaluate the safety and efficacy of Adtralza (300 mg) in combination with TCS in adults with moderate-to-severe atopic dermatitis who are candidates for systemic therapy.4

About atopic dermatitis

Atopic dermatitis (AD) is a chronic, inflammatory, skin disease characterized by intense itch and eczematous lesions.5 Atopic dermatitis is the result of skin barrier dysfunction and immune dysregulation, leading to chronic inflammation.6 Type 2 cytokines, including IL-13, play a central role in the key aspects of atopic dermatitis pathophysiology.1

About LEO Pharma

LEO Pharma helps people achieve healthy skin. The company is a leader in medical dermatology with a robust R&D pipeline, a wide range of therapies and a pioneering spirit. Founded in 1908 and owned by the LEO Foundation, LEO Pharma has devoted decades of research and development to advance the science of dermatology, setting new standards of care for people with skin conditions. LEO Pharma is headquartered in Denmark with a global team of 6,000 people, serving 93 million patients in 130 countries. [In 2020, the company generated net sales of DKK 10,133 million]. For more information please visit http://www.LEO-Pharma.com

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LEO Pharma Receives Positive CHMP Opinion of Adtralza (tralokinumab) for the Treatment of Adults With Moderate-to-Severe Atopic Dermatitis - BioSpace

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Redness around nose: Causes, treatment, home remedies, and more – Medical News Today

Posted: at 6:14 am

The appearance of flushed skin around the nose varies from person to person. It can depend on the specific condition that causes it, how severe the irritation is, and a persons skin color.

Some people notice dry, itchy spots, raised or indented skin, or tiny blisters.

In people with dark skin, flushed skin around the nose may appear violet or purple. It may also be less noticeable, even when the rash is severe.

People with dark skin may also find that their doctors do not easily recognize the signs of various skin conditions. This may be due to dermatology textbooks that have focused on light-skinned patients.

For example, a 2020 study found that dermatologists might not recognize the skin manifestations of COVID-19 in Black patients. This can undermine their quality of care.

Learn about how rashes can look on dark skin here.

There are many different conditions or factors that could cause flushed skin around a persons nose.

Simply wiping the nose over and over can irritate the skin. This is especially the case during dry, cold months when the skin is more likely to be dry and irritated.

A person may notice that their skin looks red or purple, and the pain may worsen when they wipe their nose.

Some people develop mild allergic reactions to substances that touch their skin. Doctors call this contact dermatitis.

Irritant contact dermatitis irritates the skin but does not cause an allergic reaction. It may cause flushed skin and a raised rash, but the rash should not spread or cause a fever.

Causes of irritant contact dermatitis on the nose may include:

Symptoms of allergic contact dermatitis, such as a rash, may appear 2 days after a person has come into contact with an allergen.

Some causes may include fragrances and the preservative thimerosal, which features in some antibiotic creams.

Less commonly, a person may develop a life-threatening allergic reaction called anaphylaxis. This usually happens within a few minutes of exposure to an allergen.

Anaphylaxis may begin as a rapidly spreading rash. If a person sees a rash on their nose, they should check their body for bumps or other rashes.

Anaphylaxis is a medical emergency. If a person sees a spreading rash or has trouble breathing, they should call 911.

Rosacea is a skin condition that causes flushed skin and inflammation. While rosacea can affect any part of the body, it often begins around the nose.

A person might notice flushed skin, damaged blood vessels, tiny bumps, or changes in the shape of the nose. Rosacea is not dangerous, but it can affect a persons appearance.

In some people, rosacea may also be a sign of an underlying illness, such as an autoimmune disease.

Rosacea is more prevalent in people between the ages of 30 and 50 and in those with light skin. It is more likely to affect females than males.

Discover the best skin care products for rosacea here.

Eczema is a chronic inflammatory skin condition that causes dry, irritated patches of skin.

Sometimes the irritation is so severe that the patches crack open and bleed. Allergens and irritation can trigger an eczema flare, but dry skin is also a common culprit.

Redness around the nose may be eczema if it feels dry and itchy, looks white, red, or flaky, and worsens when the skin is dry.

Learn about what eczema can look like on black skin here.

A person can develop a sunburn just around their nose if they:

If the redness is flat and turns flesh-colored when a person presses on it, it may be a sunburn.

Sunburn may also feel dry and very sore. Severe sunburns sometimes blister.

Sunburn is a risk factor for skin cancer.

African American people have a lower melanoma survival rate than Caucasians. This may be due to delays in care.

Learn about how sunburn affects dark skin here.

An infection at the entrance of the nose called nasal vestibulitis can cause flushed skin and tiny, blister-like bumps around the nose and just inside of it.

A person may feel pain, swelling, and intense sensitivity. Some people develop a fever, though a person does not have to have a fever to have vestibulitis.

Nasal vestibulitis happens when bacteria enter the skin of the nose, often following an injury or infection. It can happen after a person trims their nose hairs.

Nasal vestibulitis is easy to treat, but it can spread to other areas of the body, so it is important to see a doctor.

Veins, which carry blood back to the heart, have valves in them to prevent blood from flowing the wrong way.

However, when these valves become damaged, the veins may look damaged and twisted. These are known as varicose veins.

Varicose veins often occur in the legs and feet. They especially happen in pregnant people and those who are overweight or obese. However, a person can develop varicose veins anywhere, including the nose.

The nose may look red, but when a person looks more closely, they might see tiny damaged blood vessels.

Learn 10 home remedies for varicose veins here.

Lupus is an autoimmune condition that causes the body to attack healthy tissue, leading to a wide range of symptoms and chronic illnesses.

Some people with lupus develop a malar rash, also known as a butterfly rash because it resembles a butterfly. This rash can cover the nose and cheeks.

In some cases, the butterfly rash may be the first symptom of lupus.

Learn about more symptoms of lupus here.

Infections of the skin can cause red, painful skin that may feel hot to the touch.

Cellulitis, one such infection, can begin with an injury even a small one. It might be as simple as dry, cracked skin. Bacteria gets into the deep layer of skin, called the dermis, and begins spreading. A person might notice flushed streaks, heat, pain, or swelling.

Bacterial skin infections can spread to other areas of the body, potentially even endangering a persons life. Therefore, it is important to seek prompt care.

See pictures of skin infections here.

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Redness around nose: Causes, treatment, home remedies, and more - Medical News Today

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Ebury to spice up the summer with Bunton’s ‘modern mum bible’ – The Bookseller

Posted: at 6:14 am

Published April 26, 2021 by Tamsin Hackett

Ebury Press will publish singerEmma Bunton's first book, Mama You Got This, on 10th June 2021.

Ebury Press will publish singerEmma Bunton's first book, Mama You Got This, on 10th June 2021.

Laura Higginson, editorial director, bought world all language rights from Severine Berman at The Mutha Ship.

Bunton is a mum of two and like most new parents, she juggled being a working mum, partner, friend, and trying to find time for herself, says the publisher. Although she had supportive friends and family, she found the endless rules and strict routines of most baby books overwhelming.

Mama You Got This is the book Bunton wishes she had readwhen she was a new mum.She will share the highs and lows she experienced,from post-birth recovery and no sleep to playtime and first smiles and share what she has learnt and some funny stories along the way. The author will also discuss her baby-care range Kit & Kin which she launched in 2017 after her child Tate suffered with chronic eczema.

The information in the book will be backed by experts including Yales paediatric sleep consultant Dr Craig Canapari, NCT breastfeeding expert Fran Bailey, mindfulness coach Heidi Fultonand midwife Marley Hall who will offer tips aboutsleeping, breastfeeding, weaning, crying, feeding, playing and self-care.

Higginson said: "Emma is known for being Baby Spice, full of girl power. I loved hearing about the very personal other side of her life and all those secret stories from being a mum whilst being one of the most famous pop stars on the planet. Her motivation for launching Kit and Kinto make a positive difference to baby-care and the planet is really inspiring and Emmas passion to write an equally positive, accessible modern guide is really exciting its a modern mum bible rich with relatable stories that will leave readers laughing, crying and feeling like whatever they are dealing with, they are not alone and there is help."

Bunton commented: "For my first ever book, writing about the most important part my life was easy. Opening up and sharing my stories feels totally natural with all you mums who are going through the same experiences but all in our own unique way. Becoming a mummy can be so daunting but we are in this together and we can support each other, dont you worry, mama,youve got this!"

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Ebury to spice up the summer with Bunton's 'modern mum bible' - The Bookseller

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