Daily Archives: March 26, 2021

Criticisms on Fridays: The Opera Managers Declare Themselves – OperaWire

Posted: March 26, 2021 at 6:29 pm

(Photo by Natasha Spencer)

Every Friday, Polina Lyapustina delivers a short essay on some of the mostsensitive topics in the industrywith the intent of establishing a dialogue about the opera world and its future.

On March 24, Opera Managers Association International issued an open letter, demanding solutions to the Global Culture Drain.

During a month marking one year of global quarantine, the association published a very balanced and smoothly written note, where, in 750 words, one barely finds anything to argue, though there are no certain points or solution either. And this probably made me read it between the lines.

In its statement, OMAI asserts that in countries with public support of the opera, artists are doing better, and the industry will certainly recover faster. This (without exhaustive explanation) sets the foundation for the solutions OMAI probably implies and expects. Meanwhile, not a single word is said on the optimization of the industry costs, improvement and update of the labor rights, and rethinking the art-form for the future.

The model in which state economics support (equally) different social and art institutions is Socialism. Though I believe, neither the worldwide tax increases (would you prefer 50 or 60 percent?) nor the abolition of private rights are in the plan. But surely, OMAI didnt mean to change the political systems in the countries around the globe. Giving Germany as an example, the authors of the letter seem to forget, that not only arts but all entrepreneurs and workers received the same type of support. At the same time, German opera freelancers are now fighting with opera managers, who denied them fair payments for the real work.

So many problems were finally surfaced in the last year. They are now no probable but well-known issues to solve. But instead of coming up with solutions, OMAI demands support. As if no one did it before.

Left without their usual work, managers dont ever try to find new ways, though they certainly understand, its their duty:

Can the industry survive this? Opera has existed for over 450 years and has survived many global crises. But what the future will look like when the curtains reopen is uncertain.

Opera Managers Association International (OMAI) was founded to address these questions.

From the complete absence of even the slightest mention of innovative solutions in the letter, we can conclude that, unfortunately, no matter where money and support would come from, its clear that OMAI wants to return to the old state of the opera industry. The one with big stagings and bloated budgets made of gold and glitter but not able to sustain itself. The industry in which artists need government support in difficult situations.

Well, in lieu of the fact that they still wont say it, I will.

Sounds like a lot of work for the managers, doesnt it? Lets admit, we certainly need qualified managing staff for this. But will this work be well-paid in the new reality? Is there, in a better developed and sustainable opera industry, lets say it honestly, a place for managers who make major proclamations and call for support but have no substantial ideas for getting it?

In conjunction with the open letter of Opera Managers Association International, Im asking directly, shouldnt the demand for public support which undoubtedly brings temporary relief, be combined with efforts to make the opera industry smarter, more independent, and maybe even more grounded? That way, in the face of a new crisis, it would be more sustainable and less fragile, making empty letters like this one unnecessary.

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Difficult Conversations: Navigating Politics at Yale and Online – Yale Daily News

Posted: at 6:29 pm

Valerie Pavilonis

On March 12, Ryan Schiller 22 woke up from a nap around 11 p.m. to a random ping on his phone from the app, Clubhouse. The social network, which relies on audio-chatting in themed chatrooms similar to large conference calls, notified him of a conversation with Yale-affiliated moderators entitled Abolish the Ivy League.

Schiller joined the chatroom, where he was invited to introduce himself to the crowd of listeners as a Yale student. In his introduction, Schiller says he briefly spoke about his co-created app, Librex a mobile app created in September 2019 that allows Ivy League students to anonymously discuss campus culture. About five minutes after his introduction, Schiller says a few other current Yale students came to the chatroom to talk about the apps limitations, in what would develop into a more than 2-hour debate in front of more than 800 listeners. At the helm of this conversation were questions regarding the first amendment, censorship and if college students can establish meaningful relationships with peers across the political spectrum.

All eight students who spoke with the News mentioned discussion as an effective tool for fostering relationships across political lines. But four students were wary about political polarization on campus and five students identified concerns over debates related to identity or civil rights.

Is the Personal, Political?

For Jasper Boers 22, at the heart of polarization on campus is when the personal becomes too political. This can oftentimes lead to broken friendships, anger and lost time at the University, he said. There are people who view politics as part of their identity, but ultimately debate will not always end in compromise, Boers added.

I dont think we should be aiming for a political University, he told the News. While its great that some of these students want to engage in politics, I think four years at Yale are quite short.

Jordi Bertrn Ramrez 24, a member of the Endowment Justice Coalition, told the News that more conversations need to be had with patience and empathy when discussing any political divides. He added that fundamental shifts in value[s] dont happen overnight, and it is best to assume benevolence. But Bertrn Ramrez said the ability to separate the personal from the political is a privilege for some, and that oftentimes marginalized communities turn to protest because they feel there is no other way to communicate with people in power.

When were talking about issues that are about civil rights and creating spaces that are accessible, focusing on debate as being the only and primary source of value debate isnt perfect, Bertrn Ramrez told the News. If I dont know how to argue with you that I deserve my rights, that doesnt mean I deserve my rights any less.

Emma Knight 22, co-Leader of the Yale Political Union, said that it was okay not to always engage in cross-partisan discussion, especially when the debate might involve civil rights.

Not everyone wants to (or even can) seek out intense cross-partisan discussion all the time, and I honestly think thats okay, Knight wrote to the News in an email. Political debate can be exhausting, especially when issues involve ones own rights or identity. I know that I am privileged in many ways, which has contributed to my positive experience with fruitful discussion on campus, and I want to acknowledge the fact that not everyone has had the same experience.

Knight highlighted the parliamentary procedure debate format in the YPU, a debate society she felt has a wide range of ideological backgrounds. Though the format which includes student speakers giving three-to-five minute speeches on carefully chosen topics may seem odd to first-timers, Knight said the unique format helped to emphasize a high standard of conduct. She said that the YPU also seeks to foster relationships outside of a debate setting, so that members can learn to appreciate each other beyond their political beliefs.

Politics in the classroom and on campus

Boers the student president of the William F. Buckley Program thought more engagement was needed in University classrooms.

The Buckley Program seeks to expand political discourse on campus by hosting events, such as debates between two scholars from opposite sides of a given issue. The success of the program high attendance at events and lots of programming shows there is a real appetite for education and participation on issues that are polarized to a certain extent, Boers said. But he emphasized that the organization is not meant to replace discourse that should take place in classes or the broader University.

The real intellectual diversity is, and sort of has always been, in the classroom, Boers told the News. The real thing that students, I think, if they want intellectual diversity ought to be pushing for is a greater representation in Yale classes.

On campus, Boers said that in challenging classes, he found there to be much more of an emphasis on the collective mission of the students to engage with difficult texts. Political disagreements start to dissolve as everyone is working towards understanding the readings.

James Hatch 23 who is an Eli Whitney student and veteran expressed similar sentiments about his first year around a seminar table, discussing challenging books with students who came from different backgrounds.

My philosophy professor from first semester, he said Good leaders are bridge builders, Hatch told the News in an interview. Thats what I see in my classmates I think that academia could be and it should be the place where the example on how to conduct yourself when discussing different, sensitive and difficult issues Yale College should be that.

I think generally in terms of classes with Yale professors, theyre pretty open to most ideas, Ryan Gapski 24, outreach director for the Buckley Program, told the News. I think most students are pretty reasonable too.

Jaelen King 22, the Executive Director of the Black Students for Disarmament at Yale, echoed similar sentiments. The organization is still working to meet with campus groups who have traditionally opposed police abolition, which is BSDYs main goal.

King said that lived experiences, family history and traditions all contribute to the way people think. There is no inherent hatred, King said, and even if he may not agree with one of his peers, the best course of action is to talk it out and understand where the other person is coming from.

Im just a firm believer in the relationships and the power of love and the power of people connecting, more than the idea of an idea being objectively right, or a universal truth, King told the News. But more just like caring about the person enough to work towards coming to a compromise, agreement or forgiveness pattern.

King said its easy to fall into a social niche and stay there at Yale, and that it was up to students to be intentional about stepping out of these spaces to better empathize with others.

Censorship and Social Media

Schiller has described his app, Librex, as one answer to the lack of complex conversations being held amongst Yale students. During the Clubhouse call, he introduced his purpose for creating Librex: to create conversation within campus communities. He added that he wanted people to talk about important issues and connect with one another in an authentic and vulnerable way.

Those couple minutes that I was listening turned into two hours, maybe even more, of me just fully involved in this conversation, Fatma Elsayed 23 told the News in an interview about the Clubhouse chatroom. [I was] explaining to them the context around Librex and having this wider discussion on free speech, which I think is definitely one of the most debated topics about college campuses. But I think sometimes when we talk about free speech, we dont consider what that conversation means for people of color.

Elsayed joined the call to highlight previous harmful posts on the app, which Schiller told the News were from last July and have since been taken down. During the call, Elsayed also opposed the idea that Librex was a solution, or way for us to have invigorating debates that were meaningful at Yale due to the apps anonymity.

College campuses dont need Librex, she told the News. College campuses need classrooms, discussions and debates where people are actually talking face to face.

But Schiller defended the apps anonymity feature, in part because he remembered times when his friends felt the need to self-censor in classes or were excluded from social circles. We all need social communication and want to fit in, he added, which led some of his friends to realize it may not be worth it to openly express their political views. At the crux of the Clubhouse conversation, Schiller said, was a tension between censorship and trusting college communities to be positive through debate and conversation on the app.

Librex has gone through a number of changes since its first inception. From the beginning, users could only access the app with authenticated credentials such as university email addresses, and Schiller said the app has always had the ability to ban users. Over time, the app has expanded security measures by increasing the number of student moderators on each Ivy League server. Schiller, who doubles as a Yale moderator for the app, said the student moderators are provided with access to a moderation interface and are push notified each time a post is reported. He added that, as an app with community standards, if enough people report a post, it is automatically removed. As one of the apps creators, Schiller said he is in constant communication with student moderators across schools and that Librex surveys its users once per quarter.

Schiller mentioned a previous experience where the app had to re-examine its policies the May 2020 student elections at Dartmouth.

On the Dartmouth server, only accessible by the Dartmouth community, there were reports of public attacks or condemning of student candidates on the anonymous app. Librexs previous policy stated that private information, names or the divulging [of] details about peoples personal lives was prohibited for non-public figures such as students. But initially, where candidates for student office fell in the two categories was unclear.

Schiller said that since then, the Librex team voted to remove the posts and updated the rules regarding non-public figures in the context of campus elections. He reflected that there were some posts that went too far. For him, addressing those posts was a learning experience to help him and others figure out the bounds between whats civil and whats divisive.

Schiller acknowledged that there have also been posts on the Yale feed that have gone too far and mentioned the security measures currently in place and the road of development ahead.

Theres always so much work to be done, and theres so much we want to make and so much we want to improve about the app and school community in general, Schiller said.

According to Hanah Jun 23, if someone makes a hateful comment, accountability could mean the ability of other students to a) respond to the comment and/or b) disaffiliate with the person who made the comment. Currently, students can comment underneath posts but all posts are anonymous.

Still, Jun, who also tuned in to the Clubhouse call, said that maintaining ethics on Librex and all forms of social media is easier said than done.

Jun recounted her comments made in the chatroom, whose audience she characterized as having a diverse familiarity with the app.

I was commenting that accountability would be harder to enforce on an app like Librex where posts are anonymous, Jun told the News in an interview. Free speech should be allowed, but there should be some mechanism of accountability.

She added that if hateful speech leads to hateful actions, there should be consequences to a degree. But she emphasized that accountability looks different for each case.

Theres a fine line, Elsayed said. But I also think there are some cases were its very clear.

Knight said that yes, there is a fine line between a controversial take and an offensive take but said people always disagreed on where that line landed.

The Bigger Picture

In general, Jun said, users lose the humanistic aspects of discourse when it is shifted to an online platform. She added that it has some real psychological effects, like people being less respectful of each other and debates spiraling out of control.

Knight wrote that this semester leadership has been working on systematizing the process for responding to harmful comments made on the YPU debate floor. Given our polarized climate, people sometimes dont know about certain dog-whistles or historical contexts, her email read. She added that almost always, harmful speech is unintentional. Four other students agreed.

But Knight noted that regardless of intent, harm needs to be taken seriously to preserve and advance the inclusivity of YPU spaces. Though it is difficult and different depending on each case, doing so means initiating restorative and educational conversations following incidents in order to find understanding about the roots of the disagreement, she wrote.

For Bertrn Ramrez, the origins of contention is where conversations must begin if students are to cultivate long-lasting relationships.

When I sit and I think, what is the root, the fundamental seed of what I care about, what that is is people deserve to be treated with respect and care, and people deserve equitable treatment, Bertrn Ramrez said. But that is already a contested belief, and so the very seed of my activism, the very seed of my advocacy, to some people is already contentious. Thats where the problem starts, and thats where I think the conversations need to begin.

Zaporah Price | zaporah.price@yale.edu

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Herman: The Texas GOP. There’s no fight like a family fight. – Austin American-Statesman

Posted: at 6:29 pm

These are encouraging days for Texas Democrats. Oh, theyre still the semi-lovable bunch that hasnt won a statewide race since prior to the turn of the century, and the party is coming off its most disappointing election cycle in many a cycle.

But the good news for folks in this bunch is that folks in the other bunch are fighting among themselves. As you might remember from family Thanksgivings (remember family Thanksgivings?) there's no fight quite like a family fight. They can be relatively destructive.

OK, lets check the GOP fight card as we see if the Republicans indeed are getting ready to rumble among themselves. Lt. Gov. Dan Patrick is not happy with Gov. Greg Abbott about post-freeze energy legislation. Patrick also seems crosswise with House Speaker Dade Phelan on this life-and-death topic.

Also, lots of Republicans remain upset with Abbott over his handling of COVID-19. Lots of Dems also are upset with Abbott over this, too, but for diametrically opposed reasons. The unhappy Repubs believe Abbott has been too restrictive. Just the opposite for Dems who are unhappy with the governor.

And now Agriculture Commissioner Sid Miller, whos been among the Republicans unhappy with Abbott over pandemic policy, is hauling Patrick and the entire GOP-controlled Texas Senate into court to challenge the Patrick-backed Senate rule requiring COVID-19 tests for anyone who wants to get into the Senate chamber, its upstairs gallery or committee hearings.

And on Thursday, Miller blasted out an email to supporters that included this: "Please contactGovernor Abbott at 512-463-2000 and ask him what he intends to do about the Chinese communist takeover of 180,000 acres of strategically sensitive Texas land because, right now, it looks like the answer is 'not much.'"

Also this week, as if we needed further evidence of the GOPs internecine unpleasantries, several Republicanshave formed a new organization aimed at steering the party away from what the new group sees as a self-destructive path. Its an intriguing effort that calls itself the Texas Republican Initiative and announced itself with a statement headlined, The Republican Party of Texas has lost focus, results could be detrimental to Texas.

Its a clear effort to overcome the influence gathered by a further-to-the-right wing that has nosed its way into leadership posts. The new group is "encouraging Republican voters to become more involved in the party, a nod to the notion that the party harbors a silent majority that should fear permanently losing the party to a noisy minority.

Former Texas Secretary of State Carlos Cascos, who was an Abbott appointee in 2014, is president of the new group. Hes also a former Cameron County judge and now serves on the State Republican Executive Committee. He's also mulling a run for the seat being vacated by retiring U.S. Rep. Filemon Vela, D-Brownsville.

We must not be distracted by small, albeit vocal, groups that desire to pivot the partys focus to issues that are not representative of all Republicans, let alone most Texans, Cascos said in announcing the new initiative.

The groups veep is Cameron County GOP Chair Morgan Cisneros Graham, whoin the announcementreferred to growing concerns about the direction of the party. … TRI intends to address these concerns by focusing on the successes of Republicans, not by kicking out Republicans.

Graham also offered this damning analysis of the state of the state party: Currently, the Texas GOP has resorted to being a promotional vehicle for a handful of people to pursue bigger things versus a functional organization that is in charge of supporting and promoting Texas Republicans. Fundraising, outreach and basic organization have been ignored, which will result in Republican losses ... unless something is done.

Its a shot at Texas GOP Chair Allen West. Ill let you decide how veiled a shot it is. For his part, West is planning to be in Laredo on Friday to discuss legislative progress on the partys priority issues, which include election integrity, religious freedom, children and gender modification, abolition of abortion, constitutional carry of firearms without permits, monument protection, school choice for all and a ban on taxpayer-funded lobbying.

Brewing elsewhere on the GOP intramural front, indicted and embattled Texas Attorney General Ken Paxton has called in out-of-state reinforcements for what he sees as a legislative battle (in a GOP-dominated Legislature) for funding for his office for what he clearly thinks is the highest and best purpose of a Texas attorney general.

My agency is better positioned than anyone in the country to beat the Biden agenda, he tweeted Wednesday. This natl network of conservative champions understands that. Fellow Texans: Ensure your legislator is FULLY RESOURCING my office. Any cuts are a loss for TX and in turn a loss for USA.

Ken Paxton, Americas last best hope.

Attached to the tweet was a letterfrom the Conservative Action Projectto Patrick, Phelan, Senate Finance Chair Jane Nelson, R-Flower Mound, and House Appropriations Chair Greg Bonnen, R-Friendswood, to applaud the work Texas is doing to stand up for conservative causes nationwide. Much of this work has been done by Texas Attorney General Ken Paxton, whose office has been a crucial force in protecting the country from government and constitutional overreach.

Any reduction to the Office of the Attorney Generals budget will result in tremendous harm to the state and nation, the out-of-staters told state budget writers. The cause of liberty and justice cannot afford that.

Among the signatories are former U.S. Attorney General Edwin Meese and other conservative stalwarts, including Kelly Shackelford of the First Liberty Institute and L. Brent Bozell III of the Media Research Center.

Now we wait to see how these battles play out. Im guessing Millers lawsuit against Patrick and the Senate will get dead-ended in a judicial branch that tends to be very hesitant to get involved in how the legislative branch does its thing. Andif the courts decide to rule on the merits of the lawsuit, I see a solid chance of a ruling that the COVID-19 restrictions are a reasonable response to an extraordinary situation.

Theres going to be plenty to keep an eye on as the legislative session progresses and the Repubs running the show navigate their differences as they position themselves for the next elections. The differences are so pronounced that Patrick recently pronounced this: One question I just want to make clear, because it's been in print because the media likes to do this: I am not running against Greg Abbott. OK? I'm not going to run against Greg Abbott.

The broader question confronted by the Texas GOP is the same one confronted by the national GOP. Is what we see now, including fringe rule focused on fringe issues, what were going to get for years to come from the Republicans?

Or, as the new Texas Republican Initiative seems to want, can it revert to being an important voice with important input on the real issues of the day?

Texas and America need the latter.

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Pandemic-related disruptions to schooling and impacts on learning proficiency indicators: A focus on the early grades – World – ReliefWeb

Posted: at 6:29 pm

This paper was written by Martin Gustafsson

SUMMARY

The United Nations Secretary-General, Antnio Guterres, echoed the concerns of people and organisations around the world when he recently referred to the impact of the COVID-19 pandemic on schooling as a generational catastrophe. Children and youths are falling behind in their learning, and this is expected to have an impact lasting decades, especially if longer term effects on economic development and future earnings are taken into account.

This report focusses on the impacts of the pandemic on learning proficiency, specifically as measured by Sustainable Development Goal (SDG) Indicator 4.1.1. Over the last couple of decades, there has been a growing awareness of how crucial learning proficiency, especially that of younger children, is for human development. The evidence is clear that improvements in proficiency underpin future economic development, and the building of more cohesive and equal societies. The indicators on learning proficiency are among the most discussed indicators within the SDG framework.

There have been a number of attempts to understand and quantify the learning losses caused by the pandemic, with a view to shaping the necessary mitigation strategies. The current report represents one such attempt. What was clear around the end of 2020, when the pandemic was still far from over, is that the effects of the pandemic on schooling and learning were large, yet it was still too early to gauge precise effects. Moreover, while education actors around the world have responded to the crisis in often heroic and innovative ways, the optimal approaches to mitigating long-term impacts remain unclear. The pandemics threats to education are unprecedented in their nature and magnitude. While a wealth of evidence on how learning occurs, and what improves educational quality, is enormously helpful in charting the way forward, a greater understanding about the specificities of the pandemic and schooling is needed.

This report brings certain important specificities to the fore. This is done in a manner which emphasizes issues education planners would be familiar with, and need to grapple with. Though the model developed for the current report uses country-level data, the aim is not to provide guidance to individual countries. Rather, this report aims to provide global projections, and to identify dynamics which planners must focus on. These include: the magnitude and nature of the pandemic-related disruptions, not just to schools, but also pre-school institutions; the relationship between disruptions in the contact time of learners and losses in learning proficiency; the movement of age cohorts through the schooling system, and what this means for future proficiency levels and recovery strategies; what recovery means in terms of accelerating learning, and the point at which one can expect a return to trajectories envisaged before the pandemic.

The model producing the projections, in an Excel file, uses as its point of departure a projection model published by the UNESCO Institute for Statistics (UIS) shortly before the start of the pandemic. A key input in the new model is the contact time with teachers that children have lost, per country, from February to November 2020, expressed as a percentage of the regular school year. These statistics take into account partial closures, including situations where schools are open but attendance occurs on a rotational basis. By 11 November, the average child had lost 54% of a years contact time. Time lost is then converted to a fraction of a year of learning lost. Evidence, both from before and during the pandemic, point to an important effect: interruptions in contact time lead to learning losses which are larger than what is suggested by the actual time lost. This is because learners tend to forget skills acquired even before the interruption. A forgetting ratio of 2.0 is used in the model: for every month of contact time lost, two months of learning are assumed to have been lost. A value of 2.0 is in line with the limited evidence we have on the magnitude of the ratio. Thus, if on average 54% of the school year has been lost, just over a years learning will have been lost on average. The model takes into account the fact that a years learning is not the same across the world: countries which perform relatively poorly in internationally comparable assessments, do so because the amount of learning occurring between one grade and the next is lower. The model assumes that learning losses in each country are coupled with worsening inequality: learners who performed well previously, and would often be socio-economically advantaged, experience smaller learning losses than learners who did not perform well previously.

Beyond 2020, the model assumes learners moving into, for instance, Grade 6 will continue to be less proficient than what could be expected without the pandemic, because these students lost learning in a previous year. In fact, without any remedial acceleration, or catching up, Grade 6 learners up to 2025 would all be equally behind in 2025 children who were in Grade 1 in 2020 would reach Grade 6. But the model assumes that even beyond 2025, Grade 6 children would display the effects of the 2020 disruptions, because these disruptions affected pre-schools too. Though the data on pre-school disruptions in 2020 are very limited, it appears pre-schooling was as disrupted as schooling in Grade 1 and above. The model draws from UIS data on pre-school participation to gauge the probability within each country of pre-school disruption effects having been felt when children enter school.

What is also taken into account is the possibility that children who were in utero during 2020 could experience exceptional cognitive development difficulties. This draws from evidence that a social and economic shock such as the pandemic can have a lasting impact which is especially large for children who were in utero during the shock. While in many countries these effects may not endure beyond a few years, it nonetheless seems important to bear in mind within any projections which age cohorts of children were in utero during the onset of the pandemic.

The trajectory which has just been described is illustrated by the red curve in the following graph, which focuses on Grade 3. The red curve represents the worlds children in Grade 3, drawing from the data of individual countries, and assumptions such as the 2.0 forgetting ratio discussed above.

In 2019, around 59% of the worlds approximately 132 million children who should be in Grade 3 were proficient in reading. Thus, 54 million children in 2019 were not reading as they should. The 54 million includes roughly 12 million children who were not attending any form of schooling in 2019, who are all considered non-proficient for the purposes of this analysis. The figures for proficiency in numeracy would be similar. It is estimated that the learning losses associated with the pandemic would reduce the percentage of proficient children at the Grade 3 level to 49%. This means the number of non-proficient children at this age would increase from 54 million to 68 million the pandemic would push 14 million children at just the Grade 3 level below the proficiency threshold.

The red curve points to a return to the original proficiency trajectory for Grade 3 only in 2030. The grey and black curves reflect scenarios where there is successful catching up, or remediation, in the form of more learning than usual. For instance, the grey curve represents an acceleration of 10% a year. This means learners would need to learn 10% more than a normal years worth of learning, in order to catch up to where they would have been without the pandemic. In that scenario, a return to the previously envisaged trajectory would occur earlier, in 2027. Accelerating learning, especially in developing countries, has been on the agenda for many years, and there is now considerable research to inform optimal strategies. At the same time, it should be kept in mind that acceleration to take a schooling system to new levels of proficiency is not the same as acceleration to recover from a loss in historical levels of proficiency. The latter is likely to be easier to achieve as teachers and administrators are familiar with the desired end result, and are very likely to see it as desirable and achievable.

In the original trajectory, represented by the green line in the graph, gradual but ongoing improvement was envisaged. This is based on earlier projections released by the UIS, which draw from evidence of learning gains seen in international testing programmes. The graph serves as a reminder of an important matter. Countries which were experiencing ongoing improvement before the pandemic need to ask themselves what factors were driving this. These factors, which are likely to be linked to the quality of training of new teachers, support to all teachers, and accountability systems, should continue to receive attention. Planners need to balance the focus on remediation programmes aimed at addressing the learning losses, against a continued focus on other drivers of long-term development. Put differently, while addressing the pandemic-related learning losses, countries should also strive to ensure that new learners entering school, who would not have experienced disruptions, though they may have experienced pre-school disruptions, reach levels of proficiency close to those seen before the pandemic or, even better, in line with a countrys previously envisaged improvement trajectory.

Projections for the end of primary and end of lower secondary levels are also provided in the report. At these levels, similar dynamics apply, but a return to a pre-existing trajectory occurs around three years later for the end of primary and five years later for the end of lower secondary. These lags can be shortened with the right learning acceleration.

Projections from the three levels analysed Grades 3, 6 and 8 permit an estimation of how many of the 1.06 billion children across eight age cohorts, corresponding to Grades 1 to 8, would move below the proficiency threshold as a result of the pandemic. The number of children of these ages falling below the threshold would increase from 483 million to 581 million in 2020. The pandemic would push just under 100 million children below the proficiency threshold. This number excludes children who would carry learning losses with them into Grade 1 as a result of disruptions to pre-schooling, and adolescents in schools and post-school institutions above Grade 8 who would suffer the educational effects of the pandemic.

There are key challenges which are not captured in the above graph. One is that education budgets are expected to decline as a result of the economic effects of the pandemic. This will compound the problems, especially if teachers feel they are bearing more than their fair share of the budget cuts, and if spending on teachers puts pressure on spending on educational materials. Reductions in spending on school meal programmes could have very serious negative consequences for the physical and cognitive development of children from poor households. The report discusses these matters, which are to some extent within the control of education planners.

What education planners have little control over is the economic effects of the pandemic on households, the most serious effect being a worsening of poverty. One result of this could be an increase in the percentage of children not in school. Little is known at this stage about the likely magnitude of this. While poverty may make it more difficult for households to send children to school, reductions in child labour, the abolition of school fees in many countries and increases in the coverage of school meal programmes in the last two decades are all factors which would work against higher levels of dropping out, especially for younger learners.

Tragically, increased dropping out is unlikely to affect the SDG proficiency indicators to a large degree. This is because those countries where more dropping out is most likely are also countries where children had low levels of proficiency even before the pandemic. In sub-Saharan Africa, in particular, only 20% of lower primary children are proficient in reading, yet 81% of primary-aged children are in school. Given the strong links between socio-economic background and learning, one can roughly say that outside the middle class, few learners in this region become proficient. And given that the poor are most likely to drop out of school, the result would be more non-proficient children outside school and fewer non-proficient learners in school. Clearly, even if more dropping out does not have an impact on the SDG proficiency statistics, the matter is a serious one in terms of, for instance, child nutrition and psychological well-being. Moreover, there are degrees of non-proficiency. Children should be as close as possible to the level of proficiency they should ideally be at.

Of the previously mentioned figure of 100 million children across eight age cohorts who would move below the proficiency threshold, 34 million would be children in Central and Southern Asia, while 29 million would be in Eastern and South-eastern Asia. These would be the two worst affected regions in absolute terms. In terms of percentage point changes in the percentage of proficient children, the largest decline is seen in Latin America and the Caribbean from 70% to 51% in Grade 3, for example. Sub-Saharan Africa sees rather small declines. This is because even in 2019, the percentage of children who were proficient was low for instance 20% at the Grade 3 level. Much of the learning losses occurring in this region would occur among children already below the level of proficiency. Put differently, the SDG indicators on learning proficiency provide a rather limited picture of the impacts of the pandemic on learning in sub-Saharan Africa.

Countries with effective programmes to monitor progress in, for instance, early grade reading will be in a good position to compare likely future trends without the pandemic, to actual outcomes with the pandemic, of the kind presented in the current report. Such comparisons will assist in determining what the effect of the pandemic has been on learning outcomes, and what remediation seems best. Countries which do not have these monitoring programmes will find it harder to interpret what lies behind the unusual trends which can be expected in the coming years. In particular, such countries may find it difficult to determine exactly how large the initial learning losses of 2020 were. The shock to learning brought about by the pandemic should be a catalyst for building back better, specifically improving the monitoring of learning, and taking teacher training, support to schools, and school accountability systems to new levels.

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Welfare system in need of reform | Barbados Advocate – Barbados Advocate

Posted: at 6:29 pm

THE countrys welfare system needs to be reformed and now may be the time to give it the attention it deserves.

Member of Parliament for St. James North, Edmund Hinkson, raised the matter as the Estimates Debates continued on Wednesday. Hinkson stressed that the COVID-19 pandemic presents an opportunity for the reformation and transformation of our economy and society and hence, he spoke of a few areas in need of change.

While thanking Minister of People Empowerment and Elder Affairs, Cynthia Forde, for the work she has been doing to assist those in need, even this year, coming to the assistance of fire victims in his very own constituency, Hinkson however said that the Welfare system, which falls under her Ministry, needs some tweaks.

Our Welfare system, and again the time is now, needs to be reformed. I know that there is a Committee of Cabinet looking into that. I believe it is headed by the Honourable Member for St. Michael South Central, (Marsha Caddle), but we cant continue with a situation where there is so large intergenerational welfarism, where someones grandmother has been on welfare, the parents and now them. This will require of course a whole of government, a whole of society approach to the issue, but it has to be tackled, Hinkson

remarked.

We have to move away from our peoples dependence on welfare. I believe, Sir, that the department should carry a new name to start with, a new reformation, maybe the Human Development Department or the Social Development Department would help, but the reality is that our educational system and many ministries have to be involved in this approach as well, he further stated.

To this end, Hinkson also called for curriculum reform in the education sector to assist in this effort.

Our Ministry of Education is again led by an extremely able Member of Parliament for St. Michael South East (Santia Bradshaw), who brings to her ministerial task passion and commitment to effect change, but the time is now to effect this change. We need of course curriculum reform. We havent had that for 20 years now. That is paramount. We cannot continue under the system that we now have, which of course was founded still on a colonial system, he commented.

Acknowledging that every child will not be academically inclined, but that every child has worth and skills, Hinkson voiced his support for the abolition of the Common Entrance Exam, which his government has spoken to. He also noted the need to create greater opportunities for young people to be engaged and for those who are not so academically inclined, to have greater access to technical and vocational opportunities to develop their skills, so as to ensure that the reform needed in the welfare system can take place. (RSM)

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Blackjack Online: 21 Best Sites to Play Blackjack (Live Dealers, Real Money, or Free Blackjack Game Options) – Yahoo Finance

Posted: at 6:28 pm

DETROIT, March 23, 2021 /PRNewswire/ -- Leanbackplayer.com announces the release of the review "Best sites to play Blackjack online'

Blackjack is a wonderful game. It's easy to learn but allows for quite a bit of strategy, and it's one of the games in which the house has the smallest edge.

Unfortunately, there's one small problem with it: in most cases, you need to live near a casino in order to play it for money.

At least, that used to be the case. Thanks to the power of the internet, though, it's now possible to play blackjack online for real money.

If you've ever found yourself playing cards in a shady casino, though, then you already know that not every cardroom should be trusted with your money.

With that in mind, we've put together a list of the best sites on the internet for betting on blackjack.

Best online blackjack sites by category:

1. Best welcome bonus: Ignition Casino 2. Best live dealer blackjack: Super Slots Casino 3. Best for free games: Red Dog Casino 4. Best loyalty bonuses: Intertops Casino 5. Best variety of games: Wild Casino 6. Best for unique games: Las Atlantis Casino 7. Best mobile gaming experience: Slots.lv 8. Low wagering requirements: Bovada Casino 9. Best for tournaments: Black Chip Poker 10. Best VIP program: Americas Cardroom

Runner ups for top online blackjack sites:

11. Jackpot City 12. Royal Vegas 13. Ruby Fortune 14. Cafe Casino 15. BigSpinCasino 16. Juicy Stakes Casino 17. mFortune Casino 18. Mr Spin Casino 19. Casino.com 20. CasinoRex 21. Ladbrokes

Ranking Methodology for Best Online Blackjack Sites

When assembling a list such as this, it's important to have a clear methodology behind your rankings. We're not just using our opinions here we're looking at the following objective criteria.

Game selection: a lot of sites offer regular blackjack. We looked for casinos that had a wide variety of games to ensure you never lose your thrill.

Trustworthiness: is the site playing fair? Will they give you your winnings when it's time to cash out? Needless to say, shady blackjack sites didn't make the cut.

Bonuses: many sites offer bonuses, loyalty programs, and other benefits for playing with them. We looked for the sites that offered customers the most free money.

Interface quality: if you're going to be spending a lot of time playing blackjack on a site, you want that site to be attractive and easy to use. After all, the last thing you want is to make an expensive mistake because the layout is confusing.

Using these criteria, we were able to determine the 21 blackjack sites we feel are the best for real money players on the internet today.

Story continues

The Best Online Blackjack Sites for Real Money Reviewed

1. Ignition Casino Best Welcome Bonus

Pros

Outstanding bonuses and loyalty program

Live dealer games available

Huge game selection

Several blackjack varieties on hand

Works on a variety of platforms

Cons

Ignition Casino really lives up to its name, as it's as close as you can get to a real-life casino experience from the comfort of your own home. They even have live dealer blackjack, where you can watch actual human dealers run your game.

You have a ton of table games to choose from, as well as a variety of real money blackjack games. These include classic, European, single deck, and more.

Ignition makes it easy to play, as they're available on Mac, Windows, iOS, and Android platforms.

They love to give away free money, too, as they offer a variety of bonuses and have a way above-average loyalty program. You can play for longer here than just about any other site.

It's surprising, then, that they don't have any e-wallet deposit or withdrawal options. This isn't a deal-breaker by any means, but it is annoying.

Go to: Ignition Casino

2. Red Dog Casino Best for Free Games

Pros

Great mix of free and real-money games

8 varieties of blackjack to choose from

Interface is intuitive and easy to use

Designed to be played on mobile devices

Cons

Red Dog Casino has a wonderful mix of free and real-money games, so you can make a bundle or just have some fun, depending on your mood.

There are 8 different blackjack games to choose from, including Perfect Pairs and Super 21. You can have a ton of fun with each of them, and the variety keeps things fresh.

If you're a beginner or you don't understand how to play one of the games, you can always play for free using their practice mode. It's a great way to learn the rules and it comes in handy, too, as their instructions aren't much help.

The interface is a bit old-fashioned and clunky, so don't expect to be blown away. However, it's also simple and intuitive, so it's unlikely you'll lose your shirt due to a misclick.

The games are designed to be played on mobile devices, and it's there that they look the best.

You can download their client or play it in your browser if you like, but the experience won't match up to the one you'll find on your phone or tablet.

Go to: Red Dog Casino

3. Super Slots Best Live Dealer Blackjack

Pros

Cons

Super Slots is a newer entry in the online casino game, but they've quickly made a name for themselves with their big bonuses and crypto-friendly deposit options.

As you might expect given the name, slot machines are the main attraction here, but their blackjack selection is good as well.

They have two weekly tournaments that draw a lot of attention, with the top 50 players enjoying the thrill of prize money.

Their welcome bonus is extremely attractive, as you can get a 300% match up to $2,000 and you can use it for your first three deposits. Of course, you'll have to work to cash in that $6k, as you may have as much as a 60x rollover.

They also offer multiple reload bonuses every week, so if you find yourself running out of chips, you can top off quickly.

You don't have much time to clear those rollovers, though, as many have 30-day requirements. Oh well guess you'll just have to play more blackjack!

Go to: Super Slots Casino

4. Intertops Casino - Best Loyalty Bonuses

Pros

Cons

No live dealer games

No deposit bonus

If you don't want to switch online casinos all the time to claim these welcome bonuses, then Intertops Casino is worth a look. They have the most generous loyalty bonuses which can keep you going for years.

Besides outstanding loyalty promotions, they have a huge variety of games, which is great as you can play for days in a row if you'd like and never get bored.

These include slots, blackjack, bingo, roulette, and many others. The only drawback here is that they don't have live dealer games. However, they make up with several fun table game variations like Zappit Blackjack.

As they recently updated their mobile app, it's very pleasing for an eye to hang out there for hours. Navigation and all the settings are very straightforward and intuitive.

Go to: Intertops Casino

5. Wild Casino Best Variety of Games

Pros

Cons

Let's get something out in the open right off the bat: Wild Casino isn't a great casino. If you're looking to play online slots, poker, or any number of other casino games, go to one of the other gambling sites out there.

If you're just interested in blackjack, though, it's an excellent option.

They have quite a few different types to play, including multi-hand and single-deck. You can easily spend an entire afternoon or longer exploring the various possibilities.

The games play equally well on desktop or mobile, so you can have fun wherever you happen to be at the time.

They have a large crypto focus in their banking, which could be attractive to some players.

However, that focus can work to their detriment as well, as those currencies can take up to 2 days to credit to your account.

Once you finally get some cash on there, though, you can quickly make it grow due to their generous bonus structure. The rollovers are clearly broken down according to game type as well, making it easy to claim your free money.

Go to: Wild Casino

6. Las Atlantis Best for Unique Games

Pros

No deposit fees

Payouts processed quickly

Game interface is easy to use

Works equally well on mobile and desktop

Cons

Las Atlantis is a fantastic overall casino, and if you're more concerned about things like ease of banking and ability to play other games, it's worth overlooking the fact that their blackjack selection is only pretty good.

They have 8 varieties of blackjack to choose from, so there's enough that you won't get bored, but not as many as some other casinos offer.

While the variety may not blow you out of the water, the games themselves are well-run. They're easy to understand and navigate, and you can play them just as easily on your phone as on your computer.

Everything else is top-notch, however. They don't charge deposit fees, and you can get your money off the site very quickly as soon as a couple of days or less in many cases.

They have some attractive deposit bonuses, but the best ones are reserved for slots, so you'll have to settle for scraps as a mere blackjack player.

Go to: Las Atlantis Casino

7. Slots.lv Best Mobile Gaming Experience

Pros

Cons

If you care how your games look, the Slots.lv is the place you want to be. They have the most attractive interface on the internet today, as well as plenty of ways to customize how your tables look.

That includes live dealer games, single- or double-deck games, and regular ol' blackjack. They also have fun variations like Zappit blackjack or Perfect Pairs.

It's not quite as attractive on mobile devices, largely due to the fact that they don't have a dedicated app. You'll have to play in your mobile browser instead.

They have a generous loyalty program with two different tiers, allowing you to make as much as $1,000 every month just for gambling. They'll even send you a gift on your birthday.

New players will find a great welcome bonus potentially worth $5,000, and the Bitcoin bonuses are exceptional as well.

If you do well at the tables, however, it could take some time to get your money off the site. Any withdrawals larger than $2,000 will be processed in monthly increments, so you could be waiting a while.

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Family’s horse shot, killed grazing on turnips | News | thedigitalcourier.com – The Daily Courier

Posted: at 6:28 pm

RUTHERFORDTON Investigators are trying to learn who killed a 21-year-old quarter horse as he grazed on turnips on a family farm in Rutherfordton.

A family member of Robert Hill, of Arrowood Road, discovered Blackjack lying dead on the property Monday morning. She observed the horse while driving along Arrowood Road, with the familys property on each side of the road. Blackjack had been shot in the head by what Rutherford County Sheriff Chris Francis said appears to be from a rifle.

Diamond Hill, Roberts daughter-in-law, said Blackjack had crossed Arrowood Road from the pasture toward a turnip patch but still on the familys property.

He was just eating turnips and minding his own business, Diamond said.

Blackjack was more than one of three horses on the Hills farm. He was born and raised there, then broke for riding.

He didnt have a mean bone in his body. He was as gentle as they come, Diamond said, adding Blackjack could be trusted to ride the familys younger children.

The Hills considered BlackJack a messenger from God. He was born on the same day Robert Hills infant grandson, William Bradley, underwent open heart surgery in Winston Salem. When they noticed Blackjack had a heart-shaped marking on his left side, they deemed it as a heavenly sign the child would survive the life-threatening operation. William Bradley, now 21, did survive and is among the family members grieving Blackjacks senseless death.

However, Bradley took a turn for the worse Tuesday and was admitted at Saint Lukes Hospital in Polk County. He was then transported to Mission Hospital in Asheville, according to Robert Hill.

Doctors believe Bradley has suffered a heart attack and currently has fluid around his heart, Robert added.

Diamond said the family has no enemies and knows no reason why someone would kill a harmless animal.

This was done by someone who has a sick, twisted mind, she said.

Francis said his investigators are following all possible leads, adding Blackjack was killed either late Sunday night or early Monday morning.

Robert said he has also shared newly learned information, but declined to specify.

There have been a lot of things going on in the neighborhood, Robert said, adding those activities are believed to be drug-related.

Francis worries the killing of Blackjack could trigger similar incidents.

I hope we dont have any copycat cases, Francis said.

Robert Hill said a state veterinarian responded to the crime scene and removed shrapnel from Blackjacks fatal wound.

Afterward, Blackjack was buried on the familys farm.

Robert Hill wants justice for Blackjack.

I can forgive them, but I want them punished for what they did, he said.

Anyone with information about the shooting death of Blackjack is asked to contact CRIMESTOPPERS 828-286-8477.

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5 Best Casinos To Visit & Play At On The Las Vegas Strip – VIVA GLAM MAGAZINE – vivaglammagazine.com

Posted: at 6:28 pm

Situated in Nevada in the United States, Las Vegas is a top world destination for tourists to visit. People from all around the world come to visit the Hoover Dam and Lake Tahoe. Tourists also come to experience helicopter rides from Las Vegas to the Grand Canyon too.

But one of the main reasons that people go to visit Las Vegas is because it is also known as The Gambling Capital Of The World. According to Statista, Nevada is the U.S state with the highest gross gaming revenue (GGR) of casinos in the U.S. In 2019, the state had a GGR of around $12 billion dollars.

The Las Vegas Strip is around 4.2m long and features a range of casinos, hotels, entertainment venues, shops, and restaurants. There is a wide variety of casinos that are on the iconic Strip for adults to play card games, slot games, and experience world-class nightlife.

Characterised by breathtaking dcor, landscaping, and numerous dining options, Wynn Las Vegas is a five-star awarding-winning resort in Nevada. Its opulent setting provides gamblers with over 189,000 sq ft of gaming space where they can play roulette, blackjack, other table games, and plenty of slot games. The establishment opened fifteen years ago and some of its fantastic attractions include the Lake of Dreams and the Wynn golf club.

As a high-end facility, Wynn Resort also has exclusive bars and lounges such as the Eastside Lounge, Lobby Bar, and the Tower Suite Bar. The Wynn Las Vegas hotel is also on the Cond Nast Traveller Gold List as one of the top hotels in the world.

Did You Know?

Together with its sister property Encore, the Wynn resort has 4,748 rooms which makes it the seventh largest hotel in the world.

Circus Circus is one of the older casinos in Las Vegas, having been established in 1968. The 52-year-old resort is not just a hotel and casino but also an adventurous circus. The Adventuredome is a 5-acre indoor amusement park which features a range of rides and attractions for visitors. Circus Circus is popular for its circus acts and carnival games and also has 123,928 sq ft of casino space.

Their casino has over forty table games available and some of the latest slot games too. Players can play virtual and live craps, three card poker, eight-deck blackjack, and much more. One of their legendary restaurants is their award-winning Steak House which offers a range of fabulous food.

Did You Know?

The Circus Circus establishment featured in a James Bond film. The hotels midway was featured in Diamonds Are Forever (1971) starring Sean Connery.

The Venetian was opened 21 years ago in 1999 and is themed on Venice, Italy. The hotel design takes inspiration from Italy and also has replicas of various landmarks including the Rialto Bridge, Palazzo Ducale, and the Lion of Venice Column. Much like other luxury establishments on the Strip, The Venetian has a range of restaurants, suites, swimming pools, and entertainment.

For gambling entertainment, the resort features two casinos for players to choose from: The Palazzo and The Venetian. They have a range of table games available for players to choose from including baccarat, roulette, and blackjack. Visitors can also check out their extensive selection of slot games on their two casino floors. The Venetian casino has around 1000 slots to play and The Palazzo has over 900.

Did You Know?

Inspired by the canals of venice, The Venitian has gondola rides for guests to experience. Guests can coast down an indoor or outdoor ride and experience unique views on an authentic venetian gondola trip.

The Bellagio resort in Las Vegas is world-famous and is famed for its luxury and elegance. With the stunning theme of Bellagio, Italy, it was opened 22 years ago in 1998. The Bellagio has also been a popular film setting for Hollywood films too. The classic Oceans Eleven (2001) used the Bellagio as a central setting. Just like other casinos on the Strip, the Bellagio casino has many table games like blackjack, craps, three card poker, and roulette. Before heading out to Vegas, players can brush up on their skills by playing live roulette online as well as other games, to get a taste of what playing at a real casino is like.

The Bellagio also has a Club Priv high limit lounge that is a private and elegant lounge for players. Similar to its other neighbouring resorts, the Bellagio also has many signature attractions. Its home to the aquatic Cirque du Soleil productionand has the signature Fountains of Bellagio. Enhanced by music and light, the fountains are a spectacle to behold and is not something to miss out on during a trip to Vegas.

Did You Know?

The Bellagio won the AAA Five Diamond Award fifteen years in a row! (2000 2015)

Built in 2009, The Aria is a resort and casino on Las Vegas Boulevard. The property consists of two high rise towers made from glass and steel; 61 and 51 stories high. The towers hold a AAA five diamond hotel that includes around 4,004 rooms and suites for guests. The towers also hold 16 restaurants, 10 bars and nightclubs, and the casino also has around 300,000 sq ft of gaming space. Their casino has a range of table games and slot games available and they also have a High Limit Lounge too.

The most impressive feature of the resort is how technology is integrated into the hotel design. Popular Mechanics had reportedly called it perhaps the most technologically advanced hotel ever built. It has rooms with smart technology that can adjust curtains, turn off unused lights and electronics, and can also regulate the temperature when a guest enters or leaves the room.

Did You Know?

The poker room at the Aria has hosted events for the World Poker Tour. In 2014, the hotel attracted around three and a half thousand entrants with their WPT500 event.

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A dying child, a mother’s love and the drug that changed medicine – Wired.co.uk

Posted: at 6:26 pm

Mila Makovec loved the great outdoors. Born in November 2010, she grew up on the outskirts of Boulder, Colorado and was skiing by the age of two. Before her third birthday Mila would go on long hikes, preferring to make her own way rather than be carried in a baby backpack. Shortly after her third birthday Mila started rock-climbing. This is not just a mom boasting about her child, says her mother, Julia Vitarello. She was really outgoing and advanced. But then, she adds, I started noticing things.

Before she turned four, Mila had started walking with an inturned foot. At the doctors surgery there was little alarm. Mila was diagnosed with tibial torsion an inward twisting of the shin bones that is relatively common among toddlers. But, for Julia, the diagnosis didnt add up. Over the coming months Mila became clumsier and clumsier. She would stumble and fall; her speech, previously eloquent and exuberant, became slow and staccato. In 2015, by the time Mila was five, doctors started using the word delay suggesting that she had been born with something that was hindering her development. That didnt make sense, says Julia. Mila was advanced.

The hunt for a diagnosis was arduous, encompassing more than 100 visits to doctors and therapists. Many doctors who assessed Mila commented on how developmentally advanced she was, despite her ever-growing list of symptoms. Then came the suggestion that maybe, just maybe, she had something incredibly rare. Julia started carrying around a piece of paper to note down any symptoms of a potential neurological condition. First it was stepping on toys and breaking them. All the toys in our house were broken. I would ask her, Mila, whats that in the corner? and she would say, Oh, its a butterfly. The next day I would ask again and she would look away like she didnt know. Suspecting that Mila might have a vision problem, Julia took her to an ophthalmologist and an optometrist, both of whom said she seemed fine. They also told me to chill out, Julia says.

One day in December 2016 Julia decided she needed some air. She went for a run, got bitten by two dogs and barely flinched. I didnt even realise Id been crying the whole time for Mila. Perceiving that she could no longer cope, she packed up a duffel bag, put Mila in the car and drove her to the Emergency Room. I heard the word seizure. I heard the word blind. She couldnt even stand, Julia says. Mila spent a week in hospital and received a myriad of tests. I saw her decline so quickly. Everything changed that week. Mila was diagnosed with Batten disease, an incredibly rare genetic disorder that gets progressively worse and is always fatal. I felt enormous relief, says Julia. And I also felt very guilty. Id been told I was crazy for three years, but there it was, in her genetic code.

Children with Batten disease have a problem with their lysosomes, enzyme-filled bags within cells that clear waste molecules. With defective lysosomes, this waste builds up and kills cells, causing brain damage and, by adolescence, death. Symptoms normally appear between the ages of five and ten years. Children suffer from vision problems and seizures. Their behaviour changes, they become clumsy, their spine starts to curve. The disease is fatal and there is no treatment or cure.

Milas doctors in Colorado sequenced the protein-coding part of her genome and found an error in one copy of a gene called CLN7, which codes for a protein that it is thought help molecules move across the membrane of the lysosome bags. To have Batten disease, both copies of CLN7 one from the mother and one from the father need to have mutated. Milas doctors could only find a defective gene from Milas father. To find the other mutation, Milas whole genome would need sequencing. At the time few labs in the world let alone just in the United States could do this, and even then it was prohibitively expensive and time-consuming. Mila was already six years old and her condition was worsening by the day.

But something else was at stake. Azlan, Milas younger brother, could also have been carrying the same fatal mutations. If he did, then he would soon start to show the same symptoms. I would look at my son, who was totally normal, just like Mila was, and the pain drove me to try and figure out what the mutation was, Julia says. Without knowing what both mutations were, there was no point checking out her son. To answer that question and confirm Milas diagnosis someone, somewhere, would need to find both mutations.

Faced with such challenges, many parents look to the frontiers of medicine. Julia founded a charity in her daughters name, Milas Miracle Foundation, and set herself a fundraising target of $4 million to put towards scientific research and treatment. Her end-goal was gene therapy. Gains made in this field are slow and expensive, but the need for breakthroughs is acute. Every year 7.9 million children are born worldwide with a serious birth defect of genetic, or partially genetic, origin. Thats six per cent of all births. An estimated 3.3 million of those children will die before they reach their fifth birthday. Treatments for such diseases are scarce, and cures are almost non-existent. To raise money for research, Julia realised she needed to improve awareness of Batten disease and other similar fatal genetic diseases. I learned that my tool was telling Milas story, she says. So I started telling it to everyone. I let the press into my house, I went on the news. I hated it I was so sad. But it was the only thing I could do.

In January 2017 Julia got a phone call from a doctor named Timothy Yu, a neurologist and neurogeneticist at Boston Childrens Hospital, whose work just happened to involve sequencing the genomes of people with autism. He had read about Mila on Facebook and wondered if he could help. Yu has run a lab at Boston Childrens Hospital since 2000 and has been carrying out whole-genome sequencing since 2010. We were one of the first to apply it to human disease, says Yu. Not only did he think he could help Mila and her family, but the work also aligned perfectly with his academic interests. This gave Yu both the will and, critically, the means to track down the missing mutation. My lab has been figuring out how to use high-throughput sequencing to diagnose disease and discover new causes of disease for a long time, he says. We know that there are a lot of cases out there of genetic conditions that go undiagnosed because traditional clinical testing doesnt cut it.

Yus task was to find a fragment of a needle hidden in the haystack of Milas genetic code. The doctors in Colorado had found the mutation from Milas father, meaning that Yu and his team could focus their efforts on finding the one inherited from Julia. At first we struck out, he recalls. All the standard ways of looking at the human genome sequence gave us nothing. After two days of failure, Yu and his team took a different approach: they started painstakingly combing through the raw genetic data by hand.

The human genome is three billion base pairs long. To analyse it manually, Yu and his team split it up into chunks that are about 100 letters long and started looking for the one tiny anomaly that would confirm Milas diagnosis. After days of searching, Yus team found something. A section within the CLN7 gene inherited from Milas mother didnt match up properly with the sequence of a normal CLN7 gene. Later analysis would reveal that a 2,000-letter stretch of DNA had jumped and landed there, breaking the gene. This extra chunk of DNA caused an error in Milas cells, disrupting their ability to make protein. This, in turn, had broken her bodys ability to clear out waste molecules. When he called Julia to deliver the news, Yu also had another crucial piece of information to share: while Mila had inherited the mutations from both her mother and father, Azlan had inherited neither. That was an enormous, enormous relief, says Julia. But also a huge reminder that Mila was going to die.

Yus initial promise to Julia was to find the mutation, and nothing more. But her jumping gene was unusual. It had essentially landed on a part of the gene between the important parts that encode the instructions for making the crucial cell-cleaning protein. Milas mutation was, it turned out, merely changing the way the instructions were assembled. Most mutations destroy the instructions. In Milas case, they were disrupted but still intact.

Just as the stars had aligned to connect Mila with Yu, so they aligned again when Yu and his team started to research possible treatments. In December 2016 only weeks before Yu first spoke to Julia the Food and Drug Administration (FDA), the US federal agency responsible for drug regulation, had approved a drug called spinraza. The drug is used to treat spinal muscular atrophy, a rare neuromuscular disorder that causes muscle weakness and is a leading genetic cause of death in infants, many of whom die before the age of two. The defect that spinraza targets is the assembly of a critical gene called SMN2. Spinraza reassembles this gene by removing the defect. This type of drug is called an antisense oligonucleotide (ASO) and it works by binding to defective RNA, hiding it and tricking cells into producing a normal protein. Yu had an idea: could he create a similar kind of genetic plaster to cover Milas fatal defect?

People were talking about it being curative, says Yu. I went into neurology because there is a huge unmet need. But, in reality, there are very few curative therapies in neurology. Spinraza changed that. When we looked at what spinraza did for those kids and we looked at the mutation that we found in our patient, it was the same story. Why couldnt we pull the same trick? It was a huge undertaking, made all the more challenging by the fact that Yu and his colleagues had never made a drug before. Were an academic lab. Im a clinician, Im not a drug developer. But when I looked at the basic science I couldnt see a reason why this wouldnt work.

Between April and October 2017, Yu and his team created a scientific proof of principle a new drug, targeted at one tiny mutation in one patient. If it worked, it would become the first single-patient drug ever created. But they faced one additional, potentially insurmountable hurdle: the FDA. We werent looking to commercialise a drug, says Yu. We werent looking to do what a pharma company would do. What we wanted to do was apply for permission to treat our patient under emergency access. This regulatory route allows doctors caring for individual patients to, for example, apply to use a drug that has been approved for use on another disease or a drug that is still in development and has not yet gone through clinical trials. If the need is dire and the application is successful then the treatment can be used. So we decided to choose that path, says Yu. Except that path had never been undertaken for a drug that hadnt undergone some professional development before.

Yu found himself at the frontier of not just medical science, but also regulation. The drug that he and his team had conceived had been developed in an academic lab, not by a pharmaceutical company. Not sure where to start, Yu naively called up an FDA hotline. Theres a 1800 number you can call. So I called them up and told them what I wanted to do. The FDA agreed to set up a conference call, which Yu ended up taking while on holiday. Sitting on the patio of a house that he and his family had rented for the weekend, Yu addressed the 15-member FDA panel. It was after this conference call that I realised, Oh gosh, I think it might be good to get some additional advisers on our side.

All the while Milas condition was worsening. One day in the summer of 2017, around six months after the diagnosis, Julia was lying in bed with her daughter. It was dark and Mila, as had become common, was struggling to get her words out. Her sentences were getting shorter and shorter. She was saying, Mommy, Mommy and she just kept getting stuck on Mommy. She could never get the rest of the sentence out. She was driving me nuts, Julia says. But then I realised I might never hear her say Mommy again. And that happened. I took a video that night in the dark. And I heard her say Mommy and it was just horrible. It was really horrible. By the autumn of 2017 Mila could no longer speak. All her food had to be blended to the consistency of mashed potato, and even then she choked all the time. She had also been fitted with a gastrostomy tube, in preparation for the day when she would no longer be able to eat or drink.

Back in Boston, Yu and his team were grappling with two challenges: how could they prove their drug was safe to use, and how could they manufacture it quickly enough? To tackle the first challenge, Yus laboratory tested the drug they had developed on skin and blood samples they had taken from Mila. This process, Yu recalls, was simple enough. But the logistical challenges proved more complex. The drug Yu had created, like spinraza, is known as an antisense oligonucleotide. For a laboratory-grade version of this drug, Yu would expect to pay as little as $10 for a small sample. For a higher quantity, maybe $300. But clinical-grade manufacturing is more costly and complex. Yu started calling around and was told that it would take six to nine months and cost hundreds of thousands of dollars to manufacture a clinical-grade version of his drug. The laboratory-grade version could be turned around in a week. The manufacturers he contacted were also only really geared up to produce huge quantities, perhaps as much as half a kilo. Yu only needed 2030 grams. Eventually they found a company willing to manufacture the drug in the right quantity and for the right price. The negotiations with the FDA were complex, but, remarkably, Yu continued to make good progress. But time was slipping away and so, in October 2017, manufacturing of the drug began, without FDA approval.

By this point Mila was having up to 30 seizures a day. She was smashing her legs and arms against tables. She was bruised. She was going down very quickly, says Julia. Milas disease, as is typical for Batten, was manifesting as a series of plateaus and cliffs for weeks Milas condition would stabilise, then she would rapidly deteriorate, before stabilising again. Each fall took another chunk of Mila with it. In January 2018, days after Julia and Mila had arrived in Boston hoping that FDA approval was imminent, the good news arrived. I was so overwhelmed, Julia says. Yu assembled his team and asked Julia and Mila to come into Boston Childrens Hospital. They were taken to an unremarkable back room, in which sat a refrigerator packed with vials of the new drug. The drug the first of its kind ever developed for just one patient now had a name: milasen. Before she received the first dose, Milas doctors anaesthetised her and carried out one final MRI scan of her brain and spine. Once the scans were done, she was wheeled into the room next door to receive her first dose of milasen, administered via a lumbar puncture.

For Julia and Yu it was the first moment of pause for almost a year. They sat in the MRI waiting room, leaning forward, their elbows on their knees, and they paused. Id been working day and night for the previous year it was probably one of the most intense professional periods that Id encountered, says Yu. In the weeks before, people had come up to me saying I was going to lose my licence for this. This is a very risky thing to do. But there was no other help coming. It was very, very clear that if we didnt do anything, she would have no quality of life and she would die within a few short years. I really came to peace with it, professionally and ethically and clinically. So we definitely did pause and take a deep breath and reflect on where we were.

The day after was blissfully boring. Mila had no adverse reaction to the drug. The first few doses also went without a snag and, over the next six months, Milas condition started not just to stabilise, but to improve. The number of seizures she had went down drastically and also became less severe. Where before they had been long and violent, now they were short and calm. Mila also began to hold up her own body again and started eating. She even started walking. With her mother standing behind her, their arms interlocked, Mila was able to take a few, stumbling steps. It was a pretty big deal, Julia says.

As the days turned to months, and the months to years, Milas disease started progressing again though more slowly than it had before. We know its not all a fairy-tale story, says Yu. We believe this drug is definitely helping, but there are areas in which this disease has progressed that are meaningful and impactful and sad. But I think it has provided her with an improved quality of life.

Julia agrees. Mila has always been a kid who loves imagery and storytelling and songs and has reacted well to nature. I try my best to engage her mind and body. Most days, a girl the same age as Mila comes round to read her stories. If she touches Milas hands, she feels a childs hands, Julia says. When Milas brother Azlan runs around the house and screams and shouts, Mila hears a childs voice. I believe, as her mother, that shes absolutely listening and paying attention.

Milas story is about so much more than simply one patient. Its extremely important to me that all the blood, sweat and tears that we put into milasen is not just for Mila, says Julia. Its opened the eyes of everyone. Its shown whats possible. The story of Mila represents the most profound realisation of personalised medicine yet. Her legacy, it is hoped, will be to make the path to treatment easier and less expensive for the next patient in desperate need. We can imagine a situation where the tools for drug development are good enough, and accessible enough, that a scientist can apply them to a single patient, says Yu. In this respect, Milas story is a story from the future. The pharmaceutical industry has already progressed from developing drugs to treat diabetes and heart disease illnesses that affect millions of people to develop treatments like spinraza, which target diseases found in only a few thousand patients. Milasen has shown that scientists have the tools at their disposal to develop treatments that can be applied to only one patient with a specific, targetable genetic mutation.

Theres a lot more work to do to be able to prove that the work we did with milasen, as a proof of principle, can be scaled, Yu says. Now, with an example of how it can work, he believes that healthcare is on the brink of a major change. Antisense oligonucleotides the genetic plasters behind the success of milasen and spinraza will likely be the first wave of this change. These are incredibly easy to make. You make them out of a machine thats about the size of a large, soft-serve ice-cream machine, says Yu. You type in the sequence, add in the ingredients and the drug is synthesised and comes out twenty-four hours later. This, says Yu, is a field that can become cheaper and more efficient in a relatively short space of time.

But, as he found while developing milasen, two major hurdles stand in the way: a scientific hurdle and a logistical one. Im a scientist, right? And weve still only done an N of one, Yu says, using the scientific term for a clinical trial with just one patient. If a graduate student comes up to me and shows me an experiment with an N of one, I tell them to go back and do it at least three more times. So conceptually, thats what we need to do. On the logistical side, Yu realises there are more complex challenges to overcome. In order to scale, this process has to be made simpler and less expensive, he says. More than 70 people were involved in the development of milasen. The cost of the development has never been disclosed, but spinraza, the treatment for spinal muscular atrophy that inspired Yu to develop milasen, costs $750,000 in its first year and $375,000 annually thereafter, placing it among the most expensive drugs in the world.

To be available to the hundreds of thousands of children born with fatal neurodegenerative diseases that can be targeted by antisense oligonucleotides, the price of treatment needs to come down, right down and fast. For that to happen, drug manufacturers will need to develop processes and business models that enable them to make lots of drugs in very small batches with quick turnaround times. Think going from spending nine months developing one drug to spending one month developing nine drugs. Regulators will also need to introduce new pathways for targeted, small-scale treatments. This will be a huge challenge for an industry that is used to regulating, manufacturing and monetising treatments that can be taken by hundreds of thousands or millions of patients, rather than simply a handful. Or one. Milasen shows that it can be done once, and so Julia and Yu are now focusing their efforts on showing it can be done time and time again.

In the future, the mutations that cause rare, often-fatal diseases could be targeted with precision medicines just like milasen. As whole-genome sequencing costs come down, such checks will become more routine giving physicians access to all the data they need to make an early and accurate diagnosis. Yu sees a future where parents of children with potentially fatal genetic mutations are immediately connected to experts who can explore the feasibility of making a drug and start the process in days, not months.

Parents could even be screened before they try for a child, to find out if they have mutations that could cause a fatal or life-limiting disease. They can know that they have a one-in-four chance of having a child with this disease, says Yu. The parents would then receive counselling to help them make the best decision. A foetus with an incurable, fatal genetic mutation could be aborted. Or, if in utero procedures could correct the genetic fault, treatment could be carried out at the earliest opportunity to give the child the best chance of a long, healthy life. The potential to eradicate some fatal genetic diseases before they even exist is one of the great promises of precision medicine. The diagnostic portion is ready to implement right now, says Yu. We just need the political will and the money to do it.

Julia compares the situation she faced when Mila was diagnosed with Batten to being handed an empty toolbox. Now, that box contains one truly remarkable tool. If and its a big if another child has Batten caused by the exact same genetic mutation as Mila, then there is a fridge in Boston that contains a lifetimes worth of treatment. And if that child is diagnosed sooner than Mila, then theres a chance they could press Pause on the disease and slow its progress earlier perhaps before that child even displays any symptoms. As a clinician and as a human, I think about that all the time, says Yu. What if we could have gotten to Mila sooner? What if wed been able to make this diagnosis in Mila at age four? We only met her at age six. Batten is a disease that gains momentum cells in the brain start dying, symptoms compile and accelerate. Coupling this kind of approach with earlier diagnosis is just so critical, says Yu.

No one wants to hear the story of a dying child, says Julia. But when its told in the light of hope, people want to listen.

Mila Makovec passed away on February 11, 2021.

James Temperton is WIRED's digital editor. He tweets from @jtemperton

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Global Cell and Gene Therapy Drug Delivery Devices Market 2020-2030: Focus on Product Type, Commercialized Drug Delivery Devices, and Competitive…

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DUBLIN--(BUSINESS WIRE)--The "Global Cell and Gene Therapy Drug Delivery Devices Market: Focus on Product Type, Commercialized Drug Delivery Devices, Country Data (16 Countries), and Competitive Landscape - Analysis and Forecast, 2020-2030" report has been added to ResearchAndMarkets.com's offering.

The global cell and gene therapy drug delivery devices market was valued at $55.75 thousand in 2019, and is expected to reach $375.13 thousand by 2030, registering a CAGR of 16.61% during the forecast.

Cell and gene therapy drug delivery industry is a transformative industry whose full potential is only just beginning to emerge. Cell and gene therapy involves the extraction of cells, protein, or genetic material (DNA) from the donor, and altering them to provide highly personalized therapy. Cell and gene therapies may offer longer-lasting effects than traditional medicines.

One of the significant drugs of the cell and gene therapy industry is CAR-T cell-based medicines, which include both cell therapy and gene therapy. Various market players are actively investing in the research and development of the cell and gene therapy industry. The players are offering improved and new products, which meet the critical needs of patients.

The growth is attributed to major drivers in this market such as the increasing prevalence of cancer and chronic diseases, increased funding in the cell and gene therapy market, rising need to develop novel treatment options for rare diseases, and rising biopharmaceutical R&D expenditure, and rising number of the FDA approvals of cell and gene therapies & clinical trials. The market is expected to grow at a significant growth rate due to various potential opportunities of growth that lie within its domain, which include drug approvals and strong pipeline of cell and gene therapies.

Various new cell and gene-based therapy approaches use biological engineering to improve the immune system's capacity to fight disease while sparing healthy tissues in the body. For instance, there are antibody-based therapies that can make T-cells more effective by increasing their interactions with cancer cells. Other modifications, such as adding complexity to the CAR-T and cancer cell interaction, which can further sharpen T-cells' cancer-targeting ability by reducing damage to normal cells.

The increase in the geriatric population and an increasing number of cancer cases, and genetic disorders across the globe are expected to translate into significantly higher demand for cell and gene therapy drug delivery devices market.

Furthermore, the companies are investing huge amount in research and development of cell and gene therapies and associated drug delivery devices products. The clinical trial landscape of various genetic and chronic diseases has been on the rise in the recent years, this will fuel the cell and gene therapy drug delivery devices market in future.

Within the research report, the market is segmented based on product type, commercialized drugs, and region. Each of these segments covers the snapshot of the market over the projected years, the inclination of the market revenue, underlying patterns, and trends by using analytics on the primary and secondary data obtained.

Competitive Landscape

The exponential rise in the application of precision medicine on a global level has created a buzz among companies to invest in the development of novel cell and gene therapy drug delivery devices.

Due to the diverse product portfolio and intense market penetration, Novartis AG, Kite Pharma Inc., and Dendreon Pharmaceuticals LLC. have been the pioneers in this field and been the major competitors in this market.

The other major contributors of the market include companies such as Vericel Corporation, Amgen Inc., Bausch & Lomb Incorporated, Spark Therapeutics, Inc., and Becton, Dickinson and Company.

Based on region, North America holds the largest share of cell and gene therapy drug delivery devices market due to substantial investments made by biotechnology and pharmaceutical companies, improved healthcare infrastructure, rise in per capita income, early availability of approved therapies, and availability of state-of-the-art research laboratories and institutions in the region. Apart from this, Asia-Pacific region is anticipated to grow at the fastest CAGR during the forecast period.

Companies Mentioned

For more information about this report visit https://www.researchandmarkets.com/r/110jum

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