Daily Archives: March 11, 2021

Overview

Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. TMS is typically used when other depression treatments haven't been effective.

This treatment for depression involves delivering repetitive magnetic pulses, so it's called repetitive TMS or rTMS.

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In transcranial magnetic stimulation (TMS), an electromagnetic coil placed against the scalp creates a magnetic field that stimulates certain areas of the brain.

During an rTMS session, an electromagnetic coil is placed against your scalp near your forehead. The electromagnet painlessly delivers a magnetic pulse that stimulates nerve cells in the region of your brain involved in mood control and depression. It's thought to activate regions of the brain that have decreased activity in depression.

Though the biology of why rTMS works isn't completely understood, the stimulation appears to impact how the brain is working, which in turn seems to ease depression symptoms and improve mood.

There are different ways to perform the procedure, and techniques may change as experts learn more about the most effective ways to perform treatments.

Depression is a treatable condition, but for some people, standard treatments aren't effective. Repetitive TMS is typically used when standard treatments such as medications and talk therapy (psychotherapy) don't work.

Repetitive TMS is a noninvasive form of brain stimulation used for depression. Unlike vagus nerve stimulation or deep brain stimulation, rTMS does not require surgery or implantation of electrodes. And, unlike electroconvulsive therapy (ECT), rTMS doesn't cause seizures or require sedation with anesthesia.

Generally, rTMS is considered safe and well-tolerated. However, it can cause some side effects.

Side effects are generally mild to moderate and improve shortly after an individual session and decrease over time with additional sessions. They may include:

Your doctor can adjust the level of stimulation to reduce symptoms or may recommend that you take an over-the-counter pain medication before the procedure.

Serious side effects are rare. They may include:

More study is needed to determine whether rTMS may have any long-term side effects.

Before having rTMS, you may need a:

These evaluations help make sure that rTMS is safe and a good option for you.

Tell your doctor or mental health provider if:

Repetitive TMS isn't invasive, doesn't require anesthesia and can be performed on an outpatient basis. You don't need to arrange for someone to drive you home after treatment unless, for the first treatment, you prefer a driver until you get a sense of how you'll feel afterward.

Before considering treatment, check with your health insurance company to see whether rTMS is covered. Your policy may not cover it.

Repetitive TMS is usually done in a doctor's office or clinic. It requires a series of treatment sessions to be effective. Generally, sessions are carried out daily, five times a week for four to six weeks.

Before treatment begins, your doctor will need to identify the best place to put the magnets on your head and the best dose of magnetic energy for you. Your first appointment typically lasts about 60 minutes.

Most likely, during your first appointment:

Once the coil placement and dose are identified, you're ready to begin. Here's what to expect during each treatment:

You can return to your normal daily activities after your treatment. Typically, between treatments, you can expect to work and drive.

If rTMS works for you, your depression symptoms may improve or go away completely. Symptom relief may take a few weeks of treatment.

The effectiveness of rTMS may improve as researchers learn more about techniques, the number of stimulations required and the best sites on the brain to stimulate.

After completion of an rTMS treatment series, standard care for depression such as medication and psychotherapy may be recommended as ongoing treatment.

It's not yet known if maintenance rTMS sessions will benefit your depression. This involves continuing treatment when you are symptom-free with the hope that it will prevent the return of symptoms.

However, if your depression improves with rTMS, and then later you have another episode of symptoms, your rTMS treatment can be repeated. This is called re-induction. Some insurance companies will cover re-induction.

If your symptoms improve with rTMS, discuss ongoing or maintenance treatment options for your depression with your doctor.

Explore Mayo Clinic studies of tests and procedures to help prevent, detect, treat or manage conditions.

Nov. 27, 2018

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Transcranial magnetic stimulation - Mayo Clinic

Depression is the leading cause of disability in the United States among people ages 15 to 44. While there are many effective treatments for depression, first-line approaches such as antidepressants and psychotherapy do not work for everyone. In fact, approximately two-thirds of people with depression dont get adequate relief from the first antidepressant they try. After two months of treatment, at least some symptoms will remain for these individuals, and each subsequent medication tried is actually less likely to help than the one prior.

What can people with depression do when they do not respond to first-line treatments? For several decades, electroconvulsive therapy (ECT or shock therapy) was the gold standard for treatment-resistant depression. In fact, ECT is still considered to be the most potent and effective treatment for this condition, and it continues to be used regularly across the country. For many people with depression, however, ECT can be too difficult to tolerate due to side effects on memory and cognition. For those individuals and the many others who have had an inadequate response to medications and therapy alone, there is a newer treatment option called transcranial magnetic stimulation (TMS).

Transcranial magnetic stimulation, or TMS, is a noninvasive form of brain stimulation. TMS devices operate completely outside of the body and affect central nervous system activity by applying powerful magnetic fields to specific areas of the brain that we know are involved in depression. TMS doesnt require anesthesia and it is generally exceptionally well tolerated as compared to the side effects often seen with medications and ECT. The most common side effect is headache during or after treatment. A rare but serious side effect is seizures, and TMS may not be appropriate for people at high risk such as those with epilepsy, a history of head injury, or other serious neurologic issues.

Approximately 50% to 60% of people with depression who have tried and failed to receive benefit from medications experience a clinically meaningful response with TMS. About one-third of these individuals experience a full remission, meaning that their symptoms go away completely. It is important to acknowledge that these results, while encouraging, are not permanent. Like most other treatments for mood disorders, there is a high recurrence rate. However, most TMS patients feel better for many months after treatment stops, with the average length of response being a little more than a year. Some will opt to come back for subsequent rounds of treatment. For individuals who do not respond to TMS, ECT may still be effective and is often worth considering.

TMS therapy is an intensive treatment option requiring sessions that occur five days a week for several weeks. Each session may last anywhere from 20 to 50 minutes, depending on the device and clinical protocol being used. When patients arrive, they may briefly check in with a technician or doctor and then begin the stimulation process. The technician will determine the ideal stimulation intensity and anatomical target by taking advantage of a landmark in the brain called the motor cortex. By first targeting this part of the brain, the team can determine where best to locate the stimulation coil as it relates to that individuals brain and how intensely it must fire in order to achieve adequate stimulation. Calculations are then applied to translate this data toward finding the dorsolateral prefrontal cortex, the brain target with the greatest evidence of clinical effectiveness and an area known to be involved in depression. Though one session may be enough to change the brains level of excitability, relief isnt usually noticeable until the third, fourth, fifth, or even sixth week of treatment.

TMS is being studied extensively across disorders and even disciplines with the hope that it will evolve into new treatments for neurological disorders, pain management, and physical rehabilitation in addition to psychiatry. There are currently large clinical trials looking at the effectiveness of TMS in conditions such as pediatric depression, bipolar disorder, obsessive-compulsive disorder, smoking cessation, and post-traumatic stress disorder. While promising avenues for research, TMS for these conditions is not yet approved and would be considered off-label.

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Transcranial magnetic stimulation (TMS): Hope for stubborn ...

Gebrder Weiss Goes Live with 3Gtms and CargoWise Integration

Gebrder Weiss Goes Live with 3Gtms and CargoWise Integration

SHELTON, Conn., March 10, 2021 (GLOBE NEWSWIRE) -- Gebrder Weiss has implemented the commercial integration between 3Gtms, 3Gs modern-day transportation management system (TMS), and CargoWise, a leading global logistics execution platform. The integration utilizes 3Gtms to manage the companys domestic freight needs and CargoWise for international forwarding operations.

The solution uses CargoWises integration layer to incorporate 3Gs powerful TMS, allowing for data integration not possible with any other domestic TMS. The integration provides a digital, streamlined process for managing the connectivity between CargoWises international freight forwarding core module and multiple domestic ground transportation providers in a highly optimized way.

The commercial integration between CargoWise and 3Gtms has allowed us to seamlessly manage international air and ocean along with domestic freight, said Kate Leatherbury, Director - Domestic Transportation Solutions, Gebrder Weiss. COVID-19 caused massive swings in freight volumes, including huge spikes in domestic movements. The CargoWise and 3Gtms integration allows Gebrder Weiss to handle these spikes without adding more staff while fulfilling the rapidly changing needs of our client base.

3Gs domestic TMS solution reduces costs and increases the speed and flexibility of Gebrder Weiss to grow and retain customers with optimized loads and increased automation for any TL, LTL, and parcel shipping needs.

This partnership is a credit to the commitment from the 3G and CargoWise development teams regarding production processes, said JP Wiggins, co-founder and vice president of logistics, 3G. Gebrder Weiss was a joint mutual customer of both CargoWise and 3G that had custom self-built integrations and was perfect for the commercial integration.

The CargoWise and 3Gtms integration was initially launched in Gebrder Weiss Atlanta branch and has since been implemented in all seven of the companys U.S. locations.

About Gebrder Weiss

Gebrder Weiss, a global freight forwarder with a core business of overland transport, air, and sea freight and logistics, is the world's oldest transport company with a history that dates back more than 500 years. The family-owned company employs more than 7,100 people worldwide and boasts 150 company-owned locations. The business established a presence in the United States in Chicago in 2017 and has since expanded its North American locations to include Atlanta, Boston, Dallas, Los Angeles, New York, San Francisco, Montreal, Toronto and Vancouver. Developing and changing with its customers' needs during its long history, Gebrder Weiss is also a pioneer in sustainable business practices having implemented myriad ecological, economic, and social initiatives. The company's voyage into North America, along with its continuous growth, illustrates the need for highly experienced providers of global solutions through an international network of supply chain experts. Customized solutions with a single point of contact provide customers with an exceptional service experience focused on reliable and economical solutions.

About CargoWise

CargoWise is a single source, deeply integrated, and truly global platform designed to meet the diverse needs of the logistics industry.

A highly flexible and feature-rich system, CargoWise delivers powerful productivity, extensive functionality, comprehensive integration and deep international compliance capabilities.

CargoWise is a cloud-based software platform that enables customers to execute highly complex logistics transactions and manage their operations on one database across multiple users, functions, offices, and countries. Translated into 30 languages and operating across currencies, CargoWise offers truly global capabilities for a global industry.

CargoWise grows with your company, streamlining your processes, integrating your business with your customers and partners, and increasing your efficiency, visibility, and profitability at any size.

For more information, visit http://www.cargowise.com

About 3G

3G is a leading provider of cloud-based end-to-end transportation management software (TMS) for omnichannel shippers, e-commerce companies, 3PLs, and freight brokers. Our solutions include 3Gtms, our multi-modal transportation planning, optimization, execution, and settlement system; and Pacejet, our advanced multi-carrier shipping software. For more information, visit3Gtms.com.

Media Contact

Sam Bush3G614 505 7290sbush@3gtms.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/ec1c2b3b-5a54-4fee-bf40-634f5df8398e

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Gebrder Weiss Goes Live with 3Gtms and CargoWise Integration for International and Domestic Transportation Management - GlobeNewswire

The world is moving at an unbelievable pace, and nowhere is that more apparent than in technology. As available technologies expand and become more advanced, the line between the physical and virtual worlds gets more narrow. The physical side of technological advancements includes computers, mobile devices and sensors, while the virtual side is the software running on those physical devices.

Within the supply chain, various stakeholders run a wide variety of software solutions. These technologies manage operations, keep track of assets, plan shipments, complete transactions, identify new business opportunities, communicate with employees, monitor compliance and handle maintenance needs. Each of these solutions, which may be provided by different technology providers, represents a node that collects data.

While back-office shipper, broker, third-party logistics (3PL) and carrier staff have long used computers to manage operations within a transportation management system (TMS) or warehouse management system (WMS), the U.S. electronic logging device (ELD) mandate and upcoming Canadian ELD mandate have rapidly accelerated the use of physical technology in each truck thats on the road in the form of in-cab e-logging devices. The newfound ubiquity of technology within the trucking sector has unlocked huge potential for the industry to create a network of nodes that communicate with each other.

By connecting all of those nodes together as a single network rather than individual fragments, new opportunities for collaboration can be found within the supply chain opportunities that simultaneously improve uptime, create efficiencies and reduce costs.

There are many pieces of a shipments journey that must be managed correctly in order for it to get from shipments from origin to destination. Many solutions may be used along the way, including an enterprise resource planning (ERP) system, a procurement system, a TMS, WMS and more. A connected supply chain would bring the data from each of these solutions together into a single network platform, regardless of which provider developed each specific tech solution.

Additionally, each role within the supply chain, whether its a shipper, carrier, broker or 3PL, has a different set of goals and needs. These are similar enough that increased visibility into each others data would give all stakeholders the ability to collaborate more closely and create efficiencies.

In the past, tech solutions in the supply chain were built to stand alone or only integrate with the other solutions within that companys portfolio. This led to a very painful and expensive rip-and-replace mindset around hardware and software solutions that has ultimately become unbearable for the industry.

The good news is that pain helped create a new way of doing business, and those painful days are gone. What transportation and logistics companies need now is the ability to integrate all of the discrete solutions within their own operations, as well as to third parties, in order to keep shipments moving quickly and effectively.

Allowing users to access a more modular network of apps is what will eventually create a best-in-breed system that enables more transparent data visibility and collaboration between parties. It will bring down the cost of doing business while increasing efficiencies and enabling even more advanced analytics and insights.

The supply chain industry is only now beginning to scratch the surface of what is possible when advanced technologies are leveraged in tandem. As the world continues moving and changing, two of the most exciting new areas in technology are cryptocurrency and blockchain. These two technologies are very buzzworthy and often misunderstood, but the potential that both hold is amazing.

Blockchain is a new way to securely validate transactions and cryptocurrency is an alternate mode of payment for services. Both of these new forms of technology often go hand-in-hand as modular solutions, just like the connected supply chain. In fact, the network of connected nodes could be driven by blockchain, encrypting and validating every transaction that occurs throughout a shipments journey, and payments could be made using cryptocurrency.

The retail and warehousing sectors are already being transformed, but will continue to see massive changes in the near term as companies become more intelligent about what theyre stocking and how they stock it. Every day we move closer to a future where retail stores are more like showrooms, with customers ordering products in store for next-day or even same day home delivery. This future is enabled by increasingly advanced and connected technology.

While there is still work to be done over the coming years to bring these ideas into everyday use, these are no longer crazy, futuristic concepts. Instead, these futuristic technologies are currently being built, which means that the rest of the supply chain will need to catch up in order to be ready to take full advantage of the value they provide.

The supply chain fuels the world, so how are we fueling the supply chain? Preparing for a more collaborative, modular environment is the first step to enabling the supply chain of the future.

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Connecting the Supply Chain One TMS at a Time - Supply and Demand Chain Executive

DALLAS, March 11, 2021 (GLOBE NEWSWIRE) -- Axele, LLC, a Transportation Management System (TMS) company, announces hosting a webinar with the Truckload Carriers Association (TCA), on "How Small and Midsize Carriers Can Harness the Power of Data." The free webinar will be at 1:00 PM ET, March 18, 2021.

Technology provides larger carriers with lots of data, but owner-operators and small-to-medium-sized carriers get left out of the loop," says Ryan Camacho, Director of Strategy & Business Development, Axele. This free webinar explains how to extract meaningful data without spending a fortune and use data to improve the bottom line.

Join TCA, DAT Principal Industry Analyst Dean Croke, ATBS President and CEO Todd Amen, and Axele Director of Strategy & Business Development Ryan Camacho at 1 PM ET on Thursday, March 18, as they discuss:

To register for the webinar, visit https://www.truckload.org/events/how-small-and-midsized-carriers-can-harness-the-power-of-data/.

Axele provides an intelligent transportation management system (TMS) for truckload carriers. It helps them find better loads, automate day-to-day business processes, and grow business with increased profits. Axele TMS integrates with load boards, ELDs, Market Rates, Maps, Accounting Systems, and more. The TMS automates customer invoicing, driver settlement, and document management. It uses hours of service (HoS), driver preferences, and load profitability to reduce deadheads and fill schedules with more profitable loads.

About Axele

Axele offers transportation management system (TMS) cloud software for truckload carriers. The company leverages decades of experience and insights into optimization and automation technology. Launched by Optym in 2020, Axele is the industry's first intelligent, connected solution, built specifically for small to mid-size truckload carriers. Axele serves for-hire truckload operators and private fleets who haul general freight, dry van, flatbed, and refrigerated loads. The Axele TMS integrates with load boards, ELDs, market rates, maps, and accounting systems, to enable an owner-operator or carrier to find better loads, increase profits, and grow their business. For more information about Axele, go to http://www.axele.com.

Media Contact for Axele:Becky BoydMediaFirst PR(770) 642-2080 x 214Cell (404) 421-8497Becky@MediaFirst.Net

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Axele Webinar: How Small and Midsized Carriers Can Harness the Power of Data - GlobeNewswire

The global Transcranial Magnetic Stimulators (TMS) market size is expected to gain market growth in the forecast period of 2020 to 2025, with a CAGR of 9.3% in the forecast period of 2020 to 2025 and will expected to reach USD 126.7 million by 2025, from USD 89 million in 2019.

The Years Considered for The Study in The Transcranial Magnetic Stimulators (TMS) Market Report Are as Follows:

The Apex Market Research update on Global Transcranial Magnetic Stimulators (TMS) Market 2021-2026 Interesting fact and figures (CAGR, Global Size, Shares and Revenue with Business Growth Support and Market Value and Volume with Supply Demand Scenario and Pipeline Projects)

As far as competitive scale is concerned, the report also includes information on Billiard Tables market growth tactics undertaken by industry players such as M&A and expansion strategies. This report looks at the key factors influencing the Billiard Tables market growth, opportunities, challenges, and risks faced by key players and the market. By listing a very comprehensive summary of the Billiard Tables market size, this report also includes the total valuation that the Billiard Tables industry currently has, a brief segmentation of this market, and the growth opportunities of the Billiard Tables market from this industry in addition to its geographical extension.

Report begins with the overview of The Industry Chain Structure and describe the industry environment, then analyze the market size and forecast of Billiard Tables by product, region and application, moreover, this report presents the competition situation of the market between suppliers and the company profile, in addition, the analysis of market prices and the characteristics of the value chain are covered in this report.

Get the Sample copy of Transcranial Magnetic Stimulators (TMS) Market Research and Market Analysis @ https://www.apexmarketsresearch.com/report/transcranial-magnetic-stimulators-tms-market-943686/#sample

Covid-19 Impact:

Global financial market is in crises as Covid-19 spreads all over the world. The coronavirus epidemic is relevant and has extensive effects for the market. Many industries are facing a rising number of critical concerns such as supply chain disruption, increasing risk of recession, and a possible reduction in consumer spending. The possible Transcranial Magnetic Stimulators (TMS) market loss expected revenue, development scope with the help of new technologies are covered in a detailed manner.

Scope of the report:

Get Free Exclusive Sample PDF along with few company profiles:

This report also provide In-depth studies of following point.

By Product Types segment on main Transcranial Magnetic Stimulators (TMS) market:

By Application this report listed main Transcranial Magnetic Stimulators (TMS) market:

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Regional coverage (regional production, demand and forecast by countries, etc.):

North America (US, Canada, Mexico)

Europe (Germany, UK, France, Italy, Russia, Spain, etc.)

Asia-Pacific (China, India, Japan, Southeast Asia, etc.)

South America (Brazil, Argentina, etc.)

Middle East and Africa (Saudi Arabia, South Africa, etc.)

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The Billiard Tables market report shows growth trends and future opportunities at the geographical level. This report helps to understand the global Billiard Tables market trends in the industry and to develop schemes to be executed in the future. Additionally, the Billiard Tables market research report summarizes some of the leading companies in the Billiard Tables industry. Mention your strategic initiatives and provide an overview of your business.

The study on the global Billiard Tables market includes qualitative factors such as drivers, restraints, and opportunities. The study covers the qualitative and quantitative analysis of the market segmented by type, technology and vertical. Additionally, the study provides similar information for key geographies.

The Transcranial Magnetic Stimulators (TMS) Analysis Report offers a comprehensive substantial study of the Transcranial Magnetic Stimulators (TMS) market, the key tactics followed by the major Transcranial Magnetic Stimulators (TMS) industry players and the segments they are approaching. The previous and current Billiard Tables industry forecast analysis in terms of volume and value along with the research conclusions is a decisive part of the Billiard Tables market analysis report.

Billiard tables Marketing strategies and analysis are done as follows:

The report clarifies an essence of the proven and innovative strategies undertaken by potential stakeholders regarding the commercialization of the product.

Sales channels are chosen (including direct and indirect marketing) by the companies briefly listed in the Billiard Tables market report.

The distributors of these products and the essence of the first-rate customers for them are also included in the study.

The report includes the fundamental driving forces influencing the marketing landscape of the Billiard Tables market and their impact on the revenue scale of this business sphere.

The growing demand for products from key geographies as well as critical applications and potential business areas are also included in the Billiard Tables market report.

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Key Questions Given in Global Billiard Tables Market Report Include:

1. What will the market size and growth rate be in 2026 with the effect of COVID-19 on the global Billiard Tables market?

2. What are the major market trends impacting the growth of the global Transcranial Magnetic Stimulators (TMS) market with COVID-19 impact analysis?

3. Who are the key players working in the world market?

4. What are the important factors driving the worldwide Billiard Tables market?

5. What are the challenges for market growth in the global Billiard Tables market?

6. What are the opportunities and threats faced by suppliers in the international market?

7. What are the main effects of the five force analysis of the global Billiard Tables market?

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Transcranial Magnetic Stimulators (TMS) Market worth $126.7 million by 2026 and projected to rise at CAGR 9.3% from 2020 to 2030 Exclusive Report by...

The Transportation Management Systems (TMS) market business study is a collection of robust market insights crucial to growth such as enterprise profiles, economic repute, latest traits, mergers and acquisitions, and the SWOT analysis and other aspects. The Transportation Management Systems (TMS) market report also details a comprehensive forecast over the coming years and also details various aspects that are essential in planning a competitive strategy for the forecast.

Decisive Players in the report are: Webfleet Solutions, Masternaut, Microlise, Transics, Trimble Inc

Grab your Sample PDF here @https://www.reportsintellect.com/sample-request/1894706?ata

Description:

The report studies the Transportation Management Systems (TMS) market landscape on various aspects and dynamics and gives the client a complete guide map to create and implement various business tactics and business plans. The report has been compiled by gathering data through primary and secondary sources which is triangulated by several different verticals and segments to give a definitive overview of the Transportation Management Systems (TMS) market.

By types:

Cloud Based TMSServer Based TMS

By Applications:

Logistics CompanyManufacturerE-commerce Company

Major Geographical Regions covered are:

North America Country (United States, Canada)South AmericaAsia Country (China, Japan, India, Korea)Europe Country (Germany, UK, France, Italy)Other Country (Middle East, Africa, GCC)

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Additional Highlights:

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Transportation Management Systems (TMS) Market aspects that require the complete knowledge by: Webfleet Solutions, Masternaut, Microlise, Transics,...

Today, the Japanese carmaker is one of the biggest player in the automotive industry, and this achievement would not have been possible without the companys success in the United States.

It all started in the early fifties when Toyota executives began exploring an expansion of the passenger car business outside Japan. They set their sights on Europe and the U.S. markets, but the latters immense potential was far more appealing.

The companys preliminary research revealed that many returning members of the U.S. Army were moving to the suburbs and starting families, creating a demand for smaller, second cars.

Toyota continued to pay close attention in the following years, discovering that compact cars sales were almost doubling year after year. European manufacturers built the vast majority of those, which indicated that Americans were embracing foreign cars, so the market potential became unquestionable.

The car looked much like the Simca Vedette that had debuted a year earlier in France, but it had rear "suicide" doors, a feature previously used on the AA, Toyotas first car. Like its predecessor, the small four-door sedan was powered by the reliable 60-hp, 1.5-liter inline-four R engine.

It employed a suspension system that utilized independent double wishbones and coil springs in the front and triple semi-oval leaf springs at the rear. Since Japans road network was in bad shape at the time, the Crowns system made it extremely popular and Toyota executives hoped this popularity would translate to the U.S. market.

On August 25, 1958, two left-hand-drive Toyopet Crowns arrived on American shores, docking in California. General Electric-sourced sealed beam headlights and other safety features were fitted to the cars after their arrival to comply with local laws.

Newly appointed TMS ales administrator James McGraw stated that the Crown was underpowered, overpriced and it wont sell. Unfortunately, he was right; the car was purposely built for Japans rough road network but struggled on Americas smooth, free-flowing roads. It took an eternity to reach 60 mph (96 kph), and when it did, it shook so badly that drivers found it almost impossible to see out the rear-view mirror.

Moreover, the Toyopet moniker used by Toyota since 1947 as a result of a naming contest for the SA could not be taken seriously in the U.S. since it contained the nouns toy and pet. Coupled with its small size, many Americans jokingly called it a Japanese motorized stroller.

By the end of the year, Toyota managed to sell 287 Crowns, and in 1959, sales more than tripled to 967 units. For 1960, Toyota added a wagon body style and a larger 79-hp 3R engine, but sales fell to 659 units.

The sales continued to drop, and since TMA accumulated $1.42 million in losses, Toyota decided to stop all Crown exports to the U.S., focusing its efforts on the rugged Land Cruiser instead.

Although it wasnt as popular as anticipated in the U.S., the Toyopet Crown paved the way for many highly successful sedans like the Corona, Camry, Corolla, or Avalon.

The Crown never returned to the American market, but it carries on in Japan, where it is extremely popular. Now in its 14th generation, it holds the title for the longest-running Toyota passenger-car nameplate.

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The Forgotten Story of the First Toyota Sold in the U.S., the Toyopet Crown - autoevolution

CRESSKILL, N.J., March 11, 2021 (GLOBE NEWSWIRE) -- BrainsWay Ltd. (NASDAQ & TASE: BWAY) (BrainsWay or the Company), a global leader in the advanced noninvasive treatment of brain disorders, today announced that it will report its fourth quarter and full year 2020 financial results as well as operational highlights after the close of the financial markets on Wednesday, March 24, 2021. The Company will host a conference call and webcast on Thursday, March 25, 2021 at 8:30 AM Eastern Time to discuss the results and provide an update on business operations.

Conference Call Dial-In & Webcast Information:

The conference call will be broadcast live and will be available for replay for 30 days on the Companys website, https://investors.brainsway.com/events-and-presentations/event-calendar. Please access the Companys website at least 10 minutes ahead of the conference call to register.

About BrainsWayBrainsWay is a commercial stage medical device company focused on the development and sale of non-invasive neurostimulation products using the Companys proprietary Deep Transcranial Magnetic Stimulation (Deep TMS) platform technology. The Company received marketing authorization from the U.S. Food and Drug Administration (FDA) for its products for a variety of patient populations, including in 2013 for patients with major depressive disorder (MDD), in 2018 for patients with obsessive-compulsive disorder (OCD), and in 2020 for patients with smoking addiction. Additional clinical trials of Deep TMS in various psychiatric, neurological, and addiction disorders are underway. To learn more, please visit http://www.brainsway.com

Contacts: BrainsWay:Hadar LevySVP and General Manager[emailprotected]

Investors:Bob YedidLifeSci Advisors646-597-6989[emailprotected]

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BrainsWay to Report Fourth Quarter and Full Year 2020 Financial Results on March 25, 2021 - GuruFocus.com

XTM CEO Bob Willans joins SlatorPod to discuss the journey of the company he co-founded back in 2002. Bob talks about growing XTM with little outside funding to become a USD 11m SaaS company in 2021.

He tells us about XTMs decision and search to bring on financial backers in 2021, which culminated in XTMs majority sale to US-based investment firm K1 Investment Management in January 2021.

Bob shares his views on the TMS funding and investment boom in 2020, which he says had little to do with Covid (for the record), and unpacks the landmark shifts in translation management technology over the past two decades from the advent of the cloud to the integration of neural machine translation (NMT) and AI more broadly.

Bob also talks about milestone developments in XTMs product, including totally rewriting their translation editor at one stage, and discusses how the company balances out feature requests and customization for enterprise clients against general product enhancements.

First up, Florian and Esther run through the weeks language industry news, kicking off with some key stats from the Slator 2021 Language Service Provider Index (LSPI), which features more than 175 companies on its launch in early March 2021.

The two also talk about the Language Industry Job Index (LIJI), which climbed nearly 10 points in March 2021 to match pre-Covid levels, while Florian discusses the underwhelming consumer reaction to the Apple Translate app.

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Florian: First, tell us a bit more about XTM, in a nutshell, origin story, trajectory, key client segments.

Bob: Andy Zydro and I set up XTM in 2002. We started out very small and took a while to ramp up. We quickly set up a development center based in Pozna, Poland and today we have still got over 150 people there. Our development testing, support, marketing, systems admin team are all based out of Pozna. Then we have the rest of our sales team and solution architects dotted around the world in North America, South America, Europe, and Japan. XTM is pure tech. We do not provide any services and we focus on the large enterprise marketplace. XTM is highly scalable. It has been built with the enterprise in mind and that is our target market. As a result, we find that we sell to some very big enterprises, and then they specify XTM for their supply chain, so the LSPs use XTM as well.

Florian: Before XTM, what was your background? What was your career before?

Bob: I started out in South America working for a textile company as a factory manager in my late 20s and that is a pretty good experience learning about cultures and learning about leadership. From there, I went to Chile and Brazil and came back and set up an Apple dealership. I went down the entrepreneurial route. I did very well in that for a while and also set up an internet service provider called Redneck. We were one of the first in the UK. We sold that business at the top of the Dot-com bubble in 2000.

I then worked for SDL for a few years on one of the early TMS projects called SDL Webflow. Then Andy and I are who I had known for many years, we started talking and he had been working for Xerox and also Ford of Europe and said, I have got this great idea about creating a TMS, a great engine. I said, okay, show it to me, so he explained the idea and then we decided to set up a business to basically write a web-based TMS based on XML from scratch. We have been working hard at it ever since.

Esther: You have come a long way then since setting up the company in 2002. Let us talk about you teaming up with the investment firm K1. It seems like this is the first time you are taking in or bringing in outside capital. Why now?

Bob: We had a couple of very early investors, LSPs who were keen to support us in our early days but this is the first real serious investment. Why now? We have taken the company from zero to a USD 10m turnover. We can see the whole marketplace is really hotting up. There has been a lot of M&A activity. The competition is becoming increasingly strong. We needed to project where we would be in the next five years. We are very ambitious in terms of growth, in terms of our product. We thought it was the right time to bring in some external expertise, bolster our existing management team.

We worked with EY for about two years on their fast growth platform and they helped us enormously in terms of preparing for the investment and getting just the KPIs that you need for a SaaS business. We learned a lot from that, in terms of, MRR, ARR, churn rate, customer lifetime value, all these kinds of things, which are important. Then we approached a number of different private equity firms. We chose K1 because they were able to add the most value to us. They have an operations team based in Los Angeles who have a wide range of expertise. K1 specialize in fast growth, SaaS, businesses, B2B and so their operations team have a huge amount of knowledge there that they can share with us to help us on our next level of growth.

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Esther: It sounds like quite a long process, potentially lots of things involved. How distracting was it to go through that process while running the business?

Bob: We tried not to distract the people doing the hard work, the developers and the salespeople and the solution architects and the support team. They were not that involved but for the senior management team, yes, absolutely, we had to, but it is part of the process of growing the business. For me, it was educational and interesting and it has prepared us for the next phase of our growth.

Florian: Why do you think now, especially 2020, was the year for TMS funding. Why now? Why 2019, 2020?

Bob: I do not think it has anything to do with Covid-19, to put it that way, but the whole translation business previously was very people-centric, very reliant on people. It is now becoming far more tech-centric so that in order to provide the service, you have got to have the right technology. As a result, the technology sector is growing rapidly. You have got NMT on one hand, you have got TMS on the other hand, you have got lots of other technologies coming in there. Where there is growth you get companies that are interested in investing, whether through acquisition or as a private equity firm or VC. There is a land grab going on at the moment, there is such fast growth that companies realize that they have to win clients as quickly as possible and to do that, you need the resources to be able to go out there and make an impact.

Esther: Expanding on that, how do you broadly think that the TMS landscape has evolved and changed over the past two decades? What are some of the key shifts?

Bob: Well, obviously when we first started out, the predominant TMSs we are not web-based and we set out right from day one to ensure XTM was going to be web-based so we wanted a self-provisioning SaaS model. We wanted XTM to be entirely web-based, not something that you have to download files and work offline but we wanted the functionality to be as good as, or better than anything else on the market. That has been a big step forward, obviously, other companies have subsequently come into that space and are doing very well.

Other areas where I have seen big changes are, obviously, machine translation which has come on enormously and the way we look at machine translation is as it is another tool for the translator. Obviously, that changes the work that the translator does. It is not just a question of seeing a translation memory match and accepting it or modifying a fuzzy match. Now it is more post-editing and I think that trend will continue. There will be more and more use of machine translation and AI for automating other things apart from the actual machine translation. We have done a huge amount of work on our proprietary technology that we call Inter-Language Vector Space. That is a cornerstone for our AI strategy so we are using that for alignment of parallel texts, we are using it for Bilingual terminology extraction and we have lots of plans for enhancing our translation environment with it as well, like predictive typing. That is all coming in and we are going to see more and more automation of the processes, so that project managers, for example, only have to get involved for exceptions rather than doing the routine stuff day in, day out.

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Esther: You mentioned a couple of things that XTM has been working on. Is there anything that you think looking back in the past four to five years has helped you or has served a particular purpose for clients?

Bob: Maybe four years ago we decided that what we call XTM Editor, our translation environment, which we had started building way back in the early 2000s had reached the end of life so we took the conscious decision to rewrite it from scratch, using the latest technology. We had a lot of input from translators to make sure we got the user experience right and so that took us a long time. It is very complex, with a lot of functionality but we have completed that, it is launched. We have built into what we call the visual mode that allows users to be able to visualize the source and target while they are translating in real-time.

We also have what we call CAR, computer-aided review, which is a translation environment or a review environment, which can be customized to the specific requirements. You can hide certain features because the problem with a fully functional workbench is that it gets very complex and you have got so much going on there that a reviewer thinks, I do not want to use this because it is too complicated. If you can strip it down and simplify it then it makes their whole work experience much better and we have found that is a very key thing for us.

The other thing that we have been working on very hard is our connectors and that is an ongoing project for us. We are building connectors to all the major content management systems, to repositories and it is not just a question of simple integration. We want to have a deep integration with lots of functionality where the user within the content management system can decide which content they want to send, how to send it, when to send it, track the content as it is going through the translations, set, for example, a workflow template within XTM. All from within the content management system and then obviously receive the translated content back automatically to the right place. In some cases, we can do the preview of the web page within XTM so that you can reduce the requirement to do a review cycle within the CMS.

Florian: On the connector side as a non-developer is it primarily a development problem or is it also a contractual problem? Where you need to go through all these AP servers and ask for their permission and then it is a two-year approval process or is it just for people that are not familiar with that process? How hard is it and where is the problem?

Bob: The problems are multiple. First of all, we are not experts in many of the CMSs out there so we need to find people who are experienced in them and we have done that for many of them. Then you have to start building the connector and whenever you are connecting to systems, there are always issues that you come across in terms of connectivity. They have to be sorted and then you have to bear in mind that the CMS will change versions, it will update, and that may break your connector so you have got to be one step ahead of that. Then of course, while we are selling a lot of XTM, only a percentage of those users will want a connecter so the volume of sales, relatively speaking of a connector, is not as great as XTM itself. That is another factor to bear in mind, but in terms of the improvement in functionality, it is enormous. It just cuts out so much routine work.

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Florian: For the cloud, when you started in 2002, there was no AWS. You had to basically just ditch the entire previous CAT component and recode it from scratch. On the cloud and just the infrastructure layer, do you reach a point where you are like, now there is AWS, let us just re-engineer the entire thing, or is it much more of a gradual transition?

Bob: We have the flexibility to deploy in a number of different ways. We have our multi-tenant cloud which is the self-provisioning one that people know, but we also have private cloud and that is a single-tenant solution for the larger enterprise. Then having done that, we can also do single-tenant private cloud on AWS as well. We use a combination. We also use a company called OVH who is one of Europes largest hosting companies. We use them for some solutions and AWS for others.

Florian: Tech only versus tech and services, let us go back to this age-old question. You are very firmly on the tech only side. Makes sense, makes a lot of conversations with investors also easier when you do not mix the two, but would you see any kind of scenario where it would make sense for a service provider to pursue a path of developing all of the technology in-house?

Bob: Transperfect has done that, havent they? They have done that very successfully. However, from our point of view and what we hear very loud and very clear from our customers is they would prefer to have a vendor-neutral technology so that they can then pick and choose which LSP they use and they can evaluate one against the other. The point is also that the enterprise controls its own assets. They are reducing or mitigating the risk to their assets, to their IP, because essentially the translation memory, all the content is their IP. We feel that a lot of companies want to control that very closely.

Esther: When you are thinking about what is important to clients, how do you prioritize things like feature requests, how do you balance out customization versus the general progress of the product? What takes precedence?

Bob: That is a pretty tough situation I am sure all tech providers face, we have. Our product manager Sarah has something called a product board where she gets all the feedback from our customers and we enter all these things on there. We have internal items that we want to do as well because things need to be updated or we have our own strategic direction that we want to go in. They will get put on the product board and then we have a meeting and we discuss what we can squeeze into because we do four releases a year and how we partition those items into each release.

Right now we are just about to release a new feature on our website based on the product board that will allow our key clients to go in and they will be able to see what we have released, what we have lined up for our next release, and they will be able to see or create requests for new items or vote on existing items that are already there. It is a more interactive way for customers to be able to see what we are doing and participate in the whole roadmap. You have to have a balance but at the same time, we like to stay responsive to our customers claims. We would love to be able to sell XTM and show it to the customer and they say, yeah, that is perfect, just what I wanted, thank you. Inevitably they say, yeah, that is great but we wanted to do XYZ and so we are responsive to that and try to help them achieve their goals.

Florian: The dynamics of where they are in the localization maturity level, can you speak a little bit to that? When some clients are far ahead, they have internal localization teams, they have a lot of it figured out as opposed to maybe, companies that are in an earlier stage. Is that a dynamic that is very important to you or it does not really matter in day to day?

Bob: I think there are two different types of customer. The mature customer probably has a TMS already, probably has a translation or localization department with a head. With their existing TMS, they may be coming up against some kind of limitation on that or some issue that they are looking at alternatives. For us, we love those kinds of customers because they know what they want and we can usually help them very well. On the more greenfield site where they do not have a TMS and they are probably less experienced in the whole process, that scenario we are increasingly targeting because we can see that it is a huge area that we have not really focused on a lot in the past, but certainly in our plans for the future. That is an area where we want to tackle more seriously.

Florian: You have some LSP clients, but as you mentioned, the focus really is on the enterprise. What is the dynamics there?

Bob: LSPs know what they want, they know their business so from that respect it is good. There is a bit of a challenge with LSPs in that they have to be able to process anything their customer asks them. Whereas an enterprise generally has a more consistent flow of translation tasks because they have a standard production workflow but having said that, XTM is a very flexible agile tool and so can easily be adapted to all the requirements that an LSP would need.

Esther: What is your view on how machine translation is shaping TMS development generally, and also, what do you perceive to be the natural limits of the integration between MT and TMS if there are any?

Bob: Machine translation is having a profound effect on the whole production cycle. There is far more machine translation going on now than there was last year or the year before so what is happening is that we need to adapt XTM or our TMS to be able to accommodate that. In order to do that we have recently, for example, added the ability to calculate the cost based on edit distance. What has a post editor actually had to do to bring the machine translation up to an acceptable standard? This is the edit distance, hence this is the cost. That change that we have had to make in order to accommodate it. How far will it go? It is a tough question. I am sure we have not reached the limits of machine translation yet. Some of the machine translation suppliers are now using translation memory in real-time to enhance their matches so there are lots of tricks that can still be done to improve it.

Florian: You said the ability to calculate costs based on the edit distance. Is that post or before? How does that work?

Bob: You would have to calculate the cost after the editing has been done, but, historically you would calculate the cost based on the number of words or some kind of algorithm based around the words. Now, when you are principally dealing with post-editing, how many words is not a relevant thing. You can work on time. You can base it on how long the post editor has had to spend on this task, or how many characters have had to be changed within this particular segment of text.

Florian: The industry has gone through this super challenging year. Generally, I think it was a positive year, given the circumstances. What is your outlook for the next three to five years? You have an outside partner now, you can ramp up investing in all kinds of areas so where are you going to deploy some of that capital? What are your priorities in terms of growth?

Bob: From our point of view we see the market continuing to grow. We see XTM in an ideal position, we have got a great product, great team, but at the moment we are just scratching the surface of many markets. We have a very wide cross-section of verticals from tech companies to construction, to retail, through life sciences to LSPs. We have a very wide cross-section of companies, but realistically, there are a hundred more out there where we have one market leader, we could be selling to a hundred. From our point of view, there is great potential. K1 recognized that XTM is a market leader in this respect and they will support us to capitalize on that potential.

Florian: When we talk to people offline, I am sensing a lot of buzz, I am sensing a lot of optimism generally, which is a bit different from a little bit of the MT panic of 2017, 2018.

Bob: There was definite panic thinking this is the end of the translation industry as we know it today. Whereas now you just have to accept that things evolve and MT is another tool and we have got to make the most use of it we can and just provide a better service. The volume of translation just goes up. The better tools you have, the more translation you can do.

Read more:

XTM CEO Bob Willans on Raising Capital and the Future of Translation Pricing - Slator