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Daily Archives: February 27, 2021
Senators Urge Biden Administration to Convene Coronavirus Task Force on Aviation Health and Safety Homeland Security Today – HSToday
Posted: February 27, 2021 at 3:28 am
Senator Edward J. Markey (D-Mass.),SenateCommerce Committee Ranking Member Roger Wicker (R-Miss.), andSenator Richard Blumenthal (D-Conn.)today sent a letter to the Departments of Transportation (DOT), Health and Human Services (HHS), and Homeland Security (DHS), urging these agencies to convene a joint task force on air travel during and after the coronavirus pandemic.This task force advised by aviation, security, and public health experts would develop recommended requirements, plans, and guidelines to address the health, safety, security, and logistical challenges for air travel moving forward.
We were pleased when the Biden administration recently called for interagency cooperation to develop national public health recommendations for domestic travel,write the lawmakers in their letter to DOT Secretary Pete Buttigieg, HHS Acting Secretary Norris Cochran, and DHS Secretary Alejandro Mayorkas.However, we believe that a more structured process remains necessary one that includes robust collaboration among government, industry, labor, and other experts, with the goals of solving the pressing problems created by the pandemic and charting a path forward as vaccinations accelerate and travel demand returns.
During the ongoing emergency, airlines and airports have largely had to develop their own rules for ensuring coronavirus-related health and safety. Unfortunately, a patchwork of rules simply cannot address the interconnected and widespread risks of a global pandemic. The letter calls for the federal government to lead and promulgate clear and consistent safety standards that apply across the entire aviation industry.
A copy of the letter can be foundHERE.The lawmakers letter specifically calls for a task force modeled after bipartisan legislation they recentlyreintroduced, and that passed the Senateunanimouslylast Congress. While the Senators will continue to fight for their legislation, the DOT, HHS, and DHS need not wait before acting on this initiative. These agencies can immediately convene a task force on aviation health and safety and begin the process of developing national solutions to protect the flying public.
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Guru Ravidass, his teachings are relevant even today: Prof Santosh K Singh – The Indian Express
Posted: at 3:26 am
This year for the first time in almost two decades, the Begumpura Express, a special train from Jalandhar to Varanasi, was cancelled due to the pandemic. This train has played a big role in Punjabs connection with Varanasi. Professor Santosh K Singh, a sociologist who has researched the caste dynamics of Punjab, and keenly followed the Ravidassia identity articulation through Jalandhar-based Dera Sachkhand Ballan over a decade talks to The indian Express about Punjab and its connection with Varanasi.
Guru Ravidass had propounded and advocated the concept of Begumpura or a city without sorrow (gam), where there will be no taxes and where there would be no discrimination and all would be located horizontally in the socio-economic landscape. Many of the legends and hagiographical accounts related to Guru Ravidas attest to his equalitarian philosophy, his non-combative sahajbhao or persuasive mode of preaching.
Train no. 12238, formerly Jammu-Tawi- Varanasi Express via Jalandhar, is now known as Begumpura Express.
On the occasion of Ravidass Jayanti every year, special reserved trains of Begumpura Express, carrying thousands of pilgrims begin their journey from Jalandhar Station to Varanasi, to commemorate the birth of Guru Ravidass.
The train engines front carries a full-size flex poster of Guru Ravidass and the compartments are all decked up with balloons and posters of the gurus of Dera Ballan. It has now become a tradition since early 2000.
The DJ system in the background, playing the songs of Dalit singers such as Ginni Mahi, Roop Lal Dhir and others, young Ravidassia frenetically dance outside the railway station as the decorated train starts for Varanasi.
The 15th century Bhakti poet Guru Ravidass was born in Varanasi, Uttar Pradesh, in a family belonging to a community that worked with leather and considered lowly and polluting in the caste-ridden social hierarchy. But through his sheer intellectual brilliance and by preaching the philosophy of inclusive coexistence, based on a casteless and classless society, he received widespread appreciation and reverence from people across all strata. Many from the then princely states, including Mirabai, became his disciples.
For over more than a decade the Dera of Ballan in Jalandhar has been singularly and actively in the forefront of developing the birth place of Guru Ravidass in Varanasi in Seer Goverdhanpur, close to the Banaras Hindu University campus, with generous financial support from its followers, a major chunk coming from the diaspora. Guru Ravidas Janamsthan in Varanasi in that sense over the years has emerged as a major pilgrimage centre for the Ravidassias of the region.
Guru Ravidass and his teachings are just as relevant even today. Guru Ravidass had a unique way of critiquing the discriminatory caste system and ritualism prevalent in the society. Guru Ravidas, preached without any irreverence to those who did not follow him.He continued to practice his traditional caste-profession throughout his life, despite accolades and the status of an enlightened soul, essentially to communicate a message that the work or labour is what takes the human beings closer to the almighty or Hari and there is no hierarchy of professions. When the Guru Granth Sahib, the holy book of the Sikhs, was being compiled, 40 shabads of Guru Ravidass were included in it, signifying the prevailing ethos of syncretism and religious co-existence.
Yes. One has to travel and be part of it to actually experience it. In UP, the local Ravidassia groups will assemble with bands and much fanfare to greet the Dera Mahant and the pilgrims. On these occasions, stations get filled with the thunderous chants of Jo Bole So Nirbhaya, Sat Guru Ravidas Maharaj Ki Jai, the salutation of the Ravidassia, meaning Be fearless, the disciple of Guru Ravidas. The salutation announces the communitys public presence and demonstrates its growing strength and aspirations.
Indelibility of caste as an institution is well documented. Punjab society too experienced this phenomenon where caste markers continued to stigmatise some as the lowly and polluting despite a vibrant and egalitarian culture of social existence propagated by Sikhism. The mushrooming of Dalit-Deras of all denominations and the phenomenon of separate Dalit gurdwaras and cremation grounds in the villages of Punjab represent that collapse of that collective dream of Begumpura, as Ravidas envisioned.
Ravidassias of Punjab, especially those associated with the Dera Ballan, have been the most vocal about this changed scenario. Dera Ballan belongs to the prosperous Doaba region, often referred to as the NRI region of Punjab. The community has historically been affluent and influential owing to its traditional monopoly of leather business since colonial times. Backed by the head start in the economic sphere, the Ravidassias over the century have spread across continents with sizeable numbers in countries like Italy, Austria, Canada, UK and the USA.
Locally placed Ravidassias, almost entirely non-landed in Punjab, like the other Dalits, too benefitted from access to non-farm occupations, mostly in urban areas, as the local agrarian relations became less favourable with the entry of migrants from other poor pockets of the country.
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Guru Ravidass, his teachings are relevant even today: Prof Santosh K Singh - The Indian Express
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FDA retains oversight of genetically modified animals for therapeutics amid last-day Trump regulatory changes – pharmaceutical-technology.com
Posted: at 3:22 am
On former president Donald Trumps last day in office, the US Department of Health and Human Services (HHS) and US Department of Agriculture (USDA) agreed that oversight of genetically modified (GM) animals for food will move from the FDA to the USDA. The FDA, however, retains oversight of gene editing intended for any purpose other than agricultural use, including Bio/pharma and gene therapies. The Trump administrations decision to relax oversight of GM animals for food prioritises big businesses and the livestock industry, while overriding FDA scientists in decisions around GM animal use. The thenFDA commissioner Stephen Hahn expressed concerns about potential public health consequences of relaxing regulations around certain GM products. After the announcement he tweeted, FDA has no intention of abdicating our public health mandate. It is unclear whether President Bidens administration or the FDA commissioner to be nominated will support these regulatory changes to agricultural biotechnology.
A GM animal is one whose genetic material has been altered by adding, changing, or removing certain DNA sequences in a way that does not occur naturally. GM animals are in development for many potential uses in Bio/pharma, including for pharmaceutical drug production, as research models of human disease, and in xenotransplantation to make cells, tissues, or organs for transplantation into humans.
According to the GlobalData Pharma Intelligence Center Drugs database, several therapeutic recombinant biologic drugs are produced in transgenic (GM) animal expression systems, including four marketed drugs (Figure 1). In 2009, the FDA approved rEVO Biologics antithrombin (recombinant) produced in the milk of GM goats for patients who have a rare disease known as antithrombin (AT) deficiency. Pharmings Conestat alfa, a human recombinant C1 esterase inhibitor purified from the milk of GM rabbits, was approved by the FDA in 2014 for the treatment of hereditary angioedema. In 2015, the FDA approved Alexion Pharmaceuticals sebelipase alfa for a rare genetic disease known as lysosomal acid lipase (LAL) deficiency, produced in the egg whites of GM chickens. In 2019, the FDAs Center for Veterinary Medicine (CVM) approved a GM rabbit that produces the active ingredient of LFBs coagulation factor VIIa (recombinant). The therapeutic was approved in 2020 for the treatment and control of bleeding episodes occurring in adults and adolescents with haemophilia A or B with inhibitors. In addition, Pharming Group has one Phase III and two preclinical-stage candidates in development, which are produced using the companys transgenic rabbit platform.
Table 1: Marketed/Pipeline Pharmaceutical Drugs That Use Genetically Modified Animals for Production.
With new gene-editing techniques such as CRISPR-Cas9 making genetic engineering faster and cheaper, transgenic animals offer the potential to make the manufacturing of complex therapeutic proteins cheaper. Despite these advantages, however, progress in the field has been slow due to public concerns over GM animals, including the safety of products derived from these animals. In this regard, it restores confidence that the FDA will retain oversight of GM therapeutic products, amidst the proposed transfer of regulatory power over certain gene-edited animals.
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FDA retains oversight of genetically modified animals for therapeutics amid last-day Trump regulatory changes - pharmaceutical-technology.com
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Poseida Therapeutics Provides Update on Key Programs and Developments During R&D Day – PRNewswire
Posted: at 3:22 am
SAN DIEGO, Feb. 24, 2021 /PRNewswire/ --Poseida Therapeutics, Inc. (NASDAQ: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, today announced that the Company plans to highlight its clinical and preclinical pipeline progress during a virtual R&D Day to be held today, February 24, 2021 beginning at 10am ET.
"Over the past year, we have made tremendous progress as we continue to validate our novel technology platforms and advance our broad and deep clinical and preclinical programs," commented Eric Ostertag, M.D., Ph.D., Chief Executive Officer. "During today's R&D Day, we will take a deep dive into Poseida's novel cell and genetic engineering platform technologies, differentiated CAR-T programs and innovative approaches to cell and gene therapy. We look forward to highlighting our progress to date, introducing a new potential pipeline product candidate, as well as several emerging discovery programs, and discussing our corporate strategy."
Specific highlights will include an early look at the ongoing P-PSMA-101 clinical trial; demonstration of the potential for single treatment cures with a completely non-viral nanoparticle-based gene therapy system; an extensive study of our Cas-CLOVER Site-Specific Gene Editing System demonstrating best-in-class gene editing specificity; and a look at our CAR-NK, and induced pluripotent stem cell, or iPSC, capabilities.
Key Program Highlights
Autologous CAR-T Update P-BCMA-101 is an autologous CAR-T product candidate in an ongoing Phase 1 dose expansion trial and Phase 2 trial in development for the treatment of relapsed/refractory multiple myeloma to treat patients with multiple myeloma. Today's discussion will include data demonstrating the importance of T stem cell memory in CAR-T. The Company intends to provide an update on this program later in 2021.
P-PSMA-101 is a solid tumor autologous CAR-T product candidate in an ongoing Phase 1 dose escalation trial in development to treat patients with metastatic castrate resistant prostate cancer, or mCRPC.Today's presentation will include a case study of a patient with mCRPC treated with P-PSMA-101 at a dose of 0.25 x 10e6 cells/kg (~20 x 10e6 total cells) who showed a marked decrease in PSA expression levels of more than 50% in the first three weeks post treatment and is continuing on trial. The patient was reported to have Grade 1 CRS in the second week which was treated to resolution. The Company intends to provide an additional update on this program later in 2021.
Allogeneic CAR-T Update (including Cas-CLOVER off-target analysis) P-BCMA-ALLO1 is the Company's first allogeneic CAR-T product candidate in development for the treatment of relapsed/refractory multiple myeloma.The Company will present updated preclinical data and ongoing IND enabling work, with an expected filing in the first half of 2021. Data utilizing Cas-CLOVER, the Company's high-precision gene editing technology to eliminate knock out TCR and B2M to address alloreactivity in P-BCMA-ALLO1, will also be presented.
P-MUC1C-ALLO1 is the Company's allogeneic CAR-T product candidate currently in preclinical development, with the potential to treat a wide range of solid tumors, including breast and ovarian cancers. The Company will share updated preclinical data demonstrating complete tumor elimination in triple negative breast and ovarian cancer models.P-MUC1C-ALLO1 will be the first clinical product to be manufactured at Poseida's pilot manufacturing facility in San Diego, with an IND filing expected by the end of 2021.
piggyBac Delivery in vivo for Liver Directed Gene Therapies P-OTC-101 is the Company's first liver-directed gene therapy program for in vivo treatment of urea cycle disease caused by congenital mutations in the OTC gene, a condition characterized by high unmet medical need. Preclinical data from ongoing IND enabling studies will be presented by Bruce Scharschmidt, M.D., an expert in OTCdeficiency and a consultant to Poseida.
Denise Sabatino, Ph.D., a recognized expert in Factor VIII therapy for Hemophilia, will present the Company's piggyBac Factor VIII program for hemophilia A, P-FVIII-101, delivered by Poseida's proprietary nanoparticle technology.Nanoparticle plus piggyBac delivery of Factor VIII demonstrates near normal levels of Factor VIII expression in juvenile mice with a single treatment in preclinical models.
Emerging Programs TCR-T: Poseida's TCR-T platform combines the Company's piggyBac DNA delivery and Cas-CLOVER gene editing technologies in order to generate effective and functional off-the-shelf TCR-T product candidates with a high percentage of highly desirable Tscm cells.The TCR-T platform could be leveraged to increase the number of potential indications in oncology and beyond, including infectious diseases and autoimmunity.
Anti-cKit CAR-T: Safer non-genotoxic conditioning regimens are potentially possible with the Company's anti-cKit CAR-T program for hematopoietic stem cell, or HSC, conditioning, which may reduce transplant morbidity and mortality, resulting in better outcomes and a greatly expanded number of potential indications. Data include results from preclinical experiments demonstrating the ability of anti-cKit CAR-T cells to deplete human stem cell grafts in NSG mice and to prolong survival in a mouse model of AML.
Genetically Modified HSCs:HSCscan be modified via the piggyBac DNA Delivery System and/or the Cas-CLOVER Site-Specific Gene Editing System. Today's presentation will show data confirming that genetically modified HSCs engraft in the bone marrow and demonstrate long-term persistence. CAR-HSC has the potential to be a highly effective CAR-T approach, as it theoretically could provide an inexhaustible supply of effector cells to eradicate tumor and can be differentiated to generate high yields of CAR-T, CAR-NK and CAR-myeloid cells.
iPSCs:Cas-CLOVER is also efficient for creating knockouts and knock-ins in induced pluripotent stem cells, or iPSCs, with very low toxicity. Data will be presented showing the greater efficiencies of Cas-CLOVER as compared to an industry standard editing platform for therapeutic knock-in using plasmid DNA.
Genetically Modified NK Cells:The Company will also present data on efficient genetic modification of NK Cells using piggyBac and Cas-CLOVER platform technologies. The Cas-CLOVER gene editing system can be used to efficiently edit NK cells, or CAR-NK cells, while piggyBac can be used to effectively deliver large therapeutic transgenes to activated or un-activated peripheral blood NK cells which maintain CAR expression, phenotype, and function. Several emerging potential CAR-NK cell product candidates will be revealed, all of which demonstrate specific killing of cancer cells.
R&D Day Webcast InformationA live webcast of the Company's R&D Day event will be available on the Investors & Media section of Poseida's website, http://www.poseida.com. A replay of the webcast will be available for 30 days following the presentation.
About Poseida Therapeutics, Inc.Poseida Therapeutics is a clinical-stage biopharmaceutical company dedicated to utilizing our proprietary gene engineering platform technologies to create next generation cell and gene therapeutics with the capacity to cure. We have discovered and are developing a broad portfolio of product candidates in a variety of indications based on our core proprietary platforms, including our non-viral piggyBac DNA Modification System, Cas-CLOVER site-specific gene editing system and nanoparticle- and AAV-based gene delivery technologies. Our core platform technologies have utility, either alone or in combination, across many cell and gene therapeutic modalities and enable us to engineer our wholly-owned portfolio of product candidates that are designed to overcome the primary limitations of current generation cell and gene therapeutics. To learn more, visit http://www.poseida.com and connect with us on Twitter and LinkedIn.
Forward-Looking StatementsStatements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such forward-looking statements include statements regarding the clinical data presented, the potential benefits of Poseida's technology platforms and product candidates and Poseida's plans and strategy with respect to developing its technologies and product candidates. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. These forward-looking statements are based upon Poseida's current expectations and involve assumptions that may never materialize or may prove to be incorrect. Actual results could differ materially from those anticipated in such forward-looking statements as a result of various risks and uncertainties, which include, without limitation, risks and uncertainties associated with development and regulatory approval of novel product candidates in the biopharmaceutical industry, the fact that future clinical results could be inconsistent with results observed to date and the other risks described in Poseida's filings with the Securities and Exchange Commission. All forward-looking statements contained in this press release speak only as of the date on which they were made. Poseida undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made, except as required by law.
SOURCE Poseida Therapeutics, Inc.
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Poseida Therapeutics Provides Update on Key Programs and Developments During R&D Day - PRNewswire
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Catalent continues cell and gene therapy push with deal for Belgian CDMO – FiercePharma
Posted: at 3:22 am
Catalent's Belgian manufacturing foothold is widening, as the company moves to acquire yet another cell and gene therapy CDMO in the area.
Catalent locked in a deal tobuy 100% of the shares of Delphi Genetics, a plasmid DNA cell and gene therapy CDMO based out of Gosselies, Belgium. The move will help speed the start ofcommercial plasmid manufacturingat Catalent'sfacility in Rockville, Maryland, and add to the CDMO'sfast-growing hubin Gosselies.
As part of the deal, Catalent will get its hands on Delphi's STABY technology, an antibiotic-free selection system used to make plasmids and proteins in E. coli, which it plans totransfer to its Rockville site,Colleen Floreck, VP of global marketing and strategy at Catalent Cell and Gene Therapy, said via email.
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Learn how IPM.ai transformed real world data into real world insights to assist Audentes in their development of AT132 for the treatment of XLMTM. The session reviews how IPM.ia and Audentes collaborated to uncover the XLMTM patient population.
RELATED:Catalent injects $130M into Maryland cell and gene therapy site drafted into COVID-19 vaccine hunt
Since picking up the Rockville facility in 2019, Catalent has brought its plasmid capacity online to the tune of 50 liters and is now tackling R&D production there for early-phase customers, Floreck said. The company is now installing three more manufacturingsuites at the plant, she added.
The facility also boastsprocess and analytical development services, and will eventually be used to take viral vector partners' work from early development through commercialization, Floreck said.
The takeover will also see Delphi's Gosselies home base become the latest addition toCatalent's cell and gene therapy operation in the region, Delphi CEOFranois Blondel said in a release. In fact, Delphi's 17,000-square-foot manufacturing facility and headquarters is located right next to Catalent's existing facilities there.
Catalent made its first foray into Belgium last February, layingout$315 million to acquireMaSTherCellGlobal, a cell and gene therapy CDMO with operations in Gosselies and Houston, Texas.Alongside MaSTherCell's existing25,000-square-foot clinical services facility in Belgium, Catalent snagged a60,000-square-foot commercial-scale and fill-finish facility in progress, which will eventually employ 250 when the project wraps later this year.
RELATED:CDMO Catalent tackles Warp Speed juggling act with new $50M Bloomington line, Acorda plant buyout
Catalent made moves on anotherGosselies site in October, buying a31,000-square-foot cell and gene therapy plant from Bone Therapeutics for $14 million.
The Delphi deal, expected to close "in the next week," will fold the company's current workforce of 38 into Catalent's cell and gene therapy business unit, Floreck said. That team consists ofR&D and genetic engineering scientists and technicians, regulatory specialists, leadership and more, she said. Catalent didn't disclosehow much it will pay for Delphi.
Delphi, which spun off from the Universit libre de Bruxelles in 2001, boasts "one-stop-shop" CDMO services for preclinical work up to phase 3, includingprocess development, pilot production, plasmid design and production, strain screening and stability.Plus, just last March, Delphimore than tripled its plasmid production capacity in Gosselies, courtesy of three new manufacturing suites.
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22nd Century Group to Host Webcast to Discuss Fourth Quarter and Full-Year 2020 Results – GlobeNewswire
Posted: at 3:22 am
WILLIAMSVILLE, N.Y., Feb. 25, 2021 (GLOBE NEWSWIRE) -- 22nd Century Group, Inc. (NYSE American: XXII), a leading plant-based, biotechnology company focused on tobacco harm reduction, very low nicotine content tobacco, and hemp/cannabis research, will host a live audio webcast on Thursday, March 11, 2020, at 8:00 a.m. Eastern Standard Time to discuss its 2020 fourth quarter and full-year results. 22nd Century will report the Companys fourth quarter and full-year 2020 results in a press release at 7:00 a.m. Eastern Standard Time the same day.
During the webcast, James A. Mish, chief executive officer; Michael Zercher, chief operating officer; and John Franzino, chief financial officer, will review the Companys 2020 fourth quarter and full-year results and provide details on near-term milestones and exciting medium and long-term priorities in the more than $800 billion addressable markets 22nd Century Group targets, including tobacco and hemp/cannabis. The Company will also address potential political and regulatory changes that may benefit the Companys market opportunities.
Following prepared remarks including an accompanying slide presentation, the Company will host a Q&A session during which management will accept questions from interested analysts. Investors, shareholders, and members of the media will also have the opportunity to pose questions to management by submitting questions through the interactive webcast during the event.
The live and archived webcast, interactive Q&A, and slide presentation will be accessible on the Events web page in the Company's Investor Relations section of the website, at http://www.xxiicentury.com/investors/events. Please access the website at least 15 minutes prior to the start of the webcast to register and, if necessary, download and install any required software.
About 22nd Century Group,Inc.22nd Century Group, Inc. (NYSE American:XXII) is a leading plant biotechnology company focused on technologies that alter the level of nicotine in tobacco plants and the level of cannabinoids in hemp/cannabis plants through genetic engineering, gene-editing, and modern plant breeding. 22nd Centurys primary mission in tobacco is to reduce the harm caused by smoking through the Companys proprietary reduced nicotine content tobacco cigarettes containing 95% less nicotine than conventional cigarettes. The Companys primary mission in hemp/cannabis is to develop and commercialize proprietary hemp/cannabis plants with valuable cannabinoid profiles and desirable agronomic traits.
Learn more atxxiicentury.com, on Twitter@_xxiicentury, and onLinkedIn.
Cautionary Note Regarding Forward-Looking StatementsExcept for historical information, all of the statements, expectations, and assumptions contained in this press release are forward-looking statements. Forward-looking statements typically contain terms such as anticipate, believe, consider, continue, could, estimate, expect, explore, foresee, goal, guidance, intend, likely, may, plan, potential, predict, preliminary, probable, project, promising, seek, should, will, would, and similar expressions. Actual results might differ materially from those explicit or implicit in forward-looking statements. Important factors that could cause actual results to differ materially are set forth in Risk Factors in the Companys Annual Report on Form 10-K filed on March 11, 2020, and in its subsequently filed Quarterly Report on Form 10-Q. All information provided in this release is as of the date hereof, and the Company assumes no obligation to and does not intend to update these forward-looking statements, except as required by law.
Investor Relations & Media Contact:Mei KuoDirector, Communications & Investor Relations22nd Century Group, Inc.(716) 300-1221mkuo@xxiicentury.com
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8 ways business managers can use fiction to prepare for the uncertain reality of coronavirus – The Conversation CA
Posted: at 3:22 am
Reading fiction has always been, for many, a source of pleasure and a means to be transported to other worlds. But thats not all. Businesses can use novels to consider possible future scenarios, study sensitive workplace issues, develop future plans and avoid unplanned problematic events all without requiring a substantial budget.
During the COVID-19 pandemic, many business leaders have learned how important it is for businesses to consider a wide range of possible outcomes and to enhance organizational adaptability. Relying on analyzing or projecting trends and extending what business leaders usually do is no longer enough to assure future success. When management is poorly prepared for the unexpected, businesses start getting into trouble.
Scenario planning, therefore, helps businesses keep themselves flexible and move quickly with market shifts. Scenario planning is a series of potential stories or possible alternate futures in which todays decisions may play out. Such planning can help managers assess how they or their employees should respond in different potential situations.
Unfortunately, scenario planning requires time and resources. And depending on its use, such as for an investigation, budgeting or legal matters, it can also require collecting sensitive data. That can include employees personal experiences of sexual, discriminatory or psychological harassment, suicide, mental health, drug abuse, etc.
The more sensitive the needed data is, the more difficult it is to collect while ensuring employee privacy. This is where literary texts come in.
As sources for possible future scenarios capable of providing strategic foresight, or producing alternative future plans, novels can also help businesses create dialogue on difficult and even taboo subjects.
Novels are, therefore, capable of helping managers become better, providing them with creative insight and wisdom. Science fiction can provide a means to explore morality tales, a warning of possible futures, in an attempt to help us avoid or rectify that future.
Our research uses Aldous Huxleys 1932 novel Brave New World to explore possible scenarios related to situations that are usually kept confidential, such as employees mental health issues and drug use or abuse. We examined how employers encounter uncertainty around the impact that legalizing cannabis could have on the work environment, and ways to consider such potential effects.
Brave New World is set in a dystopian future and has been adapted numerous times, most recently into a 2020 TV series. It portrays a dystopic civilization whose members are shaped by genetic engineering and behavioural conditioning. Their happiness is maintained by government-sanctioned drug consumption. It is a world where countries are protected by walls that keep the undesired away an eerily familiar scenario to Donald Trumps promise of building a wall on the U.S.-Mexico border.
By reading the novel, business managers can compare the world we live in today and the path our countries and corporations are on to the fictional events in the novel. This can help them pay attention to and address less comfortable, and sometimes often neglected, sensitive workplace issues that need to be considered when planning for the future.
For example, in Brave New World, the consumption of the drug soma becomes the norm upon which life is founded. When soma is taken away, individuals can no longer face their reality and they end up welcoming death.
Brave New World offers workplace leaders a look at what could happen if employees wellness, mental health or drug use are disregarded, and lead to isolation, absence, resignation or, in dire circumstances, suicide.
To study sensitive workplace issues that could help generate new knowledge, lead to envisioning ways to act appropriately and develop future strategies, business managers can follow these steps:
Form a team of managers and an HR representative who is aware of company policies and ethics protocols, and is in direct contact with employees.
The team then decides which workplace issue(s) the organization needs to study.
The team chooses a literary text, such as a novel, that discusses those issues.
Each member of the team reads the literary text on their own before discussing it together in at least one session.
The team researches the chosen workplace topics inside the organization and outside (for example, laws and regulations related to each issue).
The team identifies insightful sections.
The team analyzes the chosen extracts.
The team writes a report with recommendations on workplace conditions and how best to improve them.
Reading has surged during lockdown. But literary works can provide us with more than a leisurely pastime. For businesses, novels represent a legitimate way to study the workplace, and this is accomplished by comparing the path our countries and corporations are on today to fictional events.
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8 ways business managers can use fiction to prepare for the uncertain reality of coronavirus - The Conversation CA
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A Liberal Case for Seapower? – War on the Rocks
Posted: at 3:19 am
Editors note: This essay is the third in a series of eight articles, Maritime Strategy on the Rocks, that examines different aspects and implications of the recently released tri-service maritime strategy, Advantage at Sea: Prevailing with Integrated All-Domain Naval Power. Be sure to read thefirst article and second article. We thank Prof. Jon Caverley of the U.S. Naval War College for his assistance in coordinating this series.
Given the many nakedly self-serving, politically desperate, and anti-liberal foreign policy moves of the lame duck administration of former President Donald Trump, the incoming team of President Joe Biden might understandably treat the recently released tri-service maritime strategy in a similar fashion to Trumps proposed 2022 budget: with skepticism. Americas sea services have been at the forefront of the Trump administrations last-minute national security maneuvers with the December releases of both a new 30-year shipbuilding plan and the new maritime strategy. Trump loved talking about building ships (although he did little to advance this goal), shattering precedents by sending his National Security Advisor to campaign on naval construction in battleground states and openly suggesting that the Navy consider his political prospects when choosing to build its new frigate in Wisconsin. But, despite this, the new administration should take the new strategy document seriously, as the three naval services have produced a strikingly liberal vision.
By liberal, we do not mean Democratic (or even democratic; there is no mention of democracy in the strategy), but rather, the suite of policies and beliefs associated with the long term and largely bipartisan American approach to foreign policy. While the Pentagon prefers the term rules-based to liberal to describe this international order, both terms are synonymous with the system of alliances, free trade, open global commons, conflict management, international institutions, and the more than-occasional bout of coercion that has been central to Americas approach to international politics since the end of World War II. The Biden administration has clearly signaled its intent to steer American foreign policy back in this direction as an intrinsic component to competition with China, reacting to Trumps internationally confrontational America First policy.
Granted, with the strategys focus on great-power competition, there is plenty of muscular realism in the document, especially when compared to the last one, which was published in 2015. For cultural, budgetary, and strategic reasons, the Navy has always prioritized an offensive sea control and power projection approach to the Western Pacific as its core mission as opposed to a more presence- and denial-focused fleet deployed around the world. The Marine Corps signature initiative is deploying newly developed Marine Littoral Regiments to fight in actively contested maritime spaces in the Pacific. Nonetheless, we argue that the same forces posited by the strategy (and its associated shipbuilding plan) for a Sino-American slugfest can also serve a less directly confrontational approach to great-power competition, and indeed, the strategy clearly lays out a liberal logic for seapower. Barring catastrophic war, competition with China will likely take place around the world over goods and issues held in common across many states. Managing conflict in this system, providing public goods, and protecting sea lanes is facilitated by building a larger U.S. Navy.
More Ships Allow for More System Management
Institutions write strategy documents, in no small part, to plead for more resources, selling their centrality to U.S. security. But much of the maritime services case, however self-serving, happens to be true, backed up by data on 270 interstate maritime conflicts. The data show that U.S. naval power correlates to a strong downward effect on the frequency and escalation of maritime conflicts (Figure 1) and that maritime conflicts are increasing relative to territorial disputes. The future of conflict is likely to be maritime. This is especially the case if one holds the liberal belief that great-power competition is as much a matter of international system maintenance, conflict management, and public goods provision as it is direct military confrontation between superpowers.
The most likely friction points between China and the United States will be at sea, in the air, and in space: the global commons. China is involved in 10 ongoing maritime disputes (Russia in nine). But that leaves 77 disputes around the world 80 percent that do not involve a great-power opponent of the United States. Actively managing, if not resolving, these potential crises is an important part of maintaining a liberal order, making the world safer for commerce, and making other states more amenable to U.S. leadership. A hallmark of U.S. liberal grand strategy is dispute resolution and conflict management, and in the modern era, these clashes occur more often at sea than on land. Territorial disputes (e.g., Kashmir and Nagorno-Karabakh) have declined over the past two centuries, but contentious maritime claims (e.g., the Spratly Islands and the Aegean Sea) have increased significantly.
One major reason why maritime disputes will continue to increase is climate change. Unlike the most recent National Security Strategy, National Defense Strategy, and National Military Strategy, the sea services explicitly acknowledge its existence. The maritime strategy observes that climate change threatens coastal nations with rising sea levels, depleted fish stocks, and more severe weather and also claims that [c]ompetition over offshore resources, including protein, energy, and minerals, is leading to tension and conflict. Both statements are on firm empirical ground. Data show that climate volatility, especially variability in rainfall, exacerbates the risks for militarized clashes at sea. Warmer oceans increase scarcities in many fisheries stocks by changing migration patterns, increasing fish mortality rates, and changing water acidity levels, and thus, we may see greater escalation over contested fishing grounds in the future. The use of maritime militias by countries like China, Vietnam, and the Philippines to defend fishing grounds is not surprising as states expand security measures to protect their citizens access to fish stocks.
There are, of course, many causes for the relative increase in disputes at sea, but it is undeniable that the rise in maritime disputes correlates to a decline in U.S. naval tonnage as a percentage of the worlds navies (Figure 1). Rising sea powers as diverse as Russia, Egypt, Indonesia, India, Iran, and North Korea have sought to expand sovereignty over maritime spaces, increasing risks for future conflicts. These regional conflagrations are risky, too, because major power wars often arise through alliance ties and the failure of extended deterrence.
The data show that, while maritime crises rarely escalate to open military conflict, naval power is the only maritime capability that deters escalation. No matter how capable or large a state is in terms of broader measures of power, naval forces are essential for this task.
Erik Gartzke and Jon Lindsay argue in a forthcoming article in this series that states that build more surface ships and submarines and challenge their neighbors maritime sovereignty claims fight in more militarized conflicts. By this logic, naval investments by China, Japan, and Taiwan would increase the risks for clashes at sea, and these have occurred. But, rather than the growth of individual fleets, it is the regional naval balance, and the role played by the United States in it, that matters most. Senkaku/Diaoyu conflicts have not resulted in war largely due to naval parity between these actors and the capability balance that the United States offers. The data show, more generally, that maritime disputes between evenly matched naval powers are more likely to be settled through peaceful negotiations. This supports the strategys claim that [a]ctivities short of war can achieve strategic-level effects. The maritime domain is particularly vulnerable to malign behavior below the threshold of war and incremental gains from malign activities can accumulate into long-term advantages. Plenty of evidence exists to support a larger fleet regardless of who is in the White House.
Figure 1: U.S. Naval Power Share (based on total tonnage) and Annual Number of Ongoing ICOW Maritime Claims.
The maritime strategy envisions an expansion of the fleet to concentrate on the high-end fight, particularly against China. The services primary means of doing so is what the Navy calls Distributed Military Operations: using larger numbers of smaller combatants (manned and unmanned) to mass overwhelming combat power and effects at the time and place of our choosing. This capability is unlikely to be used. As in the Cold War, a direct conflict between China and the United States would be incredibly dangerous but also incredibly unlikely. The hot portion of the Cold War unfolded in locations where the two superpowers didnt face each other directly: not only in wars like Vietnam and Afghanistan but in competitions for influence with countries like Egypt, India, and Yugoslavia. Unlike the Cold War, China and the United States appear somewhat more evenly matched in the economic, ideological, and security tools they can employ in a renewed superpower competition over proxies.
For all the focus on marshaling a larger, lighter, and cheaper Navy for a major conflict at sea, these ships are fungible and can do much of the day-to-day management of the maritime commons conflict de-escalation, protection of trade routes, and humanitarian operations as well as power projection against smaller opponents. Similarly, the Marines divestment from heavy armor will make the Corps more agile in a Western Pacific fight but also optimize it for rapid deployment globally. Pushing white-hulled Coast Guard vessels further from the United States may help manage crisis without escalation.
The Liberal Services?
But beyond the larger number of ships, the roles the maritime services assign to themselves hew closely to many tasks a Biden administration will likely call for. A fleet can be a profoundly liberal foreign policy tool for better or worse and this is reflected in the language of the strategy.
The strategy describes five lines of effort for operating across the competition continuum with the term combat only found in the final one. The first, advance global maritime security and governance, declares an intent to operate with allies, partners, other U.S. agencies, and multinational groups to maintain a free and open maritime environment and uphold the norms underpinning our shared security and prosperity. One would be hard-pressed to encapsulate the logic of liberalism and collective security in a shorter sentence. If you are mad about Trump damaging Americas standing in the world and plan on restoring U.S. reputation and credibility around the globe, you are going to need a navy.
The second line of effort doubles down on alliances and partnerships. Throughout the strategy, the services employ the term allies more times than China. Naval diplomacy and reassurance of smaller states have long been an essential aspects of keeping alliances together. Beyond formal allies, the United States and China are clearly locked in a competition over who can provide the better package of economic and security benefits to small but strategically located states. All three maritime services can play a constructive and largely non-escalatory role. Evidence exists that military presence and coordination among states enhances deterrence.
The third line of effort, confront and expose malign behavior, assigns great political power to the services ability to provide transparency to international politics around the world. The practice of international naming and shaming, while optimistic about its effect on international politics, is a tool firmly associated with a liberal approach.
Perhaps even more striking for a liberal reader is the strategys mention of the International Maritime Organization. Not many other recent Pentagon documents give such prominence to an arm of the United Nations. A new administration should pair this approach with a renewed effort to ratify the Law of the Sea Convention given its effective record in preventing and deescalating maritime conflicts. After all, maritime conflicts often occur between democratic countries, and thus, the United States must be prepared to mediate maritime clashes between allies to keep both alliances and the liberal international order intact.
Maritime Dilemmas for Liberals
To be sure, while the strategy and the fleet itself contain the components of a liberal approach to security, Democrats may take a different approach than the one laid out in the strategy. Ships are not cheap. The Trump administrations proposal calls for an 86 percent increase in Navy ship numbers and a 44 percent increase in shipbuilding funds over the next five years. Then again, the Coast Guard, perhaps the only popular part of Homeland Security among progressives, could be boosted outside of the defense budget in ways more acceptable to congressional Democrats. The strategys advocacy for recapitalizing an undersized American merchant fleet that can be mobilized for wartime logistics also seems an easier sell. And lets not forget that many of these new ships will be built in battleground states such as Wisconsin and Maine.
Beyond budget concerns, the Navy continues to struggle with managing basic dilemmas and will need strong and careful civilian leadership from the new White House and Office of Secretary of Defense. These dilemmas were not solved by the Navy or Trump, and now they fall squarely in the new administrations lap.
First, the Navy has yet to figure out how to balance between operating day-to-day and preparing for war, the age-old dilemma of a great-power fleet. A large naval force capable of coalescing in a high-end fight is also a flexible one. The new administration will need to referee between them. Using the fleet for system management as part of a liberal foreign policy can be effective for maintaining peace abroad, but that will entail a tradeoff in developing and conserving decisive combat power for deterring (and ultimately fighting) a great power like China. The Navy is currently suffering from severe overuse, and an activist, liberal foreign policy will need to suppress its appetite.
Second, the strategy claims ready, forward-deployed naval forces will accept calculated tactical risks and adopt a more assertive posture in our day-to-day operations without defining what these risks might be. Increased deterrence rarely comes for free. These risks can also lead to crisis instability and escalation. The Navy must be honest with civilian leaders about what this entails, and these leaders must take the time to understand them.
Third, both the strategy and Trumps 30-year shipbuilding plan bet heavily on unmanned systems. The Navy and Marine Corps accept that unmanned systems will play an important role in the future fleet but have struggled to incorporate them into concepts of operations or decide what capabilities need to be placed on these platforms. Moreover, the services have found themselves caught between an enthusiastic Office of the Secretary of Defense and a skeptical Congress. While the wartime role for these weapons seems somewhat apparent, how unmanned systems contribute to the more liberal, system maintenance role envisioned by the strategy remains a mystery.
Finally, while the data make clear the role a fleet can play in conflict management, analysis fails to support one core aspect of systems management favored by presidents from both parties as well as the Navy: freedom of navigation operations. The maritime forces and their bosses will have to come up with more creative ways to compete in the gray zone.
Conclusion
A strong naval service operating routinely around the world has historically been viewed as the prerequisite for a liberal international order. Data support this idea, showing that maritime conflicts between countries are less frequent and managed more effectively when the U.S. achieves sea power dominance and helps to maintain naval parity in allies conflicts. Even eloquent advocates of moderating U.S. foreign policy ambition view the Navy as the military capability most essential for protecting Americas national interests. Its no coincidence that the cover for Barry Posens book Restraint features three U.S. surface ships on the cover.
The Biden administration should not confuse Trumps enthusiasm for ships with a coherent vision of the naval forces role in his America First approach to the world. The writers of this tri-service strategy certainly did not. Trump wasnt much of a globalist, but curiously, the maritime strategy published at the end of his administration is well-suited to support a liberal approach to international politics.
Jonathan D. Caverley is a professor in strategic and operational research at the United States Naval War College and a research scientist in political science and security studies at the Massachusetts Institute of Technology. His views do not reflect official positions of the United States Naval War College, Navy, or Department of Defense.
Sara McLaughlin Mitchell is the F. Wendell Miller Professor of political science at the University of Iowa. She is co-director of the Issue Correlates of War Project.
Image: U.S. Navy (Photo by Mass Communication Spc. 3rd Class Will Hardy)
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Nehru did not repeatedly claim to be a liberal: Pankaj Mishra – The Hindu
Posted: at 3:19 am
The essayist and novelist on his latest book, Indian liberalism, the Hindu Rashtra and the evolving Western intellectual establishment
Pankaj Mishra is almost unique among Indian authors in having reflected consistently on modern history, contemporary politics and literary cultures, not only in India and South Asia but also in China, Anglo-America, Europe, West Asia, Southeast Asia and North Africa. His latest book, Bland Fanatics: Liberals, Race and Empire, is a collection of many of his important political essays and polemical pieces, published over the two decades since 9/11. In an interview, he discusses his current preoccupations.
I think the word liberal triggers hostility in India for reasons specific to Indias culture wars. Many of Modis critics claim to be liberal. They may not subscribe to many of classical liberalisms precepts, such as free trade. But they use the word and invoke its morally prestigious Western associations to present themselves as embodiments of a kind of udaarta tolerance and acceptance of different world-views.
For right-wingers, however, the word stands in for an English-speaking metropolitan class whose cultural hegemony they are fighting to overthrow. I think we should examine the genealogy of this word in India more closely, and who deploys it and for what reason. Its worth remembering that Nehru himself did not repeatedly claim to be a liberal in the way his present-day followers do. Nor did most significant figures of the freedom movement. I am not sure that many intellectuals and activists who work primarily in Indian languages describe themselves as liberal.
Yes, success and honour are almost exclusively reserved for those who flatter Western self-images and boosterish discourses prevalent in the West. I was often accused of making a living by running down India internationally when all I did was point to some serious problems confronting a vast majority of Indians. Ironically, those talking up the New India were being lavishly rewarded by the Western establishment that had bought into a fantasy of India as a great democracy, economic superpower, counterweight to China etc.
The propagandists are now in retreat, partly because the Western establishment has lost its old certainties in recent years, and spaces have opened up for discourses whether about imperialism and slavery or global capitalism, inequality and our ruined environment that it either suppressed or ignored. When The New York Times, which carried articles about the need for a new Anglo-American empire not so long ago, starts questioning with its 1619 project the accepted narrative of American freedom and democracy, the mainstream does not seem wholly resistant to some long overdue corrections.
Ideas often cross-pollinate in ways that would bewilder those who hold fast to moralising narratives about the rise of liberal democracy and Hindu Rashtra. The Nazis got many of their ideas about ethnic and racial supremacism from that great exemplar of liberal democracy: the U.S.. J.S. Mill assumed that Indians were a barbarian people, unfit for self-rule.
One reason why fascist mysticism remains potent is that it appears to address some stubborn pathologies of modern life alienation, isolation, anomie, powerlessness. Progress has become an Indian ideology in recent decades. But it is far from resolving (and might have aggravated) fundamental problems in the relationship of the self to the world, and the experiences of love, fear, hatred, and grief that are so often traumatic.
People will continue to seek palliatives for their pain and bewilderment in a variety of sources from Mein Kampf and QAnon to Aurobindos supra-mental consciousness.
I think the left in America is a very marginal force, shut out of both mainstream politics and journalism, despite, or perhaps because of, its formidable intellectual firepower. As such, it has the unique freedom to mount strong critiques of the establishment.
The new Barack Obama memoir is very revealing in this regard. He is obviously smarting over this tiny but intellectually vigorous lefts critique of his own establishment instincts. But the lefts critique is persuasive because Obama did little with the great energy for change that had exalted him to power; he missed the chance to boldly reform a corrupt and dysfunctional system, deferred too much to Wall Street and the old political and business elites, and ended up paving the way for Trump.
After that trauma, the left is naturally more suspicious of the deeply networked Democratic Party apparatchiks who are now in power and promise to restore normalcy. And lets not forget that nearly 75 million Americans voted for Trump, and Biden and Harriss victory is far from emphatic.
I feel that I have reached the end of the kind of writing that I began in the late 90s, with the nuclear tests and Kashmir, and then extended to the origins of 9/11, the war on terror, China and the fate of liberalism. In retrospect, those writings and the subsequent histories I published were my own attempt to understand a world that seemed to be dramatically changing and indeed unravelling, but which the triumphant assumptions of the intellectual and journalistic mainstream had made more or less incomprehensible.
Now, of course, the steady intellectual and political deterioration I wrote about, whether in India or in the U.S. and Britain, is no longer something that I have to repeatedly demonstrate to a sceptical readership. It is too painfully obvious. So, yes, it is time for me to explore other, more imaginative and personally fulfilling modes of writing.
The interviewer is an intellectual historian at the Centre for the Study of Developing Societies, New Delhi.
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Gov. Cuomo, his liberal critics, and the science of political decay – theday.com
Posted: at 3:19 am
"Follow the science" is what progressive Democrats demand when the science suits them.
And yet, like Pavlov's salivating dog and the meat powder, a whiff of New York Gov. Andrew Cuomo prompts a predictable, conditioned response: a barking chorus of "whatabout whatabout" Ted Cruz or other Republicans.
There are plenty of Republicans to choose from, but as Cuomo began to publicly dissolve, it was Cruz, the conservative senator of Texas, who served up an awkward feast of himself. Cruz flew to sunny Cancun while his constituents were suffering and dying without power during a killer cold snap. He made it worse with a weasel trick, shifting the blame to his family for his jetting off to Mexico. His sin was about optics. And he deserves to pay for it.
But it wasn't Cruz who ordered senior citizens infected with COVID-19 back into nursing homes. Cuomo did that. It wasn't Cruz who allegedly manipulated the numbers of nursing home deaths, now under federal investigation, while writing a book about his admirable handling of the health pandemic. Cuomo did that.
Cuomo's decisions regarding COVID-19 patients allegedly harmed thousands of seniors. Letitia James, Democrat and New York attorney general, issued a report on the undercounting of deaths. The New York Post reported on an admission of a cover-up, and investigations began amid Democrat vs. Democrat bullying and shrieking.
But is this just a New York fight or does it suggest a larger truth about where American politics is heading?
The progressives aren't merely influencing Democratic politics. In the deep blue states, they've taken control as the old party apparatus crumbles. The violent summer protests were about flexing muscle. Liberal Democratic mayors cowered and were overwhelmed in New York, Chicago, Minneapolis, Los Angeles, Portland, Oregon and Seattle.
Progressive muscle now is about taking out Cuomo, which is critical to protect the ambitions of their real champion, Vice President Kamala Harris. Prior to Cuomo's meltdown, oddsmakers already were evaluating a Cuomo vs. Harris matchup in the 2024 presidential primary.
"Cuomo is in trouble," David Marcus, the New York correspondent for the conservative Federalist site and other publications, including the New York Post, explained on my podcast, "The Chicago Way."
"(Rep. Alexandria Ocasio-Cortez) of New York called for an investigation. Democrats called for impeachment, taking away Cuomo's powers. It's a mess. The media is trying to protect him, but that's hard to do."
What Cuomo allegedly did to the seniors sentenced to death in New York nursing homes is his doing, his fault and his sin. His alone. Make no mistake about this. He deserves what's coming.
And what is happening to Cuomo is what happened to Democratic mayors in big cities during those "mostly peaceful" protests: The old Democrats are being devoured by the progressives who've taken control of urban politics.
"The Democratic Party in big cities is no longer the big machine that it once was, yet Cuomo still operates as if he's a boss of Democratic machine politics," Marcus said on "The Chicago Way."
"But this is a post-machine political age."
Indeed. It is a truth learned firsthand by every liberal Democratic big-city mayor during the summer, as their downtown business districts were looted and burned. The mayors might be liberal, but they're no match for the energy of the progressives. And the landscape that nurtured the old Democratic bosses, like the Daleys in Chicago, like Cuomo's own father, Mario, in New York, has shifted.
"Progressive groups like the 'justice Democrats,' are doing an end run around the party machines that no longer have the patronage operations that they once did," Marcus said. "And Cuomo's learning that. He's not the boss in the party the way his dad was in the 1980s. The politics are different.'"
What's changed is that the old bulls lost control. The new Democratic patronage is found in the public workers unions, the public-school teachers and others. They flexed their muscle in the summer. Now they want to use it some more. And they'll use it to rid the political world of possible rivals to Harris.
Until he began to collapse, Cuomo had been propped up by much of the media, by CNN in particular, in those painful, cloying interviews with his brother Chris, and by other outlets.
The governor was even given an Emmy for his handling of COVID-19 news conferences, an anti-Trump mannequin. But that's over.
Joe Biden is president. Cuomo fights for his life. Harris waits for an opening. Once the meat powder was in the air, the rest was inevitable political biology, where only the strong survive.
And that's science too, isn't it?
John Kass is a columnist for the Tribune Content Agency.
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