Daily Archives: February 21, 2021

How Algernon Pharmaceuticals is aiming to use psychedelics to aid stroke recovery – BNN

Posted: February 21, 2021 at 12:19 am

Attitudes towards current or former illicit drugs are rapidly changing worldwide. Dozens of countries and 16 U.S. states have legalized personal possession and consumption of cannabis even as research expands into its possible health applications.

Harm-reduction proponents are studying the use of the safe supply of hard drugs such as heroin to help hardcore addicts. And in the U.K., government regulators recently gave the go-ahead to the first clinical trial using a psychedelic drug to treat depression.

That change in attitude toward psychedelics, in particular coupled with research to be conducted by a Vancouver-based pharmaceutical company, could be revolutionary news for stroke patients.

Christopher Moreau, CEO, Algernon Pharmaceuticals Inc.

Algernon Pharmaceuticals (CSE: AGN | OTCQB: AGNPF | XFRA: AGW) plans to begin clinical trials this year on the use of N,N-Dimethyltryptamine (DMT), a psychedelic compound known as The Spirit Molecule, to help treat people who have suffered ischemic strokes.

Algernon is a clinical stage drug repurposing company that looks for new applications for drugs that are known and considered safe. It is the first company globally to pursue DMT treatment for ischemic stroke in humans, says its CEO, Christopher Moreau, who has more than 30 years of senior management experience in private and publicly traded companies, including a strong background in biotechnology research.

Pre-clinical study

The key for these Algernon clinical trials and the promise dimethyltryptamine presents to stroke patients, Moreau explains, is research from the Experimental Neurology Journal that shows DMT affects brain cells, aiding with rewiring, cell growth and making new connections, or neuroplasticity and neurogenesis.

Tests in labs have shown growth evidence of neuro cells when DMT was applied, he says, while animal testing demonstrated that treatment, produced in rats subjected to strokes, saw a smaller area of dead brain cells and the ability to recover motor function quicker.

And now, in preparation for the start of clinical trials with human subjects by the end of 2021, Algernon announced on February 8, 2021, that it had signed an agreement for pre-clinical research with Charles River Laboratories at its facility in Finland.

Microdoses are key

Algernons focus in planned and future trials is sub-hallucinogenic amounts, or microdoses, of DMT provided by continuous intravenous administration. The aim is to provide the potential brain-repairing benefits of the drug the growth of new cells and rewiring of neural pathways without the patient entering into the realm of the psychedelic experience.

And, if it is confirmed in the companys pre-clinical research phase that DMT could be used to treat both haemorrhagic and ischemic strokes, a patient would not have to wait for a CT scan and treatment could begin immediately even, possibly, in an ambulance en route to the hospital.

You can still get neurogenesis and neuroplasticity, Moreau says, referring to results of previous animal testing, Without giving a person a psychedelic experience.

But in addition to not wanting a stroke patient to also experience a psychedelic trip, microdosing may make a potential treatment easier to approve by licensing authorities.

As you deal with people in authority making decisions about laws and regulations, if they feel that a using a particular drug is counter to their personal beliefs in some way, that could restrict the speed with which drug trials get approved, Moreau explains. You also need to keep in mind that that even once a new drug or application of an existing drug is approved, doctors still need to be convinced its appropriate for their patients.

Massive market for treatment

Should Algernons trials succeed and its able to break barriers for therapeutic uses of psychedelics such as DMT, the potential number of patients is massive.

According to the Centers for Disease Control (CDC), more than 795,000 people die each year in the United States due to a stroke and for more than three quarters of those victims, its their first stroke. As well, about 87 per cent of all strokes are ischemic, in which a blockage in an artery decreases blood flow and oxygen to the brain, leading to damage to or death of brain cells.

The CDC also says stroke-related costs in the U.S. alone including health care services, medicines and missed work were almost USD$46 billion in 2014 and 2015.

Beyond the dollar costs are the human costs, the CDC reports, as strokes are the leading cause of long-term disability, reducing stroke survivors mobility in more than half of the cases.

Value in drug trials

The potential global market for a successful stroke treatment, then, is large and growing along with an aging population it was estimated at USD$8 billion in 2018 and is expected to reach USD$15 billion by 2027.

As well, the timeline for developing DMT as a stroke treatment may be compressed compared to other drug trials in which the effects and study periods take place over a long period. As a DMT trial will involve an acute treatment, by enlisting the help of multiple hospitals, its hoped a sufficient number of test subjects can be found in a shorter period perhaps a matter of months.

As well, its hoped Algernons approach may allow for a quicker pathway to regulatory approval, including a Breakthrough Therapy designation from the U.S. Food and Drug Administration.

Moreau says that successful Phase 1 trials in 2021 could lead to Phase 2 testing as early as 2022.

And he believes Algernon is well-placed for investors looking to gain value, noting that although the company has a $45-million market capitalization, a successful Phase 2 trial could increase that dramatically.

DMT isnt the only promising prospect on Algernons roster of repurposed drugs.

The company has also been testing the drug Ifenprodil for applications in the treatment of lung diseases in a Phase 2 trial in Australia. But when the pandemic hit last March, there was some indication that the drug might be able to reduce the severity of COVID-19 infections, so Algernon was approved for a multinational trial, with data expected by the end of this month.

With two drugs addressing two major global health concerns in the clinical trials pipeline, Moreau is optimistic about the health of both the company he leads and the patients who may be helped by its products.

For more information on Algernon Pharmaceuticals, visit their website here.

For more timely updates, follow Algernon on social media:

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How Algernon Pharmaceuticals is aiming to use psychedelics to aid stroke recovery - BNN

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Move to treat PTSD with psychedelics blocked by TGA – Tweed Daily News

Posted: at 12:19 am

The Therapeutic Goods Administration (TGA) has decided not to recognise psilocybin mushrooms (or magic mushroom) and MDMA (ecstasy) as medicines to treat a number of conditions, such as post-traumatic stress disorder, anxiety and other mental illnesses.

Although the TGA's decision is not final, it goes against what advocates want.

The request was raised by Mind Medicine Australia, a charity that advocates for psychedelics not to be restricted so mental health professionals can access such substances more easily.

In the case of medicinal psilocybin there were 575 responses of which 553 (96 per cent) were supportive, 11 partially supportive and 11 opposed.

In the case of medicinal MDMA, there were 478 responses of which 453 (95 per cent) were supportive, 14 partially supportive and 11 opposed.

This Mind Medicine Australia video explains the way they hope to use psychedelics to treat mental illnesses.

Both psilocybin and MDMA have been granted Breakthrough Therapy Status by the Food and Drug Administration in the USA to fast-track their approval.

On the Northern Rivers, one doctor that has been trained and says he could start helping people living with PTSD is Dr Jamie Rickcord.

Dr Rickcord was one of the first GPs approved to treat patients with psilocybin-assisted therapy in northern NSW.

He said he was disappointed but not surprised by the TGA's decision.

"Everyone in our society is operating with this unconscious stigma about drugs such as cannabis and psychedelics, but the truth is that they have been scientifically proven to be a lot safer than many of the drugs actually available, whether it's alcohol, opiates, benzodiazepines, amphetamines," he said.

"There are medical versions of opiates and amphetamines that are widely prescribed. Just because there is an illicit market, it doesn't preclude medical use. They can all be abused and they can all be used medically.

>>>Army veteran wants psychedelic drugs used in PTSD treatment

"Why on earth is there such a funk about cannabinoids and psychedelics?

"It's just another bracket of drugs that can be used medically, and they are safer than the ones that are already out there."

Dr Rickcord said MMA will continue trying to change the TGA's decision.

"We will make a submission saying that their decisions is valid and noted, and we will submit our response to their concerns, and if they say no, they will have to provide further reasons as to why are not prepared to reschedule the drugs (to make them available to doctors to use in patients)."

Submissions must be sent to the TGA by March 4. The TGA's final decision will be announced on April 22.

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Move to treat PTSD with psychedelics blocked by TGA - Tweed Daily News

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ATMA Unveils Canada’s First Psychedelic Journey Center, Offering 60 Acres of Immersive Healing and Transformation in the Foothills of the Rocky…

Posted: at 12:19 am

ATMA's Creekside Journey Center will provide a full range of services for mental health and psychological counselling, grounded in psychedelic-assisted therapy and treatment

CALGARY, AB, Feb. 19, 2021 /CNW/ - ATMA Journey Centers Inc. ("ATMA"), an Alberta-based company focused on delivering innovative psychedelic-assisted therapies internationally, revealed details today about the first Psychedelic Journey Center in Canada which will be located in central Alberta.

ATMA Journey Centers Inc. http://www.atmajourney.com (CNW Group/ATMA Journey Centers Inc)

The company will own and operate the private wellness center that is nestled within a retreat setting within a sprawling forest and nature, positioned approximately 2 hours from both Calgary and Edmonton. ATMA Creekside will provide a convenient destination in which clients will be able to experience a range of healing and transformational modalities as part of multi-day experiences, ceremonies, and retreats.

David Harder, Co-CEO of ATMA, said: "Creekside Journey Center begins the exciting rollout of our plans to create immersive retreat-style Journey Centers across Canada and beyond. Our aim is to position ATMA as the disruptor in a psychedelic renaissance that is so often focused on up-scaling the therapy."

Rather than focusing on patient through-put and optimizing to move as many people through medicine work as quickly as possible, the company says that its goal is to provide deeply immersive protocols that bring people inward and find life-long healing. The trend in psychedelic therapy appears to be in proprietary molecules and processes eligible to be patented or trademarked, but Harder points out that ATMA wants to provide a different experience.

"ATMA will be known for finding a place you can connect, find healing, and discover community," he said. "Our philosophy is that these deep inner medicine sessions are not best suited in a clinical appointment where only a few hours are allotted in the midst of a busy day and lifestyle. "

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Harder explained that the company's protocols are designed to be experienced over a number of weeks, and include, beyond the counselling and medicine work, time to connect with nature and others on a similar path. "This particular property at Creekside has a special energy to it, and with the incredible forest and relaxing creek that flows throughout the expansive property, we believe it's going to provide a magical space that will provide clients meaningful experiences and healing."

When the property opens this spring, it will provide full-service programs that include well-appointed cottages and suites, holistic and organic food prepared by certified chefs, and leading-edge psychedelic medicine therapy and protocols. The individual therapy sessions will be combined with group work which will intentionally provide both the individual processes needed to overcome mental health challenges as well as group journey opportunities where community can be fostered. A customized program of individual therapy sessions will occur both before and after the medicine work done at the Journey Center, allowing each client to be fully prepared for their experience and to have the support before and after their Journey Center visit.

"Our goal is to create an ultra-comfortable, safe and peaceful environment where the only thing a client needs to focus on is their own work and healing in a community of safe spaces and community support," said Harder. He explained that the company's vision is not to create a portfolio of medical-style psychedelic clinics located in busy urban centers. "Our business plan is to create nature-inspired destinations where a client can remove themselves from daily life for a few days or a week or more. We believe it's important they have space and time to really focus on doing the deep work that will provide shifts and changes that are sustainable and life-changing."

ATMA was the first private company in Canada to legally conduct psychedelic-assisted therapy using psilocybin under a Section 56 Exemption that was granted to a palliative patient by Health Canada. Additional patients who have recently obtained Section 56 Exemptions are also scheduled to undergo legal psychedelic therapy with ATMA next week.

Greg Habstritt, President of ATMA, said: "While we remain optimistic that Health Canada will continue to increase access to psychedelic therapy, we're mindful that the timelines are not certain and that it will take some time before mainstream access to this medicine exists."

He suggested that because of this, ATMA's business model will allow the generation of immediate revenue and cash flow from more traditional retreat services while the company continues to work within the Health Canada guidelines and regulations.

"We're a bit different in the industry, because we're not building clinics out designed exclusively for psychedelic therapy and then waiting for the legislation to change. We'll be operating profitable Journey Centers immediately, with the ability to introduce and expand a range of psychedelic medicines and related services as they become accessible and legal."

Added Harder: "Today has special meaning to me because this is the realization of a vision that I've held for 5 years to have a special environment in which this medicine work can be done.

The acceleration of awareness and acceptance of psychedelics in the health care and medicine arenas over that time has been extraordinary to witness. In the end, what matters most is that those who are suffering and would benefit from this medicine get access to it as soon as possible."

ABOUT ATMA JOURNEY CENTERS INC.

ATMA is a Canadian company focused on delivering effective and innovative healing and transformative experiences that leverage the potential of psychedelic medicine to awaken the inner healer and allow a deeper connection with self, with others, and with the beauty of our world. ATMA was the first private company in Canada to conduct legal psychedelic-assisted therapy with psilocybin, one of the active hallucinogens found in 'magic mushrooms'. For more information, visit http://www.atmajourney.com.

ATMA Creekside Journey Center accommodations provide ample space for guests to enjoy the tranquility and healing energy of the natural surroundings (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside features a warm and inviting main lodge for guests to gather and share (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside guest accommodations are well appointed and comfortable spaces in which to rest and heal (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside Journey Center in Alberta, Canada's first psychedelic therapy wellness center (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside Journey Center is nestled at the foot of the Rocky Mountains with a creek that runs through the 60 acre forested property (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside Journey Center offers modern conveniences and comfort to maximize the healing and transformational process that guests experience (CNW Group/ATMA Journey Centers Inc)

ATMA Creekside offers 60 acres of private natural sanctuary in which to explore, reflect and reconnect with self (CNW Group/ATMA Journey Centers Inc)

SOURCE ATMA Journey Centers Inc

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ATMA Unveils Canada's First Psychedelic Journey Center, Offering 60 Acres of Immersive Healing and Transformation in the Foothills of the Rocky...

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Psychedelic Partnership Reached, Ehave Inc. and Brain Scientific Sign Memorandum of Understanding to Map Brain Response to Psychedelic Treatment,…

Posted: at 12:19 am

Ehave, Inc. to leverage data and AI to correlate biomarkers for the identification of psychedelic drug administration as a treatment for Chronic pain, Depression (major and persistent), PTSD, Bipolar disorder, General anxiety, ADHD and Schizophrenia

MIAMI, Feb. 17, 2021 (GLOBE NEWSWIRE) -- Ehave, Inc. (OTC Pink: EHVVF) (Ehave or the Company), a provider of digital therapeutics for the psychedelic and mental health sectors, announced today it has entered into a Memorandum of Understanding (MoU) with Brain Scientific Inc. (OTCQB: BRSF) (Brain Scientific) that will allow the two companies to leverage both data and AI to correlate biomarkers for the identification of chronic pain, depression (major and persistent), PTSD, bipolar disorder, general anxiety, ADHD and schizophrenia. The terms of the MoU call for Ehave and Brain Scientific to collaborate to exploit graph based AI, linked data protocols with respect to such AI, and leverage such data and AI to develop neural net algorithms. As an initial matter, one purpose of the neural net algorithm would be to upload already trained neuronet into a specialized chip that Brain Scientific is developing into a temporary E-Tattoo.

As part of the MoU, Ehave would integrate Brain Scientific's NeuroCap and NeuroEEG to acquire data from patients in real time, or put such data into a cloud. Ehave could also seek to deploy NeuroCap and NeuroEEG in clinical settings with Ehaves partner healthcare providers, such as psychiatrists, psychologists, psychotherapists and general practitioners. This will allow Ehave to capture the data around the electrophysiological changes in brain pre, mid and post psychedelic drug administration, and possibly build or partner with a functional lab to be equipped with NeuroCap and NeuroEEG devices to conduct market studies and collect data on various brain related physiological and mental disorders. These market studies and data collection activities are likely to begin in Australia and could be implemented in other parts of the world where Ehave operates. This same functional lab can be used to study consumer behavior and psychology in markets Ehave operates for further commercialization of Ehaves data and technologies.

Brain Scientific is seeking to improve neurology by modernizing the brain diagnostic market with its cutting-edge technology. As part of the MoU, Brain Scientific would provide its proprietary data signal acquisition devices, NeuroCap and NeuroEEG, for the Ehave platform. Brain Scientific will also provide the training and support needed to operate the installed equipment, the necessary software and hardware for the development of the technology and products, and will develop and validate products within three months of receiving any specifications from Ehave.

All data from any transactions contemplated by the MoU will be jointly owned by both Ehave and Brain Scientific. Ehave will cover the cost of testing and certification for products developed under this MoU and will receive full rights to all related intellectual property, including the right to sell and distribute any such products, on a 50/50 split basis after all expenses, including research and development.

The transactions contemplated by the MoU are subject to the negotiation, execution and delivery by the parties of definitive final agreements.

Victor S. Dorodny, MD,ND,PHD,MPH (www.DrDorodny.com), Medical Advisor to Ehave, said This revolutionary technology might discover the mechanism of the dissociative effects of Ketamine. Ketamine actually "brakes" the pathological neuronal associations of the disease, and by doing so resets the normal brain activity."

Alfred Farrington II, CIO @Ehave, Inc. said, The brain data in this platform is being compiled to help mental health researchers and give expertise to help practitioners make more informed decision about mental health care. We believe that data will revolutionize mental health, digitizing and analyzing it will give the health industry the opportunity to learn from this data while providing longitudinal insights that can link brain analysis and psychedelics.

Our current EEG device is about the size of a stamp. By shrinking the technology, the system allows for continuous measurement during a persons normal activities, while providing a non-intrusive way to monitor various disorders, said Boris Goldstein, Chairman of Brain Scientific. We believe the future of EEG testing will be centered around the ability to gather more precise data through non-invasive measures of the brain via 3D temporary imprint or implanted graphene electrodes. By utilizing graphene, which has been called a wonder material of the 21st century, Brain Scientific believes the size of the electrodes can be thinner than a human hair and will allow brain activity monitoring with minimal distraction from everyday life.

Ben Kaplan, CEO of Ehave, Inc. said, "One major goal of biomarker research is to improve the accuracy of diagnosis to improve patient outcomes. Biomarkers are measurable and do not define how a person feels or functions. There are currently 250 biochemical markers measured by assay to provide information about a broad range of the body's organic systems and their state of function, as well as how well the body responds to a treatment for a disease or condition." Mr. Kaplan continued, "This approach has been successful for some disorders, but for psychiatric disorders it still poses challenges. This MoU between Ehave and Brain Scientific could utilize graph based AI and linked data protocols to aid in the development of biomarkers for psychiatric disorders."

Additional Ehave Inc. Information

We are truly grateful for the support of EHVVF shareholders! Please join the conversation on our Ehave supporters telegram group at https://t.me/EhaveInc.

The company posts important information and updates through weekly videos from the official company YouTube channel https://www.youtube.com/channel/UCnyW1mgMd0qmYkEMq3O6FWA.

Please follow Ehave on Twitter @Ehaveinc1

About Ehave, Inc.

Ehave, Inc. (EHVVF) is a leader of digital therapeutics delivering evidence-based therapeutic interventions to patients. Our primary focus is on improving the standard care in therapeutics to prevent or treat brain disorders or diseases through the use of digital therapeutics, independently or together, with medications, devices, and other therapies to optimize patient care and health outcomes. Our main product is the Ehave Telemetry Portal, which is a mental health informatics platform that allows clinicians to make objective and intelligent decisions through data insights. The Ehave Infinity Portal offers a powerful machine learning and artificial intelligence platform with a growing set of advanced tools and applications developed by Ehave and its leading partners. This empowers patients, healthcare providers, and payers to address a wide range of conditions through high quality, safe, and effective data-driven involvement with intelligent and accessible tools. Additional information on Ehave can be found on the Companys website at: http://www.ehave.com.

About Brain Scientific:

Brain Scientific is a commercial-stage healthcare company with two FDA-cleared products, providing next-gen solutions to the neurology market. Its smart diagnostic devices and sensors simplify administration, shorten scan time and cut costs, allowing clinicians to make rapid decisions remotely and bridge the widening gap in access to neurological care. To learn more about Brain Scientifics corporate strategy, devices or for investor relations please visit: http://www.brainscientific.comor email at info@memorymd.com.

Forward-Looking Statement Disclaimer

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements may be preceded by the words intends, may, will, plans, expects, anticipates, projects, predicts, estimates, aims, believes, hopes, potential or similar words. Forward-looking statements are based on certain assumptions and are subject to various known and unknown risks and uncertainties, many of which are beyond the Company's control, and cannot be predicted or quantified and consequently, actual results may differ materially from those expressed or implied by such forward-looking statements: (i) the initiation, timing, progress and results of the Companys research, manufacturing and other development efforts; (ii) the Companys ability to advance its products to successfully complete development and commercialization; (iii) the manufacturing, development, commercialization, and market acceptance of the Companys products; (iv) the lack of sufficient funding to finance the product development and business operations; (v) competitive companies and technologies within the Companys industry and introduction of competing products; (vi) the Companys ability to establish and maintain corporate collaborations; (vii) loss of key management personnel; (viii) the scope of protection the Company is able to establish and maintain for intellectual property rights covering its products and its ability to operate its business without infringing the intellectual property rights of others; (ix) potential failure to comply with applicable health information privacy and security laws and other state and federal privacy and security laws; and (x) the difficulty of predicting actions of the USA FDA and its regulations. All forward-looking statements included in this press release are made only as of the date of this press release. The Company assumes no obligation to update any written or oral forward-looking statement unless required by law. More detailed information about the Company and the risk factors that may affect the realization of forward-looking statements is contained under the heading "Risk Factors" in Ehave, Inc.s Registration Statement on Form F-1 filed with the Securities and Exchange Commission (SEC) on September 24, 2015, as amended, which is available on the SEC's website, http://www.sec.gov.

Ehave Inc

Media Inquiries: Gabe Rodriguez

Gabe@Ehave.com

Investor Relations:

Email: Ir@Ehave.com

Phone: (623) 261-9046

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Psychedelic Partnership Reached, Ehave Inc. and Brain Scientific Sign Memorandum of Understanding to Map Brain Response to Psychedelic Treatment,...

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This is the first image taken by NASAs Perseverance Mars rover. Now the hunt for life begins. – MIT Technology Review

Posted: at 12:17 am

NASAs Perseverance rover has landed safely on Mars. The spacecraft survived its journey through the Martian atmosphere and made a soft touchdown at Jezero crater.Shortly after landing, it sent back this picture from the surface using its Hazard Avoidance Cameras, which it will use when on the move. The image is partially obscured by a dust cover.

What happened: Perseverance began its descent into the Martian atmosphere Thursday afternoon, a process affectionately called the seven minutes of terror. The spacecraft survived scorching temperatures thanks to its heat shield. Its parachute deployed without a hitch, the rover was able to locate and navigate toward a safe landing spot, and the descent apparatus lowered the spacecraft down to the surface. NASA confirmed a successful touchdown at 3:55 p.m. US Eastern time. During its descent, Perseverance went from traveling at 12,000 miles per hour to just 1.7 mph in seven minutes.

Because of the distance between Earth and Mars, communication between NASA mission control and the spacecraft is delayed by 11 minutes. That means the entire landing process had to be accomplished autonomously. Onboard systems tracked the surface for hazards during descent and steered the rover away from any threats.

NASA

Whats it doing on Mars? Perseverances predecessorsSojourner, Spirit, Opportunity, and Curiosityled to compelling revelations of what Mars currently looks like and what it once was. Scientists learned that the planet was once a warm planet teeming with lakes and rivers, and that its home to complex organic matter. Together, these key ingredients suggest Mars could have been habitable to microbial life in the ancient past.

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This is the first image taken by NASAs Perseverance Mars rover. Now the hunt for life begins. - MIT Technology Review

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The Quest to Live on Mars: Could Humans Really Survive? – Interesting Engineering

Posted: at 12:17 am

The challenge of building a settlement on Mars is daunting, but it's beginning to feel less alien every day. While plans to get us there have multiplied as additional nations enter Martian orbit private aerospace firms have also set their eyes on the Red Planet.

The quest to settle Mars is on, but what are the obstacles to building a Martian colony?

NASA's Artemis program will put humans on the surface of the moon for the first time in decades by 2024 with aims to establish sustainable exploration by the end of the 2020s. Much of what the agency learns from living and working on the moon will prepare it for the "next giant leap" of humanity: landing astronauts on Mars.

The Space Launch System (SLS) and Orion are crucial to NASA's aims to explore deep space beyond the moon. While there, astronauts will test novel instruments, tools, and equipment to advance human interests on Mars. It's here the agency will unfold new human habitats, technologies, and life support systems to inform the pursuit of building self-sustaining outposts far away from Earth.

Sometime in the future, NASA plans to send humans to Mars. But for now, the agency is still in the preparation stage sending robotic exploration missions like the Perseverance rover to develop the technology to sustain a human presence on the Red Planet.

CEO and Founder of SpaceX Elon Musk aims to use the Starship rocket to launch what are easily the most ambitious plans for colonizing Mars. He wants his company to mass-produce Starship which is designed to ferry up to 100 people.

"Building 100 Starships/year gets to 1,000 in 10 years or 100 megatons/year or maybe around 100k people per Earth-Mars orbital sync," tweeted Musk. And by "orbital sync," he means the period during which Earth and Mars are nearly aligned, with a minimum transit time.

In other words, Musk envisions unspeakably large fleets of Starships departing in these periods every 26 months. "Loading the Mars fleet into Earth orbit, then 1,000 ships depart over ~30 days every 26 months. Battlestar Galactica..." added Musk in another tweet. The ideal operational life for Starships would be 20 to 30 years.

The goal, of course, is to build a gigantic colony on Mars and effectively turn humanity into a multiplanet species. According to Musk, this is why he founded SpaceX in 2002, and also why he has raised unconscionable sums of money.

In 2017, Musk claimed his Starship ambitions for Mars could allow a city of one million people on Mars within the next century. A year ago, a Twitter follower of Musk's asked him: "So a million people [on the Red Planet] by 2050?"

Musk's succinct reply: "Yes."

Obviously, this is easier said than done.

However ambitious his plans for Mars, it's not irrational to question the timelines Musk has tweeted. Neither he nor NASA has developed concrete, proven plans of how to build domes on Mars under which humans could breathe and live.

While somewhere near the poles of the Red Planet is the ideal location for building a permanent settlement, SpaceX hasn't announced or possibly even developed the architecture for building a self-sustaining habitat on Mars.

Moving back a step, Starship itself has yet to be tested in outer space (though this could happen later this year), let alone on the moon or Mars. But once there, it should be able to take off without a booster rocket provided enough rocket fuel is stored on Mars (which everyone is still figuring out how to create on the Red Planet).

In 2019, the other tech billionaire and founder of Blue Origin declared his plans to colonize space beginning with the moon.

"We're going to build a road to space," said Bezos during a press conference in Washington, D.C., according to an ABC News report. While the current Amazon CEO wasn't sure how to build them, there are "certain gates, certain precursors" to colonizing space, and Bezos wants Blue Origin to lead.

"It's time to go back to the moon, this time to stay," said Bezos during a long and imprecise monologue about space. But considering the early stage of his aerospace company, it still looks like Blue Origin is trailing behind SpaceX.

The Orbital Assembly Corporation recently announced plans to design and build a habitable "space hotel" in low-Earth orbit with at least two prototypes to simulate generating artificial gravity up to the level one would feel on Mars.

The completed project called Voyager Station will serve as a luxury space hotel, but also as a scientific orbital platform where researchers can experiment and study the effects of sub-nominal gravity on human bodies.

"We have lots of data in zero-G, we have lots of data on 1 G, but what about in between?" asked Shawna Pandya, medical advisor for OAC, rhetorically. "In a seminal 2017 paper fromNaturecalled Artificial Gravity agencies came together to analyze how the human body would react to partial-Earth gravity."

"We offer solutions to these questions in a place that's as convenient as low-Earth orbit," said Pandya.

One day the company of NASA veterans could build a similar platform in orbit of Mars and create a waypoint for weary pilgrims of the Earth-Mars transit. But it still needs to test its concept of robotic construction in space, develop a way to transfer a space station to Mars, or build one from Martian resources.

China recently put a spacecraft in orbit around Mars for the first time called Tianwen-1. The craft will detach a lander, which will attempt a landing on Mars and send a rover out onto the Martian surface.

However, the reason China's government gave for the country's interest in Mars suggests it may have bigger plans for the Red Planet: "If we do not go there now even though we can, then we will be blamed by our descendants," said Ye Peijian, senior aerospace engineer and head of China's lunar exploration program, according toThe Daily Beast. "If others go there, then they will take over, and you will not be able to go even if you want to. This is reason enough."

While China has yet to develop (or perhaps, share) concrete plans to colonize Mars, it seems the concern that other entities or nations could limit the country's ability to do so in the future serves as motivation to try.

Russia has proposed several plans to put humans on Mars from the now-defunct Soviet Union's plans to launch a six-cosmonaut crew to live on Mars for 900 days in 1975, to Russia's 2002 aim to land humans on Mars by 2015, and then another announcement in 2018 with aims for a 2019 landing on the Red Planet.

Despite these repeated announcements and delays, Roscosmos the Russian space agency maintains that Mars is the most preferable planet to colonize. "The studies of the Sun show that it is getting hotter while the temperature on Venus and Mars is growing slowly and this is one of the reasons why Mars looks, perhaps, most preferable today from the prospect of terraforming," said Roscosmos' Executive Director for Long-Term Programs and Science Alexander Bloshenko in a TASS interview.

However, Russia still needs to develop (or share) plans for traveling, landing, and living on Mars before it can think of terraforming. And while it has adamantly disagreed with ideas (like Musk's) about terraforming the Red Planet with nuclear explosions the idea of terraforming itself is still highly theoretical, and could take centuries.

The United Arab Emirates also recently put a spacecraft in orbit around Mars. Called "Hope," it's the first step in a very long-term plan for the Arab nation to recruit and send astronauts to Mars. The mission called Mars 2117 will purportedly involve both Earth-bound and interplanetary steps. But judging from the name of the mission, it will almost certainly not be the first entity to land on Mars.

There are many plans to settle Mars, from nearly every space-faring country and private entity. But the architecture to build a human colony on Mars is still in the very early stages for all of them with SpaceX the sole entity actively performing test launches on a vehicle designed to make a landing. But until a new generation of space-worthy habitats, resource infrastructure, means to generate rocket fuel, and a proven landing vehicle are concrete realities, it's difficult to say for certain when humans will be ready to colonize Mars.

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The Quest to Live on Mars: Could Humans Really Survive? - Interesting Engineering

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Space Foundation Discovery Center hosts Mars Week as NASAs Perseverance rover set to land Thursday – FOX21News.com

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COLORADO SPRINGS Its a journey months in the making and now NASAs Mars rover Perseverance is preparing to land on the red planet, and the Space Foundations Discovery Center is celebrating the event with activities and events for all.

Perseverance rover is set to reach Mars on Feb. 18 around 2 p.m., but that will only be possible if the rover survives what NASAs dubbed the seven minutes of terror.

The last time we sent a rover like Perseverance to Mars was in 2012 when Curiosity landed, Curator for Space Foundations Discovery Center Rachel English said.

Perseverance will have virtually the same landing as Curiosity. But there is only about a 50% chance this landing will be successful. If it is, Perseverance will work to determine whether life ever existed on Mars.

Its going to be doing some incredible work in Jezero crater, where its landing, to search for signs of microbial life on Mars, English added. So itll tell us a lot about the history of Mars as a planet from a geological standpoint, from a climate standpoint, and also, you know, we might find some cool fossils.

Its novel technologies that are enabling the next leaps of exploration: landing with more precision and safely, learn how to make oxygen from CO2 out of the atmosphere and more, NASAs Associate Administrator For Science Thomas Zurbuchen explained.

Whether the mission is successful or not, the Discovery Center is celebrating all week long!

Upcoming Events:

English added, We realize that everyone is getting a little bit of screen fatigue, and we work really hard here at the discovery center to make sure that everything is clean, fun, and safe.

The great part about space exploration is that even if we fail, we still learn.

Failure is one of our greatest teachers as scientists and engineers, so no matter what happens on Thursday, were really excited, English said.

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Why are there so many missions to Mars? – The Economist

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The planet offers hope for the existence of extraterrestrial life, and a chance for countries on Earth to show off

Feb 19th 2021

MARS IS AWASH with alien technology. On February 18th NASAs Perseverance rover landed in a crater called Jezero, near the planets equator, after travelling 470m kilometres over seven months. The United Arab Emirates Hope orbiter has been circling since February 9th. Chinas Tianwen-1 entered the planets orbit a day later, and its lander and rover will attempt to touch down sometime in May or June. There were six operational satellites in orbit when Hope arrived; NASAs Curiosity rover and InSight lander, which arrived in 2012 and 2018, respectively, are also sending back information from the planets surface. Why are there so many Mars missions and what do countries that send them hope to achieve?

In the late 1800s Percival Lowell, an American astronomer, fixed a telescope on Mars and observed a network of long straight lines that he believed to be canals built by an alien civilisation. In the second half of the 20th century, orbiters circling the planet returned far more detailed data about its atmosphere and surface, putting an end to the theory that a race of Martians had existed. But subsequent missions did raise new questions about alien life. They showed that Mars was once more like Earth. Streams, river valleys, basins and deltas on the planets surface suggest there may have been water covering its northern hemisphere. Orbiters, landers and rovers have set out to explore the planets topography and probe its interior for decades in the hopes of revealing whether microbial life might have existed in the pastand whether it still exists today.

There have been roughly 50 years of Mars missions before Perseverance. NASA was the first to land a craft successfully on its surface, in 1976. The latest flurry of activity is down to two things: new opportunities to answer questions about life beyond Earth, and astropolitical grandstanding. Americas rover will study the planets rock record and look for chemical traces of ancient microbial life, whereas the UAEs Hope orbiter will help scientists to understand how gas escapes its atmospherea process that has made Mars cold and dry. Technological advances mean that samples collected by Perseverance could eventually be brought back to Earth, allowing more detailed analysis.

But space exploration is also a matter of prestige and techno-nationalism. Chinas growing space race with its neighbours, India and Japan, which have also sent probes to Mars, reflects their jostling for influence on Earth. The UAE, the space agency of which was founded only in 2014, has crowed that its Hope orbiter is the first interplanetary mission by any Arab country. This posturing is a far cry from the white-hot space rivalry between America and the Soviet Union during the cold war, and there is plenty of collaboration, too: NASA is working with the European Space Agency to retrieve samples collected by Perseverance, for example. But the number of new spacefaring countries reflects a diffusion of wealth, technology and power.

As well as the UAE, lots of other countries have founded space agencies since 2010, including Australia, Mexico, New Zealand, Poland, Portugal, South Africa and Turkey. For now, states have a monopoly on Mars. But billionaires want in, too. Elon Musk, the boss of SpaceX, a private rocketry firm, claims he will launch people to Mars by 2026. Jeff Bezos recently announced that he will step down as the chief executive of Amazon partly to focus on his space venture, Blue Origin. Last month the company successfully tested a rocket designed to carry passengers, although Mr Bezos prefers the idea of floating space colonies to dusty rocks like Mars. One day a trip to Mars may be more about leisure than scientific endeavour. As Perseverance scours the planets surface for clues of ancient life, new life is preparing to set foot.

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Were Still Dreaming of Mars and Martians – The Wall Street Journal

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This afternoon, NASAs Perseverance rover will attempt to land on Mars, making it just the fifth vehicle on a planet about half the diameter of Earth. But compared with the eons of total emptiness until 1997, when NASA landed its first Mars rover, Sojourner, the neighborhood is getting pretty crowded. In fact, Perseverance is the third spacecraft to reach Mars just this month. On Feb. 9, the UAEs Hope Probe arrived in orbit around Mars, where Chinas Tianwen-1 joined it the very next day. In May or June, Tianwen will attempt to land its own rover on the Martian surface, making China the second country to achieve that feat.

The purpose of these missions is to study the composition of Marss soil and atmosphere. The one thing theyre certain not to find is what humanity long dreamed of finding on the red planet: an intelligent species with a civilization and technology comparable to our own. For almost a century, from the 1880s to the 1960s, Martians were humanitys favorite shorthand for extraterrestrial life. Science fiction as a literary genre grew up with Martians, starting with H.G. Wellss 1898 novel The War of the Worlds, about invaders from the red planet. So did the movies, which have used Mars as a showcase for special effects since Thomas Edisons 1910 film A Trip to Mars. Martians were so popular in the early 20th century that the word itself now has a nostalgic feel, conjuring the pasts dream of a future that never came to be.

That humanity would fixate on Martians rather than Venusians or Saturnites wasnt inevitable. Before the rise of modern astronomy, writers who imagined journeys to outer space generally picked the moon as a destinationnaturally enough, since its far more conspicuous than Mars to the naked eye. The earliest such tale is the 2nd-century Greek work A True Story, in which the narrators ship is caught in a whirlwind and carried through the air for seven days and nights until it lands on the moon.

The shift to Mars as the most popular setting for space fantasy began in 1877, when the Italian astronomer Giovanni Schiaparelli published a map of the planet that included features he called canali or channels. Schiaparelli didnt believe these were artificial or carried water, but when canali was translated into English as canals, it was easy for readers to assume that they must be large-scale engineering projectswhich meant that there must be Martians capable of building them.

No one did more to popularize this idea than the American astronomer Percival Lowell, who claimed to have observed even more detailed canal networks. In his 1906 book Mars and Its Canals, he argued that they were built by the inhabitants of Mars to transport water from the polar ice caps. The fact that the canals spanned the whole globe proved that Martians werent divided into warring nations, like us, but knew how to cooperate for the common good: Whether increasing common sense or increasing necessity was the spur that drove the Martians to this eminently sagacious state we cannot say, but it is certain that reached it they have, Lowell wrote.

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Were Still Dreaming of Mars and Martians - The Wall Street Journal

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‘Glitch in the Matrix’ director on simulation theory – Los Angeles Times

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Building his latest documentary around impossibly big questions, a cheeky 90s cyber aesthetic and the words of visionary author Philip K. Dick, director Rodney Ascher explores the labyrinthine terrain between science fiction and reality in A Glitch in the Matrix, tackling an age-old conundrum: Are we living in a simulation?

A genre filmmaker whose natural inquisitiveness lent itself to feature documentaries including 2012s Room 237, about Stanley Kubricks The Shining, and 2015s sleep paralysis exploration The Nightmare Ascher now explores another niche corner of humankinds search for meaning and truth. But as he dove deeper into Matrix, the film took an unexpected turn.

I didnt know that it was going towards horror; I thought it was going towards science fiction, said Ascher, whose film, conceived before the pandemic and completed remotely during it, premiered at this years virtual Sundance Film Festival.

Blending sci-fi cinema and video game iconography, the academic theories of experts such as Oxford philosopher Nick Bostrom and firsthand musings from eyewitnesses who are transformed on screen into otherworldly CG avatars, Matrix explores wide-ranging implications of simulation theory with imaginative, pop culture-infused flair.

In its most chilling and controversial sequence, Matrix employs photogrammetry and eerie computer animation to re-create the 2003 night when teenager Joshua Cooke, obsessed with the 1999 film The Matrix, murdered his parents. The case spawned the Matrix defense, in which a defendant claims they believed they were in a simulation of the real world. Cooke is interviewed in the film from prison, where he is serving a 40-year sentence.

Beaming in via videochat, Ascher discussed the methods and origins of the film and considered the ways it has garnered unexpected relevancy since it first began. The film is now available on VOD and in virtual cinemas.

Were in a world where there are not just disagreements about opinions, but disagreements about facts, he said. And I like to think that this project can be a good entryway into talking about that stuff maybe as a piece of self-examination, wondering, if were all living in our own Platos Caves, how accurate are the shadows that we choose to spend the most time looking at?

A Glitch in the Matrix filmmaker Rodney Ascher in Los Angeles. The film had its world premiere at the first virtual Sundance Film Festival, where audiences attended screenings through their screens due to the pandemic.

(Robert Gauthier/Los Angeles Times)

You made this film before our new pandemic reality set in, but A Glitch in the Matrix uses language that were now all-too accustomed to in our daily lives: Subjects are interviewed over Skype, through screens, and are even presented in avatar form. How prescient does that choice feel now?

It looks like the conversation that were having right now, you and me, but we actually shot the interviews in 2019. Its a very strange coincidence that a movie that is built on these Skype calls, these webcam video calls, is getting released into a world in which were all interacting with each other through these images. In some ways having an avatar speaking to people in these interviews, people speaking in their real world environments, might seem a little bit like a satire of the first few COVID-19 projects that have hit. Or just the way that we live. A very strange coincidence, but not the only one.

Have you experienced instances of dj vu, glitches or synchronicities you cant explain?

Synchronicities, for sure. Even in the course of this film. The name that [Dick] came up with for the day that he had this big revelation in February and March of 1974, he called 2-3-7... 4. [Room 237, Aschers documentary about The Shining, is titled after a motif in the Kubrick film.] Philip K. Dick wrote extensively about Martian colonies, and [Glitch in the Matrix subject] Jesse [Orion] thinks we need to colonize Martian planets in order to get our message out to the creator. And, Elon Musk is working on a Mars colony. All three of them are thinking Mars is the place.

Are you endorsing Elon Musk as a voice of authority on the matter?

Im saying Elon Musk is a Philip K. Dick-esque character. As a globe-trotting outer space executive whos fascinated with the idea of simulation theory, the fact that he, Philip K. Dick and Jesse Orion were all speaking actively of Martian colonization, struck me as significant. His speech gave a lot of people permission, and Jesse talks about it explicitly: If somebody as rich, famous and powerful as [Musk] believes in it, maybe theres something to it.

Had you been thinking about simulation theory for a long time when you began developing Glitch in the Matrix?

One of the people I spoke to for The Nightmare believed in simulation theory. He was the first person who turned me onto the idea that it wasnt just an idea from science fiction movies it wasnt just The Matrix, eXistenZ, The 13th Floor, but that people were taking it seriously and that physicists were trying to see if they could look at the end of the universe and whether it broke down into a particular scale of pixel, and what that meant. That blew my mind. It was the beginning of a rabbit hole that I still havent been able to crawl out of.

A Glitch in the Matrix uses computer animation to visualize the musings and personal stories of its interview subjects.

(Magnolia Pictures)

After making this film do you, in fact, believe that we are in a simulation?

I have no idea. I think I understand Nick Bostroms three-part simulation hypothesis better than I did going in, although I dont necessarily understand whether all three branches are equally weighted. And I dont necessarily understand the bleeding edge of quantum physics and where science comes down on simulation theory, although I do know that people smarter than me, like Neil DeGrasse Tyson and Elon Musk, think of it as plausible.

What I take away from it is more simulation theory as a creation story, as an article of faith: that countless traditions and cultures have stories that explain how we got here, where the universe comes from, and in many ways this could be just another one of them. I was surprised going into this and talking to people, how quickly it became a religious question not just, Is the creator some fifth-grader cramming for their exam over the weekend on another planet or in the future? but, If this is a simulation, what does that mean about our relationship to other people?

Because the first fork in the road is, are we playing Pac-Man where youre the only player and everybody else is a phantom ghost or is this Fortnite, where every character is tethered to a real human being? Where you come in on that fork, whether other people are real too, has extraordinary ramifications for how you live. I see it in the people who mistreat service workers because theyre an obstacle along the way of getting what they want. How that phrase NPC [non-player character] has terrifying connotations of thinking of people that way, and that rippling out, was one of the surprises of this project.

The Joshua Cooke sequence marks a turning point in the film, when hypotheticals collide with real world consequences and go to a very real, horrifying place. How did you measure how much of his story to include, and how to go about it?

In the early days I had a big whiteboard with every idea I could think of related to simulation theory. One of the early ones was the Matrix defense, the fact that people had used simulation theory as part of a criminal defense to explain an insanity defense that they werent liable for their actions because they didnt realize the real world implications; they thought they were living in a simulated reality. I wanted to get something about the Matrix defense into the film, and there was really only one person who used it. [Cookes lawyers at the time considered using the defense; he ultimately pleaded guilty.]

[Producers] Rebecca Evans and Colin Frederick found Joshua, and Joshuas at a place in his life where hes just written a self-published book on Amazon and hes trying to reach kids to try to help prevent them from repeating his mistakes, trying to learn from what he went through and be a better person, work on himself and reach out to kids who are in a similar space. So he was anxious to retell the story. I spoke to him a few times on the phone from an administrators office, but ultimately the recording thats used in the film came from a pay phone in the common area, so you sometimes hear other people in the room a little fight breaks out, you can hear some shouting echoing off the metal walls from time to time.

A scene from A Glitch in the Matrix.

(Magnolia Pictures)

How careful did you decide you should be with that depiction?

Some people have taken exception to that storys inclusion in the film. I get it. Its a pretty troubling sequence in a lot of ways. As I was working on the film, it seemed more and more important to go from abstract speculation to nuts-and-bolts reality, and to especially drill down into some of the real-world consequences of this kind of thinking and the dangers of it. I still find it perfectly fun sometimes to bat simulation theory around and think about some of its implications, but there can be a real danger in disassociating and becoming alienated from reality, and not necessarily believing in the world around you or the people around you... you look around where we are today; people building up false ideas about reality has dangerous consequences all around us, in a thousand different ways.

When it came time to talk about the murder itself and what that was going to look like, I didnt want there to be animated cartoon characters in it in a way that would make it silly. That would be wildly inappropriate even by my standards, which might be looser than other peoples.

The idea of it was not looking at the night through his eyes as he moves through the house as he describes it but more of him 15 years later remembering it and that its a memory thats starting to fray around the edges. Hes narrating it in a very specific, blow-by-blow kind of way, and I think back to The Shining. What frightened me as a kid when I snuck into a screening when I was 13 was the Steadicam that even though this was a bad place, the camera dragged you into it and it almost felt like the floor was so well polished that even if you planted your feet, you would be dragged forward against your will.

The momentum of [animation director] Lorenzo [Fonda]s ghostly camera moving through the rooms, even if you want to put on the brakes, has that kind of eerie, terrifying feeling. And it is a terrifying story. The terror is about making a horrible mistake. Its not about danger happening to you, its about you doing something that you cant undo.

You mention the dangers of people living in false realities today. How have you seen the films themes ripple out into real world events, even after finishing the film?

Clearly the last couple years have shown us the dangers of people creating worlds that, however much theyre at odds with reality, theyre certainly at odds with other peoples realities. Were in a world where there are not just disagreements about opinions, but disagreements about facts. And I like to think that this project can be a good entryway into talking about that stuff maybe as a piece of self-examination, wondering, if were all living in our own Platos Caves, how accurate are the shadows that we choose to spend the most time looking at? Assuming theyre telling us the truth about the world around us. How carefully are we vetting where theyre coming from, or whether they were created in good faith, by journalists working their asses off communicating to us what they find out there, or cynically by folks who are trying to manipulate us to other ends?

There are specific political controversies that that talks about today. But Im perfectly happy for them not to be directly in the film, so that as time goes on you can substitute the next three or four horrifying things that are waiting for us.

An interesting thing about these projects is youre working on them a year, two years, three years before they come out, said Ascher, and you dont know what the worlds going to look like, or how relevant things are going to be.

(Robert Gauthier/Los Angeles Times)

When you set out to find interview subjects for this film, you put out a call online. What kind of responses did you get?

There were maybe 75 or 100 people who wrote us, and I probably talked to 15 or 20 of them at a similar length to the ones who appeared in the film. Its been noted that all four of them are white men, and thats certainly something I noticed in the course of making it. That was also who dominated the replies. I think its fair to ask: Is there something about simulation theory that appeals more to white men?

Its certainly a conversation thats worth continuing to have. Again, its a pretty small sample group so Im not sure if its statistically significant or just the way that it broke in our experience. If the tech world is dominated by white guys, maybe theres something reassuring to them that the creator of the world is more like them. During the [Sundance] Q&A, Paul [Gude] suggested that as a white guy because hes coming from a place of privilege maybe he feels more comfortable sharing this idiosyncratic part of himself than other folks might feel. There might be something to that.

Your film is framed by a Philip K. Dick lecture from 1977 in which he speaks to an audience about his belief in simulation theory. Why was that an important piece of the puzzle for you?

A five-minute version of it that I found on YouTube made me want to include it as a speech thats a milestone in the mainstreaming of simulation theory, and it made me want to find out what else he said. Watching the entire thing, which was 40 or 50 minutes long, was kind of a revelation. I had to watch it two or three times to get my head around it because some of it is pretty complicated, and a little gnarled.

The thing I love about the speech and [why I] included it in the film is that movies based on Philip K. Dick stories even though The Matrix is not one, in many ways it shows his influence helped people understand the idea of simulation theory. Probably Total Recall, more than many of the others. Its been said that the two ideas that he focused on in book to book to book were, What is real? and What is human? Which is also the question of [non-player characters], artificial intelligence and how far away are we from a robot or a computer program that deserves human rights?

And what if... we are those robots?

Exactly. So he was a great figure to consider, as well as the fact that in many ways the audience doesnt seem especially captivated by his speech. They were probably expecting him to talk about his books. But if those ideas sounded kind of crazy in 1977, he was suffering the anxieties of a rising authoritative police state and of loss of privacy and of information out of control, and the idea that we may be in a false world. He seems to have been suffering from neuroses and fears that are so much more common today like he was patient zero of the 21st century existential crisis.

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'Glitch in the Matrix' director on simulation theory - Los Angeles Times

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