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Daily Archives: January 25, 2021
Earth Has Stayed Habitable for Billions of Years. Exactly How Lucky Did We Get? – Singularity Hub
Posted: January 25, 2021 at 4:48 am
It took evolution three or four billion years to produce Homo sapiens. If the climate had completely failed just once in that time, then evolution would have come to a crashing halt and we would not be here now. So to understand how we came to exist on planet Earth, well need to know how Earth managed to stay fit for life for billions of years.
This is not a trivial problem. Current global warming shows us that the climate can change considerably over the course of even a few centuries. Over geological timescales, it is even easier to change climate. Calculations show that there is the potential for Earths climate to deteriorate to temperatures below freezing or above boiling in just a few million years.
We also know that the sun has become 30 percent more luminous since life first evolved. In theory, this should have caused the oceans to boil away by now, given that they were not generally frozen on the early Earth. This is known as the faint young sun paradox. Yet, somehow, this habitability puzzle was solved.
Scientists have come up with two main theories. The first is that the Earth could possess something like a thermostata feedback mechanism (or mechanisms) that prevents the climate ever wandering to fatal temperatures.
The second is that, out of a large number of planets, perhaps some just make it through by luck, and Earth is one of those. This second scenario is made more plausible by the discoveries in recent decades of many planets outside our solar systemso-called exoplanets. Astronomical observations of distant stars tell us that many have planets orbiting them, and that some are of a size and density and orbital distance such that temperatures suitable for life are theoretically possible. It has been estimated that there are at least two billion such candidate planets in our galaxy alone.
Scientists would love to travel to these exoplanets to investigate whether any of them have matched Earths billion years of climate stability. But even the nearest exoplanets, those orbiting the star Proxima Centauri, are more than four light-years away. Observational or experimental evidence is hard to come by.
Instead, I explored the same question through modeling. Using a computer program designed to simulate climate evolution on planets in general (not just Earth), I first generated 100,000 planets, each with a randomly different set of climate feedbacks. Climate feedbacks are processes that can amplify or diminish climate changethink for instance of sea-ice melting in the Arctic, which replaces sunlight-reflecting ice with sunlight-absorbing open sea, which in turn causes more warming and more melting.
In order to investigate how likely each of these diverse planets was to stay habitable over enormous (geological) timescales, I simulated each 100 times. Each time the planet started from a different initial temperature and was exposed to a randomly different set of climate events. These events represent climate-altering factors such as supervolcano eruptions (like Mount Pinatubo but much larger) and asteroid impacts (like the one that killed the dinosaurs). On each of the 100 runs, the planets temperature was tracked until it became too hot or too cold or else had survived for three billion years, at which point it was deemed to have been a possible crucible for intelligent life.
The simulation results give a definite answer to this habitability problem, at least in terms of the importance of feedbacks and luck. It was very rare (in fact, just one time out of 100,000) for a planet to have such strong stabilizing feedbacks that it stayed habitable all 100 times, irrespective of the random climate events. In fact, most planets that stayed habitable at least once did so fewer than 10 times out of 100. On nearly every occasion in the simulation when a planet remained habitable for three billion years, it was partly down to luck. At the same time, luck by itself was shown to be insufficient. Planets that were specially designed to have no feedbacks at all never stayed habitable; random walks, buffeted around by climate events, never lasted the course.
Repeat runs in the simulation were not identical: 1,000 different planets were generated randomly and each run twice. (a) results on first run, (b) results on second run. Green circles show success (stayed habitable for 3 billion years) and black failure. Toby Tyrrell, Author provided
This overall result, that outcomes depend partly on feedbacks and partly on luck, is robust. All sorts of changes to the modeling did not affect it. By implication, Earth must therefore possess some climate-stabilizing feedbacks, but at the same time, good fortune must also have been involved in it staying habitable. If, for instance, an asteroid or solar flare had been slightly larger than it was, or had occurred at a slightly different (more critical) time, we would probably not be here on Earth today. It gives a different perspective on why we are able to look back on Earths remarkable, enormously extended, history of life evolving and diversifying and becoming ever more complex to the point that it gave rise to us.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
Image Credit: PIRO4D from Pixabay
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DEVIN TOWNSEND Shares Details Of Forthcoming Release, The Puzzle – "A Film, Two Albums, And A Graphic Novel Among Other Things" -…
Posted: at 4:48 am
Devin Townsend has checked in with an update on his new project that is currently in the works.
"Over the last 6 months, Ive been working on two 'scores' that have become a film, two albums, and a graphic novel among other things called The Puzzle. Its become a massive project with a lot of great people involved. Its not 'song oriented' and is complicated and abstract. The film has become a tremendous undertaking and we will be streaming it online when it debuts, (along with physical product that is pretty next level).
The concept is meant to describe the last year of chaos and the psychological process it required of us all. The music and visuals act as an analogy for it. The number of people involved (30-40) represents a sort of community amidst it. Theres two albums: Puzzle is chaos and meant to represent the internal dialogue in a fundamentally absurd time, Snuggles is meant to be a beautiful balm that acts as a conclusion and something you can listen to on loop to feel better. Both have a film.
The concept of it all (which Ill explain in YouTube clips pior to the release) is such that I hope it inspires people- if visually inclined- to make their own graphic novels, films, books etc, using the music as a soundtrack. The Puzzle is written to be my version of a soundtrack to a kind of universal experience weve shared, I guess. The movie and books we are producing are meant as examples of the concept... as in: 'everybodys puzzle is unique, based on the same experiences.'
My work has always really just been a product of a compulsion to reflect whats going on in my life. If things are chaotic, its bound to be chaotic. Its been a very bizarre work flow, but its starting to come together now. Delivery date is March 22, release 2-3 months later.
Finally in August, I will be begin recording my next actual album (with songs) for release early 2022. (Untitled so far) but before that, The Puzzle is something very different and really fascinating I think.
Ill be back to podcasts and twitch streams when the workload lightens a touch here. Be well and thanks for everything."
Details have yet to be released, but Sheet Happens Publishing have confirmed that they will release an official guitar transcription book for Devin Townsend's Empath album. A release date has yet to be determined. Watch the official Sheet Happens website here for updates.
Empath was released in March 2019.
Tracklisting:
"Castaway""Genesis""Spirits Will Collide""Evermore""Sprite""Hear Me""Why""Borderlands""Requiem""Singularity Part 1 - Adrift""Singularity Part 2 - I Am I""Singularity Part 3 - There Be Monsters""Singularity Part 4 - Curious Gods""Singularity Part 5 - Silicon Scientists""Singularity Part 6 - Here Comes The Sun"
"Spirits Will Collide" video:
Evermore video:
"Genesis" video:
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Opinion/Hanson: Thoughts on the 1776 Commission and its report – The Providence Journal
Posted: at 4:48 am
By Victor Davis Hanson| The Providence Journal
VictorDavisHanson (authorvdh@gmail.com) is a classicist and historian at the Hoover Institution atStanford University.
The newly formed President's Advisory 1776 Commission just released its report. The group was chaired by Churchill historian and Hillsdale College President Dr. Larry P. Arnn. The vice chair was Dr. Carol M. Swain, a retired professor of political science. (Full disclosure: I was a member of the commission.)
The unanimously approved conclusions focused on the Declaration of Independence, the Constitution, the historical challenges to these founding documents and the need for civic renewal. The 16-member commission was diverse in the widest sense of the familiar adjective. It included historians, lawyers, academics, scholars, authors, former elected officials and past public servants.
Whether because the report was issued by a Donald Trump-appointed commission, or because the conclusions questioned the controversial and flawed New York Times-sponsored 1619 Project, there was almost immediate criticism from the left.
Yet at any other age than the divisive present, the report would not have been seen as controversial.
First, the commission offered a brief survey of the origins of the Declaration of Independence, published in 1776, and the Constitution, signed in 1787. It emphasized how unusual for the age were the founders' commitments to political freedom, personal liberty and the natural equality endowed by our creator all the true beginning of the American experiment.
The commission reminded us that the founders were equally worried about autocracy and chaos. So they drafted checks and balances to protect citizens from both authoritarianism, known so well from the British Crown, and the frenzy of sometimes wild public excess.
The report repeatedly focuses on both the ideals of the American founding and the centuries-long quest to live up to them. It notes the fragility of such a novel experiment in constitutional republicanism, democratic elections and self-government especially during late-18th-century era of war and factionalism.
The report does not whitewash the continuance of many injustices after 1776 and 1787 in particular chattel slavery concentrated in the South, and voting reserved only for free males.
Indeed, the commission explains why and how these wrongs were inconsistent with the letter and spirit of our founding documents. So it was natural that these disconnects would be addressed, even fought over, and continually resolved often over the opposition of powerful interests who sought to reinvent the Declaration and Constitution into something that they were not.
Two of the most widely referenced Americans in the report are Frederick Douglass and Martin Luther King Jr. Both argued, a century apart, for the moral singularity of the U.S. Constitution. Neither wished to replace the founders' visions; both instead demanded that they be fully realized and enforced.
The report details prior ideological and political challenges to the Constitution as we approach America's 250th birthday. Some were abjectly evil, such as the near-century-long insistence that the enslavement of African Americans was legal an amorality that eventually led to more than 600,000 Americans being killed during a Civil War to banish it.
Some ideologies, such as fascism and communism, were easily identifiable as inimical to our principles. Both occasionally won adherents in times of economic depression and social strife before they were defeated and discredited abroad.
Perhaps more controversially, the commission identified other challenges, such as continued racism, progressivism and contemporary identity politics. The report argued how and why all those who insisted that race might become a basis from which to discriminate against entire groups of people were at odds with the logic of the Declaration.
Historically, progressivism assumed that human nature is malleable. With enough money and power, Americans supposedly can be improved to accept more paternalistic government, usually to be run by technocrats. Often they sought to curb the liberties of the individual, under the guise of modernist progress and greater efficiency.
The commission was no more sympathetic to the current popularity of identity politics or reparatory racial discrimination. It argued that the efforts to insist that race, ethnicity, sexual preference and gender define who we are, rather than remain incidental in comparison to our natural and shared humanity, will lead to a dangerous fragmentation of American society.
Finally, the commission offered the unifying remedy of renewed civic education. Specifically, it advocates far more teaching in our schools of the Declaration and the Constitution, and other documents surrounding their creation.
It most certainly did not suggest that civic education and American history ignore or contextualize past national shortcomings. Again, the report argued that our lapses should be envisioned as obstacles to fulfilling the aspirations of our founding.
The commission may be short-lived with the change of administrations, given that it was born in the chaos of the divisive present. President Joe Biden reportedly planned to terminate the commission through an executive order.
But any fair critic can see that the report's unifying message is that we are a people blessed with a singular government and history, that self-critique and moral improvement are innate to the American founding and spirit, and that America never had to be perfect to be both good and far better than the alternatives.
(Victor Davis Hanson was a member of the 1776 Commission. His views here are his own and are not necessarily those of other commission members. The report can be read athttps://www.whitehouse.gov/wp-content/uploads/2021/01/The-Presidents-Advisory-1776-Commission-Final-Report.pdf.)
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Darien Library and Barrett Bookstore welcome author James Rickards and Rob Embers in a discussion about the historic economic crisis due to COVID-19…
Posted: at 4:48 am
Darien Library and Barrett Bookstore welcome author James Rickards and Rob Embers in a discussion about the historic economic crisis that has emerged as a result of the COVID-19 pandemic. This virtual event will take place on Thursday, February 4 at 7 p.m. Register on Darien Librarys website at darienlibrary.org/event/4803.
In his latest book, The New Great Depression, James Rickards pulls back the curtain to reveal the true risks to our financial system and what savvy investors can do to survive even prosper during a time of unrivaled turbulence. Drawing on historical case studies, monetary theory, and behind-the-scenes access to the halls of power, Rickards will shine a clarifying light on the events taking place so investors understand whats really happening and what they can do about it.
About James Rickards
James Rickards is the Editor of Strategic Intelligence a financial newsletter. He is the New York Times bestselling author of The New Great Depression (2021), Aftermath (2019), The Road to Ruin (2016), The New Case for Gold (2016), The Death of Money (2014), and Currency Wars (2011) from Penguin Random House.
He is an investment advisor, lawyer, inventor, and economist, and has held senior positions at Citibank, Long-Term Capital Management, and Caxton Associates. In 1998, he was the principal negotiator of the rescue of LTCM sponsored by the Federal Reserve. His clients include institutional investors and government directorates. He is an op-ed contributor to the Financial Times, Evening Standard, The Telegraph, New York Times, and Washington Post. He has been interviewed by BBC, CNN, NPR, CSPAN, CNBC, Bloomberg, Fox, and The Wall Street Journal.
Mr. Rickards is a guest lecturer in globalization and finance at The Johns Hopkins University, Georgetown University, Trinity College Dublin, The Kellogg School at Northwestern, the U.S. Army War College and the School of Advanced InternationalStudies. He has presented papers on risk at Singularity University, the Applied Physics Laboratory, and the Los Alamos National Laboratory. He is an advisor on capital markets to the U.S. intelligence community, and the Office of the Secretary of Defense, and is on the Advisory Board of the FDD Center on Economic and Financial Power in Washington DC. Mr. Rickards holds an LL.M. (Taxation) from the NYU School of Law; a J.D. from the University of Pennsylvania Law School; an M.A. in international economics from SAIS, and a B.A. (with honors) from Johns Hopkins. He lives in New Hampshire.
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How resiliency forms the strongest link in the digital supply chain – Diginomica
Posted: at 4:48 am
(Image by Kevin Amrulloh from Pixabay )
Recent times have brought the importance of supply chain resiliency into even sharper focus. Organizations that had already built resilience into both their technology networks and operational networks have managed to weathered the turbulent times throughout the COVID-19 pandemic better. For others, it has been a huge wakeup call.
As we now stand back and attempt to regroup, rebuild and regenerate, every business has a chance to reflect and decide how to become better prepared.
This is the point at which organizations in every vertical market should realize that resiliency needs to be built-in at a granular executional level; it is a function that should apply to, and connect with, the architectural foundations of every process in the company. It is not some sort of dial or switch that you simply turn on or up at the start of a crisis, whether it be a global contagion or some other form of economic upheaval.
But before we consider the nature of resiliency, we need to decide what we really mean by "change" itself in order to understand the various forms in which it manifests itself.
At the force majeure level, there is sudden catastrophic change, the likes of which we witnessed in 2020. Outside of pandemics, we should also include other "black swan" events that disrupt supply chains, such as a sunken container ship, a hurricane, or perhaps a widespread contamination incident.
While these massively disruptive and dreadful events typically cause chaos, and even the loss of life, they are comparatively infrequent, and they don't threaten the long-term viability of a business with the same types of market forces and fluctuations that emanate from deeper-set market trends. There are more ground-level changes in demand patterns that nibble away at margins and service capabilities slowly. Less cataclysmic, these changes can ultimately have even more impact than a hurricane.
Even longer term, when securing essential strategic resources for the business itself is threatened, change happens in a form that can lead to business closure. Knowing how and why change itself occurs (and what shape it comes in) can help us to build a resilient supply chain capable of driving business operations today, with a constant eye on every variable factor that could impact business tomorrow.
A resilient supply chain is based on three core capabilities: visibility, intelligence and a digitally connected ecosystem. To restate these cornerstones in more depth, we are talking about:
end-to-end real-time visibility;
intelligence across root cause identification,
exception detection and resolution management;
and an exceptional ability to execute through a digitized ecosystem that provides a path to autonomous "sense and respond" activities.
Taking each of these elements in turn, let's look at visibility. In a traditional business model, an enterprise bases its visibilityonlyon what its suppliers are telling it. You don'treallyknow where your order is, or when it is going to arrive. However, cloud-based supply chain networks offer the opportunity for all parties to view and interact with one single view of an order in real-time. The net result is that the business, its suppliers and its carriers operate using a single instance and version of data - a single source of truth.
This singularity is important. It cuts out uncertainty, delays and eradicates separation so that there is little or no contingency factor in daily operations. But visibility needs to run end-to-end for true clarity. The business needs to know the impact of its actions upstream (on its suppliers) and as far as possible downstream (into its sales channel and customer base).
Additionally, end-to-end visibility needs to happen in real-time, i.e. all of the information relating to all supply chain transactions, movements, price fluctuations and so on, needs to be available all of the time, in real-time. Without real-time, super-high data quality, it is not possible to drive the supply chain by exception and take advantage of machine learning (ML) technologies.
As the resilient supply chain company moves forward, it has the advantage of software algorithms that can help to detect events that can cause disruptive issues. It's important to remember that there will always be an element of "operational noise" throughout both the physical and financial supply chain, so the organization will need to qualify just how much noise it can live with in the normal course of business.
At this point, we can then drill down into the root causes behind any single event. When there is a shortage of materials for a production plant, or perhaps a shortfall in the supply of finished materials for a retail store, we need to understand the why-factor behind these events. Knowing the difference between a shortage caused by a shift in market demands, and scarcity resulting from a container ship being stuck in a port, is fundamentally important.
The real intelligence comes from being able to group together different events happening in various locations around an organisation's total global supply chain. If the business can pinpoint the same root cause across multiple operational issues, then it can deliver resolution management more quickly.
An intelligent, resilient supply chain can process thousands of variables and data sources across a single cloud-based platform to help the business navigate forward. Working at speeds far in advance of any human capabilities, a digital supply chain ecosystem helps all parties connect and collaborate over dates, times, shipping orders, financing and so on. When all partners open up the external-facing portions of their own systems accordingly, business decisions happen faster, with improved accuracy and less uncertainty. More problematic is the fact that it is an uncertainty that breeds contingency and cost.
DB Schenker was in the midst of a supply chain transformation when the pandemic hit. So did the visibility they achieved make a difference? As DB Schenker's Joachim Schaut, VP Intercontinental Supply Chain Solutions, told diginomica, without their supply chain transformation efforts, they would not have been able to come to the aid of their customers in the same way:
"Our customers saved a lot of money with solutions, and keeping it at origin, or delaying it in transit and so on, because we had the visibility on the item level. Without us, those companies would not have this in-depth visibility - and not all on one platform. They would have needed ten days, maybe two weeks, to get all the information. Then you still have two weeks of arriving containers and your shops are full, which leads to warehousing solutions at destination - the most expensive thing you can do."
In the immediate future, more and more of the actions we take inside our most resilient digital supply chains will be carried out autonomously by intelligent agents and smart algorithms. Our physical and our accompanying financial supply chain networks will reflect the automation intelligence already being applied to manufacturing via Industry 4.0 practices.
If today we stand at automation stage 1.0, then business is set to apply more algorithmic intelligence in the future. A business that knows when and where this intelligence resides is not just smart, it is also resilient. It starts to make decisions based not just on short-term prices, supply availability and market demand, but also on perceived business longevity. The core truth is, building supply chains capable of resiliency to "normal" change will enable businesses to adapt to massive upheavals, if and when we have to adjust to some wildly different "new normal."
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VICTOR DAVIS HANSON: Thoughts on the 1776 Commission and its report – Las Vegas Review-Journal
Posted: at 4:48 am
The newly formed Presidents Advisory 1776 Commission just released its report. The group was chaired by Churchill historian and Hillsdale College President Dr. Larry P. Arnn. The vice chair was Dr. Carol M. Swain, a retired professor of political science. (Full disclosure: I was a member of the commission. The report can be read at whitehouse.gov/wp-content/uploads/2021/01/The-Presidents-Advisory-1776-Commission-Final-Report.pdf.)
The unanimously approved conclusions focused on the Declaration of Independence, the Constitution, the historical challenges to these founding documents and the need for civic renewal. The 16-member commission was diverse in the widest sense of the familiar adjective. It included historians, lawyers, academics, scholars, authors, former elected officials and past public servants.
Whether because the report was issued by a Donald Trump-appointed commission or because the conclusions questioned the controversial and flawed New York Times-sponsored 1619 Project, there was almost immediate criticism from the left.
Yet at any other age than the divisive present, the report would not have been seen as controversial.
First, the commission offered a brief survey of the origins of the Declaration of Independence, published in 1776, and the Constitution, signed in 1787. It emphasized how unusual for the age were the founders commitments to political freedom, personal liberty and the natural equality endowed by our creator all the true beginning of the American experiment.
The commission reminded us that the founders were equally worried about autocracy and chaos. So they drafted checks and balances to protect citizens from both authoritarianism, known so well from the British Crown, and the frenzy of sometimes wild public excess.
The report repeatedly focuses on both the ideals of the American founding and the centuries-long quest to live up to them. It notes the fragility of such a novel experiment in constitutional republicanism, democratic elections and self-government especially during the late-18th-century era of war and factionalism.
The report does not whitewash the continuance of many injustices after 1776 and 1787 in particular chattel slavery concentrated in the South and voting reserved only for free males.
Indeed, the commission explains why and how these wrongs were inconsistent with the letter and spirit of our founding documents. So it was natural that these disconnects would be addressed, even fought over, and continually resolved often over the opposition of powerful interests who sought to reinvent the Declaration of Independence and Constitution into something that they were not.
Two of the most widely referenced Americans in the report are Frederick Douglas and Martin Luther King Jr. Both argued, a century apart, for the moral singularity of the U.S. Constitution. Neither wished to replace the founders visions; both instead demanded that they be fully realized and enforced.
The report details prior ideological and political challenges to the Constitution as we approach Americas 250th birthday. Some were abjectly evil, such as the near-century-long insistence that the enslavement of African Americans was legal an amorality that eventually led to more than 600,000 Americans being killed during a Civil War to banish it.
Some ideologies, such as fascism and communism, were easily identifiable as inimical to our principles. Both occasionally won adherents in times of economic depression and social strife before they were defeated and discredited abroad.
Perhaps more controversially, the commission identified other challenges, such as continued racism, progressivism and contemporary identity politics. The report argued how and why all those who insisted that race might become a basis from which to discriminate against entire groups of people were at odds with the logic of the Declaration of Independence.
Historically, progressivism assumed that human nature is malleable. With enough money and power, Americans supposedly can be improved to accept more paternalistic government, usually to be run by technocrats. Often they sought to curb the liberties of the individual under the guise of modernist progress and greater efficiency.
The commission was no more sympathetic to the current popularity of identity politics or reparatory racial discrimination. It argued that the efforts to insist that race, ethnicity, sexual preference and gender define who we are, rather than remain incidental in comparison to our natural and shared humanity, will lead to a dangerous fragmentation of American society.
Finally, the commission offered the unifying remedy of renewed civic education. Specifically, it advocates far more teaching in our schools of the Declaration of Independence, the Constitution and other documents surrounding their creation.
It most certainly did not suggest that civic education and American history ignore or contextualize past national shortcomings. Again, the report argued that our lapses should be envisioned as obstacles to fulfilling the aspirations of our founding.
The commission may be short-lived with the change of administrations, given that it was born in the chaos of the divisive present.
But any fair critic can see that the reports unifying message is that we are a people blessed with a singular government and history, that self-critique and moral improvement are innate to the American founding and spirit, and that America never had to be perfect to be both good and far better than the alternatives.
Victor Davis Hanson is a classicist and historian at Stanfords Hoover Institution and the author of The Second World Wars: How the First Global Conflict Was Fought and Won, from Basic Books. You can reach him via email at authorvdh@gmail.com
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Ordered by God Stephen Hawkings creation theory unravelled in Vatican visit with Pope – Daily Express
Posted: at 4:48 am
Stephen Hawking's predictions in 2010 on colonizing Mars
Professor Hawkingwas a theoretical physicist, cosmologist, and author who was the director of research at theUniversity of Cambridge's Centre for Theoretical Cosmology before he passed away. His incredible work included a collaboration with Roger Penrose on gravitational singularity theorems in the framework of general relativity,and the theoretical prediction that black holes emit radiation, often called Hawking radiation. He was the first to set out a theory of cosmology, explained by a union of the general theory of relativity and quantum mechanics. But he also spent his career tussling with religious views.
In his final book Brief Answers to Big Questions, Prof Hawking concluded there was no possibility of a God.
He wrote: "I think the universe was spontaneously created out of nothing, according to the laws of science.
"If you accept, as I do, that the laws of nature are fixed, then it doesn't take long to ask 'what role is there for God?'"
Histheory had been moulded over the years.
Prof Hawking was a vocal supporter of the Big Bang theory the idea that the universe exploded suddenly out of an ultra-densesingularity smaller than an atom.
To Prof Hawking and many like-minded scientists, the combined laws of gravity, relativity, quantum physics and a few other rules could explain everything that ever happened or ever will happen in our known universe.
However, the genius noted that you could say the laws are the work of God, but that is more a definition of God than a proof of his existence.
In 2007, Prof Hawking described himself as not religious in the normal sense.
He added: I believe the universe is governed by the laws of science.
The laws may have been decreed by God, but God does not intervene to break the laws.
READ MORE:Big Bang breakthrough: Origin of life 'solved' by Soviet scientist in lost Cold War paper
In 2010, Pope Benedict XVI seemed to refer to Hawking, saying, Scientists do not create the world, they learn about it and attempt to imitate it.
Prof Hawking visited the Vatican numerous times due to his involvement in the Pontifical Academy of Sciences, which fosters interaction between faith and reason and encouraging dialogue between science and spiritual, cultural, philosophical and religious values.
He gave a talk on The Origin of the Universein2016where he met with religious leaders, including Pope Benedict XVI and Pope Francis.
Prof Hawking cleared up his view stating that a God was not necessary to spark the Big Bang.
He and co-author Leonard Mlodinow put forward in their book 2010, The Grand Design, that the Big Bang was inevitable.
It reads: "Because there is a law such as gravity, the universe can and will create itself from nothing.
Spontaneous creation is the reason there is something rather than nothing, why the universe exists, why we exist. It is not necessary to invoke God to light the blue touch paper and set the universe going.
However, he did not completely rule out the possibility of the Almighty at the time.
When discussing the book, he told ABC News: One cant prove that God doesnt exist.
But science makes God unnecessary. The laws of physics can explain the universe without the need for a creator.
He also detailed his thoughts on a possible afterlife, stating: I believe the simplest explanation is, there is no God.
"No one created the universe and no one directs our fate.
"This leads me to a profoundrealisationthat there probably is no heaven and no afterlife either.
"We have this one life to appreciate the grand design of the universe and for that, I am extremely grateful.
In 2014, Professor Hawking gave an interview withEl Mundo, where he appeared to explain why so many people follow a religion.
He then declared himself an outright atheist.
He said: Before we understand science, it is natural to believe that God created the universe.
"But now science offers a more convincing explanation.
"What I meant by we would know the mind of God is, we would know everything that God would know, if there were a God, which there isnt. Im an atheist.
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Psychedelics as therapy – The Week
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Research shows that hallucinogens can be highly effective treatments for anxiety, depression, addiction, and trauma. Here's everything you need to know:
Aren't psychedelic drugs illegal?Under federal and most states' laws, they are, but a push to legalize or decriminalize the drugs is gaining momentum. On Election Day, Oregon voters made their state the first to legalize the active ingredient in "magic mushrooms" psilocybin for mental health therapy in a controlled setting with a therapist. Washington, D.C., voters passed Initiative 81, making the city at least the fifth to decriminalize magic mushrooms. Similar legislation has been proposed in California, Vermont, and Iowa. Last summer, Canada issued four terminally ill patients exemptions to take psilocybin for end-of-life anxiety and depression. British Columbia resident Mona Strelaeff, 67, got an exemption for treatment for trauma, addiction, depression, and anxiety. "All the unresolved trauma," Strelaeff said, "it came back and I was beyond terrified, shaking uncontrollably, and crying." She said that psilocybin therapy helped her conquer "those tough memories" and today she "ain't afraid of jack (s---)."
How does psychedelic therapy work?Participants usually take psilocybin or LSD in a relaxing setting, lying down with blindfolds and headphones on, listening to music. Trained supervisors encourage them to "go inward and to kind of experience whatever is going to come up," said Alan Davis, who studies psychedelics at Johns Hopkins University. Bad psilocybin trips are rare Johns Hopkins and NYU researchers conducted 500 sessions without observing any "serious adverse effects" but they can occur. Advocates say careful dose control, supervision, and controlled settings are very important. Psilocybin sessions typically last between four and six hours, while LSD sessions go on for 12. Robin Carhart-Harris, who runs the Centre for Psychedelic Research at Imperial College in London, theorized that such sessions can "reboot" the brain in a way similar to a near-death or intense spiritual experience.
What's the neuroscience?Psychedelics have been shown to stimulate new brain cell growth and create more complex connections that enable various far-flung areas of the brain to communicate with one another. Habitual, rigid patterns of thinking are broken. At the same time, these drugs temporarily dissolve the ego the sense of separation of the self from everything else and produce an "oceanic" feeling of oneness with the universe, which is why many indigenous societies have used them in spiritual practices. "I didn't know where I ended and my surroundings began," one patient told Michael Pollan, author of a book on psychedelic therapy, How to Change Your Mind.
Why does the ego disappear?Experiments have shown that psychedelics diminish blood flow and oxygen consumption in an area of the brain called the default mode network, or DMN. The DMN, which scientists have nicknamed the "me network," acts as a gatekeeper for consciousness, filtering out information so that the brain can operate more efficiently. As the DMN gets turned off, people experience a sudden opening of the gates of perception, ideas, and visions, with vivid hallucinations that give participants new insights into themselves and into life itself.
What are the benefits?Researchers say they can be profound and wide-ranging. One 2014 Johns Hopkins study found that 80 percent of smokers who underwent psilocybin-assisted therapy reported that they remained smoke-free six months afterward. "The universe was so great, and there were so many things you could do and see in it that killing yourself seemed like a dumb idea," one smoker told Pollan. A 2016 study reported that 83 percent of cancer patients with depression and anxiety enjoyed profound increases in life satisfaction or well-being from a single psilocybin dose. About two-thirds of study participants ranked the therapy among the "top five spiritually significant" events in their lives. One professed atheist recalled feeling "bathed in God's love." Fear of death often disappears.
Why are these drugs illegal? During the 1950s, some psychologists thought psychedelics could revolutionize mental health treatment. But when recreational use of these powerful substances became popular among hippies in the 1960s, it sparked a backlash, with tales of bad trips and psychotic breaks. In 1965, the federal government banned psychedelic drugs, and the companies stopped producing them for research. Timothy Leary, the rebel psychologist who encouraged youngsters to "turn on, tune in, and drop out," was branded "the most dangerous man in America" by President Richard Nixon. But after decades of underground use, research into their value has experienced a renaissance. In 2018, the FDA designated psilocybin as a "breakthrough therapy" for depression and anxiety. A year later, Johns Hopkins University launched the Center for Psychedelic and Consciousness Research the same year that Imperial College in London launched its center. "The hoary '60s platitude that psychedelics would help unlock the secrets of consciousness," Pollan says, "may turn out not to be so preposterous after all."
Studying MDMA and DMTOther psychedelics besides LSD and psilocybin have shown therapeutic promise. MDMA, long known as the club drug "ecstasy," or "molly," interacts with many of the same neurotransmitters in the brain as conventional anxiety drugs. Studies show it inspires feelings of "empathy and bonding" that can be incorporated into everyday life with the help of a therapist. Researchers at the Santa Cruz, Californiabased Multidisciplinary Association for Psychedelic Studies have already concluded Phase 2 trials of MDMA-assisted psychotherapy for use in treating PTSD, and are planning Phase 3 trials. Studies have found that ayahuasca, a psychoactive brew of several plants from the Amazon, can also have beneficial effects. Imperial College is studying how DMT, or dimethyltryptamine, known as the "spirit molecule," can help patients suffering from depression and anxiety. During the very intense 20-minute sessions on the drug, "[patients] kind of go on a journey into themselves," said Dr. Carol Routledge. "Sometimes it can be a bit traumatic." Painful, repressed memories and their connection to current problems can be revealed. Routledge and other therapists strongly advise against experimenting with psychedelic substances outside of a controlled setting, warning that the experiences can be overwhelming.
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BetterLife Pharma Is Developing Second Generation Psychedelics: Drugs That Leave Out The Trip – Forbes
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In a recent acquisition, BetterLife Pharma obtained a patented process to produce BOL-148, a ... [+] non-hallucinogenic derivative of lysergic acid that does not require the use of a scheduled substance.
An increasing number of studies are showing the potential benefits of psychedelics, and while their results may be positive, a fact remains: no matter how much support this novel therapy may gain, some people will simply never be interested in the tripping part of a psychedelic experience.
As such, some companies in the space have focused on developing compounds that eliminate the mirages, kaleidoscopic visuals and sometimes unpleasant psychomimetic effects that come with the consumption of drugs like psilocybin mushrooms and LSD.
BetterLife Pharma is one biotech company developing and hoping to manufacture and commercialize drugs that check this box. The company refers to these compounds as second generation psychedelics.
Second generation psychedelics are compounds that have some of the therapeutic effects of psychedelics, without the hallucination, says CEO Ahmed Doroudian. If you wanted to summarize in one sentence, its this: these compounds may have the anti-depressive or anti-anxiety and other effects of psychedelics, without the trip.
The need for this type of drug, Doroudian says, is two-fold: first, to fulfill the need of the patient, who may not be keen on a psychedelic trip, and second, to ease the stress on a medical system not equipped to work with hallucinogenic compounds.
In the clinical sense, if youre a patient and you are using LSD or LSD-type compounds, youre going to need a therapist, a doctor, observing you at the time. We envision, after clinical trials, that our compound would be dispensed by a pharmacist and you could take it at home, he says. Its an outpatient administration of a drug that you could safely use at home to treat your anxiety and depression.
In December, the drug development company acquired Transcend Biodynamics, another biotech firm with a robust IP portfolio focusing on next-gen psychedelic compounds, peptides, pro-drugs, and nutraceuticals. One drug in their portfolio was of particular interest to BetterLife, says Doroudian.
The drug is called 2-bromo LSD, also known as BOL-148, and is a derivative of lysergic acid first synthesized by Albert Hofmann in 1957. The compound is a non-hallucinogenic analogue of LSD, and has been studied recently for use in patients suffering from cluster headaches. While there is other research on this compound, much of it dates back to the 50s, 60s, and 70s. The CEO says further study of its potential implications and clinical trials are part of the companys plan.
The version of BOL-148 BetterLife has obtained through the Transcend acquisition is referred to as TD-0148A. Doroudian says what separates Transcends version is that the company has a patent to manufacture it that does not require the use of any scheduled substances.
BetterLife Pharma CEO Ahmed Doroudian
Right now, the crux of this thing is that all these other groups, including Project Lucy and Mind Med, are using substances that are scheduled. If you wanted to manufacture 2-bromo LSD or BOL-148, you have to go through a process that requires you to deal with scheduled substances, and that comes with all the regulatory issues, he said.
Transcends process allows for the manufacturing and production of BOL-148 through a process that does not include the handling of any scheduled LSD-related materials or narcotics.
The BetterLife team is currently made up of several longtime executives, many of whom have more than 20 years of experience in pharmaceutical development and biotechnology. Were all clinical people and we do everything through an IND FDA approach, said the CEO.
The company has previously had success bringing an anti-cancer drug to clinical trial, and Doroudian says the team has much experience with the process of taking drugs from development to manufacturing. BetterLife is currently in the process of working with a group that can manufacture the drugs to the companys specs and GMP standards. He says that within the next couple of months the company hopes to have a finished product.
Were taking two paths here, he said. The first is an independent investigator study in the United States. Then were doing a lot of preclinical work to complete a package for an IND filing for sometime in the fall, for the full-blown phase two clinical trials for BOL-148.
To complement the companys recent acquisition, it has recently brought on two specialized executives: Patrick Kroupa as Chief Psychedelic Officer, and Justin Kirkland as Chief Psychedelics Scientist. Doroudian says the company is continuing to expand its team of experts, and as it does, more areas of study will be considered. For now, TD-0148As efficacy for depression will be the focus.
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What Will The Psychedelics Space Look Like In 2021? Experts Weigh In – Yahoo Finance
Posted: at 4:46 am
In 2020, psychedelics took the world by storm.Over two dozen companies in the sector became publicly listed.
The industry grewcloserto federal legalization of the first psychedelic compounds for therapeutic use. With scientific, regulatory and corporate developments becoming daily news, its easy to wonder what 2021 will bring to this burgeoning new space.
By the end of 2021, I expect the conversation about access to therapeutic outcomes using what were previously known as psychedelics to be a global conversation, said Bruce Linton, former CEO and founder ofcannabis giant Canopy Growth (NYSE: CGC).
This conversation has got more points of active discussion occurring right now than the cannabis one had for the first five years, he adds.2021 will bring an abrupt start to a real conversation around psychedelic medicine.
Aside from his cannabis endeavors, Linton is an early investor in the psychedelics space and sits on the board of two public companies: MindMed (NEO:MMED) (OTCQB: MMEDF) and Red Light Holland (CSE:TRIP).
He believes that these new categories of molecules and therapies will be a part of the World Economic Forum conversation at Davos in 2022.
Benzinga spoke to several other professionals in the psychedelicsspaceabout the trends that will define the industry in 2021. Here's what to expect:
"New clinical and R&D initiatives will emerge, investment opportunities will increase, and public acceptance will expand, said Payton Nyquvest, Founder, CEO, and Chair of Numinus (TSXV:NUMI).
MindMed co-CEO JR Rahn expects equity analysts and financial media to declare psychedelicsa new biotech asset class and industry.
Rick Doblin, founder and executive director of the Multidisciplinary Association for Psychedelic Studies (MAPS),says the Veterans Administration will host research on the benefits of MDMA-assisted therapy for PTSD. MAPS will publish the results of the first completed Phase 3 trial for psychedelic-assisted therapy in a major peer-reviewed journal this year. The NGO will also expand research into other mental health conditions such as eating disorders, the viability of group therapy, and effectiveness for psychosomatic conditions.
Strategic Growth
Story continues
We're not seeing consolidation yet,Linton says. The psychedelics industry still needs to go through its formative years to reach the consolidation stage within its life cycle.
One of the central themes of the psychedelics industry in 2021 will be a concentration of resources between peer companies in order to accelerate the regulatory process towards legalization.
It's concentrating scientific, academic, regulatory, finance, all these things, so that you have strong teams for the program that has to work through 2021 to deliver big outcomes for 2022, he adds.
CaaMTech CEO Andrew Chadeayne agrees.
There are so many opportunities in this space that it would be impossible to think anyone would be better off going at it alone, he explains.
Until now, companies have been working to establish their niche contribution to the space," Chadeayne says."It will take collaboration to go from arranging atoms in molecules to administering drugs to patients in a healthcare setting."
New Compounds, New Molecules
Expect to see more emphasis on new patentable compounds,Chadeayne says. There will be more derivatives of naturally occurring molecules with proven benefits, beyond the classic list of psilocybin, LSD and MDMA.
We might even see the first human studies on these new molecules during 2021.
So far, only a few psychedelic compounds have been scientifically evaluated in humans. Different psychedelic drugs could provide advantages depending on the use case," he says. "For example, I think we might see researchers investigating shorter-acting or faster-acting drugs.
Approval in Canada?
Novamind (CSE:NOVA) CEO Yaron Conforti said that Canada will lead the way in opening up regulations that streamline patient access to psychedelic medicines.
Throughout 2020, the Canadian Minister of Health Patty Hajdu granted several exceptions to patients and doctors for the possession and use of psilocybin.
So far, 14 patients and 17 healthcare professionals were allowed to consume psilocybin in a legal setting.
This is being very well received by the Canadian public and we should expect to see a lot more coverage of this in the media which will garner more public support, perpetuating a positive cycle of approvals and access to psychedelic treatments," said Penny White, CEO of NeonMind Biosciences (CSE:NEON)
If the anticipated change to the Special Access Program is made in Canada, Nyquvest says, access may be as straightforward as patients simply needing to find a doctor willing to apply for access to the drug on their behalf.
Investing in Psychedelics
In 2021 I believe we will start seeing further institutional investor support for psychedelic medicine companies in the form of biotech index funds and ETFs covering both psychedelics and the greater mental health space, Rahn says.
The first ETF offering coverage of the psychedelics space is set to launch at the TSX exchange under the symbol PSYK on Jan. 15 by Horizons ETFs Management.
If you're only allowing yourself two investments, said Bruce Linton, I would look at a first one, which has some reasonable compliance with regulations in short-term revenue opportunity.
Companies in this category are trying to generate revenues in the short-term, with the objective of using that cash flow to create more value, in order to acquire or build bigger assets.
These can go from Field Trip (CSE: FTRP) (OTCBB: FTRPF) on clinical to -disclosing my association investment- Red Light Holland, says Linton.
Secondly, I would look at a science-driven agenda that's not stuck on a single molecule or approach. I don't like betting on one number, I like the idea of having a portfolio when I'm going long term.
Linton explained that part of the reason he got involved with MindMed is because of the diversified, platform-driven approach this company is taking into researching psychedelic molecules and treatments.
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What Will The Psychedelics Space Look Like In 2021? Experts Weigh In - Yahoo Finance
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