Daily Archives: November 29, 2020

Divock Origi has gone from unstoppable to invisible – Rousing the Kop

Posted: November 29, 2020 at 6:06 am

Its been quite the fall from grace for Liverpool striker Divock Origi.

Just over a year ago, we were parading the 25-year-old striker as a club legend after his goals helped fire Liverpool to Champions League immortality and it felt as if his Reds career had finally sprung into life.

His goals came on the biggest stage for Liverpool against Everton, Newcastle, Barcelona and Tottenham and it showcased he was deserving of more opportunities in the first team.

Such an unstoppable reign of form forced the clubs hand in tying Origi down to a new lucrative long-term contract at Anfield, and he has failed to kick-on since.

There have been a few forgettable performances during the Belgians five-year spell at Anfield, but few were as poor as the display we witnessed last night.

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What makes Origi stand out is that expectations have been sky-high since he hammered home that all-important winning goal in Madrid on June 1.

His failure to follow that up has hurt Liverpool, but more damage has been done on Origis part whose performances have failed to convince Jurgen Klopp and supporters that he can still have a lasting impact at Anfield.

Against Atalanta, Origi failed to land a single shot nor create a chance for his team. He touched the ball on just 22 occasions which was comfortably the lowest output in the team.

His failure to impact matches when called upon is surprising given how consistent he had become in delivering in the big occasions for his team.

He has clocked up 48 appearances since the European Cup final in Madrid scoring just seven goals in that period.

The quality of a striker is not just explosive play, its about having consistency.

This is something that has been worryingly lacking since Origi sent millions of supporters into raptures following his goalscoring exploits against Spurs.

Right now Origi needs to solve this just like the rest of the team need to respond following such a disheartening performance. When he ticks, Liverpool invariably are a better team.

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Josh is a sports journalist from the south who has previously reported on the Reds both home and away from the press box. His idol is Joel Matip while Madrid 19 to this day still remains a blur to him.

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Plaque Psoriasis Treatment Market to receive overwhelming hike in Revenues by 2026 – Cheshire Media

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This report gives a vital investigation of the Global Plaque Psoriasis Treatment market and the development gauges for the conjecture time frame. This report likewise gives market estimating and figures to the Global Plaque Psoriasis Treatment market.

Some of the players in Plaque Psoriasis Treatment Market are Novartis AG (Switzerland),AbbVie Inc.(U.S),Amgen, Inc. (U.S),Johnson & Johnson (U.S),Eli Lilly and Company (U.S),Celgene Corporation (U.S),Sun Pharmaceuticals Industries Ltd. (India)

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Plaque Psoriasis Treatment Market to receive overwhelming hike in Revenues by 2026 - Cheshire Media

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Psoriasis Treatment Market To Observe Exponential Growth By 2020-2027 | Reports Globe – Cheshire Media

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Fort Collins, Colorado The Psoriasis Treatment Market 2020 Research Report provides information on the market size, share, trends, growth, competitive landscape, challenges and opportunities, revenue, and forecast to 2027. Reports Globe recently incorporated a comprehensive overview of the Psoriasis Treatment market into its extensive database. The Psoriasis Treatment Market report has been aggregated by collecting informative data on various dynamics such as market drivers, restraints, and opportunities.

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Impact of Covid-19 on this Market:

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Market Segments and Sub-segments Covered in the Report are as per below:

Psoriasis Treatment Market Segmentation, By Type

Psoriasis Treatment Market Segmentation, By Applications

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Psoriasis Treatment Market To Observe Exponential Growth By 2020-2027 | Reports Globe - Cheshire Media

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Impact of COVID-19 on Psoriasis Treatment Market 2020 | Size, Growth, Demand, Opportunities & Forecast To 2026 | Sun Pharmaceutical Industries…

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Psoriasis Treatment Marketresearch report is the new statistical data source added byA2Z Market Research.

Psoriasis Treatment Market is growing at a High CAGR during the forecast period 2020-2026. The increasing interest of the individuals in this industry is that the major reason for the expansion of this market.

Psoriasis Treatment Marketresearch is an intelligence report with meticulous efforts undertaken to study the right and valuable information. The data which has been looked upon is done considering both, the existing top players and the upcoming competitors. Business strategies of the key players and the new entering market industries are studied in detail. Well explained SWOT analysis, revenue share and contact information are shared in this report analysis.

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Note In order to provide more accurate market forecast, all our reports will be updated before delivery by considering the impact of COVID-19.

Top Key Players Profiled in this report are:

Sun Pharmaceutical Industries Ltd., Amgen Inc., Novartis AG, LEO Pharma A/S, Eli Lilly and Company, UCB S.A., Johnson and Johnson Services, Inc., CELGENE CORPORATION, Pfizer Inc.,, AbbVie Inc., Merck and Co., Inc..

The key questions answered in this report:

Various factors are responsible for the markets growth trajectory, which are studied at length in the report. In addition, the report lists down the restraints that are posing threat to the global Psoriasis Treatment market. It also gauges the bargaining power of suppliers and buyers, threat from new entrants and product substitute, and the degree of competition prevailing in the market. The influence of the latest government guidelines is also analyzed in detail in the report. It studies the Psoriasis Treatment markets trajectory between forecast periods.

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Global Psoriasis Treatment Market Segmentation:

Market Segmentation: By Type

TNF InhibitorsInterleukinsOthers

Market Segmentation: By Application

Hospital PharmaciesRetail PharmaciesOnline pharmacies

Regions Covered in the Global Psoriasis Treatment Market Report 2020:The Middle East and Africa(GCC Countries and Egypt)North America(the United States, Mexico, and Canada)South America(Brazil etc.)Europe(Turkey, Germany, Russia UK, Italy, France, etc.)Asia-Pacific(Vietnam, China, Malaysia, Japan, Philippines, Korea, Thailand, India, Indonesia, and Australia)

The cost analysis of the Global Psoriasis Treatment Market has been performed while keeping in view manufacturing expenses, labor cost, and raw materials and their market concentration rate, suppliers, and price trend. Other factors such as Supply chain, downstream buyers, and sourcing strategy have been assessed to provide a complete and in-depth view of the market. Buyers of the report will also be exposed to a study on market positioning with factors such as target client, brand strategy, and price strategy taken into consideration.

The report provides insights on the following pointers:

Market Penetration:Comprehensive information on the product portfolios of the top players in the Psoriasis Treatment market.

Product Development/Innovation:Detailed insights on the upcoming technologies, R&D activities, and product launches in the market.

Competitive Assessment: In-depth assessment of the market strategies, geographic and business segments of the leading players in the market.

Market Development:Comprehensive information about emerging markets. This report analyzes the market for various segments across geographies.

Market Diversification:Exhaustive information about new products, untapped geographies, recent developments, and investments in the Psoriasis Treatment market.

Table of Contents

Global Psoriasis Treatment Market Research Report 2020 2026

Chapter 1 Psoriasis Treatment Market Overview

Chapter 2 Global Economic Impact on Industry

Chapter 3 Global Market Competition by Manufacturers

Chapter 4 Global Production, Revenue (Value) by Region

Chapter 5 Global Supply (Production), Consumption, Export, Import by Regions

Chapter 6 Global Production, Revenue (Value), Price Trend by Type

Chapter 7 Global Market Analysis by Application

Chapter 8 Manufacturing Cost Analysis

Chapter 9 Industrial Chain, Sourcing Strategy and Downstream Buyers

Chapter 10 Marketing Strategy Analysis, Distributors/Traders

Chapter 11 Market Effect Factors Analysis

Chapter 12 Global Psoriasis Treatment Market Forecast

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Impact of COVID-19 on Psoriasis Treatment Market 2020 | Size, Growth, Demand, Opportunities & Forecast To 2026 | Sun Pharmaceutical Industries...

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Chronic Plaque Psoriasis Therapeutics Market Research Report: Industrial Chain, Sourcing Strategy and Downstream Buyers with Forecast 2026 – The…

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The Chronic Plaque Psoriasis Therapeutics Market grew in 2019, as compared to 2018, according to our report, Chronic Plaque Psoriasis Therapeutics Market is likely to have subdued growth in 2020 due to weak demand on account of reduced industry spending post Covid-19 outbreak. Further, Chronic Plaque Psoriasis Therapeutics Market will begin picking up momentum gradually from 2021 onwards and grow at a healthy CAGR between 2021-2025

Deep analysis about market status (2016-2019), competition pattern, advantages and disadvantages of products, industry development trends (2019-2025), regional industrial layout characteristics and macroeconomic policies, industrial policy has also been included. From raw materials to downstream buyers of this industry have been analysed scientifically. This report will help you to establish comprehensive overview of the Chronic Plaque Psoriasis Therapeutics Market

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The Chronic Plaque Psoriasis Therapeutics Market is analysed based on product types, major applications and key players

Key product type:ClinicalNon-ClinicalInactive

Key applications:HospitalsAmbulatory Surgical CentersOthers

Key players or companies covered are:AbbvieNovartis InternationalPfizerMerckAstelllas PharmaGlaxoSmithKline

The report provides analysis & data at a regional level (North America, Europe, Asia Pacific, Middle East & Africa , Rest of the world) & Country level (13 key countries The U.S, Canada, Germany, France, UK, Italy, China, Japan, India, Middle East, Africa, South America)

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Key questions answered in the report:1. What is the current size of the Chronic Plaque Psoriasis Therapeutics Market, at a global, regional & country level?2. How is the market segmented, who are the key end user segments?3. What are the key drivers, challenges & trends that is likely to impact businesses in the Chronic Plaque Psoriasis Therapeutics Market?4. What is the likely market forecast & how will be Chronic Plaque Psoriasis Therapeutics Market impacted?5. What is the competitive landscape, who are the key players?6. What are some of the recent M&A, PE / VC deals that have happened in the Chronic Plaque Psoriasis Therapeutics Market?

The report also analysis the impact of COVID 19 based on a scenario-based modelling. This provides a clear view of how has COVID impacted the growth cycle & when is the likely recovery of the industry is expected to pre-covid levels.

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Innovent Announces NMPA Granted New Indication Approval for SULINNO (Adalimumab Injection) in China for the Treatment of Polyarticular Juvenile…

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SAN FRANCISCO and SUZHOU, China, Nov. 23, 2020 /PRNewswire/ -- Innovent Biologics, Inc. (Innovent) (HKEX: 01801), a world-class biopharmaceutical company that develops, manufactures and commercializes high quality medicines for the treatment of cancer, metabolic, autoimmune and other major diseases, today announced that SULINNO (adalimumab injection), a recombinant human anti-TNF- monoclonal antibody drug, has been officially approved by the National Medical Products Administration (NMPA) of China for the treatment of polyarticular juvenile idiopathic arthritis (pJIA), which is the fourth approved indication of SULINNO in China. On September 2, 2020, SULINNO was approved by NMPA for the treatment of rheumatoid arthritis, ankylosing spondylitis and psoriasis.

Juvenile idiopathic arthritis (JIA) is defined as arthritis with an unknown cause lasting at least 6 weeks in children aged 16 years or younger. Arthritis is divided into oligarthritis <5 jointsand polyarthritis. Polyarthritis can be further divided into rheumatoid factor (RF)-negative polyarthritis and RF-positive polyarthritis. It is estimated RF-negative polyarticular JIA affects 1 to 4 per 100,000 children annually. Less commonly, RF-positive polyarticular JIA occurs in an estimated 0.3 to 0.7 per 100,000 children each year. JIA occurs in children at a young age, and is often accompanied by many complications that will lead to high rates of defects, disability and mortality when left untreated, deeply impacting the quality of life in children. Early aggressive therapy leads to improved outcomes and prevents potential disease complications.

Since the launch of adalimumab, it has been approved worldwide for the treatment of seventeen diseases, including rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriasis arthritis, juvenile idiopathic arthritis, crohn's disease (including pediatric crohn's disease), ulcerative colitis, hidradenitis suppurativa, uveitis, etc. The efficacy and safety of adalimumab has been well recognized globally, and adalimumab injection is widely used in the North America and Europe. It has been consistently recommended in multiple diagnostic and therapeutic guidelines for the treatment of these diseases, and its significant efficacy has been universally recognized. SULINNO is adalimumab biosimilar developed by Innovent, and its clinical results were published in the Inaugural Issue of The Lancet Rheumatology in 2019. The launch of SULINNO has provided more Chinese patients with high-quality and relatively affordable adalimumab injection, bringing hope and opportunities to more patients.

Dr. Qian Lei, Senior Director of Medical Sciences and Strategies of Special Diseases of Innovent, stated: "Not only does Juvenile idiopathic arthritic lead to functional impairment and decrease in quality of life and social participation in children, but also places a huge economic burden on their families. The approval of SULINNO will provide a high-quality and accessible treatment option for children with polyarticular idiopathic arthritis in China. We hope that this product will benefit more children with polyarticular idiopathic arthritis and their families, allowing them to receive early treatment with high-quality biological drugs.''

About SULINNO

SULINNO is an adalimumab (Humira) biosimilar and a recombinant human anti-TNF- monoclonal antibody independently developed by Innovent. TNF is a proinflammatory cytokine mainly produced by activated macrophages, natural killer cells and T lymphocytes, which is involved in inflammatory and immune responses. Anti-TNF- antibody can bind to human TNF- monomer or trimer, block TNF- binding to the cellular surface receptor, p55 and p75, and neutralize the cytotoxic effect of TNF-, thereby inhibiting the release of TNF- mediated inflammatory factors and cytokines, the adhesion and infiltration of inflammatory cells, the proliferation of fibroblasts and the activation of osteoclasts.

The results of a complete pre-clinical comparison showed that SULINNO has similar in vitro biological activity (binding activity to target antigen TNF- and neutralizing activity), physicochemical property and pharmacokinetic characteristics to those of Humira. The similarities were also demonstrated in pharmacological and toxicological studies. The head-to-head clinical study comparing SULINNO and Humira conducted in patients with ankylosing spondylitis demonstrated a clinical similarity. The study results were published at Inaugural Issue of The Lancet Rheumatology in 2019.

About Innovent

Inspired by the spirit of "Start with Integrity, Succeed through Action," Innovent's mission is to develop and commercialize high quality biopharmaceutical products that are affordable to ordinary people. Established in 2011, Innovent is committed to developing, manufacturing and commercializing high quality innovative medicines for the treatment of cancer, metabolic, autoimmune and other major diseases. On October 31, 2018, Innovent was listed on the Main Board of the Stock Exchange of Hong Kong Limited with the stock code: 01801.HK.

Since its inception, Innovent has developed a fully-integrated multi-functional platform which includes R&D, CMC (Chemistry, Manufacturing, and Controls), clinical development and commercialization capabilities. Leveraging the platform, the company has built a robust pipeline of 23 valuable assets in the fields of cancer, metabolic, autoimmune diseases and other major therapeutic areas, with 4 products, TYVYT (sintilimab injection), BYVASDA (bevacizumab biosimilar) , SULINNO (adalimumab biosomilar) and HALPRYZA(rituximab biosimilar)on market, 4 assets in Phase III or pivotal clinical trials, and additional 15 molecules in clinical trials. TYVYT (sintilimab injection) has been the only PD-1 inhibitor included in the NRDL since 2019.

Innovent has built an international team of advanced talents in high-end biological drug development and commercialization, including many overseas experts. The company has also entered into strategic collaborations with Eli Lilly, Adimab, Incyte, MD Anderson Cancer Center, Hanmi and other international partners. Innovent strives to work with all relevant parties to help advance China's biopharmaceutical industry, improve drug availability to ordinary people and enhance the quality of the patients' lives. For more information, please visit: http://www.innoventbio.com.

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SOURCE Innovent Biologics

Company Codes: HongKong:1801, OTC-PINK:IVBIY

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Elon Musk has overtaken Bill Gates to become the worlds second richest person – CNBC

Posted: at 6:05 am

Tesla co-founder Elon Musk is now the world's second richest person after he leapfrogged Microsoft billionaire Bill Gates, according to the Bloomberg Billionaire Index, which tracks the wealth of the world's 500 richest people.

The 49-year-old entrepreneur, who is also the co-founder of space exploration firm SpaceX, saw his net worth rise by $7.2 billion to $128 billion on Monday as Tesla shares surged days after the news that the electric car company will be admitted to the S&P 500 index in December.

Musk's net worth has risen by $100.3 billion in 2020, marking the largest increase among those on the Bloomberg Billionaire Index. In January, Musk ranked 35th.

Last week, Musk pushed Facebook CEO Mark Zuckerberg down into fourth position when he claimed the third spot.

The only person ahead of Musk now is Amazon boss Jeff Bezos, who took the top spot from Gates in 2017 and has stayed there since.

The move forces Gates down into third place, marking only the second time in the index's eight-year history that he hasn't been ranked in the top two. However, Gates's net worth of $127.7 billion would be considerably higher if it weren't for his philanthropic endeavors. Since 2006, he has given over $27 billion to the Bill and Melinda Gates Foundation.

This year, those on the Bloomberg index have collectively added 23%, or $1.3 trillion, to their net worth as millions of workers face financial hardship after being laid off by their employers due to the ongoing coronavirus pandemic.

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Elon Musk To Win Award In Germany For His Work In Tesla, SpaceX, Boring Company, and More – Torque News

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Following Mark Zuckerberg and Jeff Bezos, Elon Musk is set to receive the Axel Springer Award. Musk will accept the award on December 1, 2020, at the Axel Springer headquarters in Berlin and the theme of the evening will be An Evening for Elon Musk Mission to Mars. Which is based on Elon Musks goal with his SpaceX venture to make humanity multi-planetary and reach Mars by 2024.

Axel Springer is a German digital publishing house and is the largest such company in Europe. The company has several multimedia news brands, such as Bild, Die Welt, and Fakt, and employs more than 15,000 individuals.

Elon is the fifth winner of the Axel Springer Award, with which the company annually honors outstanding personalities who are innovative in an extraordinary way, who create and change markets and who shape culture while at the same time shouldering their social responsibility. The award recognizes achievements to date and encourages them to develop these further. said the press release in the announcement for the award.

Previous winners of the award are Mark Zukerberg CEO and Cofounder of Facebook; Jeff Bezos CEO and founder of Amazon; Sir Timothy Berners-Lee inventor of the World Wide Web and the language on which it is based HTML and Shoshana Zuboff who is an economist and a critic of big tech and data collection.

At this time there is certainly no one better suited to get this award than Elon Musk. His companys are revolutionizing several industries. Tesla is disrupting the century-old automotive industry both with electrification and autonomy. SpaceX is doing the same for the aerospace world ushering in the era of reusable rockets and with a planned 42,000 strong satellite constellation Musk is working on offering worldwide internet access.

The Boring Company is changing transportation significantly cutting the cost of building tunnels and reimagining how we get from point A to point B with hyperloop. And Neuralink if it becomes successful might be Elon Musks most profound contribution to humanity fighting diseases like Parkinsons, Alzheimer's, dementia, restoring mobility, vision, and hearing loss and ultimately going all the way to creating a high bandwidth interface between our brain and Artificial Intelligence.

As one of the most creative entrepreneurs and most brilliant engineers of the digital age, Elon Musk inspires an entire generation. He combines great visions with the indomitable will to achieve them. With PayPal, SpaceX, and Tesla, Elon Musk has turned entire industries upside down, and his drive is irrepressible. He is motivated by the goal of making life better for humanity. And not in small steps, but by fundamentally turning the way we do things on their head. With incredible success. said Mathias Dpfner, CEO of Axel Springer SE

Elon Musk is set to receive the award in person and following he will hold an interview. The event will be live-streamed and we will keep you posted if any new nuggets come out about his work in Tesla and the plans for the company.

For more information check out: Tesla and Volkswagen Small Cars, Timeline and Price Targets Also, see E-bike From Tesla: Model B Turns Heads and Steers Independently

Tinsae Aregay has been following Tesla and The evolution of the EV space daily for several years. He covers everything about Tesla from the cars to Elon Musk, the energy business, and autonomy. Follow Tinsae on Twitter at @TinsaeAregay for daily Tesla news.

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SpaceX’s Starship will have its first high-altitude test next week – Business Insider – Business Insider

Posted: at 6:05 am

Next week, Elon Musk's space-exploration company SpaceX will take a big step forward in its quest to fly people to Mars.

Musk tweeted on Tuesday that SpaceX's enormous Starship spacecraft which the company eventually wants to use to get humans to Mars will undergo its first high altitude test next week. This follows a successful test firing of the current prototype's engines on Tuesday.

A prototype of SpaceX's Starship spacecraft at the company's facility in Boca Chica, Texas (September 28, 2019). REUTERS/Callaghan O'Hare

According to Musk, in next week's test, the rocket will fly 15 km (50,000 feet) into the air. Previous prototypes have made short hops a few hundred meters into the air. This test flight will be a big step in testing whether the design can withstand the rigors of spaceflight.

Elon Musk said in a follow-up tweet on Wednesday that lots could go wrong in this first high-altitude test. "Lot of things need to go right," the billionaire said. When asked on Twitter what he thought the odds were of Starship landing in one piece, he answered "1-in-3."

There are also more prototypes lined up to be tested should this one fail.

Read more: SpaceX may spend billions to outsource Starlink satellite-dish production, an industry insider says and could lose $2,000 on each one it sells

SpaceX's Starship spacecraft is made up of two sections, the Super Heavy booster and the Starship rocket ship which Musk claims will be able to carry 100 people to Mars at a time. The entire spacecraft stands at 120 metres (394 feet) tall.

There's no specific day confirmed for next week, and as TechCrunch notes, test dates are subject to change.

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SpaceX's Starship will have its first high-altitude test next week - Business Insider - Business Insider

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SpaceX plans for Starship test flight next week, which Elon Musk gives 1-in-3 odds of landing intact – CNBC

Posted: at 6:05 am

SpaceX prototype rocket Starship SN8 stands on the company's launchpad in Boca Chica, Texas before an engine test.

@LabPadre

SpaceX is aiming to launch its latest Starship rocket prototype as early as "next week," CEO Elon Musk said on Tuesday, in what would be the company's most ambitious flight test of the rocket to date.

Musk confirmed that Starship prototype Serial Number 8, or SN8, successfully completed a test firing of its three engines ahead of the flight attempt. This next launch is aiming to reach about 50,000 feet altitude well above the 500 foot flights of the prototype's predecessors SN5 and SN6, which completed flight tests on Aug. 5 and Sept. 3, respectively.

The prototypes are built of stainless steel and represent the first versions of the rocket that Muskunveiled last year. The company is developing Starship with the goal of launching cargo and as many as a 100 people at a time on missions to the Moon and Mars.

SpaceX is aiming to pass several further development milestones with Starship SN8's flight.

"Goals are to test 3 engine ascent, body flaps, transition from main to header tanks & landing flip," Musk said in a tweet.

Asked what he thought about chances of the Starship prototype landing intact after the flight, Musk gave SN8 low odds of complete success on the first try.

"Lot of things need to go right, so maybe 1/3 chance," Musk said.

"But that's why we have SN 9 & SN10," Musk added.

Those later prototypes are already in progress at SpaceX'sgrowing facility in Boca Chica, Texas. While SpaceX's fleet of Falcon 9 and Falcon Heavy rockets are partially reusable, Musk's goal is to make Starship fully reusable envisioning a rocket that is more akin to a commercial airplane, with short turnaround times between flights where the only major cost is fuel.

Musk said that SN9 and SN10 feature "many small improvements," with "major upgrades" planned once SpaceX begins work on prototype SN15.

SpaceX's first Starship prototype under construction near Boca Chica, Texas in 2019.

SpaceX

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SpaceX plans for Starship test flight next week, which Elon Musk gives 1-in-3 odds of landing intact - CNBC

Posted in Elon Musk | Comments Off on SpaceX plans for Starship test flight next week, which Elon Musk gives 1-in-3 odds of landing intact – CNBC