Daily Archives: November 22, 2020

Castor Oil for Hair: The Pros and Cons, According to Experts – MarieClaire.com

Posted: November 22, 2020 at 9:46 pm

Selin AlemdarGetty Images

Why does castor oil sound like something you might dab under the hood of your car to quiet a squeaky timing belt, or something a badass witch might give you to ward off evil spirits trying to come for you when you haven't called for them? I do not know. Castor oil is a yellowish oil pressed from the castor bean whichtwistis not a bean at all but is actually a seed. (Also: If you ever encounter castor "beans" do not eat them, they are poison, thank you. And yes, they are non-toxic when cold-pressed, which is the only way you will likely encounter them, thanks again.) But what castor oil definitely can do is quench dry strands and potentially stimulate healthy hair growth (although not more hair growth). We tapped the experts to get more intel.

If you look at the molecular structure of castor oiland why would you (lol)you'd see that it was a glycerol with a long-chain fatty acid. Why does that matter to you? Fatty acids are very good at nourishing the hair follicles, explains Atlanta-based dermatologist Tiffany L. Clay. The outer layer of the hair shaft is covered in tessellating scale-like structures called cuticles, and when the hair is damaged, those are flayed and flared, which results in both frizz and dullness. "Castor oil can seal and allow the cuticle to lie flatter," continues Clay. Like coconut oil and many other botanical oil, castor oil is very good at this job.

If you'd like to explore this application, Clay recommends warming a a very small amount between your palms and smoothing it along your ends, weekly. Because, buyer beware: Castor oil isn't exactly a lightweight oil. Castor oil is thicc and using too much can leave the hair slick or greasy; some reports even suggest the compound can lead to felting or matting. Another less intense option is finding a hair product that contains castor oil, like a shampoo, conditioner, mask, or serum, and working it into your regular hair care routine.

Organic + Cold-Pressed 100% Castor Oil

$26.00

The Essentials Castor Oil

100% Pure Jamaican Black Castor Oil

$9.99

Organic Lavender Castor Oil

$11.99

Look, the internet will tell you anything you want to hear, and we want to believe it, too. We want it to be true that a relatively inexpensive little oil could make your hair grow Princess Jasmine thick. Unfortunately, we asked science, and science said nah.

"There is some proposed benefit of castor oil with improving penetration of topicals and even hair growth," says Dhaval G. Bhanusali, a New York City-based dermatologist who specializes in hair loss. "That being said, I don't think the scientific evidence is there to make any sizable claims, particularly for stimulating new hairs."

If you think of your scalp like a garden, you'll agree that keeping a garden well-watered and fertilized will yield cuter tomatoes than one that's dusty and untended. So yes, castor oil will keep your scalp hydrated and nourished, and the resulting hairs will be stronger, shinier, and healthier. But there will not be more of them, and that's an important distinction.

That said, the inefficacy of castor oil in stimulating novel hair growth shouldn't leave you discouraged. "When it comes to hair loss, I can't stress enough how important it is to go see a board-certified dermatologist," says Bhanusali. "We now have so many new options and it's much easier to create a comprehensive plan for early hair loss than later in the game."

Jamaican Black Castor Oil Hair Butter

$12.08

Jamaican Black Castor Oil Strengthen & Restore Masque

$13.49

Black Jamaican Castor Oil Shampoo

Haitian Black Castor Oil Scalp Care Conditioner

$22.00

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Leading Diagnostics Companies Join Forces to Establish the Access to Comprehensive Genomic Profiling Coalition (ACGP) – PRNewswire

Posted: at 9:46 pm

WASHINGTON, Nov. 17, 2020 /PRNewswire/ -- Seven leading diagnostics companies andlaboratory service providers have formed the Access to Comprehensive Genomic Profiling Coalition (ACGP). The goal of the organization is to collectively advocate for appropriate broad U.S. health insurance coverage of comprehensive genomic profiling (CGP) for patients living with advanced cancer. The current members of ACGP are Exact Sciences (NASDAQ: EXAS), Foundation Medicine, Illumina (NASDAQ: ILMN), LabCorp (NYSE: LH), QIAGEN (NYSE: QGEN), Roche Diagnostics (SIX: RO, ROG:OTCQX: RHHBY), and Thermo Fisher Scientific (NYSE: TMO).

CGP testingperformed soon after a diagnosis of advanced cancer betterinforms medical management, including treatment decisions and patient care, which can improve clinical outcomes. In advocating for coverage of CGP, ACGP will educate health insurers and other healthcare stakeholders about the clinical utility and economic value of CGP.

CGP tests assess the genomic alterations within a patient's cancer to help physicians make more informed decisions about personalized treatment approaches. Using next-generation sequencing (NGS) with a tissue biopsy or a blood sample, this testing method can detect the four main classes of alterations known to drive cancer growth: base substitutions, insertions and deletions, copy number alterations (CNAs), and rearrangements or fusions. These tests can reveal clinically relevant alterations and biomarkers in the tumor's DNA and RNA. This helps identify patients who could respond to specific targeted therapies and immunotherapy that can be more effective and may have fewer side effects.Healthcare professionals can use CGP to help predict patient benefit across multiple targeted therapies and cancer indications, with benefits in progression-free survival for patients with non-small cell lung cancer (NSCLC) as one example.1

"Cancer is a disease of the genome, not solely the tissue. Tumor profiling hasevolved tremendously in the last decade," said Jim Almas, MD, vice president and national medical director of clinical effectiveness atLabCorp, and the chairman of ACGP. "The manufacturers and laboratories forming the coalition have produced incredible assays to help identify the mutations driving advanced cancers, leading patients to better care through targeted cancer treatments."

Despite evidence of the benefits of this approach, some health insurers still use an outdated framework to evaluate coverage for CGP, creating a disparity in access across patient populations. Many commercial insurance plans do not cover this type of testing, while public or government plans like Medicare do.Limited insurance coverage options may prevent some treating physicians from ordering CGP for their patients.

"There is no question that obstacles to coverage have inhibited physicians from ordering comprehensive genomic profiling," said Almas."Additionally, we believe some clinicians are not aware of the advantages of a comprehensive testing approach and the benefits of one CGP test to provide genomic profiling, detect microsatellite instability and tumor mutational burden, and help physicians identify clinical trials for which patients may be candidates."

To learn more about ACGP, go to http://www.accesstoCGP.com

1: Singal G, Miller PG, Agarwala V, et al. Association of Patient Characteristics and Tumor Genomics With Clinical Outcomes Among Patients With Non-Small Cell Lung Cancer Using a Clinicogenomic Database.JAMA.2019;321(14):1391-1399.

SOURCE Access to Comprehensive Genomic Profiling

http://www.accesstoCGP.com

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At-home medication disposal to address rise in overdoses – Gainesville Sun

Posted: at 9:46 pm

Kathleen Roberts| Guest columnist

Data shows that 128 people die each day from the opioid crisis and now, drug deaths are 13% higher than in the first half of 2019, on average.

COVID-19 has brought challenges to every industry, community and person. The impact on our friends and neighbors dealing with substance misuse is no different. Since the start of the pandemic, and especially with orders to stay at home, we've seen an increase in behavioral health issues across our state as well as at the national level.

Similar to COVID-19, substance misuse is an issue we can address by working together. Traditionally in October, our statewide network of community coalitions partners with law enforcement as part of the DEAs National Prescription Drug Take Back Day. This event provides communities the opportunity to dispose of prescription medications in a safe, convenient and responsible means, while providing us the opportunity to educate the general public about substance misuse.

In October 2019, Florida hosted 219 collection sites, collecting 404,980 pounds of prescription drugs. Across the nation, Americans united to safely dispose of 12,699,456 pounds of medications.

This years Take Back Day looked very different in many communities, but it is still important that we properly dispose of expired medications or those we no longer use or want to ensure they dont end up in the wrong hands. The good news is there are easy ways to do this from the comfort of home.

When youre finished using a prescription medication as directed by your doctor, you should safely dispose of it rather than keep it in your medicine cabinet for future use. One way to do so is to mix household materials like cat litter or old coffee grounds with your unused medications, seal them in an airtight container and dispose of it in your trash can.

You can also visit your local drug take-back center these are often a drop box located at your local law enforcement office but you can find the closest one to you using the Drug Enforcement Agencys Controlled Substance Public Disposal Locations search tool.

Finally, one of our favorite ways: at-home disposal kits. These at-home disposal kits allow us to put unused or unwanted medications in the provided pouch, add water, seal and dispose of the now neutralized medications in the trash.

Through a partnership with the Rx Abuse Leadership Initiative (RALI) of Florida, our network of community coalitions across the state will distribute an additional 65,000 at-home drug disposal kits in the coming weeks and months. This is in addition to the 50,000 at-home disposal kits we announced and distributed earlier this year through our partnership with RALI Florida.

While we all need to prioritize our safe disposal efforts, its also important to evaluate how we are storing medications we still need. As we spend more time at home, go through your medicine cabinets to make sure your prescription medications are in a locked or secure place and always out of the reach of children.

Together, we will get through this global health crisis, and at the same time, we can continue to work together to help create safe, drug-free communities for our children.

Kathleen Roberts is executive director of Community Coalition Alliance, a collaborative of community coalitions around the state of Florida.

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A Genome-Wide Association Study in Early COPD: Identification of One M | COPD – Dove Medical Press

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Ye-Jin Lee,1 SeungHo Choi,2 Sung-Youn Kwon,2 Yunhwan Lee,2 Jung Kyu Lee,3 Eun Young Heo,3 Hee Soon Chung,3,4 Deog Kyeom Kim3,4

1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea; 2Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul 135-984 Korea; 3Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Korea; 4Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea

Correspondence: Deog Kyeom KimDivision of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Boramae-Gil 41, Dongjak-gu, Seoul 156-707, Republic of KoreaTel +82-2-870-3207Fax +82-2-831-0714Email kimdkmd@gmail.com

Background: Identifying the genetic basis of airflow limitation is one of the most interesting issues for understanding chronic obstructive pulmonary disease (COPD) pathophysiology. Several studies have shown that some genetic variants associated with COPD have been identified in genome-wide association study (GWAS), especially in patients with moderate to severe COPD; genetic susceptibility for airflow limitation in the early COPD phase has not been widely studied.Objective: We investigated the genetic variants in early COPD.Methods: The present study analyzed Gene-environment interaction and phenotype (GENIE) cohort that included participants who received health screening examination. The association between single nucleotide polymorphism (SNP) and susceptibility to early COPD (FEV1 predicted 50% and FEV1/FVC < 0.7) was tested.Results: A total of 130 patients with early COPD and 3478 controls (1700 ever smokers and 1778 never smokers) were recruited. When compared with the total controls, certain SNPs (rs2818103, rs875033, rs9354627, rs34552148) on chromosome 6 were included at the top of our list (p= 5.6 10 7 9.6 10 6) although they did not reach genome-wide significance. When compared with the never smoker controls, two SNPs (rs2857210, rs2621419) of the HLA-DQB2 gene class were persistently associated with susceptibility to early COPD.Conclusion: Certain SNPs located on chromosome 6 or the HLA-DQB2 gene were the top-scoring SNPs for the association with susceptibility to early COPD in the Korean GENIE cohort.

Keywords: early chronic obstructive pulmonary disease, genome-wide association study, single nucleotide polymorphism, SNP, HLA-DQ gene

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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