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Daily Archives: July 13, 2020
The Limits of Democrats’ Climate Progress – The New Republic
Posted: July 13, 2020 at 5:18 pm
Thursday morning, the World Meteorological Organization released a report projecting that there is a one in five chance of global temperatures rising by 1.5 degrees Celsius (2.7 degrees Fahrenheit) in the next five years, a line beyond which millions of livelihoods will become unviable and homes uninhabitable. In the midst of a summer that has already seen Siberia on fire, the prediction felt more than plausible.
The day before, a group of Joe Biden and Bernie Sanders advisers focused on projecting unity in the Democratic Party released 110 pages worth of policy recommendations, starting with climate policy. The persistent sit-ins, climate strikes, and insurgent candidate success stories of the past four years seem to have accomplished this much: The policy recommendations contained in this document, like just about every other climate plan to emerge from mainstream nodes of the Democratic Party in the last year, are orders of magnitude more sweeping than anyone, even Sanders, would have thought possible in 2016. Thanks doubtless to the influence of the Sunrise Movements Varshini Prakash, Representative Alexandria Ocasio-Cortez, and other left-leaning members of the unity advisers climate segment, the documents climate goals are ambitious: zeroing out building and power sector emissions by 2030 and 2035, respectively; an embrace of environmental justice principles and targeted investments in this countrys most vulnerable communities; installing 500 million solar panels in five years; the creation of a Cabinet position for emissions reductions. Encouragingly, climate also makes an appearance in the recommendations of the economy and immigration recommendations.
Still, the recommendations for phasing out fossil fuels remain weak. The plan doesnt fully grapple with the crisis now gripping oil and gas companies and the financial sector that supports them. Few international commitments are suggested, leaving the United States to eat up most of the worlds remaining carbon budget.
The plans are better than they were. The plans are not enough. What are the plans for?
Though its ostensibly my job to analyze these kinds of climate plans on their own terms, the whole exercise is starting to feel pretty pointless. Documents like the task force recommendationslike presidential campaign platforms or the House Committee on the Climate Crisis reportreally only indicate where were starting from. So far, all the plans on offer will likely produce warming greater than two degrees Celsius. And thats a relatively rosy scenario.
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Opinion: We need ‘serious progress toward all of our students feeling valued and learning at their full potential’ – BethesdaMagazine.com
Posted: at 5:18 pm
MCPS superintendent calls for greater urgency, purpose in eradicating racism
By Jack Smith
| Published: 2020-07-11 00:49
Most years, I spend the Fourth of July holiday enjoying the company of my family and friends; watching the joy on a grandchilds face during a fireworks display; and reflecting on my whereabouts during the many July 4 holidays Ive experienced.
This year, my social time was distanced; fireworks shows were canceled; and I was thinking of a specific July 4 in Montgomery County history I recently read about the day the last recorded lynching took place not far from where I now sit in Rockville as the superintendent of schools.
Recently, a colleague shared with me that the location of the current MCPS central office building on Hungerford Drive and Mannakee Street is close to the location of the last lynching in our county. I was forwarded an article from The Washington Post that shared the details of this horrible event.
According to the article, on July 4, 1896, a lynch mob of 20 to 30 masked men brutally killed Sidney Randolph, a 28-year-old Black man. Mr. Randolph was accused of killing a 7-year-old white girl.
The article goes on to say that the evidence against Mr. Randolph was circumstantial and conflicting, and that he lacked a motive to commit the crime. Yet, police arrested him and a mob saw fit to hang him from a chestnut tree.
While this horrific lynching occurred more than a century ago, my heart sank and my anger was intense as if it had just happened. My thoughts raced forward in time to the 2020 killings of Ahmaud Arbery and George Floyd.
In the last 124 years, we have traveled to the bottom of the ocean and into space; created the internet; and sequenced the human genome. Yet, as a country, we are still unable to protect, value and respect the life and liberty of Black Americans, specifically Black men.
I believe Montgomery County has made progress toward this goal by being on the forefront of desegregation of schools in the 1950s; by years of equity policies and initiatives in the school system; and by the countys passage of a Racial Equity and Social Justice law in 2019.
However,recent social media posts from students of color in our school system that detail their experiences with racism and bias in our schools are a stark reminder that there is much more work to be done. In some of these posts, students shared allegations of bias, stereotyping and racism at the hands of their peers and, more disturbingly, our staff members.
I am grateful to those who stepped forward to share their painful, personal stories. They help us do the work that must be done.
Many of the experiences highlighted in the social media posts reflect what research has confirmed implicit bias exists across the educational spectrum, including preschool. The research also shows that this bias can contribute to disparities in academic outcomes for students of color.
I have no reason to believe that students and educators in our county are immune. Moreover, we know that public education institutions, including MCPS, have only taught a small fraction of what students should know about the Black experience in the United States, including the barriers that exist to full access and opportunity in education.
The good news is we know that bias can be interrupted and curricula can be enhanced to achieve these goals. The MCPS staff is working to enhance our mandatory equity and cultural proficiency training and practices. Work is underway to integrate cultural proficiency and implicit bias training with effective instructional practice and sound content knowledge into all professional learning experiences.
By changing the experience of our students of color through culturally responsive relationships and expanding learning opportunities, we can truly unleash the potential of our students.
Additionally, we have made significant changes to our elementary and middle school literacy and math curricula. Next, we must work on high school literacy, as well as social studies and other curricula at all levels. Providing curricula that meet the needs of our students and creating equitable access and opportunity across the system must continue to be the priority.
While we have made progress in many areas, we must work with a greater sense of urgency and purpose. I am not naive, but I am committed. We will not be able to eradicate racism overnight.
Based on the story of Sidney Randolph and the aforementioned social media posts, racism and bias have long roots. But I believe we can and must move the needle quickly.
I expect to see serious progress toward all of our students feeling valued and learning at their full potential by the time July 4 arrives next year. We cannot wait another century for change.
Jack Smith is the superintendent of Montgomery County Public Schools.
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Partnerships for Progress: Working with Communities in Sri Lanka to Provide Water and Sanitation – Sri Lanka – ReliefWeb
Posted: at 5:18 pm
Despite recent progress, too many people in Sri Lanka are at risk of being left behind due to a lack of access to water and sanitation.
Thats why the Water Supply and Sanitation Improvement Project (WaSSIP) aims to extend access and improve hygiene behavior for nearly 700,000 people.
Community Based Organizations have been key partners every step of the way.
The coronavirus (COVID-19) pandemichas reinforced the need for safe drinking water, the benefits of sanitation and the importance of good hygiene behaviors at all times. Even in countries that have already made great strides in these areas, providing treated piped water and extending safely managed sanitation to every household is more vital now than ever.
Thats why Sri Lankas Water Supply and Sanitation Improvement Project (WaSSIP) works to extend access to safe drinking water and sanitation, and improved hygiene behavior for nearly 700,000 people in urban, rural and estate areas in seven districts in Sri Lanka. It aims to reach those in danger of being left out of the progress made in recent years and potentially being left even further behind by the pandemics devastating impacts.
WaSSIP is Sri Lankas third project financed by the World Bank since 1998 to provide drinking water and sanitation. It finances new water supply systems, rehabilitation of existing water supply systems, toilets for households and schools, and septage treatment plants.
Community Based Organizations (CBOs) play a key role in delivering this project. In Sri Lanka, the World Bank has worked with CBOs for decades and this experience has shown that when given access to information, and appropriate technical and financial support, CBOs can effectively deliver basic services.
To ensure sustainability, local CBOs are trained to operate and maintain the water supply systems. Each household agrees to pay a tariff that ensures that operation, maintenance and replacement costs can be covered. This allows repairs to be made as soon as something goes wrong.
A database is being developed that shows all the rural water supply systems in the country. This database allows the Department of National Community Water Supply to track the performance of CBOs and provide CBOs with the information and support that they need. A 24-hour call center has been established, where anyone can call or text for advice or to lodge a complaint for CBO-managed water supply systems.
As a trusted part of the social fabric, CBOs are well-equipped to help respond to the COVID-19 pandemic even in remote areas. The residents of Rideepana a small village located in a highland area were under curfew with limited ability to travel. It was a tough situation - financially and practically, with no water to consume on certain days, as one resident put it. However, due to the collaborative work between CBOs, the authorities and a nearby water plant, these villagers can now access clean water with which to wash their hands.
Elsewhere in Sri Lanka, a CBO that oversees a water plant funded through WaSSIP is providing water to households with motors in the areas of Polgahapitiya and Raththandeniya. This was initiated at the request of the District Secretariat for these areas to help minimize the gathering of crowds. Not only has it helped to flatten the potential curve, it has also instilled good sanitary practices amongst the community.
Changing behaviors to encourage improved hygiene practices is a key element of this project. Around 900 hygiene awareness trainings been conducted so far. Over 100,000 people have attended - 64% of them female in rural areas and 80% of them female in estate areas. Messages have been specifically developed and targeted to encourage different types of behaviors. Resources have been provided in local languages to ensure their relevance and effectiveness. And hygiene programs have been rolled out in schools so young people can share what they learned with their friends and families.
Eight schools have also been provided with improved sanitation facilities, including menstrual hygiene facilities the first from a World Bank-funded project in Sri Lanka. Being able to manage their menstruation safely, hygienically, and with confidence and dignity is critical not just for girls health and education, but also for economic development and overall gender equality.
As of June 2020, WaSSIP has:
Completed 42 new rural water supply schemes benefiting 13,538 households (with another 51 under construction)
Completed seven plantation water supply schemes connecting 2493 households (with another seven under construction)
Completed 93 system rehabilitations
Completed 13,362individual toilets (with another 10,119 under construction)
From its inception in 2015 to its closing, WaSSIP will ultimately benefit nearly three-quarters of a million people across the seven districts, including Menaka from Nartakande in the Central Province of Sri Lanka. Menaka is from a family of five, all of whom have suffered from lack of access to clean water. The basic washing and cleaning necessities of her family previously meant an arduous 500-meter walk to collect water. However, thanks a new water plant funded by the World Bank and operated through a CBO - Menaka and her family now have access to clean water to drink, bathe and keep their household clean.
The project demonstrates a successful model of service delivery that can be continued to deliver universal access to water supply and sanitation for Sri Lanka and showcases the importance of partnerships with community organizations.
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COVID-19 and progress in treatments so far; here’s experts view – CNBCTV18
Posted: at 5:18 pm
More than 6 months after the outbreak of the COVID-19 pandemic and over 160 days since India reported its first case, the health regulator has approved the first indigenous drug to treat the disease.
Itolizumab is an injectable that can be used only in hospitals and for moderate and severe cases. A single vial costs Rs 8,000 and the treatment will cost Rs 32,000. This is the fifth drug overall to get the green light and the fourth to receive authorisation for emergency use.
So, here is where we stand in treating the disease. Gilead's patented drug Remdesivir is the only drug so far to undergo well designed clinical trials. It is proven to shorten the recovery time but does not cut mortality more data is awaited.
A well-known, inexpensive steroid called Dexamethasone is the only known drug that cuts mortality as per the data currently available. Clinical trials are still ongoing by a study in the UK has shown that it reduces deaths in ICU patients by one-third.
Hydroxychloroquine, which emerged as one of the early drugs to treat the disease, has been hit by one controversy after another. Studies by the WHO have questioned its benefits. The US has revoked its emergency use authorisation and even India has removed the drug from the protocol to treat severe cases. It is currently used as a prophylactic and to treat mild cases.
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1983 – Issue 131: Youth League Progress Blocked At AGM. – Andy Till
Posted: at 5:18 pm
The progress of youth darts has not always been plain sailing. Alchohol and licensing arrangements seem to have been a major stumbling block:
Respected London boss Roger Nickson seems to have been a driving force behind getting an official youth league established. Roger now runs the popular Darts from The Past Facebook group. Perhaps Darts World will seek his views on the progress of those he strongly supported.
The accompanying piece regarding the alteration of formats to give players more time on the oche is another age-old debate. Here it looks well-intentioned in order that young players could gain more experience.
The coverage given here to the A.G.M of the BDO speaks to the importance of the organisation at that time. Sadly, some of the views displayed seem to foreshadow later difficulties.
It should not be overlooked that until very recently the BDO was the driving force behind youth darts, many counties had volunteers who gave time and money to ensure that young players had a way to learn and progress into the other areas of the game. Senior pros from those areas also often helped out. Wiltshires youth was a fine example of this with Steph Venn, Mark Thompson, Dennis Smith, and others, encouraging and developing a fine batch of players. Occasionally they may have even been visited by Bob Anderson.
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1983 - Issue 131: Youth League Progress Blocked At AGM. - Andy Till
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Court refuses to order Houston to host Texas GOP gathering – Preeceville Progress
Posted: at 5:18 pm
HOUSTON The Texas Supreme Court on Monday upheld Houston's refusal to allow the state Republican convention to hold in-person events in the city due to the coronavirus pandemic.
The court dismissed an appeal of a state district judges denial of a temporary restraining order sought by the state Republican Party. Shortly after the ruling, GOP leaders said they would call a meeting of the party's executive committee to "finalize our path forward." After the Supreme Court's ruling, a state judge in Harris County separately denied the party's request for an injunction allowing the convention to go forward.
The state GOP convention had been scheduled to begin Thursday at Houstons downtown convention centre and was expected to draw thousands of participants.
Houston Mayor Sylvester Turner, a Democrat, said last week that he had directed city lawyers to terminate the contract because he believed the event could not be held safely. He denied that the convention was cancelled due to political differences and cited the potential risk to service workers and first responders if the virus spread through the convention.
The state party sued a day later, alleging the city illegally breached the contract and accusing Turner of shedding "crocodile tears."
"The Party argues it has constitutional rights to hold a convention and engage in electoral activities, and that is unquestionably true," the Supreme Court wrote in its opinion. "But those rights do not allow it to simply commandeer use of the Center."
State District Judge Larry Weiman last week sided with Turner, citing Houston statistics that show major hospitals exceeding their base intensive-care capacity due to an influx of COVID-19 patients.
Texas has set daily records in recent days for the number of COVID-19 deaths and confirmed cases. Top officials in Houston have called for the city to lock back down as area hospitals strain to accommodate an onslaught of patients.
The Texas Medical Association withdrew its sponsorship of the state GOP convention and asked organizers to cancel in-person gatherings. As the virus has surged throughout the state in June and July, Gov. Greg Abbott, the states top Republican, has reversed some business reopenings and broadly required the use of face masks.
State GOP chair James Dickey had insisted that organizers can hold the event safely. Prior to Turners move to cancel the convention, Dickey said the party had planned to institute daily temperature scans, provide masks, and install hand sanitizer stations.
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YMCA fire: Crews making progress on wildfire burning near Caon City – OutThere Colorado
Posted: at 5:18 pm
Firefighters expect to continue making progress Friday containing theYMCA fire that has burned nearly 300 acres southwest of Caon City, theBureau of Land Management said.
Firefighters started to take the upper hand Thursday on the lightning-caused fire.
The fire was 30% contained as of 8 p.m. Thursday. Helicopters continued making bucket drops of water through the day to cool off hot spots and hit spots that were inaccessible by ground crews.
Much of the smoke produced on Thursday was from interior fuels, the BLM said, which kept the fire from growing significantly. Overnight, it had grown from about 100 acres to 268 acres. The fire is currently mapped at 293 acres.
Although containment is increasing, smoke and possibly flames will continue to be visible from Caon City and neighboring areas.
The fire was reported about 3:37 p.m. Wednesday on Bureau of Land Management-Royal Gorge Field Office lands. No structures are threatened, no evacuation orders are planned.
According to the Caon City Area Fire Protection District, the fire was in the area of Temple Canyon.
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Gene therapy innovations: Sarepta and Codiak partner on exosomes – Pharmaceutical Technology
Posted: at 5:16 pm
The global spread of the COVID-19 pandemic and the resulting economic impact and public health burden has highlighted the urgent need for a vaccine to prevent the disease. The challenges associated with rapidly developing and producing a vaccine at a large scale are, however, enormous.
Verdict has conducted a poll to assess the time that could be taken for the approval of a COVID-19 vaccine and its availability to the public.
Analysis of the results shows a high chance for an approved COVID-19 vaccine to be available over the next six months, as opined by a majority 36% of the poll respondents, whereas 28% of the respondents feel it could take six to 12 months for the same.
Less than one-fourth (22%) of the poll respondents opined that the approval and availability of a COVID-19 vaccine could take between 12 and 18 months, while 14% felt that it could take more than 18 months.
The analysis is based on 875 responses received from readers of Verdicts Pharmaceutical Technology site between 18 June and 01 July.
The poll findings are in line with those of another poll conducted by Verdict earlier in April, which found high confidence about the possible development of a COVID-19 vaccine within 12 months.
Research organisations and pharmaceutical companies have joined hands in developing a vaccine against the COVID-19 virus that has affected millions of people.
Existing drugs such as remdesivir have been granted emergency use authorisation (EUA) to treat the disease, meanwhile.
Antimalarial drugs including chloroquine and hydroxychloroquine were also awarded EUA, but later revoked after studies showed that they were ineffective in treating the disease.
In another poll conducted on Pharmaceutical Technology site, Verdict tried to assess readers opinion about who should be given priority access to a COVID-19 vaccine upon licensure.
The poll options included three groups namely those with high-risk such as the elderly and patients with co-morbidities, everyone, and those in high-risk geographies from infection.
A majority 46% of the respondents opined that elderly and people with co-morbidities should be given priority access, followed by 33% who opined that everyone should have the same access to the vaccine.
Prioritising the vaccines accessibility to high-risk geographies is of high importance for just 21% of the respondents.
The analysis is based on 354 responses received between 18 June and 08 July.
Eight vaccines are in phase three/two clinical trials currently, while another 120 are in pre-clinical evaluation, according to the World Health Organization (WHO).
The vaccines that have reached advanced clinical trials include ChAdOx1-S by University of Oxford and AstraZeneca, an adenovirus type 5 vector vaccine by CanSino Biological and Beijing Institute of Biotechnology, mRNA-1273 vaccine by Moderna, and National Institute of Allergy and Infectious Diseases.
Sinopharm is collaborating with the Wuhan Institute of Biological Products and Beijing Institute of Biological Products to develop an inactivated vaccine.
Sinovac is developing an inactivated vaccine with alum and Novavax is developing a full-length recombinant SARS CoV-2 glycoprotein nanoparticle vaccine, while BioNTech, Fosun Pharma, and Pfizer are developing a vaccine based on 3 LNP-mRNAs.
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DNA research aims to take ‘trial and error’ out of depression medication treatment – ABC News
Posted: at 5:16 pm
Cindy Black has spent more than four years out of the past decade in hospital being treated for depression.
There have been several suicide attempts in that time, including one that left her in a coma for over a month.
"You just wish you had not got to that point where you felt like there is no other option," Ms Black said.
"It's not a life when you're at that point. It is just existence."
She tried countless medications over the years, but none of them worked.
That changed in 2018, when her doctor recommended that she take a multi-gene test so that a treatment plan could be guided by her genetic makeup.
As a result, Ms Black was prescribed an antidepressant medication she said had changed her life.
"It has just absolutely changed everything," she said.
"It has brought my overall mood up by 80 to 90 per cent, to a point where I was able to say I am actually really happy.
"I don't think I have ever said that or felt that."
The medication she was prescribed was an old drug which required a strict dietary regime, but Ms Black said it was worth it.
"The benefits of having something that works as opposed to spending another 15 years shuffling around to find something else, is a complete no-brainer," she said.
"If I'd had this knowledge a lot earlier on, things could have been a lot different."
While Ms Black continued to live with depression, her outlook had improved dramatically.
After meeting her partner 18 months ago, the pair got engaged on Valentine's Day and have a baby on the way.
"That has been my ultimate dream, having a family," she said.
"It is unthinkable that, for so long, I did not think that this was going to happen."
The testing Ms Black took to narrow down her search for the right medication which involved a brain scan and a cheek swab is not widely used in mainstream healthcare.
The collected cells are used in a multi-gene test, otherwise known as a pharmacogenomic (PG) test, which surveys around one dozen genes that are known to play a role in metabolism.
The same test will be applied to hundreds of newly-diagnosed patients in WA, NSW and Victoria as part of a study to determine whether first-line medications have a better chance of succeeding if their prescription is guided by the patient's individual genetic make-up.
WA North Metropolitan Health Service psychiatrist Sean Hood said finding the right medication for depressed patients often involved trial and error.
"Most patients, when they get treated [for] depressive disorders, don't get full remission on the first medication they are put on," he said.
"Trialling and looking at different medication therapies can take a lifetime for many patients; it can take many years.
"In the past, it has just been clinical wisdom and therapeutic guessing to find the medicine that is going to be best for that person.
"But this sort of testing hopefully will give us the ability to better target the medications that are going to be suitable for that patient early on.
"I hope this can be a game-changer for the treatment of mainstream depression."
A personalised treatment plan will also be prepared for each of the study's participants, but only half of the plans will be guided by patients' results the rest will be developed following current standard-of-care guidelines.
The treatment plans will be reviewed by a national panel of experts to assess whether patients had significant earlier benefit over those receiving standard care.
Office of Population Health Genomics Director Kristen Nowak said although PG testing had been available for many years and there was growing recognition of its value, it had not been adopted widely for guiding medication choice and dosing.
She said if the study proved successful, it could become standard practice in the treatment of depression and be covered by Medicare.
"Given the time, cost and patient impacts of potentially having to try several medications and the fact PG testing has now come right down in cost and turnaround times we think there is real value in assessing the potential benefits of more personalised care," she said.
"We're hoping that if the evidence in this clinical trial shows us that doing this test early in a person's health journey can be effective for them then we would strongly consider making that more standard practice here in Western Australia and across Australia."
The trial, which was funded by the Commonwealth Government's Medical Research Future Fund, will enrol 550 patients, including 275 from WA.
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The Wilderness of Rare Genetic Diseases and the Parents Navigating It – The New York Times
Posted: at 5:16 pm
A confirmed diagnosis may take time.
Diagnosis represents the first step on this rare disease journey. Sometimes doctors will notice something off about the child during a newborn screening, and a genetic test will identify a known mutation in the DNA. But not all conditions are so quickly detected, and it can take several years for parents to get a confirmed diagnosis.
About half of all children never get that far, according to Marshall Summar, M.D., the director of the Rare Disease Institute at Childrens National Hospital in Washington, D.C. When you sequence someones DNA, you are going to find a lot of changes, Dr. Summar said. Figuring out which change might be the one that is causing it is a tremendous challenge.
Genetic counselors warn parents beforehand that they may not get a definitive answer as to what condition their child could have. They may have to check back each year. Dr. Summar estimates that between five and 10 new rare diseases are described in the scientific literature every week, making it challenging for the medical field to keep up.
Meanwhile, the realization that a child may have a debilitating, lifelong condition weighs heavily. Some parents, particularly mothers, blame themselves, said Lemuel Pelentsov, Ph.D., a nurse who studies the needs of rare disease families at the University of South Australia, in Adelaide. In a 2016 study by Dr. Pelentsov and his colleagues, about 40 percent of the 300 rare parents surveyed reported being treated for depression and an equal number for anxiety. One of the things they do to combat that, he said, is get very invested in the childs disease.
When parents reach out to other parents, they are not simply looking for emotional support or advice. They are rebuilding a social life, one that will revolve around their childs disease. Many rare diseases have their own support groups. Global Genes is an umbrella group that supports 600 disease-specific foundations, as well as parents of children whose diseases are so rare they have no foundation.
We encourage folks to work together, said Kimberly Haugstad, the organizations executive director whose son has a rare form of hemophilia, a condition in which the blood doesnt clot normally. The parent is going to come from such different places in their own walk of life.
Each year, Global Genes hosts a Rare Boot Camp to mentor and teach parents how to set up a nonprofit, create patient registries and fund research. After attending the boot camp, the Van Wyks and other parents founded GACI Global, an organization that connects families affected by GACI, along with medical professionals.
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