Daily Archives: July 8, 2020

Adventure Time: Distant Lands Premiere BMO the Hero – Show Snob

Posted: July 8, 2020 at 3:55 am

Adventure Times: Distant Lands "BMO" - Courtesy of HBO Max

Despite all evidence of the world around them falling apart, most characters in Adventure Time: Distant Lands maintain a contagious enthusiasm. Perhaps more than any does BMO.

The first episode of the four-part HBO Max limited series Adventure Time: Distant Lands centers on the brave little robot. BMOs adventure begins with him on a ship destined to terraforming Mars. And it isnt long before BMO laughs in the face of danger, happily fixing the hole in his ship by welding a Band-Aid over it.

Soon after, he meets another robot in space, one that looks like Plankton from SpongeBob SquarePants condensed into a little ball. BMO names his new friend Olive. Olive, much to BMOs chagrin, zips the ship past its original destination and takes BMO through trippy space travel akin to 2001: A Space Odyssey.

Eventually, BMO crashes on a troubled planet. And even though he loses an arm, he is ecstatic to meet a young rabbit scientist, whom he encourages to think up her own name. She settles on Y5.

Much like Finn the Humans parents in the original series, Y5s parents are dismissive and demeaning. They look down on Y5, and tell her to scrap BMO for parts. But BMOs contagious heroicness leads Y5 to her own coming-of-age story.

Its too simple to characterize BMO as childlike. Throughout Adventure Time, and especially in Adventure Time: Distant Lands, BMO is sanguine in the trials and tribulations of his maturity.

But BMO always makes the adult decision to heed the cry of dangers. So often does he rush into action that it takes the sound of an alarm for Y5 to realize she misses BMO.

With the help of his new friends Y5 and Olive, who plays the Jake the Dog role to BMOs Finn, BMO helps save the planet on numerous occasions. He also has incredible one-liners that make him a 21st century Adam West Batman.

He died as he lived, sucking big time, BMO says, as a villain is sucked into outer space.

And even when BMO is at the depths of despair, with his systems shut off and his hardware scattered and littered in the dangerous jungle pod, he calmly and patiently awaits the good he knows will arrive.

Adventure Times: Distant Lands BMO Courtesy of HBO Max

After helping Y5 stand up to her parents, BMO is saved by his new rabbit friend. They save the day together, and BMO only leaves the planet after the young scientist decrees that all the citizens have to learn how to get along and share the limited remaining resources after the villains took most for themselves.

BMO ponders on his ship how Y5 will probably become Mayor of the planet.

BMO ends the episode on a new, strange planet. He looks to the horizon and finds a young Finn and Jake playing outside their treehouse. Ever the optimist, BMO is excited about this new adventure.

Theres much to admire about Adventure Time: Distant Lands. Obviously, having new Adventure Time content is great. Each episode is an hour-long, even better. But retaining the story, humor, and humanity of the characters is the best.

Which Adventure Time character do you wish had their own special as part of Adventure Time: Distant Lands? Let us know in the comments below!

Adventure Time: Distant Lands Episode 1 is available now on HBO MAX.

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Adventure Time: Distant Lands Premiere BMO the Hero - Show Snob

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NASA, China and the UAE are scheduled to send missions to Mars in July | TheHill – The Hill

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Starting in July the window opens when missions to Mars can be easily sent across the interplanetary gulf. If all goes well, three such missions, mounted by NASA, China and the United Arab Emirates, will depart Earth for the Red Planet. The number of missions, who is launching them and their complexity illustrate the importance Mars has for purveyors of space exploration policy.

NASA Perseverance is currently scheduled to launch somewhere between July 30 and August 15. It will land in the Jezero Crater on Mars on February 18, 2021. Perseverance will roll about the Martian landscape looking for signs of life past and present and collecting rock and soil samples for later pickup and delivery to Earth. The rover will also carry a helicopter drone that is envisioned as the first aircraft to fly in the skies of another world.

Chinas Tianwen-1 is the most complex, consisting of an orbiter, a lander and a rover. The name translates roughly to the quest for heavenly truth. The rover is much smaller than Perseverance and contains six scientific instruments. While the rover spends 90 Martian days rolling about studying Mars at close range, the orbiter will examine it from a wider perspective for about a Martian year, serving as a communication relay.

The United Arab Emirates mission is a small orbiter called Hope. Hope is scheduled to launch on a Japanese rocket and will spend 200 days cruising to Mars. The probe will enter an elliptical orbit around the Red Planet. Hope will spend at least two years studying aspects of the Martian atmosphere.

Why are so many missions being sent to Mars in a single month? The answer is different for each player.

NASAs primary mandate since its beginning has been to explore space. The space agency has been sending robot probes to Mars since the Mariner 4 in the mid-1960s. NASA also has a renewed mandate to send astronauts beyond low Earth orbit to Mars as well as other destinations. Each robotic probe that flies by, orbits or lands on Mars is a prelude to the day when Americans step out of the Mars lander and tread the face of a second alien world. The human expedition to Mars, which will stop by the moon to top off rocket fuel created by lunar water, will be a singular, historic event of this century, dwarfing the Apollo moon landing.

China is mounting an expedition to Mars to enhance its status as a major space power. Beijing envisions its space program, which includes a planned crewed space station and several robotic expeditions to the moon leading to a crewed landing, as a means to define itself as a superpower, first as a peer of the United States, but in the long term to supplant America.

The UAE, conscious that oil and gas are beginning to lose their appeal, has embarked on creating a high-tech economy. The Hope mission, the first of its kind by any Arab nation, is part of that strategy.

Every iota of data gleaned by these missions, as well as everyone past and future, will support the grandest Mars vision of all. SpaceXs Elon MuskElon Reeve MuskNASA, China and the UAE are scheduled to send missions to Mars in July Kanye tweets he's running for president How competition will make the new space race flourish MORE has made no secret of his desire to found a city on the Red Planet, thus establishing, as the space visionary Robert Zubrin has advocated, a second branch of human civilization. The idea is to spark the pioneering spirit on Earth by opening a human frontier on the fourth planet from the sun, enabling innovation and optimism that has been sorely lacking in recent years. Coincidentally, Mars would become an insurance policy for the human race, ensuring that it does not become extinct due to some calamity, such as the object that crashed into the Earth, killing the dinosaurs 65 million years ago.

The ultimate dream is to use terraforming techniques to transform Mars into a habitable world, one of oceans and forests and an atmosphere that humans can breathe. Terraforming the Red Planet into a blue world would be the work of centuries. The process would restore Mars to what it once was billions of years ago, before a slow-motion calamity created the arid, chilly planet that we know today.

Musks dream, should it be fulfilled, would be as consequential as the emergence of life from the ocean to the land. It would constitute the evolution of humanity into a multi-planet species.

Mark Whittington, who writes frequently about space and politics, has published a political study of space exploration entitled Why is It So Hard to Go Back to the Moon? as well as The Moon, Mars and Beyond. He blogs at Curmudgeons Corner. He is published in the Wall Street Journal, Forbes, The Hill, USA Today, the LA Times, and the Washington Post, among other venues.

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Psoriasis: Treatments, medication, symptoms and more – TODAY – TODAY

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What is psoriasis? Psoriasis is a skin condition where your body makes new skin cells quickly. In about 80 to 90% of people with psoriasis, these skin cells build up in thick, scaly patches called psoriasis plaques, according to the American Academy of Dermatology (AAD). The condition is not contagious.

More than 8 million people in the U.S. have psoriasis, and it usually starts in the teen years or early 20s, though it can strike at any age, reports the National Psoriasis Foundation (NPF). It can develop in people of any race, and is more common in people who have a family member with the condition.

Dr. Carolyn Jacob, medical director of Chicago Cosmetic Surgery and Dermatology and a member of the American Academy of Dermatology (AAD), was diagnosed with psoriasis 36 years ago. Its what got me into dermatology, she said.

Untreated, people with psoriasis can leave a trail of unsightly scales that make them want to stay home. Most people dont care for that, said Dr. Amy McMichael, chair of the dermatology department at Wake Forest Baptist Health in North Carolina and a member of the American Academy of Dermatology. Now we can get those patients to where they have a very manageable disease.

Most people with psoriasis develop itchy, scaly plaques that are usually white or silver. They often crop up on the knees, elbows, lower back or scalp. On the scalp, they can spread to psoriasis of the face.

Less-common types of psoriasis can cause tiny pink bumps, skin thats sore and red, pus-filled bumps on the hands and feet or other skin problems. You can have more than one type of psoriasis.

Its also possible to have psoriasis with arthritis, where the psoriasis affects the joints. According to the NPF, 30 percent of people with psoriasis will go on to develop psoriatic arthritis.

Trending stories,celebrity news and all the best of TODAY.

What causes psoriasis? The immune system plays a role. With psoriasis, the white blood cells, or T-cells, in the bodys immune system attack the skin cells. The body responds by making more skin cells, which build up on top of the skin.

Theres also a genetic factor behind who gets psoriasis. But some people get psoriasis even though they dont have the genes that increase their risk, according to the AAD. And its possible that some people who do have the genes that increase their risk never develop psoriasis. Researchers think exposure to a trigger might kickstart psoriasis in people who are more likely to develop it.

There are certain triggers that can cause psoriasis for the first time. These triggers can also cause psoriasis flare-ups.

Triggers linked with psoriasis, according to the AAD:

Not every trigger causes flare-ups in every person with psoriasis, so its important to watch your symptoms and try to determine what could be causing them.

Your dermatologist will look over your skin, nails and scalp to check for signs of psoriasis, and ask about your symptoms, joint problems, family history and possible triggers.

Examining a skin sample under a microscope can help confirm a psoriasis diagnosis.

Psoriasis is almost always a lifelong condition. We dont have a cure, but we have many medications now that can make you feel like you dont have psoriasis, Jacob said. The medications have advanced so far since when I was diagnosed they used to call it the heartbreak of psoriasis.'

McMichael recalls an 18-year-old patient with severe psoriasis the plaques covered her body and she needed a wheelchair to get around. She had been through all the medications we had. Now you never see a patient like that, she said. Today, if one medication doesnt work there are a lot more to try. That has made the lives of psoriasis patients so much easier, she said.

According to the NPF, psoriasis treatment options include:

While todays treatments are highly effective, its often necessary to use a combination of different treatments to achieve clear or nearly clear skin and sometimes it can take months, or even years, to find a treatment regimen that works well for you, according to the NPF. But reducing your psoriasis is an important goal. Not only will it make your skin feel better, itll help improve your overall health, including any depression that may be related to your psoriasis; it can also reduce your risk of other conditions, such as diabetes and cardiovascular disease.

People with psoriasis and their providers can use the NPFs treatment targets for guidance on how soon results can be expected when trying out medication options. The NPF says that after 3 months on a medication, psoriasis should only appear on 1% or less of your body surface area, though 75% improvement is also acceptable. But if you havent reached 1% or less psoriasis on your body after 6 months on the treatment regimen (and if you havent had an acceptable response after 3 months), the NPF recommends discussing other treatment options with your doctor.

Additionally, if youve achieved success with a treatment regimen, but it stops working well, talk to your doctor about finding another treatment solution for your psoriasis.

Its one of my favorite skin conditions to treat because there are so many options to make it better, Jacob said. The new biologics work so well we can get peoples skin clear so they feel like they dont have psoriasis I forget I have it now.

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Psoriasis: Treatments, medication, symptoms and more - TODAY - TODAY

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Connection Between Psoriasis and Joint Disease Indicates Early Treatment Can Be Key – AJMC.com Managed Markets Network

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Researchers identified a protein that can not only worsen skin inflammation but also plays a key role in damaging joints and bones of patients with psoriasis.

Patients with psoriasis show higher rates of diverse comorbid conditions, such as psoriatic arthritis (PsA), which occurs in one-third of patients with psoriasis and can cause severe, disabling joint disease. However, the reason why so many people with psoriasis develop PsA hasnt been clear.

Since the damage that occurs as a result of PsA is irreversible, identifying patients with PsA early, before too much damage is done to bones, tendons, and joints, is an important consideration, researchers noted.

A team led by Case Western Reserve University School of Medicine researchers discovered that normalizing KLK6 can eliminate skin inflammation and reduce the arthritis-like damage.

"To discover that turning down KLK6 eliminated the skin inflammation and even improved the arthritis-like changesthat was unbelievable," Nicole Ward, PhD, the study's principal investigator and a professor of nutrition and dermatology at the medical school, said in a statement. "This suggests that clinicians need to aggressively treat patients with psoriasis to prevent the arthritis changes, which generally occur after the skin disease presents itself. Since the joint and bone damage are largely irreversible in patients, prevention becomes critical."

In previous research, Ward found that the skin of patients with psoriasis had 6 times more KLK6 than normal. In addition, the PAR1 receptor protein, which causes cellular/tissue responses like inflammation when activated, is overproduced in these patients skin and immune cells. The theory that came from these findings was that KLK6 drove inflammation through signaling of PAR1.

In this new study, the researchers overproduced KLK6 through genetic engineering to develop psoriasis-like skin disease. When PAR1 was deleted, there was a reduction in skin inflammation, as well as an improvement in bone and joint problems.

"These findings suggest that chronic inflammation originating in the skin has the capacity to cause distant joint and bone destruction seen in arthritis, according to Ward.

Reference

Billi AC, Ludwig JE, Fritz Y, et al. KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease. J Clin Invest. 2020;130(6):3151-3157. doi:10.1172/JCI133159

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New Comprehensive Report on Psoriasis Treatment Market to Witness an Outstanding Growth during 2020 2025 with Top Players Like Pfizer Inc., Merck and…

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Latest Research Report: Psoriasis Treatment industry

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

Global Psoriasis Treatment Market documents a detailed study of different aspects of the Global Market. It shows the steady growth in market in spite of the fluctuations and changing market trends. The report is based on certain important parameters.

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Psoriasis Treatment Market competition by top manufacturers as follow: , Novartis International AG, Johnson & Johnson, Pfizer Inc., Merck and Co. Inc., AbbVie and Amgen, Eli Lilly

The risingtechnology in Psoriasis Treatmentmarketis also depicted in thisresearchreport. Factors that are boosting the growth of the market, and giving a positive push to thrive in the global market is explained in detail. It includes a meticulous analysis of market trends, market shares and revenue growth patterns and the volume and value of the market. It is also based on a meticulously structured methodology. These methods help to analyze markets on the basis of thorough research and analysis.

The Type Coverage in the Market are: , TNF Inhibitors, Phosphodiesterase Inhibitors, Interleukin Blockers, Others

Market Segment by Applications, covers: , Oral, Tropical, Injectable

The research report summarizes companies from different industries. This Psoriasis Treatment Market report has been combined with a variety of market segments such as applications, end users and sales. Focus on existing market analysis and future innovation to provide better insight into your business. This study includes sophisticated technology for the market and diverse perspectives of various industry professionals.

Psoriasis Treatment is the arena of accounting worried with the summary, analysis and reporting of financial dealings pertaining to a business. This includes the training of financial statements available for public ingesting. The service involves brief, studying, checking and reporting of the financial contacts to tax collection activities and objects. It also involves checking and making financial declarations, scheming accounting systems, emerging finances and accounting advisory.

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Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Report Highlights: Detailed overview of parent market Changing market dynamics in the industry In-depth market segmentation Historical, current and projected market size in terms of volume and value Recent industry trends and developments Competitive landscape Strategies of key players and products offered Potential and niche segments, geographical regions exhibiting promising growth A neutral perspective on market performance Must-have information for market players to sustain and enhance their market footprint

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(2020-2025) Psoriasis Treatment Market Estimated To Experience A Hike in Growth | Global Industry Size, Growth, Segments, Revenue, Manufacturers -…

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Psoriasis TreatmentMarket 2020: Inclusive Insight

Los Angeles, United States,July 2020:The report titled Global Psoriasis Treatment Market is one of the most comprehensive and important additions to Alexareports archive of market research studies. It offers detailed research and analysis of key aspects of the global Psoriasis Treatment market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Psoriasis Treatment market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Psoriasis Treatment market is carefully analyzed and researched about by the market analysts.

Psoriasis Treatment Market competition by top manufacturers/ Key player Profiled: Novartis International AG, Johnson & Johnson, Pfizer Inc., Merck and Co. Inc., AbbVie and Amgen, Eli Lilly

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Global Psoriasis Treatment Market is estimated to reach xxx million USD in 2020 and projected to grow at the CAGR of xx% during 2020- 2025. According to the latest report added to the online repository of Alexareports the Psoriasis Treatment market has witnessed an unprecedented growth till 2020. The extrapolated future growth is expected to continue at higher rates by 2025.

Based on region, the globalPsoriasis Treatment market has been segmented into Americas (North America ((the U.S. and Canada),) and Latin Americas), Europe (Western Europe (Germany, France, Italy, Spain, UK and Rest of Europe) and Eastern Europe), Asia Pacific (Japan, India, China, Australia & South Korea, and Rest of Asia Pacific), and Middle East & Africa (Saudi Arabia, UAE, Kuwait, Qatar, South Africa, and Rest of Middle East & Africa).

Psoriasis Treatment Market Segment by Type covers: TNF Inhibitors, Phosphodiesterase Inhibitors, Interleukin Blockers

Psoriasis Treatment Market Segment by Industry: Oral, Tropical, Injectable

After reading the Psoriasis Treatment market report, readers get insight into:

*Major drivers and restraining factors, opportunities and challenges, and the competitive landscape*New, promising avenues in key regions*New revenue streams for all players in emerging markets*Focus and changing role of various regulatory agencies in bolstering new opportunities in various regions*Demand and uptake patterns in key industries of the Psoriasis Treatment market*New research and development projects in new technologies in key regional markets*Changing revenue share and size of key product segments during the forecast period*Technologies and business models with disruptive potential

Key questions answered in the report:

What will the market growth rate of Psoriasis Treatment market?What are the key factors driving the global Psoriasis Treatment market size?Who are the key manufacturers in Psoriasis Treatment market space?What are the market opportunities, market risk and market overview of the Psoriasis Treatmentmarket?What are sales, revenue, and price analysis of top manufacturers of Psoriasis Treatment market?Who are the distributors, traders, and dealers of Psoriasis Treatment market?What are the Psoriasis Treatment market opportunities and threats faced by the vendors in the global Psoriasis Treatmentindustries?What are sales, revenue, and price analysis by types and applications of Psoriasis Treatmentmarket?What are sales, revenue, and price analysis by regions of Psoriasis Treatment industries?

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Table of ContentsSection 1 Psoriasis Treatment Product DefinitionSection 2 Global Psoriasis Treatment Market Manufacturer Share and Market Overview2.1 Global Manufacturer Psoriasis Treatment Shipments2.2 Global Manufacturer Psoriasis Treatment Business Revenue2.3 Global Psoriasis Treatment Market Overview2.4 COVID-19 Impact on Psoriasis Treatment IndustrySection 3 Manufacturer Psoriasis Treatment Business Introduction3.1 Novartis International AG Psoriasis Treatment Business Introduction3.1.1 Novartis International AG Psoriasis Treatment Shipments, Price, Revenue and Gross profit 2015-20203.1.2 Novartis International AG Psoriasis Treatment Business Distribution by Region3.1.3 Novartis International AG Interview Record3.1.4 Novartis International AG Psoriasis Treatment Business Profile3.1.5 Novartis International AG Psoriasis Treatment Product Specification3.2 Johnson & Johnson Psoriasis Treatment Business Introduction3.2.1 Johnson & Johnson Psoriasis Treatment Shipments, Price, Revenue and Gross profit 2015-20203.2.2 Johnson & Johnson Psoriasis Treatment Business Distribution by Region3.2.3 Interview Record3.2.4 Johnson & Johnson Psoriasis Treatment Business Overview3.2.5 Johnson & Johnson Psoriasis Treatment Product Specification3.3 Pfizer Inc. Psoriasis Treatment Business Introduction3.3.1 Pfizer Inc. Psoriasis Treatment Shipments, Price, Revenue and Gross profit 2015-20203.3.2 Pfizer Inc. Psoriasis Treatment Business Distribution by Region3.3.3 Interview Record3.3.4 Pfizer Inc. Psoriasis Treatment Business Overview3.3.5 Pfizer Inc. Psoriasis Treatment Product Specification3.4 Merck and Co. Inc. Psoriasis Treatment Business Introduction3.5 AbbVie and Amgen Psoriasis Treatment Business Introduction3.6 Eli Lilly Psoriasis Treatment Business IntroductionSection 4 Global Psoriasis Treatment Market Segmentation (Region Level)4.1 North America Country4.1.1 United States Psoriasis Treatment Market Size and Price Analysis 2015-20204.1.2 Canada Psoriasis Treatment Market Size and Price Analysis 2015-20204.2 South America Country4.2.1 South America Psoriasis Treatment Market Size and Price Analysis 2015-20204.3 Asia Country4.3.1 China Psoriasis Treatment Market Size and Price Analysis 2015-20204.3.2 Japan Psoriasis Treatment Market Size and Price Analysis 2015-20204.3.3 India Psoriasis Treatment Market Size and Price Analysis 2015-20204.3.4 Korea Psoriasis Treatment Market Size and Price Analysis 2015-20204.4 Europe Country4.4.1 Germany Psoriasis Treatment Market Size and Price Analysis 2015-20204.4.2 UK Psoriasis Treatment Market Size and Price Analysis 2015-20204.4.3 France Psoriasis Treatment Market Size and Price Analysis 2015-20204.4.4 Italy Psoriasis Treatment Market Size and Price Analysis 2015-20204.4.5 Europe Psoriasis Treatment Market Size and Price Analysis 2015-20204.5 Other Country and Region4.5.1 Middle East Psoriasis Treatment Market Size and Price Analysis 2015-20204.5.2 Africa Psoriasis Treatment Market Size and Price Analysis 2015-20204.5.3 GCC Psoriasis Treatment Market Size and Price Analysis 2015-20204.6 Global Psoriasis Treatment Market Segmentation (Region Level) Analysis 2015-20204.7 Global Psoriasis Treatment Market Segmentation (Region Level) AnalysisSection 5 Global Psoriasis Treatment Market Segmentation (Product Type Level)5.1 Global Psoriasis Treatment Market Segmentation (Product Type Level) Market Size 2015-20205.2 Different Psoriasis Treatment Product Type Price 2015-20205.3 Global Psoriasis Treatment Market Segmentation (Product Type Level) AnalysisSection 6 Global Psoriasis Treatment Market Segmentation (Industry Level)6.1 Global Psoriasis Treatment Market Segmentation (Industry Level) Market Size 2015-20206.2 Different Industry Price 2015-20206.3 Global Psoriasis Treatment Market Segmentation (Industry Level) AnalysisSection 7 Global Psoriasis Treatment Market Segmentation (Channel Level)7.1 Global Psoriasis Treatment Market Segmentation (Channel Level) Sales Volume and Share 2015-20207.2 Global Psoriasis Treatment Market Segmentation (Channel Level) AnalysisSection 8 Psoriasis Treatment Market Forecast 2020-20258.1 Psoriasis Treatment Segmentation Market Forecast (Region Level)8.2 Psoriasis Treatment Segmentation Market Forecast (Product Type Level)8.3 Psoriasis Treatment Segmentation Market Forecast (Industry Level)8.4 Psoriasis Treatment Segmentation Market Forecast (Channel Level)Section 9 Psoriasis Treatment Segmentation Product Type9.1 TNF Inhibitors Product Introduction9.2 Phosphodiesterase Inhibitors Product Introduction9.3 Interleukin Blockers Product IntroductionSection 10 Psoriasis Treatment Segmentation Industry10.1 Oral Clients10.2 Tropical Clients10.3 Injectable ClientsSection 11 Psoriasis Treatment Cost of Production Analysis11.1 Raw Material Cost Analysis11.2 Technology Cost Analysis11.3 Labor Cost Analysis11.4 Cost OverviewSection 12 Conclusion

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(2020-2025) Psoriasis Treatment Market Estimated To Experience A Hike in Growth | Global Industry Size, Growth, Segments, Revenue, Manufacturers -...

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Psoriatic Arthritis Drugs Market Growth By Manufacturers, Type And Application, Forecast To 2026 – 3rd Watch News

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New Jersey, United States,- Market Research Intellect sheds light on the market scope, potential, and performance perspective of the Global Psoriatic Arthritis Drugs Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the global Psoriatic Arthritis Drugs market.

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Leading Psoriatic Arthritis Drugs manufacturers/companies operating at both regional and global levels:

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Industrial Analysis:

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In Market Segmentation by Types of Psoriatic Arthritis Drugs, the report covers-

In Market Segmentation by Applications of the Psoriatic Arthritis Drugs, the report covers the following uses-

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Sales Forecast:

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In the end, the Psoriatic Arthritis Drugs market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the global Psoriatic Arthritis Drugs market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

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Psoriatic Arthritis Drugs Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

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Massive Shift in Practice Patterns in Psoriatic Arthritis as Rheumatologists Lean Toward Increased Use of JAK inhibitors and Novel Biologics – WFMZ…

Posted: at 3:51 am

EXTON, Pa., July 2, 2020 /PRNewswire/ -- Over the past four years, multiple new agents have been FDA approved for the treatment of psoriatic arthritis (PsA), including Pfizer's Xeljanz, Eli Lilly's Taltz, BMS' Orencia, and Janssen's Simponi Aria. In addition, the development pipeline is ripe with many new agents offering novel mechanism approaches, including UCB's bimekizumab and BMS' TYK2 inhibitor (BMS-986165), that will join likely PsA line extensions of Janssen's Tremfya, Sun Pharma's Ilumya, and AbbVie's Rinvoq and Skyrizi.

Each year, Spherix Global Insights collaborates with approximately 200 rheumatologists to conduct large scale, retrospective patient chart audits, exclusively focusing on recent trends in PsA switching patterns. The 2020 audit, which was released last week, highlights recent switching patterns for 1,008 patients with PsA who are being treated with a biologic, JAK inhibitor, or Amgen's Otezla. Notably, this is the first year that Otezla is under Amgen's domain, after being divested by Celgene in accordance with the acquisition by BMS.

At the end of 2015, switching patterns in PsA were still largely driven by TNF inhibitor sequencing, with more than one-half of the recent switches occurring within the class. In each sequential year, TNF cycling eroded, with the most recent results indicating that fewer than one-in-four of patients are now treated with two consecutive TNFs. Collectively, the IL-17s (Novartis' Cosentyx and Eli Lilly's Taltz) grew switching share from virtually nothing in late 2015 to approximately one-quarter of switches in the present audit. The approval of Xeljanz for PsA in December 2017 also caused some disruption, introducing an oral challenger to Otezla. Switches both from and to oral agents increased substantially since the first edition of this study several years ago.

Rheumatologists have consistently reported that among their PsA patients being treated with biologics or advanced small molecules, slightly more than one-quarter are switched in any given year, making the competition for second-line agents fierce. There is less opportunity for later-line switching, making it critical to be positioned as the first-line or first-switch brand. An evaluation of first-line treatment among patients who ultimately switched indicates dwindling first-line use of Amgen's Enbrel over the past three years, but an uptick in Otezla keeping the company's portfolio largely net neutral in first-line use.

However, since late 2015, Enbrel and Otezla have collectively forfeited second-line share, dropping from 38% to 21% over the four-year period. Furthermore, Enbrel was poised to capture an incremental 9% of the recent switches, ultimately losing out to AbbVie's Humira most frequently, but also losing to Amgen's own Otezla in more than 10% of the cases. Market access seems to be helping Enbrel stay in the game in more than half of the cases where patients were switched to Enbrel, the rheumatologist would have selected a different agent if market access were not a factor.

As expected, most switching is based on the desire for improved efficacy in joints, but often the decision is multi-factorial, with rheumatologists reporting that patients themselves are often the drivers in more than one-quarter of the cases. The reasons for selection of the new agent vary by mechanism of action and brand, with Xeljanz and Otezla benefitting from patient requests and a desire for the oral formulation. Humira and Enbrel are often selected based on habit, while others stake a claim on specific patient types: Orencia for patients with multiple co-morbidities; Taltz when skin efficacy is desired; and Cimzia when family planning considerations are at play.

The market will soon be crowded with even more treatment options. Rheumatologists report the greatest familiarity with AbbVie's Rinvoq for PsA, which was approved last August and has had a meteoric rise in rheumatoid arthritis (see RealTime Dynamix: Rheumatoid Arthritis (US)). Comparably, there is less familiarity with bimekizumab, Tremfya, Skyrizi, Ilumya, and BMS-986165. Rinvoq looks to pose the greatest threat to Xeljanz; bimekizumab to the IL-17s; and Tremfya to Cosentyx and Janssen's own Stelara.

Being positioned clinically (with strong joint efficacy data) and from a market access perspective to compete in the first- or second-line position is critical to optimizing performance in the PsA market. Secondary strategies include being able to carve out a sizable patient profile niche and/or driving patient requests through DTC and the development of patient-preferred formulations.

About RealWorld DynamixRealWorld Dynamix: Biologic/Small Molecule Switching in PsA (US) is an independent, data-driven service unmasking real patient management patterns through annual reports based on chart audits of ~1,000 patients. The report uncovers the "why" behind treatment decisions, includes year over year trending to quantify key aspects of market evolution, and integrates specialists' attitudinal & demographic data to highlight differences between stated and actual treatment patterns.

About Spherix Global InsightsSpherix Global Insights is a hyper-focused market intelligence firm that leverages our own independent data and expertise to provide strategic guidance, so biopharma stakeholders make decisions with confidence. We specialize in select immunology, nephrology, and neurology markets.

All company, brand or product names in this document are trademarks of their respective holders.

For more information contact:Kristen Henn, Business Development ManagerEmail:info@spherixglobalinsights.comwww.spherixglobalinsights.com

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Massive Shift in Practice Patterns in Psoriatic Arthritis as Rheumatologists Lean Toward Increased Use of JAK inhibitors and Novel Biologics - WFMZ...

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Psoriasis Drugs Market Growth By Manufacturers, Type And Application, Forecast To 2026 – 3rd Watch News

Posted: at 3:51 am

New Jersey, United States,- Market Research Intellect sheds light on the market scope, potential, and performance perspective of the Global Psoriasis Drugs Market by carrying out an extensive market analysis. Pivotal market aspects like market trends, the shift in customer preferences, fluctuating consumption, cost volatility, the product range available in the market, growth rate, drivers and constraints, financial standing, and challenges existing in the market are comprehensively evaluated to deduce their impact on the growth of the market in the coming years. The report also gives an industry-wide competitive analysis, highlighting the different market segments, individual market share of leading players, and the contemporary market scenario and the most vital elements to study while assessing the global Psoriasis Drugs market.

The research study includes the latest updates about the COVID-19 impact on the Psoriasis Drugs sector. The outbreak has broadly influenced the global economic landscape. The report contains a complete breakdown of the current situation in the ever-evolving business sector and estimates the aftereffects of the outbreak on the overall economy.

Leading Psoriasis Drugs manufacturers/companies operating at both regional and global levels:

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The Psoriasis Drugs market report provides successfully marked contemplated policy changes, favorable circumstances, industry news, developments, and trends. This information can help readers fortify their market position. It packs various parts of information gathered from secondary sources, including press releases, web, magazines, and journals as numbers, tables, pie-charts, and graphs. The information is verified and validated through primary interviews and questionnaires. The data on growth and trends focuses on new technologies, market capacities, raw materials, CAPEX cycle, and the dynamic structure of the Psoriasis Drugs market.

This study analyzes the growth of Psoriasis Drugs based on the present, past and futuristic data and will render complete information about the Psoriasis Drugs industry to the market-leading industry players that will guide the direction of the Psoriasis Drugs market through the forecast period. All of these players are analyzed in detail so as to get details concerning their recent announcements and partnerships, product/services, and investment strategies, among others.

Sales Forecast:

The report contains historical revenue and volume that backing information about the market capacity, and it helps to evaluate conjecture numbers for key areas in the Psoriasis Drugs market. Additionally, it includes a share of each segment of the Psoriasis Drugs market, giving methodical information about types and applications of the market.

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This report gives a forward-looking prospect of various factors driving or restraining market growth.

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This report helps the readers understand key product segments and their future.

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In the end, the Psoriasis Drugs market is analyzed for revenue, sales, price, and gross margin. These points are examined for companies, types, applications, and regions.

To summarize, the global Psoriasis Drugs market report studies the contemporary market to forecast the growth prospects, challenges, opportunities, risks, threats, and the trends observed in the market that can either propel or curtail the growth rate of the industry. The market factors impacting the global sector also include provincial trade policies, international trade disputes, entry barriers, and other regulatory restrictions.

About Us:

Market Research Intellect provides syndicated and customized research reports to clients from various industries and organizations with the aim of delivering functional expertise. We provide reports for all industries including Energy, Technology, Manufacturing and Construction, Chemicals and Materials, Food and Beverage, and more. These reports deliver an in-depth study of the market with industry analysis, the market value for regions and countries, and trends that are pertinent to the industry.

Contact Us:

Mr. Steven Fernandes

Market Research Intellect

New Jersey ( USA )

Tel: +1-650-781-4080

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Psoriasis Drugs Market Growth By Manufacturers, Type And Application, Forecast To 2026 - 3rd Watch News

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BestBitcoinCasino.com gives Online Casinos a voice with the launch of new ‘Manage Casino’ feature – CalvinAyre.com

Posted: at 3:49 am

Birmingham, July 2020

Beginning today, online casinos that have been featured and reviewed in the Bitcoin Casino Review section now have the ability to have partial control of their review page on BestBitcoinCasino.com.

This is made possible with the newly launched function called Manage Casino feature, which enables casino officials and affiliate managers to be their official representative on the said website. To become the official casino manager, casino officials must create an account with BestBitcoinCasino.com then select the Manage a Casino button on the user dashboard and complete the form.

Weve opened BestBitcoinCasino.com to the management of online casinos with two goals in mind. First is for us to ensure that the casino details on our review pages are accurate and updated. Second is for our website to become a venue where casino representatives and players can directly communicate, creating a dynamic environment for all parties, said Barry Goldwon, manager at BestBitcoinCasino.com.

The new Manage Casino feature enables official casino managers to perform certain actions, namely:

BestBitcoinCasino.com ensures that all casino reviews remain unbiased and independent as the powers of casino managers are limited to modifying only the casino reviews specifications. The BestBitcoinCasino.com management guarantees that casino managers cannot change the review, ratings, and recommendations given by the team.

The team also implements a strict evaluation process for the casino manager position to protect the reputation and welfare of both the casinos and the players from bogus applicants.

About BestBitcoinCasino.com

BestBitcoinCasino.com is a trusted online partner for the iGaming industry since 2013. Its mission is to provide players and operators with information and education to develop a safer gambling and betting environment. BestBitcoinCasino.com believes in the opportunities for cryptocurrency and blockchain for online casinos and industry players.

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BestBitcoinCasino.com gives Online Casinos a voice with the launch of new 'Manage Casino' feature - CalvinAyre.com

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