Daily Archives: February 27, 2020

Artificial Intelligence and Big Data forms focus on ENGEL’s medical technology conference – Plastics Insight

Posted: February 27, 2020 at 2:15 am

The medical technology conference med.con 2020, hosted by ENGEL at its Technologieforum in Stuttgart during mid February, was a huge success. The conference was a full house as more than 100 delegates attended it.

The main talk point at the conference was patient safety through advanced technology and was discussed from the various perspectives of plastics processing in the cleanroom and conveyed in a tangible way using live machine exhibits.

With artificial intelligence and big data being the focus, it was deliberated that the potential for more quality, safety, and cost-efficiency in medical technology is yet to be fully exploited.

Summing up the massive challenge that the volume of data generated is increasing, but the use of the data is not, Uwe Herbert, IT manager at Ypsomed, a manufacturer of injection systems for self-medication, in his keynote address mentions, We are passing up opportunities here

Uwe advocates that it is necessary to link the IT system of the individual department in the company and provide the employees with the freedom they need to experiment with the new possibilities to improve the quality of the products and reduce the unit costs. However, according to Uwe, the complexity of these projects is often underestimated.

Speaking of artificial intelligence, Christian Pommereau, principal engineer with pharmaceutical company Sanofi-Aventis Deutschland, emphasizes, We need to shift up a gear when it comes to artificial intelligence. To avoid the plastics processing industry losing touch, we need everyone around the table, adds Christian. He has witnessed within his own group of companies how far ahead the drug production industry is in this field.

Both the above-mentioned speakers sparked a lively discussion. It became clear that the industry has long recognized the great potential that Industry 4.0 has to offer. But obstacles often remain to adopt the new technologies for reflecting the specific requirements of cleanroom production. For instance, the validation of dynamic process control with the help of intelligent assistance, an important feature of the smart factory, has to be planned in detail and designed safely.

Christoph Lhota, vice president, ENGEL medical, reported on how ENGELs iQ weight control assistance system can be integrated into rules and regulations accepted by the auditors, based on ongoing development work.

The ENGEL developers have investigated various approaches to the validation process and ultimately derived a procedure that defines process windows for the parameters to be retroactively adjusted, enabling the validation of dynamically controlled processes in conformity with both EN ISO and the FDA.

In his keynote, Christoph gave an outlook on other topics that are gaining in importance in medical technology and on which ENGELs developers are working intensively. These comprise of injection molding of liquid silicone rubber in the cleanroom, efficient injection molding of very small batch sizes and sterile injection molding, like cleanroom class ISO 5 is increasingly required in plastics processing.

Talking about ISO 5, Christoph informs, It is a totally different planet. The opening speed of the injection molding machine is significant here. To specifically adapt its machines, robots and technologies to this new class of requirements, ENGEL operates its own clean room at its headquarters in Schwertberg.

Among the eight presentations during the keynote session, other speakers were Martin Maier from Waldorf Technik, Reinhard Steger from Braunform, Martin Jungbluth from Max Petek Reinraumtechnik, and Jrg Leonhartsberger and Claus Wilde from ENGEL.

During the conference, especially in the breaks, and following the talks, ENGEL opened up its technology center with live exhibits and a partner exhibition.

ENGELs high level of expertise in systems solutions was noticeable in the clean room injection molding applications. Sophisticated medical products were manufactured in highly-integrated and automated production cells throughout the event.

There were thick-walled housing parts which can be produced in an 8-cavity mold using servo-electric Vario-Spinstack technology from Hack Formenbau in particularly short cycle times and with a correspondingly low unit cost, thanks to the two-component process.

It also showcased needle holders for 1 ml safety syringes in a 16-cavity mold by Fostag Formenbau with a particularly low shot weight of 0.08 grams per part. The needle holders very thin and different wall thicknesses require extremely precise process control, which ENGEL ensures with iQ weight control.

The needle holders are taken off by a viper linear robot and transferred to the pipe distribution system, developed by ENGEL and made completely of stainless steel, in order to package the filigree mouded parts sorted by cavity.

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Air Travelers Cant See All of It, but More Tech Is Moving Them Along – The New York Times

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The time an airplane spends waiting for a gate after landing or waiting in line to take off could also be reduced. A group at SITA focused on airport management systems is helping to design technology that can synthesize data from many sources, including changing aircraft arrival times, weather conditions at destination airports and logistical issues to improve runway schedules and gate assignments.

Artificial intelligence software can also make a difference with rebooking algorithms, Mr. Etzioni said. When weather or mechanical issues disrupt travel, the airlines speed in recomputing, rerouting and rescheduling matters, he said.

The data streams get even more complex when the whole airport is considered, Ms. Stein of SITA said. A number of airports are creating a digital twin of their operations using central locations with banks of screens that show the systems, people and objects at the airport, including airplane locations and gate activity, line lengths at security checkpoints, and the heating, cooling and electrical systems monitored by employees who can send help when needed. These digital systems can also be used to help with emergency planning.

The same types of thermal, audio and visual sensors that can be used to supply data to digital twins are also being used to reduce equipment breakdowns. Karen Panetta, the dean of graduate engineering at Tufts University and a fellow at the Institute of Electrical and Electronics Engineers, said hand-held thermal imagers used before takeoff and after landing can alert maintenance crews if an area inside the airplanes engine or electrical system is hotter than normal, a sign something may be amiss. The alert would help the crew schedule maintenance right away, rather than be forced to take the aircraft out of service at an unexpected time and inconvenience passengers.

At the moment, people, rather than technology, evaluate most of the data collected, Dr. Panetta said. But eventually, with enough data accumulated and shared, more A.I. systems could be built and trained to analyze the data and recommend actions faster and more cost effectively, she said.

Air travel isnt the only segment of the transportation industry to begin using artificial intelligence and machine learning systems to reduce equipment failure. In the maritime industry, a Seattle company, ioCurrents, digitally monitors shipping vessel engines, generators, gauges, winches and a variety of other mechanical systems onboard. Their data is transmitted in real time to a cloud-based A.I. analytics platform, which flags potential mechanical issues for workers on the ship and on land.

A.I. systems like these and others will continue to grow in importance as passenger volume increases, Ms. Stein said. Airports can only scale so much, build so much and hire so many people.

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Air Travelers Cant See All of It, but More Tech Is Moving Them Along - The New York Times

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What to do about artificially intelligent government | TheHill – The Hill

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The White Houses recent efforts to chart a national artificial intelligence (AI) policy are welcome and, frankly, overdue. Funding for AI research and updating agency IT systems is a good start. So is guidance for agencies as they begin to regulate industry use of AI. But theres a glaring gap: The White House has been silent about the rules that apply when agencies use AI to perform critical governance tasks.

This matters because, of all the ways AI is transforming our world, some of the most worrying come at the intersection of AI and the awesome power of the state. AI drives the facial recognition police use to surveil citizens. It enables the autonomous weapons changing warfare. And it powers the tools judges use to make life-changing bail, sentencing and parole decisions. Concerns about each have fueled debate and, as to facial recognition in particular, new laws banning use.

Sitting just beyond the headlines, however, is a little-known fact: AI use already is pervasive in government. Prohibition for most uses is not an option, or at least not a wise one. Needed instead is a frank conversation about how to give the government the resources it needs to develop high-quality and fairly deployed AI tools and build sensible accountability mechanisms around their use.

We know because we led a team of lawyers and computer scientists at Stanford and New York universities to advise federal agencies on how to develop and oversee their new algorithmic toolkit.

Our research shows that AI use spans government. By our estimates, half of major federal agencies have experimented with AI. Among the 160 AI uses we found, some such as facial recognition are fueling public outcries. But many others fly under the radar. The Securities and Exchange Commission (SEC) uses AI to flag insider trading; the Centers for Medicare and Medicaid Services uses it to ferret out health care fraud. The Social Security Administration is piloting AI tools to help decide who gets disability benefits, and the Patent and Trademark Office to decide who gets patent protection.

Still other agencies are developing AI tools to communicate with the public, by sifting millions of consumer complaints or using chatbots to field questions from welfare beneficiaries, asylum seekers and taxpayers.

Our research also highlights AIs potential to make government work better and at lower cost. AI tools that help administrative judges spot errors in draft decisions can shrink backlogs that leave some veterans waiting years (sometimes, close to a decade) for benefits. AI can help ensure that the decision to launch a potentially ruinous enforcement action does not reflect the mistakes, biases, or whims of human prosecutors. And AI can help make more precise judgments about which drugs threaten public health.

But the picture is not all rosy.

First, the government has a long way to go. Our teams computer scientists found that few agency AI uses rival the sophistication found in the private sector, making it harder to realize accuracy and efficiency gains. Some may wish to keep agencies low-tech to limit surveillance or otherwise hamstring government. Its not that simple: Government use of makeshift and insecure AI systems puts everyone at risk. Disabled persons, veterans and all of us deserve better.

Second, AI poses deep accountability challenges. When public officials make decisions affecting rights, the law generally requires an explanation. This reason-giving requirement is deeply embedded in law and even enshrined in the Constitution. Yet sophisticated AI tools are opaque; they do not serve up explanations with their outputs. A crucial challenge is how to subject these tools to meaningful accountability and ensure fidelity to longstanding commitments to transparency, reason-giving and non-discrimination.

To address concerns, agencies could be required to politically ventilate AI tools the way they must new regulations. Or they could be made to benchmark AI tools, reserving a pool of cases for human decision and comparing results to AI-assisted ones. However, there are no one-size-fits-all solutions. Open-sourcing computer code might make sense when agencies distribute welfare benefits. But disclosing details when tax enforcers use AI to identify cheaters will just aid evasion.

Third, if we want agencies to make responsible use of AI, their capacity must come from within. Our research shows that many of the best-designed AI tools were created by innovative, public-spirited agency technologists not profit-driven private contractors. The AI tools that help adjudicate disability benefits at the Social Security Administration came from agency insiders with intimate knowledge of governing law and how administrative judges work.

This makes sense. Government work is often complex. Recruiting skilled technologists and updating outmoded computing systems is crucial to building high-quality AI tools and administering them fairly. But it wont be cheap.

Last, AI can fuel political anxieties. Government AI use creates a risk of gaming by better-heeled groups with resources and knowhow. The SECs algorithmic predictions may fall more heavily on smaller companies that, unlike big Wall Street players, lack a stable of quants who can reverse-engineer the model and keep out of the agencys cross-hairs. If citizens come to believe AI systems are rigged, political support for a more effective, tech-savvy government will evaporate.

In short, this is a pivotal moment for government. Managed well, agency AI use can make the government more efficient, accurate and fair. Managed poorly, AI can widen the public-private technology gap, make agencies more vulnerable and less transparent, and heighten concerns about government arbitrariness and biases that are coursing through American politics.

Wherever the nation lands on facial recognition, government AI use is here to stay. The question now is which of these two visions becomes reality.

David F. Engstrom and Daniel E. Ho are professors of law at Stanford University. Catherine M. Sharkey is a professor of law at New York University. Mariano-Florentino Cullar is a justice on the California Supreme Court and professor of law at Stanford University.

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Global Enterprise Artificial Intelligence Market Expected to Grow with a CAGR of 35.4% Over the Forecast Period, 2019-2026 – ResearchAndMarkets.com -…

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DUBLIN--(BUSINESS WIRE)--The "Enterprise Artificial Intelligence Market: Global Opportunity Analysis And Industry Forecast, 2019-2026" report has been added to ResearchAndMarkets.com's offering.

According to this report, the global enterprise artificial intelligence market was valued at $4.68 billion in 2018, and is projected to reach $53.06 billion by 2026, registering a CAGR of 35.4% from 2019 to 2026.

Artificial intelligence has been one of the fastest growing technologies in recent years. AI is associated to human intelligence with similar characteristics, such as language understanding, reasoning, learning, problem solving, and others. Manufacturers in the market witness enormous underlying intellectual challenges in the development and revision of such technology. AI is positioned at the core of the nextogen software technologies in the market. Companies, such as Google, IBM, Microsoft, and other leading players, have actively implemented AI as a crucial part of their technologies.

The increase in number of innovative start-ups and advancements in technology have led to rise in investment in artificial intelligence technologies. Moreover, escalating demand for analyzing and interpreting large amount of data boosts the requirement of artificial intelligence industry solutions. Moreover, development of more reliable cloud computing infrastructures and improvements in dynamic artificial intelligence solutions have a strong impact on the growth potential of the AI market. However, lack of trained and experienced staff hinders the growth of the enterprise Artificial Intelligence (AI) market. Furthermore, increase in adoption of AI in developing economies, such as China, and India are expected to provide major opportunities for the market growth in the upcoming years. Also, ongoing developments in smart virtual assistants and robots are anticipated to be opportunistic for the growth of the enterprise artificial intelligence (AI) market.

KEY BENEFITS

Key Topics Covered:

Chapter 1: Introduction

1.1. Report Description

1.2. Key Benefits For Stakeholders

1.3. Key Market Segments

1.4. Research Methodology

1.4.1. Secondary Research

1.4.2. Primary Research

1.4.3. Analyst Tools & Models

Chapter 2: Executive Summary

2.1. Cxo Perspective

Chapter 3: Market Overview

3.1. Market Definition And Scope

3.2. Key Findings

3.2.1. Top Investment Pockets

3.2.2. Top Impacting Factors

3.3. Porter'S Five Forces Analysis

3.4. Key Player Positioning, 2017

3.5. Market Dynamics

3.5.1. Drivers

3.5.1.1. Increasing Investment In Ai Technologies

3.5.1.2. Growing Need For Analyzing And Interpreting Large Amounts of Data

3.5.1.3. Increasing Customer Satisfaction And Adoption of Reliable Cloud Applications

3.5.2. Restraints

3.5.2.1. Lack of Trained And Experienced Staff

3.5.3. Opportunities

3.5.3.1. Increase In Adoption of Ai In Developing Economies

3.5.3.2. Developing Smarter Virtual Assistants And Robots

3.6. Market Evolution/ Industry Roadmap

Chapter 4: Global Enterprise Artificial Intelligence (Ai) Market, By Deployment Type

4.1. Market Overview

4.2. Cloud

4.2.1. Key Market Trends, Growth Factors, And Opportunities

4.2.2. Market Size And Forecast, By Region

4.2.3. Market Analysis, By Country

4.3. On-Premise

4.3.1. Key Market Trends, Growth Factors, And Opportunities

4.3.2. Market Size And Forecast, By Region

4.3.3. Market Analysis, By Country

Chapter 5: Global Enterprise Artificial Intelligence (Ai) Market, By Technology

5.1. Market Overview

5.2. Machine Learning

5.3. Natural Language Processing (Nlp)

5.4. Image Processing

5.5. Speech Recognition

Chapter 6: Global Enterprise Artificial Intelligence (Ai) Market, By Organization Size

6.1. Market Overview

6.2. Large Enterprises

6.3. Small And Medium Enterprises (Smes)

Chapter 7: Global Enterprise Artificial Intelligence (Ai) Market, By Industry Vertical

7.1. Market Overview

7.2. Media & Advertising

7.3. Bfsi

7.4. It & Telecom

7.5. Retail

7.6. Healthcare

7.7. Automotive & Transportation

7.8. Others

Chapter 8: Global Enterprise Artificial Intelligence (Ai) Market, By Region

8.1. Market Overview

8.2. North America

8.3. Europe

8.4. Asia-Pacific

8.5. LAMEA

Chapter 9: Competitive Landscape

9.1. Competitive Dashboard

9.2. Key Developments

9.3. Top Winning Strategies

Chapter 10: Company Profiles

10.1. Alphabet Inc.

10.2. Apple Inc.

10.3. Amazon Web Services, Inc.

10.4. International Business Machines Corporation

10.5. Ipsoft Inc.

10.6. Microstrategy Incorporated

10.7. Nvidia Corporation

10.8. Sap Se

10.9. Verint Systems Inc.

10.10. Wipro Limited

For more information about this report visit https://www.researchandmarkets.com/r/w3dpp3

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Compliance technology will rely on artificial intelligence in the future – ELE Times

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Over 40% of privacy compliance technology will rely on artificial intelligence (AI) by 2023, up from 5% today, according to Gartner, Inc. Privacy laws, such as General Data Protection Regulation (GDPR), presented a compelling business case for privacy compliance and inspired many other jurisdictions worldwide to follow, said Bart Willemsen, research vice president at Gartner.

More than 60 jurisdictions around the world have proposed or are drafting postmodern privacy and data protection laws as a result. Canada, for example, is looking to modernize their Personal Information Protection and Electronic Documents Act (PIPEDA), in part to maintain the adequacy standing with the EU post-GDPR.

Privacy leaders are under pressure to ensure that all personal data processed is brought in scope and under control, which is difficult and expensive to manage without technology aid. This is where the use of AI-powered applications that reduce administrative burdens and manual workloads come in.

AI-Powered Privacy Technology Lessens Compliance Headaches

At the forefront of a positive privacy user experience (UX) is the ability of an organization to promptly handle subject rights requests (SRRs). SRRs cover a defined set of rights, where individuals have the power to make requests regarding their data and organizations must respond to them in a defined time frame.

According to the 2019 Gartner Security and Risk Survey, many organizations are not capable of delivering swift and precise answers to the SRRs they receive. Two-thirds of respondents indicated it takes them two or more weeks to respond to a single SRR. Often done manually as well, the average costs of these workflows are roughly $1,400 USD, which pile up over time.

The speed and consistency by which AI-powered tools can help address large volumes of SRRs not only saves an organization excessive spend, but also repairs customer trust, said Mr. Willemsen. With the loss of customers serving as privacy leaders second highest concern, such tools will ensure that their privacy demands are met.

Global Privacy Spending on Compliance Tooling Will Rise to $8 Billion Through 2022

Through 2022, privacy-driven spending on compliance tooling will rise to $8 billion worldwide. Gartner expects privacy spending to impact connected stakeholders purchasing strategies, including those of CIOs, CDOs and CMOs. Todays post-GDPR era demands a wide array of technological capabilities, well beyond the standard Excel sheets of the past, said Mr. Willemsen.

The privacy-driven technology market is still emerging, said Mr. Willemsen. What is certain is that privacy, as a conscious and deliberate discipline, will play a considerable role in how and why vendors develop their products. As AI turbocharges privacy readiness by assisting organizations in areas like SRR management and data discovery, well start to see more AI capabilities offered by service providers.

For more information, visit http://www.gartner.com

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Tesla Is Building Its First European Factory But It Has to Clear a Forest First – Singularity Hub

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Tesla is having a banner year, and were not even two months in. After reaching what was an all-time high in December at a value of $393.15 per share, last Wednesday the companys stock closed at more than double that: $917.42 per share.

While its car sales are strong, theyre not the source of Teslas skyrocketing value; people are investing in the company because they see it as the future of electric vehicles. After clearing a legal hurdle last week, Tesla is set for more growth, and in a brand-new market: Europe. Germany, to be specific.

CEO Elon Musk announced plans last November to build a fourth Gigafactory outside Berlin (the first three are in Nevada, New York, and Shanghai). But construction involves cutting down a pine forest the size of 100 soccer fields (not to mention removing buried World War II ammunition), and work was halted after local environmental groups protested. On top of having to cut down thousands of trees, the factory will border a nature reserve, and theres been much concern raised about how the areas water supply and wildlife will be impacted.

A Berlin-Brandenburg court stopped Teslas forest-clearing with an injunction earlier this month, but last Thursday overturned the injunction and granted the company permission to resume activity, finding that the legal requirements for early construction had been met.

The factory will be located in Gruenheide, a small town about 33 kilometers (20 miles) south-east of Berlin. Tesla intends to have the plant completed and fully functional by mid-2021, and will eventually produce up to 500,000 cars a year there. Though its moving forward with land-clearing and other construction preparations, the company technically doesnt have final project approval from German authorities. Tesla has projected that the factory will employ about 12,000 people.

Getting the state governments approval is just one of a few hurdles left to clear, and in fact may be more straightforward than the other tasks awaiting Tesla as it builds this factory.

German environmental laws dictate that construction must not interfere with the breeding period for wildlife, which starts in March; this essentially means that for the project to move forward on its planned timetable, tree-cutting would need to be completed in the next couple weeks.

Speaking of protecting wildlife, Tesla will also have to provide bats living in the forest with alternative spots to hibernate, put up fences to prevent reptiles from entering the area, relocate ant nests without destroying them, and find a way to humanely expel any wolves living in the area.

In a tweet from January 24, Musk emphasized that the factory will absolutely be designed with sustainability and the environment in mind. He added that Tesla will plant three trees for every tree it cuts down in the area.

Home to iconic brands like BMW, Mercedes, Audi, and Volkswagen, German car manufacturing has been disrupted by companies that got an earlier and stronger start in electric vehicle technologyspecifically, Tesla. The companys Model 3 outsold all German competitors in both the US and European markets last year, and Germanys auto industry is now at a 22-year low.

The arrival of Tesla will, in the best-case scenario for German automakers, spur innovation through competition and encourage more private-sector investment. The Germans may not be leaders in electrification, but they certainly have a reputation for high-quality engineering. They would do well to follow in Teslas footsteps and start investing in energy storage technology and research; perhaps this could be the path to a rejuvenated German auto industry and economy.

But first, lets make sure those bats, wolves, lizards, birds, and ants are taken care of.

Image Credit: Artist rendering, Gigafactory. Image courtesy of Tesla

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AI Just Discovered a New Antibiotic to Kill the World’s Nastiest Bacteria – Singularity Hub

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Penicillin, one of the greatest discoveries in the history of medicine, was a product of chance.

After returning from summer vacation in September 1928, bacteriologist Alexander Fleming found a colony of bacteria hed left in his London lab had sprouted a fungus. Curiously, wherever the bacteria contacted the fungus, their cell walls broke down and they died. Fleming guessed the fungus was secreting something lethal to the bacteriaand the rest is history.

Flemings discovery of penicillin and its later isolation, synthesis, and scaling in the 1940s released a flood of antibiotic discoveries in the next few decades. Bacteria and fungi had been waging an ancient war against each other, and the weapons theyd evolved over eons turned out to be humanitys best defense against bacterial infection and disease.

In recent decades, however, the flood of new antibiotics has slowed to a trickle.

Their development is uneconomical for drug companies, and the low-hanging fruit has long been picked. Were now facing the emergence of strains of super bacteria resistant to one or more antibiotics and an aging arsenal to fight them with. Gone unchallenged, an estimated 700,000 deaths worldwide due to drug resistance could rise to as many as 10 million in 2050.

Increasingly, scientists warn the tide is turning, and we need a new strategy to keep pace with the remarkably quick and boundlessly creative tactics of bacterial evolution.

But where the golden age of antibiotics was sparked by serendipity, human intelligence, and natural molecular weapons, its sequel may lean on the uncanny eye of artificial intelligence to screen millions of compoundsand even design new onesin search of the next penicillin.

In a paper published this week in the journal, Cell, MIT researchers took a step in this direction. The team says their machine learning algorithm discovered a powerful new antibiotic.

Named for the AI in 2001: A Space Odyssey, the antibiotic, halicin, successfully wiped out dozens of bacterial strains, including some of the most dangerous drug-resistant bacteria on the World Health Organizations most wanted list. In a monthlong experiment, E. coli bacteria also failed to develop resistance to halicin, in stark contrast to existing antibiotic ciprofloxacin.

In terms of antibiotic discovery, this is absolutely a first, Regina Barzilay, a senior author on the study and computer science professor at MIT, told The Guardian.

The algorithm that discovered halicin was trained on the molecular features of 2,500 compounds. Nearly half were FDA-approved drugs, and another 800 naturally occurring. The researchers specifically tuned the algorithm to look for molecules with antibiotic properties but whose structures would differ from existing antibiotics (as halicins does). Using another machine learning program, they screened the results for those likely to be safe for humans.

Early study suggests halicin attacks the bacterias cell membranes, disrupting their ability to produce energy. Protecting the cell membrane from halicin might take more than one or two genetic mutations, which could account for its impressive ability to prevent resistance.

I think this is one of the more powerful antibiotics that has been discovered to date, James Collins, an MIT professor of bioengineering and senior author told The Guardian. It has remarkable activity against a broad range of antibiotic-resistant pathogens.

Beyond tests in petri-dish bacterial colonies, the team also tested halicin in mice. The antibiotic cleared up infections of a strain of bacteria resistant to all known antibiotics in a day. The team plans further study in partnership with a pharmaceutical company or nonprofit, and they hope to eventually prove it safe and effective for use in humans.

This last bit remains the trickiest step, given the cost of getting a new drug approved. But Collins hopes algorithms like theirs will help. We could dramatically reduce the cost required to get through clinical trials, he told the Financial Times.

The bigger story may be what happens next.

How many novel antibiotics await discovery, and how far can AI screening take us? The initial 6,000 compounds scanned by Barzilay and Collinss team is a drop in the bucket.

Theyve already begun digging deeper by setting the algorithm loose on 100 million molecules from an online library of 1.5 billion compounds called the ZINC15 database. This first search took three days and turned up 23 more candidates that, like halicin, differ structurally from existing antibiotics and may be safe for humans. Two of thesewhich the team will study furtherappear to be especially powerful.

Even more ambitiously, Barzilay hopes the approach can find or even design novel antibiotics that kill bad bacteria with alacrity while sparing the good guys. In this way, a round of antibiotics would cure whatever ails you without taking out your whole gut microbiome in the process.

All this is part of a larger movement to use machine learning algorithms in the long, expensive process of drug discovery. Other players in the area are also training AI on the vast possibility space of drug-like compounds. Last fall, one of the leaders in the area, Insilico, was challenged by a partner to see just how fast their method could do the job. The company turned out a new a proof-of-concept drug candidate in only 46 days.

The field is still developing, however, and it has yet to be seen exactly how valuable these approaches will be in practice. Barzilay is optimistic though.

There is still a question of whether machine-learning tools are really doing something intelligent in healthcare, and how we can develop them to be workhorses in the pharmaceuticals industry, she said. This shows how far you can adapt this tool.

Image Credit: Halicin (top row) prevented the development of antibiotic resistance in E. coli, while ciprofloxacin (bottom row) did not. Collins Lab at MIT

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Rhythm and Rhyme – Oxford American

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Artist: Rob Brown

Project: Dont Bow Down on that Dirty Ground: The Mardi Gras Indians of New Orleans

Description:With an anthropologists dedication to understanding a distinct subculture, Rob Brown has spent two decades working among the New Orleans Mardi Gras Indians, whose ceremonial dress, mysterious vernacular idioms, a song canon of complex rhythm and rhyme, [and] unique style of dance and movement, according to Brown, constitute a folk group that has maintained its cultural richness and singularity for more than a century.

Ostrich plumes and intricate beadwork adorn the participants handmade suits as they take to the streets in a parade unlike any other in the city. Documenting the unique traditions of the Uptown neighborhoods, Brown captures the lively atmosphere of masking on Mardi Gras.

Eyes on the Southis curated byJeff Rich. The weekly series features selections of current work from Southern artists, or artists whose photography concerns the South. To submit your work to the series, This email address is being protected from spambots. You need JavaScript enabled to view it..

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Review: ‘Once Were Brothers: Robbie Robertson and the Band’ – Los Angeles Times

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Its Bruce Springsteen who says it best: It was like youd never heard them before and like theyd always been there forever and ever.

Springsteen is talking about the Band, a dazzling group that for a brief period in the late 1960s used a combination of rock, country and blues to jump start the Americana sound and set the popular music world on its ear. Then, seemingly just as suddenly, they were gone.

The story of the rise and disintegration of the Band turns out to be as compelling as its spectacular music, and its good to have the tale told and the groups formidable sounds heard one more time, in the documentary Once Were Brothers: Robbie Robertson and the Band, directed by Daniel Roher.

As the title indicates, this is the groups story from the point of view of Robertson, its most prolific songwriter and the man whose post-Band career has been the most noteworthy, and while that situation is inevitable, its not quite ideal.

Inevitable because not only is Robertson the band member most comfortable with what Joni Mitchell called the star maker machinery behind the popular song, but three of his band mates (Rick Danko, Levon Helm and Richard Manuel) have died, and the fourth, Garth Hudson, is very much not comfortable in the public eye.

But though he is in effect the last man standing, Robertson and his comrades did not see eye to eye toward the end, and though Brothers acknowledges that situation, giving him pride of place invariably unbalances the film.

Add to that the not surprising deference the 25-year-old director shows to a 76-year-old superstar with a willingness to self-mythologize, and regretting that the other Band members could not be seen and heard more than they are in archival interview clips is unavoidable.`

But it is a measure of the singularity of the Bands story, and the way their music remains such a tonic to experience, that Brothers still demands to be seen.

Just watching and listening to the group tearing through their classic Up on Cripple Creek near the documentarys opening, alive with the pleasure of making great music with one another, is enough to joyously lift you out of your seat.

Because Once Were Brothers also functions as a Robertson biography, we begin with tales of his Toronto background as the child of a mother born on the Six Nations Reserve in Ontario and a Jewish gambler who died before he was born.

Rock music captivated Robertson, and when he was 15 his band opened in Toronto for the wild and crazy rockabilly group Ronnie Hawkins and the Hawks.

At age 16, he took a train by himself to Fayetteville, Ark., and joined the group, becoming fast friends with the groups drummer and fellow teen, Levon Helm.

Under their influence, Hawkins hired three other Canadian youths Danko, Hudson and Manuel and the group was soon playing in bars they were too young to patronize.

More than that, as Hawkins, at age 85 one of the films most engaging interviews, avows, playing together the five Hawks shot past me musically like a bolt of lightning.

The group took a leap forward in visibility when it came to the attention of Bob Dylan and became the band that backed him and faced hostile crowds on the infamous Going Electric tours, leading Dylan, interviewed briefly here, to call them gallant knights standing behind me.

When Dylan ended up moving to Woodstock, the group followed and even persuaded Helm, whod left during the Dylan tour, to join them in a brightly painted house that became iconic when the group, having decided to call itself the Band, released Music From Big Pink in 1968.

What happened next, involving great musical success, drinking, serious car crashes and the inevitable hard drug use, is so complex and so frenetic you almost wish Brothers had the length of a limited series to deal with it all.

At a certain point Robertson, alone among the group to have married and started a family (former wife Dominique is spoken to) began to get bigger ideas. He went out to Los Angeles, took meetings with David Geffen, moved to Malibu (as did Dylan and other Band members) and became friendly with Martin Scorsese.

The Last Waltz, the concert and Scorsese film commemorating the official end of the Band in its original incarnation, was apparently Robertsons idea, and the rest of the gang did not necessarily love it.

Soon to come were disputes, referred to briefly in the film, over who should be getting songwriting credit and the royalties that went with it, and its sad to watch the wheels falling off this once glorious enterprise. As Robertson himself puts it, it was such a beautiful thing, and it went up in flames.

'Once Were Brothers: Robbie Robertson and the Band'

Running time: 1 hour, 42 minutes

Playing: Starts Feb. 21, Arclight Hollywood; The Landmark, West Los Angeles

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Review: 'Once Were Brothers: Robbie Robertson and the Band' - Los Angeles Times

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T’s Spring Women’s Fashion Issue: The Test – The New York Times

Posted: at 2:13 am

Although there are many things I miss about being young (all of them too obvious to detail here), one thing I dont is the hyperawareness of age. When you are young and ambitious, your 20s can feel like a constant and unrelenting race, one in which you are vividly aware of not only your own position, but that of your peers as well. How many times did I moan about someone who seemed to be so much more accomplished than I? How much of my consciousness was dedicated to cataloging how many years (or months, even) younger or older a perceived rival was than I? I wanted to be a writer, and I wanted to be an editor in chief, and yet everyone always seemed so much further ahead of me; everyone elses pace looked so much brisker, their triumph so much more assured.

Anyone who is reading this and in a similar position should take heart, however: At some point, those feelings will fade. You will realize that early professional success ensures nothing. You will also realize that the most important thing is not that you were first to accomplish something, but that you did so on your own terms, with as few compromises as possible. By this time, youll probably be nearing or in middle age, but the consolation prize for being in your 40s is the relief youll feel that, despite everything, you are free from that particular tyranny.

The ticking clock is, Id venture, louder still for those of us living (or attempting to live) a creative life. We celebrate savants, prodigies, early promise. Your first gallery show, your first stage role, your first published book, your first runway collection these are laudable moments; they happen for so few, and they should be celebrated. But its after the show closes or the curtain falls that the second test begins the one in which you have to prove to yourself not just that you can produce art, but that you can be an artist. This test will consume the rest of your life, and although there will be moments of joy, the pursuit will often be lonely and mapless. Your age will not matter in this test; what will instead is your resilience, your durability and the singularity of your vision.

There are probably few fashion designers who understand this as vividly as Marc Jacobs. Jacobs was 29 and the creative director of Perry Ellis when he presented his infamous grunge collection, which made him an instant sensation. Now 56, he has been famous and an artistic director for almost half of his life. Over the course of his long career, he has been responsible for giving shape and relevance to American luxury; for transforming the business of fashion; for changing our perception of what an artistic director looks like and what a runway show can be. Of course, there have been disappointments as well: both professional and personal. And yet what I admire most about him is his constant vulnerability, the generosity of his imagination, his lack of cynicism, the wonder hes able to make his audience feel. To see one of Jacobss shows is to witness the work of someone who has never become weary of creating, who knows as all artists do that every beginning is another chance to make the world anew. He is a reminder to all of us seeking to live a creative life that trying something different is not only not a bad thing, it is an imperative.

So dont waste your time tracking who got there first, young artists. There is no stopwatch. What there is, finally, is you and a blank canvas, whether that canvas is a literal one, or whether it takes the form of a notebook or computer screen or rehearsal space or dress form. All you have to do is start. All you have to do is never stop.

Read more from Ts Feb. 23 Womens Fashion issue.

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T's Spring Women's Fashion Issue: The Test - The New York Times

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