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Daily Archives: January 23, 2020
‘Second Amendment Sanctuaries’ are the Right’s new gun push – Uniontown Herald Standard
Posted: January 23, 2020 at 8:44 am
When one of the Pennsylvania Legislatures most conservative members announced her desire to pass Second Amendment Sanctuary ordinances that defy state and federal gun laws, the temptation at first was to laugh and shake your head in disbelief.
In barely a year in the state House, Rep. Stephanie Borowicz, a Republican who hails from rural Clinton County, has proven to be anything but shy when it comes to courting controversy. So when Borowicz dropped her press release on Second Amendment Sanctuaries, it barely registered as a ripple on Twitter.
But as The Trace, a site that tracks gun violence-reduction efforts reports, theres plenty of reason to pay attention. Thats because Borowicz has quietly inserted herself into a movement that stretches across more than 400 municipalities in 20 states.
If the term Second Amendment Sanctuary, sounds familiar, theres a reason for that. As The Trace reports, backers purposefully modeled them on so-called Sanctuary Cities, where local officials decline to cooperate with federal immigration authorities.
Were just stealing the language that sanctuary cities use, Bryan Kibler, the states attorney in Effingham County, Illinois, told the Associated Press in 2018, according to The Trace.
The county approved its own gun sanctuary in April 2018, according to published reports, saying gun laws then under consideration by the Illinois General Assembly were unconstitutionally broad.
As The Daily Item of Sunbury, Pa., reported earlier this month, the state branch of a group called Gun Owners of America has volunteers working statewide on such ordinances. Officials in Bradford County, along the New York State border enacted such a resolution last December. Another northeastern Pennsylvania municipality is reportedly considering its own resolution.
In her statement, Borowicz said she was expressing my complete support for efforts in two counties in her district to protect law-abiding residents against unconstitutional gun control laws imposed in Harrisburg or Washington, D.C.
Among those measures are a proposed red flag law now before the Legislature that would allow police, acting on a court-order, to temporarily seize someones weapons if they believe they pose an immediate threat to themselves or to public safety.
These extreme risk protection order laws, as theyre formally known have been shown in other states to have reduced gun crimes and suicide.
While legal experts and others believe Second Amendment Sanctuaries are mostly symbolic and not legally binding, others say that they could lead to expensive litigation for local governments that decline to enforce state and federal gun laws.
To the extent that police chiefs and especially prosecutors view these actions by local governments as reflections of widespread community sentiment, they may feel more comfortable in adjusting their own exercise of discretion in making arrests and in charging decisions, George Mason University law professor Nelson Lund told The Daily Item. At least in that sense, it is probably not accurate to characterize them as mere publicity stunts.
Ultimately, the final battle over these local ordinances will be waged in the courts.
The proper procedure if law enforcement officers and local governments have issue with new laws is to bring legal action in the courts, and have courts determine whether those laws are constitutional, Jonathan Lowy, the vice president of the legal action project at the gun reform group Brady, told The Trace.
There is no small irony here that the very legislators and officials pursuing these sanctuary protections are those who kick back the hardest when local officials, tired of federal and state-level inaction on gun violence-reduction issues, move to enact ordinances stronger than those in existing federal law.
Such was the case when officials in Pittsburgh enacted tough local ordinances in the wake of a murderous spree at the Tree of Life Synagogue in 2018 that claimed the lives of 11 people.
Pennsylvania state Rep. Daryl Metcalfe, a Republican and outspoken gun-rights activist, called for Pittsburgh Mayor Bill Pedutos impeachment as a result.
Republicans already have an image problem with voters when it comes to gun issues. Theyll have even more explaining to do when a mass shooting erupts in one of their Second Amendment paradises.
An award-winning political journalist, John L. Micek is Editor-in-Chief of The Pennsylvania Capital-Star in Harrisburg and former Opinion Editor and Political Columnist at PennLive/The Patriot-News. Email him at jmicek@penncapital-star.com and follow him on Twitter @ByJohnLMicek.
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Ft. Gay, West Virginia becomes first Second Amendment sanctuary town in the state – WVNS-TV
Posted: at 8:44 am
Posted: Jan 20, 2020 / 06:20 AM EST / Updated: Jan 20, 2020 / 06:22 AM EST
FT. GAY, W.Va. (WOWK) On Friday, January 17, Ft. Gay, West Virginia became the first town in the state to declare itself a sanctuary for the Second Amendment.
Mayor Joetta Hatfield said, The members of the town council are proud to be the first municipality in West Virginia to adopt an ordinance that formally establishes Ft. Gay as a sanctuary against any attempt by legislators or members of Congress to infringe the Second Amendment rights of Ft. Gays citizens.
Mayor Hatfield also said that the council was motivated by the recent fall of the Commonwealth of Virginia, of which West Virginia was once a part, into the hands of those now rushing to strip away the constitutional right to bear arms.
Earlier in the week West Virginias Putnam County became a sanctuary county for the Second Amendment when its county commission voted to pass the measure.
Ft. Gay is located in Wayne County. Allen Whitt, Republican candidate for the U.S. Senate, attended the historic vote in Ft. Gay; which is located on the Kentucky border about 20 miles south of Huntington, West Virginia. Whitt said, Tonight was one of the many reasons Im proud to be a West Virginian.
The Ft. Gay council members made a bold statement that will defend their citizens constitutional rights to legally own firearms. Town council members said becoming a sanctuary city will protect against efforts by legislators pushing red flag gun laws.
Im running for the U.S. Senate because our current Senator Shelley Moore Capito says red flag gun laws make sense to her. Well they certainly shouldnt make sense to anyone who has vowed to support the U.S. Constitution, but on May 12th, a vote for Allen Whitt for U.S. Senate will make sense for gun owners and hunters.
Red flag laws strip gun owners from due process if someone calls and raises a red flag of concern about the owner. Their guns could be confiscated with no evidence of wrongdoing based on a fraudulent complaint.
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Ft. Gay, West Virginia becomes first Second Amendment sanctuary town in the state - WVNS-TV
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Lawrence County, Ohio, joins ranks of counties declaring themselves ‘Second Amendment sanctuaries’ – Huntington Herald Dispatch
Posted: at 8:44 am
COAL GROVE, Ohio Joining other communities around the Tri-State, the Lawrence County Board of Commissioners adopted a resolution declaring Lawrence County as a Second Amendment sanctuary.
Officials in Boyd, Greenup, Lawrence and Pike counties in Kentucky have adopted a similar, non-binding resolution and Cabell County is considering a similar measure after Putnam County became the first West Virginia county to pass such a resolution.
The non-binding, symbolic resolution says that the three Republican commissioners declared their intent to oppose any unlawful infringement on the rights of law-abiding citizens to keep and bear arms using such legal means as may be expedient including, without limitation, court action.
The board was asked last week to consider the resolution by the local chapter of the National Wild Turkey Federation.
It is always the desire of this board to abide by Ohio law, ordinances or statutes, said Commission President DeAnna Holliday. As a member of the Wild Turkey Federation, Im honored to know that hundreds of members who believe in the rights of hunting individuals in our county and state join me in support of this resolution.
As a gun owner, I hope others will recognize this is not an attempt to legislate or dictate to you as to what we intend, Holliday said. We stand today to send a signal to all that we believe the 2nd Amendment gives us the constitutional right to own firearms without any impedance.
Finally, as a wife, mother and grandmother, I hereby declare that we have the right of self-protection, she said. As women, we do not necessarily have to turn to a man for protection. We have the constitutional right to protect ourselves and our family with a firearm.
Commissioners Colton Copley and Freddie Hayes Jr. also voted for the resolution.
It doesnt cost any money to do this, Hayes said. There is no cost to taxpayers.
The board also received and filed a request by Joseph Benning of the Symmes Creek Restoration Committee to seek state funding for signs at several locations in the county. The exact locations will be determined before the grant request is sent to the Ohio Department of Natural Resources, Benning said.
In other action, the board:
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Lawrence County, Ohio, joins ranks of counties declaring themselves 'Second Amendment sanctuaries' - Huntington Herald Dispatch
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Were afraid theyll take our guns, N.J.’s newest 2nd Amendment town says – NJ.com
Posted: at 8:44 am
Another New Jersey municipality has adopted a pro-Second Amendment resolution, following a lengthy debate touching on gun laws, domestic violence, self-defense, misinformation and even a reference to weapons restrictions in Nazi Germany.
The Stillwater Township Committee adopted a resolution declaring Stillwater a Second Amendment / Lawful Gun Owner Township" on Tuesday night, but not everyone in the room was cheering.
Some in the audience of more than 60 spoke in opposition to the resolution, which does not supersede any state or federal laws, before it was approved in a 3-1 vote.
It resembled resolutions passed in at least seven other New Jersey municipalities since December.
Stillwater Mayor Lisa Chammings cast the lone dissenting vote, stating that while she supports the Second Amendment she was not comfortable with the part of the resolution claiming that red flag laws - statutes that allow for removing weapons from someone judged a threat to themselves or others - had been "misapplied and misused and run afoul of the U.S. Constitution.
I know the amount of domestic violence this township went through, Chammings, whose late father was Stillwaters last police chief, told the audience from the dais.
She also alluded to the suicide of a police officer.
The governing body in Stillwater, located in Sussex County, undertook the resolution at the behest of Assemblyman Parker Space, R-24th District, who voted against New Jerseys 4-month-old red flag law. The four committee members who voted Tuesday are Republicans.
Space spoke several times during Tuesdays meeting. He outlined a hypothetical confrontation involving Stillwater committee member Vera Rumsey in asserting that New Jerseys red flag law could facilitate a false allegation against him.
With red flag laws, we can sit down and have coffee - Vera and I, or Committeewoman Rumsey, and we could be talking about different things and she could feel - maybe, He was talking about Donald Trump and I dont like him, and I felt kind of threatened by what he had to say, and then she could, in return, report me, and then pretty soon theyre coming to my door, taking my firearms away, Space said.
Space, though, was describing a different process than exists under New Jerseys red flag law, formally known as the Extreme Risk Protective Order Act of 2018.
It allows for a judge in response to a request from family or household members, or law enforcement to order the removal of guns and ammunition from someone who poses a significant danger of bodily injury to self or others, as described in the statute.
The legislation received crossover support from many Republicans, passing the Senate by 32-5 and Assembly by 59-12. At least 17 other states have similar laws, including Florida, where Space at one point acknowledged owning property.
Some in the audience who spoke in support of the resolution, though, appeared to pick up on the idea that the red flag law, and others, are simply a pretense for seizing weapons. There was applause when one speaker drew a parallel to gun restrictions under the Nazis in Germany.
Kathleen Marshall, who spoke in opposition to the resolution, expressed dismay at the outcome.
Im heartbroken, Marshall, a Stillwater resident since 1992, told NJ Advance Media.
I love my town. I think theres a lot of misinformation and ignorance about what the actual laws are. They go right to, theyre taking our guns away, and thats not what this is about, Marshall said.
Kathleen Marshall, a Stillwater resident who addressed the township committee in opposition to the resolution, remains at the meeting following the vote, Jan. 21, 2020Rob Jennings / NJ Advance Media for NJ.com
After Donna Price, a Stillwater resident, spoke in opposition to the resolution and disagreed with Spaces characterization of red flag laws, a man in the audience asked her if she felt threatened by him.
I do, Price said.
In response, the man responded, perhaps facetiously, that Space might get in trouble as a result.
You just got red-flagged, the man said.
Tuesdays meeting, while at times tense, remained civil. Every seat in the room, which has a maximum capacity of 55, was taken, and there appeared to be up to two dozen others standing along the side and back walls and just outside the door.
Kaitlyn Hammerle, a Stillwater resident, spoke in support of the resolution.
All it is saying is that Stillwater respects and supports the lawfully abiding gun ownership of all the residents. It avoids using the word sanctuary, which could be misconstrued as allowing illegal firearms," Hammerle said in a reference to a version of the resolution adopted in West Milford and, last week, by the Cape May County freeholder board.
Mike Vrabel of Sparta spoke in opposition. He said the current laws do not violate the rights of law-abiding gun owners and refuted assertions from Second Amendment advocates that increasing access to guns would save lives.
Vrabel, a U.S. Air Force veteran, alluded to a friendly-fire incident in 1989 in Panama, that he witnessed, that claimed the life of a 19-year-old Army Ranger.
As far as the good guy with a gun theory, I understand the emotional appeal of that, said Vrabel, a member of the Sussex County chapter of Brady formerly the Brady Campaign to Prevent Gun Violence.
Ask yourself, if an incident happens, and you are armed, and you have your concealed carry permit which I know is almost impossible in New Jersey are you up to the task, because even an Army Ranger can falter, Vrabel said.
As he concluded, someone from the audience shouted, How many people were saved in Texas - a reference to a gunman at a Texas church who was fatally shot by another church member Dec. 29, but not before the gunman killed two people inside the building.
Votes in additional places seem likely. Space has asked municipalities in Sussex and Warren counties, along with both freeholder boards, to consider pro-Second Amendment resolutions.
Two Sussex County freeholders, board director Sylvia Petillo and Herb Yardley, attended Tuesdays meeting but did not address the Stillwater committee.
Assemblyman Parker Space, R-24th District, in hat, with Sussex County Freeholder Herbert Yardley at the township committee meeting in Stillwater, Jan. 21, 2020Rob Jennings / NJ Advance Media for NJ.com
In contrast with the mayor, George Scott, the townships deputy mayor, offered unambiguous support for the totality of the resolution.
Im concerned that theyre going to come in and take my guns, Scott said.
Chammings, while stating her support for the Second Amendment, said she could not back the resolution without hearings specific problems regarding red flag laws.
I dont know how its being misused or misapplied, she told NJ Advance Media following the vote, in quoting back the part of the resolution that gave her pause.
Stillwater is home to about 3,900.
Rob Jennings may be reached at rjennings@njadvancemedia.com. Follow him on Twitter@RobJenningsNJ. Find NJ.com on Facebook.
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Washington County Fiscal Court to take up 2nd Amendment resolution again – The Springfield Sun
Posted: at 8:44 am
Editor's note: The story below has been edited to correct an error in the story that appeared in the Jan. 22 print edition of The Sun. Kentucky United spokesperson Sean Hall met with Washington County Judge-Executive Timothy Graves to review a proposed resolution, not County Attorney Bill Robinson. A correction will appear in the Jan. 29 edition of The Sun.
Update: Since this story went to press, the Nelson County Fiscal Court voted to pass a resolution in support of the Second Amendment.
A group that has pressured county governments across Kentucky to take action regarding the Second Amendment has set its sights on Washington County, resulting in the fiscal court planning to take up the issue for the second time Friday.
Magistrates heard comments at their Jan. 13 meeting, at which time County Judge-Executive Timothy Graves stated passing a resolution presented to the court by the group would be an illegal act.
Washington County Attorney Bill Robinson cited a Kentucky law that states local governments can make no ordinance in relation to the Second Amendment or gun issues in general.
The cited law says any action in regards to gun control is null and void and unenforceable.
Robinson said additionally, the county, the fiscal court, and individual magistrates would be subject to civil and criminal penalties if they took action of any kind.
But Graves said the matter did not die.
Following that meeting, the county attorney went to work drafting something we could act on, he said. He looked at what other counties are passing and how they worded it.
And Kentucky United did not give up. Members presented a second resolution to the fiscal court.
Bill (Robinson) looked it over and took some of the verbiage from it and merged that with the resolution he was drafting, Graves said. We believe we have come up with a resolution that we can pass that meets the desires of the group but does not put us in a position where we would be legally liable.
Sean Hall, a spokesperson for Kentucky United-Washington County, met with Graves over the weekend and was allowed to review the revised resolution.
Overall, Im OK with the new resolution, he said. Theres a little give and take to find something we can both agree on.
Hall said he posted the revised resolution for the group to review and the response has been pretty positive.
He said the resolution doesnt identify red flag laws directly but does cover what is included in those laws.
Hall said last Monday was the first time he and most of the other people who came to address the fiscal court had attended such an assembly and certainly had never participated in public meetings.
We thought there would be more discussion and a dialogue between us and the magistrates, he said.
Hall went on to say many of those in attendance felt their voices were not heard.
"The decision had been made before we got there," he said. "We were very unhappy when we left the courthouse on Monday.
Some members of Kentucky United took to Facebook to express their frustration at Washington County not taking action Jan. 13.
A member with the Facebook profile name Curry Haydon posted, Its an absolute shame that Washington county did not pass this, disappointed in my county is an understatement.
On a Facebook page called Washington County United, someone with the profile name Craig Settled posted, Man I hope WC fiscal court can educate themselves very quickly or well they are gonna have a 4 year stint in their elected positions. This is way more important than a certain road getting blacktopped and that magistrate lost his elected position. I wish them luck but if they need help I say some of the counties around them will help educate them and lend them a spine. Its funny how words are holding this up. I mean come on it dont take someone with that much education to re-write something. How hard is that?? If it thats hard get a English teacher to help them. No need of being scared because if youre scared then step out of the way and let the big boys and girls do the job.
Someone with the profile name C.D. Wandle said, Shame on our elected officials spineless,gutless,money handlers, and a profile with the name Papaw Baker posted, We need to make this a one term judge executive.
Kentucky United members have been the driving force behind a recent, so far unsuccessful, push to have a Second Amendment resolution passed in neighboring Nelson County. (Group members have said they will not support a compromise resolution proposed.)
Neighboring Marion and Boyle counties have both passed resolutions.
Hall said at the fiscal court's Jan. 13 meeting that Kentucky United is concerned about bills proposed in Virginia, and concerned that similar legislation could be passed in Kentucky.
Protesters spent Martin Luther King Jr. Day in Virginia's capital city protesting, many armed.
According to at least one post on the Kentucky United Facebook page, the protests are just the beginning.
Guys its happening the Governor of the state of Virginia has called a state of emergency starting Friday evening due to the threat of violence over our second amendment rights this is the tip of the iceberg, states a post by someone whose profile name is Mike Perraut.
Graves said his office had received a lot of feedback following the fiscal courts Jan. 13 meeting.
This is a hot-topic issue, he said, People are very passionate and vocal on both sides. We think we have come up with a resolution that provides a happy medium. And again, we want to do what is legal.
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Washington County Fiscal Court to take up 2nd Amendment resolution again - The Springfield Sun
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President Trump: Second Amendment will never go unprotected – 8News
Posted: at 8:44 am
WASHINGTON, D.C. (WRIC) In a tweet posted Monday, hours after thousands rallied peacefully for gun rights in Virginia, President Donald Trump said he would never allow the Second Amendment to go unprotected.
I will NEVER allow our great Second Amendment to go unprotected, not even a little bit! President Trump wrote.
I will NEVER allow our great Second Amendment to go unprotected, not even a little bit!
The post comes hours after President Trump tweeted his disapproval with the Democratic party in Virginia for working hard to take away citizens constitutional right to bear arms in the United States.
The Democrat Party in the Great Commonwealth of Virginia are working hard to take away your 2nd Amendment rights, President Trump tweeted Monday. This is just the beginning. Dont let it happen, VOTE REPUBLICAN in 2020!
The Democrat Party in the Great Commonwealth of Virginia are working hard to take away your 2nd Amendment rights. This is just the beginning. Dont let it happen, VOTE REPUBLICAN in 2020!
On Friday, President Trump tweeted that the Second Amendment was under very serious attack in Virginia.
Thats what happens when you vote for Democrats, they will take your guns away, the president wrote. Republicans will win Virginia in 2020. Thank you Dems!
Your 2nd Amendment is under very serious attack in the Great Commonwealth of Virginia. Thats what happens when you vote for Democrats, they will take your guns away. Republicans will win Virginia in 2020. Thank you Dems!
The tweet came after Virginia Gov. Ralph Northamdeclared a state of emergencyahead of Mondays pro-gun rights rally in Richmond as a result of credible, serious threats of violence.
8News has learned a Richmond woman with a bandanna covering her face was charged after the pro-gun rally. A man was cited for trying to climb up the fire escape of the 12-story Mutual Building at 909 E. Main Street, as well.
RELATED: President Trump: Second Amendment is under very serious attack in Virginia
President Trumps proclamation comes exactly three years after he was sworn into office. Trump declared, in a tweet, unemployment was the lowest in the history of the United States while adding his presidency had seen the best poverty, youth and employment numbers, ever.
It was exactly three years ago today, January 20, 2017, that I was sworn into office. So appropriate that today is also MLK jr DAY. African-American Unemployment is the LOWEST in the history of our Country, by far. Also, best Poverty, Youth, and Employment numbers, ever. Great!
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Proteostasis Therapeutics Announces Keystone Symposia Presentation of Organoid Study from More than 300 Adult CF Patients – BioSpace
Posted: at 8:43 am
BOSTON, Jan. 22, 2020 /PRNewswire/ --Proteostasis Therapeutics, Inc.,(NASDAQ:PTI), a clinical stage biopharmaceutical company dedicated to the discovery and development of groundbreaking therapies to treat cystic fibrosis (CF) and other diseases caused by dysfunctional protein processing, today announced the presentation of results from an ex vivo study of the Company's proprietary cystic fibrosis transmembrane conductance regulator (CFTR) modulators in organoids from individuals with CF who are ineligible for the current standard of care CFTR modulator therapies due to their genotype, a population of approximately 2,300 adults in Europe alone. The results, outlined in a poster entitled "Intestinal Organoid Models as a Path for Personalized Therapy Development in Cystic Fibrosis," will be presented at the Keystone Symposia on Tissue Organoids taking place on January 19-23, 2020 in Vancouver, BC, Canada.
The study remains on track for collecting tissue samples from up to 500 CF patients with less common genotypes by the end of Q1 2020 for assaying as organoids and for testing responsiveness to investigational CFTR modulators, including Proteostasis' CFTR potentiator, corrector and amplifier, dirocaftor (DIR), posenacaftor (POS) and nesolicaftor (NES), respectively. Data from the organoid study will be used to select a subset of patients for a confirmatory clinical trial, known as the CHOICES trial (Crossover trial based on Human Organoid Individual response in CF - Efficacy Study). This organoid program is a strategic initiative funded by the European Commission, which has invited a select number of drug developers and leading researchers in CF to build a roadmap for personalized therapeutics in CF. Based on the outcome of the study, this transition from precision to personalized medicine for the treatment of CF could begin in patients with less common mutations.
The organoid study seeks to measure the ex vivo responsiveness to the PTI CFTR modulators in tissue samples collected via a rectal suction procedure. The rectal tissue is developed into an organoid or a miniaturized organ that is genetically identical to the patient donor and shares the same micro-anatomy as the organ from which they were derived. Organoid cultures frommore than370 adult CF patients have been established to date. Based on initial genotype analysis, approximately 85% of enrolled patients carry genotypes that lead to CFTR protein synthesis making them eligible for ex vivo study with DIR, POS and NES. Data from the organoid study will be used to select a subset of patients for the confirmatory CHOICES clinical trial. The poster outlining these results is available on the Company's website at proteostasis.com.
"With advancements in models such asorganoid testing used to predict the effectiveness of CFTR modulator treatments, the transition from precision to personalized medicine in this disease is an inevitability," saidGeoffrey Gilmartin, M.D., M.M.Sc., Chief Medical Officer ofProteostasis Therapeutics. "Essential to this transition is the introduction of more therapeutic options that expand the treatment choices for patients and physicians. As the only company in the HIT-CF consortium with a proprietary combination of novel CFTR modulators that have demonstrated positive Phase 2 data, we remain very enthusiastic about its progress and the translation of these results to the clinic in the CHOICES trial."
"Access to CFTR modulators in Europe is challenged by either the ineligibility of patients for approved drugs due to their genotype, or by the lack of reimbursement for approved drugs due to their high cost," saidCornelis K. van der Ent, Professor at the Department of Pediatric Pulmonology of the Wilhelmina Children's Hospital at the University Medical Center in Utrecht, the Netherlands and HIT CF Project Coordinator. "An organoid-assay-based personalized medicine approach offers the potential of a new decision-supporting technology to inform clinical decisionsand provide each patient with CFTR modulators that lead to their highest possible benefit."
CHOICES, which is expected to initiate in mid-2020, will be the first ever personalized medicine-based study in CF. Fully funded by the HIT-CF, this trial is a placebo controlled, double blind, crossover study with an 8-week treatment period and 6 months of uninterrupted dosing. The CHOICES trial will complement the MORE trial (Modulator Options to RestorE CFTR study), a global, Phase 3, randomized, placebo-controlled study in CF subjects with the common F508del homozygous mutation, which is designed to confirm the positive efficacy and tolerability results from a recently completed Phase 2 study of the Proteostasis CFTR modulator triple combination.
About HIT-CF Europe
HIT-CF Europe is a research project which aims to provide better treatment and better lives for people with cystic fibrosis (CF) and rare mutations. To achieve this, drug candidates are first tested on patient-derived organoids in qualified laboratories across Europe. Subsequently, based on the measured signal in the organoids, a smaller group of patients will be invited to participate in a clinical trial. All participating centers are part of the European Cystic Fibrosis Society Clinical Trial Network (ECFS-CTN). The project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement number 755021. For more information, visit http://www.hitcf.org.
About Proteostasis Therapeutics, Inc.
Proteostasis Therapeutics, Inc. is a clinical stage biopharmaceutical company developing small molecule therapeutics to treat cystic fibrosis and other diseases caused by dysfunctional protein processing. Headquartered in Boston, MA, the Proteostasis Therapeutics team focuses on identifying therapies that restore protein function. For more information, visit http://www.proteostasis.com.
Safe Harbor
To the extent that statements in this release are not historical facts, they are forward-looking statements reflecting the current beliefs and expectations of management made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Words such as "aim," "may," "will," "expect," "anticipate," "estimate," "intend," and similar expressions (as well as other words or expressions referencing future events, conditions or circumstances) are intended to identify forward-looking statements. Examples of forward-looking statements made in this release include, without limitation, statements regarding the potential of our proprietary combination therapies for the treatment of CF, the potential benefit to patients of our proprietary combination therapies, expected timing of patient enrollment in our clinical studies and cohorts for our clinical programs, including our planned Phase 3 programs and initiation of registrational or pivotal studies. Forward-looking statements made in this release involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by the forward-looking statements, and we, therefore cannot assure you that our plans, intentions, expectations or strategies will be attained or achieved. Such risks and uncertainties include, without limitation, the possibility final or future results from our drug candidate trials (including, without limitation, longer duration studies) do not achieve positive results or are materially and negatively different from or not indicative of the preliminary results reported by the Company (noting that these results are based on a small number of patients and small data set), uncertainties inherent in the execution and completion of clinical trials (including, without limitation, the possibility that FDA or other regulatory agency comments delay, change or do not permit trial commencement, or intended label, or the FDA or other regulatory agency requires us to run cohorts sequentially or conduct additional cohorts or pre-clinical or clinical studies), in the enrollment of CF patients in our clinical trials in a competitive clinical environment, in the timing of availability of trial data, in the results of the clinical trials, in possible adverse events from our trials, in the actions of regulatory agencies, in the endorsement, if any, by therapeutic development arms of CF patient advocacy groups (and the maintenance thereof), and those set forth in our Annual Report on Form 10-K for the year ended December 31, 2018, our Quarterly Report on Form 10-Q for the quarter ended September 30, 2019 and our other SEC filings. We assume no obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.
CONTACTS:
Investors:David Pitts / Claudia StyslingerArgot Partners212.600.1902david@argotpartners.com/ claudia@argotpartners.com
Media:David RosenArgot Partners212.600.1902david.rosen@argotpartners.com
View original content:http://www.prnewswire.com/news-releases/proteostasis-therapeutics-announces-keystone-symposia-presentation-of-organoid-study-from-more-than-300-adult-cf-patients-300990860.html
SOURCE Proteostasis Therapeutics, Inc.
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CF Industries Holdings, Inc. [CF] Analyzing the CF using Fundamentals and Trend Analysis – The Dwinnex
Posted: at 8:43 am
CF Industries Holdings, Inc. [NYSE: CF] stock went down by -3.48% or -1.54 points down from its previous closing price of $44.25. The stock reached $42.71 during the last trading session. During the course of the last 5 trading session in the week, CF share price went up during 2 out of 5 days, that way losing -5.97% in the period of the last 7 days.
CF had two major price movements with the latest trading session as the price jumped to a high of $44.32, at one point touching $41.92. The latest high is set lower that the high price recorded in the period of the last 52 weeks, set at $44.32. The 52-week high currently stands at $55.15 distance from the present share price, noting recovery 2.03% after the recent low of $38.90.
Its stock price has been found in the range of 38.90 to 55.15. This is compared to its latest closing price of $44.25.
Keep looking out for the next-scheduled quarterly financial results that this company is expected to put out, which is slated to occur on Wed 12 Feb (In 21 Days).
Now lets turn to look at profitability: with a current Operating Margin for CF Industries Holdings, Inc. [CF] sitting at +15.67 and its Gross Margin at +20.46, this companys Net Margin is now 10.40%. These metrics indicate that this company is not generating as much profit, after accounting for expenses, compared to its market peers.
This companys Return on Total Capital is 6.37, and its Return on Invested Capital has reached 8.70%. Its Return on Equity is 8.87, and its Return on Assets is 2.16. These metrics show a mixed bag, which means that this investments attractiveness can be quickly increased or decreased in the short term, depending on future updates CF financial performance.
Turning to investigate this organizations capital structure, CF Industries Holdings, Inc. [CF] has generated a Total
What about valuation? This companys Enterprise Value to EBITDA is 8.96 and its Total Debt to EBITDA Value is 3.00. The Enterprise Value to Sales for this firm is now 3.00, and its Total Debt to Enterprise Value stands at 0.28. CF Industries Holdings, Inc. [CF] has a Price to Book Ratio of 3.28, a Price to Cash Flow Ratio of 6.75 and P/E Ratio of 19.58. These metrics all suggest that CF Industries Holdings, Inc. is more likely to generate a positive ROI.
Shifting the focus to workforce efficiency, CF Industries Holdings, Inc. [CF] earns $1,476,333 for each employee under its payroll. Similarly, this companys Receivables Turnover is 15.71 and its Total Asset Turnover is 0.33. This publicly-traded organizations liquidity data is also interesting: its Quick Ratio is 1.37 and its Current Ratio is 1.81. This company, considering these metrics, has a healthy ratio between its short-term liquid assets and its short-term liabilities, making it a less risky investment.
CF Industries Holdings, Inc. [CF] has 216.30M shares outstanding, amounting to a total market cap of $9.24B. Its stock price has been found in the range of 38.90 to 55.15. At its current price, it has moved down by -22.56% from its 52-week high, and it has moved up 9.79% from its 52-week low.
This stocks Beta value is currently 1.04, which indicates that it is 2.98% more volatile that the wider market. This stocks Relative Strength Index (RSI) is at 31.90. This RSI score is good, suggesting this stock is neither overbought or oversold.
Shares of CF Industries Holdings, Inc. [CF], on the whole, present investors with both positive and negative signals. Wall Street analysts have mixed reviews when it comes to the 12-month price outlook, and this companys financials show a combination of strengths and weaknesses. Based on the price performance, this investment is somewhat risky while presenting reasonable potential for ROI.
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Global Cystic Fibrosis (CF) Therapeutics Market , Trends, Analysis, Opportunities, Share and Forecast 2017-2025 – Dagoretti News
Posted: at 8:43 am
The global cystic fibrosis therapeutics market is expected to witness significant growth during the forecast period majorly due to availability of personalized drug therapy & molecular prosthetics for the treatment of cystic fibrosis. Furthermore, raise in prevalence of cystic fibrosis and surge in awareness about cystic fibrosis across the globe boost the cystic fibrosis market trend. For instance, according to the Cystic Fibrosis Foundation Patient Registry, in the U.S. more than 30,000 people are living with cystic fibrosis and more than 70,000 worldwide.
In addition, approximately 1,000 new cases of CF are diagnosed each year and more than 75 % of people with Cystic fibrosis F are diagnosed by age 2. Moreover, increase in R&D investments made by government in the healthcare sector drives the cystic fibrosis therapeutics market growth. However, high cost of the cystic fibrosis treatment and introduction of generic drugs hinder the growth of the market. Developing nations such as countries of Asia-Pacific region are not so aware reading the cystic fibrosis diagnosis of the newborns. In various nations, new born are not tested for CF during birth and national registries are lacking in data, thereby hampering the cystic fibrosis market growth.
The global CF therapeutics market size was estimated at USD 3,920.5 million in 2018 and is expected to grow at a CAGR of 16.7% from 2018 to 2025
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Based on cystic fibrosis therapeutics market analysis, the CFTR modulators segment dominated the market in 2018 and is anticipated to continue its dominance during the forecast period. This is attributed to increased usage of these drugs for the treatment of cystic fibrosis. This segment is also estimated to grow at the fastest rate during the forecast period. Further, the introduction of CFTR drugs, Kalydeco, Orkambi and Symdeko is one such innovation. These drugs are now widely being used for the treatment of cystic fibrosis and many other CFTR drugs are under clinical trials. The main target of these drugs is to increase the life expectancy of the patients. Moreover, advances in the diagnosis and therapeutics have significantly increased the survival of patients.
Europe constitutes the highest market share in the global cystic fibrosis therapeutics market in 2018. North America is owing to the increase in incidence of cystic fibrosis. Moreover, increase in governmental support for innovation and rise in funding of projects for R&D of various cystic fibrosis drugs further fuel the market growth in this region. UK is the highest revenue contributor due to increase in prevalence of cystic fibrosis in this region. Moreover, surge in national newborn screening program in the UK propels the market growth. In addition, many companies are involved in developing drugs for individuals who do not get benefitted with CFTR drugs. However, North America is projected to grow at the highest CAGR during the forecast period.
Key players operating in cystic fibrosis therapeutic markets are Genentech, Inc., Novartis AG, Gilead Sciences, Inc., Vertex Pharmaceuticals Incorporated, AbbVie Inc., GlaxoSmithKline Plc., Johnson & Johnson, Allergan plc, Pharmaxis Ltd., and Mylan N.V.
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MC Companies Wins ‘Rookie Fundraiser Team of the Year’ by the Cystic Fibrosis Foundation For National Sponsorship Impact – PRNewswire
Posted: at 8:43 am
SCOTTSDALE, Ariz., Jan. 21, 2020 /PRNewswire/ --MC Companies San Antonio has won the Cystic Fibrosis Foundation's 'Rookie Fundraiser Team of the Year' award for their presence as a national sponsor and powerful impact at San Antonio Great Strides. Through combined efforts of their employees at The Place at Castle Hills and The Place at Oak Hills, both located in the Castle Hills neighborhood, and the MC Companies Sharing the Good Life Foundation, MC was able to build a team of 22 Great Strides Walkers and donate a total of $4,478 to the San Antonio Great Strides Walk.
MC is extremely honored by this award, but even more so by the impact they were able to make on the national stage. In 2019 MC had Great Strides walk teams in five cities, officially designating them as a National Sponsor. Throughout the course of 2019, MC Companies participated in 7 different Cystic Fibrosis walks across three states with 118 walkers, and raised an impressive $39,000. Combined with MC Companies' employee driven Sharing the Good Life Foundation donation of $63,000, MC Companies was able to donate a grand total of $100,000 the Cystic Fibrosis Foundation in 2019.
MC Companies is no stranger to the Cystic Fibrosis Foundation and is a long-time supporter of the Great Strides Walk.However, their philanthropic ambitions do not end with CF. Giving back it as the core of MC, which is why they created their employee driven Sharing the Good Life Foundation which encourages and gives employees countless opportunities to volunteer, get involved, and give back to our local communities.
2019 was an incredible year for MC's contributions to the CF community, and they have no intention of slowing down. A new year marks a new opportunity to give back and better our communities. MC is invigorated by the challenge to surpass their 2019 goals and make 2020 another landmark year in their support for the CF community.
You can donate to our 2020 walk teams and learn more about MC's efforts by visiting the MC Companies Great Strides National Team Page. Find MC at these 2020 Great Strides walks.
Build your walk team, find and join other walk teams, and learn how you can get involved at the Cystic Fibrosis Foundation Great Strides website.
About MC Companies: MC Companies http://www.mccompanies.com is a real estate investment, development, construction, and management company specializing in the multifamily properties and commercial markets. MC Companies has completed over $750 million in multi-family and commercial value-added transactions since 1985.
Photos:https://www.prlog.org/12806931
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