Daily Archives: December 16, 2019

Art Forgery Is Easier Than Ever, and It’s a Great Way to Launder Money – VICE

Posted: December 16, 2019 at 6:42 am

This article originally appeared on VICE US.

John Myatt felt like his life was in free-fall.

It was the mid-1980s and at 41, he was a working painter who never made a splashor a profitin the London gallery scene. His wife left him, and he struggled to provide for his two young children.

So, he began to forge paintings.

Partnering with art dealer John Drewe, the duo sold more than an estimated 200 fraudulent pieces of art for millions of pounds, ensnaring some of the world's most prestigious collectors, galleries, auction houses, and storied institutions, including London's Tate Gallery.

It was one of the greatest art scandals of all time. Myatt spent countless hours making incredibly detailed "new" works in the style of Marc Chagall, Le Corbusier, Alberto Giacometti, Matisse, and Graham Sutherland, among others. He often scoured flea markets for paints, brushes, and canvases from an artist's time period, in addition to obsessively studying their techniques.

He acknowledges his skill as a forger, but says that much of pulling off the con was "about manipulating the publicity machine or just being in the right place at the right time" in making a sale; promoting the fake story of the creation of the image and how it fit into an artist's body of work; and explaining how the piece had changed hands over the years.

Myatt, who served prison time and is now living and working as a painter in the United Kingdom, is among the handful of art forgers who say the very environment in which their past crimes flourished is, in many respects, just as fertile now. As art prices hit stratospheric highs and Trump-era momentum to regulate anything reaches record lows, the art world continues to be an under-explored haven for illicit activity, that often hangs, literally, in plain sight.

"I think it's just as easy today," Myatt said of forgery in a phone interview.

John Myatt in his studio in London | Photo by Wendy Huynh

What is often dismissed as a largely victimless crime befitting of The Thomas Crown Affair (the one starring Pierce Brosnan and Rene Russo, not Steve McQueen and Faye Dunaway) may carry far higher stakes. Art forgery typically elicits images of the pearl-clasping super-rich with jaws dropped at fake Picassos, but the crime is also often linked to money laundering, tax evasion, and drug trafficking. It is the third highest-grossing criminal trade in the world over the last 40 years, according to the US Department of Justice and UNESCO, just behind drugs and weapons. Thomas Hoving, the former director of the Metropolitan Museum of Art, once estimated that 40 percent of the artwork in circulation was fake.

Driving criminal interest is the amount of cash that has been injected in the art world in the years since Myatt's forgery heyday. In some respects, it mirrors the giant pools of money sloshing around in Manhattan or London real estatefunds that are relatively concentrated in a few hands spending it in a few places. Critics contend there's low incentive to catch criminals and that, in some cases, alleged victims may benefit from being in on the con. (Others are so desperate to be in the art market, they're taking on massive debt to do so.)

The global art market in 2018 totaled some $67.4 billion, according to a joint report from Art Basel and UBS, an increase from $39.5 billion in recession-era 2009. And as the super wealthy look for more places to park money while diversifying their holdings, wealth managers and art dealers have welcomed new dollars, with some going so far to pitch (fee-heavy) hedge fund-like investment vehicles that pool money to acquire art.

That's reaped fortunes for some, but not necessarily motivation to catch art criminals. Generally, artbe it real or fakeis being used to move money more than ever, former forgers, law enforcement agents, and experts suggest. And ironically, the forgers are among the most vocal.

"It was a mistake I made and it was time to come to do good things," Myatt said. "To just face up to it."

"Im trying to do something good out of something bad."

As Russian billionaire and avid art collector Dmitry Rybolovlev faced divorce from his wife, Elena, in 2008, the works that once proudly graced the walls of auction houses and made their way into his own collection were now a financial liability. So Rybolovlev set up an elaborate scheme to park his lofty art collection in an offshore entity, according to the Panama Papers.

Stowing away the works was no easy feat, as during his 23-year marriage, Rybolovlev, whom Forbes ranked as the 224th richest person in the world, had amassed a world-class collection that included works by Picasso, van Gogh, Monet, da Vinci, and Modigliani, among others. But as the marriage buckled, Rybolovlev moved the art to a shell company reportedly set up by the notorious and since-shuttered firm Mossack Fonseca in the British Virgin Islands. That took it out of Switzerland, part of an attempt to shield it from his wife's name or the divorce court there. (Rybolovlev is involved in further litigation with his art dealer.)

While there's no evidence Rybolovlev was dealing in forged works, it's just one of many recent scandals involving the secretive strategies of the art world, and its role in moving money at a time when oligarchs across the world have come under harsh scrutiny. This past May, longtime titan dealer Mary Boone, who was convicted for tax evasion at her gallery, reported for a 30-month prison sentencea rarity in an industry that often sees large amounts of money shifting hands. Art has a recurring role in the use of offshore shell companies, the Panama Papers showed, including allegations that the true buyers and sellers of major works may often be concealed.

The scene in John Myatt's studio | Photo by Wendy Huynh

The same goes for the ongoing saga of Jeffrey Epstein. As speculation mounted about Epstein's actual net worth in the days leading up to his death, so, too, did questions around his art assets and how they may have fit into his alleged crimes. Among his art collection were "Parsing Bill," a painting of Bill Clinton in a blue dress; a portrait of himself in a photorealistic prison scene; and a painting of a nude woman. It's unclear what their market worth is, but Epstein was "amused to have in his house fake art which looked like real art," longtime friend and art dealer Stuart Pivar told Mother Jones.

One reason fakes proliferate is simple: It's relatively easy to forge a painting. And if it's perceived as accurate, it can be hawked as an asset andin some casesget bought and sold with few or no questions asked.

Especially if the art is moving between hands that are trusted. Of the art authenticity frauds investigated by the FBI in the last three decades, an estimated 87 percent were perpetrated by art world "insiders," a sort of Ponzi scheme via canvas. Among the most notable was the downfall of the Knoedler Gallery, a storied enterprise that closed its doors after 165 years in 2011 amid allegations that it had sold fake works of Mark Rothko, Jackson Pollock, Robert Motherwell, and others, often with little due diligence.

"It's truly shocking," said Peter R. Stern, an art attorney, of the Knoedler scandal. In his line of work, Stern represents galleries, artists and collectors in an array of matters including handling major transactions, aid with estate planning, and conflicts over art authenticity or ownership. "The behavior was awful, but I also think that buyers did little or no homework."

Photo by Wendy Huynh

Among the obvious tasks, Stern said, is tracing a work's provenance, the paper trail that shows how it has changed hands since creation. Today, the internet has made it easier than ever to find out more about a work's origins, but it has also made it easier for skilled forgers to create fake art or documents to match them.

"The internet has opened up whole new marketplaces," Tim Carpenter, FBI supervisory special agent who program manages the Bureau's Art Crime Team, said in an interview. "Day in and day out, it's not just people buying huge pieces of art. The money is at the mid-level stuff, passing off those fake pieces as real. Back before online marketplaces and social media took over, you had galleries and middlemen doing due diligence. Now, there's no middleman. You have freer access to bad art."

After decades of art crime cases being handled on an ad-hoc basis, Carpenter's group was formalized within the FBI in 2004. In addition to casework, the unit also conducts trainings to aid in handling art and cultural artifacts. Carpenter said the FBI does not publicly release data on the number of cases it pursues, but noted "we stay very busy."

High-end art can be hard to move, but criminals looking to monetize quickly may go for lower-profile deals that draw less attention. As prices increase for top-tier art, values across the board pull up, as well. "We have a lot of concerns about the explosion of value in the art market these last 10 years," Carpenter said. "Theres a lot of risk and threat there for us."

On a July afternoon in Jersey City, convicted art forger Alfredo Martinez could be found recounting his claims that he got away with faking the works of Jean-Michel Basquiat for nearly 20 years.

Sitting at his desk in a black T-shirt and matching sweatpants, his long, curly dark hair askance, Martinez, 52, looked at a large flatscreen, clicking through images of his "Basquiats." He discussed his oil stick technique and said he used tea to create an aging effect on paper. Power tools, paint brushes, and papers lay scattered about him in his high-ceiling studio at MANA Contemporary, a lofty workspace for artists.

Alfredo Martinez in his New Jersey lair | Photo by Tuhsayoh

In recent months, recovery from the amputation of five toes on his right foot after an art-related accident had kept Martinez closer to his computer screen than his easel, he said. But it had not dampened his enthusiasm for curating shows for younger artists ("I like the kids"), discussing his time in prison ("looked like Oz, but it felt like Seinfeld"), or sharing anecdotes of being a self-described "street punk" in New York's art scene during Basquiat's heyday ("I would have known him better if I was a big-chested blonde").

The FBI got a tip when Martinez tried to sell $185,000 worth of "Basquiat" art, complete with forged certificates of authenticity, to two dealers in Manhattan. If they had been real, they might be worth millions today. It landed him a 21-month stint in federal prison and a peculiar flavor of infamy in the art world upon his release in 2006. (Martinez said that he was drawn into forgery because of "money. And I was lazy.")

Martinez, for one, talks of auction houses today as "Kabuki theater" and takes a "sarcastic approach" to the art establishment, even as he continues to participate in it. Then, and now, art dealers are eager to take cash from the wealthy, many of whom may not be performing ample due diligence, he said.

"Duh," Martinez said, adding, "Youre literally printing money."

Photo by Tuhsayoh

So lax is the current state of affairs that 73 percent of wealth managers, 74 percent of art professionals and 64 percent of collectors said that the art market "needed to modernize its business practices to meet the expected standards of a transparent, trustworthy and developed marketplace," according to a 2017 Deloitte and Art Basel report. It also found that 83 percent of wealth managers "see authenticity, provenance, and attribution issues as the greatest risks in the art market" and 65 percent "felt that money laundering is a serious threat to the credibility of the art market."

This year, the House Financial Services Committee introduced money-laundering prevention legislation that proposed including "dealers in art and antiquities" among the institutions that would be monitored. In recent years, the European Union has also moved on similar regulations. Among the regulatory kerfuffles are freeports, or warehouses where art may be stashed for years. They have long existed in locales like Switzerland and enjoyed generous tax benefits, as they're technically storing art that's deemed to be in transit.

"Certain market prices are getting out of hand," said David Drake, founder and chairman of LDJ Capital, a multi-family office that includes an art advisory as part of its offerings. Drake's firm does not conduct provenance research for clients, but rather handles insurance and financing after the fact.

The upper crust of the art world appears to be trying to distance itself from the industrys criminal underbelly while also seeking to bolster buyer confidence. Many artist catalogues, including those of Basquiat and Andy Warhol, have refused to admit any new works, concerned that they could be adding their coveted stamp of approval to a work that is inauthentic (while also enjoying control of the supply and demand of the market). Auction houses have tried to fight back by bolstering their forensic efforts, notably Sotheby's with its acquisition of art forensics firm Orion in 2016. A spokesperson for Sotheby's did not respond to requests for comment.

Only a fraction of art that is sold, however, will undergo such robust due diligence. And many works that are being forged are relatively modern, rendering tasks like dating paints and canvas aging effectively moot.

Some forgers, often as part of plea deal negotiations, may turn into informants. Now retired after two decades at the Bureau, Robert Wittman, the FBI agent who investigated Martinez's case in an undercover operation, runs a private art recovery and consultancy firm based in Philadelphia. He estimated that 75 percent of the illegal art marketthat is, art that is involved in money laundering or otherwise connected to crimeis fake.

Still, people keep buying.

"Fraud has followed the art world because of the rise in value," Wittman said. "Bank robbers go there because thats where the money is. Thats the exact same situation in the art market. The growing art values since 1970, they've been through the ceiling. And with paintings selling for $200 million, criminals follow that and decide to get involved."

Ironically, some in the art world mused that Martinez's arrest brought even more attention to Basquiat's work, as his ability to forge and sell the paintings underscored the demand for the artist, who died at the age of 27 in 1988. (In 2017, "Untitled," a 1982 work by Basquiat, fetched $110.5 million, at the time making it the highest sum paid at auction for an American-produced work of art.)

That's all the more reason that Martinez is cynical about the financial froth in the art world today. He noted that in the end, it wasn't the quality of his fake artworks that landed him in prison, but a disagreement with a gallery owner he said hadn't paid him. That owner, Martinez added, tipped off law enforcement. (The FBI agent who busted Martinez has a different recollection of what led to the tip-off. According to Wittman, the buyer had spotted mistakes in the forged certificates. "Usually people who do fake certificates dont mess them up like that," Wittman said.)

Today, Wittman and Martinez are still in touch, this time as friends.

Alfredo Martinez has a complicated relationship with the works of Basquiat. Left photo courtesy of Alfredo. Right photo: Jean-Michel Basquiats Undiscovered Genius Jean-Michel Basquiat 1983

"When you work undercover, you have to create a relationship with someone, and trust. It's befriending not betraying," Wittman said. "Alfredo calls and I'm happy for him. He got down the wrong path and now it seems like he's doing well."

These days, Martinez sells his own workoriginal creations and labeled replicas of Basquaitslargely through his website and Instagram, mostly foregoing the use of agents and galleries. He said he's starting to see things differently as his own original work gains attention, including one painting of a gun that is now part of MOMA's permanent collection.

Moving carefully on his injured foot, he walked across his studio to a table where a series of drawings were laid out: figures of people, scorpions. He said they were reproductions of what he had done and had lost, either taken by prison authorities or simply because they ended up in the hands of dealers beyond.

"I guess Im forging myself," he said.

Follow Mary Pilon on Twitter.

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Whats the Future of Doctor Manhattan on Watchmen? – The Ringer

Posted: at 6:42 am

Ahead of the debut of HBOs Watchmen, it wasnt clear what a story set after the events of the iconic 1980s comic book series would look like on TV in 2019. Showrunner Damon Lindelof adamantly referred to the show as a remix rather than a direct adaptation or sequel. When Episode 1 opened with a horrific retelling of the real-life Tulsa Massacre of 1921 and closed with a shot of a black man sitting at the feet of a lynched white police chief, the elusive nature of the showone that on the surface appears to be about superheroesonly intensified.

The subsequent eight episodes were a blend of impeccable writing, acting, and directing that lived up to the tall order of sharing the name of whats considered to be one of the all-time great graphic novels. The season finale, See How They Fly, left a few loose ends (the mysterious Lube Man is still out there sliding through the streets of Tulsa) and rushed a bit to tie everything together (providing more concrete answers than Lindelof typically does), but it otherwise rounded out one of the most thrilling television series of the year.

To wrap up Watchmens first (and potentially only) season, were going to break down the two plans to steal Doctor Manhattans powersone designed by Lady Trieu and the other by the Seventh Kavalryand how they panned out before revisiting the graphic novel one last time.

The finale begins by revealing Lady Trieus parentage with a flashback to the day before 11/2 in 1985 at Adrian Veidts Karnak facility in Antarctica. While the Worlds Smartest Man relishes in the genius of his master plan while recording his address to future president Robert Redford, the original BianLady Trieus mother and the elder version of the clone weve seen for the greater part of the seasonsneaks into Adrians office. Shes a member of Adrians cleaning staff, one of the many Vietnamese refugees whom Veidt has employed. Bian enters Adrians password into his computer to open a refrigerated vault hidden away behind a massive painting of Alexander the Great that contains a catalogued collection of his sperm samples (Adrian later declares that hes never given himself to a woman, but I guess that didnt stop him from finding a twisted way to pass on his legacy). Bian takes a vial to impregnate herself, revealing in the process that Adrian is Trieus father.

Thirty-three years later, in 2008, the Worlds Smartest Woman arrives at Karnak to introduce herself to her father. Without revealing their relationship, Lady Trieu earns herself a trip inside the facility by mentioning the little-known truth behind 11/2 and feeding Veidts ego by praising his unappreciated brilliance. Trieu briefly acts impressed by Adrians squidfall technology before calling it nothing more than a rerun and sharing a world-saving plan of her own: to destroy Doctor Manhattan and absorb his abilities. If I can take his power, I can fix the world, she tells Adrian. Disappear the nukes, end starvation, clean the air. All the things he shouldve done.

Even as Adrian patronizingly jeers and questions her, Trieu backs up her bold claims by explaining her process, from how she tracked down the blue gods location on Europa by sending out space probes that scanned the galaxy for his unique radioactive frequency, to her designs for a quantum centrifuge that could harness Doctor Manhattans abilities and transfer them to her. All she asks of Adrian is a cool $42 billion; in this moment she finally reveals to Adrian that she is his daughter. Outraged by the news of Bians thievery, Trieus existence, and her nerve to ask for money, Adrian adamantly denies her request.

When my parents died, I inherited wealth beyond imagining, and I gave it away, because I wanted to demonstrate that I could achieve anything starting from nothing, Adrian says to Trieu. And that is what I offer you, Sample 2346: nothing. And I will never call you daughter.

Back on Europa, we return to our favorite interplanetary castaway, now eight years into his life in paradise. And at long last, help has finally arrived. A spacecraft lands on the castle grounds, and Adrian exits his cell through an underground tunnel hes dug. He kills the Game Warden, who was trying to prevent his master from deserting their moon one last time, before walking past all his servants to enter his shuttle back to Earth. As he steps into the spacecraft and the ship enters space, the sign Adrian carved out of his servants bodies in Episode 5 is revealed in full: SAVE ME DAUGHTER. In full Star Wars fashion, Adrian is essentially frozen in carbonite for the duration of his space flight, solidified as the gold statue thats been standing in Trieus vivarium all along.

Back in present-day Tulsa, the Millennium Clock is about to be activated. Lady Trieu has completed her lifes work, and just as she told Angela, she has found a way to bring back both of her parents to witness the momentous occasion. With Bians clone and an awakened Adrian Veidt at her side, Lady Trieu starts up the clockthe flying quantum centrifuge Trieu built without the help of her estranged fatherand heads to downtown Tulsa to set up for the final piece of her plan.

Meanwhile, the Seventh Kavalry is also preparing to steal Doctor Manhattans powers, though theyre completely unaware that theyre playing right into Lady Trieus plans. Senator Joseph Keene Jr. has gathered the senior leadership of their white supremacist organization, including his father and Jane Crawford. Agent Laurie Blake is there as well, still held captive as they all await her ex-boyfriends grand entrance, and Wade Tillmanwho had been missing ever since a group of Kavalry members failed to kill him in his homehas managed to sneak into the warehouse wearing one of the Kavalrys trademark Rorschach masks. Doctor Manhattan is teleported into a synthetic lithium cage theyve constructed using old watch batteries (a painstaking task that we witnessed a glimpse of all the way back in the series premiere), catching us up to the moment he disappeared outside of the Abars home at the end of the previous episode. The cage functions similarly to the tachyon particles that limit Doctor Manhattans abilities, confusing his sense of time; inside the cage, he starts repeating lines of dialogue he said decades earlier, in the pages of the graphic novel. With the dazed blue god imprisoned, Keene addresses his audience, outlining the Kavalrys plan.

Thirty-four years ago, Adrian Veidt unleashed his monster on the world. No, not his giant one-eyed octopus, but his puppet president, Keene says as he begins to strip off his clothing in anticipation of his transformation into the new Doctor Manhattan. First, he took our guns. And then he made us say sorry. Sorry for the color of our skin. All we wanted was to get cops in masks, take some power back, start ourselves a little culture war. Keene concedes that their original planto get him into the White Housewas a little half-baked. But then the White Night happened, and changed everything.

When the Kavalry carried out their coordinated attack on the Tulsa police force, all went as planned, except for the raid of the home of Angela and Cal Abar. Cal, accessing his subdued abilities in an act of self-preservation, zapped one of the two Kavalry hitmen to Gila Flats, the site where Jon Osterman died and was reborn as Doctor Manhattan. The Kavalry was able to piece together Cals true identity, and from that point on their mission to make Keene president was punted for the bolder goal of making him into a god.

Just before Keene enters the chamberfrom which he will supposedly reemerge from as the blue prophet who will restore (restore) white power in America, Angela warns the Kavalry that theyre about to fall right into Lady Trieus hands. They proceed anyway, initiating the transference of Doctor Manhattans power. Right on cue, the Kavalry finds themselves suddenly in downtown Tulsa, now serving as an audience to Lady Trieu.

As the two plans converge, the Kavalry proves to be no more than a cog in Lady Trieus elaborate scheme (it turns out both of the Kavalrys plans were a little half-baked). Trieu begins to address the dazed group of white supremacists before opening a chamber that releases the pool of human slush that used to be Senator Keene; hed been reduced during his failed attempt to transfer Doctor Manhattans atomic energy (crucially, Keenes blood seeps underneath the bars of blue Cals cage). Trieu resumes her speech, reading the message that Will Reeves has asked her to deliver to the group hes been hunting down since his days as Hooded Justice in the 1930s: You represent the senior leadership of Cyclops, an organization that has terrorized and victimized men, women, and children of color for a century, including this very place, the site of the Greenwood Massacre of 1921.

Before Trieu finishes reading, Jane Crawford cuts her off to tell her to just kill her and the Kavalry already, and Trieu complies. She retrieves a remote from one of her crewmembers and flicks a switch, obliterating them all with a flash of purple light.

Following the casual massacre, Doctor Manhattantouching the pool of Keenes bloodteleports Adrian, Wade, and Laurie to Karnak, leaving Angela behind as his death approaches. Enraged that Doctor Manhattan shipped off her father before she could properly gloat about her success, Trieu fires up the centrifuge to extract his energy.

In Karnak, Adrian seizes the opportunity to save the world yet again, as he reminds his new companions of his murderous heroism. (Wade, who has lived nearly his entire life traumatized by the events of 11/2, is not too happy about this.) Adrian quickly devises a plan to rain one final squidfall over Tulsa, only this time he wants to significantly lower the temperature to unleash a hailstorm of frozen cephalopods.

Trieu succeeds in destroying Doctor Manhattan, but just then, the frozen squidfall begins, cartoonishly busting a hole through Trieus hand before sending the centrifuge crashing down upon her.

As the frozen squids fall, Bian takes shelter in the Manhattan prayer booth; the Tulsa policewho had arrived just as the squidfall beganscramble for cover; and Angela runs to the Dreamland Theatre to find her children and Will Reeves. Here, in the same theater that young Will watched Trust in the Law moments before the Greenwood Massacre of 1921, Will tells his granddaughter about how he and Jon Osterman made a deal to help each other, as well as what it means to put on the mask. The hood, when I put it onyou felt what I felt? Will asks her, referring to the Nostalgia pills she took that allowed her to experience the moment he became Hooded Justice.

Anger, Angela replies.

Yeah, thats what I thought too, Will says. But it wasntit was fear, hurt. You cant heal under a mask, Angela. Wounds need air. Will tells Angela that it was Jons idea to make a deal with Trieu all along, and that Jon knew he was going to die but said, You cant make an omelette without breaking a couple eggs, a phrase that would supposedly make sense to Angela when the time was right.

Will and Angela wake up the kids and return to Angelas house, passing by all the destruction left in the wake of Trieus failed plans. Just before the credits begin to roll, Angela cleans up the broken eggs scattered across her kitchen floor from her fight with the waffle-making Doctor Manhattan. She finds one egg remaining in the carton, still intact, and remembers the time that Jon told her that he could theoretically pass his abilities to another person through the consumption of organic material thats been exposed to him. Angela walks out to the pool, swallows the raw egg, rolls up her pants, and sets her foot over the water to test out the theory just as the season comes to an end.

Despite an incredible final performance by actress Hong Chau, Lady Trieu went out with little more than a whimper, capable of mustering no more of a reaction to her fathers attack than the utterance of motherfucker in Vietnamese with her final breaths. Wills mesmerism device that he stole from the Cyclops group decades earlier was never used again after seeing its power in manipulating Crawford into hanging himself, and the Kavalrys fate was decided in one quick purple flash. For all the meticulous effort the show put into weaving an intricate web of mystery, the vast and insidious conspiracy ultimately proved to be more hollow as the show rushed toward the finish line. The conclusions saving grace, however, was found in the chaoss calm aftermath in the Dreamland Theatre.

As Victor Luckerson recently wrote in The New Yorker: What Watchmen nails, more than details of Greenwoods history, is the way that history itself is so susceptible to manipulation, distortion, and erasure. A brutal invasion became a victimless crime, then a repressed memory, then a hazy urban legend that few people had even heard about. While bending elements of real historical events like the Greenwood Massacre and the Vietnam War, as well as Alan Moore and Dave Gibbonss original story, HBOs Watchmen remix turned out to be a story about a black family reshaping history. Will Reeves revealed that the first superhero was black, as he fought to eliminate white supremacy in the 1930s as Hooded Justice, and his granddaughter unknowingly carried the mission forward decades later as Sister Night. The two share similar traumatic experiences a century apart, while literally sharing some together through the aid of the psychoactive drug, Nostalgia.

As Will and Angela sit together in the Dreamland Theatre, just as Will did with his mother on the day of the Greenwood Massacre, we see how similar their paths have been, how they both masked their pain caused by racism and senseless violence at the hands of terrorists. And together, after delivering justice to white supremacist descendents of the massacre, the two are finally on the path to healing.

Throughout this entire season of Watchmen, each episode was laden with Easter eggs and callbacks to the original source material. You could compile an exhaustive list for each episode, but for the finale, Ill just point out the three that I appreciated the most.

Adrians Bullet Catch

When watching the Game Warden confront Adrian before his master left for Europa, you mightve thought, Did this guy really just catch a damn bullet with his bare hands?! And yesyes, he did but it also wasnt his first time. Heres Laurie trying kill Adrian on 11/2, only to find out that hes got quicker hands than Michael Thomas:

The Original Archie Ship

After Adrian saves the world from his daughters attempt to become an all-powerful god, he leads Laurie and Wade to the vessel that would bring them back to civilization. The ship is called Archie, as Laurie recalls fondly, and its the original ship that her ex-boyfriend Dan Dreiberg designed and used back in his days masquerading as the second Nite Owl. In the comics, Dan and Rorschach flew to Karnak in Archie on 11/2 to try to stop Adrians attack of New York. The ship has been collecting dust ever since, and now Laurie and Wade will use it to bring Adrian in to finally answer for his crimes.

Rorschachs Omelette Line

Doctor Manhattans hugely important omelette idiom was actually used in the graphic novel as well, only then it was said by Rorschach. After Rorschach interrogates the retired supervillain, Moloch, he swallows a raw egg and says the line on his way out the door:

Though the ending aligned with Lindelofs sensibilities, the ambiguous closing moments also mirrored the final page of Moore and Gibbonss graphic novel. The original Watchmen story ends at the office of the New Frontiersman, just as an editorial assistant, Seymour, discovers Rorschachs journal that contains the truth about 11/2. Rorschach had sent it to the newspapers office just before leaving for Karnak, where hed eventually be killed by Doctor Manhattan. And as the story comes to a close, the reader is left wondering what will happen if the journal is published, and whether or not the truth will undo the supposed utopia that 3 million New Yorkers died for.

HBOs Watchmen supplied answers to these very questions. Rorschachs journal was published, but the greater public didnt believe the words of a violent sociopath, especially while there were squids still periodically raining down from the sky. Only a select few actually knew that the journal was full of the truth, and others unconcerned with the truthlike the Seventh Kavalryused it to fuel their mistrust in the government.

As Angela reaches her foot over the pool in the final frames of the season, viewers are left with the same uncertainty that the journal elicited. Was Doctor Manhattan right about his theory? Has Angela attained all of his powers? If so, what will she do as the new Doctor Manhattan?

The fact that Doctor Manhattan told Angela that it was important for her to see him walk back and forth on the pool in the previous episode suggest he was right, but for now, theres no telling what happened the moment her foot hit the water. If Watchmen moves forward with a second season, we may find that not only does the American Superman exist again, but that she is black and living in Tulsa, Oklahoma.

Disclosure: HBO is an initial investor in The Ringer.

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Scientists Sequenced The Genome Of The Carolina Parakeet, Americas Extinct Native Parrot – Forbes

Posted: at 6:41 am

This Carolina parakeet was collected sometime in the late 1800s.

Not very long ago, wild parrots lived in the forests of New York. The brightly-colored birds squawked among the treetops of old-growth riverine forests and swamps from Florida to New York and as far east as Colorado, gathering in flocks of hundreds at a time. Today, the great vociferous flocks are gone, and the bright green, red, and yellow plumage can be seen only in museums.

The last known Carolina parakeet was born sometime around 1883 and died in the Cincinnati Zoo in 1918, in the same ill-fated cage where the worlds last passenger pigeon had died in 1914. Inca, the last Carolina parakeet, had outlived his mate, Lady Jane, by around a year and as far as anyone knew, the pair had outlived their wild relatives by nearly a decade. No one had reported a credible sighting of a wild Carolina parakeet since 1910.

The Carolina parakeet has been extinct for roughly a century, and a new genetic study pins the blame squarely on humans.

The Last Stand Of Americas Parrots

As European settlers and their descendants pushed westward in the 1700s and 1800s, they cleared many of the forests the Carolina parakeet had once called home. They also shot the birds in droves to keep them away from grain fields and to collect their bright feathers for ladies hats. The Carolina parakeet made an easy target; flocking instinct would bring large numbers of birds back to the scene of a fresh kill, giving hunters another shot at them.

By the mid-1800s, Carolina parakeets were rare outside the swamps of Florida, and by 1900, they couldnt be found anywhere else. But even in their last bastion of habitat, Carolina parakeets seemed to be doing pretty well, under the circumstances. Farmers had stopped hunting them, because they turned out to be useful for keeping cockleburs in check (the Carolina parakeet was one of the only animals who could survive eating the poisonous plant, although the toxic glucoside accumulated in the birds flesh and made them deadly prey. Cats who ate Carolina parakeets usually died soon after). And naturalists described large flocks, with plenty of young birds and good access to nesting sites.

And then, abruptly, the Carolina parakeet simply vanished. A century later, ecologists still dont understand what happened. Maybe, some say, the species wasnt faring as well as it looked from the outside; population decline and habitat loss could have left them with a limited gene pool, doomed to fade away before too long. But maybe, others argue, the Carolina parakeet would have been just fine if they hadnt been exposed, in their last refuge, to deadly poultry diseases like Newcastle Disease from nearby farms.

If this is true, the very fact that the Carolina parakeet was finally tolerated to roam in the vicinity of human settlements proved its undoing, wrote the Audobon Society a few years ago. Theres no actual evidence to support the poultry disease hypothesis: no eyewitness report of sick parrots with symptoms of something like Newcastle Disease, and no smoking gun in the form of pathogen samples from a preserved parrot corpse. But a new study, published in the journal Current Biology, sequenced the Carolina parakeet genome for the first time and searched for signs of inbreeding or population decline and found none. That means the species wasnt doomed long before its disappearance, which means something must have tipped the balance.

Solving A Cold Case

Evolutionary biologist Carlez Laluzela-Fox and colleagues sampled nuclear DNA from the tibia (shin bone) and toe pads of a Carolina parakeet, killed and stuffed in the late 1800s and now owned by a private collector in Spain. They used the genome of the extinct species closest living relative, a South American parrot called the sun parakeet, as a reference to help them map the genome and understand what the sequences of adenine, thymine, guanine, and cytosine meant for the birds actual physiology.

Demographic declines leave specific signals in the genomes of the species, explained Laluzela-Fox in a statement to the press. If members of a species have spent several generations breeding with close genetic relatives, or if the overall breeding population was too small, geneticists can spot the signs in an organisms genome.

But the Carolina parakeet genome had none of those warning signs so its sudden extinction wasnt the end of a much longer decline. Something new had happened and the odds are good that it was our fault. That lends some support to the poultry disease idea, although its a long way from actually proving that sick chickens, and not some other problem, actually killed off the Carolina parakeets.

Meanwhile, Laluzela-Fox and colleagues say that the same process they used to look for signs of population decline in the Carolina parakeet genome could also help screen living species for warning signs and maybe solve more extinction cold cases, too.

The genomic study also solved another century-old mystery: how did the Carolina parakeet live on poisonous cockleburs, when their toxins even made the birds flesh too poisonous to eat? In the Carolina parakeets genome, Laluzela-Fox and colleagues found two proteins that interact with the toxic glucoside in cockleburs. They suggest that those proteins allowed the bird to safely enjoy its toxic treats.

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The Extinction of This U.S. Parrot Was Quick and Driven by Humans – Smithsonian.com

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In centuries past, large flocks of noisy, brightly colored parrots squawked their way across the United Statesfrom New England, to Florida, to eastern Colorado. The Carolina parakeet, or Conuropsis carolinensis, was the only parrot native to the eastern part of the country. But by the beginning of the 20th century, it had disappeared.

Experts believe that humans played a prominent role in the species extinction. The clearing of forests to make way for agricultural land destroyed the birds habitat and may have contributed to their loss. They were hunted for their vibrant feathers of green, yellow and red, which made a popular addition to ladies hats. Farmers considered them pests and killed them in large numbers; the parrots were easy targets, due to their unfortunate tendency to congregate around wounded flockmates.

But as Liz Langley reports for National Geographic, some experts have speculated that causes not directly driven by humanslike diseases spread by poultry and natural disasters that fragmented the Carolina parakeets habitatmay have contributed to the species decline. Hoping to shed new light on the issue, a team of researchers sequenced the Carolina parakeets genomeand found that human causes were likely the sole driver of the birds abrupt extinction.

To conduct their analysis, the team looked at the tibia bone and toe pads of a preserved parakeet specimen held in a private collection in Spain. Because its DNA was fragmented, the researchers also sequenced the genome of the Carolina parakeets closest living relative, the sun parakeet, which gave them a more complete picture of the extinct birds genetic profile.

The researchers were specifically looking for signs of a drawn-out decline that might have started before humans began hunting the birds extensivelysigns like inbreeding. They found that after the Last Glacial Period around 110,000 years ago, Carolina parakeets began experiencing a population decline that continued until recent timesbut the still-extant sun parakeets decline was stronger, according to the study.

Crucially, the researchers didnt discover evidence of inbreeding that you might expect to see in a species that has been endangered for some time, which suggests the parakeet suffered a very quick extinction process that left no traces in the genomes of the last specimens, the researchers write in Current Biology. And when extinction happens at a rapid pace, human action is common, study co-author Carles Lalueza tells Ryan F. Mandelbaum of Gizmodo.

Whats more, the study authors did not find a significant presence of bird viruses in the Carolina parakeets DNA, though they acknowledge that further research is needed to rule out poultry disease as a driver of the birds extinction. For now, however, they conclude that the parakeets extinction was an abrupt process and thus likely solely attributable to human causes.

Earlier this month, a separate team of researchers came to the same conclusion about the disappearance of the great auk, a large, flightless bird that appears to have been wiped out by rapacious hunters. These cases offer sobering insight into how quickly humans are capable of decimating a species; the Carolina parakeet, Lalueza tells Mandelbaum, likely went extinct within the order of [a] few decades.

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New tool predicts three-dimensional organization of human chromosomes – University of Wisconsin-Madison

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University of WisconsinMadison researchers have developed a computational tool that can accurately predict the three-dimensional interactions between regions of human chromosomes.

The predictive tool is a boon for researchers studying how cells control the activity of genes. The fine-tuned interaction between regulatory signals and the three-dimensional architecture of chromosomes helps explain how cells achieve their key functions, and how they go haywire, as happens in diseases such as cancer.

The experimental technique to measure these three-dimensional interactions, Hi-C, is expensive, which has limited high-quality data to just a few types of cells. In contrast, the new tool can predict these interactions using much more easily measurable and commonly available data. This could help biologists perform across many cell types more detailed research into tissue development, cancer and other diseases that are affected by this type of distant gene regulation.

Roy

Zhang

UWMadison researcher Sushmita Roy and her graduate studentShilu Zhang led the work, which was published Dec. 6 in Nature Communications. The researchers have made the tool freely available to other scientists and continue to improve the predictive power of the tool, which they named HiC-Reg after the resource-intensive experiments.

We can very cheaply predict the output of Hi-C experiments, which can help us prioritize other regions of the genome to follow up with more fine-tuned experiments, says Roy, a professor in the Wisconsin Institute for Discovery and the UWMadison Department of Biostatistics and Medical Informatics. This can be used as a resource to interpret regulatory variation in the genome.

The human genome consists of 23 pairs of chromosomes. A new study from UWMadisons Sushmita Roy describes a computational tool for researchers to better predict the three-dimensional interactions between chromosomes. Wikimedia Commons

A far cry from the neat, straight lines of DNA pictured in textbooks, real chromosomes fold, twist and bend to fit several linear feet of DNA into a tiny cell nucleus. These loops also bring distant regions of a chromosome together. Some of these regions carry regulatory information that can promote or repress the expression of distant genes. This intricate gene expression magnifies the complexity of traits that organisms exhibit.

Roy and other researchers have previously developed models that could predict whether or not two distant regions of a chromosome would interact. HiC-Reg builds on that model and not only predicts whether two regions will interact but also how strong that interaction might be. It provides a more complex and realistic model of how chromosomal regions interact and potentially regulate gene expression.

The packing of chromosomes into a nucleus allows distant regions of a chromosome to interact and affect one another. Consistently interacting regions are known as topologically associated domains, or TADs. This kind of fine-tuned gene regulation produces more complexity in the traits that organisms express. Navneet Matharu and Nadav Ahituv

To create HiC-Reg, Roys team fed a series of commonly available genomic data, such as the presence of proteins and chemical modifications that activate or repress gene expression, into a machine learning algorithm. It also included Hi-C data from the few cell lines for which it is available. The tool then learned relationships that enabled it to predict the Hi-C measurements for a new pair of genomic regions.

Lets try to use the data thats easy to measure to predict the information thats harder to gather, says Roy. The research was supported by the National Institutes of Health Big Data to Knowledge program, which allowed the team to mine this freely available but underutilized data. Were trying to leverage publicly available datasets as much as possible.

HiC-Reg correctly predicted between 40 percent and 80 percent of regional associations. The tool is more accurate than estimating the strength of interactions based on chromosomal distance alone or just mapping the interactions from a pair of regions in one cell line to the same pair of regions in another cell line. But the interactions were harder to predict in some cell types than in others, a limitation the researchers are now working to overcome.

The computationally intensive work relied on UWMadisons Center for High Throughput Computing, the UW Center for Predictive Computational Phenotyping and the Core Computational Technology research group at the Wisconsin Institute for Discovery.

Other researchers can now use HiC-Reg as-is to predict these three-dimensional interactions in their favorite cell line. Or, they can elect to re-train the program using their own datasets to improve its accuracy for their work.

Roy says that free access is consistent with the question that motivated this research: How can we help biologists gather this data?

This work was supported by the National Institutes of Health (BD2K grant U54 AI117924 and grant R01-HG010045-01).

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Genome Editing Market Exclusive insight on Transformation 2025 – Techi Labs

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Global Genome Editing Market: Overview

Also known as genome editing with engineered nucleases (GEEN), genome editing is a method of altering DNA within a cell in a safe manner. The technique is also used for removing, adding, or modifying DNA in the genome. By thus editing the genome, it is possible to change the primary characteristic features of an organism or a cell.

The global genome editing market can be segmented on the basis of delivery method, technology, application, and geography. By technology, the global genome editing market can be segmented into Flp-In, CRISPR, PiggyBac, and ZFN. Based on delivery method, in vivo and ex vivo can be the two broad segments of the global genome editing market. By application, the global genome editing market can be categorized into medicine, academic research, and biotechnology.

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Global Genome Editing Market: Key Trends

Since genome editing is gaining rising adoption in the domain of scientific research for attaining a better understanding of biological aspects of organisms and how they work, the global genome editing market is likely to promise considerable growth over the forthcoming years. More importantly, genome editing is being used by medical technologies, where it can be used for modifying human blood cells which can then be placed back in the body for treating conditions such as AIDS and leukemia. The technology can also be potentially utilized to combat infections such as MRSA as well as simple genetic disorders including hemophilia and muscular dystrophy.

Global Genome Editing Market: Market Potential

As more easy-to-use and flexible genome technologies are being developed, greater potential of genome editing is being recognized across bioprocessing and treatment modalities. For instance, in May 2017, MilliporeSigma announced that it successfully developed a novel genome editing tool which can make the CRISPR system more productive, specific, and flexible. The researchers thus have a more number of experimental options along with faster results.

All this can lead to a growing rate of drug development, enabling access to more advanced therapies. Proxy-CRISPR, the new technique, makes access to earlier inaccessible aspects of the genome possible. As most of the existing CRISPR systems cannot manage without re-engineering of human cells, the new method is expected to gain more popularity by virtue of the elimination of the need for re-engineering, simplifying the procedures.

Several other market players are focusing on clinical studies with a view to produce effective treatments for different health conditions. For example, another major genome editing firm, Editas Medicine, Inc. announced the results of its pre-clinical study displaying the success of the CEP290 gene present in the retina of primates in the same month. With the positive results of the study, the companys belief in the vast potential of its candidate in the treatment of a genetically inherited retinal degenerative disease, Leber congenital amaurosis type 10, affecting childrens eyesight has been reinforced.

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Global Genome Editing Market: Regional Outlook

By geography, the global genome editing market can be segmented into Latin America, Europe, Asia Pacific, the Middle East and Africa, and North America. North America registered the highest growth in the past, and has been claiming the largest portion of the global genome editing market presently. The extraordinary growth of this region can be attributed to greater adoption of cutting edge technologies across several research organizations. The U.S., being the hub of research activities, is expected to emerge as the leading contributor. Asia Pacific is also likely to witness tremendous demand for genome editing over the forthcoming period, assisting the expansion of the global genome editing market.

Global Genome Editing Market: Competitive Analysis

CRISPR THERAPEUTICS, Caribou Biosciences, Inc., Sigma Aldrich Corporation, Sangamo, Intellia Therapeutics, Inc., Editas Medicine, Thermo Fisher Scientific, Inc., and Recombinetics, Inc are some of the key firms operating in the global genome editing market.

The study presents reliable qualitative and quantitative insights into:

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Taking CRISPR Safety to the Next… – Labiotech.eu

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Gene therapies are experiencing a new era. CRISPR is current. CRISPR is trendy. CRISPR is on many researchers minds. But its sudden success has also triggered concerns about its safety. Can the proteome help solve these issues?

Although the landscape of genome editing has been evolving for nearly 50 years, it has only recently seen dramatic changes. After experiencing years of stagnation resulting from severe setbacks in clinical trials and a lack of efficiency, zinc-finger nucleases appeared on stage. This time, researchers were hampered by yet another problem: the patent landscape and design complexity. Licensed and commercialized for research by Sigma-Aldrich, the technology was costly which made it difficult to access as a general tool for researchers.

At the time, zinc-finger nucleases were a fantastic adventure, says Jens-Ole Bock, CEO of COBO Technologies. It was exciting to know that we had a tool that could do specific changes to the genome. But zinc-finger nucleases were expensive, very complex, and difficult to access. There were some alternatives on the market for a few years, and then CRISPR-Cas9 appeared. Suddenly we had this really great genome editing tool that was cheap, with a simple mode of action, and available for everyone to work with.

As a result of this democratization, research in the field of genome editing sped up dramatically and the CRISPR technology continues to evolve very fast. However, in 2018, a small number of publications raised concerns about the safety of CRISPR, revealing that the technology might cause severe side effects due to off-target mutations.

With CRISPR we now have a very effective and easy system that everyone is using, Bock says. There are more than 5000 publications a year in CRISPR research and we are now moving towards its clinical application. This also means that we need to focus on CRISPR safety concerns. If we want to move to the clinic, we need to understand exactly what is going on inside the cells when we apply CRISPR. What is the target? What happens in the target area? Are there off-target events? Is there immunogenicity? How is the biology of the cells affected?

In order to better anticipate the risks of genome editing tools, Bock and his colleagues founded COBO Technologies, a company that focuses exclusively on quality control of genome editing. The team has developed a platform called PIPPR that can address concerns about CRISPR safety on a proteome level, together with SCIEXs mass spectrometry SWATHAcquisition technology. The PIPPR platform offers a proteomic expression analysis solution for cells that have been genetically modified. Using SWATH Acquisition researchers can then visualize their results and identify and quantify between 3000-5000 proteins in any cell line, whether of plant or animal origin.

There is a growing need to understand how the proteome changes during different CRISPR applications, explains Bock. We need a powerful method that is robust, fast and sensitive, to both confirm expected changes and to check for unexpected changes in proteins and different pathways. PIPPR, powered by SWATHAcquisition, is the first platform to really address this and will make it possible for researchers to see and compare expression levels of more than 3000 proteins in their cell line projects. Using this detailed, large-scale proteome information, the efficacy and safety of genetic modifications can now be assessed.

COBO Technologies customers work with genome editing tools and often want to understand how the cells biological makeup is modified when they have applied CRISPR. By looking at the expression of proteins in the edited cell line and comparing these to the wildtype cell line, the team can identify changes that may have occurred during genome editing.

The team at COBO Technologies has developed a full package service that enables customers to use validated reagents to extract proteins from their modified cells. Once extracted, the proteins are sent to COBO Technologies where they undergo a robust analysis using SWATHAcquisition. Within four weeks, the customers will receive a full bioinformatic analysis of the cells proteins.

Some of the companys customers use the PIPPRplatform and SWATHAcquisition technology to compare the proteome of their modified cell line with that of the wild type cell line. This allows them to see what impact the genetic modification had at a proteome level.

Other customers are more interested in seeing the effect of different genome editing tools on their cell line and comparing these with each other. They want to know whether there is a difference between the two, whether we get different proteomic profiles. Has anything changed? Is there toxicity in one, but not the other? Might we have immunogenicity issues with some CRISPR tools, but not with others? All of this information can be gained by looking at the proteome level, which is especially important when working with CRISPR safety, says Bock.

Since before the initial release in 2010, SWATHAcquisition has been continually developed in collaboration with customers, says Ferran Snchez, Marketing Development Manager at SCIEX. SWATH Acquisition ultimately immortalizes a sample by creating a digital data record of all observable species. As a data-independent acquisition strategy, SWATH Acquisition collects mass spectrometry (MS) and MS/MS information on every detectable peak leaving you with an option to re-interrogate your sample data should new questions arise tomorrow. The extra dimension of data interpretation achieved provides increased confidence in identification for both quantitative and qualitative discovery workflows.

Moreover, the combination of the two technologies allows researchers to save time. We are working in a research environment where time is a big thing, says Bock. Researchers are doing a lot of things and we need technology that is fast, robust, and efficient because CRISPR safety is becoming increasingly important as we move into clinical phases.

With SWATH Acquisition, a single generic MS acquisition method is used all of the time, explains Snchez. This means you select your compounds of interest from the digital map after you collect your comprehensive MS and MS/MS data on your sample. Should your data analysis present new questions, you can simply re-interrogate the data youve already collected rather than updating your acquisition method and re-analyzing your sample from step one. Once your SWATH Acquisition method is optimized for a sample type, the same method can be used for analysis across many similar samples no matter what analytes youre studying, saving tremendous time.

As basic genome editing moves closer from bench to bedside, more and more studies have to be done into the safety of CRISPR and other genome editing methods. Currently, interventions are used for diseases for which the genetic background is very clear and patient stratification is possible.

Furthermore, while most drugs today follow clear regulations, there has yet to be a standard laid down for CRISPR. This is especially important for CRISPR safety as the technology moves from research to clinical phases.

We are at an extremely early stage, says Bock. At the moment, we are merely looking at what standards to define at the DNA level. But once we have defined these, we need to describe standards for the RNA level, and later the proteome level. We are at a very early stage regarding the safety and efficacy of CRISPR.

Do you want to be at the forefront of CRISPR safety research? Get in touch with SCIEX at [emailprotected] and learn how you can use SWATHAcquisition to advance your studies. To request more information on the PIPPR platform, contact COBO Technologies at j[emailprotected]

Images via Shutterstock.com, SCIEX, and COBO Technologies

Author: Larissa Warneck, Science Journalist at Labiotech.eu

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Taking CRISPR Safety to the Next... - Labiotech.eu

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