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Daily Archives: September 27, 2019
Carnival Inks Deal to Build Pier on Half Moon Cay – Cruise Fever
Posted: September 27, 2019 at 7:47 am
Carnival Corporation, the worlds largest cruise company with nine cruise lines and over 100 cruise ships, has signed an agreement with the Bahamas to build a pier on their private island, Half Moon Cay.
Half Moon Cay is visited by ships from Holland America Line and Carnival Cruise Line. Cruise ships currently need to anchor offshore and use tender boats to ferry passengers to the island. Because of this, calls can be canceled due to rough water which makes tendering unsafe.
A pier for cruise ships to dock at will dramatically cut down on missed calls to the private island.
Carnival is planning an $80 million investment to Half Moon Cay. The project is expected to begin in 2020 and will be built to withstand a Category 5 hurricane.
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The pier will also allow larger cruise ships to visit Half Moon Cay. This includes Carnival Corporations 180,000 gross ton LNG powered vessels, the largest ships built by Carnival.
Half Moon Cay, one of the most popular cruise line private islands, is on the island of Little San Salvador. The island is well known as one of the regions most beloved ports, visited by guests sailing with Holland America Line and Carnival Cruise Line.
The current development on the western side covers less than 3% of the 2,400-acre island and includes a tender marina. The new addition will be on the northern part of the island and include a pier able to accommodate larger ships. The beautiful beaches of Half Moon Cay will continue to be a main attraction.
Half Moon Cay received little impact from Hurricane Dorian and cruise ships have resumed visits on the island.
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Staten Island’s Epic Wait for Alternative to Private Bus Service Just Got Longer – THE CITY
Posted: at 7:47 am
A Staten Island-bound express bus picks up passengers on 34th Street, Sept. 24, 2019. Photo: Clifford Michel/THE CITY
A city-subsidized private bus operator unpopular with Staten Island commuters has received a years extension on its contract and an additional $300,000 raising taxpayers tab to $3.8 million.
Board members of the citys Economic Development Corp. approved the extra time for Academy Bus, the Hoboken-based company that supplies service along the SIM23 and SIM24, minutes from an August meeting show.
The contract extension marked the companys third in as many years, amid protracted talk of an MTA takeover for the South Shore routes, which run on weekdays to Midtown Manhattan via New Jersey and the Lincoln Tunnel.
The private-bus service for transit-starved South Shore neighborhoods has been in place since 2001. Academy stepped in five years ago after a previous company went bankrupt.
Riders returning home to Staten Island Monday evening sounded off about late buses and breakdowns.
These are the only bus lines in all of New York City where you have to worry about your bus breaking down in the middle of New Jersey, said Robert Perez of Annadale.
Buses on the SIM23 and SIM24, which serve Annadale and Princes Bay, arent equipped with the MTAs new OMNY contactless fare payment system and accept only MetroCards or cash for their $6.75 fare.
Staten Island has only one MetroCard vending machine location outside the North Shore.
The Academy routes also lack GPS tracking that can tell riders when the next bus will arrive.
There are no updates except for from other riders on Facebook, and you just have to keep checking that, said Lisa Angelo, a 31-year-old Huguenot resident.
Academy and EDC did not respond to requests for comment.
In May, midway through Academys last one-year deal, EDC stepped up to supply Academy with an additional $804,000 to its then-$3.5 million base contract.
A staff briefing to EDC board members attributed the ostensibly one-time subsidy increase to declining fare collections, after the MTA reconfigured Staten Islands bus routes: The redesign resulted in significant loss of revenue for Academy due to lower ridership.
Ridership on Staten Island express bus routes overall has slipped only minimally since the redesign, MTA statistics show. Unlike city buses, the MTA does not disclose ridership numbers for the SIM23 and SIM24.
In an interview, Councilmember Joe Borelli (R-Staten Island) suggested his constituents are stuck with Academy until the MTA takes action.
Its not like theres a large roster of bus companies to even bid on this kind of work, said Borelli.
He maintained the only solution is for the MTA to run the routes Theyve told me many times in the past that theyre going to, said Borelli.
Rumblings of a change have grown louder.
New York City Transit president Andy Byford told the Staten Island Advances editorial board in August that It makes no sense to me to have this third-party doing this operation, and said that many issues that riders have would be solved if the MTA were maintaining the routes.
When asked by THE CITY about the possibility of an MTA takeover, agency spokesperson Amanda Kwan said, Were talking with our city partners.
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Fregate, Seychelles is one of the worlds most beautiful islands to visit here is why – Pulse Nigeria
Posted: at 7:47 am
Islands make for really amazing travel destinations. With the right amount of sand, rustling palms and serene blue water, these wonderful slices of heaven are exactly where you need to go when you need to escape the rat race.
This is why CNN Travel has put together a list of the 10 most beautiful islands across the globe.
It features exotic places like the Milos in Greece, Ecuadors Bartolom, St. Lucia in the Lesser Antilles and Fregate in Seychelles the only African island on the list.
Business Insider Sub Saharan Africa takes a close look at this beautiful island and all the reasons it deserves to be on your travel bucket list.Get ready to be blown away by Fregate (Seychelles), Africas most beautiful island to visit:
Here is why Fregate, Seychelles is one of the worlds most beautiful islands
Seychelle is home to dreamy beaches and hotels but Fregate is the dreamiest of them all.
The National Geographic describes this private island as Part tropical paradise, part wild isle a place where brochure-worthy beaches are inhabited by creatures seemingly plucked from the Galpagos.
ALSO READ: 5 African countries that should be on your 2019 travel list
These creatures include two different species of sea turtles, hundred thousands of lovey tropical Birds, 3,000 free-roaming giant Aldabra tortoises (one of the worlds largest tortoises) and the Seychelles Magpie Robin which was saved from extinction.
Other reasons to visit include:
How do you get there?
Fregate Island has its harbour which means you can visit the island by boat. The island also has a helicopter landing pad and can be accessed via the Fregate Island Airport.
Transport on the island is by foot, golf buggy or bicycle.
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Hong Kong locals fear loss of small-town life with artificial islands – Reuters
Posted: at 7:47 am
HONG KONG (Thomson Reuters Foundation) - Not long after Tom Yam returned to his native Hong Kong after 40 years abroad, he picked Lantau Island to settle in, drawn to its laid-back villages, wooded trails and scenic beaches that seemed a world away from the bustle of the city.
That may be about to change with a plan to build artificial islands off Lantau to ease congestion in Hong Kong, ranked as the worlds least affordable housing market for a ninth year by U.S. research firm Demographia.
The East Lantau Metropolis, to be built on 1,700 hectares (6.6 sq miles) of reclaimed land, will have a central business district and up to 400,000 housing units, with the first of an estimated 1.1 million residents expected to move in by 2032.
They are going to build a city in the middle of the sea at a time when global warming is intensifying, sea levels are rising, and cities are trying to minimize risk, said Yam, who lives in the small town of Mui Wo on Lantau.
If we build another Central Hong Kong, local residents will be priced out, local businesses will be killed, and the new area will be just as congested as the most congested areas in Hong Kong. So where is the quality of life improvement?
Ineffective policy measures, powerful developers and a limited supply of land have led to a huge shortfall of housing in Hong Kong, according to property experts, with an average waiting period of more than five years for public housing.
Hong Kong Chief Executive Carrie Lam, in a speech last year, vowed to ease the shortage by boosting land supply through reclamation and redevelopment, and earmarking 70% of housing on the new Lantau islands for public housing.
Opponents, including planners, conservationists and some Christian groups, say the plan - estimated to cost at least HK$500 billion ($64 billion) - is unnecessary, and will drain Hong Kongs financial reserves and hurt the environment.
The land to be created in this project far exceeds the population and land demand projections, said Brian Wong of advocacy group Liber Research Community.
Alternate land supply options could easily replace this project without the environmental problems, he said.
A spokeswoman from the Civil Engineering and Development Department said that reclamation cost is comparable to the cost of taking over private farming land in Hong Kong.
The government has taken into account the conservation of the natural environment and ecology, and we will conduct the requisite environmental impact assessments, she said.
The former British colony that returned to Chinese rule in 1997 originally comprised rustic farming and fishing villages.
Now, with more than 7.4 million people crammed in a 1,104-square-kilometre (426 sq mile) area, the city is one of the worlds most densely populated places.
The frustration over lack of housing in one of the worlds wealthiest cities is seen in what began as a protest against a bill that would have allowed people to be sent to mainland China for trial and has evolved into demands for greater democracy.
The protests are a manifestation of the growing unhappiness with the lack of consensus, lack of transparency, and dissatisfaction with the governments heavy-handedness, said Yam.
Its all of one piece. And this plan to build artificial islands is a part of that.
Hong Kong has long reclaimed land from the sea, and also has a plan for underground development to free up space.
But the city is not short of land, and only needs better land-use planning to meet its needs, according to the Citizens Task Force on Land Resources, a network of urban planners, researchers and land rights activists.
The governments push for creating new land supply is based on inflated assumptions regarding population growth and space requirements, and ignores the prediction that the citys population is expected to peak in 2043, the organization said.
Nearly 4,000 hectares of land can be unlocked through better planning from existing resources such as the largely-rural New Territories in the north, according to the Citizens Task Force.
Low-lying areas such as artificial islands are highly vulnerable to extreme weather and tides and storm surges, and more frequent flooding, said Paul Zimmerman, chief executive of Designing Hong Kong, an urban think tank.
They would have irreversible impacts on marine and wetland eco-systems, he added.
Cost-effective, less risky alternatives exist, which also have lower ecological impacts. The burden is on the government to prove there is no other alternative.
Chief Executive Lam, in her policy address last year, said the government will initiate feasibility studies on various reclamation sites, including the proposed artificial islands.
From Mumbai to Manila, several Asian cities have reclaimed land from the sea for offices and apartments.
Elsewhere, Denmark said earlier this year it plans to build nine new artificial islands to expand the industrial district of Copenhagen, with construction slated to begin in 2022.
A United Nations-backed partnership is also studying the prospect of floating cities, looking at how platforms at sea might help bail out coastal cities at risk of flooding due to climate change.
But Dubais artificial islands - the World and the Palm projects - which will house luxury hotels and residences, have come under fire for damaging the marine habitat and disrupting currents.
Land reclamation has also been banned or restricted in several countries due to its environmental and other impacts, including rampant sand mining in many parts of Asia.
Hong Kongs plans for East Lantau Metropolis will have similar effects, said Yam.
Wheres the sand going to come from? Its going to destroy another place, and it would have enormous environmental impacts - here and elsewhere, he said.
Ethically and morally - how can you destroy another countrys environment to build this?
The controversy over the plan has brought a range of suggestions from unlikely quarters.
Advocacy group Federation of Public Housing Estates has asked the government to take over an exclusive 172-hectare golf course to create about 30,000 housing units.
A pro-Beijing political party, in a front-page newspaper advertisement earlier this month, suggested using an ordinance to take land from private owners, including in the New Territories, for housing.
Any of these options would be preferable to creating islands, said Yam, as he walked past Mui Wos small shops, cafes and restaurants, and greeted owners and residents.
This is a small town; everyone knows everyone, and we have everything we need right here, he said.
If we build those artificial islands, this will all be gone in a flash.
Reporting by Rina Chandran @rinachandran; Editing by Zoe Tabary. Please credit the Thomson Reuters Foundation, the charitable arm of Thomson Reuters, that covers humanitarian news, women's and LGBT+ rights, human trafficking, property rights, and climate change. Visit http://news.trust.org
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Hilton Honors Points: 5 Luxury Hotels to Get the Most Out of Award Stays – Cond Nast Traveler
Posted: at 7:47 am
Cond Nast Traveler has partnered with CardRatings for our coverage of credit card products. Cond Nast Traveler and CardRatings may receive a commission from card issuers. We don't review or include all companies, or all available products. Moreover, the editorial content on this page was not provided by any of the companies mentioned, and has not been reviewed, approved or otherwise endorsed by any of these entities. Opinions expressed here are entirely those of Cond Nast Traveler's editorial team.
With Hilton Honors points, the loyalty program of the greater Hilton Hotels and Resorts universe, account holders can redeem free nights at 5,000-plus properties at more than 17 brands worldwide, including top-tier locations of Waldorf Astoria and Conrad Hotels.
That sounds like an incredible perk, but figuring out the actual number of Hilton Honors points required to redeem hotel rewards can be quite the task. Generally it depends on a number of factors, from the category under which the hotel falls, to the time of year (peak vs. off-peak season) and length of stay. Each property is its own casetedious, we knowand the number of points required ranges between 5,000 and 125,000. Unfortunately, in 2018 Hilton stopped publishing a straightforward, official award chart and launched an online Points Explorer tool instead. This widget is designed to help account holders see how far their points can take them, based on destination. You could spend hoursactually days, even weeksplaying with the Points Explorer tool to figure out the best way to use your hard-earned Hilton Honors points, but weve done some of that homework for you.
Since the number of points required for a free hotel stay is not pegged to the cash amount of the stay, the value of a reward stay varies greatly. For example, in late October, a room at the Hilton Bentley Miami/South Beach, which retails for $225 per night, will cost you 90,000 points per night; alternatively, a room at the Conrad Bora Bora Nui in French Polynesia, which retails for some $900 per night over the same weekend in October, will cost you the same 90,000 points per night. That's a huge difference in value. In the esoteric world of hotel loyalty, we tend to value Hilton Honors points at roughly a half cent each. So, in the most general sense, any value below that is a bad deal and above, a good deal. In the aforementioned example, youd be cashing out your points for a quarter cent each at the Miami property (bad deal) and one cent each in Bora Bora (amazing deal).
Ultimately, how you spend your points is up to you. With the Hilton Honors American Express Surpass card, for instance, you can get 125,000 bonus points after you spend $2,000 within the first three months of account opening, and it has a low annual fee of $95.
Learn more about signing up for the Hilton Honors American Express Surpass card here.
Once you start racking up Hilton Honors points, a free ultra-luxury stay may be closer than you think. Here are five properties in the Hilton portfolio where your points can go a long, long way.
Opened in July 2019, Waldorf Astoria Maldives Ithaafushi comprises three private islands and 122 villas (including 56 overwater bungalows), all with private infinity pools surrounded by the incredible blue-ombre waters of the Indian Ocean. Nightly rates start at $1,930, but standard room rewards range from 95,000 to 125,000 Hilton Honors points per night. On a recent search for rooms in January 2020 (peak season), we found standard room rewards for the 2,518 square feet King Beach Villa with Pool for 120,000 points per night versus the hotel's best available rate of $2,630 per night.
Current value: 2 cents per point
Formerly The London NYC, the contemporary, all-suite, 564-key Conrad New York Midtown, near Central Park in midtown Manhattan, has rooms larger than most New York City apartments. Rates at the newly renovated and re-branded property begin at $675 per night. Points rewards can be found at 95,000 points per night.
Current value: .71 cents per point
With its sleek suites, buzzy rooftop pool bar, and fantastic Jean-Gorges restaurant, its easy to see why the Waldorf Astoria Beverly Hills ranked No. 1 in our 2017 and 2018 Readers' Choice Awards as the best hotel in L.A. Rooms typically start between $600 and $725 per night (depending on the season) while standard room rewards are fixed at 95,000 points per night.
Current value: .63 to .76 cents per point
Inside a villa bedroom at the Conrad Bora Bora Nui.
Courtesy Conrad Bora Bora Nui
Opened in summer 2017, Conrad Bora Bora Nui is the newest luxury resort in swoon-worthy Bora Bora. Everything about the property screams paradise, but the price tag matches, with rates beginning at $650 or even $1000 per night, depending on the season. Thankfully, points paradise can be found at a fixed 90,000 points per night.
Current value: .72 to 1 cent per point
Often overshadowed by big sister Bora Bora, Moorea, an island in French Polynesia, also impresses with its clear waters and mountainous backdrops. Set on this islands northern shores, Hilton Moorea Lagoon Resort & Spa has stunning villas and panoramic overwater bungalows. Nightly rates run between $600 to $700 and standard room rewards are fixed at 80,000 Hilton Honors points per night.
Current value: .75 to .87 cents per point
Before booking any of these deals, its important to note that redeeming Hilton Honors points may require patience and flexibility, especially if you're going after inventory at standard redemption rates in coveted locations like those mentioned above. Thankfully, Hiltons search engine allows you to easily view inventory over weeks at a time when selecting flexible dates, so you can find the best possible deal for your points.
Cond Nast Traveler has partnered with CardRatings for our coverage of credit card products. Cond Nast Traveler and CardRatings may receive a commission from card issuers.
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Island hopping in Sweden: ‘Pine forests, cobalt rivers and toy-town villages of scarlet wooden cottages’ – Country Life
Posted: at 7:47 am
Sweden has more than 30,000 islands to take in, and many of them are easily accessible from the capital, Stockholm. Sophia Constant took a road trip to find out more.
Ask a Swede about their archipelago and they will enthuse about summers spent roaming wild islands, staying in rustic farmhouses, creating entertainment from nature, keenly fishing for the evenings BBQ, and endless games of Kubb.
Exploring, once a challenge, is becoming easier. Swedes encourage visitors to share their way of life and welcome sustainable tourism, preserving the islands pristine and peaceful allure. Small businesses provide well-managed excursions, and car ferries now connect the islands, enabling seamless road trips.
Credit: Heln pe / mediabank.visitstockholm.com
Wind through pine forests, cross cobalt rivers and explore toy-town villages of scarlet wooden cottages; a natural playground for outdoor pursuits: biking, canoeing, sailing, swimming and fishing necessary skills for islanders worth their salt.
An aerial view of the coastline around Stockholm shows the endless dots on the map.
If youve a long weekend you can explorethree or four of the 30,000 islands; stretch it out to a week and youll also be able to do justice to Stockholm itself. Arlanda Airport is an hour from the gateway to the Archipelago, where Nacka Straits peaceful banks home to a yacht club and sophisticated waterfront restaurants offer a luxurious experience. The outer islands are rustic and rural, and all the more enchanting for it.
Varmdo, the largest island, is home to Artipelag, an extraordinary gallery immersed in forest on the shores of Baggens Bay. The gallery, a work of art inspired by nature, hosts world-class exhibitions, with nature trails leading to external art installations.
Head north to unearth Swedens maritime history at Fredriksborg, once the strongest fortress in Europe. For a typical Swedish sauna and Baltic Sea bathing, take a boat-taxi to private island, Badholmen. Its signature floating pontoon comes with a sauna, speakers, fridge and sofas.
Travel to Rindo to find a cheese factory, craft beer brewery, and Muttley and Jacks micro-roastery. Jack hand-roasts specialty coffees, sustainably farmed, and delivers to cafes across Europe (his canine sidekick, Muttley, snoozes supportively at his feet). His tasting workshops are comparable with fine wine tastings, always concluding with traditional Fika (coffee and pastries) overlooking the Strait of Oxdjupets.
Vaxholm City, capital of the archipelago, boasts a bustling harbour, shops, seafood restaurants and Vaxholm Fortress (prison escape activities are wildly popular). Vaxholm Old Town; an idyllic heritage centre of pastel houses, overlooks families splashing in shallows and picnicking on the boardwalk. Privately charter a boat through serene stretches of the archipelago Catch and Relax combine fishing trips with island history and delicious picnics, or return to owner, Bos, for a Champagne BBQ on a private dock with views to Vaxholm Castle.
Medieval Oscar Fredriksborgs fortification near Vaxholm, in the Stockholm archipelago, Sweden
Vaxholm City is magical over Midsummer, the longest day of the year (19-25 June). This beloved pagan festival, higher-ranking than Christmas, pays tribute to nature and light. Communities, crowned in flower garlands worthy of Renaissance paintings, flock to public parties to enjoy traditional festivities, laced in nostalgia. Dressing the Maypole (ancient fertility symbol), with flowers and birch leaves is a community effort of paramount importance; it forms the centrepiece for the days frivolities.
Ring dances are performed by the older generation, weaving around the Maypole in folk costumes, then the crowd, spellbound by Midsummer spirit, joins hands for the more animated numbers. For any first-timer, the frog dance is obligatory hop in circles to fit in! Gorging on herring-heavy picnics is half the excitement, always accompanied with potatoes, sour cream and mountains of dill, followed by fresh strawberries smothered in cream.
Celebrations culminate in late night family dinners. The sun barely dips below the horizon, weaving the sky with pink and blue, marking the peak of summer. Vaxholm B&B owner, Linda, opens her doors to offer an insight, serving drinks beneath a lantern-lit tree, before a BBQ within a flower-filled greenhouse. Typical of Midsummer, a civilised dinner swiftly morphs to a merry scene of guests around a cornucopia of schnapps, enthusiastically bellowing folk songs, hammering fists to a marching rhythm, bowing to each other with a quick-fire Skl! and knocking back shots. This often leads to Baltic Sea plunges, then dancing to ABBA to warm up. To experience quintessential Midsummer, one must be fully committed
Travel over Midsummer for a fine introduction to archipelago life. The rest of the year its decidedly more sleepy, when nature can be enjoyed in solitude.
A taste of the archipelago within reach of the capital. Spacious, contemporary rooms with balconies overlook the sea (choose the top floor!). The restaurant is worth a visit even if you dont stay:its on a floating platform that enjoys views over the Baltic Sea, overlooking the water taxis darting from pier to pier. Try the seafood platter.
A charming waterfront hotel connected to a historic fortress (climb the look-out tower for 360 views!). Military barracks were converted into homely bedrooms, with wide windows and fireplaces. A 5-bedroom garden cottage with veranda takes in spectacular views.Seasonal food is served in the garden or orangery beneath the fortress, overlooking the shimmering sea magnificent at sunset.
The Wahlstroms transformed a traditional wooden villa into a charming B&B, offering homemade picnics, cookery classes and dinner parties.
This historic hotel in a recently-renovated 100-year-old building offers comfortable sea-view rooms and an excellent restaurant, moments from the Midsummer parade.
Even if art isnt on the agenda, the buffet on the top floor is a place to indulge in an inordinate buffet of meat and fish platters, seasonal vegetables, local cheeses and freshly baked breads.
Sit on the deck with a pot of lemon-drenched shrimps, watching boats bobbing in the harbour.
The well-preserved wooden houses from the turn of the last century in Vaxholm.
Caroline Bugler is spellbound by the Scandinavian landscape painters magical evocation of fjords, villages and mountains.
The most popular songs, the castaway who picked their own records, and why the producers dream of the Queen... and
Randoll Coate bluffed his way into 'labyrinthology' with a chance comment at a dinner party, and ended up making a
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The Best Places to Visit in Greece in October – The National Herald
Posted: at 7:47 am
By My Greek Friend September 24, 2019
Mount Olympus. (Photo: Eurokinissi/Vasilis Sideris)
With cooler temperatures and much reduced crowds, October is a great month for visiting Greece. While most of the islands ritzy resorts and hotels will have closed for the season, Greece still boasts worthwhile vacation spots once the days become shorter. Below are some of the best places to visit in Greece in October:
Lesbos Island
Greeces third largest island features a lush, green landscape unaffected by the commercialism youll find on some Greeces more popular islands. Road trips throughLesbos mountains can take you to a petrified forest, traditional villages and centuries-old churches. The nature is breathtaking and a series of hiking trails wind through forests of olive trees and wild herbs. Because Lesbos has a size-able year-round population, hotels and restaurants stay open throughout the winter. The cuisine is famously good and the island is known for its ouzo and olive oil.
Crete
Located south of Athens, Greeces largest island is a great place to visit in Greece in October. Like Lesvos,Cretehas a size-able year-round population so most hotels, restaurants, shops etc. stay open during the off-season. The October weather is warm and you can expect the sea to stay a nice 23oC.
Cretes picturesque city ofChaniawith its historic quartiers offers charming strolls through Venetian architecture, a perfect fall activity. In northern Crete, you can visit vineyards and sample wine, an island specialty since the Minoan Period! For the adventure-minded traveler, jeep safaris and sailing tours offer fun, interactive ways to explore the island.
Athens
A bustling capital city, Athens may not seem a natural choice for an October trip to Greece. The cooler temperatures, however, will make the climb to the Parthenon and exploring the surrounding sites much easier. The citys chefs will have returned from their island restaurants to choose from. You might even catch a performance at the new Stavros Niarchos Cultural Center, an impressive spot in its own right that offers spectacular panoramic views ofAthens.
Mount Olympus
The highest mountain in Greece and the second highest mountain in the Balkans, Mount Olympus is the mythical home of Zeus and the other major Greek gods. October is the tail-end of the recommended hiking season but guarantees visitors cool temperatures, fall foliage and sights of the 32 species of animals and 105 species of birds that live there. The hike to the summit, Mytika, is easy of you are an experienced mountaineer. Alternatively, there are many easier walks around the mountain that hikers of any level will find interesting. For information about trekking Mount Olympus, arrange to go with (or consult) a guide.
Ios
Largely overshadowed by its glamorous neighbors, Mykonos and Santorini,Iosfeatures the same white-washed architecture but boasts scores of unspoiled beaches, many of which have been protected from further development. In October the party-seeking crowd has long-gone and the atmosphere relaxes with most visitors being couples and families. The water should still warm enough for a swim and youll feel as though you are staying on your own private island!
These are some of the best places to visit in Greece in October; areas where youll experience the more rustic, relaxed, side of Greece.
*This article has been released by My Greek Friend, an online travel agency specializing in creating personalized vacation packages to Greece. You can reach us out via email at info@mygreekfriend.travel , phone on +30 2810247365 or visit our website at http://www.mygreekfriend.travel.
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The Best Places to Visit in Greece in October - The National Herald
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AI uncovers genes linked to heart failure – FierceBiotech
Posted: at 7:46 am
Artificial intelligence has been embraced for its ability to offer insight from big data. By applying the technology to genetics, a research team led by Queen Mary University of London has found clues that they say could aid the development of new drugs for heart failure and identify people at risk of the disease.
Based on an AI analysis of heart MRI images from 17,000 volunteers in UK Biobank, the researchers linked genetic factors to 22% to 39% of abnormalities in the size and function of the hearts left ventricle, which pumps blood into the aorta. They published the findings in the journal Circulation.
The team identified or confirmed 14 regions in the human genome that play a part in determining the size and function of the left ventricle, becausethey contain genes that regulate the early development of heart chambers and the contraction of heart muscle. Enlargement of left ventricle is a condition that can hamper the heart muscles ability to contract and pump blood, putting the patient at high risk of heart attack.
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This study has shown that several genes known to be important in heart failure also appear to regulate the heart size and function in healthy people, said study co-author Steffen Petersen of Queen Mary in a statement. That understanding of the genetic basis of heart structure and function in the general population improves our knowledge of how heart failure evolves.
RELATED:Bayer teams up with AI firm Sensyne Health to mine NHS data for its heart disease pipeline
There is a growing interest in using AI to gain insights into cardiovascular disease. Bayer recently partnered up with Sensyne Health, which uses AI to mine patient data from the U.K. National Health Service, including genomic sequencing data and real-world evidence, to help design clinical studies and accelerate drug discovery.
Many research teams having been looking at different ways to treat heart disease, including using immune therapies and regenerative approaches. Scientists at the University of Pennsylvania, for example,developed genetically modified T cells to attack and remove cardiac fibroblasts, which can lead to cardiac fibrosis. Vanderbilt University researchers identified Roches SYN0012, originally designed to treat rheumatoid arthritis, as a promising candidate that could dampen inflammation of heart tissue after a heart attack. Such inflammation can progress to acute episodes andchronic heart failure.
To help repair damaged cardiac tissue after a heart attack, scientists at the University of Cambridge in the United Kingdom and the University of Washington combined two types of cells derived from human stem cellsheart muscle cells and supportive epicardial cells that help the muscle cells live longer. A team at the the Morgridge Institute for Research previously added a drug called RepSox to stem cells to build better smooth muscle cells that can grow into functional arterial cells.
The Queen Mary researchers believe the 14 regions of the genome they fingered in their new study could be just the beginning of a larger story about genes and heart disease. Our academic and commercial partners are further developing these AI algorithms to analyze other aspects of cardiac structure and function,lead researcher Nay Aung said in the statement.
Aung and colleagues argue the genetic markers theyve already uncovered could help identify those at high risk of developing heart disease or open up new avenues for targeted treatments. The genetic risk scores established from this study could be tested in future studies to create an integrated and personalized risk assessment tool for heart failure, Aung said.
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GSK and AstraZeneca’s PARP Inhibitors Will Flex Their Muscles at ESMO – BioSpace
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PARP inhibitors will be taking center stage at the European Society of Medical Oncology Congress as rival drugmakers aim to show off data that supports broader use of the drug in treating various cancers.
Both AstraZeneca and GlaxoSmithKline will showcase the power of Lynparza (co-developed with Merck) and Zejula, respectively. At ESMO, both companies will highlight clinical data supporting the efficacy and safety of the PARP inhibitors. AstraZeneca will provide details of Lynparza studies in ovarian cancer and prostate cancer, as well as pancreatic cancer. GSK will present Zejula data from its late-stage ovarian cancer trial, as well as data from breast cancer studies.
PARP inhibitors have mainly been tied to cancers that have a BRCA mutation. However, a recent study conducted by UT Southwestern has shown that PARP inhibitors could have broader effectiveness in treating other types of cancer, including ovarian and prostate cancer. PARP stands for poly ADP ribose polymerase, which is an enzyme many cancer cells are more dependent upon than regular, healthy cells are. PARP inhibitors are designed to disable DNA repair pathways in cancer cells, which make it difficult for those cells to survive.
Positive data that is well-received is something both companies need to bolster their oncology programs, an analyst told Reuters. Echoing the UT Southwestern study, John Bowler, an asset manager at Schroders, told Reuters that the utility of PARP inhibitors could become much broader than patients with the BRCA mutation.
That becomes relevant when you start thinking about the drugs role in other tumor types like prostate cancer and breast cancer where the incidence of new patients each year is much greater than in ovarian cancer, Bowler told Reuters.
For GSK, the data could be especially important since the company laid out its new R*D strategy last year that focuses on genetics and the immune system. R&D Head Hal Barron laid out a strategy that focuses on the development of medicines that target mechanisms of action with strong human genetic validations. Those targets have a higher probability of success, which means a shift to a genetics-driven portfolio. Bowler said the data from the Zejula trials will be an important milestone for Barrons strategy. GSK acquired Tesaro Oncology, the maker of Zejula, in December 2018 for $5.1 billion. That bet appears to have paid off. In July, GSK reported that Zejula hit the mark in a Phase III ovarian cancer study. The PRIMA study met its primary endpoint of a statistically significant improvement in progression-free survival for women regardless of their biomarker status. The PRIMA study is one of the Zejula trials that GSK will tout at ESMO.
Not to be outdone, last month AstraZeneca reported that for the second time, Lynparza met its endpoints as a potential first-line treatment for ovarian cancer in a Phase III trial. The Phase III PAOLA-1 trial assessed Lynparza as a companion to the standard of care treatment Bevacizumab (Genentechs Avastin) in women with advanced ovarian cancer. The combination treatment proved to be a powerhouse in the intent-to-treat population with a statistically-significant and clinically-meaningful improvement in progression-free survival.
In its analysis of the PARP field, Reuters predicted that Lynparza will generate about $3.1 billion by 2023, while Zejula will post about $1.1 billion in sales that year.
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1400-year-old Pictish Remains Finally Unearthed in Scotland – Ancient Origins
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Human remains found at what is thought to be a Pictish-era cemetery near Muir of Ord on the Black Isle in the north east of Scotland, have led archaeologists to believe they belong to an ancient Pictish woman. The discovery came as something of a surprise as the scientists say they did not expect to find any human remains in the acidic soil at the site, and the discoverer talked to press about his eureka moment.
The dig was conducted by the North of Scotland Archaeological Society ( NOSAS) and archaeologist Steven Birch told The Scotsman that his discovery had been made on the final day of the dig. He had been working at one particular grave and said he was certain there had been something there.
Aerial view of trench 3 where the remains were found. (Andy Hickle / Tarradale Through Time )
Its really kicking off in the north of Scotland. In August this year I wrote an Ancient Origins news piece about archaeologist Anne MacInnes discovering a massive Pictish symbol stone buried within an early Christian church in Dingwall, less than 10 miles away. Then in September I wrote another article discussing a new study published by researchers from the University of Edinburghs Usher Institute and MRC Human Genetics unit which presented the first comprehensive genetic map ofScottish peoples DNAshowinggenetic linksbetween modern Scots and the Picts.
Now, after aerial photographs suggested the presence of a burial ground , archaeologists from NOSAS spent two weeks uncovering barrows (earthen mounds) over ancient graves to get to the remains of the Pictish person. Mr Birch says he found the human remains near blackened patches in the soil which enticed him to trowel back at that level and to his astonishment the faint outlines of the Picts skeleton emerged after 1400 years.
The faint outlines of a Pict emerged form the dirt. ( Tarradale Through Time )
Mr Birch told reporters I was able to find the legs and the feet, which appear to have been bound together before burial. He then identified the spinal column, the upper arms and shoulders and then the relatively well preserved skull which had partly collapsed. Mr Birch added that he has been an archaeologist for a long time and over the years he has made some important discoveries, "but this was a real eureka moment for me.
This Black Isle excavation is one of the largest Pictish cemeteries in Scotland and is located within the old Pictish province of Fortriu which existed between the 4th and 10th centuries. While traditionally Fortrui was thought to have been located in and aroundStrathearnin centralScotland, James E. Fraser suggests it was in the north of Scotland, centered on Moray andEaster Ross, where most early Pictish monuments are located.
Professor Gordon Noble of the University of Aberdeen is an advisor at the excavation and he told press that Tarradale is one of the largest recorded Pictish barrow cemeteries known about and that the Tarradale Through Time project did a fantastic job revealing and excavating part of the cemetery. It is known that the Picts were a matrilineal society and it is thought maybe this person was a woman of high status for she had been buried in what NOSAS say would have been a very large and imposing barrow.
It is thought this person was a woman of high status. (Tarradale Through Time )
I always find it funny when scientists play with such wholly unscientific subjects such as fate, destiny and superstition. In this instance, Dr Eric Grant, the leader of the archaeological project, told the Scotsman It is a bit of a joke amongst archaeologists that the best finds "always come on the last day and suggests this outcome has been proved on many occasions, he said A few years ago the remains of a Pictish man was discovered in a cave at Rosemarkie , again on the last day of the dig.
And it is not only in the far north of Scotland that archaeologists are adding to our understanding of the Picts, for according to a report in The Scotsman (on "August 23rd 2018) Aberdeen University archaeologists discovered a very significant Class I Pictish symbol stone , similar to the one discovered in Dingwall, featuring carved symbols including a triple disc with cross bar, a mirror, and a notched rectangle with two internal spirals.
Pictish symbol stone found in the River Don in Dyce, Aberdeen, Scotland. (Image: HES)
With human remains being recovered in the north , symbol stones being found in the south and DNA being studied by computers , we are experiencing a Quickening in our knowledge of how these Highland Picts both lived and died.
Top image: Outline of a Pictish burial found near Muir of Ord, Black Isle, Scotland. Source: Tarradale Through Time
By Ashley Cowie
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