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Daily Archives: July 25, 2017
When Will AI Be Better Than Humans at Everything? 352 AI Experts Answer – Singularity Hub
Posted: July 25, 2017 at 12:16 pm
Predictions of when machines will make us obsolete seem to come either from AI evangelists or doom-mongers with little practical experience of the field. Now though, researchers have carried out the largest-ever survey of machine learning experts on the subject.
The advent of AI that can outperform humans at various tasks will have a dramatic impact on society, so forecasting when particular skills or jobs will be automated could be invaluable for policymakers.
But the field is so fiendishly complex and has so many specialized sub-disciplines that there are very few people in a position to forecast when these breakthroughs will come. So instead, researchers at the Oxford Universitys Future of Humanity Institute decided to crowdsource the problem.
They contacted 1,634 researchers who published papers at the 2015 NIPS and ICML conferencesthe two leading machine learning conferencesand asked them to complete a survey on the topic, with 352 researchers responding.
When all the researchers answers were combined, the aggregate forecast was that there is a 50 percent chance that unaided machines can accomplish every task better and more cheaply than human workers within 45 years, and a 10 percent chance of it occurring within nine years.
Interestingly, there was a large discrepancy between the predictions of Asian respondents, who expect this to occur in 30 years, and North Americans, who expect it to take 74 years.
And when the question was worded slightly differently to gauge when all human labor would be automated rather than just when it could be, the aggregate forecast was a 50 percent chance in 122 years from now and a 10 percent chance within 20 years.
The survey also asked for predictions for when a few specific activities would be taken over by machines such as: translating languages (by 2024), writing high-school essays (by 2026), driving a truck (by 2027), working in retail (by 2031), writing a bestselling book (by 2049), and working as a surgeon (by 2053).
However, the usefulness of specific predictions like this is exemplified by the fact that back in 2015 the researchers predicted it would take until 2027 for an AI to beat a human at the board game Go. Google DeepMinds Alpha Go beat a top-ranked professional the following year and the worlds number one this year.
Perhaps more interesting are some of the broader findings of the survey, such as a perception that progress in machine learning is accelerating. More than two-thirds of respondents said progress was faster in the second half of their career and only 10 percent said progress was faster in the first half.
There was little support for one of the mainstays of AI evangelism, though. The intelligence explosion is the idea that once AI reach human-level intelligence, including in developing AI, their ability to operate in parallel and at far greater speeds than humans will lead to rapid growth in their capabilities.
When asked how likely it was that AI would perform vastly better than humans in all tasks two years after machines overtook human capabilities the median probability was just 10 percent. When asked whether there would be explosive global technological improvement after two years the median probability was 20 percent.
Unsurprisingly, the vast majority of respondents thought machines outperforming humans would have a positive impact on humanity. But 48 percent also said there should be more research aimed at minimizing the risks of AI.
While the results of the survey are informative, its important to remember that machine learning researchers are inherently enthusiastic about the technology. That means theyre liable to overestimate the speed of progress, while simultaneously underestimating the potential negative implications.
They are also probably not really qualified to judge how technological advances will interact with things like politics, economics, and human psychology. Just because a machine can do something doesnt necessarily mean it will. There are many other factors involved in determining whether AI will be widely adopted than just technological readiness.
Nevertheless, the perspective of those on the bleeding edge of AI research is an important one. While they may have blind spots, theyre certainly better positioned to pass judgment than many of the commentators weighing in on the debate. Lets just hope their optimism is well-founded.
Image Credit:Stock Media provided by maniaks3D/ Pond5
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AI May Soon Replace Even the Most Elite Consultants – Harvard Business Review
Posted: at 12:16 pm
Executive Summary
Over the next few years, artificial intelligence is going to change the way we all gather information, make decisions and connect with stakeholders. Already, leaders are starting to use artificial intelligence to automate mundane tasks such as calendar maintenance and making phone calls. But AI can also help support decisions in key areas such as human resources, budgeting, marketing, capital allocation, and even corporate strategy long the bastion of bespoke consulting firms and major marketing agencies. According to recent research, the U.S. market for corporate advice alone is nearly $60 billion.Almost all that advice is high cost, human-based, and without the benefit of todays most advanced technologies. A great deal of what is paid for with consulting services is data analysis and presentation. They are very good at this, but AI may soon becomeeven better. Quant Consultants and Robo Advisers will soon offer faster, better, and more profound insights at a fraction of the cost and time of todays consulting firms and other specialized workers.
Amazons Alexa just got a new job. In addition to her other 15,000 skills like playing music and telling knock-knock jokes, she can now also answer economic questions for clients of the Swissglobal financial services company, UBS Group AG.
According to the Wall Street Journal (WSJ), a new partnership between UBS Wealth Management and Amazon allows some of UBSs European wealth-management clients to ask Alexa certain financial and economic questions. Alexa will then answer their queries with the information provided by UBSs chief investment office without even having to pick up the phone or visit a website. And this is likely just Alexas first step into offering business services. Soon she will probably be booking appointments, analyzing markets, maybe evenbuying and selling stocks. While the financial services industry has already begun the shift from active management to passive management, artificial intelligence will move the market even further, to management by smart machines, as in the case of Blackrock, which is rolling computer-driven algorithms and models into more traditional actively-managed funds.
But the financial services industry is just the beginning. Over the next few years, artificial intelligence mayexponentially change the way we all gather information, make decisions, and connect with stakeholders. Hopefully this will be for the better and we will all benefit from timely, comprehensive, and bias-free insights (given research that human beings are prone to a variety of cognitive biases). It will be particularly interesting to see how artificial intelligence affects the decisions of corporate leaders men and women who make the many decisions that affect our everyday lives as customers, employees, partners, and investors.
Already, leaders are starting to use artificial intelligence to automate mundane tasks such as calendar maintenance and making phone calls. But AI can also help support more complex decisions in key areas such as human resources, budgeting, marketing, capital allocation and even corporate strategy long the bastion of bespoke consulting firms such as McKinsey, Bain, and BCG, and the major marketing agencies.
The shift to AI solutions will be a tough pill to swallow for the corporate consulting industry. According to recent research, the U.S. market for corporate advice alone is nearly $60 billion. Almost all that advice is high cost and human-based.
One might argue that corporate clients prefer speaking to their strategy consultants to get high priced, custom-tailored advice that is based on small teams doing expensive and time-consuming work. And we agree that consultants provide insightful advice and guidance. However, a great deal of what is paid for with consulting services is data analysis and presentation. Consultants gather, clean, process, and interpret data from disparate parts of organizations. They are very good at this, but AI is even better. For example, the processing power of four smart consultants with excel spreadsheets is miniscule in comparison to a single smart computer using AI running for an hour, based on continuous, non-stop machine learning.
In todays big data world, AI and machine learning applications already analyze massive amounts of structured and unstructured data and produce insights in a fraction of the time and at a fraction of the cost of consultants in the financial markets. Moreover, machine learning algorithms are capable of building computer models that make sense of complex phenomena by detecting patterns and inferring rules from data a process that is very difficult for even the largest and smartest consulting teams. Perhaps sooner than we think, CEOs couldbe asking, Alexa, what is my product line profitability? or Which customers should I target, and how? rather than calling on elite consultants.
Another area in which leaders will soon be relying on AI is in managing their human capital. Despite the best efforts of many, mentorship, promotion, and compensation decisions are undeniably political. Study after study has shown that deep biases affect how groups like women and minorities are managed. For example, women in business are described in less positive terms than men and receive less helpful feedback. Minorities are less likely to be hired and are more likely to face bias from their managers. These inaccuracies and imbalances in the system only hurt organizations as leaders are less able to nurture the talent of their entire workforce and to appropriately recognize and reward performance. Artificial intelligence can help bring impartiality to these difficult decisions. For example, AI could determine if one group of employees is assessed, managed, or compensated differently. Just imagine: Alexa, does my organization have a gender pay gap? (Of course, AI can only be as unbiased as the data provided to the system.)
In addition, AI is already helping in the customer engagement and marketing arena. Its clear and well documented by the AI patent activities of the big five platforms Apple, Alphabet, Amazon, Facebook and Microsoft that they are using it to market and sell goods and services to us. But they are not alone. Recently, HBR documented how Harley-Davidson was using AI to determine what was working and what wasnt working across various marketing channels. They used this new skill to make resource allocation decisions to different marketing choices, thereby eliminating guesswork. It is only a matter of time until they and others ask, Alexa, where should I spend my marketing budget? to avoid the age-old adage, I know that half my marketing budget is effective, my only question is which half?
AI can also bring value to the budgeting and yearly capital allocation process. Even though markets change dramatically every year, products become obsolete and technology advances, and most businesses allocate their capital the same way year after year. Whether thats due to inertia, unconscious bias, or error, some business units rake in investments while others starve. Even when the management team has committed to a new digital initiative, it usually ends up with the scraps after the declining cash cows are fed. Artificial intelligence can help break through this budgeting black hole by tracking the return on investments by business unit, or by measuring how much is allocated to growing versus declining product lines. Business leaders may soon be asking, Alexa, what percentage of my budget is allocated differently from last year? and more complex questions.
Although many strategic leaders tout their keen intuition, hard work, and years of industry experience, much of this intuition is simply a deeper understanding of data that was historically difficult to gather and expensive to process. Not any longer. Artificial intelligence is rapidly closing this gap, and will soon be able to help human beings push past our processing capabilities and biases. These developments will change many jobs, for example, those of consultants, lawyers, and accountants, whose roles will evolve from analysis to judgement. Arguably, tomorrows elite consultants already sit on your wrist (Siri), on your kitchen counter (Alexa), or in your living room (Google Home).
The bottom line: corporate leaders, knowingly or not, are on the cusp of a major disruption in their sources of advice and information. Quant Consultants and Robo Advisers will offer faster, better, and more profound insights at a fraction of the cost and time of todays consulting firms and other specialized workers. It is likely only a matter of time until all leaders and management teams can askAlexa things like, Who is the biggest risk to me in our key market?, How should we allocate our capital to compete with Amazon? or How should I restructure my board?
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The Power of Artificial Intelligence – A Glimpse at HR’s Future – HuffPost
Posted: at 12:16 pm
Artificial Intelligence has infused its majestic wonders in the business world spread through many industries and niches. From predictive technology and fully automated self-regulating processes, to the way companies manage data and market their products; Artificial Intelligence is as real as peanut butter and jelly sandwiches.
And, its here to stay!
Its 2017. The question is how can companies effectively exploit the absolute potential of the tools available at their disposal, while growing their business and still maintaining a personal connection with the customer base?
Recently, Google has become one of several global powerhouses that are financially backing a new $150 million AI research institute in Toronto, Canada. This also includes $20,000 a year in funding as pledged by The Chan Zuckerberg Initiative, the investment fund of Facebook CEO Mark Zuckerberg and his wife Priscilla Chan.
One of the most interesting areas for AI applicability is Human Resources in the Retail and Hospitality industries, where reducing hiring biases and enforcing complete transparency for acquiring talented individuals is crucial.
Knockri, an innovative young tech start-up from Toronto, Canada is one such example of a company taking AI-based HR solutions by the horns.
The ultimate goal is to be able to help every recruiting team in the world, who require strong front-line customer service talent. Our AI system for HR uses audio and videoanalysis, assessing personality attributes to gauge how fit an applicant would be for a position based on employer feedback, industryknowledge and scientificallybacked data, says Jahanzaib Ansari, the companys CEO.
The software system does not eliminate the person to person interview; it only acts as a highly intelligent screening tool, allowing employers to get the best applicant to the interview a lot quicker. Since its founding in 2016, the start-up is already disrupting the retail and hospitality industry by saving employers an immense amount of time and money in the screening and short-listing process of hiring by using the power of AI.
The company is further enhancing their system alongside IBM Watsons cutting edge Artificial Intelligence technology, based out of IBMsInnovation Space in Toronto.
Artificial Intelligence has the potential to have an enormous impact on the Human Resources industry.
Here are 5 ways that stand out:
1. Personalization: Personalizing the process of learning at the corporate level and recording critical employee data relating to a broad spectrum of behaviours and learning patterns.
2. Improved Recruitment: HR is a highly human-centric realm. Since human beings are complicated creatures, its very hard to acquire basic analysis-focused data on individuals during the hiring process. This is where AI helps in predictive analytics using natural language, thus speeding up the recruitment process by empowering businesses to weed out undesirable candidates faster, while committing far fewer mistakes.
3. Workflow Automation: AI is poised to be a game-changer when it comes to workflow problems. Automating processes like interview scheduling, employee performance reviews, employee on-boarding, and even the answering of basic HR questions - all fall under this category.
4. Better prediction models: Prediction models are vital in improving efficiency, productivity and overall cost effectiveness for any organization. This is where AI works its magic by analyzing turnover rates, internal employee engagement levels and communications or any other unforeseen problems that could take months or years to be visibly surface. Artificial Intelligence will always be one step ahead of companies themselves.
5. Reducing Hiring Biases: The quality of data that a companys AI is being trained on is really important. One of AIs fundamental goals should naturally be to help companies build a stronger & more diverse workforce.This means that the data being used to train the AI should be as unbiased as possible, so it can really help businesses increase their employment equity in an honest way.
With a lot of retail brick and mortars shutting down, a huge focus has been put on the in-store customer experience.
It is critical that employers get the best applicant for a position 10x quicker by using technologies and software that work as an enabler; making daily operations alot more efficient via the power of AI, instead of replacing the traditional recruiter altogether.
So whats the take-away here?
HR professionals need to embrace big data, so they can be prepared to adapt the profound technological advancements in AI that are set to revolutionise the recruitment industry forever!
With the fast paced and ever evolving world of business going through tremendous technological changes, it is imperative that companies around the globe - particularly those in the HR, Retail and Hospitality industries - understand, employ and effectively apply the power of Artificial Intelligence.
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Artificial Intelligence: The New Impulse For Alphabet – Seeking Alpha
Posted: at 12:16 pm
An important shift from a mobile first world to an AI first world
Google CEO, Sundar Pichai
The active investments of Alphabet (NASDAQ:GOOG) (NASDAQ:GOOGL) in the artificial intelligence market, the growth rate of which over the next decade will be four times higher than that of the digital advertising market, increase the long-term investment attractiveness of the company.
To begin, let's take a look at the current growth forecasts for the global Artificial Intelligence (AI) market in the coming decade.
Here is information provided by Statista:
For a better clarity, Ive slightly modified these data and projected the trend until the year 2030. Here is what Ive got: over the next 15 years, this market will be growing at the CAGR of 40%, and in the next 10 years, it will be increasing by an average of 50% each year:
Tractica forecast (a market intelligence firm that focuses on human interaction with technology) is a bit more modest, but it still suggests that the annual worldwide AI revenue will grow from $643.7 million in 2016 to $36.8 billion by 2025, demonstrating a CAGR of 49.88%:
So, the growth in the next decade at an average annual rate of 50% - is really a lot?
It depends on what to compare with, but given that I'm performing this analysis through the prism of perspectives for Alphabet, it probably makes sense to compare AI with digital advertising market, which is accountable for 87% of Googles revenue.
As we can see, according to eMarketers data and assuming the trend will persist, in the coming decade this market will be growing at an average annual rate of 12.3%, i.e. four times slower than the AI market:
Also, Alphabet is one of the market leaders in cloud computing, therefore, I propose to compare the growth rate of this market with AI as well.
According to the Wikibon enterprise cloud spending will be growing at a CAGR of 19% between 2016 and 2026:
Approximately, the same forecast for the next five years was given by IDC:
So, in the horizon of the coming decade, the rates of growth of the AI market will be at least twice higher than those of the cloud computing market and four times higher than those of the digital advertising market. The most obvious conclusion from this: In order to ensure a double-digit annual growth rate in the next ten years, Alphabet needs to actively invest in the AI market. The good news for the owners of Alphabet shares is that the company is already actively doing it.
Starting with 2012, Alphabet acquired 11 startups specializing in AI, which exceeds the number of similar acquisitions by Microsoft (MSFT) and Facebook (FB) combined:
However, it should be remembered that the quantity does not always turn into quality. Nevertheless, if you judge about the success of Alphabet in the field of AI by the level of artificial intelligence of Google Voice Assistant, it becomes clear that the company is currently in a position of a leader.
According to the March study conducted by Stone Temple, that compared the quality of the responses of intelligent assistants developed by Alphabet (Google Assistant), Microsoft (Cortana), Apple (AAPL) (Siri) and Amazon (AMZN) (Alexa), Google Assistant gave answers to the biggest number of questions, and also made the smallest number of mistakes:
It has been observed that not the fastest runner wins a long distance race, but the one who starts earlier. The AI market is an incredibly long "distance," but, apparently, Alphabet has started this "race" first and is already a leader.
Moreover, Alphabet, being the most popular global search engine with an enormous amount of data, has all chances to remain on a leading position in the artificial intelligence market in the long term, and it will be the companys growth driver for the next decade.
P.S. I have recently published my version of Alphabet's valuation through the DCF analysis, and I came to the conclusion that, given the most conservative prediction parameters and the revenue growth at a CAGR of 12.5% in the next ten years, the fair price of the companys shares will be at least 30% above the current level. Considering the figures provided in this article, I will probably have to review the DCF model, increasing the revenue growth forecasts. Of course, this will enhance the growth potential of the company's share price.
Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.
I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.
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Brainpower is so yesterday leave it to AI – Kansas City Star
Posted: at 12:16 pm
Kansas City Star | Brainpower is so yesterday leave it to AI Kansas City Star Smart people are starting to worry about the brainpower of machines. A recent report from Harvard said the emergence of artificial intelligence as a weapon poses as much game-changing potential as the airplane and the nuclear bomb. They worry it could ... |
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Highflying Artificial Intelligence Chip Play Seen Flying Even Higher – Investor’s Business Daily
Posted: at 12:16 pm
Highflying chip stock Nvidia (NVDA) received a bullish report on Monday from investment bank Canaccord Genuity forits booming data-center processor business.
XAutoplay: On | OffCanaccord analyst Matthew Ramsay reiterated his buy rating on Nvidia and raised his price target on the stock to 180 from 155.
Nvidia shares fell1.2% to close at 166.15 on the stock market today. It droppedan additional 1.4% in after-hours trading Monday. Nvidia hit an all-time high of 169.30 on Friday.
Nvidia has diversified from graphics processors for PCs and gaming consoles into high-end computing processors for data centers, artificial intelligence, machine learning and self-driving cars.
"Our overall bullish thesis on GPU (graphics processing unit) computing continues to accelerate (particularly data center) and we believe Nvidia's emergence as a platform computing company (of which gaming is just one important piece) is now cemented," Ramsay said in a note to clients.
IBD'S TAKE: Nvidia is one of eight chip industry companies on the IBD 50 list of top-performing growth stocks. It is currently ranked No. 6.
Nvidia should be able to hold its own against increased competition in the data-center market from Intel (INTC) and Advanced Micro Devices (AMD), Ramsay said.
"We remain very impressed how quickly Nvidia has segmented the product roadmap to provide more application-specific silicon to both the quickly evolving data-center and automotive markets," he said.
On Saturday,at the annual Computer Vision and Pattern Recognition conference in Honolulu, Nvidia Chief ExecutiveJensen Huang unveil the company's latest GPU, the Nvidia Tesla V100, based on its Volta architecture.
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Patients recognise over-worked GPs as majority agree to see alternative medical professionals – Herald Series
Posted: at 12:13 pm
WITH primary care on the brink of change, a county-wide survey has revealed a majority of patients would be happy to see someone else instead of their GP.
Mounting pressures, lack of funds and increasing workloads has forced a re-think of the way primary care and GP services are provided across the county.
Now in its most recent survey, Healthwatch Oxfordshire, has found that 72 per cent of patients would be happy to see an alternative medical professional other than their GP.
In its Peoples Experiences of Using GP Services in Oxfordshire report, the watchdog also found that 39 per cent of patients had contacted a pharmacist before seeing a GP for medical advice.
Reasons cited for not seeking help from either a nurse practitioner, pharmacist or physiotherapist was because patients needed management of long-term conditions or the inability of a nurse to be able to prescribe medicine.
Director at Healthwatch Eddie Duller said: There is a change of heart from the public in that they recognise that GPs are stretched and under pressure, like most people at work in todays world.
Some are open to new ways of seeing the doctor, or at least getting some form of advice and treatment from practice nurses and the neighbourhood chemist.
The survey, completed by more than 400 patients across 67 practices, showed that a greater proportion waited four weeks for an appointment than in 2014.
Mr Duller added: Thats just as well because medical help closest to home could change out of all recognition in the next five years because of a reorganisation being powered through by the Oxfordshire Clinical Commissioning Group (CCG), which pays for GP and related services.
They say the aim is to improve access to the first layer of care, but that doesnt necessarily mean you will see a doctor.
There are plans to increase the skills of nurses and other medical practitioners such as pharmacists and physiotherapists to cut down the doctors workload.
GP practices are being encouraged to work together to serve populations of 30 to 50,000 organised through central hubs in areas roughly similar to town and district council areas.
The report lays out recommendations for the CCG, including promises to ensure that all GP surgeries will offer appointments within a week of a patient asking for one and that every surgery should have an active Patient Participation Group.
Change is afoot in primary care as plans to shake-up services will be revealed after a decision is made on the first phase of Oxfordshires Sustainability and Transformation Partnership (STP) on August 10.
The STP aims to address a growing financial shortfall and the needs of an ageing population.
For Mr Dullers in-depth response and analysis on the future of primary care and GP practices turn to page 12.
A spokesman for the CCG:The Primary Care transformation plan describes the direction of Primary Care over the next 5 years.
"The main needs are to stabilise general practice, remove financial risk upon practices and encourage the work force to remain within Primary Care.
"This needs to be done alongside maintaining the tradition role of Primary Care to act as the main entry point into the health care system and delivering timely access and quality care.
The plans describes a number of measures that are already in place such as recruitment support for GP practices, same day access hubs offering additional appointments in hours and at weekends, piloting pharmacists in practices.
"It also describes short to medium term initiatives that could be implemented such as urgent community visits, commissioning of integrated community nursing teams, social prescribing, development of lifestyle centres, however, all of these ideas would need to be tested with patients and the public in the work that is being undertaken in Phase 2 of the Oxfordshire Transformation Programme.
Each CCG locality has reviewed the framework and both the Primary Care Patient Advisory Group and the Health Overview and Scrutiny Committee have reviewed and inputted to earlier drafts.
"The aim, once agreed, is to further develop within localities involving other stakeholders such as Federations and Oxford Health with invitations to social care and Oxford University Hospitals Trust.
"This work will take place between July and September with the purpose of producing locality place based plans for Primary Care which will feed into Phase 2 of the Oxfordshire Transformation Programme.
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Get Pink: Bond between patient, provider helps woman through breast cancer fight – KOKH FOX25
Posted: at 12:13 pm
(Courtesy of Sherry Quiring)
Beautiful things are often born out of adversity. In this case, it's an unbreakable bond between two women brought together by a vicious disease and an unshakable faith.
For nine long months, Sherry Quiring and Juli Johnson, an APRN at the INTEGRIS Cancer Institute, walked side by side, exploring the halls and the many options surrounding Sherry's diagnosis.
"First diagnosed in February 2016, Quiring said. It came as a shock. It was found during a routine mammogram."
That mammogram would be the first step towards saving her life, as it caught her triple negative breast cancer early. But an aggressive cancer requires aggressive treatment, and Sherry would learn that in the weeks and months to come. She first underwent a lumpectomy, followed by six months of chemotherapy and six weeks of radiation.
"I managed it really pretty well through some good nausea medicine, some incredible faith in my lord and my savior and my family and my friends, Quiring said.
And with the guidance of Juli, who is an integrative medicine provider focused on treating the mind, body and spirit.
"Integrative medicine is a little different then just alternative medicine because we're going to use conventional medicine and add alternative modalities, Johnson explained.
Those include things acupuncture, massage and yoga. All of which Sherry did her best to incorporate into her own treatment. She now credits that, along with her faith and her family with helping her through every step of the way.
"I believe the whole package of things that I did helped me get where I am now, which is really feeling good again and enjoying life, Sherry said.
Instead of telling people she's in remission, Sherry prefers to tell them she's cured and she's lived each day since with that mindset.
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Merck, Samsung Bioepis launch discounted US Remicade alternative – CNBC
Posted: at 12:13 pm
Merck and South Korea's Samsung Bioepis said on Monday they have begun selling a less expensive alternative version of Johnson & Johnson's rheumatoid arthritis drug Remicade in the United States, a move that should accelerate price declines for the big-selling medicine.
The U.S. and Korean drugmakers said they would sell their version, to be called Renflexis, at 35 percent discount to the list price of J&J's top-selling medicine, or about $735 for a 100 milligram dose.
J&J shares were down 1.6 percent at $133.16.
Renflexis is the second U.S. biosimilar version of Remicade to be sold after Pfizer launched its Inflectra late last year at a 15 percent discount to J&J's list price, later dropped to a 19 percent discount.
Remicade had U.S. sales of $4.8 billion last year. They fell 8.2 percent for the first half of 2017 to $2.2 billion with the new competition.
As with generic medicines, once multiple biosimilars of a drug become available prices are expected to drop more quickly. Many industry executives and analysts have expressed surprise at how fast prices have fallen in Europe, which led the way with biosimilars.
Merck sells the branded version of Remicade outside the United States. In Europe, it is already facing competition from biosimilar Remicade and cheaper versions of other medicines in the class.
Many companies are developing a wide range of biosimilar versions of top-selling biologic medicines, including major biotechs like Amgen, which is working on cheaper versions of several of its rivals' blockbuster drugs.
J&J, in a statement, said it offers a variety of discounts and rebates off the list price of Remicade, giving it an average sales price of $808.87 per 100mg vial.
J&J's Janssen unit sought a preliminary or permanent U.S. injunction to block the Bioepis version, arguing that it infringed three of its patents. A hearing for the lawsuit has yet to be scheduled.
"We are confident we do not infringe on Janssen's patents," Samsung Bioepis spokesman Mingi Hyun said.
Renflexis, which received U.S. approval in April, is the first medicine available in the United States under a global biosimilars agreement between Merck and Samsung Bioepis, a unit of Samsung BioLogics.
Since it is not possible to make exact copies of complex biotech medicines, which are manufactured from living cells, they cannot be called true generics as with simple pills. Instead, companies must prove their versions are similar enough to the original medicine.
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Merck, Samsung Bioepis launch discounted US Remicade alternative - CNBC
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Food-based iodine during pregnancy important for child brain development – NutraIngredients.com
Posted: at 12:12 pm
By Tim CutcliffeTim Cutcliffe , 25-Jul-20172017-07-25T00:00:00Z Last updated on 25-Jul-2017 at 17:53 GMT2017-07-25T17:53:17Z
Low levels of maternal iodine may be linked to reduced brain development at age three, a new study has suggested.
The study, published in The Journal of Nutrition,was a collaboration between the Norwegian institute of Public Health, Oslo and Akershus University College of Applied Sciences and TINE SA and used data from the Norwegian Mother and Child Cohort Study (MoBA).
They found that children whose mothers had low dietary iodine intakes during pregnancy were more likely to experience various symptoms of impaired brain development.
Maternal iodine intake below the Estimated Average Requirement (EAR) during pregnancy was associated with symptoms of child language delay, behaviour problems, and reduced fine motor skills at 3 y of age, concluded lead author Marianne Abel from the Research and Development department of TINE SA.
In the main analysis, the study evaluated iodine intake solely from food. Participants were divided into those consuming either less than, or more than 160 micrograms per day (ug/d), the EAR recommended by the National Academy of Medicine (formerly the Institute of Medicine)
The study also observed a dose response relationship between maternal iodine intake and behavioural problems, with odds ratio for this outcome rising particularly steeply for dietary intakes below 100 ug/d.
The results of this study emphasize the urgent need for preventing inadequate iodine intake in women of childbearing age to secure optimal brain development in children, recommended Abel.
The team also carried out separate analysis on mothers taking iodine supplements of up to 200 ug/d.
The results showed no evidence of a protective effect of iodine supplementation during pregnancy, commented the researchers.
For mothers in the low intake group (<160 ug/d), supplementation was linked to negative effects.
In those reporting first use in gestational weeks 012, supplement use was associated with an increased risk of externalising behaviour problems, reported the researchers.
Similarly, starting supplementation in the second trimester was linked to a higher risk of internalising behaviour problems.
The study authors speculated on various possible reasons for the lack of beneficial, and potentially harmful, effects of supplementation.
Initiating supplement use during pregnancy might be too late and may also provide less iodine than needed to compensate for the effects of a depleted iodine store on thyroid function, they suggested.
A sudden increase in iodine intake [from supplements], although modest and within the recommendations, might also lead to a stunning effect, with transient inhibition of maternal or foetal thyroid hormone production.
In the study, researchers used iodine consumption calculated from a Food Frequency Questionnaire (FFQ) (specifically designed for MoBa) to measure intake, rather than Urinary Iodine Concentration (UIC). Validation studies showed a good correlation between the two exposure measures, indicating that FFQ is an adequate long-term measure for iodine status.
FFQ correlation coefficients for the calculated iodine intake and major iodine food sources were higher than for most other foods and nutrients, indicating a regular consumption pattern of food items containing iodine, wrote the researchers.
The researchers emphasised the importance of long-term, rather than short-term iodine status; and that securing long-term adequate dietary (rather than supplemental) intake before pregnancy is essential to promote healthy brain development in children.
Source: The Journal of Nutrition Volume 147, issue 7. Pages 1314-1324 doi: 10.3945/jn.117.250456 Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study Authors: Marianne H Abel, Anne-Lise Brantsaeter et al
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