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Daily Archives: April 21, 2017
The Guardian view on protein modelling: the answer to life, the universe and everything – The Guardian
Posted: April 21, 2017 at 2:39 am
Designing medicines to target diseases requires knowing what proteins are involved and their form. Scientists have identified a protein which is a key driver for the growth and spread of breast cancer. Photograph: Rui Vieira/PA
When Eliezer Yudkowsky, one of the worlds top artificial intelligence theorists, mused about how superintelligent robots might wipe out humans he speculated that perhaps they would solve one of the sciences holy grails: predicting protein structure from DNA information. In Mr Yudkowskys words these robots would then synthesise customised proteins ... building even more sophisticated molecular machines. Imagine tiny invisible synthetic bacteria, with tiny onboard computers, hiding inside your bloodstream and everyone elses. And then, simultaneously, they release one microgram of botulinum toxin. Everyone just falls over dead. Mr Yudkowskys apocalyptic scenario rests on something science has pondered with no answer for decades: why cant we say what determines a proteins shape?
This is not some idle speculation. Proteins are the bedrock of living systems, intimately involved in every physiological process from triggering an immune response to thinking. Good health requires a fine balance of proteins. An imbalance, and disease often strikes. Cancer is traced to an overproduction of proteins. Misfolding proteins have been linked to type 2 diabetes, while the strange bundling of them is thought to be behind the death of brain cells in Parkinsons disease. Proteins function is dependent on their form, which is the result of a folding up of hundreds of amino acids its constituent parts into a specific and complex 3D structure. That configuration determines what the protein does: whether it becomes an enzyme to accelerate a chemical reaction; or a receptor passing signals to a cells molecular machinery. Crucially, a drug can alter a proteins function by binding to it in a particular spot. Designing medicines to target diseases requires knowing what proteins are involved and their form. After a half century we can identify 100,000 protein shapes. But we have a database of 100m proteins. That is why we have few molecular keys capable of picking the lock to understanding disease-causing proteins.
Why has protein structure proved so hard to crack? They can be probed with x-rays, but that means first purifying proteins and then growing them as crystals in a laboratory. Its a lengthy process. Some do not seem to crystallise at all. There are glimmers of hope. David Jones at Britains Francis Crick institute, which has just been awarded a 2m European grant, uses new computational techniques to predict novel protein structures. But the real prize is the one Mr Yudkowsky identified: by looking at DNA, could one predict the shape of the proteins it released? Since DNA encodes the amino-acid building blocks of an organisms proteins, we know their composition. This is not much help with their structure. Human proteins can fold up in an astonishing number of ways: about a googol cubed or 10 to the power of 300. Theres not enough computing power to work out all these possibilities and thus find the optimum. Less than 10% of human DNA codes and regulates proteins. But we have no idea how altering the gene sequences changes proteins forms and functions. If we did understand it so that we could tamper with it to our advantage, then it would likely lead to all sorts of ethical dilemmas such as growing older without ageing. Maybe that is why Mr Yudkowsky considered it a task only solvable by a superintelligence so clever that its very existence might spell our end.
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Waste Cadets: space plans mean more space junk, harder space exploration – Space Daily
Posted: at 2:39 am
Plans by private space explorers to launch "mega constellations" of thousands of communications satellites to allow for global wireless services could lead to a rise in collisions and buildup of dangerous space junk in Earth's orbit, a study has warned, suggesting corporate interest in space is perhaps somewhat sky high.
A variety of companies, including Google, SpaceX, Boeing and Samsung, are vying to launch global broadband networks via the deployment of thousands of micro satellites into low orbit. The first launches are planned for 2018.
However, a team of Southampton University researchers, led by Dr. Hugh Lewis, senior lecturer in aerospace engineering, have concluded the results could well be calamitous. The group ran a 200-year simulation to assess possible consequences of such a rise in orbital traffic, concluding it could create a 50 percent increase in the number of catastrophic satellite collisions.
Such crashes would likely produce a further increase in the amount of space junk orbiting the Earth, raising the prospect of further collisions and potential damage to the services the satellites were intended to provide.
"The constellations that are due to be deployed from next year contain an unprecedented number of satellites, and a constellation launched without much thought will see a significant impact on the space environment because of the increased rate of collisions that might occur," Dr. Lewis said.
With approximately 750,000 objects larger than one centimeter orbiting Earth, junk surrounding the planet is already a major obstacle to attempts to explore space. At average speeds of 40,000 kilometers per hour, impacts on space hardware would deliver roughly the energy equivalent to the explosion of a hand grenade, with potentially dramatic consequences for operational satellites.
The team's research was funded by the European Space Agency, which is now calling for all satellites planned for orbital mega-constellations to be able to move to low altitudes once their missions are over, so they burn up in Earth's atmosphere. The ESA state they should also be able discharge all batteries, fuel tanks and pressure tanks to prevent explosions that would scatter debris.
Dr. Holger Krag, head of the Agency's space debris office, said many companies proposing to launch services provided by such mega constellations lacked experience of the difficulties of working in Earth's orbit.
Moreover, Dr. Krag expressed concern at ambitions to manufacture satellites at a fraction of the cost and many times the rate of traditional taxpayer-funded spacecraft, while still meeting exacting guidelines for their post-mission disposal.
"Right now, under all the taxpayer-funded space flight we are doing today is only able to achieve 60 percent of success rate for that maneuver. How can they be better under commercial pressure and with cheaper satellites? That's the worry we have," he said.
Dr. Lewis is to present his research at the ESA center in Darmsadt, Germany, where some of the aspirant private space explorers will also be in attendance.
"Even with good intentions it remains an extremely high technological challenge to manage to [meet ESA proposals]. Let them achieve a success rate of 90 percent, which would be extremely good compared with what we do now, and it still means a few hundred satellites will be lost and at that altitude it's not good. It's as simple as that," Dr. Krag concluded.
Exacerbating the situation, Dr. Lewis believes, is a lack of a dedicated international body dealing with the issue of space junk.
"Junk is dangerous. While some will de-orbit naturally after 5-10 years, some will drift indefinitely. Disposal isn't easy either - even to get a ship into orbit is very costly, and then there's the issue of securing the junk in space before you can even consider getting rid of it," Dr. Lewis told Sputnik.
However, he adds that research into these issues is significant and ongoing - the end result could be spacecraft equipped with retrieval solutions similar to those seen in science fiction movies. Another option is "in-orbit" servicing, which would mean satellites could be upgraded and repaired in space - meaning few if any satellites will be reduced to junk status.
"In-orbit servicing is the next big thing. However, there are a number of challenges to achieving that goal - and another issue is upgrading old satellites that aren't equipped for updates. It's difficult to interact with an object that is not prepared for it. We need to ensure in our quest to clean up the junk that we don't add more and make the problem worse."
Source: Sputnik News
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Waste Cadets: space plans mean more space junk, harder space exploration - Space Daily
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Machines, not people, should be exploring the stars for now – CNN
Posted: at 2:39 am
In their own way, Musk and Glenn each represent the hopes and dreams of those who delight in the idea of mankind leaving the bounds of Earth and exploring the solar system and, ultimately, the stars.
Over the past 50 years, we've seen men first orbit the globe and then walk on the moon. We were gripped b the fictional journeys of the Starship Enterprise, which explored the galaxy, encountering new life and new civilizations. Popcorn in hand, we watched Matt Damon struggle to survive in "The Martian."
We have dreamed of a time when humans can travel through space as readily as when early mariners unfurled their sails and headed west in search of new lands. But we might not have stopped and asked an important question.
Now, I am not asking whether we should explore the universe. I also dream of the day that we become galactic citizens. The question is whether the initial exploration of space should be done by humans or by robots. I would argue that, for the moment, robotic exploration should have the upper hand.
Proponents of the astronaut-preferred camp point, quite rightfully, at the versatility and independence of humans. Fans of human spaceflight are certainly correct when they remind us that humans are highly versatile. People observe the conditions around them and can react to circumstances as needed.
However, people are also fragile. They need food, water, and air. They can exist in only a narrow range of temperatures and find inhospitable both vacuums and a radioactive environment. While some adventurers might prefer to remain in space forever, many of them expect to land gently back on Earth. All of these considerations are extremely challenging and not important for robotic missions.
Possible manned missions to Mars are imagined to cost about $1 trillion, with the outcome being limited exploration of the Red Planet by about 2030 (with some estimates saying 2050). And a mission with that price tag would hamstring the rest of the space program.
In contrast, robotic exploration of the solar system is far less costly. The Cassini mission to Saturn cost about $3.2 billion. The Mars Curiosity Rover cost about $2.5 billion. These and other missions have been wildly successful in teaching us about places where literally no one has gone before. Mars missions have explored ancient streams where knee-deep water once flowed and have found organic carbon embedded in surface rocks.
In addition, there are methods for exploring the cosmos that don't require actually going to the place under study. The Hubble telescope, has perhaps revealed more about the universe than any other scientific instrument, cost about $14 billion, including imaging the first galaxies formed and played a key role in the discovery that the expansion of the universe is accelerating. And the wildly successful planet-hunting Kepler satellite weighs in at under $1 billion.
Manned programs can cost tens or hundreds of times more than the robotic missions.
But it's not just about the money. There are three important goals we need to achieve from our space program. The first is monitoring our own world, resulting in storm warnings and help in understanding our complex planet, which can best be done by tireless satellites orbiting the Earth. The second is to learn more about our solar system and the more distant universe. On this, the case is also clear: robotic exploration, through either space probes or telescopes, provides a much better yield for much lower money.
The final goal is that of making humanity a multiplanetary species. By definition, this includes manned spaceflight, but the question is really how we should achieve that objective.
Developing human space-faring technology is crucial, but first we need to decide where to go. The moon is a dead planet and Mars is not nearly as welcoming as the New World was to the Spanish explorers. In fact, there is no place in our solar system where pioneers can simply drop seeds in the soil and wait for food to pop out of the ground. For that, we need to look at distant stars.
And interstellar exploration is also something in which robots will lead the way. Following the identification of a possibly habitable planet by the Kepler satellite or perhaps PLATO, a European Space Agency planet-hunting telescope scheduled to be launched in 2024, the next step would be a survey of the planetary system by an unmanned probe.
And if we chose to explore the nearest sun-like star, the signal transit time is more like 24 years. With a multiyear time lag between messages, the interstellar probe will have to be able to execute independent judgment.
Only once a habitable planet is identified by these robotic approaches, will it be the time for a manned mission. With a welcoming destination beckoning to them, a team of intrepid men and women will leave the solar system and strike out for a new home. And, at that moment, homo interstellaris will come of age.
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Machines, not people, should be exploring the stars for now - CNN
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UMass Lowell looks ahead to our future in space – The Boston Globe
Posted: at 2:39 am
The future of space exploration and technology is a hot topic these days, fueling blockbuster movies and heightening attention about travel to Mars and other planets one day.
On Friday and Saturday, the University of Massachusetts Lowell is convening scientists, former astronauts, and industry leaders for two days of talks on the topic. The symposium Space Exploration in the Upcoming Decade: The Domestication of Space is presented by the colleges Center for Space, Science, and Technology.
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Much has changed since the center held an event 10 years ago to mark the 50-year anniversary of the start of the Space Age, a period begun by the famous 1957 launch of the Soviet satellite Sputnik, said the centers director, Supriya Chakrabarti.
When we first met 10 years ago, we didnt predict how accessible space would become, Chakrabarti said. The rise of private companies like SpaceX, Blue Origin, and others operating in space and taking people up into space, its a big change.
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These talks and panels are going to touch on the way space has changed and the new areas that have opened up, he said.
Speakers include: James Abrahamson, former designated astronaut and former associate director of NASA; Robert Cabana, former astronaut and current director of the Kennedy Space Center; and John Connolly, leader of NASAs Mars Study Capability Team.
The subject of sending humans to Mars is topical, as nations and private companies explore the possibility of missions, Chakrabarti said. The United Arab Emirates is planning to launch a satellite in 2020 and SpaceX founder and CEO Elon Musk is asking for volunteers for a potential one-way trip.
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Getting someone to Mars is feasible, Chakrabarti said. Its the getting them back that poses much of the problem.
To get to Mars, there are two main things to keep in mind the launching and the landing. To get someone back, you need to do even more planning and pack the required fuel, he said.
In spite of all the challenges that face humanity in space, Chakrabarti said, he remains hopeful that a bright future awaits.
Were doing things that we couldnt have even imagined 10 years ago, he said. The tools are so much more sophisticated and my students are so good at using them. Theyre so passionate.
I was 4 when Sputnik launched and now Ive built instruments that are now on the International Space Station, he added. Its great fun.
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UMass Lowell looks ahead to our future in space - The Boston Globe
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Dealing with e-waste the nanotech way – eco-business.com
Posted: at 2:39 am
Printed circuit boards (PCBs) can now be pulverised into other useful materials. Image: Christian Taube , CC BY 3.0, via Wikimedia Commons
By Madhukara Putty, SciDev.net
Printed circuit boards (PCBs) are best recycled by pulverising them into nanosized particles to easily recover valuable constituents such as polymers, oxides and metals, say Indian researchers.
The new method, described in astudypublished inMaterials Todayin March, is scalable andenvironment-friendly, said researchers from the Indian Institute of Science (IISc), Bangalore, and the Rice University in Houston, US.
In the study, the researchers followed the principle that ultra-low temperatures make materials brittle and are easy to pulverise and separate.
They placed a PCB in a rotating cylinder with temperatures brought down to minus 119 degrees Celsius before bombarding it with steel balls to shatter it into nanoparticles which were then dispersed in water.
The nanoparticles could be put to various uses, the researchers said. They could be added to polymer composites strengthening them, used in 3D printing or in the making of polymer powder-based paints.
Metallic nanoparticles can be reused after purification by well-known methods.
With some preliminary sorting, the method can handle most PCBs, says Kamanio Chattopadhyay, research guide, professor at IISc and an author of the study.
Although thetechnologyis still in the laboratory stage, the research team is now working with an industry to demonstrate its scalability and effectiveness.
With some preliminary sorting, the method can handle most PCBs.
Kamanio Chattopadhyay, research guide and professor, India Institute of Science
Scaling up the process depends on factors such as the existence of an efficient supply chain of waste as well as viable business models including the availability of capital, expected return and the policy environment, says Chattopadhyay.
Others are less optimistic.
Physical crushing requires a lot of energy, especially when dealing with complex circuit boards with a variety of components.
Smelting circuit boards is more economical and feasible, says R. Parthasarathi, managing director of E-Parisara, one of Indias leading e-waste recycling companies.
According to theUnited Nations University, the world produced 42 million tonnes of e-waste in 2014, with Asia accounting for 16 million tonnes.
Currently e-waste is dumped in landfills, incinerated or treated with chemicals to recover valuable materials, but these are not regarded as environment-friendly processes. This piece was produced by SciDev.Nets Asia & Pacific desk.
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Novartis licenses nanotech platform in search of diabetes therapy – The Pharma Letter (registration)
Posted: at 2:38 am
Privately-held Canadian firm Parvus Therapeutics has entered into a license and collaboration agreement
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Novartis licenses nanotech platform in search of diabetes therapy - The Pharma Letter (registration)
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Bellicum Pharmaceuticals (BLCM) Reaches $13.98 After 9.00% Up Move; NANOTECH ENTERTAINMENT (NTEK … – HuronReport
Posted: at 2:38 am
Bellicum Pharmaceuticals (BLCM) Reaches $13.98 After 9.00% Up Move; NANOTECH ENTERTAINMENT (NTEK ... HuronReport NANOTECH ENTERTAINMENT INCORPORATED (OTCMKTS:NTEK) had an increase of 2516.67% in short interest. NTEK's SI was 31,400 shares in April as released by FINRA. Its up 2516.67% from 1,200 shares previously. About 98,901 shares traded. |
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Blind Mystic Baba Vanga Made Scary WW3 Prediction – Unilad – UNILAD
Posted: at 2:38 am
Baba Vanga, the blind Nostradamus of the Balkans, made some troubling predictions about World War Three that have sparked the imagination of conspiracy enthusiasts.
The prophetess, who died aged 85 in 1996, is alleged to have made hundreds of predictions about the future of humanity, with an 85 per cent accuracy rate, from her home in Petrich, Bulgaria.
On closer inspection of her predictions courtesy of some creative internet sorts it seems Baba Vanga also warned of conflict in Syria, nuclear war and the demise of the US president.
Her prophecies take on a new gravitas in the tumultuous global climate of recent months, and the persistent threats of nuclear war batted back and forth between North Korean and American administrations.
Vanga, a woman skilled in eloquent vagaries and nonchalant non-sequiturs, foretold that the world would be ravaged by war and transformed into a wasteland almost entirely devoid of any form of life, reports the Mirror.
According to Vanga this would be kick-started by the Arab Spring in 2010 and ensue after a showdown in Syria wherein Muslims would use chemical warfare against Europeans, eventually resulting in the establishment of a caliphate by 2043 with Rome at the centre.
She cited her own (uncorroborated) second sight when predicting that most people would die of skin cancer from chemical weapons a horrific proposition that some fretful observers have compared to the recent sarin gas attack in Syria.
Troubled politicos also jumped on Vangas prediction that the 45th President would be faced with a crisis that would bring the country down.
Vanga, who is hailed in Russia as having paranormal powers of sight, supposedly prophecised 9/11 when she claimed two steel birds would attack the American brethren.
In 1989, she reportedly warned:
Horror, horror! The American brethren will fall after being attacked by the steel birds. The wolves will be howling in a bush, and innocent blood will be gushing.
Some also believe she predicted global warming when she foresaw cold regions will become warm and volcanoes will awaken.
Moreover, Vangas followers say she predicted the 2004 Boxing Day tsunami, warning a huge wave would descend on a big coast, covering people and towns and [causing] everything to disappear under the water.
In a bizarre leap, some have even suggested she predicted Brexit when she said Europe, as we know it, would cease to exist.
While her predictions may take on a posthumous poignancy and play on the tangible global tensions and public fear, Baba actually got her 1994 World Cup guess wrong, saying two teams beginning with B would stand off.
In fact, Brazil beat Italy 3-2 on penalties. Case closed.
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Blind Mystic Baba Vanga Made Scary WW3 Prediction - Unilad - UNILAD
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North Korea WW3 threat: US nuclear submarine ‘heads to Kim’s … – Daily Star
Posted: at 2:38 am
A US SUBMARINE capable of launching nuclear bombs was filmed heading straight towards North Korea amid growing tensions of World War Three breaking out.
Donald Trump has been urged to strike Kim Jong-uns nuclear supplies before they can reach the US.
He moved devastating Tomahawk missile launchers into firing range of the country just last week and has also sent an armada of warships to the area.
And Trump now appears to be sending a huge submarine to the region.
The US Navy vessel was spotted passing through the Panama Canal an artificial waterway between North and South America yesterday.
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Officials confirmed it was heading into the Pacific Ocean and some believe straight towards North Korea.
Armed soldiers were also pictured pacing across the deck.
A stunned cameraman can be heard saying: Im passing a nuclear submarine, man. Its gigantic.
Kim Jong-un used the annual "Day of the Sun" parade in Pyongyang to make a chilling display of the country's burgeoning nuclear power and military might
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Military vehicles carrying missiles believed to be North Korean KN-08 Intercontinental Ballistic Missiles
Trumps forces arent the only ones concerned with the growing aggression from Kim Jong-Un.
China has admitted a war could break out at any time between the countries and only yesterday positioned their deadly new warship just off North Korea.
Vladimir Putin also moved his Russian forces to the border of the tyrannical state.
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North Korea WW3 threat: US nuclear submarine 'heads to Kim's ... - Daily Star
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Mystic who predicted Trump presidency claims to know date of … – Metro
Posted: at 2:38 am
Horocio Villegas has previously accurately predicted Donald Trumps presidency (Picture:Getty Images)
A mystic claims to know exactly what date WW3will begin and we should probably take note because hes accurately predicted Donald Trumps presidency and the US attack on Syria.
Horocio Villegas, who claims to be the messenger of God, believes nuclear war is just round the corner.
The exact date is predicted to be May 13, 2017 which is the 100th anniversary of the visitation of Our lady of Fatima.
The Catholic clairvoyant, who lives in Texas, US, claims to have predicted Trump would win the US election back in 2015, according to the Daily Star .
He also reportedly predicted the businessman would become the illuminati king who would bring the world into WW3.
And just recently he told the Daily Star: Ihad a dream in which I saw balls of fire falling from the sky and hitting the Earth.
Eerily, one of his predictions has already come true, while the most serious appears to bejust weeks away, he claims.
Villegas is convinced that WW3 will break out on the dayOur Lady another name for the Virgin Mary visited Fatima in Portugalfor the first time.
This issaid to havebeen on May 13, 1917 and was allegedly the day that Our Lady warned people that if Russia did not convert to the Catholic faith, God would use the country to wreak havoc on the world.
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Villegas reportedly told thepaper: The main message that people need to know in order be prepared is that between May 13th and October 13 2017, this war will occur and be over with much devastation, shock and death.
However, he warned that there we will several false-flagevents which will take place between April 13 and May 13, and will see attacks carried out to spark conflicts based on false information.
These will reportedly involve Syria and North Korea.
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Mystic who predicted Trump presidency claims to know date of ... - Metro
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