Daily Archives: March 11, 2017

Huge Step Toward Nanotech-Based Drugs – Controlled Environments Magazine

Posted: March 11, 2017 at 8:25 am

Nanotechnology has become a growing part of medical research in recent years, with scientists feverishly working to see if tiny particles could revolutionize the world of drug delivery.

But many questions remain about how to effectively transport those particles and associated drugs to cells.

In an article published in Scientific Reports, FSU Associate Professor of Biological Science Steven Lenhert takes a step forward in the understanding of nanoparticles and how they can best be used to deliver drugs.

After conducting a series of experiments, Lenhert and his colleagues found that it may be possible to boost the efficacy of medicine entering target cells via a nanoparticle.

We can enhance how cells take them up and make more drugs more potent, Lenhert says.

Initially, Lenhert and his colleagues from the University of Toronto and the Karlsruhe Institute of Technology wanted to see what happened when they encapsulated silicon nanoparticles in liposomes or small spherical sacs of molecules and delivered them to HeLa cells, a standard cancer cell model.

The initial goal was to test the toxicity of silicon-based nanoparticles and get a better understanding of its biological activity.

Silicon is a non-toxic substance and has well-known optical properties that allow their nanostructures to appear fluorescent under an infrared camera, where tissue would be nearly transparent. Scientists believe it has enormous potential as a delivery agent for drugs as well as in medical imaging.

But there are still questions about how silicon behaves at such a small size.

Nanoparticles change properties as they get smaller, so scientists want to understand the biological activity, Lenhert says. For example, how does shape and size affect toxicity?

Scientists found that 10 out of 18 types of the particles, ranging from 1.5 nanometers to 6 nanometers, were significantly more toxic than crude mixtures of the material.

At first, scientists believed this could be a setback, but they then discovered the reason for the toxicity levels. The more toxic fragments also had enhanced cellular uptake.

That information is more valuable long term, Lenhert says, because it means they could potentially alter nanoparticles to enhance the potency of a given therapeutic.

The work also paves the way for researchers to screen libraries of nanoparticles to see how cells react.

This is an essential step toward the discovery of novel nanotechnology based therapeutics, Lenhert says. Theres big potential here for new therapeutics, but we need to be able to test everything first.

Other researchers contributing to the work are Aubrey Kusi-Appiah, Lida Ghazanfari, and Plengchart Prommapan from Florida State University; Melanie Mastronardi, Chenxi Qian, Ken Chen, and Geoffrey Ozin from the University of Toronto; and Christian Kubel from Karlsruhe Institute of Technology in Germany.

This work was funded by the National Institutes of Health.

Source: Florida State University

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Tattooed devotees transform in Thai temple trance – Reuters

Posted: at 8:23 am

By Jorge Silva | WAT BANG PHRA, Thailand

WAT BANG PHRA, Thailand Deep in trances, devotees of a Thai temple charged through gathered crowds on Saturday mimicking the beasts on their tattoos.

Some had their hands curled into tiger claws, some became crocodiles, some were transformed into Hanuman, the monkey god.

The annual tattoo festival at Wat Bang Phra, about 80 km (50 miles) from Bangkok, draws thousands of devotees every year who come to recharge the power of sacred Sak Yant tattoos.

The tattoos are inked by Buddhist monks using sharpened bamboo sticks or long metal needles. Originally etched for warriors needing protection in battle, they are also believed to bring luck and give strength.

But every year, their magic power needs to be restored at the festival, where thousands of devotees pay their respects to the temples master tattooist.

Not everyone goes into a trance. Those who do take on the characteristics of their tattoos. They try to charge toward the temple, but are held back by a wall of temple guards and soldiers.

(Writing by Matthew Tostevin; Editing by Sam Holmes)

The majority of respondents to a new U.S. poll opposed laws barring transgender people from using bathrooms consistent with their gender identities and indicated growing acceptance for gay rights, a nonpartisan research group said on Friday.

CAIRO Archaeologists from Egypt and Germany have found a massive eight-meter statue submerged in ground water in a Cairo slum that they say probably depicts revered Pharaoh Ramses II, who ruled Egypt more than 3,000 years ago.

BERLIN Turkey expressed hopes on Friday for a revival of its tourism industry after security concerns caused a 30 percent drop in foreign visitors and revenues last year.

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Tattooed devotees transform in Thai temple trance - Reuters

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The week’s best mixes: Lorenzo Senni’s trance classics and jackin’ moves from Clone boss Serge – FACT

Posted: at 8:23 am

Each week, FACT trawls through the untamed world of free mixes, radio specials and live blends so you dont have to.

This week, Lorenzo Senni inspires euphoria with a selection of trance build-ups that inspired his recentPersona EP, Sega Bodega makes the Bomfunk MCs cool again and Beat Librae showcases her heady, dub-tinged techno.

Theres also a mix from the UK-based gal-dem zine, jackin house from Clone boss Serge and two hours of neo-classical from Sicario composer Jhann Jhannsson. Dive in.

Lorenzo Senni The Making of Persona

Nobody knows trance like Lorenzo Senni, and here the Warp artist shows us the inner workings of his musical mind with this mix of music that inspired last years Persona EP. Mixing the best bits of everything from commercial EDM and the sounds of Darudes Sandstorm, this mix proves that you can get high without drugs. Just dont expect any drops.

gal-dem Outlook 2017 Mix Series #2

Gal-Dems trilpill reps the UK underground with a mix that packs in everything from garage and grime to dancehall and bassline. Kicking off with Dawn Penns You Dont Love Me (No No No) and folding in tracks by Giggs, General Levy and more, its a party-starting blend that doesnt let up.

Sega Bodega i-DJ Mix

Hot on the heels of his Ess B EP for Crazylegs, rising club artist Sega Bodega lands on the i-D mix series for 40 minutes of edits and originals. As well as tracks from Staycores Dinamarca, Kid Kishore and lo-fi Lisbonite DJ Fatigado, expect VIPs of Halcyon Veil artist Celyn June, Arca and Bomfunk MCs 1999 classic Freestyler. Bonkers, but brilliant.

Beta Librae Truancy Volume 170

Keep this one stored up for when you next require a moment of peaceful immersion, as Kansas-born, New York-based Beta Librae has the perfect recipe. She draws for sparse, fluid house from the deepest depths on a two-part mix that combines her own productions (in the first half) with some of her recent influences, and its heady, soothing stuff perfect for a dazed walk through the city or an late night/early morning session.

Jhann Jhannsson Electronic Explorations 461

Theres still seven months to go until we can hear Jhann Jhannssons Blade Runner 2049 score, but we can at least tide ourselves over with this mix for the Electronic Explorations series. Theres music from fellow soundtrack composers Michael Nyman and Ennio Morricone, but also avant-garde sounds from Morton Feldman, Karlheinz Stockhausen and Greek chamber music trio Mohammad. Perfect for a quiet Sunday morning.

Serge Clone Jack For Daze @ Snar 2015

Clone is 25! The bossman Serge celebrates one of the greatest dance labels in history by sharing his Snar mix from 2015, and its a jackin, smackin spectacular of broken booty shakers and four-to-the-floor filth from DJ Deeon and the like. Wallflowers stay home.

Read next: Blade Runner 2049s Jhann Jhannsson on Orphe and his biggest challenge yet

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Trance and beyond – The Hindu

Posted: at 8:23 am


The Hindu
Trance and beyond
The Hindu
If Tony McGuinness is to be believed, anything can inspire composition. A movie, a book, a parting word or a daydream. I carry a notebook in which I write words and phrases that sound intriguing to me and might become the opening line of a song, says ...

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You be trippin’ out with trance – The Nation

Posted: at 8:23 am


The Nation
You be trippin' out with trance
The Nation
Fans of electronic music will be going wild tonight when the globally renowned trance-music festival brand Transmission touches down in Bangkok at Bitec in Bang Na. Based in Prague, Transmission first came to life in 2006 and was soon one of Europe's ...

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You be trippin' out with trance - The Nation

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First Look: 2017 Giant Trance 1 – Singletrack

Posted: at 8:23 am

As one of the current staples of the Giant lineup, the Trance has been a common sight on trail heads everywheresince it was first rolled outto the global riding market in 2005. Slotting in between the Anthem XC race bike, and the long travel Reign, the Trance was initially launched as one of the firstmodels from Giant to feature the then brand new Maestro suspension design.

With a virtual pivot suspension design that employed two links to suspend the rear swingarm, the Maestro conceptcame about in response to Santa Cruzs VPP and Dave Weagles dw_link. The promise of Maestro was to deliver an efficient pedalling platform without having to resort to clever rear shocks and lockout dials. In the case of the early Trance, thedual-link design delivered 100mm of rear wheel travel in a sturdy package built for all-day trail riding.

Overthe past decade, the Trance has gone on to become one of the most popular models that Giant sells, and one of the most well-recognised full suspension bikes in the world. In that time, the Trance has gone through several redesigns to increase rear wheel travel, which along with improvements to the frame construction andgeometry, hasseenitbecome amore capable machine.

For 2017 though, the Trance has gone through its biggest chance yet. Adopting new standards such as Boost hub spacing and the Trunnion rear shock mount, Giant has undertaken a wholesale redesign of both the Anthem and Trance platforms. A refined version of the Maestro suspension design has been ushered in, along with new geometry and a frame that is purportedly lighter and stiffer overall.

To put those claims to the test, Ive been riding anew Giant Trance 1to see if this is the Taiwanese brandsbesttrail bike yet.

The heart of the new Giant Trance is the reworked Maestro suspension design. Overall, the arrangement remains very similar to the original Maestro architecture, with two struts joining the one-piece swingarm to the front end. Those struts consist of a small link around the bottom bracket and a rocker link that drives the rear shock. Travel sits at 140mm on the rear.

The welded alloyswingarm features a flushBoost 148x12mm thru-axle that requires a 6mm hex key for installation and removal. Post-mount brake tabs will allow the rear calliper to bolt on directly with 160mm rotors, or (as our test bike features) an adapter to work with a larger 180mm rotor.

The lower link extends from the chain stay yoke over the PF92 press-fit bottom bracket shell, where it meets the lower shock eyelet. The beauty of this design is that the link and the shock share a pivot point, which reduces the number of moving parts on the Maestro linkage. All-up including the shock mounts, there are five pivots, all of which rollon sealed cartridge bearings.

The big change over the previous generation Trance is the change to a new Metric shock size that features Trunnion mounting. The Trunnion mount skips the traditional DU bush of a regular shock, and instead allows for the rocker to attach to the shock on the side of the shock body, where it rotates on two cartridge bearings instead. The result is less stiction for a smoother starting stroke and thusly, a more supple suspension feel. The other advantage that the Metric-sized shock provides is a smaller package for the same given stroke, so theres moreflexibility for the designers when engineering the front triangle.

The Trance 1 is the top-spec model in the alloy range, and so it receives a tidy suspension packagefrom Fox. Theres a Performance Elite Fox Float rear shock,which comes complete with an EVOL air can and 3-way adjustable compression damping. To complement the 140mm of rear wheel travel, Giant has specd a Fox 34 Float fork up front with 150mm of travel.

Cockpit components come from the Giant stable in the form of a Contact SL Trail handlebar that measures 750mm wide, and a Contact stem that runs at a 60mm length for the Extra Small, Small, and Mediumframe sizes, and 70mm for the Large and Extra Large frame sizes. Interestingly, this is the same bar and stem setup as found on the shorter-travel Anthem XC bike. My plan is to trythe Trance with a slightly wider bar and a shorter stem to see howits handling plays with a more fashionable cockpit setup.

Braking on the Trance 1 is handled by Shimano Deore XT stoppers, with 180mm Ice Tech rotors front and rear. Note the KaBolt setup on the Fox 34 fork, which Giant has specd instead of the standard QR15 quick-release lever.

Shimano has also been called on for the drivetrain on the Trance 1, with a slick 111 setup delivering a wide range of gears thanks to the larger11-46t cassette. The 32t chainring uses Shimanos new narrow-wide tooth profile, and the Shadow Plus rear derailleuruses a direct-mount hanger to keep shifting crisp.

Since first building up the Trance 1, Ive made a couple of changes to the spec for riding our local trails. The Schwalbe tyres have been pulled off to make way for more aggressive (and wider) Maxxis Minion tyres. Theres a 2.4in DHR II on the rear, which uses the 3C MaxxTerra rubber compound and EXO reinforced sidewalls.

To match the rear Minion DHR II, theres a Minion DHF on the front that measures 2.5in wide. Both Minions are the new Wide Trail (WT) size, which is ideally suited to the newer crop of rims that are running broaderinternal rim widths.

On the note of the wheelset, its a good-looking carbon fibre numbers from Giant. Called the TRX 1, the wheelset features28 straight-pull Sapim Laser/Race spokes per wheel, and theyre lacedto lovely CNC machined hub shells. The rims are tubeless ready, and blue rim tape is included in the box with the bike from new. Setting tyres up tubeless is easy as pie, and the seal is very secure between tyre and rim.

Before taking the Trance 1 off road, I stripped the wheels down and put them on the scales because Im a nerd like that. For the pair, the complete wheelset without tape and valves weighs in at just 1649 grams, which is pretty svelte for a carbon trail wheelset, and a few grams lighter than claimed. Nice!

One other change Ive made to the stock spec is the addition of a Wolftooth ReMoteto activate the Giant Contact SL Switch-R dropper post. With a CNC machined construction and a broad, textured paddle, the Wolftooth ReMote is a welcome addition to the Trance 1s ergonomics, and is available witha standard bar clamp, or in versions that are compatible with either Shimano or SRAM brake levers.

The Trance 1 frame itself is constructed from Giants own hydroformed alloy blend called ALUXX-SL. The tubes all receive heavy shaping to create some stunning lines that rival that of the carbon versions. The welded areas are broad and chunky, as isthe stout tapered head tube and the 92mm wide press-fit bottom bracket.

All cables route internally through the front triangle,with the rear brake hose and derailleur cable exiting at the base of the downtube. These then run externally on the rear swingarm, while the dropper post line runs internally all the way through and up into the seat tube.

With the new carbon fibre rocker link, the lines on the back end of the Trance have been massaged to be even cleaner, with smooth lines running from front to back. Its certainly a good looking piece of kit, and its a great example of therecent advances in alloy construction techniques. Interestingly, you can also get a Trance Advanced 2 for nearlythe same price as this bike here, so consumers have a choice of whether they want the better build kit with the alloy frame, or the carbon frame with a cheaper build kit.

Over the coming months, Ill continue to put the Trance 1 through a variety of riding conditions and trail types to see where this 140mm travel trail bike really shines. Well also be using the Trance to test out multiple components, including the Maxxis Minion tyres and a few other items that youll read about in the near future.

In the meantime, you can head to Giant Bicycles website for more information about the 2017 range.

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Aurora Oil & Gas’ Successor Australis Quadruples TMS Acreage – Oil and Gas Investor (registration)

Posted: at 8:20 am


Oil and Gas Investor (registration)
Aurora Oil & Gas' Successor Australis Quadruples TMS Acreage
Oil and Gas Investor (registration)
The Tuscaloosa Marine Shale (TMS) has been in the industry's no man's land the past couple of years, but an Australian company led by the founder of Aurora Oil & Gas aims to change that. Australis Oil & Gas Ltd. agreed to buy 62,000 operated net acres ...

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TMS Installs 2017 Board Members – Newswise (press release)

Posted: at 8:20 am

Newswise March 10, 2017 Pittsburgh, PA (USA) The Minerals, Metals & Materials Society (TMS) installed six new officers during the TMS 2017 Annual Meeting & Exhibition, held February 26March 2, 2017 in San Diego, California. The following individuals have joined the TMS Board of Directors:

Kevin J. Hemker, 2017 Vice President

Kevin J. Hemker is Alonzo G. Decker Chair and Professor of Mechanical Engineering at Johns Hopkins University. A professional member since 1991, Hemker has served two terms on the TMS Board of Directors as Public & Governmental Affairs (P&GA) Director from 2008 to 2013. He has also contributed as a member of the Titanium, Strategic Planning, and P&GA committees. Currently the Alonzo G. Decker Chair and Professor of Mechanical Engineering at Johns Hopkins University, Hemker also holds joint appointments in the Departments of Materials Science and Engineering and Earth & Planetary Sciences. In 2014, he was elected as a TMS Fellow. Hemker earned his B.S. in metallurgy from the University of Cincinnati, and his M.S. and Ph.D. in materials science and engineering from Stanford University.

Hemker will serve a three-year term with TMSas vice president in 2017, president in 2018, and past president in 2019.

Michele V. Manuel, Content Development & Dissemination Director/Chair

Michele V. Manuel is a professor in the Department of Materials Science and Engineering at the University of Florida. Manuel received her Ph.D. in materials science and engineering at Northwestern University and her B.S. in materials science and engineering at the University of Florida. A TMS member since 2001, she has served on a number of technical and administrative committees for the society, most notably as the vice chair of the Content Development & Dissemination Committee, as editor of Magnesium Technology 2015, and as a JOM advisor. Manuel is the recipient of a 2009 TMS Light Metals Division (LMD) Young Leaders Professional Development Award, a 2014 Early Career Faculty Fellow Award, and the 2014 Young Leaders TMS/Japan Institute of Metals (JIM) International Scholar Awardall supported by the TMS Foundation.

Chester J. Van Tyne, Professional Development Director/Chair

Chester J. Van Tyne is the Forging Industry Education and Research Foundation (FIERF) Professor in the George S. Ansell Department of Metallurgical and Materials Engineering at the Colorado School of Mines. He has served as Associate Department Head since 2011 and teaches courses in statistical process control and design experiments, as well as forging and forming. A member of TMS since 1980, Van Tyne has been an active member of the Education and Professional Registration committees, and has served as chair of the Accreditation Committee. He has also been involved with the ABET accreditation process since 1991 as a program evaluator, team chair, and member of the Engineering Accreditation Commission. Van Tyne earned both his undergraduate and graduate degrees from Lehigh University. In 1984, he earned his professional engineer (PE) license in Pennsylvania.

John A. Howarter, Public & Governmental Affairs Director/Chair

John A. Howarter is an assistant professor in materials engineering at Purdue University, with a joint appointment in environmental and ecological engineering. A TMS member since 2002, Howarter has served as vice chair of the Public & Governmental Affairs (P&GA) Committee and is a regular contributor to the technical programming for both the TMS annual meeting and Materials Science & Technology (MS&T) conference. He was also a member of the organizing committee for the REWAS 2016 symposium held in conjunction with the TMS 2016 Annual Meeting & Exhibition. In 2015, Howarter received a TMS Extraction & Processing Division (EPD) Young Leaders Professional Development Award. Since 2014, Howarter has served as the chapter advisor for the Purdue University Material Advantage student organization. He earned his B.S. from The Ohio State University and his Ph.D. from Purdue, both in materials engineering.

Cynthia K. Belt, Extraction & Processing Division Chair

Cynthia K. Belt is an Energy Management Consultant at Metals Energy Management LLC. Prior to working as a consultant, she developed and managed energy programs at Kaiser Aluminum, Superior Industries, and Aleris International. Belt is the former chair of the TMS Energy Committee, has been an active member of the Recycling & Environmental Technologies and Materials & Society committees, and served as a TMS representative to the Carbon Management Technology Conference Committee. She has served as vice chair of the Extraction & Processing Division (EPD) Council and has also served on both the EPD and LMD Councils in her more than ten years as a TMS member. In 2012, she received the LMD Distinguished Service Award, and then earned the 2013 Energy Best Paper Award, along with her co-authors, for "Energy Opportunities in the Aluminum Processing Industry," published in Energy Technology 2012. Belt earned her B.S. in mechanical engineering from Ohio Northern University and is a trained Six Sigma Black Belt.

Raymundo Arryave, Functional Materials Division Chair

Raymundo Arryave is an associate professor in the Department of Materials Science and Engineering at Texas A&M University. A TMS member for more than ten years, Arryave has served as chair of the TMS Alloy Phases Committee, vice chair of the Functional Materials Division (FMD) Council, and as a member of many other technical and administrative committees, including the Integrated Computational Materials Engineering and Professional Development committees. In addition to chairing symposia at TMS annual meetings and MS&T conferences, he co-organized the 2015 TMS Middle EastMediterranean Materials Congress on Energy and Infrastructure Systems. He received the Electronic, Magnetic & Photonic Materials Division (EMPMD; now Functional Materials Division) Distinguished Service Award in 2014 and the EMPMD Young Leaders Professional Development Award in 2006. Arryave received his B.S. in mechanical and electrical engineering from the Instituto Tecnolgico y de Estudios Superiores de Monterrey in Mexico and both his M.S. in materials science and engineering and his Ph.D. in materials science from the Massachusetts Institute of Technology.

ABOUT TMS

The Minerals, Metals & Materials Society (TMS) is a member-driven international professional society dedicated to fostering the exchange of learning and ideas across the entire range of minerals, metals, and materials science and engineering, from minerals processing and primary metals production, to basic research and the advanced applications of materials. For more information on TMS, visit http://www.tms.org.

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How to ensure future brain technologies will help and not harm society – USAPP American Politics and Policy (blog)

Posted: at 8:19 am

Thomas Edison, one of the great minds of the second industrial revolution, once said that the chief function of the body is to carry the brain around. Understanding the human brain how it works, and how it is afflicted by diseases and disorders is an important frontier in science and society today.

Advances in neuroscience and technology increasingly impact intellectual wellbeing, education, business, and social norms. Recent findings confirm the plasticity of the brain over the individuals life. Imaging technologies and brain stimulation technologies are opening up totally new approaches in treating disease and potentially augmenting cognitive capacity. Unravelling the brains many secrets will have profound societal implications that require a closer contract between science and society.

Convergence across physical science, engineering, biological science, social science and humanities has boosted innovation in brain science and technological innovation. It offers large potential for a systems biology approach to unify heterogeneous data from omics tools, imaging technologies such as fMRI, and behavioural science.

Citizen science the convergence between science and society already proved successful in EyeWire where people competed to map the 1,000-neuron connectome of the mouse retina. Also, the use of nanoparticles as coating of implanted abiotic devices offers great potential to improve the immunologic acceptance of invasive diagnostics. Brain-inspired neuromorphic engineering aims to develop novel computer systems with brain-like characteristics, including low energy consumption, adequate fault tolerance, self-learning capabilities, and some sort of intelligence. Here, the convergence of nanotechnology with neuroscience could help building neuro-inspired computer chips; brain-machine interfaces and robots with artificial intelligence systems.

Future opportunities for cognitive enhancement for improved attentiveness, memory, decision making, and control through, for example, non-invasive brain stimulation and neural implants have raised, and shall continue to raise, profound ethical, legal, and social questions. What is societally acceptable and desirable, both now and in the future?

At a recent OECD workshop, we identified five possible systemic changes that could help speed up neurotechnology developments to meet pressing health challenges and societal needs.

There is growing interest in discussing and unpacking the ethical and societal aspects of brain science as the technologies and applications are developed. Much can be learned from other experiences in disruptive innovation. The international Human Genome Project (1990-2003), for example, was one of the earlier large-scale initiatives in which social scientists worked in parallel with the natural sciences in order to consider the ethical, legal and social issues (ELSI) of their work.

The deliberation of ELSI and Responsible Research and Innovation (RRI) in nanotechnologies is another example of how societies, in some jurisdictions, have approached R&D activities, and the role of the public in shaping, or at least informing, their trajectory. RRI knits together activities that previously seemed sporadic. According to Jack Stilgoe, Senior Lecturer in the Department of Science and Technology Studies, University College London, the aim of responsible innovation is to connect the practice of research and innovation in the present to the futures that it promises.

Frameworks, such as ELSI and RRI should more actively engage patients and patient organisations early in the development cycle, and in a meaningful way. This could be achieved through continuous public platforms and policy discussion instead of traditional one-off public engagement and the deliberation of scientific advances and ELSI through culture and art.

Research funders public agencies, private investors, foundations, as well as universities themselves are particularly well positioned to shape trajectories of technology and society. Through their funding power, they have unique capacity to help place scientific work within social, ethical, and regulatory contexts.

It is an opportune time for funders to: 1) strengthen the array of approaches and mechanisms for building a robust and meaningful neurotechnology landscape that meaningfully engages human values and is informed by it; 2) discuss options to foster open and responsible innovation; and 3) better understand the opportunities and challenges for building joint initiatives in research and product development.

Society and industry would benefit from earlier, and more inclusive, discussions about the ethical, legal and social implications of how neurotechnologies are being developed and their entry onto the market. For example, the impact of neuromodulatory devices that promise to enhance cognition, alter mood, or improve physical performance on human dignity, privacy, and equitable access could be considered earlier in the research and development process.

Given the significant investment risks and high failure rates of clinical trials in central nervous systems disorders, companies could adopt more open innovation approaches in which public and private stakeholders actively collaborate, share assets including intellectual property, and invest together.

Popular media is full of colourful brain images used to illustrate stories about neuroscience. Unproven health claims, including those which give rise to so-called neuro-hype and neuro-myths. Misinformation is a strong possibility where scientific work potentially carries major social implications (for example, work on mental illness, competency, intelligence, etc).

It has the potential to result in public mistrust and to undermine the formation of markets. There is a need for evidence-based policies and guidelines to help the responsible development and use of neurotechnology in medical practice and in over-the-counter products. Policymakers and regulators could lead the development of a clear path to translate neurotechnology discoveries into human health advantages that are commercially viable and sustainable.

Policymakers should discuss the socio-economic questions raised by neurotechnology. Rising disparities in access to often high-priced medical innovation require tailored solutions for poorer countries. The development of public-private partnerships and simplification of technology help access to innovation in resource-limited countries.

In addition to helping people with neurological and psychiatric disorders, the biggest cause of disability worldwide, neurotechnologies will shape every aspect of society in the future. A roadmap for guiding responsible research and innovation in neurotechnology may be transformative.

Notes:

P. Murali Doraiswamy Leading expert in brain and behavioural sciences, health innovation and mobile medical technologies. Professor of Psychiatry and Medicine, Duke University Health System. Member of corporate and non-profit boards. Adviser to several health and technology businesses.

Hermann GardenOrganisation for Economic Co-operation and Development, Working Party on Biotechnology, Nanotechnology and Converging Technologies

David WinickoffOrganisation for Economic Co-operation and Development, Working Party on Biotechnology, Nanotechnology and Converging Technologies

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How to ensure future brain technologies will help and not harm society - USAPP American Politics and Policy (blog)

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Stryker’s Spine division to exhibit key technologies at AAOS 2017 – OrthoSpineNews

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ALLENDALE, N.J.(BUSINESS WIRE)Strykers Spine division today announced that it will demonstrate its Aero-C Cervical Stability System (Aero-C) and Xia 4.5 Cortical Trajectory implants and instruments (Xia CT) at the American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting, March 1518, 2017, in San Diego (booth No. 3133).

Aero-C, the only straight forward anterior cervical discectomy and fusion (ACDF) device that offers uniform compression across the interbody space, will be displayed at AAOS 2017, highlighting its full commercial launch. Using Aerofoil Compression Technology, Aero-C is designed to pull the vertebral bodies toward the implant as it is inserted, creating compressive forces at the implant-to-endplate interface.1 Aerofoil Compression Technology is also available for lateral and anterior lumbar interbody fusion procedures (LLIF and ALIF). Since the initial introduction to the market, over 600 cases have been completed.

Also to be demonstrated at AAOS is Xia CT, which includes implants and instruments used in less invasive LITe LIF posterior lumbar interbody fusion procedures for patients with degenerative disc disease, spondylolisthesis, and trauma. The cortical trajectory procedure facilitates a smaller midline incision to help achieve decompression, fixation, and fusion.2 It also is intended to be more muscle sparing than standard open procedures that require lateral dissection, and its reduced incision may allow for more efficient exposure and closure time.2 The launch of the Xia CT system occurred in 2016, with 575 cases completed to date.

Since their introduction last year, Aero-C and Xia CT have been well received by our surgeon customers and have achieved rapid adoption in the marketplace, said Bradley Paddock, President of Strykers Spine division. These unique products reflect our strong commitment to advancing spine health and helping to enhance outcomes for patients by providing physicians with innovative and differentiated technology.

Aero-C and Xia CT offer advancements that highlight the Spine divisions leadership in pioneering innovative technologies for traditional and minimally invasive surgical techniques. The company offers one of the most comprehensive and diverse product portfolios for the treatment of degenerative and complex spinal disorders. Its suite of leading-edge products includes implants, instruments, and biologics for the cervical, thoracic, and lumbar spine.

About Stryker

Stryker is one of the worlds leading medical technology companies and, together with our customers, we are driven to make healthcare better. The Company offers a diverse array of innovative products and services in Orthopaedics, Medical and Surgical, and Neurotechnology and Spine that help improve patient and hospital outcomes. Stryker is active in over 100 countries around the world. Please contact us for more information atwww.stryker.com.

References

Indications for Use

The AERO-C Cervical Cage is indicated for use in cervical interbody fusion procedures in skeletally mature patients with degenerative disc disease (DDD) at one level from the C2-C3 disc to the C7-T1 disc. The AERO-C Cervical Cage System is to be used with autogenous bone graft and/or allogenic bone graft comprised of cancellous and/or corticocancellous bone graft, and is to be implanted via an open, anterior approach.

The Xia CT implants and instruments are intended for anterior/anterolateral and posterior, non-cervical pedicle and non-pedicle fixation for the following indications: Degenerative Disc Disease (as defined by back pain of discogenic origin with degeneration of the disc confirmed by patient history and radiographic studies); spondylolisthesis; trauma (i.e. fracture or dislocation); spinal stenosis; curvatures (i.e., scoliosis, kyphosis, and/or lordosis); tumor; pseudarthrosis; failed previous fusion.

Content ID: CVAER-PR-2_13458

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Stryker's Spine division to exhibit key technologies at AAOS 2017 - OrthoSpineNews

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