Daily Archives: March 6, 2017

TMS to host fashion showcase – Troy Daily News

Posted: March 6, 2017 at 3:23 pm

TROY Troy Main Street will treat its Style Showcase Fashion Show guests to an evening of 2017 spring fashions from downtown Troy boutiques and dcor shops.

The event, being held on Friday, March 31, at the Troy-Hayner Cultural Center, features home dcor displays from 6-8 p.m. and a runway fashion show from 7-9 p.m. Downtown restaurants and venues are offering discounts for dinner the night of the show (with ticket), and ReU Juicery and Olive Oasis will be sampling healthy, fresh spring flavors at the event.

This is the second year for this event in downtown Troy. We are bringing most of our boutiques and home dcor merchants together, along with our hair salons, for a complete evening of styles and inspiration, said Shelly Calvert, marketing and events coordinator for Troy Main Street. We will be talking about how to create fresh spring looks that are uniquely you, including advice from event sponsor Christy Shell of Zeal Coaching.

Our guests can expect a variety of boutique clothing fashions and home dcor styles that will fit any age and style preference, Calvert added. Thats the fun of it everyone will be in one location, so people will get a sneak peek of whats for sale in our downtown stores. The hair salons will style the models hair, including up-dos, for spring looks, prom and wedding preview.

Tickets, which are $10 each, are required for the runway fashion show and restaurant discounts. Ticket holders will receive a swag bag full of coupons. No ticket is necessary to view the home dcor tables at the Troy-Hayner.

Tickets are limited to the first 130 guests, and go on sale March 10 at participating downtown Troy stores. A portion of the proceeds from each ticket will benefit Reading For Change.

Troy Main Street is a non-profit downtown organization whose mission is to Strengthen the heart of our community.

For more information about the Troy Main Street Style Showcase Fashion Show, go to troymainstreet.org, or call the office at (937) 339-5455.

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TMS to host fashion showcase - Troy Daily News

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How ‘brain wearables’ can address 21st century needs – IoT Tech News

Posted: at 3:22 pm

The human brain is the mostcomplex system in the known universe. It is imbued with enormous potential that we have yet to fully understand or to harness. But were making progress, for many good reasons.

By studying how the human brain functions and how it responds to stimuli, we can potentially train our minds for optimal performance and, perhaps, overcome physical disabilities or detect neurological abnormalities for treatment. We stand now on the cusp of what has been called The Fourth Industrial Revolution, a revolution that is growing out of the integration of the physical, digital and biological realms. The ability to directly connect electronic devices to the human organism in order to affect physical objects around us has the potential to drive change forward at an exponentially increasing pace. Our understanding of our limitations will be shattered, and new vistas will open up, as we explore the possibilities that arise when we bring minds, machines, and the material world together.

Put simply, we stand to reap enormous benefits if we can enlighten ourselves as to why and how we think and feel - to improve how we interact with and experience the world around us.

Today, innumerable such efforts proceed in specialised laboratories around the world, with a rather limited number of research subjects. But everyones brain is unique and changing in unique ways. The term neuroplasticity means that our brains change shape and function based on personal biological factors as well as our individual experiences in life. So were likely to gain commensurately greater insights from a broader participation in such studies.

And thats where brain wearables come into the picture.

A market for brain wearables has promised to put neurotechnology into the hands of ordinary people. This is important because of the uniqueness of every brain; the greater the sample, the more robust the insights it yields.

Today these devices fall into two main categories. One uses electroencephalograms (EEGs) essentially, surface brain wave activity in a non-invasive, read-only mode, which can provide data on the wearers mental and emotional state. The other basic approach relies on transcranial direct current stimulation (TDCS), which sends electrical signals to the brain for neuro-priming, which is intended to promote hyper-learning.

I work in the EEG-related field of brain wearables, which offer a means to further our understanding of the human brain in a useful form factor and at a reasonable price point.

We are using brain wearables to conduct longitudinal studies over time in more than 120 countries to discern how different stimuli and situations affect different brains, helping us understand, for instance, how different people react to handling stress or how we can assist them in achieving optimal performance.

In practical terms, understanding and encouraging high performance is one focus of our work, which would have obvious benefits for athletes, soldiers, professionals, artists nearly everyone, really. And the broadest possible application would be to gain a better understanding of how various stimuli and our own, often very individual responses affect our thoughts and feelings. The end result could be to inform an improved self-awareness and a better understanding of ourselves to mitigate irrational or unproductive behaviour.

Ultimately, those of us in the brain wearables field would like to make progress on the early detection of neurological issues and overall brain health.

One in three people, of the more than seven billion on Earth, are affected by brain-related illnesses, including depression, anxiety, dementia, autism, attention-deficit disorder (ADD), attention-deficit hyperactivity disorder (ADHD), stroke or trauma. Apart from widespread human suffering, these disorders are estimated to cost the global economy some $2 trillion per year. In the U.S., specifically, an aging population has the potential for extended lives, for which quality-of-life will require healthy brains.

Brain health is also considered a key factor in many other bioinformatics advances. I think of it as a quintessential 21st century issue.

Though Im positively buoyant about the known and potential benefits of brain wearables, it is also our duty to be vigilant about the potential risks.

Data privacy and security are perennial concerns for everyone. These concerns are heightened when personal health-related matters are at stake. The Health Insurance Portability and Accountability Act of 1996 (HIPAA) provides legal protections and it is up to technologists to ensure that data privacy and security protections are state of the art.

Currently we are careful to apply significant effort and care to user consent issues for participation in studies we conduct. The critical issue, in my view, is preserving individual choice and the personal integrity of every individual.

I have few real concerns at this stage, because wearables are just that; you can put them on or take them off and anonymising data in studies is standard practice. But if brain wearables or related technologies were to become embedded in the human body, theres an obvious risk of abuse. Today, arguably, our thoughts and feelings are our own, but we know that chemical reactions govern these and thus they could be manipulated, leading to a loss of individuality.

Our approach is the opposite of a dystopian use of brain monitoring technology. Our philosophy is to democratize technology and make tools such as brain wearables more affordable, easier to use. Our technology platform is based on open access software (e.g., extensible APIs), aimed at both broad uptake (if the market finds them useful), and the broadest possible base of innovation to benefit all. We want to avoid creating another aspect of a digital divide, with brain wearables available only to a few who can afford them. We believe this approach is in step with societys shared values.

We work with partners across many domains and more than 120 countries, an open acknowledgement that we dont have all the answers. The direction that brain wearables take is not up to us as pioneers in the field. Its an open conversation. We simply want to position the technology and raise awareness for the greatest breadth and depth of potential contributions to the field. The more participants in brain wearable trials the more we learn about the behavior of the human brain and ways in which its health and optimal use can be encouraged.

Widespread adoption is the crux of our success. A broad and diverse dialogue on the issues of brain health and technology will enable the enhancement of healthy brains and detect signs of cognitive decline and disorders.

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How 'brain wearables' can address 21st century needs - IoT Tech News

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Vertex, Concert orchestrate $250M phase 2 CF drug deal – FierceBiotech

Posted: at 3:20 pm

Vertex could pay out as much as $250 million to gain full access to Concert Pharmaceuticals midstage cystic fibrosis (CF) candidate CTP-656, a tweaked version of its own Kalydeco, as it eyes combo uses that target the underlying causes of the fataldisease while taking over a potential competitor product.

The deal sees Vertex, which is looking to build up its marketed CF franchise, pay $160 million in cash with $90 million in biobucks also lined up for the future.

Thepharma gets CTP-656 for its moneyan investigational cystic fibrosis transmembrane conductance regulator (CFTR) potentiator that the company hopes it can use as part of a once-daily combo of CFTR modulators that treat the underlying cause of CF.

This will dovetail with its CF meds: Kalydeco (ivacaftor) and more recently its combo therapy Orkambi (lumacaftor/ivacaftor).

Kalydeco is suitable for CF patients with the Gly551Asp mutation in the CFTR generepresenting just 4% to 5% of the total patient populationbut adding lumacaftor means that it can be prescribed for about 45% of patients. The second ingredient targets those carrying two copies of the much more common F508del mutation.

CTP-656 was in fact developed by Concert through the use of its deuterium chemistry to modify ivacaftor as it looked to make a better version of the drug. The big idea at Concert is taking approved or previously studied drugs and reformulating them with deuterium to boost their safety, tolerability and efficacy, creating new, and patentable, products in the process.

Back in 2015, the biotech posted data showing its treatment lasted longer than Vertex med in a small, early-stage trial. Clearly, Vertex wants to get its hands fully on this boosted version of its drug.

With Vertexs clinical and commercial expertise in CF, this agreement provides the optimal pathway to rapidly advance the development of CTP-656 for the benefit of cystic fibrosis patients, said Roger Tung, president and CEO of Concert Pharmaceuticals.

The financial strength provided to Concert by this agreement will allow us to advance [autoimmune med] CTP-543 into pivotal testing and broaden our proprietary development pipeline.

Concert is currently conducting a phase 2 study of CTP-656 in people with CF who have gating mutations. As part of the agreement, Vertex gains all rights to Concerts other CF research and preclinical programs.

Analysts at Leerink said they saw the deal as a positive for Vertex, saying in a note: "First, most obviously it removes a potential competitor, and, more importantly, a potential combination partner for other entrants who may possess a CFTR corrector. It signals Vertex's willingness to enhance and improve its existing franchise and portfolio in CF, rather than fret over "not-invented-here" considerations.

"Second, it offers a potentially improved profile for futuremulti-drug CF combinations. Third, it can extend the duration of Vertex's CF combinations even longer, given likely composition-of-matter exclusivity for Kalydeco of 2027 in the U.S. and 2025 in Europe, compared to 2032-plusin the U.S. and Europe for CTP-656.

"CTP-656 was one of numerous CF competitors in early clinical trials that have been advanced in parallel with Vertexs race to concoct a triple-therapy regimen for the majority of CF patients, and todays news signals, in our view, the willingness of Vertex to defend its dominant and valuable position in the market category."

Concert rocketedup more than 77%on the news while Vertex edged down 0.5%.

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Vertex, Concert orchestrate $250M phase 2 CF drug deal - FierceBiotech

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Revenue Approximations Analysis: New York Community Bancorp, Inc. (NYCB), CF Industries Holdings, Inc. (CF) – StockNewsJournal

Posted: at 3:20 pm

Revenue Approximations Analysis: New York Community Bancorp, Inc. (NYCB), CF Industries Holdings, Inc. (CF)
StockNewsJournal
CF Industries Holdings, Inc. (NYSE:CF), maintained return on investment for the last twelve months at -1.41, higher than what Reuters data shows regarding industry's average. The average of this ratio is 2.86 for the industry and sector's best figure ...

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Revenue Approximations Analysis: New York Community Bancorp, Inc. (NYCB), CF Industries Holdings, Inc. (CF) - StockNewsJournal

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Mr. Brewster Raises $33500 for CF Research – HamletHub

Posted: at 3:20 pm

The Mr. Brewster Pageant was held last Friday and it was a tremendous success. The event is host by the S.A.L.T.Y Hands Club whose mission is toraise money and awareness for Cystic Fibrosis research. S.A.L.T.Y stands for Save A Life of Todays Youth. Individuals with CF also often exhibit a salty condition on their skin. For more information about Cystic Fibrosis or help support the efforts to find a cure please visit the Cystic Fibrosis Foundation webpage:https://www.cff.org.

For the Mr. Brewster title, contestant collect donations for the Cystic Fibrosis Foundation. They earn points for the money they collect. The contestants also receive points from the pageant event. The pageant includes several different activities to test the talents and the ability of contestants to think on their feet. Faculty judges included:, Peter Goumas, Michael Castaldo, Terry Schumacher, and Nicole Vitale Sweeney. The MC for the event was Matt Cunningham. Donna Lieval is the adviser of S.A.L.T.Y Hands Club and Mrs. Ann Marie Chalmers spearheads the activities for the Mr. Brewster event.

Brendan Feehan was crowned Mr. Brewster this year, but everyone involved did a wonderful job with the efforts. The other candidates that participated in the pageant event wereJack Guida, Sean Nevin, Connor Dignan, Sean Kelly, Nathan Beal, Tim Catalano, Ryan Wynne, Austin Kaelin, Ryan Hecht, Chris Zavras, Anthony Aiello and Spence Bera. Other individuals also collected money towards the effort but did not compete in the pageant. $33,500 represents an amazing effort from our group of students and will provide significant assistance toward CF Research.

BHS student Amber Krisch wrote a piece for the Hamlet Hub highlighting the the event. The article can be foundhere.

A complete video of the Mr. Brewster Pageant can be found here.

Hereis a video highlighting Brian McPartland and his activities at Duke University. Brian has CF and graduated from BHS and 2011.

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Mr. Brewster Raises $33500 for CF Research - HamletHub

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CF Industries Holdings, Inc. (CF): How Do the Technicals Stack Up? – The USA Commerce

Posted: at 3:20 pm


The USA Commerce
CF Industries Holdings, Inc. (CF): How Do the Technicals Stack Up?
The USA Commerce
We have gathered the technical data on CF Industries Holdings, Inc. (CF), and see some interesting trends in the stock's behavior of late. Every professional at some point comes to respect the actual behavior of a stock as the true arbiter of right and ...

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CF Industries Holdings, Inc. (CF): How Do the Technicals Stack Up? - The USA Commerce

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Ugh: Americans Still Think Less of People Without Kids – Glamour

Posted: at 3:19 pm

PHOTO: Courtesy Everett Collection

The proportion of people who don't have children has gone way up over the past few years. The birth rate for women in their twenties dropped by 15 percent from 2007 to 2012, and nearly half of women ages 15-44 had no kids in 2014. There's even a new word for the decisionopting to be "childfree"as a less pitiable-sounding alternative to"childless." Celebrities from Oprah Winfrey to Jennifer Aniston have spoken out about the fact that we don't need kids to feel complete.

But that message hasn't reached everyone. A study published in Sex Roles has found that even Millennials, a third of whom plan to remain childfree themselves, don't just consider people without kids less fulfilledthey actually get angry when they hear about them.

Indiana University-Purdue University Indianapolis, Indianapolis professor Leslie Ashburn-Nardo gave 197 college students an excerpt about someone named James or Jennifer who had either two kids or none. Then, she asked them to rate how happy the character was with their marriage, their children or lack thereof, and life overall. Participants were also asked how this person made them feel.

People considered the childfree characters less satisfied than those with two kids, and they felt "significantly greater moral outrage" toward them than toward parents. And although many women in particular have felt pressured to start families due to gender roles, negative feelings were directed equally toward Jennifer and James.

These findings confirm what a lot of childfree peopleand even people like Adele who have had kids but don't want morehave been saying all along: The stigma against them is real. 69 percent of Millennials believe this isn't a problem anymore, but the data suggest otherwise. There's clearly still a lot of work to be done to change society's attitudes about children and who does and doesn't have them.

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Ugh: Americans Still Think Less of People Without Kids - Glamour

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Misguided political correctness is problem – Walla Walla Union-Bulletin

Posted: at 3:19 pm

It is high time we stop with the delusion regarding the true meaning of political correctness. The ugly truth is that it is nothing more than Marxist mind control.

A good case in point is the incorrect use of words like immigrant, undocumented migrant, etc. In a country founded on the rule of law, aliens that infiltrate our borders illegally are law breakers, not immigrants!

Acceptable immigration is based on legal entry into a country, utilizing a realistic quota that insures assimilation, in order to guarantee that newcomers embrace American values, respect our culture and the heritage that belongs to our countrymen.

We are witnessing a major threat from a ramped, uncontrolled change in demographics that is a serious threat to our sovereignty.

Many of these same groups, while taking advantage of our misguided government handouts, show their gratitude by demanding we conform to an unacceptable foreign culture at the demise of our value system, and yes, even to change our judicial system to a maniacal system, the likes of Sharia Law.

What ever happened to good old Yankee common sense? As of late we have been plagued with totally irresponsible leaders who have failed miserably by not enforcing the existing immigration laws. As a result, we are now faced with a difficult, controversial challenge in how best to devise an equitable solution.

The one thing that has become perfectly clear would indicate that uncontrolled immigration is a threat to the country and a way of life that generations before us have been willing to die for.

Yes, we are a benevolent country that embraces immigration. However, unenforced immigration without quotas and conditions that require respect of our laws and value system including assimilation, cannot be allowed to continue unabated in its present form.

Wake up America! It looks as though Nikita Khrushchev was correct after all when he said, America will self-destruct from within!

Today, we are witnessing the demise of a civil America assisted by these same arrogant foreign trespassers involved in anti-American demonstrations, embedded with uncontrolled hooligans committing acts of violence and the destruction of private property.

All this in the name of PCs misguided tolerance of irresponsible free speech!

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Misguided political correctness is problem - Walla Walla Union-Bulletin

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Why ‘rage is not a policy’ – Washington Times

Posted: at 3:19 pm

ANALYSIS/OPINION:

POLITICAL CORRECTNESS AND THE DESTRUCTION OF SOCIAL ORDER: CHRONICLING THE RISE OF THE PRISTINE SELF

By Howard S. Schwartz

Palgrave McMillan, $99.99, 199 pages

We usually think of the culture wars as being a competition between the broad groups we currently call progressives, and conservatives, each of which has a general concept of a just society. While they intensely disagree, each group understands the others goals. Historically, each has tried to win people over; remember the old 1960s demonstrators approach, are you aware of the students ten demands? May I give you a copy? Lately, though, we see rebelliousness without goals, and the careful honing of the sensibilities to a level of refinement that can perceive the remotest connection to an offense, real, intentional, or not. We, left and right alike, drape a blanket called political correctness over it all, and sit, baffled, as though we tuned in late and missed most of the plot. Butch Cassidy summed it up for us: who are those guys?

Rage is not a policy. So said Tom Brokaw on the Feb. 23, 2017 edition of Morning Joe. He was talking about the Berkeley students rioting to block a controversial speaker from the campus. They are privileged people at that university. Mr. Brokaw said, and they cant hear somebody who comes and has a message [contrary to their ideas]? I think its outrageous The 2016 mess at Mizzou was somehow triggered by: a drunken white lout who used a slur in a black gathering; an anti-gay insult; and an anonymously drawn swastika in human feces. Oberlin College was overwrought over a non-existent Klansman and a racist and anti-Semitic prank played by students who said they were trolling. Yale melted down over opinions about Halloween costumes. Occupy Wall Street occupied space and made noise but never presented a set of demands at all. There are more. Who are those guys?

Howard S. Schwartz thinks he knows them and offers to make an introduction by means of a fascinating book titled, Political Correctness and the Destruction of Social Order: Chronicling the Rise of the Pristine Self. Mr. Schwartz uses psychoanalytic techniques to explain perplexing recent politically correct phenomena. He theorizes that we are seeing the actions of a kind of narcissist that demands that all contacts from the world at large be loving nurturing, and affirming, and who believes such a state of affairs to be a right, of which he or she has been deprived by the social structure.

Such people subconsciously wish to live in the imaginary state of infants who receive all nurture and protection from the mother. This state of affairs, which never existed outside of infantile perception, can only exist if the entire world is maternally nurturing and loving to them as opposed to being objective and demanding or even, merely indifferent. It is also atomistic because each such person wishes to be the center of the loving world.

However, the world in reality is objective, demanding and indifferent. Such people, therefore mistrust and even hate all social structure, seeing it as being inherently oppressive. Society to them is not an organically developed and positive, if flawed, system of guidelines, and agreed norms of behavior, but rather something wrongfully imposed, that blocks the maternal nurturing world they seek and steals from them their personal freedom and uniqueness. This they unconsciously and symbolically identify with the paternal principle. Hence they deeply resent and feel rage towards the patriarchal system, (and of course, white males), they attack toxic masculinity, and they seek to pull down the existing cultural structure without anything to replace it. After all, a replacement social structure is in fact, just another social structure.

The beliefs of such people take a religious quality. Therefore, what opposes them is evil. White males, as the creators/beneficiaries of the patriarchal system, and of white privilege, are the source of the evil. They and their works must be rooted out, even at the loss of the basic conventions necessary for people to interact. Consider the University of Washington, Takoma, which finds that grammatical standards are racist and must die. So much for laws, contracts, scholarship and even love letters.

Mr. Schwartz plentiful examples in the book, including several mentioned above, begin to make sense under his analysis. If he is right, the challenge for progressives and conservatives of good will is this: how does one compromise with people who have no program to propose? What is the sound of one hand clapping?

Joseph Sullivan chairs the advisory board for the Institute for Policy Innovation in Dallas.

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Why 'rage is not a policy' - Washington Times

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Cow eugenics: Colombian ranchers breed cattle to stand their ground against big cat predators – Genetic Literacy Project

Posted: at 3:19 pm

If big cats dont kill livestock, farmers wont shoot them.

Panthera, a charity that manages corridors for jaguars that stretchfrom Argentina to Mexico, guesses that just 5,000 of the cats are left in los llanos, Colombias scorching savannah. It has come up with a less violent way of protecting both the jaguars and the cattle.

The idea is to teach cattle self-defence, or rather to breed the instinct into them.

Pantheras idea is to replace panicky Zebu with cattle that stand their ground, or to interbreed the two.Esteban Payn, who directs Pantheras operations in northern South America, chose San Martineros, a little-known subspecies of Criollo cattle descended from Spanish fighting bulls. Few jaguars dare to challenge a massed group of 500kg (1,100-pound) San Martineros, their horns levelled. Docile with humans, they are fierce defenders of territory and their young.

Eugenics seems to work. Cattle that are just a quarter San Martinero may be just as brave, says Mr Payn. No jaguars have attacked cattle on Las Pampas, [a] 4,000-hectare ranch, since the programme began, he says. Zebu-only ranches in the area suffer a dozen attacks a year.

The GLP aggregated and excerpted this blog/article to reflect the diversity of news, opinion, and analysis. Read full, original post:Breeding cows that can defend themselves against jaguars

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Cow eugenics: Colombian ranchers breed cattle to stand their ground against big cat predators - Genetic Literacy Project

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