Daily Archives: February 24, 2017

SpaceX Dragon capsule finally arrives at the International Space Station after errors and delays – The Independent

Posted: February 24, 2017 at 5:56 pm

An important shipment has finally arrived at the International Space Station, after a series of errors, delays and challenges.

The SpaceX capsule smoothly arrived at the station the second time around as astronauts grabbed hold of the cargo ship, as the two of them floated somewhere over Australia.

The capsule had been scheduled to arrive on Wednesday. But a GPS error stopped it from getting too close and the move had to be aborted.

The Dragon - loaded with 5,500lbs of supplies - lifted off on Sunday from Nasa's historic moon pad at the Kennedy Space Centre in Florida.

Now leased by SpaceX, the pad had been idle since the close of the shuttle programme almost six years ago.

The station's six crew members will accept another shipment on Friday, this one from the Russians.

Given the Dragon's delayed arrival - lift-off also occurred a day late - the astronauts were under orders to open the capsule as soon as possible to retrieve sensitive science experiments.

"Sorry about the delays," Mission Control said. "Now the real work starts."

"Congratulations Dragon on a successful journey from Earth and now welcome on board," said French astronaut Thomas Pesquet, who used the station's big robot arm to grab the capsule.

At the top of the crew's unloading list: 20 mice that are part of a wound-healing experiment. Another 20 mice are taking part in the study on the ground, as control subjects.

Other newly arrived research: highly infectious MRSA bacteria, triple-contained so it does not get loose; stem cells; and instruments for studying lightning and the Earth's ozone layer.

Drone captures SpaceX rocket landing in Florida

The Dragon will remain at the space station for a month before it is cut loose to bring back science samples and other items.

It is the only supply ship capable of returning intact to Earth, as all the others burn up during re-entry.

SpaceX is one of two private companies flying up supplies for Nasa.

Besides the French astronaut, the space station is home to two Americans and three Russians.

Additional reporting by Press Association

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International Space Station crosses over Perth | Perth Now – Perth Now

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THIS is what Perth looks like at night from the International Space Station.

Italian Astronaut Ignazio Magnani posted the picture of Perth lit up by city lights after the famous space station crossed over the state.

If you were staring up at the stars around 8.20pm Thursday night you may have witnessed the rare event.

The ISS is a large spacecraft in orbit around Earth where astronauts live and conduct research. It has made it possible for people to have an ongoing presence in space since 1998.

Although the ISS has been circling the earth for almost two decades it doesnt often cross Perth at such a convenient time and so bright to see with the naked eye.

The space station was only visible for about five minutes. Mr Magnani alerted Perth to the crossing.

Did you manage to capture a glimpse? Some Perth astrophotgraphers did.

Another interesting photo tonight... The International Space Station flew over Perth from the north-west to the south-east at 8:22PM. I took this photo from Port Coogee, with Leonie. Thanks for the tip Dan! 🙂

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SpaceX cargo ship arrives safely at space station – USA TODAY

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USA Today Network James Dean, Florida Today Published 6:39 a.m. ET Feb. 23, 2017 | Updated 12:28 p.m. ET Feb. 23, 2017

SpaceX's Dragon cargo ship docked with the International Space Station on Thursday, a day after a GPS problem prevented the capsule from coming too close. AP

The SpaceX Dragon capsule flying the CRS-10 cargo resupply mission was captured by the International Space Station's robotic arm at 5:44 a.m. EST Thursday, Feb. 23, 2017.(Photo: NASA TV)

MELBOURNE, Fla.A SpaceX Dragon capsule carrying nearly 5,500 pounds of supplies and science experiments arrived safely at the International Space Station early Thursday, a day later than planned after an aborted rendezvousWednesday.

French astronaut Thomas Pesquet steered a 58-foot robotic arm to snare the unmanned Dragon at 5:44 p.m. EST, as the two spacecraft flew 250 miles above northwestern Australia.

"Looks like we got a great capture," crewmate and Expedition 50 commander Shane Kimbrough radioed to flight controllers in Houston.

"Great job with Dragon capture, and sorry about the delays," responded NASA astronaut Mike Hopkins, who was communicating with the crew from the ground. "Now the real work starts."

Related: SpaceX cargo ship scrapped docking at space station

Pesquet said the six-person space stationcrew was "very happy" to have Dragon on board and complemented the public-private partnership behind the commercial resupply mission that launched Sunday on a SpaceX Falcon 9 rocket from Kennedy Space Center.

"Such a strong partnership between agencies and commercial entities together with the international partners is without a doubt the future of space exploration, and were paving the way every day on the ISS," he said.

By 8:15a.m., robotics teams on the groundattached the Dragon to the Earth-facing port of the station's Harmony module for a monthlong stay.

The crew planned to open the Dragon's hatch later Thursday to begin removing time-sensitive science experiments.

More than half of the cargo is dedicated to science research, including a pair of NASA science instruments that will monitor Earth's ozone layer and lightning strikes. Another NASA instrument will test guidance systems for missions that would attempt to robotically service satellites.

Other research includes studies of tissue regeneration, involving 20 mice in orbit; of stem cells that could be applied to stroke treatments; and of protein crystals that could improve cancer drugs.

Related:SpaceX launches rocket from historic NASA launchpad

On Wednesday, the Dragon flew within about 1,200 feet of the station before backing out of its approach. NASA said flight computers triggered the abort after recognizinga problem with navigation data calculating the Dragon's position relative to the station.

Afterthe Dragon's berthing Thursday, aRussian Progress resupply ship, flying for the first time since a failed launch on Dec. 1, 2016, is scheduled to dock at the outpost around 3:30 a.m. EST Friday.

The next U.S. commercial cargo ship in line to fly, Orbital ATK's Cygnus, is being prepared for a March 19 launch from Cape Canaveral on a United Launch AllianceAtlas Vrocket.

Follow James Dean on Twitter: @flatoday_jdean

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Two chances to see International Space Station flyby this weekend – MyPalmBeachPost (blog)

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The International Space Station will make two appearances over Palm Beach County in the next few days.

But the spacecrafts passes are for early-risers only, appearing both Saturday and Monday before 7 a.m.

Check The Palm Beach Post radar map.

International Space Station

On Saturday, the space station will appear in the south at about 10 degrees above the horizon at 6:20 a.m. It should be visible for two minutes before disappearing in the southeast.

On Monday, the station will be visible beginning at 6:10 a.m. for a full six minutes. It will appear in the south-southwest at 11 degrees above the horizon and disappear in the northeast.

Related: Six months to total solar eclipse in the U.S.

EarthSky.org describes the Space Stations appearance from Earth as looking like a bright star moving quickly above the horizon. If you see lights blinking, its probably a plane.

On Thursday, Space Xs Dragon cargo vehicle successfully attached to the space station delivering supplies and experiments.

Download the Palm Beach Post WeatherPlus app here.

If you havent yet, join Kim on Facebook, Instagram and Twitter.

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First Black Crew Member To Join International Space Station – Thenewjournalandguide

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The National Aeronautics and Space Administration (NASA) has selected astronaut Jeanette Epps to join the crew of the International Space Station in 2018. Epps will become the first Black crew member to represent the U.S. on the station.

The journey will mark the first time Epps has traveled to orbit, allowing her to follow in the footsteps of the women who, she said, inspired her to become an astronaut.

While other Black astronauts have flown to the Space Station for brief stays during the outposts construction, Epps will be the first Black crew member to live and work on the station for an extended period of time. Her journey aboard the Soyuz spacecraft and stay at the station places her as the only American and female among a crew made up of mostly Russians and men.

Im a person just like they are. I do the same work as they do, Epps told a group of STEM students at her Syracuse alma mater, Danforth Middle School. If something breaks, any one of us will have to be able to go out the door. We have to be jacks of all trades. Its not a job thats like any other.

While working on her doctorate, Epps was a NASA graduate student Researchers Project fellow, authoring several journal and conference articles about her research. After completing her graduate studies, Epps worked in a research lab for more than two years, co-authoring multiple patents, before being recruited by the Central Intelligence Agency (CIA). She was a CIA technical intelligence officer for about seven years before being selected as a member of the 2009 astronaut class.

Anything you dont know is going to be hard at first, Epps said in a video statement about the launch. But if you stay the course, put the time and effort in, it will become seamless eventually.

Epps, in the NASA video interview, shared when she was first introduced to the idea that she could be an astronaut. It was about 1980, I was nine years old. My brother came home and he looked at my grades and my twin sisters grades and he said, You know, you guys can probably become aerospace engineers or even astronauts, Epps said.

And this was at the time that Sally Ride [the first American woman to fly in space] and a group of women were selected to become astronauts the first time in history. So, he made that comment and I said, Wow, that would be so cool.

Epps will join veteran NASA astronaut Andrew Feustel at the Space Station. On Feustels first long-duration mission, he served as a flight engineer on Expedition 55, and later as commander of Expedition 56.

By Shantella Y. Sherman (AFRO/NNPA Member)

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SpaceX Cargo Craft Fails To Dock With Space Station, Will Try Again – KALW

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Early Wednesday morning, a space capsule carrying 5,500 pounds of cargo approached the International Space Station.

The SpaceX Dragon cargo ship was scheduled to arrive at the station around 6 a.m. ET. If all went as planned, astronauts Thomas Pesquet of the European Space Agency and Shane Kimbrough of NASA would use a robotic arm on the station to reach out and grasp the ship, pulling it in and locking hatches with it.

But that cosmic embrace was not to be.

Around 3:25 a.m. ET, according to NASA TV, the navigation system on the unmanned Dragon cargo ship detected an error. A number was wrong in its GPS software. The ship automatically aborted its mission. It was about three-quarters of a mile away from the space station.

The docking has been rescheduled for Thursday morning.

"It did exactly what it was designed to do, breaking out of a rendezvous approach when it saw an incorrect value," said NASA TV commentator Rob Navias.

"This is an easily correctable issue," he explained during a live NASA TV stream of the docking attempt. "Dragon itself is in excellent shape."

The new schedule means Dragon will arrive at the International Space Station the day before a Russian resupply rocket, which launched early Wednesday and is set to arrive at the ISS early Friday morning.

As The Two-Way reported, today's is not the first delay for the SpaceX Dragon. The cargo ship was supposed to launch Saturday, but that was scrubbed just 13 seconds before liftoff because of an anomaly discovered in the rocket's steering system.

"On Sunday, however, the launch went smoothly," NPR's Colin Dwyer reported. "Not only did SpaceX's Falcon 9 rocket lift off without a hitch, its first stage also returned to land right back on a platform on Earth. Shortly afterward, the Dragon spacecraft it was carrying detached as planned from the rocket."

As The Wall Street Journal has reported, mistakes and setbacks in its rocket business have become an increasing concern for the commercial spaceflight company, in part because its founder Elon Musk has publicly announced that the company will build a system to colonize Mars.

As the newspaper reported, failed launches (the rockets exploded) in June 2015 and September 2016 contributed to a loss in revenue:

"Internal financial documents reviewed by The Wall Street Journal and interviews with former SpaceX employees depict robust growth in new rocket-launch contracts and a thin bottom line that is vulnerable when things go awry. They also show the company putting steep revenue expectations on a nascent satellite-internet business it hopes will eventually dwarf the rocket division and help finance its goal of manned missions to Mars."

In addition to stuff humans use to live in space, the cargo craft is carrying science experiments. "One experiment will use the microgravity environment to grow stem cells that are of sufficient quality and quantity to use in the treatment of patients who have suffered a stroke," a NASA press release read. The mission will also aid in recording "key climate observations and data records."

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Martian Politics Are a Mess and We Haven’t Even Arrived – Inverse

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The instantly iconic image of a barely ruffled American flag, perched proudly at the top of the Lunar Flag Assembly, ran on the front page of LIFE magazines August 8, 1969 issue. The photograph, part of a series taken by Neil Armstrong and Buzz Aldrin, wasnt just for American eyes. It was a masterful piece of propaganda that heavily implied the United States had taken a permanent lead in the space race by claiming the moon in much the same way it had claimed Hawaii a decade earlier. But no country owns the fifth-largest natural satellite in the solar system. And, unless changes are made to international laws, no country will own Mars even if NASA arrives on schedule in the 2030s.

Futurists have been talking about colonizing Mars since the German Jesuit scholar Athanasius Kircher got excited about a plan in the 17th century. But implicit in the idea of colonization is a premise that may not apply. Colonization connotes sovereignty and ownership. Those concepts define nations and international relations on Earth, but map poorly to the Martian surface for economic and legal reasons. Resources on Mars are limited and inefficiencies are massively expensive. Free markets arent likely to emerge rapidly. There are plenty of places Antarctica, Diego Garcia where similar constraints have led to the creation of more martial installations. But this process is much more complicated on Mars, because international treaties make it illegal for parties to claim land. (Flags can be planted, but they are just flags.) Given the high value of a scientific or military Martian installation and the lack of legal means to protect it, countries and private entities aiming for the red planet are taking a leap of faith in the adaptability of Earths political and culture technologies.

They are betting, in short, that Mars wont become a battlefield and, furthermore, that Martian conflicts wont result in crises on Earth. Its unclear if thats a smart bet.

The countries and companies (including SpaceX, NASA, the United Arab Emirates interested in colonizing Mars do have more to go on than optimism. They have the 1967 Outer Space Treaty, which was created in the midst of the Cold War as a framework for dealing with potential conflict in space. And it hasnt exactly made a smooth transition into the 21st century. The treaty is not only 40 years old and outdated, but represents the product of a negotiation between two hostile and neurotic superpowers looking to avoid nuclear holocaust, not share unclaimed territory.

Russia was worried that the United States was going to claim areas of space as their own, explains Jacob Haqq-Misra, a research scientist with Blue Marble Space Institute of Science. The U.S. was worried that [the USSR] was going to do the same. Both sides were worried that nuclear weapons might get placed into orbit or even on the moon.

The result? A treaty that creates a protocol for planetary protection, bans weapons of mass destruction in orbit, and explicitly forbids military installations beyond the atmosphere. Then there is the diciest part: Outer space is not subject to national appropriation by claim of sovereignty, by means of use or occupation, or by any other means.

But neither America nor SpaceX want outer space as such. They want continuous access to Helium-3, precious metals which are increasingly rare on Earth, and access to ice or liquid water which could be used in sustainable spaceflight technologies.

Theres an ambiguity in how you interpret the Outer Space Treaty, Haqq-Misra says. Its precisely this ambiguity that permits the U.S. and Luxembourg to justify the mining of resources in space. They claim states and companies operating under the purview of their states are not claiming sovereignty over land, merely claiming resources.

Haqq-Misra thinks its critical for the international community to have new ideas about space governance. He says this is especially important because private companies are likely to play a role going forward that no one envisioned in the late 1960s. Hes far from alone in thinking that the treaty is dated, but the solution to that problem remains unclear. As Frons von der Dunk, a space law expert at the University of Nebraska-Lincoln, points out, scrapping the whole thing might be throwing a lot of baby away with the bathwater given that it does not explicitly empower or disenfranchise any single entity. Ambiguity, however unintentional, allows for progress while avoiding a potential Martian land rush and the conflicts likely between the U.S. and Russia that could be provoked. And theres not a clear demand for an alternative because there is no emerging consensus on what international space law should look during the second space age. States are not rushing to sit down and hash the issues out.

I do not see that readily happening, says von der Dunk.

Which means that its time to get creative about governance. Haqq-Misra does that by working backwards from specific, plausible scenarios. As an example, he describes a Chinese mission to Mars following on the heels of the successful creation of a SpaceX outpost. Would China want to avoid, say, anything within a 200-kilometer radius of Elon Musks biodome? Probably not and they wouldnt have to either.

They are free to land within SpaceXs exclusive economic zone and, in fact, might do so because going to space is really difficult, says Haqq-Misra. They would probably need direct support from others who are already there.

This only presents a problem if China seeks to extract resources from lands cultivated whatever that looks like by SpaceX workers. Within a system built on traditional ideas of sovereignty and land rights, this wouldnt make much sense. Within a system he calls Cooperative Sovereignty, Haqq-Misra believes the interests of both parties, and humanity writ large, can be preserved. Along with his colleague Sara Bruhns, Haqq-Misra proposes a Martian economic system that seeks to encourage the type of scientific endeavors NASA and others want to pursue while providing incentives and rules to foster trade, mining, and habitation development. Every Martian colony would basically have an exclusive economic zone within a bounded radius of a given installation. Other nations could land in that area, but not claim it.

Its not simply that that land could host valuable resources under the surface. Any colony thats looking to do more than simply kick back in the minus 100 degree Fahrenheit temperatures and enjoy a gravity thats one-third of Earths would need space for water treatment plants, greenhouses for growing essential plants and vegetables, structures that can house massive 3D printers used to build more structures, communications equipment for chatting with friends back on Earth, facilities that can generate fuel from Martian methane, a place for Martian robots to be built and programmed, and so much more. We havent even begun to touch on what will be needed for recreation (imagine playing soccer or football on the red planet), religion (Martian church on Sunday, anyone?), schools, administrative headquarters, etc.

Cooperative Sovereignty takes its shape from protocols outlined by the Antarctic Treaty System and the Convention on the Law of the Seas, both of which allow nations to claim resource access without claiming land. The history of international conflict on the high seas is not particularly encouraging nor is the regular violation of the Law of the Seas but the limited history of human conflict in Antarctica is.

Not many people want to live there, says Haqq-Misra. Youve got a bunch of science bases and people, for the most part, cooperate. Theres no violence. Theres very little military presence. Theres a moratorium on industrial mining or any sort of resource extraction for I think another 30 or 40 years. A lot of scientists like that model and, to some extent, we are loosely in that mode of operation with space today. You have free access if youre a scientist in any nation to do research in space.

Still, its important to remember that Antarctica is almost devoid of valuable resources. There are some deposits of iron ore, gold, copper, nickel, and platinum, and even some reserves of coal, but theres not enough there to justify the expense of setting up an extensive mining operation built to withstand difficult conditions. Mars may prove similarly lacking in mineral riches, but Martian land could prove valuable in other ways, such as providing a base of operations for asteroid mining, or the development of extremely novel technologies that can only be made in a low-gravity setting. The Antarctica model works neatly when theres not much to fight over.

When there is, things can get problematic. The notion of Martian economic zones is derived from the ability of nations to claim resources within a certain distance of sovereign shorelines. In theory, fleets from other nations cannot fish in those waters. In reality, its not always so simple. Over the last decade, territorial disputes in the South China Sea, an incredibly important trade route, have become disturbingly common. Because the United Nations has no way of actually enforcing any rulings it makes, countries China in most cases have been allowed to pursue extralegal agendas.

There is unlikely to be a U.N. peacekeeping force on Mars.

To resolve disputes on Mars, Haqq-Misra and Bruhns came up with a mediating body modeled after the fairly weak Antarctic Secretariat, which helps manage disputes between nations who are fighting in the South Pole.

David Collins think this plan is naive.

Collins, a law expert at the City University of London, believes Mars has capitalism coming. Hes bullish on the idea of allowing private parties to lay sovereign claims to Mars, arguing that a strict motivation of profit could best facilitate productive development of Martian colonies.

In a 2010 paper, Collins wrote that common ownership and sharing of lands and resources disregards the unequal burden of costs, and associated risks discouraging investment and productive use. In his view, the incentive to make these productive uses of the land of Mars necessitates non-communal ownership because private property rights encourage the maximization of a resources potential because of the prospect of higher individual gains.

The rise in interest in Mars among private companies, however, makes profit a potential catalyst for both science and human progress. However, capitalist expansion could well lead to the proliferation of Earth problems inequality, war, oppression, corruption on another planet. It might make homo sapiens a multi-planetary species quickly, but it will not facilitate the sort of cultural or psychological transcendence that artists have often suggested lies among the stars.

And theres the third way, the rejection of government and market expansion in favor of true independence. It should not be taken as a given that Mars will be populated one outpost at a time. If terraforming goes well and self- sufficiency becomes possible either through the export of valuable goods or through local production of essentials, Mars could be its own country. Being Martian could take on a new meaning and the government of that country could form itself to suit the sentiment of the governed.

There are two narratives that arrive at this end. In the first, the planet is always independent and land is never claimed until it is claimed by a local government. In the second, the planet frees itself from Earth colonists.

At some point in the future [Martian colonists] may start rebelling against a faraway terrestrial government still claiming jurisdiction over them, says von der Dunk. Imagine the tea party but with titanium and magnetite. Because space war is impractical and wildly expensive, the ultimate result of that decision might be a contested claim of sovereignty. Chinas relationship with Taiwan might be a model of the future unhealthy Martian relationship with an Earth country.

Or maybe not.

I dont think it would take very long before you started to see the emergence of a new form of Martian society that is still very human, but a new type of human, says Haqq-Misra.

Photos via Imgur, YouTube, Robert Murray/Mars Society

Neel is a science and tech journalist from New York City, reporting on everything from brain-eating amoebas to space lasers used to zap debris out of orbit, for places like Popular Science and WIRED. He's addicted to black coffee, old pinball machines, and terrible dive bars.

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EMS alum working for SpaceX says travel to Mars within reach – Penn State News

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UNIVERSITY PARK, Pa. Its safe to say that Michael Policellis career goals are pretty ambitious: supporting the effort to launch manned missions to Mars in a quest to colonize our neighboring planet.

But Policelli, a Penn State graduate with a masters degree in aerospace engineering and bachelors degree in materials science and engineering, doesnt see it that way. Policelli, now a propulsion development engineer for SpaceX, a private aerospace manufacturer and space transport services company, uses his background in engineering to tackle the task one step at a time, regardless of its challenges.

Materials science and engineering gave me the background to be able to analyze a problem critically and come to a solution, said Policelli.

Thats an important skill because much of what SpaceX does, quite literally, goes where no one has gone before.

Policelli landed the competitive job in 2014 after completing an internship with the company, where he tested rockets at their McGregor, Texas, facility. He said his aerospace engineering background and his work with the Penn State Lunar Lion Team a student team developing a rocket system for lunar exploration to expand humanitys knowledge of the Moon bolstered his resume. But his materials science background really stood out.

While working at the Applied Research Laboratorys Laser Processing Division and the Penn State Lunar Lion Team, Policelli became comfortable troubleshooting concepts using 3-D printing and modeling using metal alloys. When vying for an internship, he stressed his experiences at Penn State and how he was actually making things instead of just talking about concepts.

Ultimately youre going to have to do a lot of learning when you get to any job, and this one is no different, said Policelli. So, if you can demonstrate that you can go out and teach yourself what you need to succeed at a task and then iterate until you succeed, thats what theyre looking for.

Policelli has been working on SpaceXs Merlin engine for the second stage of the companys Falcon 9 rocket, in support of several missions including one where he was able to see all of Earth from the viewfinder.

You see the ground shrinking away and the edge of Earth with a thin little layer of atmosphere and get that perspective of what its like to be in space, and its pretty breathtaking, said Policelli.

He said its an exciting time to be working for a company that plans travel to Mars within a decade. SpaceX is already delivering cargo to the International Space Station, and is slated to begin human flights there as early as 2018.

A SpaceX Dragon spacecraft, launched via the Falcon 9 rocket, on Thursday delivered 5,500 pounds of supplies and equipment to the International Space Station four days after launching from the Kennedy Space Center. Michael Policelli, a Penn State graduate with a masters degree in aerospace engineering and bachelors degree in materials science and engineering, works on stage two of the Falcon 9 rocket.

Image: Photo provided/SpaceX

A SpaceX Dragon spacecraft, launched via the Falcon 9 rocket, on Thursday delivered 5,500 pounds of supplies and equipment to the International Space Station four days after launching from the Kennedy Space Center. SpaceX recently launched ten Iridium NEXT satellites into space and plans more commercial launches for the communications company and for NASA during the next year.

Space is a big place, and were going to need a lot of players. Were going to need a lot of people working to build the future of space exploration and, ultimately, colonization, said Policelli. Its a pretty amazing opportunity and I definitely appreciate the path it took to come here and to be able to work with all the people that I do. I have an amazing team and its been very satisfying. Everyone is working hard and trying to do their very best to accomplish the mission.

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Two Different Genetic Conditions Can Combine to Cause Severe … – Genetic Engineering & Biotechnology News

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Scientists from the Rockefeller University have led a team of researchers to uncover how two different conditionsa genetic immunodeficiency and delayed acquired immunity--can combine to produce a life-threatening infection.

In the study ("Human Adaptive Immunity Rescues an Inborn Error of Innate Immunity"),published online inCell,Jean-Laurent Casanova, M.D., Ph.D., head ofSt. Giles Laboratory of Human Genetics of Infectious Diseasesand a Howard Hughes Medical Institute Investigator,and his colleagues focused on the case of an otherwise healthy young girl who developed a life-threatening infection from a common strain of bacterium. Most of us carry Staphylococcus aureuson our skin and in our nostrils. It can cause minor infections (staph infections), but in some people, it results in severe disease.

The young girl's illness was mysterious. She had no known risk factors that would lead her to develop the acute form of the disease, and none of her family members had contracted it. So Dr. Casanova's group set out to define the underlying cause of her disease by searching her DNA for mutations that might make her more susceptible to staph disease.They quickly identified a likely culprita single-letter substitution in the two copies of a gene that encodes for the TIRAP, or Toll-interleukin 1 receptor domain containing adaptor, protein, used by specific immune cells to flag invading bacteria.

In laboratory experiments, the researchers found that TIRAP is critical for cells in the immune system's first line of defense against invaders. These are cells that develop before we are born, with built-in recognition systems for a host of molecules that are frequently present on the surface of invaders.

"We were sure this was the explanation for the severity of her staphylococcal disease," says Dr. Casanova. "We thought we had it all figured out."

But things turned out to be more complicated. To test his hypothesis, Dr. Casanova decided to analyze the DNA of other members of the patient's family. They hadn't suffered from severe staph infections, so they should have had normal TIRAP genes. However, he found the oppositeall seven members of her family had the same mutation as the young patient.

The researchers now had two questions instead of just one. Why did this child get the invasive disease? And why were the rest of her family seemingly immune, even though they shared her immune-compromising mutation?

The answers lie in a second line of immune defense that is not encoded within our DNA at birth. These secondary defenses are dependent on cells that generate antibodies against foreign compounds. "This is not something we are born with, but instead it is resistance that we acquire over the course of our lifetime when we are exposed to new pathogens," Dr. Casanova explains.

The researchers found that the patient lacked antibodies against a single molecule, known as lipoteichoic acid (LTA), but the levels were normal for all of her family members. LTA is present on the surface of staphylococcal bacteria, and normally it is recognized by immune cells in both lines of defense.

The antibodies against LTA were able to restore the function of the patient's immune cells in culture systems, and the researchers went on to confirm their hypothesis using a mouse model of the disease.

The results explain both why the patient developed life-threatening disease and why her family members didn't.

"Her illness likely resulted from failures in both lines of immunity. In her family, the second layer of defense compensated for genetic defects in the first," explains Dr. Casanova. "More broadly, it offers insight into how two people with the same infection, and even the same DNA, can have very different illnesses."

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Vanessa Marcotte case: New DNA technology could help solve jogger’s slaying – CBS News

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PRINCETON, Mass. -- The highly-specialized DNA technology that investigators used to create a profile of a person of interest in the killing of Vanessa Marcotte could mean the difference between solving a crime and a cold case, CBS Boston reports.

Marcotte, a New York City Google employee, was 27 when she was killed while jogging near her parents Princeton home on August 7, 2016.

The technology has the potential to show police the killers face and give them desperately needed clues.

Worcester County District Attorney Joseph Early said Thursday that investigators used a combination of witness statements and a DNA profile developed with the help of scientists at private lab Parabon NanoLab to develop a description of a person of interest in the case. The person of interest is described as a Hispanic or Latino man, about 30 years old, with an athletic build, light or medium skin, and a shaved head or very short hair.

He added that the person of interest would have had scratches on his face, neck, hands and arms after the Aug. 7 attack, the Associated Press reports.

Early wouldnt say where investigators collected the DNA. When asked by a reporter whether the DNA was recovered from Marcottes fingernails, Early said, I cant speak to that, but he did have a lot of scratches.

Using a small amount of DNA, scientists at the Parabon NanoLab are able to predict certain physical features and develop a forensic profile of the person.

We focus on things that dont change with the environment, so we do pigmentation which is eye, hair, and skin color, as well as freckling, Dr. Ellen McRae Greytak, director of the Parabon NanoLab, told CBS Boston.

She added that the lab also focuses on the face and persons ancestry.

When investigators run out of options, Greytak said they contact her lab, oftentimes for help generating new leads on cold cases.

And what we do is we tell them of those 400 people in the area, you can eliminate 90-95 percent because they dont match this profile, Greytak said. And now you can focus on a manageable number of people.

From there, the investigators have more information to work with and become more hopeful of solving the case.

It is not yet possible to predict height and weight using the technology.

Anyone with information about the Vanessa Marcotte case is asked to call the Massachusetts State Police tipline at 508-453-7589.

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