Daily Archives: February 24, 2017

Pawtucket man arrested for narcotics in CF – WPRI 12 Eyewitness News

Posted: February 24, 2017 at 6:32 pm

CENTRAL FALLS, R.I. (WPRI) The odor of freshly burnt marijuana was strong Thursday, when members of the Central Falls Police Department ended up arresting a driver for narcotics on Cross Street.

Officers pulled over Daniel Gilbert, 23, of Pawtucket for alleged traffic violations. Gilbert advised officers he had recently been smoking marijuana and had some left in his vehicle, according to Lt. Christopher Reed. Due to the odor, officers requested a drug-sniffing K-9 officer to search the vehicle.

The dog ended up finding a green leafy substance in individually wrapped small plastic bags on the center console. Furthermore, in the consoles ashtray, the dog led officers to a sizeable amount of white powder determined to be cocaine.

Gilbert was charged with felony drug possession, held overnight at Central Falls Police headquarters, and faced a judge Friday morning at 6th District Court in Providence. He was granted $5,000 bail with surety on Thursdays charge, but ended up being held without bail for violating probation.

According to the Rhode Island Judiciarys website, he will be due back in court May 19.

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Nivalis Therapeutics (NVLS) Says Cavosonstat Phase 2 Clinical … – StreetInsider.com

Posted: at 6:32 pm

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Nivalis Therapeutics, Inc. (NASDAQ: NVLS), a pharmaceutical company historically focused on developing innovative solutions for people with cystic fibrosis (CF), today announced topline results from the Company's Phase 2 trial evaluating the efficacy and safety of cavosonstat at a dose of 400 mg in adult patients with CF who had one copy of the F508del-CFTR mutation and a second gating mutation, and were being treated with Kalydeco (ivacaftor). There were no dose limiting toxicities and cavosonstat was well tolerated in the trial. Cavosonstat, when added to Kalydeco therapy, did not demonstrate benefit in absolute change in percent predicted FEV1, the trials primary endpoint, or in sweat chloride reduction at 8 weeks.

Summary of Key DataThe data announced today are from a Phase 2, double-blind, randomized, placebo controlled, trial that evaluated the efficacy and safety of one dose of cavosonstat administered twice daily (BID) in adult patients with CF who were heterozygous for the F508del-CFTR mutation and a gating mutation, being treated with Kalydeco. The 12-week trial included a total of 19 adults who received treatment with cavosonstat (400 mg) added to Kalydeco (n=15) or with placebo added to Kalydeco (n=4). The trial included a 4-week withdrawal and follow-up period once patients had completed 8 weeks of dosing.

The primary endpoint of the trial was change in absolute percent predicted FEV1 from baseline to week 8. These primary and key secondary endpoints are shown in the table below.

Primary and Key Secondary Endpoint at Week 8

The increase in body mass index (BMI) reflecting a gain in weight in this study was similar to increases in BMI observed in two prior studies of cavosonstat in CF patients homozygous for F508del-CFTR. In one study, cavosonstat was administered over 4 weeks to CF patients who were not being treated with OrkambiTM and in the other study cavosonstat was administered over 12 weeks to patients who were being treated with Orkambi. End of treatment BMI data from these studies are summarized in the table below. These data suggest that GSNOR inhibition may have improved the nutritional status of patients with CF in these studies.

We are sincerely grateful to those who participated in this trial, including the patients, their families, the trial investigators and our employees, said Steven Shoemaker, M.D., Medical Director at Nivalis. We hope that the data from this trial will help inform the overall body of CF research, and help others in the design of future CF trials.

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Galapagos doses first healthy volunteer with CF combo GLPG2222 and GLPG2451 – P&T Community

Posted: at 6:32 pm

Galapagos doses first healthy volunteer with CF combo GLPG2222 and GLPG2451
P&T Community
Triple combinations of CF compounds in the portfolio have consistently shown restoration of healthy activity levels in in vitro assays with human bronchial epithelial (HBE) cells of patients with the F508del mutation. These combinations result in an ...

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The Bus Campaign That’s Giving UK Political Correctness a Run for … – CBN News

Posted: at 6:32 pm

LONDON -- The founder of a U.K. Christian TV network has found a unique way to share famous quotes from Jesus -- by displaying them on buses throughout London.

Revelation TV's Howard Conder explains how God gave him the vision for this campaign, called QuoteJesus.com.

"The Lord spoke to me very clearly about starting to put the words of Jesus on the buses in London," he told CBN News. "We have a website. We have the buses booked. We're now on our second campaign."

Conder, who started his career as a musician, says he now believes God is using his previous self-promoting skills to now promote Jesus.

"I experienced first hand how bands and performers were marketed ruthlessly," he explains in a video posted on the Quote Jesus website "In time, I became a Christian and saw things in a new light. I channeled that same energy and drive into which I had to working in a purpose greater than myself."

Conder says he's overcome many challenges to launch this campaign, which he believes will impact many thousands of lives.

"There's 17.5 million people who visit London," he said. "There's between 8-9 million who live here. So we've got so many people who will, subliminally, will at least be looking at those scriptures, and here we have one here: 'You will be with me in paradise.'"

So what does the future hold for this unique evangelist project?

"I believe that the future of Quote Jesus is something that's not just for here in London," Condor told CBN News. "It's across our nation. But it's also I believe could go global. Why with all the millions of Christians that are around today, all they need to do is just get on board literally with us. But to help us to bring the quotes of Jesus to this generation."

With so much political correctness in the U.K. seeking to silence the Christian voice, the hope is that these public displays of quoting Jesus will play a significant part in people going on their own personal journey towards faith in Christ.

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Op-ed: He’s just saying what we’re all thinking: How political correctness fails us in the age of Trump – The Eagle

Posted: at 6:32 pm

By Joe Henao | 6 hours ago | Updated 6 hours ago

I wasnt quite sure if it was a universal maxim, but I had heard friends of mine recite the humourous adage, hes just saying what were all thinking, fictitiously assuming the role of the cucked Trump supporter proclaiming their admiration for our new Commander-in-Chief and his knack for stating the obscene, perverse and politically incorrect.

Although the phrase was generally used as a low jab towards Trump and his groupies, it reveals much of what is inefficient, and theoretically damning, regarding liberals and their use of political correctness as a means, end and political action.

As a disclaimer, Id like to point out that the act of censoring our speech for the sake of inclusivity and general respect should be commonsensical. It is in no way harmful in and of itself, and we should press our peers to consider utilizing language that does not carry with it preconceived sexist, racist, ableist, etc. values that devalue people and their identities.

This should be of no debate. (Hint: punch those who do debate it.) It is when political correctness is simultaneously employed as both an act of resistance and as a means to true liberation when it falls short. I urge liberals to reconsider what they understand as revolutionary and legitimately useful. The struggle does not end here.

Popular aphorisms Trumpisms such as, He just tells it like it is, or Hes just saying what were all thinking, should exact to us the nature of the isms politically correct liberals desperately attempt to combat. Discrimination, injustice and violence are not structured within language; they are structured within the base of the reality we inhabit.

Language, the medium poltical correctness aims to alter, operates in the most symbolic of realms, existing not as a categorical truth, but as a way of understanding, relaying and reflecting the social landscape were subjected to navigate.

Postmodern deconstructionists such as Foucault and Derrida, whom left-liberals love to misconstrue, correctly conveyed to us how power, hierarchy and violence is transcribed and sustained through language. Are we so ridiculous to assume that their solution was to simply not speak? Of course not, and for precisely this reason these thinkers were not liberals, but critical leftists.

Our goal should, therefore, not be to constantly censor our speech, but to rewire the zero-level relations of society so that the linguistic lexicon available to us does not contain within it discrimination/violence. Simply put, political correctness aims to alter the superstructure of society, while the true root of the violence that exists within our language is reflective of the relations in the base of society. If we are to truly uproot injustice and attack it at its source, we must attack the base, not language.

He tells it like it is: In this sense, racism very literally, is. Hes just saying what were all thinking. Regardless of whether or not racism is communicated or expressed through language, it still exists, and is still being thought and experienced.

Political correctness does nothing but obscure a forever lurking issue, acting as the proverbial band aid struggling to suppress an open wound. Within our subjective reality, violence exists structurally whether we speak about it or not.

So then, what is to be done? Ultimately and this will no doubt elicit opinions from all ends of our political constellation we must radically reorganize the ways in which we relate to one another. What I am proposing is far too utopian for todays standards, especially considering the state of affairs following the election, but nonetheless, we should still aim for the eventuality of an alterity rationally built upon entirely different relations, and keep certain options on the intellectual backburner for future use. By all means, let us all be inclusive with our language and utilize every tool available to us in mitigating injustice, but know that the struggle does not end here.

Joe Henao is a junior in the School of International Service.

edpage@theeagleonline.com

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Another cloning success shows technology being used by everyday graziers – ABC Online

Posted: at 6:31 pm

Updated February 24, 2017 14:05:37

Graziers in central Queensland have cloned a prize cow, moving the technology from the lab to the paddock.

Owner of the new cloned calf, Bill Geddes, said the technology was becoming more viable for everyday producers and more graziers were using it.

Born via caesarean one week ago, Dasha was created by Richard Fry, of Clone International in Victoria.

He used a method called nuclear transfer, and his creation is the exact genetic copy of a cow from the Brangus breed (a cross between an Angus and a Brahman).

Mr Geddes said the decision to create a cloned calf rather than naturally breed an animal was made in an attempt to preserve the grey-colouring and Angus bloodline of the original Brangus cow.

"Over the years, we've bred quite a lot of calves from this old cow, and been able to breed her a number of different ways," he said.

"With the knowledge of what we've got and what we've bred, we thought it'd be a great opportunity to clone her, then breed from the new [cow], with the knowledge we learned from the old cow."

The Brangus's skin samples were taken to Melbourne and grown as embryos, before being impregnated through IVF into a recipient mother.

Of the 12 embryos implanted, only one survived, and went on to become Dasha.

"The percentage rate is always very low with the clones," Mr Geddes said.

"If you get one, you're very lucky and we got one."

Mr Geddes said he could see the potential for cloning in other areas of the commercial production cattle industry and he would not be surprised if the practice became more common.

He said there was great value in being able to re-create an animal after it had been processed through the abattoir and its full potential was known.

"With the [ability to] clone, they could slaughter the animal, find the one really good bull, and still be able to clone and breed from it," Mr Geddes said.

After the success of his first cloned calf on the property, Mr Geddes said he would definitely consider cloning in the future.

"You'd have to have an exceptional purpose to do it because it's quite expensive you wouldn't do it for practice," he said.

Topics: beef-cattle, cloning, rural, livestock, rockhampton-4700, vic

First posted February 24, 2017 08:39:00

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20 years after Dolly: Everything you always wanted to know about … – Bizcommunity.com

Posted: at 6:31 pm

Dolly was an important milestone, inspiring scientists to continue improving cloning technology as well as to pursue new concepts in stem cell research. The endgame was never meant to be armies of genetically identical livestock: Rather, researchers continue to refine the techniques and combine them with other methods to turbocharge traditional animal breeding methods as well as gain insights into aging and disease.

Before the decades of experiments that led to Dolly, it was thought that normal animals could be produced only by fertilisation of an egg by a sperm. Thats how things naturally work. These germ cells are the only ones in the body that have their genetic material all jumbled up and in half the quantity of every other kind of cell. That way when these so-called haploid cells come together at fertilisation, they produce one cell with the full complement of DNA. Joined together, the cell is termed diploid, for twice, or double. Two halves make a whole.

From that moment forward, nearly all cells in that body have the same genetic makeup. When the one-cell embryo duplicates its genetic material, both cells of the now two-cell embryo are genetically identical. When they, in turn, duplicate their genetic material, each cell at the four-cell stage is genetically identical. This pattern goes on so that each of the trillions of cells in an adult is genetically exactly the same whether its in a lung or a bone or the blood.

In somatic cell nuclear transfer, all the DNA comes from a single adult cell. Belkorin, CC BY-SA

In contrast, Dolly was produced by whats called somatic cell nuclear transfer. In this process, researchers remove the genetic material from an egg and replace it with the nucleus of some other body cell. The resulting egg becomes a factory to produce an embryo that develops into an offspring. No sperm is in the picture; instead of half the genetic material coming from a sperm and half from an egg, it all comes from a single cell. Its diploid from the start.

Dolly demonstrated that adult somatic cells also could be used as parents. Thus, one could know the characteristics of the animal being cloned.

By my calculations, Dolly was the single success from 277 tries at somatic cell nuclear transfer. Sometimes the process of cloning by somatic cell nuclear transfer still produces abnormal embryos, most of which die. But the process has greatly improved so success rates now are more like 10 percent; its highly variable, though, depending on the cell type used and the species.

More than 10 different cell types have been used successfully as parents for cloning. These days most cloning is done using cells obtained by biopsying skin.

Environment plays a huge role for some characteristics. Food availability can influence weight. Diseases can stunt growth. These kinds of lifestyle, nutrition or disease effects can influence which genes are turned on or off in an individual; these are called epigenetic effects. Even though all the genetic material may be the same in two identical clones, they might not be expressing all the same genes.

Cloning a winner doesnt guarantee success for the next generation. AP Photo/Darron Cummings

Consider the practice of cloning winning racehorses. Clones of winners sometimes also will be winners but most of the time theyre not. This is because winners are outliers; they need to have the right genetics, but also the right epigenetics and the right environment to reach that winning potential. For example, one can never exactly duplicate the uterine conditions a winning racehorse experienced when it was a developing fetus. Thus, cloning champions usually leads to disappointment. On the other hand, cloning a stallion that sires a high proportion of race-winning horses will result very reliably in a clone that similarly sires winners. This is a genetic rather than a phenotypic situation.

Even though the genetics are reliable, there are aspects of the cloning procedure that mean the epigenetics and environment are suboptimal. For example, sperm have elegant ways of activating the eggs they fertilise, which will die unless activated properly; with cloning, activation usually is accomplished by a strong electric shock. Many of the steps of cloning and subsequent embryonic development are done in test tubes in incubators. These conditions are not perfect substitutes for the female reproductive tract where fertilisation and early embryonic development normally occur.

Sometimes abnormal fetuses develop to term, resulting in abnormalities at birth. The most striking abnormal phenotype of some clones is termed large offspring syndrome, in which calves or lambs are 30 or 40 percent larger than normal, resulting in difficult birth. The problems stem from an abnormal placenta. At birth, these clones are genetically normal, but are overly large, and tend to be hyperinsulinemic and hypoglycemic. (The conditions normalise over time once the offspring is no longer influenced by the abnormal placenta.)

Recent improvements in cloning procedures have greatly reduced these abnormalities, which also occur with natural reproduction, but at a much lower incidence.

Removing genetic material from the nucleus of a cell. AP Photo/Thomas Terry

But the cloning research landscape is changing fast. The driving force for producing Dolly was not to produce genetically identical animals. Rather researchers want to combine cloning techniques with other methods in order to efficiently change animals genetically much quicker than traditional animal breeding methods that take decades to make changes in populations of species such as cattle.

One recent example is introducing the polled (no horns) gene into dairy cattle, thus eliminating the need for the painful process of dehorning. An even more striking application has been to produce a strain of pigs that is incapable of being infected by the very contagious and debilitating PRRS virus. Researchers have even made cattle that cannot develop Mad Cow Disease. For each of these procedures, somatic cell nuclear transplantation is an essential part of the process.

To date, the most valuable contribution of these somatic cell nuclear transplantation experiments has been the scientific information and insights gained. Theyve enhanced our understanding of normal and abnormal embryonic development, including aspects of aging, and more. This information is already helping reduce birth defects, improve methods of circumventing infertility, develop tools to fight certain cancers and even decrease some of the negative consequences of aging in livestock and even in people. Two decades since Dolly, important applications are still evolving.

This article was originally published on The Conversation. Read the original article.

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The evolution of how we consume baseball games – Newsday

Posted: at 6:31 pm

Vin Scully has hung up his microphone after 67 years as the Dodgers play-by-play man nearly half the entire history of Major League Baseball.

Still, there was plenty that came before him in the evolution of fans efforts to follow the action in real time when not sitting in the ballpark.

Here, in recognition of the first Scully-less season since 1949 and the return this weekend of the Yankees and Mets to TV and radio for spring games from Florida is a brief stroll through the timeline that led to live streaming on mobile phones, something that would have seemed like science fiction in 1876 . . . or 1976.

Commercial telegraphy is even older than the National League, and a good thing it was for early fans interested in what was going on in games they did not attend. By the late 1870s, businesses realized customers might enjoy updates on games being played around the country, and contracted with Western Union to obtain results every half inning. One early adopter was Massey's billiard hall in St. Louis, where fans presumably could play pool, drink adult beverages and follow games at the same time. (Shout-out to Peter Morris' 2006 book, "A Game of Inches.") Newspapers, which already were receiving updates via telegraph, caught onto the trend and started posting scores outside their offices.

Raw data was better than nothing, but even better was something with visual aids. Creative minds in places such as Nashville and Atlanta soon were conjuring boards illustrated with baseball diamonds and pegs that moved from base to base to represent players. The gimmick spread to New York in the late 1880s, including outside the offices of Joseph Pulitzer's "The World." In 1886, the opera house in Atlanta tried something wackier: actual, uniformed people moving around a faux diamond on the stage, based on results coming in via telegraph. (Shown: M.D. Compton's Baseball Illustrating Apparatus, U.S. patent 540, 089 issued May 28, 1895.)

By the 1890s, electricity began to add more information - and more pizzazz - to the updates fans had come to rely on, in the form of machines that recounted many aspects of game action, including lights that followed the path of players and/or the ball. Such displays got increasingly elaborate, including mechanized, miniature "players" who mimicked the actions of the actual athletes in the distant stadium. (Shown: Nokes ElectraScore from Popular Electricity Magazine, v.5, October 1912: 584.)

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The electronic bulletin boards outside newspaper offices not only kept fans informed into the early 20th century, but served as a communal experience that replicated the in-stadium vibe. World Series in the early 1910s attracted huge, raucous crowds in Manhattan and other major cities. Before, during and after Game 3 of the 1912 World Series between the Giants and Red Sox - played in Fenway Park - throngs clogged the streets in and around Times Square, often shouting complaints and/or encouragement at players who were more than 200 miles away. "There could have been no more interest shown in the game," The New York Times wrote, "had the scene been the ball grounds at Boston instead of Times Square."

Commercial radio was in its infancy when baseball first came to the new medium, on Aug. 5, 1921, when the Pirates defeated the Phillies, 8-5, in a game played at Forbes Field. Initially some radio announcers merely read scores via telegraph updates from another location, but soon they were sitting in the stadiums themselves and enhancing the drama rather than dryly reciting results. By the 1923 World Series between the Yankees and Giants, radio use was widespread, and Graham McNamee became the first true baseball broadcasting star. Radio has endured as a staple of baseball fandom, sometimes even for those in the ballpark. Dodgers fans used to bring transistor radios to listen to Scully at the massive Coliseum in the Dodgers' early L.A. years. The three New York teams were radio holdouts -- they did not allow games to be broadcast live until 1939.

Commercial TV still was largely experimental on Aug. 26, 1939, when Red Barber called the first televised major league game from Ebbets Field, in which the Reds and Dodgers split a doubleheader on station W2XBS (later WNBC.) There were only two cameras in use and not many people watching, but it marked the first time anyone outside a ballpark had observed major league players in action live. World War II slowed the spread of television drastically, but it grew rapidly in the post-war years, and the first World Series aired in 1947. More and more games began to be televised - locally and nationally - through the 1950s and 1960s, exposing the game at its highest level to a far vaster audience than ever before.

Cable television transformed baseball in the late 1970s and 1980s, starting with superstations that allowed fans all over the country to see teams such as the Braves, Cubs and Mets. ESPN furthered the expansion of nationally televised games, finally rendering the old notion of a national "Game of the Week" on Saturday afternoon as a quaint relic. Soon games on cable outlets far outnumbered those available on local broadcast channels. Later, the rise of regional sports networks - especially team-owned ones such as the Yankees' YES Network, which launched in 2002 - further consolidated the power and profitability of baseball's pay TV model.

The World Wide Web came along in the early 1990s, sparking the most recent evolution/revolution in live major league coverage, one that continues apace in 2017. Initially, the Internet primarily was a way to discuss the game with fellow fans and check up on news and results in real time, something that continues on 21st century social media. Then it became a vehicle, through Major League Baseball Advanced Media, to see video highlights. Now, increasingly, it is a way to watch live games streamed to PCs, laptops, tablets or smartphones. The Yankees were pioneers in the area, first offering live streaming (for a price) in 2010. SNY announced just this winter that it would begin streaming Mets games in 2017.

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Oh, one more thing: Newspapers have covered baseball pretty much from the time the game was invented, well before the major leagues came along, and with more depth than any medium mentioned above. And we still do today. Just sayin'.

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Only One In A Thousand PokStops Are Giving Out Pokmon GO’s Gen 2 Evolution Items – Forbes

Posted: at 6:31 pm


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Only One In A Thousand PokStops Are Giving Out Pokmon GO's Gen 2 Evolution Items
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While your local area might be flooded with new Gen 2 Pokmon in the wake of Pokmon GO's latest update, you might be finding that you're missing a few key ingredients in pursuit of some specific evolutions. That would be a set of evolution items ...

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The evolution of Edsa – Inquirer.net

Posted: at 6:31 pm

Edsa will always be best remembered for the historic, peaceful uprising that unseated a dictator.

Along the stretch of Edsa happened the People Power Revolution in 1986, during which Filipinos from all walks of life linked arms to topple the dictator, former President Ferdinand Marcos and to reclaim true democracy.

Over the past 31 years, Edsa then bore witness to a series of major transformations, as the rapid urbanization of the metropolis saw massive infrastructure and property development projects rising along this 24-kilometer stretch.

Today, Edsa remains a major thoroughfare in the metro but one that exudes a highly different character and vibe compared to more than three decades ago. Here are some of the property and infrastructure projects that have changed the landscape of this historic avenue.

Edsa Shrine

It was formally known as the Shrine of Mary, Queen of Peace, and sits at the crossroads of Edsa and Ortigas Avenue in Quezon City.

Established in December 1989 with Fr. Socrates Villegas as its first rector, the shrine was a brainchild of the late Manila Archbishop Jaime Cardinal Sin, who convinced the families of Paquito Ortigas and John Gokongwei to donate the lot.

Arch. Francisco Maosa designed the church with preparatory work from National Artist Leandro Locsin and Architect William Coscolluela.

National Artist Napoleon Abueva meanwhile designed the 14 Stations of the Cross and the main altar table cast in bronze; sculptor Ramon Orlina created the glass and stainless steel sculpture of the Risen Christ and other artworks; and Virginia Ty-Navarro sculpted the bronze statue of the Virgin Mary.

People Power Monument

Located at the corner of White Plains and Esda, the bronze tableau is comprised of 37 figures depicting the various sectors of the Philippine society that joined the People Power Revolution in 1986, surrounding Inang Bayan as the dominant figure.

Created by award-winning sculptor Ed Castrillo, it was installed in 1993 and had cost P100 million. It has since served as among the main venues for the governments commemorative activities.

LRT-1 North Extension

Dubbed the closing the loop project to connect Light Rail Transit 1 (LRT-1) to Metro Rail Transit (MRT-3) system, it involved construction of a 5.4-km elevated line from LRT-1s Monumento Station in Caloocan to MRTs North Avenue Station in Quezon City.

It was completed in 2010 with additional two stations, Balintawak and Roosevelt, both in Quezon City. The LRT-MRT common station has yet to be constructed.

Metro Rail Transit 3 (MRT-3)

Its full operation began in 2000 with a 17-km track comprising of 13 stations starting from North Avenue in Quezon City to Taft Avenue in Pasay. The rail project has a fleet of 73 Czech-made modern and air-conditioned rail cars, of which up to 60, in three-car trains, operate daily.

Manhattan Garden City

It is a residential development project expected to consist of 20 residential towers on a 5.7-hectare property at the Araneta Center in Quezon City.

Gateway Mall

Opened in 2004, the flagship mall of Araneta Center has five levels and directly linked to Araneta Coliseum and LRT-2. It has a total floor area of 100,000 square meters. Lakbay para sa Kapayapaan sa Edsa

The street mural project was launched in 2013, adorning the walls of Camp Aguinaldo, the general headquarters of the Armed Forces of the Philippines, in Quezon City.

It spans about 3.8 km, of which 1.7 km stretches along Boni Serrano Avenue; 1.3 km along Edsa; and 1 km along White Plainsmaking it the worlds largest peace mural.

C-5 Ortigas Avenue extension interchange

More known as Ortigas Flyover, it was completed in 2004 to decongest traffic volume on Edsa. It has two flyovers: a three-level, four-lane flyover along C-5 and two-lane left-turn flyover.

Robinsons Galleria Complex

It is the countrys first mixed-use facility that combined a mall, hotels, offices and condominium residences within one development.

On its site is the Robinsons Galleria Ortigas, the flagship mall of Robinsons Land Corp. established in 1990. The five-level shopping mall houses over 500 highly recognized local and international shops, dining outlets and service centers.

Other establishments in the complex are the two high-rise office towers, Galleria Corporate Center and the Robinsons-Equitable Tower, deluxe hotels Holiday Inn Galleria Manila and Crowne Galleria Manila, and the Galleria Regency.

SM Megamall

Considered one of the countrys biggest malls, the SM Megamall is among the pioneer shopping malls established by Henry Sy Sr. in 1991 when he started the malling phenomenon in the 90s.

From its initial total floor area of 311,898 sqm, SM Megamall has undergone several renovations since then to reach its current floor area of 474,225 sqm when the Mega Fashion Hallwhich houses some flagship international retail brandswas unveiled in 2014.

To celebrate its 25th year, the construction of a 50-story, curvy S-shape office tower has begun last year and is expected to open in 2019.

Edsa Shangri-La

Opened in August 1992 at Ortigas Center in Mandaluyong, it is the first of the five Shangri-La hotels and resorts in the country. It has a total of 632 rooms which consist of 607 guestrooms and 25 suites.

It also has four international restaurants, two lounges, cafe and bakeshop, two ballrooms and 19 meeting rooms, among other amenities and features.

Starmall Edsa-Shaw

Situated at the corner of Metro Manilas busiest avenues, it is directly linked to the MRT Shaw Station and hosts a busy transit terminal, drawing a huge cross-section of daily commuters and shoppers.

SMDC Light Residences

A three-tower project, it is strategically located at Madison Street corner Edsa in Mandaluyong and conveniently linked to MRT Boni Station. It boasts of five-star amenities, its own mall and is deemed perfect for people on the go.

Avida Towers Centera

The four-tower development in Mandaluyong provides a unique in-city living experience divided into five different zones.

(Sources: edsashrine.org, quezoncity.gov.ph, robinsonsproperties.com, robinsonsmalls.com, sminvestments.com, shangri-la.com, dotcmrt3.gov.ph, jica.go.jp, starmalls.com.ph, megaworldcorp.com, gatewaymall.com.ph, avidaland.com, smdc.com and Inquirer Archives)

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