Daily Archives: February 23, 2017

Jim Bailey column: Caught up in political correctness – The Herald Bulletin

Posted: February 23, 2017 at 1:20 pm

I used to think I was your conventional regular guy. I just went along to get along. Now I find out it isn't so.

First off, I was born to Caucasian parents. Now I'm told, whether I like it or not and regardless of how I treat others, I'm a racist. And I'm being asked to apologize for the actions of ancestors whose names I don't even know.

I'm fiscally and morally conservative and otherwise a social moderate. By today's standards that makes me a fascist.

I am incurably heterosexual, and I'm having trouble understanding why some other people have a different orientation. So the gay lobby automatically brands me a homophobic.

I've always been non-union. That, I'm told, makes me a traitor to the working class, and big business has me in its pocket.

Although I haven't had occasion to shoot a firearm since I was in the Army half a century ago, I believe in the Second Amendment and in people's right to own and use guns in a legal manner. Oh, but no, that makes me a member of the vast gun lobby. But the fact I think there are certain types of weapons that don't belong in civilian hands, on the other hand, makes me a radical gun-control advocate. I'm in a no-win situation.

I'm a Christian. That means Muslims label me an infidel and those of an atheist bent brand me a radical religious nut who wants to impose my beliefs on everyone else.

I'm in my 70s, which makes me a useless old man.

I am proud of my heritage and our inclusive American culture. That, I'm told, makes me a xenophobe (I keep having to go to the dictionary, too).

I champion the safety of myself and my family, and I support the police and the legal system. That makes me a right-wing extremist.

I believe in the defense and protection of the homeland for and by all citizens, which now makes me a militant.

I believe in hard work, fair play and appropriate compensation according to each individual worker's merits. Today that makes me an antisocialist.

This list, by the way, is based on something I saw on the internet recently. That makes me a plagiarist.

While I'm retired from a long career in the news media, the gamut of real news and fake news and alternative facts being thrown at us of late leads me to question much of what the media is feeding us, even sometimes the mainstream agencies. That must make me a reactionary.

And if that isn't enough, some of my friends and I have been tossed into something called a basket of deplorables.

As a result of all this, I'm not quite sure who I am anymore. Things are happening so quickly that I'm having trouble trying to adjust my thinking.

And now I'm becoming afraid to go into either restroom.

Jim Baileys column appears on Thursday. He can be reached by email at jameshenrybailey@earthlink.net.

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Jim Bailey column: Caught up in political correctness - The Herald Bulletin

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Thursday February 23, 2017 – Israel Hayom

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Thursday February 23, 2017
Israel Hayom
A new language was created not too long ago, in which what is good is actually bad, what is bad is not really that bad, and the basic values on which we were raised are blasted as outdated. That is the language of political correctness, by which ...

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Thursday February 23, 2017 - Israel Hayom

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The true story behind the Marie Stopes eugenics trial of 1923 – Catholic World Report

Posted: at 1:20 pm

In the 1920s, a legal victory against the rising eugenic tide was won by a Catholic doctor over prominent birth control advocate Marie Stopes. While Stopes is lauded today at a feminist hero, the story of the eugenics libel trial has been largely overlooked.

Marie Stopes in her laboratory in 1904. (Image via Wikipedia)

In 1923 in Britain, a Catholic doctor won an important victory in the battle against one of the most harmful ideologies of the 20th century: eugenics. The battle was fought in the law courts when British birth control advocate Marie Stopes sued Dr. Halliday Sutherland for libel.

Had Sutherland lost the case, opposition to eugenics in Britain would have suffered a blow, and would possibly have been silenced altogether. Sutherlands success was in large part because he was supported by the most consistently vociferous critic of eugenics in Britain at that time: the Catholic Church. But having won the legal battle, Sutherland subsequently lost the history war when the narrative of the losing side became the received history.

It is time to correct the record and, whats more, demonstrate why it matters today. Recent developments in biotechnology mean that eugenics is back. The issues in Stopes v. Sutherland are still relevant today and, when the centenaries of past events are commemorated in the next few years, it is essential that the correct narrative is used to influence the contemporary debate.

The centenary in 2023 of the Stopes v. Sutherland trial will be an opportunity to challenge the falsehoods of the last 100 years. Catholics can reflect on the Churchs record of standing up for ordinary people against the master plan of the elites. Remembering these events will help to educate and inspire those who will take up the cause in the contemporary debate.

Fake histories are warehouses to store fake news.

Theres lots of fake news around these days, isnt there? This article is about one of the sources of fake newsfake history.

Heres an example from the BBCs online biography of Marie Stopes:

In 1921, Stopes opened a family planning clinic in Holloway, north London, the first in the country. It offered a free service to married women and also gathered data about contraception. In 1925, the clinic moved to central London and others opened across the country. By 1930, other family planning organisations had been set up and they joined forces with Stopes to form the National Birth Control Council (later the Family Planning Association).

The Catholic church was Stopes fiercest critic. In 1923, Stopes sued Catholic doctor Halliday Sutherland for libel. She lost, won at appeal and then lost again in the House of Lords, but the case generated huge publicity for Stopes views.

Stopes continued to campaign for women to have better access to birth control

A second example of fake history is a 2015 press release from Marie Stopes International celebrating the 90th anniversary of the establishment of Stopes second London clinic:

90 years ago a woman called Marie Stopes made an extraordinary decision. She would open a service in the heart of London that offered women access to free contraception. In 1925, three years before women would win the right to vote, Marie Stopes bucked convention by showing women they had a choice regarding whether and when to have children.

On what grounds do I say that these items are fake? In my opinion, they are fake because of what they leave out.

There is no mention of Stopes eugenic agenda or of her intention to achieve, in her own words, a reduction of the birth rate at the wrong part and increase of the birth rate at the right end of the social scale.

No mention of her view that, as she put it in 1924:

From the point of view of the economics of the nation, it is racial madness to rifle the pockets of the thrifty and intelligent who are struggling to do their best for their own families of one and two and squander the money on low grade mental deficients, the spawn of drunkards, the puny families of women so feckless and deadened that they apathetically breed like rabbits.

No mention was made that she advocated the compulsorily sterilization of the unfit, nor of her lobbying the British Prime Minister and the Parliament to pass the appropriate legislation.

No mention of the vituperative language she used to describe those whom she desired to see sterilized: hopelessly bad cases, bad through inherent disease, or drunkenness or character wastrels, the diseasedthe miserable [and] the criminaldegenerate, feeble minded and unbalancedparasites.

No mention is made of the bedrock tenets of the Society for Constructive Birth Control and Racial Progress, set up by Stopes to run her clinics: to furnish security from conception to those who are racially diseased, already overburdened with children, or in any specific way unfitted for parenthood.

No reasons were given as to why the doctor opposed her. Dr. Sutherland opposed Stopes because he opposed eugenics. His opposition began many years before, when he was nominally a Presbyterian and in practice an atheist.

No mention was made of the fact that Dr. Sutherland specialized in tuberculosis, an infective disease of poverty. This fact is key, because it brought him into direct conflict with eugenicists (more commonly known at the time as eugenists). Eugenists believed that susceptibility to tuberculosis was primarily an inherited condition, so their cure was to breed out the tuberculous types. While Sutherland and others were trying to prevent and cure tuberculosis, influential eugenists believed their efforts were a waste of time. Furthermore, these eugenists thought tuberculosis was a friend of the race because it was a natural check on the unfit, killing them before they could reproduce.

Of course, both the BBC biography and the press release are brief summaries and, as such, cannot include all of the details that I have outlined. But thats not the point. The point is that neither item properly summarizes the issues. The excision of Stopes eugenic agenda makes her a secular saint. How could anyone oppose her in good conscience?

And thats the question that brought me to where I am now. As a grandson of Dr. Sutherland, I often wondered why he opposed her, because I used to believe the fake version of this story myself. No onefamily or otherwisetold me differently. Following many hours of research, including the examination of Dr. Sutherlands personal papers, I now know a different version of events.

Halliday Gibson Sutherland was born in 1882, and was educated at Glasgow High School and Merchiston Castle School, Edinburgh. He studied medicine at Edinburgh and Aberdeen, and he graduated in 1908. At that time, he came under the influence of Robert Philip, who pioneered modern anti-tuberculosis treatments.

Tuberculosis was responsible for one-ninth of the total death-rate in Britain at the time. Tuberculosis killed over 70,000 victims, and disabled at least 150,000 more each year. Given that the disease often killed the bread-winner of a family, it was the direct cause of one-eleventh of the pauperism in England and Wales, a charge on the State of one million sterling per annum, Sutherland wrote in 1911.

In 1910, Sutherland was appointed the Medical Officer for the St. Marylebone Dispensary for the Prevention of Tuberculosis. In 1911, he edited and contributed to a book on tuberculosis by international experts.

Sutherlands religious journey is pertinent to this story. He was baptized a Presbyterian. In August 1904, at the age of 22, he was in theory an agnostic and in practice an atheist, he would later write. Ten years later, there came the hazards of war, and for me the time had come when it was expedient to make my peace with God. At that point he was admitted to the Church of Scotland. He became a Catholic in 1919.

Also relevant to this story is the falling birth rate, and two groups which had strong views about population.

Britains birth rate increased from 1800 onwards. In 1876, it peaked at 36.3 per thousand, and began to fall. By the end of 1901 it had fallen 21 percent, and by nearly 34 percent by 1914.

Not everyone was worried about the fall in birth-rate; one group in particular, the Malthusians, welcomed the fall.

It was T.R. Malthus (1766-1834) who had observed: The power of population is indefinitely greater than the power of the earth to produce subsistence for man.

He drew up his natural law, that when the population increased beyond subsistence, the resulting competition for resources would lead to conflict, famine, and disease. Sexual abstinence was the way to keep the population at manageable levels. In the period of the Stopes v. Sutherland libel trial, the term Neo-Malthusian was used to differentiate Malthusians who advocated the use of contraceptives instead of abstinence.

Another group keenly interested in population were the eugenists. The word eugenics was coined by Sir Francis Galton, cousin of the naturalist Charles Darwin. But while the word was new, the idea was not; G.K. Chesterton described it as one of the most ancient follies of the earth.

In the decades before the Stopes v. Sutherland libel trial, eugenists were concerned about the differential birth rate, so-called because the poor were producing more children than the rich. Given that British eugenists used social class as a proxy for a persons racial fitness, it was clear that the worst stocks would be the progenitors of Britains future population. For this reason, British eugenists fretted about degeneration and race suicide.

While there was rivalry between the Malthusian League and the Eugenics Education Society, and they differed strongly over the use of contraceptives, both groups agreed that in relation to population, quality mattered. The areas of overlap meant that some people were members of both the League and the Society. One such person was Marie Stopes.

The reader of this article might assume that doctors cure diseases; this, however, was not always a pressing concern for some influential minds in medicine and science at the beginning of the 20th century, particularly in relation to tuberculosis.

Sir James Barr, president of the British Medical Association (BMA), provides an excellent example of the attitude of many of those in the medical establishment of the time. At the BMAs annual conference in Liverpool in 1912, Barr was explicit that moral and physical degenerates should not be allowed to take any part in adding to the race. He then he turned his attention to tuberculosis:

If we could only abolish the tubercle bacillus in these islands we would get rid of tuberculous disease, but we should at the same time raise up a race peculiarly susceptible to this infectiona race of hothouse plants which would not flourish in any other environment. Nature, on the other hand, weeds out those who have not got the innate power of recovery from disease, and by means of the tubercle bacillus and other pathogenic organisms she frequently does this before the reproductive age, so that a check is put on the multiplication of idiots and the feeble-minded. Natures methods are thus of advantage to the race rather than to the individual.

Sutherlands opposition to this mindset and to eugenics can be traced to the article The Soil and the Seed in Tuberculosis, published in the British Medical Journal on November 23, 1912. In it, he recognised that doctors had traditionally believed in an inherited disposition to tuberculosis, and admitted that he had been one of them. Now he had changed his mind.

Sutherland again spoke out against eugenics on September 4, 1917, when he addressed the National Council of the YMCA. He rebutted the notion that consumption was hereditary, and he attacked the eugenists:

But why should you set out to prevent this infection and to cure the disease? There are some self-styled eugenistswho declaim that the prevention of disease is not in itself a good thing. They say the efficiency of the State is based upon what they call the survival of the fittest. [World War I] has smashed their rhetorical phrase. Who talks now about survival of the fittest, or thinks himself fit because he survives? I dont know what they mean. I do know that in preventing disease you are not preserving the weak, but conserving the strong.

His disagreement with eugenists, previously on medical and scientific grounds, was now on ethical and moral grounds as well.

In March 1918, Marie Stopes book Married Love was published, became a bestseller, and made her a celebrity. According to biographer June Rose:

Marie had written Married Love for women like herself, educated middle-class wives who had been left ignorant of the physical side of marriage. Her tone in her book and in the letters of advice sent to readers implied that they shared a community of interests and of income. She had no particular interest in the lower classes and in Wise Parenthood had written censoriously of the less thrifty and conscientious who bred rapidly and produced children weakened and handicapped by physical as well as mental warping and weakness. The lower classes were, she wrote in a letter to the Leicester Daily Post, often thriftless, illiterate and careless.

It was in her other books that the eugenic agenda was more clearly expressed. In Radiant Motherhood, she urged the compulsory sterilization of wastrels, the diseasedthe miserablethe criminal.

Stopes and her husband opened the Mothers Clinic in Marlborough Road, Holloway on March 17, 1921. She established the Society for Constructive Birth Control and Racial Progress to run the clinic. She engaged eminent people as vice-presidents of her society, including Bertrand Russell, H.G. Wells, John Maynard Keynes, and Sir James Barr.

Birth Control

On July 7, 1921, Sutherland attended a talk at the Medico-Legal Society by Dr. Louise McIlroy, professor of Obstetrics and Gynecology and first female professor at the Royal Free Hospital. In the discussion that followed her presentation, McIlroy addressed the negative physical effects of contraceptives. Sutherland, by this time a Catholic, wrote an article in which he observed that the medical profession now concurred with Catholic doctrine. The editor of The Month, in which the article appeared, suggested that he develop it into a book.

Sutherland wrote Birth Control: A Statement of Christian Doctrine Against the Neo-Malthusians. Despite the title, the book was very political and it described Malthusianism as an attack on the poor. It was a polemic for the fair treatment of the poor, and for an equitable structure in society to share the abundance of wealth. His conclusion foreshadows the demographic problems that developed nations face today:

The Catholic Church has never taught that an avalanche of children should be brought into the world regardless of the consequences. God is not mocked; as men sow, so shall they reap, and against a law of nature both the transient amelioration wrought by philanthropists and the subtle expediences of scientific politicians are alike futile. If our civilisation is to survive we must abandon those ideals that lead to decline.

In Birth Control, under the heading Exposing the Poor to Experiment, Sutherland wrote:

But, owing to their poverty, lack of learning, and helplessness, the poor are natural victims of those who seek to make experiments on their fellows. In the midst of a London slum a woman, who is a doctor of German philosophy (Munich), has opened a Birth Control Clinic, where working women are instructed in a method of contraception described by Professor McIlroy as the most harmful method of which I have had experience. When we remember that millions are being spent by the Ministry of Health and by Local Authoritieson pure milk for necessitous expectant and nursing mothers before and after childbirth, for the provision of skilled midwives, and on Infant Welfare Centresall for the single purpose of bringing healthy children into our midst, it is truly amazing this monstrous campaign of birth control should be tolerated by the Home Secretary.

Shortly after the book was published on March 27, 1922, Humphrey Roe, Stopes husband, wrote to Sutherland inviting him to publicly debate his wife. Sutherland did not respond to the letter, and a month later, he received a writ for libel.

Part II of this story will be published at CWR next week.

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Robert VerBruggen Is Not a Nazi, But Eugenics Isn’t Rocket Science – The American Conservative

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Im tempted to say, in response to Robert VerBruggens lament, that yes, thats Twitter for you, and this is one of many reasons why Im not on it. But Ithink there is more to say about the problem of eugenics than merely its immoral but not ineffective.

First of all, as Im sure VerBruggen would agree, not all efforts to improve the gene pool are immoral, and though we may disagree about exactly where the line is, we both surely agree that its laudableto get tested for Tay-Sachs before you marry, and we both surely agree that forced sterilization of undesirables is an abomination. For myself, Ive written about this before, and I stand by what I wrote then.

Second, we shouldprobably limit the word eugenics to collectiveprograms to improve the gene pool, and not apply the word to individual choices about who to have children with, because only collective programs can actually change the population as a whole. As such, its important to recognize that to breed for particular traits, you have to prevent elements within the population thatdont have those traits from breeding. For example, if you assume that intelligence is highly heritable, and wanted to increase the intelligence of the population, it wouldnt do to get smart people to marry other smart people. Youd have to get smart people tooutbreed less-smart people. I cant think of away to do this that is both ethical and plausible and most of the ways I can think of are neither.

Finally, while we know from extensive experience in selectively breeding animals and plants that such programs work, by work we meanthat weve maximizedparticular traits, abilities and behaviors. And in the course of doing so, you always get tradeoffs. The swift greyhound has chronic hip problems. The highly-trainable poodle is also prone to stress. The large-breasted chicken cant fly. And so forth.

There is no reason to doubt that the same would be true of humans, and that any serious attempt to breed people for particular traits even if undertaken on an entirely voluntary basis and involving no abortion or sterilizationor whatnot would have unexpected side effects. Perhaps breeding for ambitionwill result in lower empathy. Perhaps breeding for intelligence will result in greater incidence of anxiety anddepression. Perhaps breeding for greater athletic prowess will result in higher rates of marital infidelity and divorce. Who knows?

We dont and we cant ethically conduct the kinds of controlled experiments that would allow us to determine with high confidence that we had avoided unexpected side effects. That cautionholdsaswell for genetictherapies that are surely on the horizon. Fitness is only meaningfulrelative to a set of environmental conditions. Narrow the set of traits by which you definefitness and you have implicitly narrowed the set of environments within which an organism will prove fit. Which is not, generally, a good way for a species to maximize its survival prospects.

Im not arguing that people should blithely ignore genetic history or the science of inheritance more generally in matters like mate selection. (If I did, nobody would listen to me anyway.) But I am arguing both for humility and for a broad understanding of what constitutes fitness. Someone especially smart who says, I need to marry someone just as smart as I am so that ourchildren are likely to be similarly smart and hence similarly successful is not only running the risk of disappointment due to mean-reversion (which remainsa factor even when you stack the deck in your favor), but running the risk of having ignored other vital dimensions of the human personalityby reducing fitness to a narrow, measurable trait.

(Also, if you want a good marriage, you should probably marry someone who you love and desire, who is good for you and who you are good for, andwith whom you share certain core values and a robustability to communicate,rather than thinking of your spouse primarily as breeding stock. Not to mention not treating your children as pint-sizedsuccess machines. And staying off Twitter when your wife is in the next room with the OB/GYN. Just saying.)

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Robert VerBruggen Is Not a Nazi, But Eugenics Isn't Rocket Science - The American Conservative

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20 years after Dolly the sheep’s debut, Americans remain skeptical … – Pew Research Center

Posted: at 1:19 pm

Twenty years ago today, the worlds first clone made from the cells of an adult mammal made her public debut. Dolly, a Finn Dorset sheep, was introduced to the public in 1997 after scientists at the Roslin Institute at the University of Edinburgh in Scotland implanted the cell nucleus from a sheep into an egg that was subsequently fertilized to create a clone.

Dollys debut set off a firestorm about both the practical value and ethics of cloning, including the possibility of human cloning. Currently, more than 40 countries including the UK, France, Germany and Japan formally ban human cloning. In other countries, including the U.S. and China, there is no legal prohibition on it.

On the anniversary of Dollys unveiling, here are five noteworthy findings about cloning and public opinion:

1 No one has ever cloned ahuman being, though scientists have cloned animals other than Dolly, including dogs, pigs, cows, horses and cats. Part of the reason is that cloning can introduce profound genetic errors, which can result in early and painful death. At the same time, labs in a variety of countries have successfully cloned human embryos for the purpose of producing stem cells that can be used in medical therapies.

2 Eight-in-ten American adults (81%) say cloning a human being is not morally acceptable, according to a May 2016 Gallup poll. There has been overwhelming opposition to human cloning since 2001. Just 13% of adults in 2016 say cloning is morally acceptable.

3 Americans are divided as to whether humans will be cloned in the near future. In a 2010 Pew Research Center survey, 48% of adults said that a human being would definitely or probably be cloned by 2050, compared with 49% who said such an event would not happen.

4 The public is divided about the prospect of using cloning to bring back to life species of animals that are currently extinct, such as the carrier pigeon or even the woolly mammoth. While bringing back dinosaurs, la Jurassic Park, might not possible due to the fact that dinosaurs have been dead for tens of millions of years, scientists could conceivably use fresher tissue samples to bring back more recently extinct species. In a 2013 Pew Research Center poll, half of all adults surveyed (50%) said that by 2050 researchers will be able to use cloning to bring back extinct species, with 48% predicting such a development wont occur.

5 Fewer Americans are concerned with cloning animals than with the prospect of cloning humans, according to the same 2016 Gallup survey. Still, a majority of adults (60%) say cloning animals like Dolly is morally wrong, compared with 34% who say its morally acceptable. Since 2001, there has been little to no change in these numbers.

Topics: Emerging Technology Impacts, Religion and Society, Religious Beliefs and Practices, Science and Innovation

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20 years after Dolly the sheep's debut, Americans remain skeptical ... - Pew Research Center

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20 Years After Dolly, Where Are We With Cloning? – Inverse

Posted: at 1:19 pm

By George Seidel, Colorado State University

Its been 20 years since scientists in Scotland told the world about Dolly the sheep, the first mammal successfully cloned from an adult body cell. What was special about Dolly is that her parents were actually a single cell originating from mammary tissue of an adult ewe. Dolly was an exact genetic copy of that sheep a clone.

Dolly captured peoples imaginations, but those of us in the field had seen her coming through previous research. Ive been working with mammalian embryos for over 40 years, with some work in my lab specifically focusing on various methods of cloning cattle and other livestock species. In fact, one of the coauthors of the paper announcing Dolly worked in our laboratory for three years prior to going to Scotland to help create the famous clone.

Dolly was an important milestone, inspiring scientists to continue improving cloning technology as well as to pursue new concepts in stem cell research. The endgame was never meant to be armies of genetically identical livestock: Rather, researchers continue to refine the techniques and combine them with other methods to turbocharge traditional animal breeding methods as well as gain insights into aging and disease.

Dolly was a perfectly normal sheep who became the mother of numerous normal lambs. She lived to six and a half years, when she was eventually put down after a contagious disease spread through her flock, infecting cloned and normally reproduced sheep alike. Her life wasnt unusual; its her origin that made her unique.

Before the decades of experiments that led to Dolly, it was thought that normal animals could be produced only by fertilization of an egg by a sperm. Thats how things naturally work. These germ cells are the only ones in the body that have their genetic material all jumbled up and in half the quantity of every other kind of cell. That way when these so-called haploid cells come together at fertilization, they produce one cell with the full complement of DNA. Joined together, the cell is termed diploid, for twice, or double. Two halves make a whole.

From that moment forward, nearly all cells in that body have the same genetic makeup. When the one-cell embryo duplicates its genetic material, both cells of the now two-cell embryo are genetically identical. When they in turn duplicate their genetic material, each cell at the four-cell stage is genetically identical. This pattern goes on so that each of the trillions of cells in an adult is genetically exactly the same whether its in a lung or a bone or the blood.

In contrast, Dolly was produced by whats called somatic cell nuclear transfer. In this process, researchers remove the genetic material from an egg and replace it with the nucleus of some other body cell. The resulting egg becomes a factory to produce an embryo that develops into an offspring. No sperm is in the picture; instead of half the genetic material coming from a sperm and half from an egg, it all comes from a single cell. Its diploid from the start.

Dolly was the culmination of hundreds of cloning experiments that, for example, showed diploid embryonic and fetal cells could be parents of offspring. But there was no way to easily know all the characteristics of the animal that would result from a cloned embryo or fetus. Researchers could freeze a few of the cells of a 16-cell embryo, while going on to produce clones from the other cells; if a desirable animal was produced, they could thaw the frozen cells and make more copies. But this was impractical because of low success rates.

Dolly demonstrated that adult somatic cells also could be used as parents. Thus, one could know the characteristics of the animal being cloned.

By my calculations, Dolly was the single success from 277 tries at somatic cell nuclear transfer. Sometimes the process of cloning by somatic cell nuclear transfer still produces abnormal embryos, most of which die. But the process has greatly improved so success rates now are more like 10 percent; its highly variable, though, depending on the cell type used and the species.

More than 10 different cell types have been used successfully as parents for cloning. These days most cloning is done using cells obtained by biopsying skin.

Genetics is only part of the story. Even while clones are genetically identical, their phenotypes the characteristics they express will be different. Its like naturally occurring identical twins: They share all their genes but theyre not really exactly alike, especially if reared in different settings.

Environment plays a huge role for some characteristics. Food availability can influence weight. Diseases can stunt growth. These kinds of lifestyle, nutrition or disease effects can influence which genes are turned on or off in an individual; these are called epigenetic effects. Even though all the genetic material may be the same in two identical clones, they might not be expressing all the same genes.

Consider the practice of cloning winning racehorses. Clones of winners sometimes also will be winners but most of the time theyre not. This is because winners are outliers; they need to have the right genetics, but also the right epigenetics and the right environment to reach that winning potential. For example, one can never exactly duplicate the uterine conditions a winning racehorse experienced when it was a developing fetus. Thus, cloning champions usually leads to disappointment. On the other hand, cloning a stallion that sires a high proportion of race-winning horses will result very reliably in a clone that similarly sires winners. This is a genetic rather than a phenotypic situation.

Even though the genetics are reliable, there are aspects of the cloning procedure that mean the epigenetics and environment are suboptimal. For example, sperm have elegant ways of activating the eggs they fertilize00071-4/abstract), which will die unless activated properly; with cloning, activation usually is accomplished by a strong electric shock. Many of the steps of cloning and subsequent embryonic development are done in test tubes in incubators. These conditions are not perfect substitutes for the female reproductive tract where fertilization and early embryonic development normally occur.

Sometimes abnormal fetuses develop to term, resulting in abnormalities at birth. The most striking abnormal phenotype of some clones is termed large offspring syndrome, in which calves or lambs are 30 or 40 percent larger than normal, resulting in difficult birth. The problems stem from an abnormal placenta30217-5/abstract). At birth, these clones are genetically normal, but are overly large, and tend to be hyperinsulinemic and hypoglycemic. (The conditions normalize over time once the offspring is no longer influenced by the abnormal placenta.)

Recent improvements in cloning procedures have greatly reduced these abnormalities, which also occur with natural reproduction, but at a much lower incidence.

Many thousands of cloned mammals have been produced in nearly two dozen species. Very few of these concern practical applications, such as cloning a famous Angus bull named Final Answer (who recently died at an old age) in order to produce more high-quality cattle via his clones sperm.

But the cloning research landscape is changing fast. The driving force for producing Dolly was not to produce genetically identical animals. Rather researchers want to combine cloning techniques with other methods in order to efficiently change animals genetically much quicker than traditional animal breeding methods that take decades to make changes in populations of species such as cattle.

One recent example is introducing the polled (no horns) gene into dairy cattle, thus eliminating the need for the painful process of dehorning. An even more striking application has been to produce a strain of pigs that is incapable of being infected by the very contagious and debilitating PRRS virus. Researchers have even made cattle that cannot develop Mad Cow Disease. For each of these procedures, somatic cell nuclear transplantation is an essential part of the process.

To date, the most valuable contribution of these somatic cell nuclear transplantation experiments has been the scientific information and insights gained. Theyve enhanced our understanding of normal and abnormal embryonic development, including aspects of aging, and more. This information is already helping reduce birth defects, improve methods of circumventing infertility, develop tools to fight certain cancers and even decrease some of the negative consequences of aging in livestock and even in people. Two decades since Dolly, important applications are still evolving.

George Seidel, Professor of Biomedical Sciences, Colorado State University.

This article was originally published on The Conversation. Read the original article.

Photos via Belkorin, AP Photo/Darron Cummings, AP Photo/Thomas Terry, Getty Images / Jeff J Mitchell

The Conversation US is an independent source of news and views from the academic and research community, delivered direct to the public. The Conversation has access to independent, high quality, authenticated, explanatory journalism underpins a functioning democracy.

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20 Years After Dolly, Where Are We With Cloning? - Inverse

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Pabrai And The Shameless Cloning Portfolio – Seeking Alpha

Posted: at 1:19 pm

Terrific value investor Mohnish Pabrai teamed up with quant Fei Li to test a cloning strategy. Mohnish Pabrai is a fervent proponent and practitioner of cloning and mostly confines his investment universe to 13-F's of investors he thinks of as highly capable. Studies like this one on Buffett have shown 13-F's can be valuable sources of Alpha although these usually do have an important defect I'll address later. Pabrai created an ETF called the Dhandho Junoon ETF (NYSEARCA:JUNE) based on three distinct strategies of which cloning is one:

To prove his cloning strategy works Pabrai and Fei Li set up an experiment. Pabrai selected eight value managers and himself and Fei Li designed a randomization method to pick five stocks from a random portfolio between these nine managers':

Manager Number

Value Manager

1

Appaloosa Management

2

Cedar Rock Capital

3

FPA Capital

4

Greenlight Capital

5

Markel Insurance

6

Pabrai Investment Funds

7

Sequoia Fund

8

TCI Fund Management

9

ValueAct Capital

The algorithm always selected the largest (highest conviction) pick unless it was disqualified by the additional rules of the algorithm or it had already been selected.

The additional rules further weaken the test results:

Selection Criteria

No utilities, no REITs, no oil and gas exploration, no metals and mining and no multiline retailers.

Positive trailing-12-month net income

The random portfolios ended up doing really well:

Source: Forbes

Criticism

Even though the margin of outperformance is large I wouldn't put too much faith in this 10% outperformance holding up in the future.

Why didn't they run this backtest a gazillion times and publish aggregated results? It seems strange to run it just once as it is clearly a very volatile method because of the limited number of stocks chosen, the concentration in the value strategy.

What invalidates all these types of backtests is the researcher, or in this case Pabrai, starts out with a known big winner or winning group and subsequently comes up with the result they outperformed.

They use this to argue 13-F's contain valuable information that can be arbitraged and I believe that's true. But it is a flawed argument because we didn't know these managers were this good back in 2000. Some didn't even file 13-F's yet at the start date of the experiment.

When Warren Buffett wanted to make a point Hedge Funds wouldn't beat the S&P 500 he didn't say here's proof "look at my backtest". He said let's bet a million dollars to a hedge fund guy.

Source: Longbets

The additional selection criteria have nothing to do with the original premise. Why taint the results by including these. Pabrai could easily have knowledge of a particular spectacular failure by one of these 9 managers. For example the positive trailing 12 month net income criteria heightened the odds of the algorithm avoiding the spectacular Valeant (NYSE:VRX) disaster a prominent Sequoia position for a long time. Even with Valeant Sequoia outperformed but without it, the record is truly outstanding.

In addition most of the industries Pabrai selected for exclusion have underperformed the S&P 500 by a sizeable margin most especially in the later years which greatly influences compounded returns:

^SPXTR data by YCharts

^SPXTR data by YCharts

^SPXTR data by YCharts

^DJUSIM data by YCharts

^MSACMRTTR data by YCharts

My final point of criticism being that is seems a little bit unfair to include long/short managers like David Einhorn. We don't know how Einhorn manages risk exactly but he had only two down years ever. Short books generally limit volatility and it may have enabled Einhorn to be very aggressive with his long book due to eliminating some market risk. When we know after the fact, a managers bets have panned out and we can select from the great half of his portfolio as shorts aren't disclosed on 13-F's outperforming the S&P 500 starts to become easy game.

Even after my critical aside I do believe Pabrai's ETF is going to work and the 13-F strategy will work if you are good at identifying the right investors to follow.

The ETF combines strong strategies where there's compelling evidence they have been working and credible behavioral, systematic and other explanations of why they could continue to outperform.

Pabrai brandished his experiment the Shameless Portfolio and the algorithmic picks for 2017 are:

Oracle (NASDAQ:ORCL)

Berkshire Hathaway (NYSE:BRK.A) (NYSE:BRK.B)

Apple (NASDAQ:AAPL)

Microsoft (NASDAQ:MSFT)

Charter Communications (NYSE:CTR)

Apple continues to be a David Einhorn top pick and represents 14% of his long book. He's been long for a long time in addition to successfully trading the position. If you're an Apple long he's a guy worth checking on.

Berkshire Hathaway is the top position of Sequoia Fund. They have recently blemished their track record with the Valeant debacle and the Berkshire position has been maintained for a long time. It is actually fairly small given their historic position. It represents about 8% of the long book after Valeant cured them of an appetite for huge bets.

Chris Hohn's TCI Fund is betting big on Charter Communications with a 38% position according to the 13-F. TCI is London based however and they do a lot of European investments, only U.S. listed positions are revealed on the 13-F, which means the position is likely a much smaller part of the entire portfolio.

Oracle represents a 6.6% position for L.A. based First Pacific Advisors. Oracle is a popular holding among super investors of the value school but positions are generally small compared to some of the jumbo bets we've observed on the other picks.

Microsoft represents 20% of Value Act's U.S. long book. Value Act is an activist investor and they have been on the board of Microsoft for some time. They did very, very well with Microsoft but most recently added to other positions.

You can do a lot worse than buying any of these or checking out Pabrai's interesting Junoon ETF.

Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours.

I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.

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Pabrai And The Shameless Cloning Portfolio - Seeking Alpha

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How to clone your PC hard drive using Macrium Reflect – Windows Central

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Windows Central
How to clone your PC hard drive using Macrium Reflect
Windows Central
Creating a complete backup of your hard drive by cloning it is never a bad idea. Hardware can fail, and it's a pain losing your data. There are also times where you'd like to swap out a hard drive whether in a laptop or a desktop for something ...

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How to clone your PC hard drive using Macrium Reflect - Windows Central

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Reviving woolly mammoths will take more than two years – BBC News

Posted: at 1:19 pm


BBC News
Reviving woolly mammoths will take more than two years
BBC News
In 1996, Dolly the sheep became the first mammal to be cloned from an adult cell. Many different mammalian species have since been cloned, but the elephant is not among them. Cloning research suggests that, just because it is possible to clone one type ...

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Reviving woolly mammoths will take more than two years - BBC News

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The evolution of Clayton Kershaw – ESPN (blog)

Posted: at 1:19 pm

GLENDALE, Ariz. -- High atop the Washington, D.C.-area Gaylord National Harbor Hotel, where all of baseball aroused itself from its brief winter slumber below, the games best pitcher gave a nod to his newest subtle change.

Nothing major, Clayton Kershaw admitted. Just an adjustment to his between-seasons routine, the Los Angeles Dodgers ace said at baseballs winter meetings. Nobody would have known the difference had the question not been asked.

Kershaw denied it was related to the back injury that interrupted his 2016 season. More than anything, he revealed, the alterations were done as an acknowledgement of his nine major league seasons, his 1,760 innings pitched and his approaching 29th birthday on March 19.

The routine has been a little different, but its not drastic changes, which is great, Kershaw said upon reporting to spring training last week. I feel like I am able to still get in the work I need to get in. I just am a little more aware of just pushing through stuff, and things like that, just a little more aware. But I would say, for the most part, not a lot has changed. I feel good.

Locked into every season, every game, every inning and every pitch, Kershaw has worked himself into a baseball giant. He has elevated the art of pitching, and his place at Cooperstown already seems secure. He might be one of the best to ever kick the clay atop the mound, but even he is always tinkering with his formula for greatness.

During his first full season as a major leaguer in 2009, 71 percent of Kershaws pitches were fastballs. Nearly every year since, he has relied on his fastball less, which means his breaking ball usage has gone up. In 2016, his fastball/breaking ball usage was nearly identical at 51 percent to 49 percent.

If people get hits on stuff, you have to change stuff, Kershaw said. Ill stay the same until I start getting hit hard, and then Ill have to make adjustments.

While hitters continuously try to catch up to Kershaw, he always has been able to stay a step ahead to maintain his elite level.

He essentially developed his slider at the major league level after arriving in L.A. as more of a fastball/curveball pitcher. In 2012, Kershaws slider truly arrived and from 2012-13, while throwing it in the 85 mph range, opponents batted .195 against it, with a .334 slugging percentage.

At the start of the 2014 season, though, Kershaw threw his slider harder, at an average of 87.5 mph, according to ESPN Stats & Information. In 2015, he was throwing his slider at 88 mph, and last season he threw it 87.8 mph.

What kind of difference did a harder slider make? In those three seasons (2014-16), opponents hit .157 against the Kershaw slider, with a .232 slugging percentage.

If Kershaw has his slider complementing the rest of his arsenal in 2017, Cy Young consideration figures to be a foregone conclusion.

I think we can all say we have never seen a player like Clayton both physically and mentally, manager Dave Roberts said. But I think there is something to staying ahead of things. But also he just has a way to execute -- and consistently.

Another spontaneous evolution he integrated into his repertoire last season -- refusing to stand still even upon returning from the disabled list -- was a three-quarter sidearm delivery that he had not used since high school. He was inspired to do it after watching new teammate Rich Hill.

I think when we talk about success, you talk about the creativity that guys have and the passion they have for whatever it is they do. It doesnt matter what they do in life, but if you have the creativity and the passion to go out there and do what youre doing, then youre going to be successful, Hill said. And I think that is the perfect example of a guy like Clayton, who is creative out there on the mound and loves what he does.

So what changes could be in store this year?

Every offseason I say my changeup is getting better, so maybe Ill throw one this year, Kershaw said. It looks great in the bullpen, and then I dont throw it in the game.

Will he really use it?

I dont know. Who knows? Well find out.

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The evolution of Clayton Kershaw - ESPN (blog)

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