Daily Archives: February 14, 2017

The Alliance for Regenerative Medicine Releases Statement in Response to National Academies Report on Human … – Benzinga

Posted: February 14, 2017 at 11:49 pm

WASHINGTON, DC--(Marketwired - Feb 14, 2017) - The National Academies of Sciences, Engineering and Medicine today issued a report that examines the scientific, clinical, ethical, legal and social implications of human genome editing. The Alliance for Regenerative Medicine (ARM) believes that genomic medicines, including genome editing, hold great promise for the treatment of a multitude of hereditary and acquired diseases where there is presently no effective treatment available.

ARM issued the following statement:

The Alliance for Regenerative Medicine (ARM) applauds the National Academies of Sciences, Engineering and Medicine for its very thorough and thoughtful report on the current scientific, technical, ethical, and policy issues relating to human genome editing. We support the need for responsible and ethically appropriate approaches to research and clinical use of these technologies following the seven guiding principles outlined in the report, as well as the need for continued public engagement and dialogue. We also commend the Academies for recognizing the profound impact genome editing will have on the development of a new class of medicines for many patients with presently incurable diseases.

We believe the report's recommendations that "existing regulatory infrastructure and processes for reviewing and evaluating somatic gene therapy to treat or prevent disease and disability" are sensible and will help create a safe path toward eventual clinical adoption and regulatory approval of therapeutics based on somatic cell genome editing.

In addition, we note the report's recommendations on heritable germline genome editing and the strict criteria to be met before ever considering clinical study. ARM will continue to monitor developments related to these applications, but until safety is proven and the risks associated with long-term consequences, both intended and unintended, are fully evaluated, we will remain solely focused on realizing the full therapeutic potential of somatic cell genome editing. Further, we must be satisfied that all relevant moral and ethical issues have been addressed and that a broad societal consensus exists as to the benefits and risks associated with editing the germline.

ARM believes that advances in the field of gene therapy, including somatic cell genome editing, have the potential to profoundly and positively impact the practice of medicine for currently incurable genetic diseases, such as muscular dystrophy, sickle cell disease (SCD), cystic fibrosis, hemophilia, adrenoleukodystrophy (ALD), Alpha-1 Antitrypsis Deficiency (AATD), and Transthyretin Amyloidosis (ATTR), as well as acquired diseases such as cancer, certain forms of heart disease, HIV, Hepatitis B virus, and other infectious diseases.

It is estimated that 30 million Americans, or 1 in every 10 people, are afflicted with one of the approximately 7,000 rare diseases. Two thirds of those affected are children. The National Organization for Rare Disorders (NORD) estimates that for 95 percent of these diseases no FDA-approved treatment currently exists,(1) and the few treatments that are available generally address the symptoms and not the underlying genetic cause of the disease. As a result, these treatments must be administered for the duration of a patient's life. In contrast, genome editing offers the very real potential to bring hope to rare disease patients through development of a broad range of new technologies to precisely target and modify the genetic material of a patient's cells. By removing, repairing, or replacing a defective gene or genes, these therapies hold the promise of potentially curing a broad range of diseases with a single treatment.

Similarly, in diseases such as cancer, HIV, and beta-thalessemia, genome editing is being employed to modify T cells and hematopoietic stem cells ex-vivo. The modified cells are then delivered to the patient to treat and potentially cure the underlying disease. These programs build upon early successes and several advanced programs based on somatic cell gene replacement therapies.

According to a recent white paper titled, "Therapeutic Gene Editing," published by the American Society of Gene & Cell Therapy (ASGCT), "the successful development of effective treatments based on genome editing could shift today's approach from a lifetime of symptom management for hereditary diseases to tomorrow's ideal of making a one-time curative repair or change to an individual's affected gene. The goal is a long lasting, perhaps life-long effect that minimizes or even eliminates disease."(2) Diseases involving multiple genes may also be treatable if the therapy can alter specific genes affecting the course of the disease.

ARM represents a number of companies and research institutions that use various gene therapy and genome editing technology platforms, including CRISPR/Cas9, zinc finger nucleases (ZFNs), homing endonucleases, vector-driven homologous recombination, transcription activator-like effector-based nucleases (TALEN) and meganucleases, amongst others to design therapeutics that address a wide range of, hereditary and acquired diseases.

About The Alliance for Regenerative Medicine

The Alliance for Regenerative Medicine (ARM) is an international multi-stakeholder advocacy organization that promotes legislative, regulatory and reimbursement initiatives necessary to facilitate access to life-giving advances in regenerative medicine worldwide. ARM also works to increase public understanding of the field and its potential to transform human healthcare, providing business development and investor outreach services to support the growth of its member companies and research organizations. Prior to the formation of ARM in 2009, there was no advocacy organization operating in Washington, D.C. to specifically represent the interests of the companies, research institutions, investors and patient groups that comprise the entire regenerative medicine community. Today, ARM has more than 250 members and is the leading global advocacy organization in this field. To learn more about ARM or to become a member, visit http://www.alliancerm.org.

1. National Organization for Rare Disorders (2015). NORD developing 20 natural history studies for 20 rare diseases (Press Release). https://rarediseases.org/fda-awards-nord-250000-grant-to-support-the-development-of-20-natural-history-studies-for-rare- disease-research/.

2. American Society of Gene & Cell Therapy (2016). Therapeutic Gene Editing: An American Society of Gene & Cell Therapy White Paper. http://www.asgct.org/UserFiles/file/TherapeuticGeneEditingWP_Nov21_v1.pdf.

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Type 1 diabetes: Reprogramming liver cells may lead to new treatments – Medical News Today

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Researchers have discovered a way to reprogram mouse liver cells into precursor pancreatic cells by changing the expression of a single gene. They suggest that the finding is an important step toward showing that reprogramming liver cells might offer a way forward for the treatment of type 1 diabetes in humans.

The team - led by researchers from the Max Delbrck Center for Molecular Medicine in Berlin, Germany - reports the study in the journal Nature Communications.

Diabetes is a chronic disease that develops either when the body cannot make enough insulin, or when it cannot effectively use the insulin that it does make. Insulin is a hormone that regulates blood sugar, or glucose, and it helps to convert glucose from food into energy for cells.

Uncontrolled diabetes leads to high blood sugar, or hyperglycemia, which over time causes serious damage to many parts of the body, including the heart, blood vessels, nerves, eyes, and kidneys.

In the United States, an estimated 29.1 million people have diabetes, including 8.1 million who are undiagnosed.

The most common type of diabetes is type 2, in which the body cannot use insulin effectively. Type 1 diabetes, in which the body does not make enough insulin, accounts for around 5 percent of diabetes cases in adults.

The new study is likely to interest researchers developing treatments for type 1 diabetes. In people with type 1 diabetes, the immune system attacks the insulin-producing beta cells of the pancreas.

Researchers in regenerative medicine are exploring ways to generate new populations of pancreatic beta cells as a possible avenue for the treatment of type 1 diabetes.

Fast facts about type 1 diabetes

Learn more about type 1 diabetes

The new study concerns a method called cell reprogramming, in which it is possible to convert one type of cell into another type of cell, by tweaking genes.

An obvious source of cells for reprogramming into insulin-producing beta cells might be other types of cell in the pancreas.

In their study paper, the researchers mention other research that shows such pancreatic cells display a high degree of the necessary "cellular plasticity."

However, the researchers chose to focus on liver cells because, from a clinical perspective, they offer important advantages over pancreatic cells; for example, they are more accessible and abundant.

They also cite studies that have partially corrected hyperglycemia in diabetic mice by reprogramming liver cells into pancreatic beta cells.

The new study shows how just by changing the expression of a single gene called TGIF2, the team was able to coax mouse liver cells to take on a less specialized state and then stimulate them to develop into cells with pancreatic features.

When the researchers transplanted the modified cells into diabetic mice, the animals' blood sugar levels improved, suggesting the cells were behaving in a way similar to pancreatic beta cells.

The researchers identified TGIF2 (Three-Amino-acid-Loop-Extension homeobox TG-interacting factor 2) by running gene expression profiling tests on immature liver and pancreas cells isolated from mouse embryos as the cells differentiated toward their particular cell fates.

They found that at a particular differentiation branchpoint, the expression of TGIF2 changes in opposite directions as the cells commit to either liver or pancreatic fates.

The authors note that their study shows that "TGIF2 is a developmental regulator of pancreas versus liver fate decision," and when expressed in adult mouse liver cells, it suppresses the transcription program for liver cells and induces a subset of pancreatic genes.

There is still a lot of work to do to investigate whether the results with mice translate to humans. The team has already started working on human liver cells.

"There are differences between mice and humans, which we still have to overcome. But we are well on the path to developing a 'proof of concept' for future therapies."

Senior author Dr. Francesca M. Spagnoli, Max Delbrck Center

Learn how type 1 diabetes kills some insulin-producing cells but not others.

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‘Pirates of Penzance’ is comic gold – Mount Desert Islander

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Mount Desert Islander
'Pirates of Penzance' is comic gold
Mount Desert Islander
So, when this most recent snow has presumably cleared, get to The Grand and abandoned yourself to some very piratical, if politically incorrect, fun. Performances at The Grand are on Friday, Feb. 17, at 7 p.m., and Saturday and Sunday, Feb. 18 and 19 ...

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SB17: Clarifying student freedoms – Hopkinsville Kentucky New Era

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Lawmakers often avoid new legislation because they dont want to overregulate or create unintended consequences. Hence the adage, Nothing moves in government unless its pushed.

In other states, we have seen speakers uninvited, student-led groups denied the right to meet, and individuals mocked by faculty and peers because of their politically incorrect opinions.

Last years, California State University President Covino intended to reschedule conservative columnist Ben Shapiros lecture. The politically conservative student group who invited him held the lecture anyway. They were met with angry protestors blocking entry to the building. Students who arrived early enough to get in before protestors arrived were told by campus security to leave by sneaking out the back door.

The campus response? A safe space debriefing was held in the Student Union; not for the beleaguered conservatives, but for the liberals who felt unsafe having a conservative speaker on campus.

I disagree on many points with Milo Yiannopoulis, but I do agree that political correctness is, like the title of his new book, Dangerous. Students at UC Berkeley rioted recently, protesting Yiannopoulos talk on the dangers of political correctness. They broke windows, lit fires and caused over $100,000 in damages, essentially proving his premise.

Granted, the University of Kentucky is not Berkeley but the Foundation for Individual Rights in Education gave UK a yellow rating, citing concerns about the Universitys policy limiting free speech to specified zones on campus.

Schools should be places where truth is sought, intellect is developed, and ideas are tested and refined. Instead, students freedom of thought and speech are in serious peril.

Its true, the most egregious examples occur not in Kentucky but in other states- you know, the ones on the coasts.

Mark Twain quipped I want to be in Kentucky when the end of the world comes, because they are always 20 years behind.

But Kentucky might not be 20 years behind on this. It was in Kentucky, after all, that in 2006 Russell County High School Senior Megan Chapman was prevented from praying at her graduation.

And in 2015 that the Paintsville elementary Christmas program was censored, protecting students from the sinister A Charlie Browns Christmas. Thank goodness for the bravery of the administration in sparing those students from the terrible fate of the millions who have had to hear about the meaning of Christmas while watching this treasured classic.

Senator Juliann Carroll said in last years hearing on Kentucky Senate Bill 17, The Student Free Speech and Religious Liberty Bill, that people are so afraid of crossing over the line that they arent getting anywhere near it.

Passage of viewpoint neutral SB17 would make the appropriate line more clear for administrators, teachers, parents and students. Last Friday, the Kentucky Senate thought it was time to push or perhaps push back and protect Kentucky students. Now it is time for the House to act.

After all, what happens in California doesnt stay in California.

(JOYCEOSTRANDER is a policy analyst for the Family Foundation of Kentucky. She does not have a listed email address, but may be contacted through her executive director, Kent Ostrander at kent@kentuckyfamily.org.)

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What Is Censorship – Censorship | Laws.com

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What is Censorship? Censorship is the act of altering, adjusting, editing, or banning of media resulting from the presumption that its content is perceived to be objectionable, incendiary, illicit, or immoral by the presiding governmental body of a specific country or nation or a private institution. The ideology and methodology of Censorship varies greatly on both domestic and international levels, as well as public and private institutions. Governmental Censorship

Governmental Censorship takes place in the event that the content, subject matter, or intent latent within an individual form of media is considered to exist in contrast with preexisting statutory regulations and legislation. In many cases, the censorship of media will be analogous with corollary laws in existence. For example, in countries or nations in which specific actions or activities are prohibited, media containing that nature of presumed illegal subject matter may be subject to Censorship. However, the mere mention of such subject matter will not always result in censorship; the following methods of classification are typically enacted with regard to a governmentally-instituted statutory Censorship: Censorship within the Public Sector The public sector is defined as any setting in which individuals of all ages inhabit that comply with legal statutes of accepted morality and proper behavior; this differs by locale the nature of the public sector is defined with regard to the nature of the respective form of media and its adherence to legislation: The Federal Communications Commission (FCC) sanctioned by the federal government of the United States in order to regulate the activity taking place in the public setting-based media Censorship and Intent With regard to Censorship, intent is legally defined as the intended result for which one hopes as a result of their participation in the release or authorship of media; typically, proponents for individual censorship will be required to prove that the intent latent within the media in question was enacted knowingly and deliberately in any lack of adherence to legislation Censorship and Privacy

With Regard to censorship, privacy is a state in which an individual is free to act according to their respective discretion with regard to legal or lawful behavior; however, regardless of the private sector, the adherence to legislation and legality is required Private and Institutional Censorship

Private institutions retain the right to censor media which they may find objectionable; this is due to the fact that the participants in private or independent institutions are defined as willing participants. As a result, upon joining or participating in a private institution, the individuals concede to adhere to applicable regulations:

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Censorship does both harm, good – waterloo.k12.ia.us

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Censorship is the act or practice of suppressing the speech or public communication which is considered objectionable, harmful and sensitive, by a government, media outlet or other controlling bodies. This public content is censored for many reasons that the active bodies believe are immoral. Some reasons include: controlling obscenities, pornography, hate speeches, protecting young children, to promote or restrict political or religious views or even to protect the national security of a country.

Types of Censorship:

Almost everything at some point could be placed underneath a category of censorship. Depending on where people[E1] are located and who or what is going on in your nation or even community, your public media on the television, Internet, radio, music, movies and books could be censored. There are dozens of different forms of censorship implemented everyday, including all the following:

Moral Censorship- the removal of materials that is considered obscene or morally unacceptable. For example, pornography is usually censored from the public and even prosecuted if it involves young minors.

Political Censorship- This is a form of censorship by the government that occurs when information is [E2]withhold from their citizens[E3], mostly used to prevent hateful expressions.

Book Censorship- The censorship of novels is either implicated nationally or by state[E4]. So, if a community finds a book to be inappropriate, they can have the book removed from public and school libraries. Such books include The Harry Potter series, Animal Farm, the Goosebumps series, The Perks of Being a Wallflower, and To Kill A Mockingbird[E5].

Films- All movies released for public viewing in theaters are censored in some way or another. The usual censored items include pornography and obscenities, up to a certain age. Other movies are censored due to racial or political correctness.

Music- Moral authorities are determined to find what behavior is acceptable for individuals in todays society. Most cases of musical censorship involve lyrics which deal with drugs, violence and sexual topics.

Internet- The extent of Internet censorship varies from country to country. Many countries, like the Untied States have little to no Internet censorship, while others limit basic new information from their citizens. Many times the Internet[E6] in these countries will be censored after elections, protests and riots.

Effects of Censorship

Many people agree that some things need to be censored. While others are outraged at the thought of any individuals work being censored. Many times things that are being viewed or heard by larger masses of people should be censored for the sole fact that you do not know who is in that group of people.

I think it is fine to censor T.V. because it is something that all the public can use, including kids, and parents cant always control what shows come up, grade Kalie Jurries said.

Exposing underage children to inappropriate and vulgar content can have negative effects on a child. Adults have a much easier time choosing what to watch, and are able to work around inappropriate work.

I filter[E7] by choosing not to watch television at certain times or certain channels, librarian Joanne Willis said.

Their ways of thinking and understanding are not always able to understand adult content.

While many believe television should be censored, many feel the complete opposite about the Internet and printable material like books.

No, I do not think the Internet should be censored. If[E8] people cant handle the content of the Internet[E9], maybe they should not be on it. Everyone on the Internet should be old enough to deal with those things, Jurries said.

The Internet is a very useful tool in todays society, and just like any other great tools in life, there will be people who abuse it.

Access at certain age levels or times should be controlled. Example[E10]: access to sexually explicit internet materials should not be allowed at the high school level or in an office environment where it would/could be offensive to coworkers, said Willis.

Pros and Cons of Censorship

Censorship is all about perspective. Whether you are the over the top strict parent or the care free, young kid who wants to know everyone. Censorship will always be a heated debate, both sides have their pros and cons. Religious conflicts often times can be avoided by the censorship of certain material that people deem insulting or offensive. Censorship can be used to prevent politically motivated propaganda. Plagiarism can be prevented. It prevents companies from spreading inaccurate or exaggerated claims about their products or other companies.

Freedom of speech is compromised. Media giants can push their agendas under the censorship. it hinders upon the freedom of the press. It shelters people from things that they need to know about. Censorship in books, plays, and movies may effect the overall feeling and meaning of the writing.

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Despite Censorship Row, a Show Connecting Immigrant Rights and Police Brutality Goes On – Hyperallergic

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View of Scott Daniel Williamss Storefront Sign for the Ungovernable City (2016) partially installed at the Loisaida Center (image courtesy the artist)

Ifyou visitthe Loisaida Centerin the next month, the firstthing youll notice is the sound of running water and voices some in English, some in Spanish telling stories about the Rio Grande river. Then youll see the rest of El Paso-based artist Zeke Peas collaboration with local musicianEureka The Butcher,River Border, a large graphite drawing on cloth that maps the stretch of the MexicoUS border where a military wallruns along the banks of the Rio Grande in the El Paso del Norte region. The combined effect of the Peas drawing and Eurekas recordingsis powerfully evocative, transporting the visitor to the rivers edge.

The next sound you mightve heard would have come from Albuquerque-based artistScott Daniel Williamss interactive sculpture, Storefront Sign for the Ungovernable City which, behind a sign that reads Police Not Welcome, can be toggledby pulling a chainto simultaneously play a recording of Ornette Colemans The Artist in America and audio ofthe killing ofJames Boyd byAlbuquerque Police Department officers in 2014. That workwas originally installed near Loisaidas main entrance by the curators ofFuture Now // Futura Ahora, Atomic Culture(the duo of Matthew and Malinda Galindo), but was removed on February 3, the day before the exhibitions opening. The decision, taken unilaterally by one of Loisaidas directors, was spurred by a fear that the centers CEO, Raul Russi a former Buffalo police officer who was injured in the line of duty would object to the work.This act of censorship repeatedly threatened to undo Atomic Culturesvital exhibition.

Its a very difficult situation for us as artists because this is a community center, and its a Latin Americancommunity center specifically, thats done a lot of really, really incredible work and we want to stand as allies with the center, Williams told Hyperallergic. It was a difficult decision to even take any sort of stand, but at the same time I think we [the artists in the show]feel like thats where we have to start. If were going to talk about expression and social justice we have to start at home, in these places where we should all be most accountable.

Russi who only became aware of the situation after Williams had issued a public statement and protested the exhibition opening, and negotiations between the artist, curators, and Loisaida directors had reached an impasse finally saw Storefront Sign for the Ungovernable City and the rest ofFuture Now // Futura Ahoraduring a visit to the center on Saturday. Today, he releaseda public statement about and apologyfor the works removal, paving the way for the reinstallation of Williamss work in a different space at Loisaida tomorrow.

Unfortunately, our team jumped to the wrong conclusion that I would object to the exhibition of one of the pieces without consulting with me in advance, Russis statement reads. I had the opportunity over the weekend to have a dialogue with the Atomic Culture organizers, to clarify all of this and to offer my apologies on behalf of Loisaida, Inc. As CEO, I let Atomic Culture know that the piece can be part of their ongoing exhibit.

Indeed, Williamss work seems especially relevant for an exhibition about social justice at a community center that represents a historically over-policed community and is located directly next to a major NYPDstation. Add to this the fact that all the featured artists in Future Now // Futura Ahoraare based in the southwestern United States, an area poised to become an intensified zoneof activity for the USs militarized border patrols under President Trump, and the show takes on an added sense of urgency.

In addition to Williamss piece, several other works in the exhibition condemn the excessive use of force and systemic abuses of agents paid to uphold the law. For instance, the mural On Both Sides of the Border Women Are Still Being Murdered (2016) a collaboration between Albuquerque-based artist Nani Chacon and author Tanaya Winder highlights the vulnerability of women in both Mexico and the US. And Peas aforementioned map of the Rio Grande and border wall includes a drawing of a threatening US Border Control vehicle alongside the words: You have the right to remain silent.In one of the exhibitions main rooms, a row of small, vintage-looking cell phones emits poetry and displays compass faces that seem to point the viewer north. The work, Transborder Immigrant Tool, is a safety systemdeveloped by San Diego-based artistsRicardo Dominguez and Brett Stalbaumto help disoriented travelers in any desert setting to find their way. The program offers tips for desert survival in the form of poetry recited in several different languages, and logs the coordinatesof known water caches, offering a vital tool for people crossing, for instance, the MexicoUS border in southern California, where the artists developed and tested it between 2009 and 2012.

Atomic Culturehas brought together a powerful group of artists from the southwestern US, many of whom are making work at theconfluence of art and activism, and most of whom are too rarely exhibitedin New York. Fortunately, Loisaida has rectifiedthe earliercensorship of one work and, in doing so, avoided jeopardizing the telling of all the other featured artistsimportant stories. Indeed, the reinstallation of Williamss piece will provide a crucial link between the issues of migrant safety and anti-immigrant infrastructure along the MexicoUS border that many of these artists are addressing. Police brutality often targets the most vulnerable residents in the country, and some US cities situated near the Mexican border are particularly prone to this type of institutionalized violence. The fact that many of the artists here are from Albuquerque is particularly poignant, since the citys police department is under investigation for use of force by the Department of Justice.Future Now // Futura Ahora is a testament to the works artists make not only to cope with such conditions, but to combat them.

Future Now // Futura Ahora continues at the Loisaida Center (710 East 9th Street, Lower East Side, Manhattan) through March 18.

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Nick Cannon accuses NBC of censorship, leaves ‘America’s Got Talent’ after 8 years – Washington Times

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Nick Cannon announced his abrupt resignation from NBCs America's Got Talent Monday, accusing the network of trampling on his free speech rights and trying to censor him following a racial joke he made on his recent Showtime stand-up special.

The comedian announced his unexpected exit on Facebook, saying he was deeply saddened about being threatened with termination after his controversial joke on Stand Up, Dont Shoot reportedly irked NBC executives.

I find myself in a dark place having to make a decision that I wish I didnt have to, but as a man, an artist, and a voice for my community I will not be silenced, controlled or treated like a piece of property, Mr. Cannon wrote. There is no amount of money worth my dignity or my integrity.

My moral principles will easily walk away from the millions of dollars they hang over my head, he added. Its never been about the money for me, what is difficult to walk away from is the fans, the people who love me on the show. This hurts tremendously.

Mr. Cannons resignation came after rumors swirled that NBC executives were considering terminating his contract following a racial joke he made about America's Got Talent on his comedy special that aired on Showtime Friday night.

Sometimes I wish I could say the stuff that I really want to say, Mr. Cannon said on stage, according to a clip posted by TMZ. Cause yall see my face on America's Got Talent? Like, This next crazy motherfer coming to the stage gonna be juggling blindfolded with knives and shit, so nas be careful! But I cant say that. I cant talk like that. Cause that would mess up the white money.

Sources familiar with the situation told TMZ that NBC executives thought Mr. Cannon was disparaging the network. Sources said NBC considered terminating Mr. Cannons contract but ultimately decided to keep him after determining the joke was a passing comment, TMZ reported.

Still, Mr. Cannon said his decision to resign was based on a moral duty to stand up for what he believes is right.

I have fought many battles in my career and have never been afraid to go up against the system. I have mulled over my process for days and felt it was best to once again speak my mind about an unjust infrastructure that treat talent like they own them, he wrote Monday. So I wish AGT and NBC the best in its upcoming season but I can not see myself returning. As of lately I have even questioned if I want to even be apart of an industry who ultimately treats artists in this manner.

Production on season 12 of America's Got Talent is scheduled to begin next month. A replacement for Mr. Cannon, who served as the host since 2009, has not been named.

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Unwilling to Reason: Why Censorship is the Wrong Answer – Daily Nexus

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As of late, a wave of censorship has swept over this campus. Those who would silence the free speech of UCSB students are not authorities but private individuals. The College Republicans have set up signs around campus in an effort to advertise for their Ben Shapiro event on the topic of Black Lives Matter. They have followed all of the correct procedure. They have been met with vandalism. Their wood signs have been repeatedly painted over and their fliers ripped from sight.

Those who have repeatedly defaced the College Republicans signs are unwilling to reason. This would be obvious to any outsider looking in to the enclosed environment of this UC campus. In a place where one-sided classes on political issues are taught as fact, it is a wonder that there are any students at the university who would challenge the doctrines imposed on them at all.

Art by Sierra Deak / Daily Nexus

When knowledge is transmitted in such a way as it is in the university system, there is little hope for dialogue. I hear those on the left clamoring for a national dialogue, yet they offer nothing but the destruction of property, both private and public. Observe the force employed by the individuals at UC Berkeley in response to the Milo Yiannopoulos event scheduled there. And now, in a small act of what is perhaps imitation of their more violent comrades at Berkeley, leftists of UC Santa Barbara have destroyed the signs advertising the Ben Shapiro event. Nothing else could be expected from those who consider speech violence.

To equivocate speech and violence is to obliterate the distinction between reason and force. Free speech is a principle of this liberal society for one reason: so that thinking individuals may partake in a discussion of their ideas with other individuals. It is the political prerequisite to freedom of the mind that is, the freedom to reason. As humans are thinking, rational animals, such an ability as reasoning is essential for our existence within a society.

Reason is exactly the means that humans use to avoid predation on each other. In the personal sphere, reasoning is absolutely essential. Consider sex, the most personal and intimate of all human relations. Any good persons intuition regarding sex would prescribe a consensual basis for it. Consent requires a state of consciousness and agency. Such a state is the state of reason. Reason demands conscious awareness and the ability to exercise ones volitional faculties, and so it is the heart of consent. When consent is not given by all parties involved, when force is substituted for reason, the interaction becomes rape or sexual assault. Voluntary, willful consent is required in the realm of sex. It is considered most vital in this context but abandoned in others.

If the free expression of our ideas is not protected by a just government, then where is justice in our law?

The person who forces another person to be his or her friend has nothing to offer. Friends help each other. Friends do good to their friends. This is common sense. If force is used, real value and worth is absent. Just as this applies to friendship, so it applies to politics. Particularly, freedom of speech. It is a truth that no one wants something that must be forced on them. Furthermore, no one wants what is theirs to be taken away by force. Ideas are the most intimate kind of possession. They make up our minds and ourselves. If the free expression of our ideas is not protected by a just government, then where is justice in our law? Are we to apply principles of freedom to one area of our life and not the other? I would say the freedom to speak and not necessarily to be heard is more valuable than a friendship. What friendship could survive without being grounded on a firm slab of truth? What truth can be arrived at except by the free expression and exploration of ideas?

When we apply the principle of reason to economic and political relationships, we get a free market. When we apply it to academics, we should get a free market of ideas. If there is any place in the nation to glorify free speech, it should be the university. Knowledge is the business of the university. Knowledge requires truth. Truth is not easy to obtain. To obtain truth, there is only one principle that can be brought to bear. This is reason and its corollary, freedom of speech.

I am an individualist, so I do not believe everyone on the left condones the savage actions of those students who defaced the College Republicans signs. I do not believe even the majority of those on the left are gripped by a fundamentally irrational Marxist ideology that denies the premises of reason and freedom. In the coming weeks, there will be events which promote unpopular ideas. If for no other reason than to affirm that it is okay to hold an unpopular idea, these events are a blessing. With regards to the administration of this university, the vandals who ruined the College Republicans signs should be found and punished. Their punishment should not be minimal. They should serve as an example so the university can assure its students that freedom of speech will be protected.

Connor Pardini believes in the right to hold an opinion, popular or not.

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NEW: Three face human-trafficking charges; Boynton woman, 19, targeted – Palm Beach Post

Posted: at 11:41 pm

BOYNTON BEACH

Three South Florida menremained in custody early Tuesday after their arrests last week on human-trafficking charges after police alleged a 19-year-old woman was kidnapped from a Boynton Beach home.

Authorities say Jackson Poinvil, 21, of West Palm Beach and Jimmy Edmond, 26, and Christopher Thomas, 22, of Port St. Lucie intended to put an ad on a social-media site for the womans sexual services.

I was in fear of my life, city police said the woman told them during a taped interview.

All three men are facing charges of kidnapping with the intent of human trafficking. In addition, Edmond faces burglary with assault and heroin and cocaine possession charges and is being held on $462,000 bail. Thomas also faces burglary with assault charges, and his bail is set at $450,000. Poinvil also is charged with carrying a concealed and unlicensed firearm and is being held on $350,000 bail.

The alleged kidnapping took place just before 12:30 a.m. Thursday at a home onNorthwest Fourth Street, north of Boynton Beach Boulevard and west of Seacrest Boulevard near Sara Sims Park. A witness told police that two of the men pulled out guns upon entering the home. One pointed a light-colored revolver at the womans stomach, grabbed her by the back of the head and forced her to leave, police said.

The woman later appeared on the Backpage.com website advertising sexual relationship.

An undercover detective spoke to the woman by telephone and arranged to meet her at a Boynton Beach motel, offering to pay $200. Police monitored the suspects vehicle as a detective met the woman in the lobby of the hotel.

She had bruising and appeared to have been crying, police said.

Edmond, Thomas and Poinvil were taking into custody without incident. Poinvil allegedly told officers he and the other men had gone to the Boynton Beach home to pimp the woman out.

Edmond were later found to have crack cocaine and heroin in his possession, the police report said.

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NEW: Three face human-trafficking charges; Boynton woman, 19, targeted - Palm Beach Post

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