Daily Archives: February 7, 2017

Murdered jogger’s family pushing for enhanced DNA testing – myfox8.com

Posted: February 7, 2017 at 7:47 am

Murdered jogger's family pushing for enhanced DNA testing
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Officials say Lewis confessed, providing detailed incriminating statements about the crime. His DNA, obtained through a voluntary cheek swab, matched that found under Vetrano's nails, on her phone, and on her back. If convicted, he faces 25 years to ...
Police: DNA leads to arrest in strangling of NYC joggerUSA TODAY
Suspect's DNA match to jogger lead to arrest: CopsFox5NY
Howard Beach Jogger 'Helped Us Identify' Her Killer by Fighting Back: NYPDDNAinfo
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Murdered jogger's family pushing for enhanced DNA testing - myfox8.com

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Injection could permanently lower cholesterol by changing DNA – New Scientist

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High cholesterol isnt good for us

CMEABG-UCBL-Chapon/Phanie/Science Photo Library

By Michael Le Page

A one-off injection could one day lower your cholesterol levels for the rest of your life.

People born with natural mutations that disable a specific gene have a lower risk of heart disease, with no apparent side effects. Now a single injection has successfully disabled this same gene in animal tests for the first time.

This potential treatment would involve permanently altering the DNA inside some of the cells of a persons body, so doctors will have to be sure it is safe before trying it in people. But the benefits could be enormous. In theory, it could help millions live longer and healthier lives.

The results of the animal study were described by Lorenz Mayr, of pharmaceutical firm AstraZeneca, at a genomics meeting in London on 1 February. Mayr, who leads the companys research into a DNA editing technique called CRISPR, wouldnt say whether AstraZeneca plans to pursue this approach, but he was clearly excited as he presented the findings.

The idea would be to do it as a one-off, he later told New Scientist. It should be permanent.

Heart attacks and strokes kill a quarter of people living in rich nations, and high levels of bad LDL cholesterol in the blood greatly increases the risk. For this reason, millions of people now take statins to lower their LDL cholesterol levels. While statins undoubtedly extend the lives of many people, some experience side effects such as muscle pain, leading drug companies to look for alternative treatments.

In 2005, it was discovered that a few people naturally have very low cholesterol levels, thanks to mutations that prevent their livers from making a protein called PCSK9. They have a lower incidence of cardiovascular disease and no apparent side effects whatsoever, says Gilles Lambert at the University of Reunion Island, who studies PCSK9.

The PCSK9 protein normally circulates in the blood, where it degrades a protein found on the surface of blood vessels. This second protein removes LDL cholesterol from the blood: the faster it is degraded by PCSK9, the higher a persons cholesterol levels. But people who lack PCSK9 due to genetic mutations have more of this LDL-removal protein, and therefore less cholesterol in their blood.

To mimic this effect, two companies have developed approved antibodies that remove the PCSK9 protein from the blood. These are very effective at lowering cholesterol and no serious side effects have been reported so far, Lambert says. It is yet to be shown if they reduce the risk of cardiovascular disease, but the first trial results are due to be announced in March.

However, the antibody drugs are extremely expensive and need to be injected every two to four weeks, so even if the antibodies work as well as hoped, they cannot be dished out to millions like statins. All attempts to develop conventional drugs to block PCSK9 have failed.

But gene editing provides a radical alternative. Using the CRISPR technique, the team at AstraZeneca have disabled human versions of the PCSK9 gene in mice.

They did this by injecting the CRISPR Cas 9 protein and a guiding RNA sequence into the animals. The RNA guide helps the Cas9 protein bind to a specific site in the gene. It then cuts the gene at that point, and when the break is repaired, errors that disable the gene are likely to be introduced.

There was an even bigger fall in cholesterol levels in the mice given the CRISPR treatment than in those injected with the antibody drugs.

This gene editing approach would be a closer mimic of what happens in people born with PCSK9-disabling mutations than injecting antibodies, says pharmacologist Patricia McGettigan of Queen Mary University of London, who has looked at the safety of PCSK9 therapies. That might actually be really productive, she says.

The big worry about using gene editing to alter DNA inside the body is that it could also cause unintended off-target mutations. In the worst case, these could turn cells cancerous.

Mayr says the team has tested for off-target effects in 26 different tissues in the mice, and that the results will be published soon. Its very promising in terms of safety, he told New Scientist.

Whats more, the CRISPR method is constantly being improved. Other teams have developed modified versions of the CRISPR protein that are so precise off-target effects occur no more often than natural mutations in cells. Even so, Lambert thinks human trials are at least a decade away. For now its very far-fetched, he says.

An alternative approach that should have fewer off-target effects would be to use modified forms of the CRISPR protein to switch off the PCSK9 gene without altering its DNA. Instead of changing the genome, this kind of editing targets the epigenome instead the chemical tags added to DNA that influence how active particular genes are.

Many think epigenome editing will prove more useful than conventional genome editing for treating diseases. I think the future is CRISPR 3.0 and 4.0, Mayr says, referring to epigenome editing.

Who are you: New in-home DNA testing unlocks family secrets – wtkr.com

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Who are you: New in-home DNA testing unlocks family secrets
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NORFOLK, Va. - We all come from somewhere in this great big world. But, how many of us really know just where that "somewhere" is? For my mother's side of the family, it's Italy and France. Growing up, there was always great cooking in our home. And ...

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Genomes in flux: New study reveals hidden dynamics of bird and … – Phys.Org

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February 6, 2017 Credit: NIH

Evolution is often thought of as a gradual remodeling of the genome, the genetic blueprints for building an organism. But in some instance it might be more appropriate to call it an overhaul. Over the past 100 million years, the human lineage has lost one-fifth of its DNA, while an even greater amount was added, report scientists at the University of Utah School of Medicine. Until now, the extent to which our genome has expanded and contracted had been underappreciated, masked by its relatively constant size over evolutionary time.

Humans aren't the only ones with elastic genomes. A new look at a virtual zoo-full of animals, from hummingbirds to bats to elephants, suggests that most vertebrate genomes have the same accordion-like properties.

"I didn't expect this at all," says the study's senior author Cdric Feschotte, Ph.D., professor of human genetics. "The dynamic nature of these genomes had remained hidden because of the remarkable balance between gain and loss."

Previous research had shown that genome sizes vary widely across different species of insects or plants, a telltale sign of fluctuation. This survey is the first to compare a diverse array of warm-blooded vertebrates, 10 mammals and 24 birds altogether. The study appears online in Proceedings of the National Academies of Sciences (PNAS) during the week of Feb. 6.

Trimming for Takeoff

When evolution repeats itself, there's usually a good reason. For most vertebrates it's not immediately apparent why genome deletions and add-ons typically go hand-in-hand. For flying animals, however, there could be a clue.

Feschotte's foray into the field began five years ago after his research had turned up a paradox. His group and others had found that the genomes of bats were littered with small pieces of DNA, called transposons, that had invaded and copied themselves throughout the flying mammals' genetic material. In particular, this massive transposon amplification had expanded the genome of a species called the microbat by 460 megabases, more genetic material than there is in a pufferfish. Yet the overall size of the bat's genome had remained relatively small in comparison to other mammals, suggesting that while transposons added new DNA, old DNA must have been removed somehow.

"These data begged the question: where did the old DNA go?" says Feschotte. In order to keep their genomes trim, he reasoned, these animals must have been good at jettisoning DNA.

In order to test the hypothesis, his team needed to quantify something that wasn't there, the amount of DNA lost over many millenia. Feschotte and the study's lead author Aurlie Kapusta, Ph.D., a research associate in human genetics, developed methods to extrapolate the amount of DNA that vanished by comparing genome sizes from present day animals to that of their common ancestors.

As they suspected, the microbat lost more DNA over time - three times as much - than it had gained since its divergence from a mammalian ancestor. This bat's cousin, the megabat, slimmed down its genome even more, losing eight times more than had been added.

The findings were a first clue that mammalian genomes were more dynamic than previously thought. But more than that, the data fit in nicely with an idea that scientists had been bantering around for a while. Animals that fly have smaller genomes. One reason could be that the metabolic cost of powered flight imposes a constraint on genome size.

Indeed, expanding the survey to include the bats' compatriots of the skies: woodpeckers, egrets, hummingbirds, and other birds, showed that the genome dynamcis of the two flying mammal species was more like that of the birds than the land-bound mammals. While most mammals trended toward an equilibrium between the amounts of DNA gained and lost over deep evolutionary time, the bats skewed toward shedding DNA over the same time frame.

The biological factors underlying the differences in genome dynamics observed across species are likely to be complex and remains to be explored. But whether streamlining genome content may have allowed flying animals to get off the ground is an intriguing proposal worth investigating, says Feschotte.

"If you look at small parts of the genome, or only one time point, you don't see how the whole genome landscape has changed over time," says Kapusta. 'You can see so much more when you step back and look at the fuller picture."

The work was supported by the National Institutes of Health, and will publish as "Dynamics of genome size evolution in birds and mammals" in PNAS on Feb. 6, 2017.

Explore further: First genome sequence of Amur leopard highlights the drawback of a meat only diet

More information: Dynamics of genome size evolution in birds and mammals, PNAS, http://www.pnas.org/cgi/doi/10.1073/pnas.1616702114

The first whole genome sequence of the Far Eastern Amur leopard is published in the open access journal Genome Biology, providing new insight into carnivory and how it impacts on genetic diversity and population size.

In rare instances, DNA is known to have jumped from one species to another. If a parasite's DNA jumps to its host's genome, it could leave evidence of that parasitic interaction that could be found millions of years latera ...

(PhysOrg.com) -- Researchers at The University of Texas at Arlington have found the first solid evidence of horizontal DNA transfer, the movement of genetic material among non-mating species, between parasitic invertebrates ...

Researchers from the University of Bristol have uncovered one of the reasons for the evolutionary success of flowering plants.

(Phys.org) It has long been known that birds and bats have small genomes, but the cause was uncertain. Now researchers at the University of New Mexico have shown that the genome shrinks over evolutionary time in species ...

In a contribution to an extraordinary international scientific collaboration the University of Sydney found that genomic 'fossils' of past viral infections are up to thirteen times less common in birds than mammals.

Researchers at the Hebrew University of Jerusalem have discovered a survival strategy that harmful bacteria can use to outsmart the human immune response, resulting in more severe and persistent infections and more effective ...

Researchers at the University of Southampton have developed a new 3D system to study human infection in the laboratory.

To the average plant-eating human, the thought of a plant turning the tables to feast on an animal might seem like a lurid novelty.

Conventional wisdom holds that sharks can't be harvested in a sustainable manner because they are long-lived animals. It takes time for them to reproduce and grow in numbers. But, researchers reporting in Current Biology ...

A grisly method by which bacteria dispatch their distant relatives also creates conditions in which the attackers can thrive, research has found.

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Stanford researchers aim to create global conversations about long, healthy living – Stanford University News

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Over the last century, Americans have added an unprecedented 30 years to their life spans. But most people still rarely think about or plan for the possibility of living until 80, 90, 100 years and beyond.

The Sightlines project at the Center for Longevity is designed to encourage research and discussion into how to optimize well-being as we live longer lives. (Image credit: kali9 / Getty Images)

The Stanford Center on Longevity hopes to ignite a cultural shift in the ways people think about and design longer lives to optimize well-being throughout all stages of a persons life.

This week, the center released the Sightlines project website as part of its goal to stir conversation about what leads to long, healthy living and to encourage more policymakers, entrepreneurs and members of the public to think about ways of redesigning the human life.

Our aim is to help people have a long-term view of their life, said Laura Carstensen, a professor of psychology and director of the Stanford Center on Longevity. Were trying to help people think about living lives as older people much earlier in their lives.

The Sightlines project launched a year ago with a study the center conducted to understand how well Americans are prepared for longer lives. Since then the project has become a flagship of the center.

As part of the study, researchers worked together to identify prevalent indicators of longevity spanning three domains: healthy living, financial security and social engagement. To paint a portrait of Americans standing in these domains, the team compiled data from eight nationally representative surveys and analyzed trends across six age groups in the U.S. population in recent years and among previous cohorts ranging from 10 to 20 years earlier.

The research showed that the biggest negative change over time has been the declining percentage of Americans who are doing well financially. Financial security is less common among Americans in 2014 compared with 2000, especially among the least educated population. In addition, the average debt the Millennials, ages 25 to 34, are facing is five times higher than the debt the same age group carried 15 years ago, according to the research.

Another finding showed that the baby boom generation is less socially engaged than 55- to 64-year-olds in 1995. Baby boomers tend to have weaker ties to family, friends and neighbors, are less likely to be married and are less likely to participate in religious or community activities compared with the same age group of 20 years ago.

When it comes to health, data revealed that more Americans are exercising regularly for the first time in decades. Risky behaviors, like smoking, have also been on a steady decline across every age group.

But the 2016 study was just the starting point for the researchers vision. Over the past year, the team has designed an interactive website showcasing the comprehensive sets of findings from the 2016 study as well as relevant work being done by faculty at Stanford and around the country.

Our hope for developing the website is not just to present our thinking about this topic, but to engage and iterate with people beyond our center as part of an ongoing, evolving discussion focused on preparing Americans for long-lived lives, said Tamara Sims, a research scientist at the Stanford Center on Longevity.

The Sightlines team created interactive data visualizations to provide a deeper look at changes within the American population, not just by age group, but also by gender, ethnicity, education, income, marital status and geographical region where data are available.

The results allow researchers, including Sims, to identify new patterns in the data.

We are offering unique kinds of comparisons, Carstensen said.

For example, recent analyses show that although home ownership has declined for younger generations from 2000 to 2014, young Asian Americans showed no decline in contrast to other ethnic minorities.

Another finding showed that more educated people, who tend to be doing well across most indicators of well-being, are more likely to sit for long stretches of time, which recently emerged as an independent risk factor for health.

The biggest lesson from this next phase of the Sightlines project is that we cant make sweeping generalizations about different generations of Americans or about different domains of well-being, for that matter, Sims said. There are always caveats that need to be considered and further explored.

Carstensen and her team intend for the project to become a connection point for experts around the world who are interested in enhancing human longevity.

In addition to stimulating conversations and informing decisions among influencers and leaders in private and public industry, the projects website can also serve as a research tool by providing scientists with findings and metrics most relevant for designing comparative studies and developing and assessing the effectiveness of interventions.

Carstensen and her team plan on updating their 2016 research in about five years as new survey data is released. The team used data from the U.S. Bureau of Labor Statistics and U.S. Census Bureau; the University of Michigan and the National Institute on Aging; the Centers for Disease Control and Prevention; the Federal Reserve System; and the University of Wisconsin and the National Institute on Aging.

But analyzing existing data limits researchers because some areas that are important to longevity, such as social engagement, are understudied.

So Carstensen, Sims and the Sightlines team intend to work with experts to develop better ways of assessing well-being across the life span and collect more data.

For example, experts have been debating about how to best measure the diet of Americans. Currently, the national benchmark for a healthy diet is measured as eating at least five servings of fruits and vegetables every day.

Is there a gold standard of measuring diet that we should use going forward? Sims said. We are working with faculty affiliates and other experts to tackle such questions.

A next step for the Sightlines project is to develop a comprehensive survey to assess all domains among the same group of people over time and to find answers to questions raised by the original report. Researchers plan to make the survey available online sometime later this year.

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Below the Surface: Study Finds Eczema Damages Confidence – Yahoo Finance

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PISCATAWAY, N.J., Feb. 6, 2017 /PRNewswire/ --Eczema in childhoodis a critical issue, with as many as one out of every three kids suffering from this chronic skin condition. Beyond the constant itching, irritation and distraction caused by this silent skin disease, many children also endure bullying, teasing and a major hit to their self-esteem due to the inflamed, rough patches.

In a new video, PuraCap Pharmaceutical explores the effects of childhood eczema and how parents and kids can find relief.

Fundamental to the disease is impairment to the skin barrier, the protective function that is responsible for the integrity of the skin and the regulation of water loss. Eczema can be triggered especially this time of year by dry, heated indoor environments.

When left untreated, eczema, which may begin during infancy, continues on into the child's teenage years and often lasts into adulthood. In fact, according to a survey by PuraCap Pharmaceutical, six in 10 adults report lower confidence as a result of eczema.

In order to effectively manage eczema symptoms, dermatologists agree that repairing the skin barrier is key to successful treatment; however, 50 percent of consumers are not familiar with skin barrier repair products. In fact, the number one treatment used to combat eczema is over-the-counter moisturizers, which may grant temporary relief, but don't provide lasting hydration or any repair.

EpiCeram Controlled Release Skin Barrier Emulsion can help restore skin to its natural healthy condition. The FDA-approved cream contains all of the essentials for total skin barrier repair to help relieve itching, dryness and redness. Formulated to help keep the skin at a healthy pH of 5, EpiCeram works to repair the skin's barrier and improve the protective properties of the skin.

"Eczema-afflicted skin has fundamental issues with the protective skin barrier," shares Dr. Jessie Cheung, Board-certified Dermatologist in Illinois. "EpiCeram replenishes the lost lipids in the skin with a unique blend of ceramides, cholesterol, and free fatty acids to help rebuild the skin barrier and bind moisture in the skin while keeping irritants out."

With a unique controlled-release technology, EpiCeram delivers 24-hour barrier repair benefits with just twice-daily application.

EpiCeram is only available by prescription. Please consult your physician to find out how it can help manage your eczema.

For more informationor full prescribing information go tohttp://epiceram-us.com

About PuraCap Pharmaceutical LLCPuraCap Pharmaceutical LLC is an emerging, fully integrated pharmaceutical company with expertise in product development, manufacturing and distribution bringing,high quality products & services to their customers. PuraCap's corporate structure supports a two-pronged approach for global growth in the areas of prescription brands and OTC and private label brands (PuraCap Pharmaceutical LLC) as well as prescription generics (PuraCap Laboratories LLC). Go to http://www.puracap.com for more information.

ContactKELZ PR Sheila - 144832@email4pr.com Melissa - 144832@email4pr.com 646.450.5359

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My Life with Plaque Psoriasis and How I’m taking Control – The Killeen Daily Herald

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(BPT) - Whitney was only 19 years old, home from college freshman year, when her mother noticed spots on her arms and elbows. As any parent would be, Whitneys mother was concerned and suggested her daughter see a dermatologist. That visit revealed her diagnosis of moderate-to-severe plaque psoriasis. Little did Whitney know, this would be a lifelong battle that would impact all aspects of her life.

Plaque psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells, causing patches of thick red skin and silvery scales affecting approximately 6 million Americans.1

When I was younger and my psoriasis was flaring, it was very embarrassing and shameful, Whitney said. People didnt understand that I was not contagious. I can remember being turned away by hair stylists who didnt want to cut my hair and being refused a pedicure. My friends and boyfriends didnt understand what was going on with me and I could feel them pulling away at times.

After talking with her doctor about her symptoms, she prescribed a biologic treatment called STELARA (ustekinumab).

I went through some very challenging times with my psoriasis symptoms. Starting treatment with STELARA helped me to take control of my disease and start to create new memories with my family and friends, said Whitney. With clearer skin, I was able to walk down the aisle in a strapless wedding dress, and it was amazing!

Eventually, Whitney would also be diagnosed with psoriatic arthritis, an inflammatory arthritis causing joint pain, stiffness and swelling that affects approximately 30 percent of people with psoriasis.2 STELARA (ustekinumab) also is approved to treat psoriatic arthritis and, over time, Whitneys joint pain and swelling have diminished significantly.

Visit http://www.STELARAINFO.com to learn more about STELARA

WHAT IS STELARA?

STELARA is a prescription medicine approved to treat adults 18 years and older with moderate or severe plaque psoriasis that involves large areas or many areas of their body, who may benefit from taking injections or pills (systemic therapy) or phototherapy (treatment using ultraviolet light alone or with pills).

STELARA is a prescription medicine approved to treat adults 18 years and older with active psoriatic arthritis, either alone or with methotrexate.

STELARA (ustekinumab) works by targeting an underlying cause of plaque psoriasis and psoriatic arthritis an overactive immune system. It blocks two proteins called IL-12 and IL-23 that may play a role in plaque psoriasis and psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

STELARA (ustekinumab) is a prescription medicine that affects your immune system. STELARA can increase your chance of having serious side effects including:

Serious Infections

STELARA may lower your ability to fight infections and may increase your risk of infections. While taking STELARA, some people have serious infections, which may require hospitalization, including tuberculosis (TB), and infections caused by bacteria, fungi, or viruses.

Your doctor should check you for TB before starting STELARA and watch you closely for signs and symptoms of TB during treatment with STELARA.

If your doctor feels that you are at risk for TB, you may be treated for TB before and during treatment with STELARA.

You should not start taking STELARA if you have any kind of infection unless your doctor says it is okay.

Before starting STELARA, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

After starting STELARA, call your doctor right away if you have any symptoms of an infection (see above).

STELARA can make you more likely to get infections or make an infection that you have worse. People who have a genetic problem where the body does not make any of the proteins interleukin 12 (IL-12) and interleukin 23 (IL-23) are at a higher risk for certain serious infections that can spread throughout the body and cause death. People who take STELARA may also be more likely to get these infections.

Cancers

STELARA may decrease the activity of your immune system and increase your risk for certain types of cancer. Tell your doctor if you have ever had any type of cancer. Some people who had risk factors for skin cancer developed certain types of skin cancers while receiving STELARA. Tell your doctor if you have any new skin growths.

Reversible posterior leukoencephalopathy syndrome (RPLS)

RPLS is a rare condition that affects the brain and can cause death. The cause of RPLS is not known. If RPLS is found early and treated, most people recover. Tell your doctor right away if you have any new or worsening medical problems including: headache, seizures, confusion, and vision problems.

Serious Allergic Reactions

Serious allergic reactions can occur. Stop using STELARA and get medical help right away if you have any symptoms such as: feeling faint, swelling of your face, eyelids, tongue, or throat, chest tightness, or skin rash.

Before receiving STELARA, tell your doctor if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or RPLS.

ever had an allergic reaction to STELARA or any of its ingredients. Ask your doctor if you are not sure.

are allergic to latex. The needle cover on the prefilled syringe contains latex.

have recently received or are scheduled to receive an immunization (vaccine). People who take STELARA should not receive live vaccines. Tell your doctor if anyone in your house needs a vaccine. The viruses used in some types of vaccines can spread to people with a weakened immune system, and can cause serious problems. You should not receive the BCG vaccine during the one year before taking STELARA or one year after you stop taking STELARA.

have any new or changing lesions within psoriasis areas or on normal skin.

are receiving or have received allergy shots, especially for serious allergic reactions.

receive or have received phototherapy for your psoriasis.

have any other medical conditions.

are pregnant or plan to become pregnant. It is not known if STELARA will harm your unborn baby. You and your doctor should decide if you will take STELARA.

are breast-feeding or plan to breast-feed. It is thought that STELARA passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take STELARA.

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of them to show your doctor and pharmacist when you get a new medicine.

When prescribed STELARA:

Use STELARA exactly as prescribed by your doctor.

If your doctor decides that you or a caregiver may give your injections of STELARA at home, you should receive training on the right way to prepare and inject STELARA. Do not try to inject STELARA yourself until you or your caregiver has been shown how to inject STELARA by your doctor or nurse.

Common side effects of STELARA include: upper respiratory infections, headache, and tiredness in psoriasis patients; joint pain and nausea in psoriatic arthritis patients; and upper respiratory infections, redness at the injection site, vaginal yeast infections, itching, urinary tract infections, and vomiting in Crohns disease patients. These are not all of the possible side effects with STELARA. Tell your doctor about any side effect that you experience. Ask your doctor or pharmacist for more information.

Please read the full Prescribing Information and Medication Guide for STELARA and discuss any questions you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

061408-161010

References

1. About the National Psoriasis Foundation. (n.d.) https://www.psoriasis.org/about-us. Accessed July 24, 2016.

2. National Psoriasis Foundation. About Psoriatic Arthritis. https://www.psoriasis.org/psoriatic-arthritis. Accessed November 3, 2016.

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My Life with Plaque Psoriasis and How I'm taking Control - The Killeen Daily Herald

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LeAnn Rimes: Psoriasis is ‘one of my biggest insecurities’ – Today.com

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LeAnn Rimes is a country music superstar who's been making hit records since she was only 13 years old. The powerhouse vocalist reflects on growing up in the spotlight and how she's been able to embrace her insecurities and own them with confidence!

One of my biggest insecurities is my skin. I've had psoriasis since I was 2 and was 80 percent covered by the time I was 6, so I was constantly in a state of covering up everything as a kid and feeling really uncomfortable.

RELATED: LeAnn Rimes shares adorable throwback photo from her first cassette tape

I didn't realize how much it had impacted my self-confidence and just really kind of feeling like a woman.

LeAnn Rimes isn't afraid to bare her skin after managing her psoriasis.

So there's been a ton of bikini photos of me in the past several years; it's because I would go naked if I could because I'm clear and it's all good!

I think music really was what gave me confidence.

RELATED: Ashley Graham: What I tell myself in the mirror to feel confident

I think I was very disconnected from my body so that was the one way I could really connect. So I think music has been a very, very healing thing for me.

"Music ... was a place for me to be able to escape in a way but also kind of come out of my shell."

I never thought I could get to the place where I could really be grateful for every single thing that's happened in my life ... but I am now and it feels really good.

RELATED: 'Forever Country' brings singers from past and present together for epic video

As I get older, I've learned how to accept the things that bother me about myself and really start to love those things. They're what make me, me.

My advice to others is to own it. Own who you are, because it feels really good when you do.

As told to TODAY's Jordan Muto.

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Local effects of adipose tissue in psoriasis and psoriatic arthritis – Dove Medical Press

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Back to Browse Journals Psoriasis: Targets and Therapy Volume 7

Ilja L Kruglikov,1 Uwe Wollina2

1Scientific Department, Wellcomet GmbH, Karlsruhe, 2Department of Dermatology and Allergology, Hospital Dresden-Friedrichstadt Academic Teaching Hospital of the Technical University of Dresden, Dresden, Germany

Abstract: The structure and physiological state of the local white adipose tissue (WAT) located underneath the lesional psoriatic skin and inside of the joints affected by psoriatic arthritis play an important role in the pathophysiology of these diseases. WAT pads associated with inflammatory sites in psoriasis and psoriatic arthritis are, correspondingly, dermal WAT and articular adipose tissue; these pads demonstrate inflammatory phenotypes in both diseases. Such local WAT inflammation could be the primary effect in the pathophysiology of psoriasis leading to the modification of the local expression of adipokines, a change in the structure of the basement membrane and the release of keratinocytes with consequent epidermal hyperproliferation during psoriasis. Similar articular adipose tissue inflammation can lead to the induction of structural modifications and synovial inflammation in the joints of patients with psoriatic arthritis.

Keywords: psoriasis, psoriatic arthritis, pathophysiology, adipose tissue, dermal adipocytes, articular adipose tissue

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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My Life with Plaque Psoriasis and How I’m taking Control – Bloomer … – Bloomer Advance (subscription)

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Plaque psoriasis is a chronic autoimmune skin disease that speeds up the growth cycle of skin cells, causing patches of thick red skin and silvery scales affecting approximately 6 million Americans.1

After talking with her doctor about her symptoms, she prescribed a biologic treatment called STELARA (ustekinumab).

Visit http://www.STELARAINFO.com to learn more about STELARA

WHAT IS STELARA?

STELARA is a prescription medicine approved to treat adults 18 years and older with active psoriatic arthritis, either alone or with methotrexate.

IMPORTANT SAFETY INFORMATION

STELARA (ustekinumab) is a prescription medicine that affects your immune system. STELARA can increase your chance of having serious side effects including:

Serious Infections

Your doctor should check you for TB before starting STELARA and watch you closely for signs and symptoms of TB during treatment with STELARA.

If your doctor feels that you are at risk for TB, you may be treated for TB before and during treatment with STELARA.

You should not start taking STELARA if you have any kind of infection unless your doctor says it is okay.

Before starting STELARA, tell your doctor if you:

think you have an infection or have symptoms of an infection such as:

After starting STELARA, call your doctor right away if you have any symptoms of an infection (see above).

Cancers

Reversible posterior leukoencephalopathy syndrome (RPLS)

Serious Allergic Reactions

Before receiving STELARA, tell your doctor if you:

have any of the conditions or symptoms listed above for serious infections, cancers, or RPLS.

ever had an allergic reaction to STELARA or any of its ingredients. Ask your doctor if you are not sure.

are allergic to latex. The needle cover on the prefilled syringe contains latex.

have any new or changing lesions within psoriasis areas or on normal skin.

are receiving or have received allergy shots, especially for serious allergic reactions.

receive or have received phototherapy for your psoriasis.

have any other medical conditions.

are pregnant or plan to become pregnant. It is not known if STELARA will harm your unborn baby. You and your doctor should decide if you will take STELARA.

are breast-feeding or plan to breast-feed. It is thought that STELARA passes into your breast milk. Talk to your doctor about the best way to feed your baby if you take STELARA.

When prescribed STELARA:

Use STELARA exactly as prescribed by your doctor.

Please read the full Prescribing Information and Medication Guide for STELARA and discuss any questions you have with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA.

Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.

061408-161010

References

1. About the National Psoriasis Foundation. (n.d.) https://www.psoriasis.org/about-us. Accessed July 24, 2016.

2. National Psoriasis Foundation. About Psoriatic Arthritis. https://www.psoriasis.org/psoriatic-arthritis. Accessed November 3, 2016.

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Daily Archives: February 7, 2017

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