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Daily Archives: January 28, 2017
World War III – Wikipedia
Posted: January 28, 2017 at 5:02 pm
World War III (WWIII or WW3) and Third World War are names given to a hypothetical third worldwide military conflict subsequent to World War I, and World War II. The term has been in use since the end of World War II. Some have applied it loosely to refer to limited or smaller conflicts such as the Cold War or the War on Terror, while others have operated under the assumption that such a conflict would surpass both prior World Wars in both the level of its widespread scope and of its overall destructive impact.[1]
Because of the development and use of nuclear weapons near the end of World War II and their subsequent acquisition and deployment by many countries, the potential risk of a nuclear devastation of Earth's civilization and life is a common theme in speculations of a Third World War. Another major concern is that biological warfare could cause a very large number of casualties, either intentionally or inadvertently by an accidental release of a biological agent, the unexpected mutation of an agent, or its adaptation to other species after use. High-scale apocalyptic events like these, caused by advanced technology used for destruction, could potentially make Earth's surface uninhabitable, what prompts many to believe that after the war, humans would live either in underground facilities or in colonies in space (such as on the Moon or Mars or in a space vehicle).
Prior to the advent of the Second World War, the First World War (19141918) was believed to have been the "war to end all wars," as it was believed that never again could there possibly be a global conflict of such magnitude. During this inter-war period, WW I was typically referred to simply as "The Great War" and was never referred to as World War I. World War II (19391945) disproved as incorrect, the idea that mankind might have somehow "outgrown" the need for such widespread wars.
With the advent of the Cold War in 1947 and with the spread of nuclear weapons technology to the Soviet Union, the possibility of a third global conflict became more plausible. During the Cold War years the possibility of a Third World War was anticipated and planned for by military and civil authorities in many countries. Scenarios ranged from conventional warfare to limited or total nuclear warfare. At the height of the Cold War, in a scenario referred to as MAD (Mutually Assured Destruction), it had been calculated that an all-out nuclear confrontation would most certainly destroy all or nearly all human life on the planet. The spectre of the potential of the absolute destruction of the human race may have contributed to the ability of both American and Soviet leaders to avoid such a scenario.
The Cold War ended in 1991 when the Soviet Union collapsed, leaving the United States as the sole global superpower. With the end of the Cold War, it was believed that the likelihood of a fully unrestricted nuclear confrontation between two superpowers was significantly diminished.
Military planners have been war gaming various scenarios, preparing for the worst, since the early days of the Cold War. Some of those plans are now out of date and have been partially or fully declassified.
British Prime Minister Winston Churchill was concerned that, with the enormous size of Soviet forces deployed in Europe at the end of WWII and the unreliability of the Soviet leader Joseph Stalin, there was a serious threat to Western Europe. In AprilMay 1945, British Armed Forces developed Operation Unthinkable, thought to be the first scenario of the Third World War.[2] Its primary goal was "to impose upon Russia the will of the United States and the British Empire".[3] The plan was rejected by the British Chiefs of Staff Committee as militarily unfeasible.
"Operation Dropshot" was the 1950s United States contingency plan for a possible nuclear and conventional war with the Soviet Union in the Western European and Asian theaters.
At the time the US nuclear arsenal was limited in size, based mostly in the United States, and depended on bombers for delivery. Dropshot included mission profiles that would have used 300 nuclear bombs and 29,000 high-explosive bombs on 200 targets in 100 cities and towns to wipe out 85% of the Soviet Union's industrial potential at a single stroke. Between 75 and 100 of the 300 nuclear weapons were targeted to destroy Soviet combat aircraft on the ground.
The scenario was devised prior to the development of intercontinental ballistic missiles. It was also devised before Robert McNamara and President Kennedy changed the US Nuclear War plan from the 'city killing' countervalue strike plan to "counterforce" (targeted more at military forces). Nuclear weapons at this time were not accurate enough to hit a naval base without destroying the city adjacent to it, so the aim in using them was to destroy the enemy industrial capacity in an effort to cripple their war economy.
In January 1950, the North Atlantic Council approved NATO's military strategy of containment.[4] NATO military planning took on a renewed urgency following the outbreak of the Korean War in the early 1950s, prompting NATO to establish a "force under a centralised command, adequate to deter aggression and to ensure the defence of Western Europe". Allied Command Europe was established under General of the Army Dwight D. Eisenhower, US Army, on 2 April 1951.[5][6] The Western Union Defence Organization had previously carried out Exercise Verity, a 1949 multilateral exercise involving naval air strikes and submarine attacks.
Exercise Mainbrace brought together 200 ships and over 50,000 personnel to practice the defence of Denmark and Norway from Russian attack in 1952. It was the first major NATO exercise. The exercise was jointly commanded by Supreme Allied Commander Atlantic Admiral Lynde D. McCormick, USN, and Supreme Allied Commander Europe General Matthew B. Ridgeway, US Army, during the Fall of 1952.
The US, UK, Canada, France, Denmark, Norway, Portugal, Netherlands, and Belgium all participated.
Exercises Grand Slam and Longstep were naval exercises held in the Mediterranean Sea during 1952 to practice dislodging an enemy occupying force and amphibious assault. It involved over 170 warships and 700 aircraft under the overall command of Admiral Carney. The overall exercise commander, Admiral Carney summarized the accomplishments of Exercise Grand Slam by stating: "We have demonstrated that the senior commanders of all four powers can successfully take charge of a mixed task force and handle it effectively as a working unit."[citation needed]
The USSR called the exercises "war-like acts" by NATO, with particular reference to the participation of Norway and Denmark, and prepared for its own military maneuvers in the Soviet Zone.[7][8]
This was a major NATO naval exercise held in 1957, simulating a response to an all-out Soviet attack on NATO. The exercise involved over 200 warships, 650 aircraft, and 75,000 personnel from the United States Navy, the United Kingdom's Royal Navy, the Royal Canadian Navy, the French Navy, the Royal Netherlands Navy, and the Royal Norwegian Navy. As the largest peacetime naval operation up to that time, Operation Strikeback was characterized by military analyst Hanson W. Baldwin of The New York Times as "constituting the strongest striking fleet assembled since World War II".[9]
Exercise Reforger (from return of forces to Germany) was an annual exercise conducted, during the Cold War, by NATO. The exercise was intended to ensure that NATO had the ability to quickly deploy forces to West Germany in the event of a conflict with the Warsaw Pact. The Warsaw Pact outnumbered NATO throughout the Cold War in conventional forces, especially armor. Therefore, in the event of a Soviet invasion, in order not to resort to tactical nuclear strikes, NATO forces holding the line against a Warsaw Pact armored spearhead would have to be quickly resupplied and replaced. Most of this support would have come across the Atlantic from the US and Canada.
Reforger was not merely a show of forcein the event of a conflict, it would be the actual plan to strengthen the NATO presence in Europe. In that instance, it would have been referred to as Operation Reforger. Important components in Reforger included the Military Airlift Command, the Military Sealift Command, and the Civil Reserve Air Fleet.
Seven Days to the River Rhine was a top secret military simulation exercise developed in 1979 by the Warsaw Pact. It started with the assumption that NATO would launch a nuclear attack on the Vistula river valley in a first-strike scenario, which would result in as many as two million Polish civilian casualties.[10] In response, a Soviet counter-strike would be carried out against West Germany, Belgium, the Netherlands and Denmark, with Warsaw Pact forces invading West Germany and aiming to stop at the River Rhine by the seventh day. Other USSR plans stopped only upon reaching the French border on day nine. Individual Warsaw Pact states were only assigned their own subpart of the strategic picture; in this case, the Polish forces were only expected to go as far as Germany. The Seven Days to the Rhine plan envisioned that Poland and Germany would be largely destroyed by nuclear exchanges, and that large numbers of troops would die of radiation sickness. It was estimated that NATO would fire nuclear weapons behind the advancing Soviet lines to cut off their supply lines and thus blunt their advance. While this plan assumed that NATO would use nuclear weapons to push back any Warsaw Pact invasion, it did not include nuclear strikes on France or the United Kingdom. Newspapers speculated when this plan was declassified, that France and the UK were not to be hit in an effort to get them to withhold use of their own nuclear weapons.
Exercise Able Archer was an annual exercise by the United States military in Europe that practiced command and control procedures, with emphasis on transition from solely conventional operations to chemical, nuclear, and conventional operations during a time of war.
"Able Archer 83" was a five-day North Atlantic Treaty Organization (NATO) command post exercise starting on 7 November 1983, that spanned Western Europe, centered on the Supreme Headquarters Allied Powers Europe (SHAPE) Headquarters in Casteau, north of the city of Mons. Able Archer exercises simulated a period of conflict escalation, culminating in a coordinated nuclear attack.[11]
The realistic nature of the 1983 exercise, coupled with deteriorating relations between the United States and the Soviet Union and the anticipated arrival of strategic Pershing II nuclear missiles in Europe, led some members of the Soviet Politburo and military to believe that Able Archer 83 was a ruse of war, obscuring preparations for a genuine nuclear first strike.[11][12][13][14] In response, the Soviets readied their nuclear forces and placed air units in East Germany and Poland on alert.[15][16] This "1983 war scare" is considered by many historians to be the closest the world has come to nuclear war since the Cuban Missile Crisis of 1962.[17] The threat of nuclear war ended with the conclusion of the exercise on 11 November.[18][19]
The Strategic Defense Initiative (SDI) was proposed by US President Ronald Reagan on 23 March 1983.[20] In the later part of his Presidency, numerous factors (which included watching the 1983 movie The Day After and hearing through a Soviet defector that Able Archer 83 almost triggered a Russian first strike) had turned Ronald Reagan against the concept of winnable nuclear war, and he began to see nuclear weapons as more of a "wild card" than a strategic deterrent. Although he later believed in disarmament treaties slowly blunting the danger of nuclear weaponry by reducing their number and alert status, he also believed a technological solution might allow incoming ICBMs to be shot down, thus making the US invulnerable to a first strike. However the USSR saw the SDI concept as a major threat, since unilateral deployment of the system would allow the US to launch a massive first strike on the Soviet Union without any fear of retaliation.
The SDI concept was to use ground-based and space-based systems to protect the United States from attack by strategic nuclear ballistic missiles. The initiative focused on strategic defense rather than the prior strategic offense doctrine of Mutual Assured Destruction (MAD). The Strategic Defense Initiative Organization (SDIO) was set up in 1984 within the United States Department of Defense to oversee the Strategic Defense Initiative.
NATO operational plans for a Third World War have involved NATO allies who do not have their own nuclear weapons, using nuclear weapons supplied by the United States as part of a general NATO war plan, under the direction of NATO's Supreme Allied Commander.
Of the three nuclear powers in NATO (France, the United Kingdom and the United States), only the United States has provided weapons for nuclear sharing. As of November 2009[update], Belgium, Germany, Italy, the Netherlands and Turkey are still hosting US nuclear weapons as part of NATO's nuclear sharing policy.[21][22]Canada hosted weapons until 1984,[23] and Greece until 2001.[21][24] The United Kingdom also received US tactical nuclear weapons such as nuclear artillery and Lance missiles until 1992, despite the UK being a nuclear weapons state in its own right; these were mainly deployed in Germany.
In peace time, the nuclear weapons stored in non-nuclear countries are guarded by US airmen though previously some artillery and missile systems were guarded by US Army soldiers; the codes required for detonating them are under American control. In case of war, the weapons are to be mounted on the participating countries' warplanes. The weapons are under custody and control of USAF Munitions Support Squadrons co-located on NATO main operating bases who work together with the host nation forces.[21]
As of 2005[update], 180 tactical B61 nuclear bombs of the 480 US nuclear weapons believed to be deployed in Europe fall under the nuclear sharing arrangement.[25] The weapons are stored within a vault in hardened aircraft shelters, using the USAF WS3 Weapon Storage and Security System. The delivery warplanes used are F-16s and Panavia Tornados.[26]
Norman Podhoretz has suggested that the Cold War can be identified as World War III[39] because it was fought, although by proxy, on a global scale, involving the United States, NATO, the Soviet Union and Warsaw Pact countries.[citation needed] Similarly, Eliot Cohen, the director of strategic studies at the Paul H. Nitze School of Advanced International Studies at Johns Hopkins University, declared, in The Wall Street Journal, that he considers World War III to be history, writing: "The Cold War was World War III, which reminds us that not all global conflicts entail the movement of multi-million-man armies, or conventional front lines on a map."[40] On the 24 May 2011 edition of CNBC's Kudlow and Company, host Lawrence Kudlow, discussing a book by former deputy Under-Secretary of Defense Jed Babbin, accepted the view of the Cold War as World War III, adding, "World War IV is the terror war, and war with China would be World War V."[41] However, not everyone accepts this definition of the Cold War as World War III. In his book Secret Weapons of the Cold War, Bill Yenne contends that "[the Cold War] was what occurred between the two 'Superpowers' the United States and the Soviet Union in lieu of World War III."[42]
On 1 February 2015, Iraq's Prime Minister declared that the War on ISIL was effectively "World War III", due to ISIS' declaration of a Worldwide Caliphate, its aims to conquer the world, and its success in spreading the conflict to multiple countries outside of the Levant region.[43] In response to the November 2015 Paris attacks, King of Jordan Abdullah II said "We are facing a Third World War [within Islam].[44]Pope Francis of Vatican City is quoted as saying, "perhaps one can speak of a third (world) war, one fought piecemeal."[45]
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THC – Psychedelics
Posted: at 5:02 pm
THC is the crystalline substance that forms on the outside of the marijuana plant. It is the substance in marijuana responsible for its euphoric effects.
THC is known scientifically as tetrahydrocannabinol and it is the active chemical found in marijuana. THC is the most widely abused drug in the United States and continues to be controversial in both cases of personal consumption and in cases of being appropriate for certain medical uses.
THC comes from the marijuana plant also known as cannabis sativa. Tetrahydrocannabinol, or THC is the active ingredient in the marijuana plant and the primary ingredient responsible for producing the euphoric effects of the drug.
THC resembles a crystaline that forms on the outside of the buds of the marijuana plant. Some people believe that THC can be used for medical purposes while others believe that there are no known medical uses that are considered safe. Regardless, THC is found in all variations of marijuana though medical marijuana often contains lower or higher levels of THC depending on the preference of the user and why it is being used.
The effects of THC vary from one user to the next but generally include sedation and relaxation. As the THC enters the bloodstream the user will feel the effects of the drug which can last up to 3 hours following the initial onset of effects. If marijuana is not smoked but is rather ingested, the user will feel the effects of THC about thirty minutes after it is consumed and the effects will generally last about 4 hours.
THC causes the dopamine release that takes place in the body to occur more quickly which can lead to heightened euphoria. Many users experience heightened awareness and sensitivity to sound, light and color. Perception of time is normally reduced and the user will feel as if time is taking longer to pass.
Smoking THC will lead to increased thirst and feelings of dehydration. The user will have dry mouth and may experience intense hunger while under the influence of THC. Many people experience heightened anxiety and even panic when under the influence of THC.
Using THC or marijuana can lead to an array of complications for the user. If the drug is regularly smoked, complications include damage to the lungs, susceptibility to infection, lung cancer and other serious side effects. Ingesting THC will not lead to respiratory problems but can still have implications in terms of increasing fear and anxiety, increasing risk of depression and altering appetite.
Sustained marijuana use, even in low doses, will cause the user to feel a lack of coordination and a lack of concentration. Over time, people who abuse marijuana are more likely to experience memory loss, coordination loss and additional problems related to impaired short term memory. Studies have proven that marijuana causes difficulty and impairment for students that can last for up to a full month after the drug is used, in some cases the aftermath will continue for many months after the last use of the drug.
Increased risk of psychosis and schizophrenia has been reported with chronic marijuana use. THC use can cause adverse problems in work, home and school. Social effects include isolation and may lead to depression. Heavy marijuana users suffer great damage to their social status and may require long term counseling in order to fully turn their lives around post marijuana addiction.
Is THC addictive? Yes!
Marijuana is an addictive substance that will lead to erratic drug-seeking behavior and a series of withdrawal symptoms when the user tries to quit. Although the symptoms of marijuana withdrawal are not dangerous or potentially deadly for the user, there are a number of risks associated with marijuana addiction.
Becoming addicted to THC will likely cause problems in the users relationship and may lead to financial implications that make quitting even more difficult. People who regularly smoke pot are likely to suffer an array of consequences including health problems, emotional problems, family and relationship problems, legal trouble, social isolation and individual isolation as a result of their addiction to THC.
The best way to prevent addiction to THC is to not smoke pot. With all of the controversy that is taking place about marijuana and the intended medical uses of the drug, its easy to fall into a mindset in which it would seem like smoking pot is ok to some degree but this can lead to physical and psychological dependence which will result in an array of consequences for the user.
Treatment is often required when a user becomes addicted to THC. Counseling and therapy are the most effective means of treatment but medication may be necessary if dopamine levels have been depleted to a point in which they cannot be restoredthis is yet another reason to avoid smoking pot.
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Eczema Information from Drugs.com
Posted: at 4:43 pm
Atopic dermatitis, commonly referred to as eczema, is a chronic skin disorder categorized by scaly and itching rashes. People with eczema often have a family history of allergic conditions like asthma, hayfever or eczema.
Eczema is most common in infants (where it is known as infantile eczema) and at least half of those cases clear by age 3. In adults, it is generally a chronic or recurring condition.
A hypersensitivity reaction (similar to an allergy) occurs in the skin, causing chronic inflammation. The inflammation causes the skin to become itchy and scaly. Chronic irritation and scratching can cause the skin to thicken and have a texture like leather. Exposure to environmental irritants can worsen symptoms, as can dryness of the skin, exposure to water, temperature changes, and stress.
Studies have shown that children who are breast-fed are less likely to get eczema. This is also true when the nursing mother has avoided cow's milk in her diet. Other dietary restrictions may include eggs, fish, peanuts, and soy.
Eczema tends to run in families. Control of stress, nervousness, anxiety, and depression can be beneficial in treating/avoiding eczema in some cases.
Diagnosis is primarily based on the appearance of the skin and on personal and family history. The health care provider should examine the lesions to rule out other possible causes. A skin lesion biopsy may be performed, but is not always required to make the diagnosis.
Call and make an appointment with your health care provider if your eczema does not respond to moisturizers or avoiding known allergens, if your symptoms worsen, if treatment is ineffective, or if signs of infection (such as fever, redness, pain) occur.
Consult your health care provider for a diagnosis of eczema because it can be difficult to differentiate from other skin disorders. Treatment should be guided by the health care provider.
Treatment may vary depending on the appearance (stage) of the lesions -- acute "weeping" lesions, dry scaly lesions, or chronic dry, thickened lesions are each treated differently.
Anything that aggravates the symptoms should be avoided whenever possible, including any food allergens and irritants such as wool and lanolin.
Dry skin often makes the condition worse. When washing or bathing, keep water contact as brief as possible and use less soap than usual. After bathing, it is important to trap the moisture in the skin by applying lubricating cream on the skin while it is damp. Temperature changes and stress may cause sweating and aggravate the condition.
Treatment of weeping lesions may include soothing moisturizers, mild soaps, or wet dressings.
Mild anti-itch lotions or topical corticosteroids (low potency) may soothe less severe or healing areas or dry scaly lesions.
Chronic thickened areas may be treated with ointments or creams that contain tar compounds, corticosteroids (medium to very high potency), and ingredients that lubricate or soften the skin. Systemic corticosteroids may be prescribed to reduce inflammation in some severe cases.
The latest treatment for eczema is a class of skin medications called topical immunomodulators (TIMs). These medications are steroid-free. They include tacrolimus (Protopic) and pimecrolimus (Elidel). Studies have shown a success rate as high as 80% among patients using these new medications.
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Eczema Information from Drugs.com
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Neo-eugenics | definition of Neo-eugenics by Medical …
Posted: at 1:01 am
eugenics [u-jeniks]
the study and control of procreation as a means of improving hereditary characteristics of future generations. The concept has sometimes been used in a pseudoscientific way as an excuse for unethical, racist, or even genocidal practices such as involuntary sterilization or certain other practices in Nazi Germany and elsewhere.
macro eugenics eugenics policies that affect whole populations or groups. This has sometimes led to racism and genocide, such as the Nazi policies of sterilization and extermination of ethnic groups.
micro eugenics eugenics policies affecting only families or kinship groups; such policies are directed mainly at women and thus raise special ethical issues.
negative eugenics that concerned with prevention of reproduction by individuals considered to have inferior or undesirable traits.
positive eugenics that concerned with promotion of optimal mating and reproduction by individuals considered to have desirable or superior traits.
1. Practices and policies, as of mate selection or of sterilization, which tend to better the innate qualities of progeny and human stock.
2. Practices and genetic counseling directed to anticipating genetic disability and disease.
[G. eugeneia, nobility of birth, fr. eu, well, + genesis, production]
The study or practice of attempting to improve the human gene pool by encouraging the reproduction of people considered to have desirable traits and discouraging or preventing the reproduction of people considered to have undesirable traits.
eugenic adj.
eugenically adv.
Etymology: Gk, eu + genein, to produce
the study of methods for controlling the characteristics of populations through selective breeding.
1. Practices and policies, as in mate selection or sterilization, which tend to better the innate qualities of progeny and human stock.
2. Practices and genetic counseling directed to anticipating genetic disability and disease.
[G. eugeneia, nobility of birth, fr. eu, well, + genesis, production]
A social movement in which the population of a society, country, or the world is to be improved by controlling the passing on of hereditary information through mating.
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Cyberpunk Books – goodreads.com
Posted: at 12:58 am
Cyberpunk is a subgenre of science fiction in a future setting that tends to focus on society as "high tech low life" featuring advanced technological and scientific achievements, such as information technology and cybernetics, juxtaposed with a degree of breakdown or radical change in the social order.
Cyberpunk plots often center on conflict among artificial intelligences, hackers, and among megacorporations, and tend to be set in a near-future Earth, rather than in the far-future settings or galactic vistas found in novels such as Isaac Asimov's Foundation or Frank Herbert's Dune.The setting
Cyberpunk plots often center on conflict among artificial intelligences, hackers, and among megacorporations, and tend to be set in a near-future Earth, rather than in the far-future settings or galactic vistas found in novels such as Isaac Asimov's Foundation or Frank Herbert's Dune.The settings are usually post-industrial dystopias but tend to feature extraordinary cultural ferment and the use of technology in ways never anticipated by its original inventors ("the street finds its own uses for things"). Much of the genre's atmosphere echoes film noir, and written works in the genre often use techniques from detective fiction.
Classic cyberpunk characters were marginalized, alienated loners who lived on the edge of society in generally dystopic futures where daily life was impacted by rapid technological change, an ubiquitous datasphere of computerized information, and invasive modification of the human body. Lawrence Person
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Transcranial magnetic stimulation – Wikipedia
Posted: at 12:58 am
Transcranial magnetic stimulation (TMS) is a magnetic method used to stimulate small regions of the brain. During a TMS procedure, a magnetic field generator, or "coil", is placed near the head of the person receiving the treatment.[1]:3 The coil produces small electric currents in the region of the brain just under the coil via electromagnetic induction. The coil is connected to a pulse generator, or stimulator, that delivers electric current to the coil.[2]
TMS is used diagnostically to measure the connection between the brain and a muscle to evaluate damage from stroke, multiple sclerosis, amyotrophic lateral sclerosis, movement disorders, motor neuron disease and injuries and other disorders affecting the facial and other cranial nerves and the spinal cord.[3]
Evidence suggests it is useful for neuropathic pain[4] and treatment-resistant major depressive disorder.[4][5] A 2015 Cochrane review found not enough evidence to make any conclusions in schizophrenia.[6] For negative symptoms another review found possible efficacy.[4] As of 2014, all other investigated uses of repetitive TMS have only possible or no clinical efficacy.[4]
Matching the discomfort of TMS to distinguish true effects from placebo is an important and challenging issue that influences the results of clinical trials.[4][7][8][9] The greatest risks of TMS are the rare occurrence of syncope (fainting) and even less commonly, induced seizures.[7] Other adverse effects of TMS include discomfort or pain, transient induction of hypomania, transient cognitive changes, transient hearing loss, transient impairment of working memory, and induced currents in electrical circuits in implanted devices.[7]
The use of TMS can be divided into diagnostic and therapeutic uses.
TMS can be used clinically to measure activity and function of specific brain circuits in humans.[3] The most robust and widely accepted use is in measuring the connection between the primary motor cortex and a muscle to evaluate damage from stroke, multiple sclerosis, amyotrophic lateral sclerosis, movement disorders, motor neuron disease and injuries and other disorders affecting the facial and other cranial nerves and the spinal cord.[3][10][11][12] TMS has been suggested as a means of assessing short-interval intracortical inhibition (SICI) which measures the internal pathways of the motor cortex but this use has not yet been validated.[13]
For neuropathic pain, for which there is little effective treatment, high-frequency (HF) repetitive TMS (rTMS) appears effective.[4] For treatment-resistant major depressive disorder, HF-rTMS of the left dorsolateral prefrontal cortex (DLPFC) appears effective and low-frequency (LF) rTMS of the right DLPFC has probable efficacy.[4][5] The Royal Australia and New Zealand College of Psychiatrists has endorsed rTMS for treatment resistant MDD.[14] As of October 2008, the US Food and Drug Administration authorized the use of rTMS as an effective treatment for clinical depression.[15]
Although TMS is generally regarded as safe, risks increase for therapeutic rTMS compared to single or paired TMS for diagnostic purposes.[16] In the field of therapeutic TMS, risks increase with higher frequencies.[7]
The greatest immediate risk is the rare occurrence of syncope (fainting) and even less commonly, induced seizures.[7][17]
Other adverse short-term effects of TMS include discomfort or pain, transient induction of hypomania, transient cognitive changes, transient hearing loss, transient impairment of working memory, and induced currents in electrical circuits in implanted devices.[7]
During a transcranial magnetic stimulation (TMS) procedure, a magnetic field generator, or "coil" is placed near the head of the person receiving the treatment.[1]:3 The coil produces small electric currents in the region of the brain just under the coil via electromagnetic induction. The coil is positioned by finding anatomical landmarks on the skull including, but not limited to, the inion or the nasion.[18] The coil is connected to a pulse generator, or stimulator, that delivers electric current to the coil.[2]
The ANT Neuro neuronavigation solution visor2 was approved as a CE class IIa medical device in April 2012.
Nexstim obtained 510(k) FDA clearance of Navigated Brain Stimulation for the assessment of the primary motor cortex for pre-procedural planning in December 2009.[19]
Nexstim obtained FDA 510K clearance for NexSpeech navigated brain stimulation device for neurosurgical planning in June 2011.[20]
A number of deep TMS have received FDA 510k clearance to market for use in adults with treatment resistant major depressive disorders.[21][22][23][24]
The use of single-pulse TMS was approved by the FDA for treatment of migraines in December 2013.[25] It is approved as a Class II medical device under the "de novo pathway".[26][27]
In 2013, several commercial health insurance plans in the United States, including Anthem, Health Net, and Blue Cross Blue Shield of Nebraska and of Rhode Island, covered TMS for the treatment of depression for the first time.[28] In contrast, UnitedHealthcare issued a medical policy for TMS in 2013 that stated there is insufficient evidence that the procedure is beneficial for health outcomes in patients with depression. UnitedHealthcare noted that methodological concerns raised about the scientific evidence studying TMS for depression include small sample size, lack of a validated sham comparison in randomized controlled studies, and variable uses of outcome measures.[29] Other commercial insurance plans whose 2013 medical coverage policies stated that the role of TMS in the treatment of depression and other disorders had not been clearly established or remained investigational included Aetna, Cigna and Regence.[30]
Policies for Medicare coverage vary among local jurisdictions within the Medicare system,[31] and Medicare coverage for TMS has varied among jurisdictions and with time. For example:
The United Kingdom's National Institute for Health and Care Excellence (NICE) issues guidance to the National Health Service (NHS) in England, Wales, Scotland and Northern Ireland. NICE guidance does not cover whether or not the NHS should fund a procedure. Local NHS bodies (primary care trusts and hospital trusts) make decisions about funding after considering the clinical effectiveness of the procedure and whether the procedure represents value for money for the NHS.[36]
NICE evaluated TMS for severe depression (IPG 242) in 2007, and subsequently considered TMS for reassessment in January 2011 but did not change its evaluation.[37] The Institute found that TMS is safe, but there is insufficient evidence for its efficacy.[37]
In January 2014, NICE reported the results of an evaluation of TMS for treating and preventing migraine (IPG 477). NICE found that short-term TMS is safe but there is insufficient evidence to evaluate safety for long-term and frequent uses. It found that evidence on the efficacy of TMS for the treatment of migraine is limited in quantity, that evidence for the prevention of migraine is limited in both quality and quantity.[38]
TMS uses electromagnetic induction to generate an electric current across the scalp and skull without physical contact. A plastic-enclosed coil of wire is held next to the skull and when activated, produces a magnetic field oriented orthogonally to the plane of the coil. The magnetic field passes unimpeded through the skin and skull, inducing an oppositely directed current in the brain that activates nearby nerve cells in much the same way as currents applied directly to the cortical surface.[39]
The path of this current is difficult to model because the brain is irregularly shaped and electricity and magnetism are not conducted uniformly throughout its tissues. The magnetic field is about the same strength as an MRI, and the pulse generally reaches no more than 5 centimeters into the brain unless using the deep transcranial magnetic stimulation variant of TMS.[40] Deep TMS can reach up to 6cm into the brain to stimulate deeper layers of the motor cortex, such as that which controls leg motion.[41]
From the BiotSavart law
it has been shown that a current through a wire generates a magnetic field around that wire. Transcranial magnetic stimulation is achieved by quickly discharging current from a large capacitor into a coil to produce pulsed magnetic fields between 2 and 3 T.[42] By directing the magnetic field pulse at a targeted area of the brain, one can either depolarize or hyperpolarize neurons in the brain. The magnetic flux density pulse generated by the current pulse through the coil causes an electric field as explained by the Maxwell-Faraday equation,
This electric field causes a change in the transmembrane current of the neuron, which leads to the depolarization or hyperpolarization of the neuron and the firing of an action potential.[42]
The exact details of how TMS functions are still being explored. The effects of TMS can be divided into two types depending on the mode of stimulation:
MRI images, recorded during TMS of the motor cortex of the brain, have been found to match very closely with PET produced by voluntary movements of the hand muscles innervated by TMS, to 522mm of accuracy.[45] The localisation of motor areas with TMS has also been seen to correlate closely to MEG[46] and also fMRI.[47]
The design of transcranial magnetic stimulation coils used in either treatment or diagnostic/experimental studies may differ in a variety of ways. These differences should be considered in the interpretation of any study result, and the type of coil used should be specified in the study methods for any published reports.
The most important considerations include:
With regard to coil composition, the core material may be either a magnetically inert substrate (i.e., the so-called 'air-core' coil design), or possess a solid, ferromagnetically active material (i.e., the so-called 'solid-core' design). Solid core coil design result in a more efficient transfer of electrical energy into a magnetic field, with a substantially reduced amount of energy dissipated as heat, and so can be operated under more aggressive duty cycles often mandated in therapeutic protocols, without treatment interruption due to heat accumulation, or the use of an accessory method of cooling the coil during operation. Varying the geometric shape of the coil itself may also result in variations in the focality, shape, and depth of cortical penetration of the magnetic field. Differences in the coil substance as well as the electronic operation of the power supply to the coil may also result in variations in the biophysical characteristics of the resulting magnetic pulse (e.g., width or duration of the magnetic field pulse). All of these features should be considered when comparing results obtained from different studies, with respect to both safety and efficacy.[48]
A number of different types of coils exist, each of which produce different magnetic field patterns. Some examples:
Design variations in the shape of the TMS coils allow much deeper penetration of the brain than the standard depth of 1.52.5cm. Circular crown coils, Hesed (or H-core) coils, double cone coils, and other experimental variations can induce excitation or inhibition of neurons deeper in the brain including activation of motor neurons for the cerebellum, legs and pelvic floor. Though able to penetrate deeper in the brain, they are less able to produce a focused, localized response and are relatively non-focal.[7]
Early attempts at stimulation of the brain using a magnetic field included those, in 1896, of Jacques-Arsne d'Arsonval in Paris and in 1910, of Silvanus P. Thompson in London.[50] The principle of inductive brain stimulation with eddy currents has been noted since the 20th century[citation needed]. The first successful TMS study was performed in 1985 by Anthony Barker and his colleagues at the Royal Hallamshire Hospital in Sheffield, England.[51] Its earliest application demonstrated conduction of nerve impulses from the motor cortex to the spinal cord, stimulating muscle contractions in the hand. As compared to the previous method of transcranial stimulation proposed by Merton and Morton in 1980[52] in which direct electric current was applied to the scalp, the use of electromagnets greatly reduced the discomfort of the procedure, and allowed mapping of the cerebral cortex and its connections.
TMS research in animal studies is limited due to early FDA approval of TMS treatment of drug-resistant depression. Because of this, there has been no specific coils for animal models. Hence, there are limited number of TMS coils that can be used for animal studies.[53] There are some attempts in the literature showing new coil designs for mice with an improved stimulation profile.[54]
Areas of research include:
It is difficult to establish a convincing form of "sham" TMS to test for placebo effects during controlled trials in conscious individuals, due to the neck pain, headache and twitching in the scalp or upper face associated with the intervention.[4][7] "Sham" TMS manipulations can affect cerebral glucose metabolism and MEPs, which may confound results.[67] This problem is exacerbated when using subjective measures of improvement.[7] Placebo responses in trials of rTMS in major depression are negatively associated with refractoriness to treatment, vary among studies and can influence results.[68]
A 2011 review found that only 13.5% of 96 randomized control studies of rTMS to the dorsolateral prefrontal cortex had reported blinding success and that, in those studies, people in real rTMS groups were significantly more likely to think that they had received real TMS, compared with those in sham rTMS groups.[69] Depending on the research question asked and the experimental design, matching the discomfort of rTMS to distinguish true effects from placebo can be an important and challenging issue.[4][7][8][9]
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Virtual Reality Gets Real – theatlantic.com
Posted: at 12:55 am
In 1965, Ivan Sutherland, a computer-graphics pioneer, addressed an international meeting of techies on the subject of virtual reality. The ultimate virtual-reality display, he told the audience, would be a room within which the computer can control the existence of matter. A chair displayed in such a room would be good enough to sit in. Handcuffs displayed in such a room would be confining, and a bullet displayed in such a room would be fatal. With appropriate programming, such a display could literally be the Wonderland into which Alice walked.
Virtual reality has advanced rapidly in the past couple of yearsthe much-anticipated Oculus Rift headset is expected to arrive in stores in early 2016, followed closely by several other devices. Yet the technology is still very new, and Sutherlands vision seems little closer to, well, actual reality. Right now, its like when you first had cellphones, Richard Marks, one of the lead engineers working on Project Morpheus, Sonys virtual-reality headset, told me. A lot of focus is still on the most-basic things.
I recently spoke with scientists, psychologists, engineers, and developers about the possibilities for this emerging field. Where might it eventually take usand will that be somewhere we want to go?
Being Virtually Anywhere
During a recent demonstration of Google Cardboarda DIY headset thats made of cardboard and uses a smartphone for the displayI found myself by turns atop a rocky peak, in a barn next to a snorting horse, and on a gondola making my way up a mountain. The gondola ride gave me vertigo.
We react like that, experts say, because our brains are easily fooled when what we see on a display tracks our head movements. We have a reptilian instinct that responds as if its real: Dont step off that cliff; this battle is scary, Jeremy Bailenson, the founding director of Stanfords Virtual Human Interaction Lab, told me. The brain hasnt evolved to tell you its not real.
Much of the excitement about virtual reality has come from the gaming community. Who wouldnt want to experience a game so completely? But gaming is just the start. At Sony, Marks has worked with NASA to conjure the experience of standing on Marsa view that could help scientists better understand the planet. David Laidlaw, the head of the Visualization Research Lab at Brown University, told me that his team has re-created a temple site in Petra, Jordan, enabling researchers to see previously unclear relationships between objects found there.
Google is testing Expeditions, a way of sending students to places like the Great Barrier Reef, where they can virtually scuba dive as part of a lesson on marine biology and ocean acidification. Similar approaches may enhance professional training. By donning a pair of goggles, a neurosurgeon could navigate brain structures before surgery; a chemist could step inside a drug to understand it on the cellular level; an architect could walk through a building shes designing.
Another possibility: Imagine that youre unable to attend a family gathering. With a pair of glasses, youre in the middle of the action. And everyone there wears glasses that make it appear as though youre present. The whole thing is recorded, so you can replay the experience whenever youd like. Ten years from now, such a scenario might be common.
And consider the potential for telecommuting. Henry Fuchs, a professor at the University of North Carolina at Chapel Hill and a leader in the field, envisions virtual offices. You could use the physical space of your housea real desk, a real computerbut interact with your colleagues as if they were in the same room as you.
Seeing Through Others Eyes
In his lab at Stanford, Bailenson studies how virtual reality changes behavior. Hes found that if your avatar is taller than you are in real life, you become more confident. If you have a particularly attractive avatar, you become friendlier. If youre young and you have an avatar that is a senior citizen, you save more money. These changes last even after you leave the virtual realm.
And avatars could soon become more convincing. Most commercial virtual-reality systems capture only the movement of your head and hands. In 2013, though, Apple acquired PrimeSense, an Israeli company developing technology to track the movements of your whole body with infrared sensors and special microchips. And a company called Faceshift is working to capture facial expressions, so that if you smile or roll your eyes, your avatar will too.
Virtual reality has already proved useful in treating phobias and PTSD. It can help people overcome a fear of heights, for example, through simulations of standing on a balcony or walking across a bridge. Bailenson and others think it could also be used to build empathy. What if you could step inside a documentary, rather than just watching it on a screenalmost literally walking in someone elses shoes? That was the goal of Clouds Over Sidra, a virtual-reality filmcreated through a partnership between the United Nations and Samsungthat followed a 12-year-old girl in a Syrian-refugee camp in Jordan.
And what if you could do something similar in real time? Combine this sort of immersive storytelling, as it evolves, with technologies like Periscope and Meerkatapps that let users stream live videoand you can in essence see the world through anyones eyes, Clay Bavor, the head of Googles virtual-reality initiatives, told me. A protester in Cairo or Athens or Baltimore, for example, could use a special camera to give people around the world a 360-degree view of what its like to be there.
Engaging All Your Senses
Google recently acquired Thrive Audio, a company that specializes in spatial audiosounds that your ear registers as emanating from a particular place. A virtual waterfall grows louder as you move toward it. Something catches your ear from behind. You turn, and see a deer approaching. The audio becomes three-dimensional, truly surrounding you.
Smell could become part of the virtual experience as well. A company called Feelreal has developed a mask that releases scents, such as the smell of fire or the ocean, to enhance what you see in a headset. (The project is hampered by the need to preload the scents youre likely to encounter, among other problems.) Closely related is the ability to taste what you see. Researchers in Singapore are developing electrodes that, when placed on your tongue, mimic basic tastes, such as sweet, salty, bitter, and sour.
What about touch? Could we one day find that when we dip our fingers in virtual water, it actually feels wet? David Laidlaw considers resolving this challenge, known as the haptics problem, to be the holy grail of virtual reality. But that doesnt mean its insurmountable. Im confident well do it within our lifetimes, Palmer Luckey, the founder of Oculus, told me. There are no fundamental physical laws that prevent us from building something thats almost perfect. Laidlaw is less optimistiche thinks that creating lifelike haptics will take 100 yearsbut he agrees that a virtual world may one day be a nearly perfect simulacrum of the real one.
Of course, there could be unintended consequences. Already people are developing vision problems and vitaminD deficienciesnot to mention obesity and diabetesbecause they spend too much time in front of screens. (See The Nature Cure.) What might a flawlessly rendered virtual world mean for our health?
A Neuromancer Future?
Jeremy Bailenson was inspired to work in virtual reality in part by Neuromancer, a 1984 novel that depicts a future in which people can jack in their brains directly to a virtual world. Perhaps, Bailenson speculates, thats where virtual reality is headed. He imagines that in 50 or 100 years we might develop a brain-machine interface that taps directly into the nervous system.
Perhaps then well find that rather than jacking in for a while and calling it quits, we can, like Alice, move wholly into a Wonderland where the laws of the prosaic world (gravity, aging) no longer apply. Virtual reality could then become akin to the Singularity, a concept described by Ray Kurzweil, a futurist and Google engineer, among others: a way for our minds to separate from our bodies and, uploaded into a digital realm, live on even as our physical selves grow old and die. Just like Wonderland, its a vision equal parts entrancing and frightening.
1930: The first mechanical flight simulator is patented.
194245: The U.S. military uses View-Masters for training during World War II. The device later becomes a popular childrens toy.
1962: Morton Heilig patents the Sensorama, an experience theater featuring 3D video, a vibrating chair, fans, and artificial smells.
1968: MIT develops the first virtual-reality headset, a device so heavy, it must be suspended from the ceiling. Its nickname: the Sword of Damocles.
1996: Virtual Boy, Nintendos 3D video-game console, is discontinued because it causes nausea.
2014: Facebook buys Oculus, a virtual-reality company, for $2 billion.
2115: Virtual reality incorporates haptic sensations, enabling users to touch what they see.
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Test Automation Services for Development of Regression …
Posted: at 12:54 am
Gallop is a leader in providing test automation services and has built a dedicated Automation Center of Excellence (ACoE) backed by a decade of experience in executing test automation engagements for global clients & a large pool of test automation experts. Gallop Test Automation Accelerator Kit (GTAAK) comprises of pre-built test automation scripts, utilities, process assets and frameworks, and has helped many companies in implementing successful test automation initiatives.
Gallops test automation strategy enables organizations to increase release velocity, reduce time to market and reduce overall testing effort resulting in significant return on investment (ROI). Gallop has developed a tool and technology agnostic, plug-and-play test automation framework with pre-built interfaces to CI servers, application lifecycle management tools and defect management tools that fully support the majority of test automation tools adopted by organizations.
Gallop invests over a $1mn annually to develop intellectual property and has committed partnerships with industry leading automation tool vendors to complement innovation. Gallop is also an active contributor in open source platforms for test automation and is a silver sponsor of Selenium. Gallop has also developed a host of pre-built automated test suites for industry leading 3rd party products like SAP, Oracle, PeopleSoft, Salesforce, SAP Hybris, MS Dynamics CRM, and Work Day.
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Automation | Technologies | Systems | Integrator …
Posted: at 12:53 am
Automation Technologies is an engineering and software development firm that offers the highest level of experience in industrial automation and process control. Our reputation for quality, reliability and affordability has been built on superior products and services provided for various industries including pharmaceutical, chemical, polymer, plastic, textile, and pulp and paper.
When you choose Automation Technologies, you benefit from the technical experience of senior engineers and specialists who average more than 15 years in their fields of automation and process control. With our broad network of corporate partners, Automation Technologies can meet virtually any automation and controls need, providing our customers with "one-stop-shopping" for technically superior solutions backed by outstanding service and support.
Wherever you are in the automation process, from planning to implementation, Automation Technologies has the experience, knowledge and flexibility to keep your company on the leading edge of automation and process control.
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Automation – Mazak Corporation
Posted: at 12:53 am
Automation can enhance your productivity through increased machine tool utilization. However, to reap the significant competitive advantages that coincide with automation, you must efficiently and effectively integrate it into your operations.
We are a single source provider for all your automation needs. And to ensure you have the right automation for your facility, we have developed 4 various levels of automation to fulfill your specific production needs.
Bar feeders offer immediate increases in productivity. However, while they are a basic form of automation, its important to select the right one to ensure you achieve increased material utilization as well as gain the highest levels of productivity, throughput and quality from your turning operations.
Gantry loaders provide fast, high-production loading and unloading. They bring more versatility, flexibility and productivity when managing chuck and shaft work by offering a variety of loading stations and robotic hands. Gantry loader systems are easy to install and operate, providing a quick, turnkey system that results in immediate increases in productivity.
Offering amazing production flexibility, our PALLETECH system brings high levels of efficiency to high-mix, low-volume production as well as high-volume operations. Compatible with our range of horizontal machining centers, Multi-Tasking machines and ORBITEC 20 machining center for large parts, the PALLETECH is available in single, double and triple level pallet stocker configurations. Because of its modular, pre-engineered construction, PALLETECH easily expands along with your growing business. In fact, it can accommodate up to 16 machines, 6 to 240 pallets and up to 8 loading stations.
A highly advanced alternative to traditional production, articulated robots provide automation for one or multiple machines as well as part transfers to peripheral operations. They also eliminate the challenges that come with handling large, heavy or cumbersome parts. Articulated robots use rotary joints to achieve an increased change of motion. From simple 2-joint robots to complex 10-joint robots, you have the power to choose just how much range of motion is necessary to gain the competitive advantage.
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