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Daily Archives: January 20, 2017
Atopic dermatitis – Wikipedia
Posted: January 20, 2017 at 11:44 pm
Atopic dermatitis (AD), also known as atopic eczema, is a type of inflammation of the skin (dermatitis). It results in itchy, red, swollen, and cracked skin. Clear fluid may come from the affected areas, which often thicken over time.[1] The condition typically starts in childhood with changing severity over the years.[1][2] In children under one year of age much of the body may be affected. As people get older, the back of the knees and front of the elbows are the most common areas affected. In adults the hands and feet are the most commonly affected areas.[2] Scratching worsens symptoms and affected people have an increased risk of skin infections. Many people with atopic dermatitis develop hay fever or asthma.[1]
The cause is unknown but believed to involve genetics, immune system dysfunction, environmental exposures, and difficulties with the permeability of the skin.[1][2] If one identical twin is affected, there is an 85% chance the other also has the condition.[3] Those who live in cities and dry climates are more commonly affected. Exposure to certain chemicals or frequent hand washing makes symptoms worse. While emotional stress may make the symptoms worse it is not a cause. The disorder is not contagious.[1] The diagnosis is typically based on the signs and symptoms. Other diseases that must be excluded before making a diagnosis include contact dermatitis, psoriasis, and seborrheic dermatitis.[2]
Treatment involves avoiding things that make the condition worse, daily bathing with application of a moisturising cream afterwards, applying steroid creams when flares occur, and medications to help with itchiness.[2] Things that commonly make it worse include wool clothing, soaps, perfumes, chlorine, dust, and cigarette smoke. Phototherapy may be useful in some people. Steroid pills or creams based on calcineurin inhibitors may occasionally be used if other measures are not effective.[1][4] Antibiotics (either by mouth or topically) may be needed if a bacterial infection develops.[2] Dietary changes are only needed if food allergies are suspected.[1]
Atopic dermatitis affects about 20% of people at some point in their lives.[1][5] It is more common in younger children.[2] Males and females are equally affected.[1] Many people outgrow the condition.[2] Atopic dermatitis is sometimes called eczema, a term that also refers to a larger group of skin conditions.[1] Other names include "infantile eczema", "flexural eczema", "prurigo Besnier", "allergic eczema", and "neurodermatitis".[6]
People with AD often have dry and scaly skin that spans the entire body, except perhaps the diaper area, and intensely itchy red, splotchy, raised lesions to form in the bends of the arms or legs, face, and neck.[7][8][9][10][11]
AD commonly occurs on the eyelids where signs such as Dennie-Morgan infraorbital fold, infra-auricular fissure, periorbital pigmentation can be seen.[12] Post-inflammatory hyperpigmentation on the neck gives the classic 'dirty neck' appearance. Lichenification, excoriation and erosion or crusting on the trunk may indicate secondary infection. Flexural distribution with ill-defined edges with or without hyperlinearily on the wrist, finger knuckles, ankle, feet and hand are also commonly seen.[13]
The cause of AD is not known, although there is some evidence of genetic factors, and some evidence that growing up in a sanitary environment encourages AD.[8]
It seems to have a genetic component. Many people with AD have a family history of atopy. Atopy is an immediate-onset allergic reaction (type 1 hypersensitivity reaction) as asthma, food allergies, AD or hay fever.[7][8] In 2006 it was discovered that mutations in the gene for the production of filaggrin strongly increased the risk for developing atopic dermatitis. Most importantly two mutations were found that affect approximately 5% of people in Western Europe that may disrupt the production of filaggrin. Filaggrin is a protein that plays an important role in the retention of water in the stratum corneum. People who have these mutations often have dry skin.[14] Filaggrin also plays an important role in keeping the skin surface slightly acidic, hence giving it anti-microbial effects. It breaks down into trans-urocanic acid, which keeps the pH low.[15]
According to the hygiene hypothesis, when children are brought up exposed to allergens in the environment at a young age, their immune system is more likely to tolerate them, while children brought up in a modern "sanitary" environment are less likely to be exposed to those allergens at a young age, and, when they are finally exposed, develop allergies. There is some support for this hypothesis with respect to AD.
Those exposed to dogs while growing up have a lower risk of atopic dermatitis.[16] There is also support from epidemiological studies for a protective role for helminths against AD.[17] Likewise children with poor hygiene are at a lower risk for developing AD, as are children who drink unpasteurised milk.[17] Exposure to dust mites is believed to contribute to one's risk of developing AD.[18]
A diet high in fruits seems to have a protective effect against AD, whereas the opposite seems true for fast foods.[17]
Atopic dermatitis sometimes appears associated with celiac disease and non-celiac gluten sensitivity.[19][20]
An atopy patch test can be used to determine whether or not a specific allergen is the cause of the rash. The test involves applying a series of allergens to the skin surface and evaluating the results in one to three days.[21][22]
People with atopic dermatitis are more likely to have Staphylococcus aureus living on them.[23]
There is no known cure for AD, although treatments may reduce the severity and frequency of flares.[7]
Applying moisturisers may prevent the skin from drying out and decrease the need for other medications.[24] Affected persons often report that improvement of skin hydration parallels with improvement in AD symptoms.[7]
Health professionals often recommend that persons with AD bathe regularly in lukewarm baths, especially in salt water, to moisten their skin.[8][25] Avoiding woollen clothing is usually good for those with AD. Likewise silk, silver-coated clothing may help.[25] Dilute bleach baths have also been reported effective at managing AD.[25]
Vitamin D is an effective treatment for AD.[26]
Studies have investigated the role of long chain polyunsaturated fatty acids (LCPUFA) supplementation and LCPUFA status in the prevention and treatment of atopic diseases, but the results are controversial. It remains unclear if the nutritional intake of n-3 fatty acids has a clear preventive or therapeutic role, or if n-6 fatty acids consumption promotes atopic diseases.[27]
Several probiotics seem to have a positive effect with a roughly 20% reduction in the rate of atopic dermatitis.[28] The best evidence is for multiple strains of bacteria.[29]
In people with celiac disease or non-celiac gluten sensitivity, a gluten free diet improves their symptoms and prevents the occurrence of new outbreaks.[19][20]
Topical corticosteroids, such as hydrocortisone have proven themselves effective in managing AD.[7][8] If topical corticosteroids and moisturisers fail, short-term treatment with topical calcineurin inhibitors like tacrolimus or pimecrolimus may be tried, although they are usually avoided as they can cause skin cancer or lymphoma.[7][30] Alternatively systemic immunosuppressants may be tried such as ciclosporin, methotrexate, interferon gamma-1b, mycophenolate mofetil and azathioprine.[7][31] Antidepressants and naltrexone may be used to control pruritus (itchiness).[32]
A more novel form of treatment involves exposure to broad or narrow-band ultraviolet (UV) light. UV radiation exposure has been found to have a localized immunomodulatory effect on affected tissues and may be used to decrease the severity and frequency of flares.[33][34] In particular, the usage of UVA1 is more effective in treating acute flares, whereas narrow-band UVB is more effective in long-term management scenarios.[35] However, UV radiation has also been implicated in various types of skin cancer, and thus UV treatment is not without risk.[36]
Since the beginning of the twentieth century, many mucosal inflammatory disorders have become more common; atopic eczema (AE) is a classic example of such a disease. It now affects 1530% of children and 210% of adults in developed countries and in the United States has nearly tripled in the past thirty to forty years.[8][37] Over 15 million American adults and children have atopic dermatitis.[38]
Evidence suggests that IL-4 is central in the pathogenesis of AD.[39] Therefore, there is a rationale for targeting IL-4 with anti-IL-4 inhibitors.[40]
Diseases of the skin and appendages by morphology
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Psoriasis – familydoctor.org
Posted: at 11:43 pm
How is psoriasis treated?
There are a number of treatments for psoriasis. Your doctor will help you decide which one is best for you. Keeping your skin moisturized with an over-the-counter product is a good first step. Body lotion can help keep skin from getting too dry and cracking. It can also help remove some of the scales. Bathing daily in Epsom salts, Dead Sea salts, bath oil or oatmeal can calm redness and remove scales.
Prescription creams, ointments, lotions and gels (also called topical medicines) that you put on the affected areas are often used to treat psoriasis. To help the medicine stay on the skin, you might apply it and then cover the areas with plastic wrap (such as Saran Wrap). Options include corticosteroids, a type of vitamin D and pine tar. Special shampoos are used for psoriasis on the scalp.
For more severe cases of psoriasis, your doctor may prescribe antibiotics or other medicines in pill form. Some of these medicines can cause side effects, so your doctor may prescribe these for only a short period of time before returning to another type of treatment.
Sunlight also can help psoriasis, but be careful not to stay in the sun too long. A sunburn can actually make your psoriasis worse. Talk to your doctor about how to safely try sunlight exposure as a psoriasis treatment. Light therapy may be another option for treatment of psoriasis. With this treatment, the affected skin is exposed to controlled forms of artificial sunlight, usually after using Psoralen, a light-sensitizing medicine. This is called PUVA treatment. Talk to your doctor about this option.
While psoriasis will typically improve with treatment, it may not ever completely go away. The scales of psoriasis should improve after you begin treatment. It may take 2 to 6 weeks for the affected areas of your skin to return to a more normal thickness, and the redness may take several months to improve. Sometimes, certain scaly spots will get better at the same time that other spots get worse.
After youve been using a certain type of medicine for a while, your psoriasis may get used to the treatment. If this happens, your medicine may not be as effective as it once was. Your doctor may change your medicine. Sometimes you may need a stronger dose of medicine. Talk to your doctor if your psoriasis doesnt seem to be getting better with treatment.
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Google, Singularity University futurist Ray Kurzweil on the …
Posted: at 11:40 pm
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Sep 6, 2016, 4:18pm PDT
Leia Parker Managing Editor Silicon Valley Business Journal
Leia Parker Managing Editor Silicon Valley Business Journal
Ray Kurzweil sees a future in which we can connect our brains to the cloud to augment our more
Vicki Thompson
Ray Kurzweil is a futurist, a director of engineering at Google and a co-founder of the Singularity University think tank at NASA Ames Research Center in Mountain View. He is a nonfiction author and creator of several inventions.
Kurzweil met with the Silicon Valley Business Journal to discuss how technology's exponential progress is rapidly reshaping our future through seismic shifts in information technology and computing power, energy, nanotechnology, robotics, health and longevity.
Ray Kurzweil sees a future in which we can connect our brains to the cloud to augment our more
Vicki Thompson
This Q&A interview has been edited for length and clarity.
You've written about the potential to greatly improve humans abilities through a fusion of technology with biology. Could you describe how youre trying to motivate people to make this happen?
I've tried to articulate where I see the technology going and the underlying force behind it, which I call the law of accelerating returns, and the enormous opportunities created by exponential growth of information technology. It's not intuitive our intuition about the future is linear. But the reality of information technology is, it's exponential.
Exponentials are quite seductive because they start out sub-linear. We sequenced one ten-thousandth of the human genome in 1990 and two ten-thousandths in 1991. Halfway through the genome project, 7 years into it, we had sequenced 1 percent. People said, "This is a failure. Seven years, 1 percent. It's going to take 700 years, just like we said." Seven years later it was done, because 1 percent is only seven doublings from 100 percent and it had been doubling every year. We don't think in these exponential terms. And that exponential growth has continued since the end of the genome project. These technologies are now thousands of times more powerful than they were 13 years ago, when the genome project was completed.
Most importantly, we will be able to reprogram this outdated software that runs in our bodies, through biotechnology. We're now seeing clinical implications: It's now a trickle. It'll be a flood over the next decade. We're literally going to be able to reprogram biology away from disease and away from aging.
People say, You know, my cell phone is literally billions of times more powerful per dollar than the computer I used when I was an undergraduate, but it only applies to these gadgets we carry around. Thats not the case. Its going to transform food, printing, manufacturing of housing and energy.
Solar energy is growing exponentially because we're applying nanotechnology to the construction of solar panels and energy storage. It's now 2 percent of the world's energy, so people dismiss it as: It's 2 percent. It's a nice thing to do. It's a fringe player. That's not going to solve the problem. They are ignoring the exponential growth. Two percent is only six doublings from 100 percent. We're doubling every two years. That's 12 years. We can meet all of our energy needs through solar.
When I talk about radical life extension through biotechnology and nanotechnology, you can say, "Yeah, but we're going to run out of resources." But the same technologies that are going to extend life are also going to expand resources.
Ultimately, we can produce food extremely inexpensively through vertical agriculture, and we'll be able to print out everything we need through 3D printing. It's not ready yet for prime time. We're kind of in the hype phase now.
By 2020, we'll have sub-micron resolutions. We'll be able to print out and begin a really revolutionized manufacturing. We'll be able to print out modules and snap them together, Lego style, for construction of houses and office buildings. It's already started in Asia. It's not cost-effective yet, but these technologies have a 50 percent deflation rate.
We'll be able to print out clothing for pennies per pound with 3D printing in the 2020s. And there will be an open-source market of designs that are extremely inexpensive.
How is the rapid increase in computing power democratizing access and changing our economy?
I had saved up for years from my paper route as a teenager to buy the Encyclopedia Britannica for $1,000. I thought it was fantastic. It had all these incredible articles about everything I could imagine. Well, now a kid in Africa with her $30 smartphone can access a much better encyclopedia for free, and that's one of thousands of free fantastic information resources that are at her fingertips.
This is all factored out of the economic statistics. They say, Well, economic growth is limited. That's because we put this growth in both the numerator and the denominator. This kid in Africa that spent $30 on a smartphone is walking around with a trillion dollars of computation and communication and other intellectual resources, circa 1968, and still only accounts for $30 of economic activity.
People say, Okay, these fantastic comparisons apply to this strange world of great devices. You can't eat that, you can't live in it, you can't wear it. All of that's going to change with 3D printing, with virtual reality, with all these other resources that are expanding exponentially, and they sneak up on us. When these things start out, they don't work. By the time they work, they've been around for a long time, and they kind of sneak up on us.
What is your current focus in your work at Google?
I am a director of engineering, and I'm heading up a team working on natural language understanding. Language is like our most important method of communication. All of human knowledge is embedded in language. When we expanded our neocortex two million years ago and we got these big foreheads, the first thing we did was invent language so I could take an idea in my head, which is a hierarchical set of symbols, and transmit it to your neocortex. We needed a hierarchical medium to do that communication, so we invented language.
Since then, we've invented billions of documents in language with all of our knowledge. If we could actually understand the meaning of documents, that would unlock this great world of knowledge to computation and ultimately to humans so we can have our computer programs actually understand what they're reading. And we've already made great strides in that.
What's your primary objective for your work at Google?
We're part of an effort working with other teams to move towards an actual understanding of documents. So a search would not just be looking for keywords, it would actually look for meaning, and language translation would be based on meaning. It's a long-term effort to really understand language. Google's motto is, "We organize the world's information." Well, the most important information if you write a blog post is: What are you trying to say? You're not just trying to put together an interesting collection of words. Google's not the only company working on this, but that's a grand challenge to actually understand the meaning of documents.
What occupies your mind the most right now? Is it machine learning or another area of interest?
Well, I've been very focused on artificial intelligence for 50 years. I actually met with the founders of artificial intelligence. Marvin Minsky, who became my mentor, was the father of the symbolic school of artificial intelligence. And then in '62, when I was 14, I met with Frank Rosenblatt, who's the founder of the connectionist school and neural nets. He invented the first neural net called the Perceptron, and I've been immersed in that field for more than 50 years.
At the same time, I'm a writer and a futurist, so I keep track of all the world's technologies and how they're interacting.
I've had a long-term interest in health, which comes from, for example, my father dying prematurely of heart disease. That interest just comes from being a human being with a version 1.0 biological body. But that now has become an information technology, because we've unlocked the information basis of biology, which is genes, and have the meanings of actually reprogramming this outdated software. This interest, which was not related to my interest in computer science, has become now a field of computer science.
You serve on the board of Martine Rothblatt's company, United Therapeutics. What is that company doing in this area of health?
Yes, I've been on the board since that company was founded in 1999. That's one very good example of biotechnology. I've written about this for a long time, but now it's becoming a reality. We can actually print out hearts, lungs, kidneys, and populate them with stem cells and grow out a human organ. This is being done successfully in animals. We can do it in humans now with simple organs, like tracheas and windpipes.
We can do it experimentally with animals with more complex organs, like kidneys, lungs and hearts. That will be coming to a human near you in five to 10 years, but it's happening. If you can do it in a primate, we know we can do it in a human. We have to go through the whole regulatory and safety process to perfect the technology, but it's coming.
Youve also written about the importance of brain mapping. How does that factor into technologys exponential progress?
I track brain reverse engineering very carefully. We can do noninvasive brain scanning in humans. We can actually see now single inter-neuronal connections forming in real time and firing in real time. And there are a lot of different parameters that are important: the speed with which you can do it, the bandwidth and how deeply into the brain you can go with noninvasive scanning. But all of these parameters are rapidly improving.
How important is understanding how the brain functions in order to develop better artificial intelligence?
To me, the importance of brain reverse engineering is not that we're going to copy exactly how the brain works in cell rhythms, but find out its basic principles of operation. Then we can use good engineering to create the same principles, but do it more quickly with electronics. Our neurons transmit information using electric chemical signals that travel a few hundred feet per second. Electronics are already millions of times faster than our neurons, but we need to understand the principles of how it works.
In my last book, How to Create a Mind, I talk about the evidence we already have on how our neocortex works. It organizes 300 million modules, each of which can learn and understand a pattern, and they're organized in hierarchies. We create that hierarchy with our own thinking, and there have been a lot of insights from the brain reverse engineering projects that really support this thesis.
You've given timelines for bringing on a transhuman reality, in which our capabilities are dramatically increased through the power of technology. How are we doing in keeping to those?
We're very much on schedule. Artificial intelligence itself has done remarkable things that people didn't expect to see for a long time, like drive cars, like play Go better than any human and understand language to some extent.
Jeopardy is a language game. Watson got a better score than the best two humans combined, and answered this query correct: A long, tiresome speech delivered by a frothy pie topping. It quickly said, "What is a meringue harangue?" That's pretty good. And Watson got its knowledge by reading Wikipedia and other encyclopedias. It doesn't read as well as you or I, but it reads a lot more documents. It read 200 million documents. We can't do that. It was able to combine all of its knowledge from that effort.
We're making tremendous progress on understanding the brain. I think we're very much on track to have human-level AI by 2029, which has been my consistent prediction for 20 years, and then to be able to send nanobots into the brain in the 2030s and connect our biological neocortex to synthetic neocortex in the cloud.
This is impressive by itself, but it's more impressive because it connects to the cloud. If you do speech recognition or intelligent search, it goes out to the cloud and makes itself a million times smarter. It does that without you even being aware of it. People don't even know it's happening.
We can't do that directly from our brains yet. We do it indirectly with our devices. We have to use our fingers and our eyes and so forth. Ultimately, we'll do it directly from our brain and not just do search and translation directly from our brain, but actually access synthetic neocortex. So just the way this [he holds up his smartphone] makes itself smarter by connecting to the cloud, we'll make ourselves smarter. And that's the ultimate application of artificial intelligence: to extend our mental reach. That's a 2030s scenario.
Your Singularity University co-founder Peter Diamandis has told me he believes that today, its possible for people to live long enough to live forever because of these rapid technological changes. Do you anticipate this could happen for you?
I'm planning on it. So far so good.
You're 68 years old now?
Yeah. And I could be hit by the proverbial bus tomorrow, but we're working on that, too, with self-driving cars.
What would it take to dramatically extend the lifespan of humans?
I think we're on the order of a dozen years away from a tipping point where we're adding more time through scientific progress than is going by. People say, You think you're going to live hundreds of years taking these supplements, and with your lifestyle and so on, that you describe in your book? And I say, No, the goal of that, which we call Bridge One, is just to get to Bridge Two, which is the biotechnology revolution. And a dozen years from now, we will really have arrested most disease and aging processes. Not all, but we'll reach a tipping point where we're adding more time than is going by.
And then Bridge Two will be a bridge to the nanotechnology revolution: medical nanorobots that can augment our immune system and go beyond our immune system. Our immune system evolved when it was not in the interest of the human species for us to live very long, so it did not select for long life. It doesn't work on cancer for example. So we can finish the job with medical nanorobots that can basically defeat all disease and aging processes. That's 20 years away.
How would that help to bring about a period of abundance?
Well, that will enable us to live longer. Then people say, "We're going to run out of resources." That's where abundance comes in. Solar energy is doubling every two years because we're applying nanotechnology. We're only six doublings from meeting all of our energy needs through solar. We have 10,000 times more sunlight than we need to do that with. We'll have 3D printing for modules to snap together and create a house, for food, for clothing. We'll meet our physical needs through 3D printing. We'll have virtual realities, so we won't have to travel as much. So ultimately, we will have an age of abundance we won't run out of resources.
What would people do with themselves?
We'll continue to create knowledge. What do we do now? Sixty-five percent of all jobs in the United States, Europe and Asia are information jobs. It didn't exist 25 years ago. So what if people are creating art for websites or creating music?
We have 15 million college students and 15 million people that service them. That's 30 million people. It was 65,000 college students in 1870, so we're moving up Maslow's hierarchy. We're doing more gratifying things: creating knowledge of beauty, like music and art, science, technology.
Are you worried about individuals' worst impulses potentially throwing a wrench into the works?
Well I think we're getting better because I think communication has democratized the world. You could count the number of democracies in the world on the fingers of one or two hands a century ago. You could count the numbers of democracies in the world two centuries ago on the fingers of one finger.
We certainly don't live in a perfect world, but this is the most peaceful time in human history. People say, "What are you kidding? Don't you pay attention to the news? Didn't you hear about the incident yesterday and a week ago?" Well that's the point. Our information about violence and what's wrong with the world is getting exponentially better. It could be a battle that wiped out a nearby village and you wouldn't even hear about it a century ago. Now, there's an incident and we not only hear about it, we're immersed in it, we experience it. That's painful, but it's actually a good thing because it motivates us to do something about it.
Steven Pinker's The Better Angels of Our Nature documents an exponential decline in violence. We rightfully get upset about incidents that kill tens, hundreds, thousands of people. You don't have to go back that far in history to see incidents that killed millions tens of millions of people. It's not like this type of violence and intolerance didn't exist. We just didn't actually have very good information about it a century or two ago.
Currently, we're in the political season, and weve seen plenty of polarization. Where do you stand with respect to the U.S. presidential election and how it has developed?
Technology is a double-edged sword, and it can also spread intolerance. I'm not happy with the level of intolerance that we see expressed in some parts of the political sphere. But I do think without commenting specifically on the current presidential race there's a world consensus on tolerance, equality, democracy, liberty, and then we complain about the extent we see things that don't live up to that. We're moving in the right direction. History is always a messy process, and we have much better information about the mess now than we ever did before.
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Psychedelics | Adonis Diaries
Posted: at 1:58 am
Psychedelics and Psychosis: Any links?
No Link Found between Psychedelics and Psychosis?
A large U.S. survey found that users of LSD and similar drugs were no more likely to have mental-health conditions than other respondents
Of those, 14% described themselves as having used at any point in their lives any of the three classic psychedelics: LSD, psilocybin (the active ingredient in so-called magic mushrooms) and mescaline (found in the peyote and San Pedro cacti).
The researchers found that individuals in this group were not at increased risk of developing 11 indicators of mental-health problems such as schizophrenia, psychosis, depression, anxiety disorders and suicide attempts.
Their paper appears in the March issue of theJournal of Psychopharmacology.
The findings are likely to raise eyebrows.
Fears that psychedelics can lead to psychosis date to the 1960s, with widespread reports of acid casualties in the mainstream news. But Krebs says that because psychotic disorders are relatively prevalent, affecting about one in 50 people, correlations can often be mistaken for causations.
Psychedelics are psychologically intense, and many people will blame anything that happens for the rest of their lives on a psychedelic experience.
The three substances Johansen and Krebs looked at all act through the brains serotonin 2A receptor.
The authors did not include ketamine, PCP, MDMA, fly agaric mushrooms, DMT or other drugs that fall broadly into the category of hallucinogens, because they act on other receptors and have different modes of biochemical action.
Ketamine and PCP, for example, act on the NMDA receptor and are both known to be addictive and to cause severe physical harms, such as damage to the bladder.
Absolutely, people can become addicted to drugs like ketamine or PCP, and the effects can be very destructive. We restricted our study to the classic psychedelics to clarify the findings, says Johansen.
The acid casualty myth This study assures us that there were not widespread acid casualties in the 1960s, says Charles Grob, a paediatric psychiatrist at the University of California, Los Angeles. He has long has advocated the therapeutic use of psychedelics, such as administering psilocybin to treat anxiety in terminal-stage cancer. But he has concerns about Krebs and Johansens overall conclusions, he says, because individual cases of adverse effects use can and do occur.
For example, people may develop hallucinogen persisting perception disorder (HPPD), a trip that never seems to end, involving incessant distortions in the visual field, shimmering lights and coloured dots. Ive seen a number of people with these symptoms following a psychedelic experience, and it can be a very serious condition, says Grob.
Krebs and Johansen, however, point to studies that have found symptoms of HPPD in people who have never used psychedelics.
The second of the new two studies, also published in theJournal of Psychopharmacology, looked at 190,000 NSDUH respondents from 2008 to 2012.
It also found that the classic psychedelics were not associated with adverse mental-health outcomes. In addition, it found that people who had used LSD and psilocybin had lower lifetime rates of suicidal thoughts and attempts.
We are not claiming that no individuals have ever been harmed by psychedelics, says author Matthew Johnson, an associate professor in the Behavioral Pharmacology Research Unit at Johns Hopkins University in Baltimore, Maryland.
Anecdotes about acid casualties can be very powerfulbut these instances are rare, he says.
At the population level, he says, the data suggest that the harms of psychedelics have been overstated.
This article is reproduced with permission and was first published on March 4, 2015.
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US court says PSN data doesnt get Fourth Amendment …
Posted: at 1:48 am
Aurich x Getty
If you have any legally incriminating information sitting in your PSN account, don't count on the Fourth Amendment to protect it from "unreasonable search and seizure" by Sony without a warrant. A district court judge in Kansas has ruledin a recent case that information Sony finds has been downloaded to a PlayStation 3 or a PSN account is not subject to the "reasonable expectation of privacy" that usually protects evidence obtained without a warrant.
The case involves Michael Stratton, who went by the handle Susan_14 on PSN. According to Sony, Stratton was reported to PSN multiple times for sending spam messages asking about interest in child pornography. After reviewing the Susan_14 account in response to these complaints, Sony found that several images containing child porn had been downloaded by and uploaded to the account.
Sony shared information about the Susan_14 account and the images with the National Center for Missing and Exploited Children. The NCMEC then coordinated with the FBI to get additional information about Susan_14's e-mail address and IP address from Google and CenturyLink via subpoena. This action led to a warrant on Stratton's Kansas home, the discovery of child pornography stored on his PS3, and his arrest.
At trial, the defense tried to argue that Stratton had a "reasonable expectation of privacy" for the images on his PSN account and that Sony therefore couldn't share those with authorities absent a subpoena or warrant. In this case, the court ruled that Sony's PSN terms of service "explicitly nullified its users reasonable expectation of privacy." Those terms state explicitly that Sony reserves the right to monitor PSN activity and that Sony may turn over evidence of illegal activity to the authorities.
(The defense also made the related argument that Sony's terms of service were an adhesion contract that put an "unconscionable" and "patently unfairly... take-it-or-leave-it" burden on Stratton. The defense didn't provide enough evidence to demonstrate that claim, according to the court.)
Separately, the defense argued that Sony was acting as a "government agent" when it searched Stratton's PSN account, and, therefore, any evidence obtained needed to be subject to a warrant. This argument hinges in part on the federal "Failure to Report Child Abuse" statute, which requires those that learn of child abuse to "make a timely report" or suffer jail time or fines. Through this law, the defense argued, Sony was essentially being recruited to search for child pornography at the government's request and without any warrant.
The case is not all that different from other cases in which online service providers have worked with law enforcement to report child pornography when found on their services or devices. The main difference here is that the circuit court has found that these same legal arguments apply to the tightly controlled world of the PlayStation 3 and the attached PlayStation Network and not just the more "open" world of personal computers.
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Elon Musk lays out SpaceX’s incredible plan for colonizing …
Posted: at 1:45 am
SpaceX successfully tested its Raptor interplanetary drive prototype this week, but that was only a hint of what SpaceX has planned. On Tuesday, founder Elon Musk took the stage at the International Astronautical Congress (IAC) to explain how SpaceX plans to make humanity a multi-planetary species. There are still some unanswered questions. But by focusing on fuel efficiency and reusable rocket design, Musk says he believes almost anyone will be able to go to the Red Planet and build a new society.
Before he got into talking about the Interplanetary Transport System, Musk explained why Mars would be the ideal target for human colonization efforts instead of the moon, for instance. While Mars is smaller than the Earth, it still has enough gravity for people to live and work in a similar way to how they do on Earth. The mineral wealth on Mars is also greater than what youd find on the moon. In addition, Mars has an atmosphere, although its very thin.
By increasing the temperature of Mars, Musk says the atmosphere could be thickened and enriched with oxygen. We already know theres plenty of frozen water on Mars, so increasing the temperature could result in liquid oceans. The carbon dioxide atmosphere Mars currently has could easily be compressed to grow plant life as well. Taken together, that makes Mars feasible for a self-sufficient human colony.
The technology technically exists to go to Mars because it is fairly close in astronomical terms. But its extremely expensive. A scaled up Apollo-style mission would cost about $10 billion per person transported. SpaceX plans to develop a fleet of reusable vehicles and can be refueled in orbit. With the right systems in place. SpaceX believes it can get the cost of a ticket to Mars down to $200,000, but this isnt an extravagant vacation youd pay $200,000 to start a new life on Mars after selling most of your possessions on Earth (cargo space is limited). Over time, that price might come down to as little as $100,000.
Its not clear what sort of training would be needed for the mission, but Musk said it probably wouldnt be much. Will those with health concerns be allowed to go? Will the colonists own land on Mars? The gravity on Mars is much lower, so will people be able to return to Earth with its high gravity after living on Mars? We dont know the answer to any of these questions yet.
The Interplanetary Transport System would be multi-stage, but the first stage is designed toland itself back on Earth after getting the spacecraft into orbit, just like the Falcon 9. This booster ispowered by 42 Raptor engines for 13,000 tons of liftoff thrust. Due to its size, the first launches will take place on the original Apollo 39A launchpad at Kennedy Space Center.
After its in orbit, several tankers of a similar design will be sent up to refuel the ship before it begins its Mars journey. Upon its arrival, the ship will land propulsively on the surface to drop off colonists and supplies. SpaceX chose to go with a methane fuel for the Raptor because thats easier to make on Mars. The ships that deliver people wont just sit there theyll be refueled and sent back to Earth. This will also allow colonists who have a change of heart to return to Earth.
The ITS passenger ship.
Musk says that the Interplanetary Transport System will take 100 to 200 people to Mars at a time, and the journey could take as little as 80 to 90 days. There are launch windows to Mars every few years, and SpaceX wants to have fleets of multiple ships ready to go for each one. In a few decades, there could be a million people on Mars, which would be enough to make it self-sufficient.
SpaceX plans to start launching to Mars in the next year or two with Falcon 9 Heavy rockets and Dragon 2 landers. This will serve as the first phase of testing for the colonization efforts. The Interplanetary Transport System should begin orbital testing around 2020, and SpaceX wants to send it on test flights to Mars in the early 2020s.
Thats a very aggressive timetable, and we dont have any information regarding how colonists would work to warm Mars or protect themselves from radiation. We might learn more as SpaceX begins transporting materials and supplies to Mars on the Dragon landers. Musk wants to have a Mars mission planned for every launch window to begin laying the groundwork for human habitation.
Theres still a lot that could go wrong. But colonizing Mars has never felt so real.
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