Daily Archives: January 14, 2017

Noopept | Smarter Nootropics

Posted: January 14, 2017 at 9:04 pm

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GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester, , (CAS Number) 157115-85-0, (PubChem) CID 180496, C17H22N2O4

Among the studies cited, the effective doses ranged from .01mg/kg to 10 mg/kg (in rats and mice); when subjected to allometric scaling, this range would be equivalent to .002mg/kg to 2.445 mg/kg in humans [7,10,13]. In a 70kg (154lbs) adult human, the dosing range would be 171mcg to 171mg.

Typically, the most cited dosing range (anecdotally) is 10-30mg, up to 3 times per day, usually dosed sublingually or orally.

Patented in 1995, Noopept is a Nootropic substance that is a dipeptide similar in effect to Piracetam [3]; it is often cited as being 1000 times more potent (by weight) than Piracetam. Noopept has high oral bioavailability, and appears to potentiate its own effects with chronic administration. Noopept has shown promise in treating many different aspects of cognitive decline that warrants more research, especially in human models.

Noopept has been noted to have four main mechanisms of action; the first noted mechanism of action is antioxidation: in vitro studies of Noopept have shown signs that it operates on an antioxidative mechanism of action which protects neurons from apoptosis [4]. The second noted mechanism of action of Noopept is inhibition of glutamate neurotoxicity [1]; glutamate neurotoxicity leads to quick cell death, and is linked to a variety of neurological disorders such as autism and Alzheimers disease. The third mechanism of action of Noopept is increased neuronal plasticity [7], which can lead to greater adaptability in learning and memory. The fourth mechanism of action that has been noted in Noopept is increases expression of phenylacetic acid, prolyglycine, and cyclo-prolyglycine in the brain [12], which are endogenous Nootropics.

What makes Noopept an intriguing nootropic is its myriad of positive effects, lack of noted negative side effects, and its effectiveness in both chronic and acute usage. In both in vivo and in vitro models, Noopept was shown to have positive effects on all stages of memory, from learning to recall, as well as anxiolytic effects [1]. An in vitro study showed Noopept to be neuroprotective against the use of H2O2 in neuronal degradation, in both healthy brains as well as those with Downs Syndrome in a dose-dependent manner [4]. In rat models of memory impairment, Noopept was shown to improve memory retention and retrieval, and improve learning which was shown through the use of passive avoidance response testing [6]. Rats with ischemic lesions were treated with Noopept for nine days and then tested with the passive avoidance test; those rats that had been treated performed significantly better than the control group; Noopept was also shown to be neuroprotective through antioxidation in the rats who received treatment for nine days [7]. Studies also showed that rats given a single oral administration of Noopept showed improved scores on the passive avoidance test [10]. Another study showed that rats who had gone through olfactory bulbectomies showed Alzheimers like symptoms, but after 21 days of dosing Noopept, spatial memory improved greatly which was evidenced through the use of the Morris Water Maze test [13].

Two other interesting benefits of Noopept were noted; one dealing with BDNF and NGF, and the other dealing with the immune system. One study showed rats treated with Noopept, both chronically and acutely, were found to have a higher expression of mRNA BDNF and NGF; even more interestingly, after 28 days of treatment no tolerance towards Noopept was detected and there was some evidence the effects of Noopept potentiate the longer it is administered [8]. Another study looked at the effect of Noopept on immune deficient mice; the researchers found Noopept to have immuno-corrective properties [5].

Among the studies cited, doses up to 10mg/kg in rats have shown no toxicity, which when subjected to allometric scaling yields a dose of 2.445mg/kg in humans (or 171 mg for a 70kg person); in fact, Noopept has been shown to be neuroprotective at said dosage [7,10,13].

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Ostrovskaia RU, Gudasheva TA, Voronina TA, Seredenin SB. The original novel nootropic and neuroprotective agent noopept. Eksp Klin Farmakol. 2002 Sep-Oct;65(5):66-72. [1]

Neznamov GG, Teleshova ES. Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin. Neuroscience and Behavioral Physiology Volume 39, Issue 3 , pp 311-321. [2]

SEREDENIN SERGEI B, VORONINA TATIANA A, GUDASHEVA TATIANA A, OSTROVSKAYA RITA U,

ROZANTSEV GRIGORI G, SKOLDINOV ALEXANDER P, TROPHIMOV SERGEI S, HALIKAS JAMES A, GARIBOVA TAISIJA L. Biologically active n-acylprolydipeptides having antiamnestic, antihypoxic and anorexigenic effects. US5439930 (A) 1995-08-08. [3]

Alejandra P, Hoyo-Vadillo C, Gudasheva T, Serednin S, Ostrovskaya R, Busciglio J. GVS-111 prevents oxidative damage and apoptosis in normal and Downs Syndrome human cortical neurons. International Journal of Developmental Neuroscience, Vol 21 Issue 3 May 2003 Pages 117-124. [4]

Kovalenko, Shipaeva, Alekseeva, Pronin, Durnev, Gudasheva, Ostrovskaja, Seredenin. Immunopharmacological properties of noopept. Bulletin of Experimental Biology and Medicine Volume 144, Issue 1 , pp 49-52. [5]

G. A. Romanova, F. M. Shakova, T. A. Gudasheva, R. U. Ostrovskaya. Impairment of Learning and Memory after Photothrombosis of the Prefrontal Cortex in Rat Brain: Effects of Noopept. Bulletin of Experimental Biology and Medicine Volume 134, Issue 6 , pp 528-530. [6]

Ostrovskaya R, Romanova G, Barskov I, Shanina E, Gudasheva T, Victorov I, Voronina T, Seredenin S. Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model. Behavioural Pharmacology: September 1999. [7]

R. U. Ostrovskaya, T. A. Gudasheva, A. P. Zaplina, Ju. V. Vahitova, M. H. Salimgareeva, R. S. Jamidanov, S. B. Seredenin. Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bulletin of Experimental Biology and Medicine Volume 146, Issue 3 , pp 334-337. [8]

S. S. Boiko, R. U. Ostrovskaya, V. P. Zherdev, S. A. Korotkov, T. A. Gudasheva, T. A. Voronina, S. B. Seredenin. Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration. Bulletin of Experimental Biology and Medicine Volume 129, Issue 4 , pp 359-361. [9]

R. U. Ostrovskaya, T. Kh. Mirsoev, G. A. Romanova, T. A. Gudasheva, E. V. Kravchenko, C. C. Trofimov, T. A. Voronina, S. B. Seredenin. Proline-Containing Dipeptide GVS-111 Retains Nootropic Activity after Oral Administration. Bulletin of Experimental Biology and Medicine Volume 132, Issue 4 , pp 959-962. [10]

Solntseva E, Bukanova J, Ostrovskaya R, Gudasheva T, Voronina T, Skrebitsky V. The effects of piracetam and its novel dipeptide analogue GVS-111 on neuronal voltage-gated calcium and potassium channels. General Pharmacology: The Vascular System, Volume 29 Issue 1, July 1997. [11]

T. A. Gudasheva, S. S. Boyko, R. U. Ostrovskaya, T. A. Voronina, V. K. Akparov, S. S. Trofimov, G. G. Rozantsev, A. P. Skoldinov, V. P. Zherdev, S. B. Seredenin. The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclol-prolylglycine. European Journal of Drug Metabolism and Pharmacokinetics Volume 22, Issue 3 , pp 245-252. [12]

Ostrovskaya RU, Gruden MA, Bobkova NA, Sewell RD, Gudasheva TA, Samokhin AN, Seredinin SB, Noppe W, Sherstnev VV, Morozova-Roche LA. The nootropic and neuroprotective prolinecontaining dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimers disease model. J Psychopharmacol August 2007 vol. 21 no. 6 611-61

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About Neurotechnology: company information and white paper

Posted: at 9:02 pm

Neurotechnology provides algorithms and software development products for biometric fingerprint, face, iris, voice and palm print recognition, computer-based vision and object recognition to security companies, system integrators and hardware manufacturers. More than 3,000 system integrators and sensor providers in more than 100 countries license and integrate company's technology into their own products.

With millions of customer installations worldwide, Neurotechnology's products are used for both civil and forensic applications, including border crossings, criminal investigations, systems for voter registration, verification and duplication checking, passport issuance and other national-scale projects.

Drawing from years of academic research in the fields of neuroinformatics, image processing and pattern recognition, Neurotechnology was founded in 1990 in Vilnius, Lithuania under the name Neurotechnologija and released its first fingerprint identification system in 1991. Since that time the company has released more than 130 products and version upgrades for identification and verification of objects and personal identity.

With a combination of fast algorithms and high reliability, company's fingerprint, face, eye iris and voice biometric technologies can be used for access control, computer security, banking, time attendance control and law enforcement applications, among others.

Neurotechnology's fingerprint identification algorithm has shown one of the best results for reliability in several biometric competitions, including the International Fingerprint Verification Competition (FVC2006, FVC2004, FVC2002 and FVC2000) and the National Institute of Standards & Technology (NIST) Fingerprint Vendor Technology Evaluation for the US Department of Justice (FpVTE 2003), where Neurotechnology ranked among the top five companies for accuracy in single-finger tests.

The company's MegaMatcher fingerprint identification engine has been recognized by NIST as fully MINEX compliant allowing to use it in U.S. Government Personal Identity Verification program (PIV) fingerprint recognition applications.

VeriEye iris identification engine has been tested in the NIST Iris Exchange (IREX) Evaluation and recognized as one of the most reliably accurate iris recognition algorithms among those tested.

In 2004 Neurotechnology began research in artificial intelligence (A.I.), computer vision and mobile autonomous robotics fields, and in the same year the company's AI division was founded. The company's object recognition, surveillance, eye movement tracking and 3D object model reconstruction technologies use advanced computer-based vision algorithms and are applicable to a variety of applications, as well as for generic robot and machine vision.

In 2014 Neurotechnology released SentiBotics a ready-to-use robotics development kit. SentiBotics enables the rapid development and testing of mobile robots and comes with software, sample programs, a tracked platform and grasping robotic arm, 3D vision, object recognition and autonomous navigation capabilities. The kit includes a mobile robotic platform with a 3D vision system, modular robotic arm and accompanying Neurotechnology-developed, ROS-based software with complete source code and programming samples.

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Singularitarianism | Prometheism.net | Futurist Transhuman …

Posted: at 8:56 pm

Ray Kurzweil is a genius. One of the greatest hucksters of the age. Thats the only way I can explain how his nonsense gets so much press and has such a following. Now he has the cover of Time magazine, and an article called 2045: The Year Man Becomes Immortal. It certainly couldnt be taken seriously anywhere else; once again, Kurzweil wiggles his fingers and mumbles a few catchphrases and upchucks a remarkable prediction, that in 35 years (a number dredged out of his compendium of biased estimates), Man (one, a few, many? How? He doesnt know) will finally achieve immortality (seems to me youd need to wait a few years beyond that goal to know if it was true). Now weve even got a name for the Kurzweil delusion: Singularitarianism.

Theres room inside Singularitarianism for considerable diversity of opinion about what the Singularity means and when and how it will or wont happen. But Singularitarians share a worldview. They think in terms of deep time, they believe in the power of technology to shape history, they have little interest in the conventional wisdom about anything, and they cannot believe youre walking around living your life and watching TV as if the artificial-intelligence revolution were not about to erupt and change absolutely everything. They have no fear of sounding ridiculous; your ordinary citizens distaste for apparently absurd ideas is just an example of irrational bias, and Singularitarians have no truck with irrationality. When you enter their mind-space you pass through an extreme gradient in worldview, a hard ontological shear that separates Singularitarians from the common run of humanity. Expect turbulence.

Wow. Sounds just like the Raelians, or Hercolubians, or Scientologists, or any of the modern New Age pseudosciences that appropriate a bit of jargon and blow it up into a huge mythology. Nice hyperbole there, though. Too bad the whole movement is empty of evidence.

One of the things I do really despise about the Kurzweil approach is their dishonest management of critics, and Kurzweil is the master. He loves to tell everyone whats wrong with his critics, but he doesnt actually address the criticisms.

Take the question of whether computers can replicate the biochemical complexity of an organic brain. Kurzweil yields no ground there whatsoever. He does not see any fundamental difference between flesh and silicon that would prevent the latter from thinking. He defies biologists to come up with a neurological mechanism that could not be modeled or at least matched in power and flexibility by software running on a computer. He refuses to fall on his knees before the mystery of the human brain. Generally speaking, he says, the core of a disagreement Ill have with a critic is, theyll say, Oh, Kurzweil is underestimating the complexity of reverse-engineering of the human brain or the complexity of biology. But I dont believe Im underestimating the challenge. I think theyre underestimating the power of exponential growth.

This is wrong. For instance, I think reverse-engineering the general principles of a human brain might well be doable in a few or several decades, and I do suspect that well be able to do things in ten years, 20 years, a century that I cant even imagine. I dont find Kurzweil silly because Im blind to the power of exponential growth, but because:

Kurzweil hasnt demonstrated that there is exponential growth at play here. Ive read his absurd book, and his data is phony and fudged to fit his conclusion. He cheerfully makes stuff up or drops data that goes against his desires to invent these ridiculous charts.

Im not claiming he underestimates the complexity of the brain, Im saying he doesnt understand biology, period. Handwaving is not enough if hes going to make fairly specific claims of immortality in 35 years, there had better be some understanding of the path that will be taken.

There is a vast difference between grasping a principle and implementing the specifics. If we understand how the brain works, if we can create a computer simulation that replicates and improves upon the function of our brain, that does not in any way imply that my identity and experiences can be translated into the digital realm. Again, Kurzweil doesnt have even a hint of a path that can be taken to do that, so he has no basis for making the prediction.

Smooth curves that climb upward into infinity can exist in mathematics (although Kurzweils predictions dont live in state of rigor that would justify calling them mathematical), but they dont work in the real world. There are limits. Weve been building better and more powerful power plants for aircraft for a century, but they havent gotten to a size and efficiency to allow me to fly off with a personal jetpack. I have no reason to expect that they will, either.

While I dont doubt that science will advance rapidly, I also expect that the directions it takes will be unpredictable. Kurzweil confuses engineering, where you build something to fit a predetermined set of specifications, with science, in which you follow the evidence wherever it leads. Look at the so-called war on cancer: it isnt won, no one expects that it will be, but what it has accomplished is to provide limited success in improving health and quality of life, extending survival times, and developing new tools for earlier diagnosis thats reality, and understanding reality is achieved incrementally, not by sudden surges in technology independent of human effort. It also generates unexpected spinoffs in deeper knowledge about cell cycles, signaling, gene regulation, etc. The problems get more interesting and diverse, and its awfully silly of one non-biologist in 2011 to try to predict what surprises will pop out.

Kurzweil is a typical technocrat with limited breadth of knowledge. Imagine what happens IF we actually converge on some kind of immortality. Who gets it? If its restricted, what makes Kurzweil think he, and not Senator Dumbbum who controls federal spending on health, or Tycoon Greedo the trillionaire, gets it? How would the world react if such a capability were available, and they (or their dying mother, or their sick child) dont have access? What if its cheap and easy, and everyone gets it? Kurzweil is talking about a technology that would almost certainly destroy every human society on the planet, and he treats it as blithely as the prospect of getting new options for his cell phone. In case he hadnt noticed, human sociology and politics shows no sign of being on an exponential trend towards greater wisdom. Yeah, expect turbulence.

Hes guilty of a very weird form of reductionism that considers a human life can be reduced to patterns in a computer. I have no stock in spiritualism or dualism, but we are very much a product of our crude and messy biology we percieve the world through imprecise chemical reactions, our brains send signals by shuffling ions in salt water, our attitudes and reactions are shaped by chemicals secreted by glands in our guts. Replicating the lightning while ignoring the clouds and rain and pressure changes will not give you a copy of the storm. It will give you something different, which would be interesting still, but its not the same.

Kurzweil shows other signs of kookery. Two hundred pills a day? Weekly intravenous transfusions? Drinking alkalized water because hes afraid of acidosis? The man is an intelligent engineer, but hes also an obsessive crackpot.

Oh, well. Ill make my own predictions. Magazines will continue to praise Kurzweils techno-religion in sporadic bursts, and followers will continue to gullibly accept what he says because it is what they wish would happen. Kurzweil will die while brain-uploading and immortality are still vague dreams; he will be frozen in liquid nitrogen, which will so thoroughly disrupt his cells that even if we discover how to cure whatever kills him, there will be no hope of recovering the mind and personality of Kurzweil from the scrambled chaos of his dead brain. 2045 will come, and those of us who are alive to see it, will look back and realize it is very, very different from what life was like in 2011, and also very different from what we expected life to be like. At some point, I expect artificial intelligences to be part of our culture, if we persist; theyll work in radically different ways than human brains, and they will revolutionize society, but I have no way of guessing how. Ray Kurzweil will be forgotten, mostly, but records of the existence of a strange shaman of the circuitry from the late 20th and early 21st century will be tucked away in whatever the future databases are like, and people and machines will sometimes stumble across them and laugh or zotigrate and say, How quaint and amusing!, or whatever the equivalent in the frangitwidian language of the trans-entity circumsolar ansible network might be.

And thatll be kinda cool. I wish I could live to see it.

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Euthanasia – Wikipedia

Posted: at 8:13 am

This article is about euthanasia of humans. For mercy killings performed on other animals, see Animal euthanasia.

Euthanasia (from Greek: ; "good death": , eu; "well" or "good" , thanatos; "death") is the practice of intentionally ending a life in order to relieve pain and suffering.[1]

There are different euthanasia laws in each country. The British House of Lords Select Committee on Medical Ethics defines euthanasia as "a deliberate intervention undertaken with the express intention of ending a life, to relieve intractable suffering".[2] In the Netherlands and Flanders, euthanasia is understood as "termination of life by a doctor at the request of a patient".[3]

Euthanasia is categorized in different ways, which include voluntary, non-voluntary, or involuntary. Voluntary euthanasia is legal in some countries. Non-voluntary euthanasia (patient's consent unavailable) is illegal in all countries. Involuntary euthanasia (without asking consent or against the patient's will) is also illegal in all countries and is usually considered murder.[4] As of 2006, euthanasia is the most active area of research in contemporary bioethics.[5]

In some countries there is a divisive public controversy over the moral, ethical, and legal issues of euthanasia. Those who are against euthanasia may argue for the sanctity of life, while proponents of euthanasia rights emphasize alleviating suffering, and preserving bodily integrity, self-determination, and personal autonomy.[6] Jurisdictions where euthanasia is legal include the Netherlands, Canada,[7]Colombia, Belgium, and Luxembourg.

Like other terms borrowed from history, "euthanasia" has had different meanings depending on usage. The first apparent usage of the term "euthanasia" belongs to the historian Suetonius, who described how the Emperor Augustus, "dying quickly and without suffering in the arms of his wife, Livia, experienced the 'euthanasia' he had wished for."[8] The word "euthanasia" was first used in a medical context by Francis Bacon in the 17th century, to refer to an easy, painless, happy death, during which it was a "physician's responsibility to alleviate the 'physical sufferings' of the body." Bacon referred to an "outward euthanasia"the term "outward" he used to distinguish from a spiritual conceptthe euthanasia "which regards the preparation of the soul."[9]

In current usage, euthanasia has been defined as the "painless inducement of a quick death".[10] However, it is argued that this approach fails to properly define euthanasia, as it leaves open a number of possible actions which would meet the requirements of the definition, but would not be seen as euthanasia. In particular, these include situations where a person kills another, painlessly, but for no reason beyond that of personal gain; or accidental deaths that are quick and painless, but not intentional.[11][12]

Another approach incorporates the notion of suffering into the definition.[11] The definition offered by the Oxford English Dictionary incorporates suffering as a necessary condition, with "the painless killing of a patient suffering from an incurable and painful disease or in an irreversible coma",[13] This approach is included in Marvin Khol and Paul Kurtz's definition of it as "a mode or act of inducing or permitting death painlessly as a relief from suffering".[14] Counterexamples can be given: such definitions may encompass killing a person suffering from an incurable disease for personal gain (such as to claim an inheritance), and commentators such as Tom Beauchamp and Arnold Davidson have argued that doing so would constitute "murder simpliciter" rather than euthanasia.[11]

The third element incorporated into many definitions is that of intentionality the death must be intended, rather than being accidental, and the intent of the action must be a "merciful death".[11] Michael Wreen argued that "the principal thing that distinguishes euthanasia from intentional killing simpliciter is the agent's motive: it must be a good motive insofar as the good of the person killed is concerned."[15] Similarly, Heather Draper speaks to the importance of motive, arguing that "the motive forms a crucial part of arguments for euthanasia, because it must be in the best interests of the person on the receiving end."[12] Definitions such as that offered by the House of Lords Select Committee on Medical Ethics take this path, where euthanasia is defined as "a deliberate intervention undertaken with the express intention of ending a life, to relieve intractable suffering."[2] Beauchamp and Davidson also highlight Baruch Brody's "an act of euthanasia is one in which one person... (A) kills another person (B) for the benefit of the second person, who actually does benefit from being killed".[16]

Draper argued that any definition of euthanasia must incorporate four elements: an agent and a subject; an intention; a causal proximity, such that the actions of the agent lead to the outcome; and an outcome. Based on this, she offered a definition incorporating those elements, stating that euthanasia "must be defined as death that results from the intention of one person to kill another person, using the most gentle and painless means possible, that is motivated solely by the best interests of the person who dies."[17] Prior to Draper, Beauchamp and Davidson had also offered a definition that includes these elements. Their definition specifically discounts fetuses in order to distinguish between abortions and euthanasia:[18]

"In summary, we have argued... that the death of a human being, A, is an instance of euthanasia if and only if (1) A's death is intended by at least one other human being, B, where B is either the cause of death or a causally relevant feature of the event resulting in death (whether by action or by omission); (2) there is either sufficient current evidence for B to believe that A is acutely suffering or irreversibly comatose, or there is sufficient current evidence related to A's present condition such that one or more known causal laws supports B's belief that A will be in a condition of acute suffering or irreversible comatoseness; (3) (a) B's primary reason for intending A's death is cessation of A's (actual or predicted future) suffering or irreversible comatoseness, where B does not intend A's death for a different primary reason, though there may be other relevant reasons, and (b) there is sufficient current evidence for either A or B that causal means to A's death will not produce any more suffering than would be produced for A if B were not to intervene; (4) the causal means to the event of A's death are chosen by A or B to be as painless as possible, unless either A or B has an overriding reason for a more painful causal means, where the reason for choosing the latter causal means does not conflict with the evidence in 3b; (5) A is a nonfetal organism."[19]

Wreen, in part responding to Beauchamp and Davidson, offered a six-part definition:

"Person A committed an act of euthanasia if and only if (1) A killed B or let her die; (2) A intended to kill B; (3) the intention specified in (2) was at least partial cause of the action specified in (1); (4) the causal journey from the intention specified in (2) to the action specified in (1) is more or less in accordance with A's plan of action; (5) A's killing of B is a voluntary action; (6) the motive for the action specified in (1), the motive standing behind the intention specified in (2), is the good of the person killed."[20]

Wreen also considered a seventh requirement: "(7) The good specified in (6) is, or at least includes, the avoidance of evil", although as Wreen noted in the paper, he was not convinced that the restriction was required.[21]

In discussing his definition, Wreen noted the difficulty of justifying euthanasia when faced with the notion of the subject's "right to life". In response, Wreen argued that euthanasia has to be voluntary, and that "involuntary euthanasia is, as such, a great wrong".[21] Other commentators incorporate consent more directly into their definitions. For example, in a discussion of euthanasia presented in 2003 by the European Association of Palliative Care (EPAC) Ethics Task Force, the authors offered: "Medicalized killing of a person without the person's consent, whether nonvoluntary (where the person in unable to consent) or involuntary (against the person's will) is not euthanasia: it is murder. Hence, euthanasia can be voluntary only."[22] Although the EPAC Ethics Task Force argued that both non-voluntary and involuntary euthanasia could not be included in the definition of euthanasia, there is discussion in the literature about excluding one but not the other.[21]

Euthanasia may be classified according to whether a person gives informed consent into three types: voluntary, non-voluntary and involuntary.[23][24]

There is a debate within the medical and bioethics literature about whether or not the non-voluntary (and by extension, involuntary) killing of patients can be regarded as euthanasia, irrespective of intent or the patient's circumstances. In the definitions offered by Beauchamp and Davidson and, later, by Wreen, consent on the part of the patient was not considered as one of their criteria, although it may have been required to justify euthanasia.[11][25] However, others see consent as essential.

Euthanasia conducted with the consent of the patient is termed voluntary euthanasia. Active voluntary euthanasia is legal in Belgium, Luxembourg and the Netherlands. Passive voluntary euthanasia is legal throughout the U.S. per Cruzan v. Director, Missouri Department of Health. When the patient brings about his or her own death with the assistance of a physician, the term assisted suicide is often used instead. Assisted suicide is legal in Switzerland and the U.S. states of California, Oregon, Washington, Montana and Vermont.

Euthanasia conducted when the consent of the patient is unavailable is termed non-voluntary euthanasia. Examples include child euthanasia, which is illegal worldwide but decriminalised under certain specific circumstances in the Netherlands under the Groningen Protocol.

Euthanasia conducted against the will of the patient is termed involuntary euthanasia.

Voluntary, non-voluntary and involuntary euthanasia can all be further divided into passive or active variants.[26] Passive euthanasia entails the withholding of common treatments, such as antibiotics, necessary for the continuance of life.[2] Active euthanasia entails the use of lethal substances or forces, such as administering a lethal injection, to kill and is the most controversial means. While some authors consider these terms to be misleading and unhelpful, they are nonetheless used in the literature, and so should be clarified and understood. Active euthanasia involves taking deliberate steps to end a patient's life. As an example, an administration of a lethal compound that might induce a cardiac arrest, a practice that is illegal in most jurisdictions. Passive euthanasia occur when treatments necessary for the continuance of life are withheld. In some cases, such as the administration of increasingly necessary, but toxic doses of painkillers, there is a debate whether or not to regard the practice as active or passive.[2]

According to the historian N. D. A. Kemp, the origin of the contemporary debate on euthanasia started in 1870.[27] Euthanasia is known to have been debated and practiced long before that date. Euthanasia was practiced in Ancient Greece and Rome: for example, hemlock was employed as a means of hastening death on the island of Kea, a technique also employed in Marseilles. Euthanasia, in the sense of the deliberate hastening of a person's death, was supported by Socrates, Plato and Seneca the Elder in the ancient world, although Hippocrates appears to have spoken against the practice, writing "I will not prescribe a deadly drug to please someone, nor give advice that may cause his death" (noting there is some debate in the literature about whether or not this was intended to encompass euthanasia).[28][29][30]

The term "euthanasia" in the earlier sense of supporting someone as they died was used for the first time by Francis Bacon (15611626). In his work, Euthanasia medica, he chose this ancient Greek word and, in doing so, distinguished between euthanasia interior, the preparation of the soul for death, and euthanasia exterior, which was intended to make the end of life easier and painless, in exceptional circumstances by shortening life. That the ancient meaning of an easy death came to the fore again in the early modern period can be seen from its definition in the 18th century Zedlers Universallexikon:

The concept of euthanasia in the sense of alleviating the process of death goes back to the medical historian, Karl Friedrich Heinrich Marx, who drew on Bacon's philosophical ideas. According to Marx, a doctor had a moral duty to ease the suffering of death through encouragement, support and mitigation using medication. Such an "alleviation of death" reflected the contemporary Zeitgeist, but was brought into the medical canon of responsibility for the first time by Marx. Marx also stressed the distinction between the theological care of the soul of sick people from the physical care and medical treatment by doctors.[32][33]

Euthanasia in its modern sense has always been strongly opposed in the Judeo-Christian tradition. Thomas Aquinas opposed both and argued that the practice of euthanasia contradicted our natural human instincts of survival,[34] as did Francois Ranchin (15651641), a French physician and professor of medicine, and Michael Boudewijns (16011681), a physician and teacher.[29]:208[35] Other voices argued for euthanasia, such as John Donne in 1624,[36] and euthanasia continued to be practised. In 1678, the publication of Caspar Questel's De pulvinari morientibus non subtrahend, ("On the pillow of which the dying should not be deprived"), initiated debate on the topic. Questel described various customs which were employed at the time to hasten the death of the dying, (including the sudden removal of a pillow, which was believed to accelerate death), and argued against their use, as doing so was "against the laws of God and Nature".[29]:209211 This view was shared by many who followed, including Philipp Jakob Spener, Veit Riedlin and Johann Georg Krnitz.[29]:211 Despite opposition, euthanasia continued to be practised, involving techniques such as bleeding, suffocation, and removing people from their beds to be placed on the cold ground.[29]:211214

Suicide and euthanasia became more accepted during the Age of Enlightenment.[35]Thomas More wrote of euthanasia in Utopia, although it is not clear if More was intending to endorse the practice.[29]:208209 Other cultures have taken different approaches: for example, in Japan suicide has not traditionally been viewed as a sin, as it is used in cases of honor, and accordingly, the perceptions of euthanasia are different from those in other parts of the world.[37]

In the mid-1800s, the use of morphine to treat "the pains of death" emerged, with John Warren recommending its use in 1848. A similar use of chloroform was revealed by Joseph Bullar in 1866. However, in neither case was it recommended that the use should be to hasten death. In 1870 Samuel Williams, a schoolteacher, initiated the contemporary euthanasia debate through a speech given at the Birmingham Speculative Club in England, which was subsequently published in a one-off publication entitled Essays of the Birmingham Speculative Club, the collected works of a number of members of an amateur philosophical society.[38]:794 Williams' proposal was to use chloroform to deliberately hasten the death of terminally ill patients:

That in all cases of hopeless and painful illness, it should be the recognized duty of the medical attendant, whenever so desired by the patient, to administer choloroform or such other anaesthetic as may by-and-bye supersede chloroform so as to destroy consciousness at once, and put the sufferer to a quick and painless death; all needful precautions being adopted to prevent any possible abuse of such duty; and means being taken to establish, beyond the possibility of doubt or question, that the remedy was applied at the express wish of the patient.

The essay was favourably reviewed in The Saturday Review, but an editorial against the essay appeared in The Spectator.[27] From there it proved to be influential, and other writers came out in support of such views: Lionel Tollemache wrote in favour of euthanasia, as did Annie Besant, the essayist and reformer who later became involved with the National Secular Society, considering it a duty to society to "die voluntarily and painlessly" when one reaches the point of becoming a 'burden'.[27][39]Popular Science analyzed the issue in May 1873, assessing both sides of the argument.[40] Kemp notes that at the time, medical doctors did not participate in the discussion; it was "essentially a philosophical enterprise... tied inextricably to a number of objections to the Christian doctrine of the sanctity of human life".[27]

The rise of the euthanasia movement in the United States coincided with the so-called Gilded Age, a time of social and technological change that encompassed an "individualistic conservatism that praised laissez-faire economics, scientific method, and rationalism", along with major depressions, industrialisation and conflict between corporations and labour unions.[38]:794 It was also the period in which the modern hospital system was developed, which has been seen as a factor in the emergence of the euthanasia debate.[41]

Robert Ingersoll argued for euthanasia, stating in 1894 that where someone is suffering from a terminal illness, such as terminal cancer, they should have a right to end their pain through suicide. Felix Adler offered a similar approach, although, unlike Ingersoll, Adler did not reject religion. In fact, he argued from an Ethical Culture framework. In 1891, Alder argued that those suffering from overwhelming pain should have the right to commit suicide, and, furthermore, that it should be permissible for a doctor to assist thus making Adler the first "prominent American" to argue for suicide in cases where people were suffering from chronic illness.[42] Both Ingersoll and Adler argued for voluntary euthanasia of adults suffering from terminal ailments.[42] Dowbiggin argues that by breaking down prior moral objections to euthanasia and suicide, Ingersoll and Adler enabled others to stretch the definition of euthanasia.[43]

The first attempt to legalise euthanasia took place in the United States, when Henry Hunt introduced legislation into the General Assembly of Ohio in 1906.[44]:614 Hunt did so at the behest of Anna Hall, a wealthy heiress who was a major figure in the euthanasia movement during the early 20th century in the United States. Hall had watched her mother die after an extended battle with liver cancer, and had dedicated herself to ensuring that others would not have to endure the same suffering. Towards this end she engaged in an extensive letter writing campaign, recruited Lurana Sheldon and Maud Ballington Booth, and organised a debate on euthanasia at the annual meeting of the American Humane Association in 1905 described by Jacob Appel as the first significant public debate on the topic in the 20th century.[44]:614616

Hunt's bill called for the administration of an anesthetic to bring about a patient's death, so long as the person is of lawful age and sound mind, and was suffering from a fatal injury, an irrevocable illness, or great physical pain. It also required that the case be heard by a physician, required informed consent in front of three witnesses, and required the attendance of three physicians who had to agree that the patient's recovery was impossible. A motion to reject the bill outright was voted down, but the bill failed to pass, 79 to 23.[38]:796[44]:618619

Along with the Ohio euthanasia proposal, in 1906 Assemblyman Ross Gregory introduced a proposal to permit euthanasia to the Iowa legislature. However, the Iowa legislation was broader in scope than that offered in Ohio. It allowed for the death of any person of at least ten years of age who suffered from an ailment that would prove fatal and cause extreme pain, should they be of sound mind and express a desire to artificially hasten their death. In addition, it allowed for infants to be euthanised if they were sufficiently deformed, and permitted guardians to request euthanasia on behalf of their wards. The proposed legislation also imposed penalties on physicians who refused to perform euthanasia when requested: a 612 month prison term and a fine of between $200 and $1000. The proposal proved to be controversial.[44]:619621 It engendered considerable debate and failed to pass, having been withdrawn from consideration after being passed to the Committee on Public Health.[44]:623

After 1906 the euthanasia debate reduced in intensity, resurfacing periodically, but not returning to the same level of debate until the 1930s in the United Kingdom.[38]:796

The Voluntary Euthanasia Legalisation Society was founded in 1935 by Charles Killick Millard (now called Dignity in Dying). The movement campaigned for the legalisation of euthanasia in Great Britain.

In January 1936, King George V was given a fatal dose of morphine and cocaine in order to hasten his death. At the time he was suffering from cardio-respiratory failure, and the decision to end his life was made by his physician, Lord Dawson.[45] Although this event was kept a secret for over 50 years, the death of George V coincided with proposed legislation in the House of Lords to legalise euthanasia. The legislation came through the British Volunteer Euthanasia Legalisation Society.[46]

Euthanasia opponent Ian Dowbiggin argues that the early membership of the Euthanasia Society of America (ESA) reflected how many perceived euthanasia at the time, often seeing it as a eugenics matter rather than an issue concerning individual rights.[42] Dowbiggin argues that not every eugenist joined the ESA "solely for eugenic reasons", but he postulates that there were clear ideological connections between the eugenics and euthanasia movements.[42]

A 24 July 1939 killing of a severely disabled infant in Nazi Germany was described in a BBC "Genocide Under the Nazis Timeline" as the first "state-sponsored euthanasia".[47] Parties that consented to the killing included Hitler's office, the parents, and the Reich Committee for the Scientific Registration of Serious and Congenitally Based Illnesses.[47]The Telegraph noted that the killing of the disabled infantwhose name was Gerhard Kretschmar, born blind, with missing limbs, subject to convulsions, and reportedly "an idiot" provided "the rationale for a secret Nazi decree that led to 'mercy killings' of almost 300,000 mentally and physically handicapped people".[48] While Kretchmar's killing received parental consent, most of the 5,000 to 8,000 children killed afterwards were forcibly taken from their parents.[47][48]

The "euthanasia campaign" of mass murder gathered momentum on 14 January 1940 when the "handicapped" were killed with gas vans and killing centres, eventually leading to the deaths of 70,000 adult Germans.[49] Professor Robert Jay Lifton, author of The Nazi Doctors and a leading authority on the T4 program, contrasts this program with what he considers to be a genuine euthanasia. He explains that the Nazi version of "euthanasia" was based on the work of Adolf Jost, who published The Right to Death (Das Recht auf den Tod) in 1895. Lifton writes: "Jost argued that control over the death of the individual must ultimately belong to the social organism, the state. This concept is in direct opposition to the Anglo-American concept of euthanasia, which emphasizes the individual's 'right to die' or 'right to death' or 'right to his or her own death,' as the ultimate human claim. In contrast, Jost was pointing to the state's right to kill.... Ultimately the argument was biological: 'The rights to death [are] the key to the fitness of life.' The state must own deathmust killin order to keep the social organism alive and healthy."[50]

In modern terms, the use of "euthanasia" in the context of Action T4 is seen to be a euphemism to disguise a program of genocide, in which people were killed on the grounds of "disabilities, religious beliefs, and discordant individual values".[51] Compared to the discussions of euthanasia that emerged post-war, the Nazi program may have been worded in terms that appear similar to the modern use of "euthanasia", but there was no "mercy" and the patients were not necessarily terminally ill.[51] Despite these differences, historian and euthanasia opponent Ian Dowbiggin writes that "the origins of Nazi euthanasia, like those of the American euthanasia movement, predate the Third Reich and were intertwined with the history of eugenics and Social Darwinism, and with efforts to discredit traditional morality and ethics."[42]:65

On January 6, 1949, the Euthanasia Society of America presented to the New York State Legislature a petition to legalize euthanasia, signed by 379 leading Protestant and Jewish ministers, the largest group of religious leaders ever to have taken this stance. A similar petition had been sent to the New York State Legislature in 1947, signed by approximately 1,000 New York physicians. Catholic religious leaders criticized the petition, saying that such a bill would "legalize a suicide-murder pact" and a "rationalization of the fifth commandment of God, 'Though Shalt Not Kill.'"[52] The Right Reverend Robert E. McCormick stated that

"The ultimate object of the Euthanasia Society is based on the Totalitarian principle that the state is supreme and that the individual does not have the right to live if his continuance in life is a burden or hindrance to the state. The Nazis followed this principle and compulsory Euthanasia was practiced as a part of their program during the recent war. We American citizens of New York State must ask ourselves this question: 'Are we going to finish Hitler's job?'"[52]

The petition brought tensions between the American Euthanasia Society and the Catholic Church to a head that contributed to a climate of anti-Catholic sentiment generally regarding issues such as birth control, eugenics, and population control.[42]

The petition did not lead to a law.

Historically, the euthanasia debate has tended to focus on a number of key concerns. According to euthanasia opponent Ezekiel Emanuel, proponents of euthanasia have presented four main arguments: a) that people have a right to self-determination, and thus should be allowed to choose their own fate; b) assisting a subject to die might be a better choice than requiring that they continue to suffer; c) the distinction between passive euthanasia, which is often permitted, and active euthanasia, which is not substantive (or that the underlying principlethe doctrine of double effectis unreasonable or unsound); and d) permitting euthanasia will not necessarily lead to unacceptable consequences. Pro-euthanasia activists often point to countries like the Netherlands and Belgium, and states like Oregon, where euthanasia has been legalized, to argue that it is mostly unproblematic.

Similarly, Emanuel argues that there are four major arguments presented by opponents of euthanasia: a) not all deaths are painful; b) alternatives, such as cessation of active treatment, combined with the use of effective pain relief, are available; c) the distinction between active and passive euthanasia is morally significant; and d) legalising euthanasia will place society on a slippery slope,[53] which will lead to unacceptable consequences.[38]:7978 In fact, in Oregon, in 2013, pain wasn't one of the top five reasons people sought euthanasia. Top reasons were a loss of dignity, and a fear of burdening others.[54]

In the United States in 2013, 47% nationwide supported doctor-assisted suicide. This included 32% of Latinos, 29% of African-Americans, and almost nobody with disabilities.[54]

West's Encyclopedia of American Law states that "a 'mercy killing' or euthanasia is generally considered to be a criminal homicide"[55] and is normally used as a synonym of homicide committed at a request made by the patient.[56]

The judicial sense of the term "homicide" includes any intervention undertaken with the express intention of ending a life, even to relieve intractable suffering.[56][57][58] Not all homicide is unlawful.[59] Two designations of homicide that carry no criminal punishment are justifiable and excusable homicide.[59] In most countries this is not the status of euthanasia. The term "euthanasia" is usually confined to the active variety; the University of Washington website states that "euthanasia generally means that the physician would act directly, for instance by giving a lethal injection, to end the patient's life".[60]Physician-assisted suicide is thus not classified as euthanasia by the US State of Oregon, where it is legal under the Oregon Death with Dignity Act, and despite its name, it is not legally classified as suicide either.[61] Unlike physician-assisted suicide, withholding or withdrawing life-sustaining treatments with patient consent (voluntary) is almost unanimously considered, at least in the United States, to be legal.[62] The use of pain medication in order to relieve suffering, even if it hastens death, has been held as legal in several court decisions.[60]

Some governments around the world have legalized voluntary euthanasia but most commonly it is still considered to be criminal homicide. In the Netherlands and Belgium, where euthanasia has been legalized, it still remains homicide although it is not prosecuted and not punishable if the perpetrator (the doctor) meets certain legal conditions.[63][64][65][66]

A survey in the United States of more than 10,000 physicians came to the result that approximately 16% of physicians would ever consider halting life-sustaining therapy because the family demands it, even if they believed that it was premature. Approximately 55% would not, and for the remaining 29%, it would depend on circumstances.[67]

This study also stated that approximately 46% of physicians agree that physician-assisted suicide should be allowed in some cases; 41% do not, and the remaining 14% think it depends.[67]

In the United Kingdom, the pro-assisted dying group Dignity in Dying cite conflicting research on attitudes by doctors to assisted dying: with a 2009 Palliative Medicine-published survey showing 64% support (to 34% oppose) for assisted dying in cases where a patient has an incurable and painful disease, while 49% of doctors in a study published in BMC Medical Ethics oppose changing the law on assisted dying to 39% in favour.[68]

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Libertarian Party | Libertarian Party

Posted: at 8:12 am

The Libertarian Party (LP) is your representative in American politics.We are the only political organization which respects you as a unique and responsible individual.

The Platform is our official statement on issues. It is edited and adopted every two years.

As Libertarians, we seek a world of liberty a world in which all individuals are sovereign over their own lives and no one is forced to sacrifice his or her values.

We believe that respect for individual rights is the essential precondition for a free and prosperous world, that force and fraud must be banished from human relationships, and that only through freedom can peace and prosperity be realized.

What do Libertarians have in common with liberals? What do Libertarians have in common with conservatives? Findanswers to these and other frequently-asked-questions here.

Connect with your state affiliate and see what is happening locally.

The Libertarian Party (LP)is governed by the Libertarian National Committee (LNC). Learn more aboutwho currently serves on the committee.

LNC Staff work at the partyheadquarters in Alexandria, VA, and remotely.Learn more about these Libertarians working for you.

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Trance Sample Packs, Loops & Construction Kits | Producer Loops

Posted: at 8:04 am

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Evolution | Pokmon Wiki | Fandom powered by Wikia

Posted: at 7:59 am

Evolution is the first evolutionin the Pokmon franchisewhen one Pokmon, upon reaching a certain level, using a certain stone, learning a certain move, orbeing traded, evolves into a different kind ofPokmon. In Pokmon Gold, Silver, Crystal, HeartGold and SoulSilver games, it is stated that Professor Elm is an expert on evolution, and discovered that Pikachu evolves from Pichu.

In the anime, during evolution, a Pokmon will become surrounded by a light and slowly change shape. In the Original, Advanced, and Diamond & Pearl series, the Pokmon is surrounded by a white light, while in the Best Wishes and XY series, the Pokmon is surrounded by a golden or blue light.

To some Pokmon, evolution means growing up, while to others, it just refers becoming another species or getting upgraded. However, many of them retain memories during their pre-evolution form.

Pokmon gain experience after battling wild Pokmon and Pokmon Trainers. The more experience a Pokmon gains, the more it levels up. When a Pokmon reaches a particular level, it will evolve into its next form (if it has one). This is very helpful to most Trainers who want their Pokmon to become stronger.

There are ways to share experience, such as allow a Pokmon you wish it to evolve to hold Exp. Share. It is a hold item that allows the user to earn experience even if it did not participate in the battle. This is a convenient tool if you want to level up a new or low-level Pokmon.

You can prevent evolution by simply press the 'B' button on the Game when the Pokmon is attempting to evolve. This is useful as some Pokmon will learn moves that cannot be learnt in a later form or if you want a Pokmon to learn a move earlier than usual. For example, Gabite. If you let Gible evolve into Gabite at level 24 it will learn Dragon Rush at level 49, but if you keep Gible it will learn Dragon Rush at level 37. Sometimes it doesn't matter if you let it evolve or not. The Pokmon can hold an Everstone, which keeps them from evolving, so that you don't have to keep cancelling the evolution every time the Pokmon levels up. However, if your Pokmon has evolved, it might not evolve again (Raticate, Linoone, etc.) Although some Pokmon can evolve more than once (Poliwhirl, Cascoon, etc.), some basic Pokmon just can't evolve, due to undiscovered forms, or if they are really rare (Chatot, Groudon, etc.) There are also Pokmon that can evolve into different things like love, choice, etc. For example, Eevee, Poliwhirl, Wurmple, or Kirlia.

Some Pokmon will not evolve unless you use a special stone called an Evolution Stone. These special Items are linked to the Pokmon's type. Here are a list of Pokmon that can evolve by giving them the stones.

Some items are needed for a Pokmon to evolve. If a Pokmon hold the item allowing it to evolve, let it level up once and it will then evolve into the second form.

A small group of Pokmon refuses to evolve, no matter if you are at the appropriate level to trigger the evolve process, unless you trade them with a friend. Some Pokmon need to have a held item to evolve when trading with a friend. Another group require specific Pokmon to be trade in order to evolve.

Small groups of Pokmon requires a gender to evolve into the next stage.

Certain Pokmon, especially baby Pokmon, requires friendship with its trainer and if they are fond enough, they are willing to evolve. Some Pokmon only evolves in a certain time of the day with friendship.

Special Pokmon evolve at a certain area of location.

Certain Pokmon need to know a move to evolve. This method was introduced in Generation IV, starting with Diamond/Pearl/Platinum.

The current time of day will sometimes affect evolution. This method was introduced in Generation VI, starting with X/Y/OR/AS.

Some Pokmon have certain type of unique way of evolve.

Certain Pokmon will be able to evolve into a Mega form, the final form for one-evolution families and second/true final form for two-evolution families with the use of a Mega Stone, a held object. However this evolution will devolve back into their previous form at the end of the battle.

There's a special evolution that Ash's Greninja can do due to his strong bond with Ash called Ash-Greninja, that was later described as Bond Phenomenon.

Primal Reversion is a similar state to Mega Evolution, but the Pokmon devolve to a previous state in the past.

It is a possible game mechanic in Pokmon Omega Ruby & Alpha Sapphire, most likely because this mechanic was founded during development of Pokmon Omega Ruby & Alpha Sapphire.

Devolution is a form of reverse evolution when a Pokemon reverts to a previous state. Devolution does not exist in the games but is common in the Manga and TCG. Devolution is achieved mainly unnaturally - through experimentation, or Devolution Spray. Though certain Pokemon, such as Isamu's Clefairy and Pikachu are capable of devolving themselves. The TCG also has it that Eeveelutions can revert into Eevee and that Mew has twospecial attacks named the Devolution Beam and Devo Crush - both of which which devolves the Pokemon hit by the attack. Golurk and Jirachi also possess special attacks which allow them to devolve an opposing Pokemon.

In the Anime Episode, Electric Shock Showdown, Misty points out that once Pikachu evolves with the use of the Thunder Stone, Pikachu won't revert back.

In An Epic Defense Force, Luke's Golett seemingly evolves to Golurk in a Movie then Devolves back to Golett, repairing the Golurk Statue, as it turns out to be fictitious.

Another instance of the non-existence of Devolution, is when Bonnie requested Ash's Frogadier to devolve back to Froakie, Clemont said that it would be impossible.

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Evolution – RationalWiki

Posted: at 7:59 am

There is grandeur in this view of life, with its several powers, having been originally breathed into a few forms or into one; and that, whilst this planet has gone cycling on according to the fixed law of gravity, from so simple a beginning endless forms most beautiful and most wonderful have been, and are being, evolved.

Evolution refers to change in a biological population's inherited traits from generation to generation. Some believe that: all species on Earth originated by the mechanism of evolution, through descent from common ancestors. Evolution occurs as changes accumulate over generations. Charles Darwin recognized evolution by natural selection, also called "descent with modification", as the fundamental process underlying all of life, whether viewed at a large scale above the level of species (macroevolution), in terms of formation of new species, changes within lineages, and extinction, or at a small scale within a species (microevolution), in terms of change in gene frequency. (Keep in mind that this entire page is based on the idea that something came from nothing. If any of this were true, we would be continually shifting in shape and "breed". Humans were created separately when life began. (Genesis 1.)) In a nutshell, evolution by natural selection can be simplified to the following principles:

In modern genetic terminology, variability of traits in a population is the expression (phenotype) of heritable traits (genes), which at least on Earth are stored in DNA (or sometimes RNA or proteins). Variability of traits ultimately originates from mutation, and new combinations of genes are continually produced via recombination as part of sexual reproduction. The result of natural selection is adaptation, like a "hand in glove" fit between organism and environment. Evolution, defined in population genetics as change in gene frequency in a population, can be influenced by other processes besides natural selection, including genetic drift (random changes, especially in small populations) and gene flow (wherein new genes come into a population from other populations). In a sense, mutation is a creative process of expansion in which new possibilities come into existence (most of which don't work so well), and this is balanced by natural selection, another creative process of contraction that reduces the possibilities to those that work best in a particular environment.

It sure felt good when Earth was flat, Earth was the center of the universe, Earth was only about 6,000 years old, life on Earth originated as the handiwork of a supernatural creator, and when species were fixed and didn't evolve. And it felt really good when humans were special, created separately from other life on Earth, not descended from a common ancestor. So what if understanding evolution revolutionized our entire worldview. Reality is overrated.

The word evolution (from the Latin e, meaning "from, out of," and volvo, "to roll," thus "to unroll [like a scroll]") was initially used in 1662, and was variously used, including with respect to physical movement, describing tactical wheeling maneuvers for realignment of troops or ships. In medicine, mathematics, and general writing early use of the term referred to growth and development within individuals.[2][3]; its first use in relation to biological change over generations came in 1762, when Charles Bonnet used it for his now outdated concept of "pre-formation", in which females carried a miniature form (homunculus) of all future generations. The term gradually gained more general meaning of progressive change. In 1832 Scottish geologist Charles Lyell referred to gradual change over long periods of time. Charles Darwin only used the word in print once, in the closing paragraph of The Origin of Species (1859), and rather favored the phrases "transmutation by means of natural selection" and "descent with modification". In the subsequent modern synthesis of evolution, Julian Huxley and others adopted the term, which thereby became the accepted technical term used by scientists.[4][5]Although in contemporary usage the term "evolution" most commonly refers to biological evolution, usage has evolved, and the word also refers more generally to "accumulation of change", including in many disciplines besides biology.

The idea that life has evolved over time is not a recent one, and Charles Darwin did not, in fact, come up with the idea of evolution in general. For example, ancient Greek philosophers, like Aristotle, had ideas about biological development.[6] Later, in Medieval times, Augustine used evolution as a basis for the philosophy of history.[6]

The first significant step in the theory of evolution was made by Carl Linnaeus.[7] His leading contribution to science was his creation of the binomial system of nomenclature in lay terms, the two-part name given to species, such as Homo sapiens for humans. He, like other biologists of his time, believed in the fixity of the species, and in the scala naturae, or the scale of life. His ideas were consistent with the Judeo-Christian teachings of his time.

Erasmus Darwin, the grandfather of Charles Darwin, was the first scientist to whom credit can be given for something starting to approach modern concepts of evolution, as noted in his contributions to botany and zoology. His writings contained many comments (mostly in footnotes and side writings) that suggested his beliefs in common descent. He concluded that vestigial organs (such as the appendix in humans) are leftovers from previous generations. The elder Darwin, however, offered no mechanism by which he believed evolution could occur.

Georges Cuvier proposed a mechanism by which the fossil record could develop over time without evolution - which by now had come into usage as a term.[8] His hypothesis, catastrophism, was that a series of disasters destroy all life within a limited area, and that living organisms move in to this newly opened area. This idea prefigures in some respects the 1970s hypothesis of 'punctuated equilibrium'.

Lamarck was the first scientist to whom credit can be given for a theory of evolution.[9] His idea centered on use and disuse, the concept being that the more an organism used a particular part of its body, the more developed that organ became within a species. It is sound only for individuals (e.g. a weightlifter will develop larger muscles over time, but will not pass this trait on to any children.) Nevertheless, modern research into epigenetics suggests that parents can induce some traits into their offspring by non-genetic inheritance, and that Lamarck was therefore not completely wrong.

By the first half of the 19th century, scientists had gathered a great deal of information on species, and had inferred that life on Earth had existed for a very long time, and that some species had become extinct.[10] Natural selection was the first theory to provide a mechanism to explain those observations. Prior to the theory of natural selection, the concept that species could change over time had been proposed, but without a satisfactory explanation.[Who?]Alfred Russel Wallace and Charles Darwin came to the conclusion, independently, that competition for resources and the struggle for survival helped determine which changes became permanent and which traits were discarded.

The theory of evolution by natural selection, as we know it today, was published in a joint paper by Wallace and Darwin on 20 August, 1858, based on Wallace's observations in the Malay Archipelago and Darwin's observations over many years including those made during his voyage on HMS Beagle. Charles Lyell's Principles of Geology, which suggested slow changes over very long periods of time, also contributed to the nascent theory.[11] Darwin drew heavily on his knowledge of human experience in breeding domestic animals (artificial selection), particularly the varieties produced by pigeon breeders (Darwin was one himself), for his understanding of how variations could develop within a population over time. Darwin set out his theory (at the time, a hypothesis) of natural selection in his books On the Origin of Species and The Descent of Man.[12]

For more information, see Non-Darwinian evolution.

Although natural selection was the first mechanism proposed in evolutionary theory (and remains the most common), other forms of selection play a part as well. The most notable of these is sexual selection, which occurs due to some heritable preference for a trait in breeding partners. Derivation of traits through this mechanism is driven by (usually) the female's choice in mating partner rather than direct impact on fitness. Sexual selection often leads to the rise of features which would likely not occur under natural selection, such as the tail of a peacock or the long necks of giraffes.[13]

It should be noted that sexual selection can be divided into two forms, distinguishable by who actually "makes" mating decisions. The first of these is intersexual selection, and in this form of selection the limiting sex (which is usually female) will choose a partner. The other form is intrasexual selection, or mate competition. In this form of selection, one sex (usually males) competes for "mating rights" to members of the other sex.

In addition to selection, other mechanisms have been proposed, most notably genetic drift. More controversial is the importance of symbiosis (which has been recognized in the case of the origins of eukaryotes). Universally rejected is Lamarckism or directed (rather than random) variations.

The eclipse of Darwinism is a phrase to describe the state of affairs prior to the modern synthesis when evolution was widely accepted in scientific circles but relatively few biologists believed that natural selection was its primary mechanism. Instead non-Darwinian mechanisms of evolution such as neo-Lamarckism, saltationism, or orthogenesis were advocated. These mechanisms were included in most textbooks until the 1930's but were rejected by the neo-Darwinian synthesis theorists in the 1940's as evidence had proven the role of natural selection in evolution.[14]

The modern evolutionary synthesis is a union of ideas from several biological specialties, which attempts to explain how evolution proceeds. It has been accepted by many scientists. It is also referred to as the new synthesis, the evolutionary synthesis, the neo-Darwinian synthesis, or the synthetic theory of evolution. The synthesis was produced between 1936 and 1947 due to the reconciliation of Mendelian genetics with natural selection into a gradual framework of evolution. The synthesis of Darwinian natural selection (1859) and Mendelian inheritance (1865) is the cornerstone of neo-Darwinism.[15]

Julian Huxley (1887 1975) invented the term, when he produced his book, Evolution: The Modern Synthesis (1942). Other major figures in the modern synthesis included R. A. Fisher (1890 - 1962), Theodosius Dobzhansky (1900 - 1975), Ernst Mayr (1904 - 2005), George Gaylord Simpson (1902 1984), and G. Ledyard Stebbins (1906 - 2000).

Over the past decade, new conceptions of evolutionary theory have emerged going under the umbrella term of the "Extended Synthesis," which is intended to modify the existing Modern Synthesis. This proposed extended synthesis incorporates new possibilities for integration and expansion in evolutionary theory, such as Evo-devo, Epigenetic Inheritance and Niche Construction. Its proponents include Massimo Pigliucci, Gerd Mller, and Eva Jablonka.[16] In 2008 sixteen scientists met at the Konrad Lorenz Institute in Altenberg, Austria, to propose an extended synthesis.[17]

Evolutionary theory has at its core three main tenets, observations of patterns within nature. These three patterns were observed by both Darwin and Wallace, and they eventually gave rise to the modern theory of evolution by natural selection.[18]

Darwin and Wallace both noted that populations display natural variability in form, physiology, and behaviour (phenotypic variability). For example, within a population, some members may be very large, some may be very small, and most may be somewhere in the middle. This natural variability is the fundamental source upon which natural selection acts.

Having observed that natural variability exists, early evolutionary biologists also noted that some of these variants endowed their possessor with some competitive edge over other members of the species, conferring greater survival or reproduction. Although at first the implications of this fact were unclear, the writings of Thomas Malthus spurred Darwin and Wallace to recognize that individuals that have traits that enhance their ability to survive and reproduce pass on these traits to subsequent generations. Differential fitness, also known as differential reproductive success, in essence, is the process by which traits that enhance survival and reproduction gain greater representation in subsequent generations.

Only if variation is heritable, will it confer an advantage into future generations. Although early evolutionary scientists did not have the benefit of modern molecular tools, they surmised that the source of variation must in part have a heritable basis, in contrast with variation expressed solely in response to different environmental conditions. In fact, one of the first predictions made by evolutionary theory was the existence of a heritable factor, now known to be DNA!

Thus the combination of phenotypic variability, differential fitness, and heritability of fitness define evolution by natural selection. Darwin and Wallace independently came to the conclusion that those organisms best suited to their environment would survive to produce more offspring. Therefore, the heritable factor responsible would increase in frequency within the population.[19]

Evolutionary biology seeks to explain the following three broad patterns observable in all life.

Diversity is fundamental to life at all levels of organization: ecosystems, communities, species, populations, individuals, organs, and molecules.

According to the Genetic Variation Program arm of the National Human Genome Research Institute, about 99.5% of human DNA is the same from person to person. The other 0.5% accounts for a number of simple and complex traits we possess.[20] There is tremendous genetic diversity within almost all species, including humans. No two individuals have an identical DNA sequence, with the exception of identical twins or clones. This genetic variation contributes to phenotypic variation - that is, diversity in the outward appearance and behavior of individuals of the same species.

Populations must adapt to their environment to survive.

Living organisms have morphological, biochemical, and behavioral features that make them well adapted for life in the environments in which they are usually found. For example, consider the hollow bones and feathers of birds that enable them to fly, or the cryptic coloration that allows many organisms to hide from their predators or prey. These features may give the superficial appearance that organisms were designed by a creator (or engineer) to live in a particular environment. Evolutionary biology has demonstrated that adaptations arise through selection acting on a population through genetic variation.

Species evolved along different paths from a common ancestor.

All living species differ from one another. In some cases, these differences are subtle, while in other cases the differences are dramatic. Carl Linnaeus (1707-1778) proposed a classification that is still used today with slight changes. In the modern scheme, related species are grouped into genera, related genera into families, and so on. This hierarchical pattern of relationship produces a tree-like pattern, which implies a process of splitting and divergence from a common ancestor. While Linnaeus classified species using similar physical characteristics, modern evolutionary biologists also base classification on DNA analysis, which can distinguish between superficial resemblances between species and those which are due to common ancestry.

Biological evolution results from changes over time in the genetic constitution of species. The accumulation of genetic variations often, but not always, produces noticeable changes in the appearance or behavior of organisms. Evolution requires both the production of variation and the spread of some variants that replace others.[21]

Genetic variation arises through two processes, mutation and recombination. Mutation occurs when DNA is imperfectly copied during replication, or by changes in genetic material caused by such mutagens as radiation, leading to a difference between a parent's gene and that of its offspring. Some mutations affect only one bit in the DNA; others produce rearrangements of, or changes in, large blocks of DNA.

Recombination occurs when genes from two parents are shuffled to produce an offspring, as happens in every instance of sexual reproduction. Usually the two parents belong to the same species, but sometimes (especially in bacteria) genes move between more distantly related organisms.

The fate of any particular genetic variant depends on two processes, drift and selection. Drift refers to random fluctuations in gene frequency, and its effects are usually seen at the level of DNA. Ten flips of a coin do not always (or even usually) produce exactly five heads and five tails; drift refers to the same statistical issue applied to the transmission of genetic variants across generations. Genetic drift is inverse to population size; that is, genetic drift has a greater effect on small populations than larger ones. For example, if a small part of a population becomes geographically isolated its members will develop new traits faster.

The principle of natural selection was discovered by Charles Darwin (1809-1882), and it is the process by which organisms become adapted to their environments. Selection occurs when some individual organisms have genes that encode physical or behavioral features that allow them to better harvest resources, avoid predators, reproduce successfully, and so forth, relative to other individuals that do not carry those genes. The individuals that have more useful (adaptive) features will tend to leave more offspring than other individuals, so the responsible genes will become more common over time, leading the population as a whole to become better adapted.

Through a variety of mechanisms, gene duplication can occur which gives rise to two identical genes in the genome. Since only one of these genes is necessary, the other gene can undergo mutations without having an adverse effect on the original function of the gene. These duplicated genes called paralogs can give rise to protein families with similar yet distinctly different functions. For example, the olfactory protein family consists of around 900 different smell receptors that all arose via gene duplication followed by unimpeded mutation.

The process that many people find most confusing about evolution is speciation, which is not a separate mechanism at all, but rather a consequence of the preceding mechanisms played out in time and space. Speciation occurs when a population changes sufficiently over time that it becomes convenient to refer to the early and late forms by different names. Speciation also occurs when one population splits into two distinct forms that can no longer interbreed. Reproductive isolation does not generally happen in one generation; it may require many thousands of generations when, for example, one part of a population becomes geographically separated from the rest and adapts to a new environment. Given time, it is inevitable that two populations that live apart will diverge by mutation, drift, and selection until eventually their genes are no longer compatible for successful reproduction.

Working alongside with natural selection (death and survival pressure), spatial evolution is caused by individuals with random variation that are selected nonrandomly by how fast they travel away from home populations. The faster the individuals, the faster the individual she or he mates with, leading to fast offspring. This is both behavioral and morphological. The individuals 'race' their way to become a distinct species. Examples of Spatial evolution are new. For example, Australian researchers have detailed a new mechanism of evolution that is not based on natural selection but rather on how populations of organisms, such as cane toads, move around.[22][23]

Common descent explains the many shared features (homologies) of the majority of the organisms on the planet. There is an enormous amount of evidence that suggests all living organisms derived from a common ancestor long ago. For instance, all vertebrate embryos have the same body plan and look very similar in early development. We have the genetic code, which is all but identical in every known organism, from bacteria to humans. We have the shared presence of pseudogenes in similar species. All simians, including us humans, have an inactive gene, L-gulonolactone oxidase, which was originally used to synthesize Vitamin C. Then, we have the evidence for convergence, which explains relationships for all species, from fungal slime you find in shower stalls to sequoia. The tree of life between simple anatomical similarities is strikingly similar to a tree constructed from genetic molecular similarities. Then, there are others, including cool stuff like chromosome fusion, endosymbotic theory, retroviruses, Hox genes, and deep homology, oh my.

Considering all of this, evolution has the intricacy and the reality of quantum mechanics. But you don't see unqualified people running around and decrying quantum mechanics, do you? Well actually you do, but opposition to quantum mechanics is widely considered fringe kookery, while opposition to evolution is treated by many people as a reasonable position.

So yes, in other words, evolution is a theory.

Evolutionary concepts can also be applied to non-biological processes. Universe formation, evolutionary algorithms in computer science and the development of languages are three such subjects. The study of etymology is one component of analyzing how languages have evolved, and parallels biological evolution (for example) in the way the same language diverges over time into two different languages when two populations that speak the same language become geographically isolated.

Another example of non-biological evolution is the evolution of technology and innovation, which, while being (mostly) intelligently-designed,[24] is (mostly) not random. James Burke studied, authored books, and hosted television programmes on the evolution of technology through a historical context.

Models of cultural evolution, such as memetics, have been devised and applied over the years with varying degrees of success.[25]

Somewhat confusingly, the word "evolution" is also used in some sciences in a way that has no relation to the biological concept whatsoever. When an astronomer speaks of "stellar evolution", (s)he is taking about the changes that happen to a star over very long periods of time, as it progresses from gas cloud to protostar to main sequence star to post-main-sequence giant to stellar remnant. When a cosmologist speaks of "cosmic evolution", (s)he is talking about the changes in the size/shape/nature of the universe over time, sometimes on very long time scales, and sometimes at very brief time scales (such as fractions of a second after the Big Bang). Neither of these uses of the word "evolution" has anything to do with populations, heritable traits, selection criteria, descent, or any of the other hallmarks of "evolution" as the term is used in biology.

Creationists consequently confuse the biological and non-biological meanings of the word "evolution" and they claim that the Theory of Evolution includes the origin of the universe and the origin of life. The biological theory of evolution as proposed by Darwin and others has nothing to say about either the origin of the universe or the origin of life on Earth, though some biologists have extended the theory to the very beginning of life.[26]

There are a number of broad arguments creationists/anti-evolutionists make. Specific claims are examined at our common descent page. They're mostly arguments born of a lack of understanding what evolution by mutation and natural selection actually is, though rarely they're advanced by more savvy creationists as direct misrepresentations and distortions of the theory of evolution.

Often creationists ask how likely it is that all this complex life could have come about by random chance. They suggest that since individual events, such as the abiogenetic formation of proteins, emergence of RNA, organization of unicellular into multicellular organisms, etc., are purportedly so highly improbable that the entire chain events culminating in the existence of even a single complex organism could not have happened as described. Therefore, God did it. As creationism is largely a program of negative apologetics (e.g. an attempt to show a claim that is viewed as contrary to Christian faith is internally inconsistent or irrational according to the Christian perspective), arguments such as this are in essence arguments from incredulity with the proponent denying a fact (in this case the statistical probability that such and such essential event will have occurred) in order to draw the unsupported conclusion that some other cause (the Christian God) was at work.

The implied argument that a god or "designer" was at work is itself fraught with more untenable problems. Putting aside that the illusion of design is itself problematic, and assuming for the sake of argument that "design" is even identifiable in biological systems, if "random chance" is inadequate to account for some outcome, one is simply making unsupported assertions to contend that it is more probable that a designer was at work. If the causes are "designers" about which nothing is known, if they are capable of doing anything, if it is not known how or why they act, if it is not known when they acted (or will act), or if it is not known what they did (or did not, or could, or would), the causes are not enough to account for the results. If so, "design" in this sense is indistinguishable from random chance.

Nonetheless, evolution by natural selection isn't a random process. While genetic mutations may appear randomly, the natural selection of specific traits to produce a statistically significant allele (gene variation) frequency in a discrete population of organisms is highly deterministic. If a gene aids survival with respect to any particular environmental stressor, then it is selected by means of the survival and reproduction of the individuals carrying that gene and perpetuates in the population of organisms. If the trait is detrimental to survival, it will leave organisms vulnerable to a particular environmental stressor and through attrition lower the frequency of the allele(s) contributing to that trait in the subject population.

Many creationists hold erroneous beliefs about evolution such as that which is expressed by the statement "I accept microevolution, but not macroevolution." (This is the position of YEC nincompoop Kent Hovind.) Microevolution is supposed to be evolution that doesn't result in a new species, and macroevolution is supposed to be evolution that does lead to a new species. This argument is akin to someone saying that while one believes that wind can sometimes erode rock, one doesn't believe it can change the rock's shape. Micro- and macroevolution describe the same process, but with a difference in operational time. If one accepts microevolution, they must also accept macroevolution, since the former inevitably leads to the latter if given a long enough time period and the separation of breeding isolates. One cannot simply accept one and not the other. In biology, macroevolution is a broad subject of which speciation is only one part. This argument against speciation may be an attempt by creationists to reserve the power to produce a species for God alone.

Some creationists have abandoned the attempt to deny that new species can appear (and disappear) by natural means, in favor of drawing a barrier, not between species, but between baramins (also known as "kinds"), some sort of collection larger than species. To date, there has not been given any indication of just what sort of a thing a baramin is, what is the nature of the barrier between baramins, or how one might detect the barrier (or suspect its non-existence) in any particular case, other than the uninformative "baramins are those things that present a barrier to evolution."

Irreducible complexity is a fancy name for the "watchmaker" argument. In a nutshell, irreducible complexity describes an organ (or other facet of a living thing) which the ideology's supporters claim could not have evolved in small gradual steps. It is claimed to be so complex that it cannot be reduced into other parts. In fact, every example of irreducible complexity Behe and others have come up with has been shown to not be irreducibly complex (for example, the incremental stages towards the "irreducibly complex" human eye that are found in the sight organs of other living organisms).[27]

For any theory to be accepted as scientific it must be falsifiable. In other words, it must be capable of making statements which could theoretically be disproved. Evolution's opponents claim that the theory of evolution does not have this property, although this claim can be easily rejected. Theoretically, evolution could be falsified if scientists discovered an organism so complex and unique, with absolutely no explainable path as to how it could have evolved. Such an organism has not been found. Similarlyand ironicallythere are the demands made by some creationists that they be shown, say, a dog giving birth to a cat before they'll accept evolution. Such an event, if it occurred, would falsify (or at least strongly challenge) evolution, since speciation doesn't happen in a single generation and modern animals don't evolve into other modern animals.

Sometimes the phrase "evolution is only a theory" will be heard. This phrase rests on the common use of "theory" to mean what scientists call a "hypothesis," i.e., is something that is possible but not proven. Science, however, uses "theory" in a much different sense, namely as a testable model of the manner of interaction of a set of natural phenomena, capable of predicting future occurrences or observations of the same kind, and capable of being tested through experiment or observation. This sets it at a significantly higher level of reasoning than "wild and unproven guess," which is what is implied when this argument is mentioned. Also unlike "wild guesses", scientific theory is among the best explanations for phenomena, and scientists who successfully create new theories will often be famous. As Sheldon Cooper once said, "Evolution isn't an opinion, it's fact."[28] Note that creationists don't say that gravity is "only a theory." And if anyone says you can't directly observe evolution, send them to Professor Lenski.

Strictly speaking, evolution is something that happens in the world of life, and should be distinguished from a theory of evolution, which is (according to the above definition) a model of how evolution occurs. Thus evolution bears the same relationship with a theory of evolution as flight with a theory of flight, or sound with a theory of sound, or planetary motion with a theory of planetary motion. This is often expressed in the saying that "Evolution is both a theory and a fact", that is to say, the word "evolution" can refer not only to the process (the "something that happens"), but also to a fact that it is observed under such-and-such circumstances, and to a theory that is involved with the process ("how it happens", "what the consequences are of it happening").[29]

One creationist claim is that there is a lack of support for evolution among scientists. This claim has for example been articulated, "Interestingly, ever since Charles Darwin's book The Origin of Species was published in 1859, various aspects of the theory have been a matter of considerable disagreement even among top evolutionary scientists."[30] To counter this claim one need only note that scientists' disagreements are about details over the way that evolution functions - and not about the historical fact of it.

Many simulations of evolution (of digital creatures) towards some goal exist. Some of the best are documented here:

In which creatures made of nodes and muscles frantically try to run to the right. Code publicly available; run it online![31]

In which randomly generated octagons with wheels frantically try to drive to the right. Run it online![32] Code not publicly available; explanation available.[33]

Or, "Evolution IS a Blind Watchmaker". Watch a bunch of gears, ratchets, clock hands, and springs frantically try to accurately tell time, and simultaneously disprove the watchmaker analogy. Code publicly available.[34]

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Types of Complementary and Alternative Medicine | Johns …

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Many different areas make up the practice of complementary and alternative medicine (CAM). In addition, many parts of one field may overlap with the parts of another field. For example, acupuncture is also used in conventional medicine. In the U.S., CAM is used by about 38% of adults and 12% of children. Examples of CAM include:

Traditional alternative medicine. This field includes the more mainstream and accepted forms of therapy, such as acupuncture, homeopathy, and Oriental practices. These therapies have been practiced for centuries worldwide. Traditional alternative medicine may include:

Body. Touch has been used in medicine since the early days of medical care. Healing by touch is based on the idea that illness or injury in one area of the body can affect all parts of the body. If, with manual manipulation, the other parts can be brought back to optimum health, the body can fully focus on healing at the site of injury or illness. Body techniques are often combined with those of the mind. Examples of body therapies include:

Diet and herbs. Over the centuries, man has gone from a simple diet consisting of meats, fruits, vegetables, and grains, to a diet that often consists of foods rich in fats, oils, and complex carbohydrates. Nutritional excess and deficiency have become problems in today's society, both leading to certain chronic diseases. Many dietary and herbal approaches attempt to balance the body's nutritional well-being. Dietary and herbal approaches may include:

Dietary supplements

Herbal medicine

Nutrition/diet

External energy. Some people believe external energies from objects or other sources directly affect a person's health. An example of external energy therapy is:

Electromagnetic therapy

Reiki

Qigong

Mind. Even standard or conventional medicine recognizes the power of the connection between mind and body. Studies have found that people heal better if they have good emotional and mental health. Therapies using the mind may include:

Meditation

Biofeedback

Hypnosis

Senses. Some people believe the senses, touch, sight, hearing, smell, and taste, can affect overall health. Examples of therapies incorporating the senses include:

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Automation – DESHAZO

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Robotic Systems for Advanced Performance

If you want to improve the quality or productivity of an existing manual manufacturing/assembly process or lower the operating cost, DESHAZO can provide you with an engineered solution to meet your requirements. Our engineers will visit your site, observe your manufacturing processes and prepare a 3-D conceptual design of the equipment or system to meet your requirements. We employ the latest technology in design and manufacturing processes including SolidWorks, AutoCAD, Catia, and Robot Simulation software as well as CNC manufacturing equipment in our plant.

In addition, DESHAZO has the ability to analyze the financial benefits of a prospective automation project in your facility. Working with your personnel, we can assist in calculations on the projected improvement in productivity, quality and operating cost, as well as the return on investment of an automation project.

DESHAZO has the engineering and manufacturing expertise to design, build and install one work cell or a complete automation system in your facility to meet your requirements. We have the capability to handle all aspects of your automation project to provide a complete solution for your needs. We have experience in many industrial segments including steel manufacturing, foundry operations, appliance manufacturing, aerospace, automotive, construction machinery, consumer products and material handling. We have extensive experience in the following manufacturing processes:

DESHAZOs team has designed, built and installed all kinds of manual, semi-automated and fully automated assembly systems.

DESHAZO has developed solutions for virtually every type of testing and inspection situation, including mechanical, functional, electrical, and leak detection/flow measurement testing.

Whether youre working with simple gravity conveyors or complex, fully programmable sorting/inspection lines, DESHAZO can provide integrated material handling systems to suit your needs.

DESHAZO has developed robotic solutions for welding applications including precise laser welding, plastics joining, resistance welding and automated wire feed welding applications.

With DESHAZOs integrated control systems, you will be able to know, control, and react to everything that occurs in your operation. DESHAZO is proficient in the application of many controls systems including Allen Bradley, Omron, Mitsubishi, GE, and Toyopuc PLCs, as well as other custom computer programs and database design.

DESHAZO can provide you with robotic vision systems to perform quality control inspections, parts picking and other applications to lower hard tooling costs.

DESHAZO can provide you with a robotic packaging system that will determine what product goes into a particular package and then box the product.

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Automation - DESHAZO

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