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Daily Archives: November 2, 2016
Cyrenaics | Internet Encyclopedia of Philosophy
Posted: November 2, 2016 at 6:59 am
The Cyrenaics are one of the minor Socratic schools. The school was founded by Aristippus, a follower of Socrates. The Cyrenaics are notable mainly for their empiricist and skeptical epistemology and their sensualist hedonism. They believe that we can have certain knowledge of our immediate states of perceptual awareness, e.g., that I am seeing white now. However, we cannot go beyond these experiences to gain any knowledge about the objects themselves that cause these experiences or about the external world in general. Some of their arguments prefigure the positions of later Greek skeptics, and their distinction between the incorrigibility of immediate perceptual states versus the uncertainty of belief about the external world became key to the epistemological problems confronting philosophers of the 'modern' period, such as Descartes and Hume. In ethics, they advocate pleasure as the highest good. Furthermore, bodily pleasures are preferable to mental pleasures, and we should pursue whatever will bring us pleasure now, rather than deferring present pleasures for the sake of achieving better long-term consequences. In all these respects, their iconoclastic and 'crude' hedonism stands well outside the mainstream of Greek ethical thought, and their theories were often contrasted with Epicurus' more moderate hedonism.
The Cyrenaic school was founded by Aristippus (c. 435-356 B.C.), a follower of Socrates and a rough contemporary of Plato. The name 'Cyrenaic' comes from Cyrene, Aristippus' home town, a Greek colony in Northern Africa. Aristippus taught philosophy to his daughter Arete, who in turn taught philosophy to her son Aristippus. Aristippus the younger formulated many of the theories of the Cyrenaic school, so that some scholars count him as being more properly the founder of the school, with Aristippus the Elder being merely the school's figurehead. However, disentangling the exact contributions of the two to the Cyrenaic philosophy is difficult. Later Cyrenaics, notably Hegesias, Anniceris, and Theodorus, who were rough contemporaries of Epicurus, modified the Cyrenaic ethical doctrines in different directions, and the school died out shortly afterwards, around the middle of the 3rd century B.C. However, it did have some influence on later philosophers. Epicurus most likely developed some of the distinctive features of his ascetic hedonism in order to avoid what he saw as the unpalatable consequences of Cyrenaic hedonism, and many of the Cyrenaic arguments against the possibility of gaining knowledge of the external world were appropriated by later academic and Pyrrhonian skeptics.
The Cyrenaics are empiricists and skeptics. As empiricists, they believe that all that we have access to as a potential source of knowledge are our own experiences. These experiences are private to each of us. We can have incorrigible knowledge of our experiences (that is, it impossible to be mistaken about what we are currently experiencing), but not of the objects that cause us to have these experiences. This results in their skepticism---their conviction that we cannot have knowledge of the external world.
The Cyrenaics affirm that path--affections, or experiences--are the criterion of knowledge. They distinguish sharply between the experiences that one has--e.g., that I am now seeing gray--and the objects that cause one to have these experiences--e.g., the computer screen.
We can have infallible knowledge of our own experiences, since we have immediate access to them, but we do not have access to objects and qualities in the external world. As the Cyrenaics put it, "The experience which takes place in us reveals to us nothing more than itself." The Cyrenaics reinforce this point by saying that, strictly speaking, we should not say, "I am seeing something yellow," for instance, but "I am being yellowed," or "I am being moved by something yellowly," since the latter statements make it clear that we are reporting only our immediate perceptual state. (In this respect, the Cyrenaics bear a striking resemblance to some modern epistemologists, who resort to locutions like "I am being appeared to redly now" as describing accurately what is immediately given to us in experience.)
The Cyrenaics have two main arguments for why it is impossible to make inferences about the qualities of objects in the external world on the basis of our experiences:
The Cyrenaics note that the same object can cause different perceivers to experience different sensible qualities, depending on the bodily condition of the perceivers. For instance, honey will taste sweet to most people, but bitter to somebody with an illness, and the same wall that appears white to one person will look yellow to somebody with jaundice. And if a person presses his eye, he sees double.
From the fact that the wall appears white to me and yellow to you, the Cyrenaics think we should infer that we cannot know which quality the wall itself has on the basis of our experience of it, presumably because we have no criterion outside of our experiences to use to adjudicate which one (if either) of our experiences is correct. Such arguments from the relativity of perception are common in ancient Greek philosophy, and other thinkers draw different conclusions; for example, Protagoras says we should conclude that the wall is both white (for me) and yellow (for you), while Democritus thinks that we should conclude that it is neither white nor yellow.
Even if all people were to agree on the perceptual quality that some object has--for instance, that a wall appears white--the Cyrenaics still think that we could not confidently say that we are having the same experience. This is because each of us has access only to our own experiences, not to those of other people, and so the mere fact that each of us calls the wall 'white' does not show us that we are all having the same experience that I am having when I use the word 'white.'
This argument of the Cyrenaics anticipates the problem of other minds---that is, how can I know that other people have a mind like I do, since I only observe their behavior (if even that), not the mental states that might or might not cause that behavior?
The Cyrenaic position bears some striking resemblance to the relativistic epistemology of the sophist Protagoras, as depicted in Plato's dialogue Theaetetus, and to the skeptical epistemology of the Pyrrhonists. Because of this, the Cyrenaics' epistemology is sometimes wrongly assimilated that of Protagoras or the Pyrrhonists. However, the Cyrenaics' subjectivism is quite different from those positions, and explaining their differences will help bring out what is distinctive about the Cyrenaics.
The Cyrenaics and Protagoras do have similar starting-points. Protagoras also says that knowledge comes from perception. He uses basically the same arguments from relativity that the Cyrenaics use, and on their basis asserts that each of us infallibly has knowledge of how things appear to us. So, if I feel that the wind is hot, and judge that "the wind is hot," I am judging truly (for me) how the wind is. And if the wind feels not-hot to you, and you judge that "the wind is not hot," you are also judging truly (for you) how the wind is. These apparently contradictory statements can both betrue, since each of us is judging only about how things appear to us.
However, there are important differences between Protagoras' relativism and the Cyrenaics' subjectivism. The Cyrenaics would more likely want to say "that the wind appears hot to me is true" (simpliciter) rather than "'The wind is hot' is true-for-me." The Cyrenaic position retains the possibility of error whenever you go beyond the immediate content of your experience, whereas Protagoras says that however things appear to you is 'true for you.' According to the Cyrenaics, I may know infallibly that "I am being appeared to hotly now," but if I were to say that the wind itself were hot, I might be mistaken, and if I were to judge that "You are being appeared to hotly now," whereas in fact you were having a chilly experience, I would be mistaken. Protagoras, as depicted in the Theaetetus, does away with the possibility of people genuinely contradicting one another, since all statements are about how things appear to the individual making the statement, and hence all (sincere) statements turn out to be true--for that individual, at that time.
Also, when Protagoras says that each us can judge infallibly how things 'appear' to us, the sense of 'appearance' that Protagoras is using extends beyond the initial restricted sense of phenomenal appearances, e.g., a wind feeling hot or a wall seeming white, to cover beliefs generally. That is, if I believe that "the laws of Athens are just," then Protagoras would say that this is equivalent to "it seems to me that the laws of Athens are just." And since each of us can judge infallibly about our own appearances, I can also know that it is true (for me) that "the laws of Athens are just." The Cyrenaics retain the more restricted sense of 'appearance,' where each of can know infallibly our immediate perceptual states, for instance, knowing that I am having a red experience, but this does not extend to knowledge of laws 'appearing' to be just, or the future 'appearing' to be hopeful.
The later academic and Pyrrhonian skeptics make use of arguments from the relativity of perception to try to refute the position of dogmatists, like the Stoics and the Epicureans, who claim that we can gain knowledge of the external world on the basis of sense-perception. However, although the Cyrenaics might properly be called 'skeptics,' their skepticism differs from the skepticism of the Pyrrhonists in at least three respects.
The first difference is that the Cyrenaics claim that we can have knowledge of the contents of our experiences, while the Pyrrhonists disavow any knowledge whatsoever. However, this difference might not be as significant as it seems, since the Pyrrhonists do acknowledge that we can accurately report how things appear to us--e.g., that the wind appears hot. However, they refuse to say that this qualifies as knowledge, since knowledge concerns how things are, not merely how they appear to us.
The second difference is that the Cyrenaics claim that it is impossible to gain knowledge of the external world, while the Pyrrhonists claim neither that one can nor that one cannot gain such knowledge. The Pyrrhonists would label the Cyrenaic position as a form of 'negative dogmatism,' since the Cyrenaics do advance assertions about the impossibility of knowledge of the external world. This is a type of second-order purported 'knowledge' about the limits of our knowledge, and the Pyrrhonists, as true skeptics, do not make even these types of pronouncements.
Third, although the Cyrenaics do claim that it is impossible to gain knowledge of what the external world is like, it is not as clear that they doubt that there exists an external world, which the Pyrrhonists do. Some sources ascribe to the Cyrenaics the position that whether there is an external world is not known, while others ascribe to them the position that we can know that there is an external world that is the cause of our experiences, but that we cannot know what this world is like. The latter position fits in more smoothly with the way the Cyrenaics conceive of experiences, as effects of external causes ("I am being yellowed"), but has obvious difficulties of its own. (For instance, if we can know nothing about what characteristics objects in the external world have, what basis do we have to think that these objects exist?) However, if this is what the Cyrenaics think, a parallel can be drawn between their position and what Immanuel Kant says about the existence of the noumenal world of 'things in themselves,' which is the unknowable source of the data which ultimately forms our experiences.
Finally, the Cyrenaic position, at least in the limited reports we have concerning it, does not appear to be as fully-developed as that of the later skeptics. The academic and Pyrrhonian skeptics engaged in long controversies with the dogmatists, and as a result, they needed to answer the objections of the dogmatists, e.g., that it is impossible to live as a skeptic, or that skepticism is self-refuting. The Cyrenaics, as far as we know, do not address these questions.
The Cyrenaics are unabashed sensual hedonists: the highest good is my own pleasure, with all else being valuable only as a means to securing my own pleasure, and bodily pleasures are better than mental pleasures. Their iconoclastic theory stands well outside the mainstream of Greek ethical thought, with the traditional virtues of moderation, justice, and friendship being disparaged by them. 3a. The Value and Nature of Pleasure
The Cyrenaics start from the Greek ethical commonplace that the highest good is what we all seek for its own sake, and not for the sake of anything else. This they identify as pleasure, because we instinctively seek pleasure for its own sake, and when we achieve pleasure, we want nothing more. Similarly, pain is bad because we shun it.
When the Cyrenaics say that 'pleasure' is the highest good, they do not mean that pleasure in general in good, so that we should seek to maximize the overall amount of pleasure in the world, as utilitarians say. Instead, they mean that, for each of us, our own pleasure is what is valuable to us, because that is what each of us seeks. Also, each of us can only experience our own pleasures, and not the pleasures of other people. Thus, the Cyrenaic view is a form of egoistic hedonism.
Pleasure and pain are both 'movements,' according to the Cyrenaics: pleasure a smooth motion, and pain a rough motion. The absence of either type of motion is an intermediate state which is neither pleasurable nor painful. This is directed against Epicurus' theory that thehomeostatic state of being free of pain, need and worry is itself most pleasant. The Cyrenaics make fun of the Epicurean theory by saying that this state of being free of desires and pain is the condition of a corpse.
The Cyrenaics admit that there are both bodily pleasures (for example, sexual gratification) and mental pleasures (e.g., delight at the prosperity of one's country), and they maintain, against the Epicureans, that not all mental pleasures are based upon bodily pleasures. However, they exalt bodily over mental pleasures, presumably because bodily pleasures are much more vivid than mental pleasures. They also assert that bodily pains are worse than mental pains, and give as evidence for this claim that criminals are punished with bodily instead of mental pains.
One of the most striking features of Cyrenaic ethics is their assertion that it is pleasure, and not happiness, which is the highest good. Almost all other Greek theorists agree that happiness is the highest good, but disagree about what happiness consists in. Even Epicurus, who is a hedonist, remains within this tradition by asserting that happiness is the same as leading a pleasant life. The Cyrenaics, however, say that what we really seek are individual pleasures, e.g., the pleasure of eating a steak. Happiness, which is thought of as the sum of all of these individual pleasures, is valuable only because of the value of each of the individual pleasures that make it up.
Another striking feature of the Cyrenaic theory is its lack of future-concern. The Cyrenaics advocate going after whatever will bring one pleasure now, enjoying the pleasure while one is experiencing it, and not worrying too much about what the future will bring. Although the Cyrenaics say that prudence is valuable for attaining pleasure, they do not seem much concerned with exercising self-control in pursuing pleasure, or with deferring present pleasures (or undergoing present pains) for the sake of experiencing greater pleasure (or avoiding greater pains) in the future.
This lack of future-concern is not a direct consequence of their hedonism, nor of their privileging of bodily over mental pleasures. If pleasure is the highest good, and one wants to maximize the pleasure in one's life, then the natural position to take is the one Socrates lays out in Plato's dialogue the Protagoras. Socrates describes a type of hedonism in which one uses a 'measuring art' to weigh equally all of the future pleasures and pains one would experience . Although present pleasures might seem more alluring than distant ones, Socrates maintains that this is like an optical illusion in which nearer objects seem larger than distant ones, and that one must correct for this distortion if one is going to plan one's life rationally. Epicurus, likewise, says that the wise person is willing to forgo some particular pleasure if that pleasure will bring one greater pain in the future. Simply indulging in whatever pleasures are close at hand will ultimately bring one unhappiness.
The texts we have do not allow us to obtain with any degree of confidence the reasons that the Cyrenaics have for their advocacy of the pleasures of the moment. There are at least three plausible speculations, however:
The first reason that the Cyrenaics might have for rejecting long-term planning about one's pursuits is that they are skeptical about personal identity across time. If all I have access to are momentary, fluctuating experiences, what reason do I have to think that the 'self' that exists today will be the same 'self' as the person who will bear my name 30 years hence? After all, in most respects, a person at 30 years old is almost completely different from that 'same' person at 10, and the 'same' person at 50 will also be much changed. So, if what I desire is pleasure for myself, what reason do I have to sacrifice my pleasures for the sake of the pleasures of that 'other' person down the temporal stream from myself? Nursing a hangover, or deep in debt, that future self might curse the past self for his intemperance, but what concern is that of mine?
If the Cyrenaics do believe that personal identity does not persist over time, their position would be similar to one espoused by Protagoras in the Theaetetus. Because of the similarities between the Protagorean and Cyrenaic epistemologies, as well as the fact that having such a position would help make sense of the Cyrenaics' focus on pursuing present pleasures, some scholars have attributed this view of personal identity to the Cyrenaics. However, there is little direct evidence that they held such a view, and the way they describe people and objects seems, indeed, to presuppose their identity across time.
The Cyrenaics may also think that planning for the future, and trying to assure happiness by foregoing present pleasures for the sake of the future, is self-defeating. If this is right, then it is not the case that the Cyrenaics think that future pleasures and pains are unimportant, it is simply that they believe that worrying about the future is futile. One gains happiness, and maximizes the pleasure in one's life, not by anxiously planning one's future out, and toiling on behalf of the future, but simply by enjoying whatever pleasures are immediately at hand, without worrying about the long-term consequences.
The Cyrenaics think that "to pile up the pleasures which produce happiness is most unpleasant," because one will need to be choosing things which are painful for the sake of future pleasures. The Cyrenaics instead aim at enjoying the pleasures that are present, without letting themselves be troubled at what is not present, i.e., the past and future. Epicurus thinks that the memory of past pleasures, and the expectation of future pleasures, are themselves most pleasant, and hence he emphasizes the importance of careful planning in arranging what one will experience in the future. The Cyrenaics, however, deny this, saying that pleasures are pleasant only when actually being experienced.
Finally, the Cyrenaics lack of future-concern may result from radically relativizing the good to one's present preferences. It's reported that Aristippus "discerned the good by the single present time alone," and later Cyrenaics assert that there is no telos--goal or good--to life asa whole; instead, particular actions and desires each aim at some particular pleasure. So the notion of some overall goal or good for one's entire life is rejected and is replaced by a succession of short-terms goals. As one's desires change over time, what is good for you at that time likewise changes, and at each moment, it makes sense to try to satisfy the desires that one has at that time, without regard to the desires one may happen to have in the future.
If the Cyrenaics thought that to choose rationally is to endeavor to maximize the fulfillment of one's present preferences, their position would be analogous to the model of economic rationality put forward by current philosophers like David Gauthier.
In ancient times, the Cyrenaics were among the most dismissive of traditional Greek morality. They say that nothing is just or base by nature: what is just or base is set entirely by the customs and conventions of particular societies. So, for instance, there is nothing in the world or in human nature that makes incest, or stealing, or parricide wrong in themselves. However, these things become base in a particular society because the laws and customs of that society designate those practices as base. You should normally refrain from wrong-doing, not because wrong-doing is bad in itself, but because of the punishments that you will suffer if you are caught.
Many of the stories surrounding Aristippus stress his willingness to do things that were considered demeaning or shocking, like putting on a woman's robes when the king commands it, or exposing his child to die with no remorse when it was an inconvenience. Although most of these stories are malicious and probably untrue, they do seem to have a basis in the Cyrenaics' disregard of conventions of propriety when they think they can get away with it. All pleasures are good, they say, even ones that result from unseemly behavior.
The Cyrenaic attitude toward friendship also is consistent with their egoistic hedonism and well outside the traditional attitudes toward friendship. Friendship, according to the Cyrenaics, is entered into for self-interested motives. That is, we obtain friends simply because we believe that by doing so we will be in a better position to obtain pleasure for ourselves, not because we think that the friendship is valuable for its own sake, or because we love our friend for his own sake.
Around the time of Epicurus, a number of offshoot sects of Cyrenaicism sprung up. They seemed to have been concerned mainly with modifying or elaborating Cyrenaic ethics.
Hegesias is an extremely pessimistic philosopher. He maintains that happiness is impossible to achieve, because the body and mind are subject to a great deal of suffering, and what happens to us is a result of fortune and not under our control. Pleasure is good, and pain evil, but life as such is neither good nor evil. It is reported (maybe spuriously) that Hegesias was known as the 'death-persuader,' and that he was forbidden to lecture because so many members of his audience would kill themselves after listening to him.
Hegesias stresses that every action is done for entirely self-interested motives, and because of this, he denies that friendship exists. This assumes, of course, that one cannot truly be a friend if one enters into the friendship for entirely self-interested reasons.
Anniceris moderated the extreme psychological egoism of Hegesias. He says that friendship does exist, that we should not cherish our friends merely for the sake of their usefulness to us, and that we will willingly deprive ourselves of pleasures because of our love of our friends.
He also says, however, that our end is our own pleasure, and that the happiness of our friend is not desirable for its own sake, since we feel only our own pleasure, not that of our friend. It is not clear how he makes these different parts of his theory consistent with one another.
Theodorus was a pupil of Anniceris. His main innovation is the rejection of the thesis that pleasure and pain are the things that are intrinsically good and evil. Instead, he says that these are intermediates, and that the experience of joy is the highest good, and the feeling of grief the worst evil. (Theodorus may mean to relegate only bodily pleasures and pains to the status of intermediates, since it is natural to think of joy as a mental pleasure and grief as a mental pain.)
He also believes that friendship does not exist, since wise people are self-sufficient and do not need friends, while the unwise enter into friendship merely to satisfy their needs (and hence are not really friends). He also says that acts like adultery, theft and sacrilege are sometimes allowable, since these acts are not bad by nature, but are simply looked down upon because of societal prejudices, which are engendered in order to keep the masses in line.
None of Cyrenaics' own writings survive. Thus, in order to reconstruct their views, we need to rely on secondary and tertiary sources which summarize the outlines of Cyrenaic doctrines, or mention the Cyrenaics in passing while discussing some other topic. These sources are not always reliable, and they are often sketchy, so our knowledge of the Cyrenaics is incomplete and tentative. In particular, our sources often mention what the philosophical position of a Cyrenaic is, without recording what his arguments were for that position.
Our main source for Cyrenaic epistemology is Sextus Empiricus, a doctor and Pyrrhonian skeptic who probably lived in the second century A.D. He is a careful and intelligent writer, although he is a fairly late source and is also sometimes polemical. He mentions the Cyrenaics in several places, but his most extended discussion of them occurs in Against the Professors VII 190-200. Another important source for Cyrenaic epistemology is the treatise Against Colotes, by the essayist Plutarch (c. 50-120 A.D.), a Platonist. The main topic of the essay is an attack on Epicurean epistemology, but Plutarch also deals with the Epicurean criticisms of the Cyrenaics in 1120c-1121e.
Our main source for the lives and ethics of the Cyrenaics is Diogenes Laertius, who probably lived in the third century A.D. His 10-book Lives of the Philosophers is a gossipy compendium of what other people have said about the lives and thought of many philosophers. Book 2 includes a discussion of Aristippus and the Cyrenaics. It is stuffed with reports of the Cyrenaics' scandalous behavior and witty repartee, almost all of which are probably scurrilous, but it also has a valuable summary of the Cyrenaics' ethical doctrines.
This is not meant as comprehensive bibliography; rather, it's a selection of a few recent books and articles to read for those who want to learn more about the Cyrenaics. The books and articles listed below have extensive bibliographies for those looking for more specialized and scholarly publications.
Tim O'Keefe Email: (see web page) Georgia State University U. S. A.
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NATO – Wikipedija, prosta enciklopedija
Posted: at 6:59 am
Organizacija severnoatlantskega sporazuma, Organizacija severnoatlantske pogodbe[1] ali tudi Severnoatlantska pogodbena zveza (angleko North Atlantic Treaty Organisation, kratica Nato ali NATO; francosko Organisation du Trait de l'Atlantique Nord, kratica Otan ali OTAN) je mednarodna vojako-politina organizacija drav za sodelovanje na podroju obrambe, ki je bila ustanovljena leta 1949.
Leta po drugi svetovni vojni so prinesla hitro stopnjevanje trenja med deelami vzhodnega politinega bloka (komunistinimi sistemi) in deelami Zahoda (demokratinimi sistemi zahodne Evrope in severne Amerike). Tako vzhodna kot zahodna stran sta bili mnenja, da nasprotna sila resno ogroa njun obstoj in blaginjo. Kot posledica sta bili v obeh blokih ustanovljeni obrambni zvezi potencialno ogroenih drav: leta 1949 zveza Nato na Zahodu in est let kasneje Varavski pakt na Vzhodu. Ustanovitev zveze Nato, sicer varnostno zagotovilo pred grozeo ofenzivo komunistinih sil, je dobila neposreden povod z blokado Berlina s strani Sovjetov. Na ustanovnem zasedanju zveze Nato so bile udeleene drave ustanoviteljice: Belgija, Danska, Francija, Islandija, Italija, Kanada, Luksemburg, Nizozemska, Norveka, Portugalska, Velika Britanija in ZDA.
V prvem letu delovanja je Nato na prvem mestu - v oeh evropskih drav - pomenil zagotovilo amerike pomoi ob morebitnem spopadu. Junija 1950, dobro leto po ustanovitvi pakta, se je v Koreji razplamtel prvi izmedobrobnihspopadov obeh velesil. Moan udarec severnokorejske vojske z izdatno podporo Kitajske in ZSSR je tril ob junokorejske, z Ameriani ojaane sile. Krvava vojna se je konala tako reko brez zmagovalca, prinesla pa je nove politine in geografske razsenosti zveze Nato. Ta je zaela pospeene priprave na iritev, do katere je prilo leta 1952: v organizacijo sta bili zaradi strateke lege vkljueni Grija in Turija, dravi, ki sta se zajedali globoko v june obronke vzhodnega bloka. Tri leta kasneje je bila kot odgovor na blokado Berlina v pakt pod posebnimi pogoji vkljuena tudi Zahodna Nemija.
Skozi obdobje hladne vojne se je pomen zveze Nato predvsem v smislu varnosti vseskozi veal. Prihajalo je do vse vejih in pogostejih zaostrovanj med zahodnim in vzhodnim blokom, slednji pa je sasoma razvil lastno jedrsko oroje, s imer se je izenaila vojaka mo obeh zvez. Posledino se je med evropskimi deelami pojavil strah, ki je izviral iz dejstva, da v primeru sovjetske invazije ZDA zaradi lastne varnosti utegnejo odkloniti pomo - prilo je do prvih manjih sporov in razhajanj med Evropo in ZDA. Tako je leta 1966 svoje lanstvo zamrznila de Gaulle-ova Francija.
Oboroevalna tekma je bila v polnem zagonu, krize pa so se vrstile: vietnamska vojna, kubanska kriza in druga nekoliko manja trenja so le e poveevala nesoglasja med Zahodom in Vzhodom. S stalnim razvojem novega in mogonejega oroja se je vseskozi dral strah med obema velesilama, s tem pa tudi nekakno ravnoteje, ki je tako Sovjete kot Ameriane sililo k neuporabi svojih medcelinskih raket z jedrskimi konicami. V letu 1982 je po ukinitvi panskega faizma prilo do krepitve Nato pakta z novo lanico.
Zaostreno stanje med velesilama je poasi zaelo topliti v poznih osemdesetih letih 20. stoletja. Prilo je do podpisa Sporazuma o balistinih raketah dolgega dosega, ki je narekoval unienje vseh raket z dosegom nad 500 km, ter konno do razpada Varavskega pakta leta 1989.
Sledilo je post-hladnovojno obdobje zveze Nato.
Abecedno urejene drave lanice od ustanovitve leta 1949 ali z letom pristopa v oklepaju:
Grija in Turija sta v organizacijo vstopili februarja 1952. Nemija se je prikljuila leta 1955 kot Zahodna Nemija, zdruitev obeh Nemij leta 1990 pa je razirilo zvezo tudi na obmoje nekdanje Vzhodne Nemije, ki je bila lanica Varavskega pakta. panija je vstopila 30. maja 1982, e tri nekdanje lanice Varavskega pakta - Poljska, Madarska in eka - pa so se zvezi prikljuile 12. marca 1999.
Francija je e vedno lanica zveze NATO, vendar se je leta 1966 umaknila iz skupne vojake poveljnike strukture. Islandija je edina lanica zveze NATO, ki nima lastne vojske, pristopila pa je pod pogojem, da ji je tudi ne bo treba ustanoviti.
V letih 1999-2000 so drave NATA imele:
... kar znaa 1.212 glavnih vojakih ladij.
Zlasti v asu vstopanja Slovenije v Severnoatlantsko zvezo leta 2003 in prej so se veinoma v civilni drubi pojavljale mnoge kritike zveze in vstopanja Slovenije v to zvezo. Te kritike so bile ob vzniku civilnih pobud proti zvezi Nato (Reci ne Nato, Dost je) zdruene v temeljnih deset tok[navedi vir]:
Na te kritike je vladna stran (Slovenija in Nato) odgovorila z naslednjimi protiargumenti:
Te utemeljitve so v javni razpravi na koncu tudi prevagale, kar se je pokazalo na referendumu 23. marca 2003, ko je kar dve tretjini glasujoih (66,02%) podprlo vstop Slovenije v Severnoatlantsko zvezo.
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NATO, Russia to hold parallel military drills in the Balkans …
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Russian President Vladimir Putin (c) and his Serbian counterpart Tomislav Nikolic (3rd R) watch a military parade in Belgrade, Serbia, on October 16, 2014..
VASILY MAXIMOV/AFP/Getty Images
BELGRADE, Serbia - NATO is holding an emergency exercise drill in Montenegro while Russian troops will participate in a war game in Serbia as the two Balkan neighbors seem to be heading in different directions strategically. The moves come amid mounting tensions between Russia and the West over a variety of geopolitical issues.
The five-day drill in Montenegro that started Monday includes fighting floods and chemical attacks. It will involve 680 unarmed personnel from seven NATO countries and 10 partner states.
The 13-day armed exercise in Serbia, dubbed The Slavic Brotherhood 2016, begins Wednesday. It will include 150 Russian paratroopers, 50 air force staffers, 3 transport planes and an unspecified number of troops from Serbia and Belarus, Russias Defense Ministry said.
Both Serbia and Montenegro - a single state before their split in 2006 - are traditional Russian Christian Orthodox allies. But since the split, Montenegro has pursued pro-Western policies, while Serbia has been struggling to wrestle away from the Moscow grip.
Montenegro has been invited to join NATO, despite strong opposition from Russia. Serbia is under strong pressure from the Kremlin not to join the Western military alliance or the European Union.
Serbia, a NATO partner, has held exercises with the Western alliance, but not such a large one or with foreign troops and equipment participating on its soil.
Montenegrin officials have accused Russia of standing behind an alleged coup on election day earlier in October to topple the pro-Western government because of its NATO bid. Some 20 Serbian citizens were arrested in Montenegro during the vote, suspected of trying to stage the coup, while Serbian authorities reportedly deported an unspecified number of Russian operatives from their territory.
2016 CBS Interactive Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The Associated Press contributed to this report.
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Republicans rip Trump over NATO plan – POLITICO
Posted: at 6:59 am
Donald Trump has long questioned whether other NATO states were carrying their share of the financial and military burdens that come with the alliance.
One GOP lawmaker tells POLITICO, 'Comments like this are not only ill-informed, theyre dangerous.'
By Nahal Toosi
07/21/16 07:56 AM EDT
Updated 07/21/16 03:30 PM EDT
Donald Trump's latest broadside against NATO, the military alliance that has long served as a pillar of Western unity, has further aggravated the disunity in the Republican Party as he prepares to accept its nomination for president.
In an interview with The New York Times, Trump said the United States shouldn't automatically come to the defense of fellow NATO members if they are attacked unless those countries have paid their bills to the alliance. That approach flies in the face of one of NATO's bedrock principles, Article 5, which requires NATO states to come to the aid of a fellow member under assault.
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The comments drew scorn not only from American allies but also from several top Republicans, undermining the party's efforts to project unity during its national convention this week in Cleveland. They were published less than a day before Trump is due to deliver a major speech at the convention, and they further fueled the perception that Trump is a lackey for Russian President Vladimir Putin.
"I disagree with that," Senate Majority Leader Mitch McConnell, who was in Cleveland, said of Trump's comments. "NATO is the most important military alliance in world history. I want to reassure our NATO allies that if any of them get attacked, we'll be there to defend them."
Republican Rep. Adam Kinzinger of Illinois, speaking during a POLITICO panel event at the convention, said Trump's remarks made it harder for him to vote for the real estate mogul come November.
"You have allies right now, I mean I have friends that, you know, serve in parliament in places like Estonia, that every day worry about the Russians deciding that this is the time to re-annex and take them back, said Kinzinger, a former Air Force pilot. And comments like this are not only ill-informed, theyre dangerous.
Trump has long offered a radically different view of U.S. engagement with the world than many in his own party hold one that is defined primarily in economic terms and which does not hold treaties sacrosanct.
In the Times interview, Trump also said he would not chide authoritarian leaders for cracking down on civil liberties or their political rivals; that he'd pull the U.S. out of the North American Free Trade Agreement if Canada and Mexico didn't agree to better terms; and that he might withdraw U.S. troops deployed around the world, even from sensitive areas such as the Korean peninsula.
But the Manhattan billionaire's comments on NATO were unusually striking. Trump, who has often questioned whether other NATO states are carrying their share of the financial and military burdens that come with the alliance, said that if he became president the U.S. would come to the assistance of a member state under attack only if it has fulfilled their obligations to us.
The North Atlantic Treaty Organization, established in 1949, has 28 members. The first time NATO invoked Article 5 was after the Sept. 11, 2001, attacks on the United States, and America's NATO allies have since helped fight the Taliban and Al Qaeda in Afghanistan. Many NATO members also are involved in the U.S.-led coalition battling the Islamic State terrorist network, and a number of their representatives were in Washington on Thursday for a meeting of the coalition, making the timing of Trump's comments all the more sensitive.
The international blowback was swift.
"Solidarity among allies is a key value for NATO," the military alliance's secretary general, Jens Stoltenberg, said in a statement as word spread of Trump's remarks. "We defend one another. ... Two world wars have shown that peace in Europe is also important for the security of the United States."
Trump's comments were especially unnerving to smaller NATO countries, such as the Baltic states of Estonia, Latvia and Lithuania, who in recent years have begun to fear Russia's military aims. (Trump was specifically asked about the threat to the Baltic states in the Times interview.)
Toomas Hendrik Ilves, the president of Estonia, tweeted his dismay early Thursday, saying, "Estonia is 1 of 5 NATO allies in Europe to meet its 2% def expenditures commitment. Fought, with no caveats, in NATO's sole Art 5 op. in Afg." He added: "We are equally committed to all our NATO allies, regardless of who they may be. That's what makes them allies."
Latvia's foreign minister, Edgars Rinkevics, meanwhile, stressed to POLITICO in a phone interview that his country has aided the U.S. in Afghanistan and has been steadily increasing its defense spending to align with its NATO commitments.
"I am a politician myself and I always make a distinction when it comes to a campaign and when it comes to the trappings of the office," Rinkevics said while declining to comment directly on Trump. He added, however, "We take those commitments that have been made by the U.S. government seriously."
Trump aides on Thursday tried to contain the fallout from his remarks. His campaign chairman, Paul Manafort, insisted that Trump simply wants NATO to adjust to new security realities, where threats are often from nonstate actors.
"What Mr. Trump has said consistently is that he thinks NATO needs to be modernized and brought into the world of the 21st century where terrorism and [the Islamic State], which didn't exist when NATO was created, are taken into account in the way they deal with things," he said.
Trump is hardly alone in his concern that some NATO members do not devote enough resources to the alliance and that the U.S. carries more than its share of the burden. Even President Barack Obama has gently reproached some NATO states for not living up to their commitment of devoting 2 percent of their GDP to defense, saying in a speech in April that "sometimes Europe has been complacent" about its security.
Trump adviser Sam Clovis told POLITICO that the candidate was in effect putting NATO members on notice "We're putting a marker out there." He added, however, that the Trump's comments were about the exploring the opportunity to "reinvest in NATO" and not a "hostile confrontation."
Still, Article 5 is not meant to apply only to members who have paid all their dues. And even if Trump were to never actually follow through on his pay-for-protection philosophy, the simple fact that he would hint at it publicly, observers said, could rattle allies and fray diplomatic relations.
"I dont think hes given any serious thought to the substance of the issue," said Kurt Volker, a former U.S. ambassador to NATO. "Its one thing to complain that theyre not doing enough and they need to pull their share, which they do. But another is to question the U.S. commitment. The reason thats so important is certainty how we would behave and others behave is what provides stability. Its what provides deterrent. Its what guarantees that well never have to fight."
Trump's NATO comments were a gift to Democrats seeking to portray him as a threat to the world order.
Presumptive Democratic presidential nominee Hillary Clinton's campaign put out a statement invoking Republican darling Ronald Reagan to blast Trump the latest sign of how the Democrat is trying to take advantage of the divisions Trump has sowed within the GOP.
"Ronald Reagan would be ashamed. Harry Truman would be ashamed. Republicans, Democrats and Independents who help build NATO into the most successful military alliance in history would all come to the same conclusion: Donald Trump is temperamentally unfit and fundamentally ill-prepared to be our commander in chief," Clinton senior policy adviser Jake Sullivan said in the statement.
Virginia Sen. Tim Kaine, a potential vice presidential pick for Clinton, said he was "stunned" to learn of Trump's comments. "Is the new rule that your word isn't your bond?" he asked at an immigration-related event in his home state.
White House spokesman Josh Earnest, meanwhile, tried to reassure America's partners. "There should be no mistake or miscalculation made about this countrys commitment to our trans-Atlantic alliance," he said.
A number of Trump's critics said Trump's statements appear to be exactly what Putin would want to hear. Putin has long felt somewhat threatened by NATO's presence, especially as former Soviet states have sought to join the alliance.
Trump has been complimentary toward Putin; he told the Times that he and Putin "will get along very well." The Republican's team was reported to have pressured the party's platform-writing committee to remove references about the U.S. coming to the aid of Ukraine, a former Soviet country that Russia invaded in 2014 and has been locked in a battle over territory with since.
"Im 100 percent certain how Russian President Putin feels hes a very happy man," Sen. Lindsey Graham of South Carolina, a prominent Republican critic of Trump, said of the GOP nominee's remarks.
Trump's vice presidential pick, Indiana Gov. Mike Pence, also sought to defend him Thursday as word spread of his NATO remarks.
I have every confidence that Donald Trump will see to it that the United States of America stands by our allies and lives up to our treaty obligations," Pence told "Fox & Friends." "That being said, I think he makes an enormously important point that I think resonates with millions of Americans that at a time where we have $19 trillion in national debt, that we need to begin to look to our allies around the world to step up and pay their fair share.
But the Clinton team was all too happy to point out the daylight between Trump and Pence, as the former secretary of state gears up to announce her own choice of running mate. Sullivan's statement noted that Pence also had spoken of the importance of America's allies in his speech at the convention on Wednesday.
Tonight, Mike Pence said Donald Trump would stand with our allies. Tonight, Donald Trump flatly contradicted him," Sullivan said.
Seung-min Kim, Ryan Heath, Benjamin Oreskes, Giulia Paravicini, Michael Schwab, Louis Nelson, Burgess Everett, Daniel Ducassi and Bianca Padro Ocasio contributed to this report.
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NATO | Armed Assault Wiki | Fandom powered by Wikia
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NATO flag
The North Atlantic Treaty Organization is an intergovernmental military alliance based on the North Atlantic Treaty which was signed on 4 April 1949.
The organization constitutes a system of collective defense whereby its member states agree to mutual defense in response to an attack by any external party. NATO's headquarters are located in Haren, Brussels, Belgium.
Decades of economic and political turbulence across member states have left NATO weakened, and facing a strategic paradigm shift. With CSAT political and military influence dominating from the Pacific to the Mediterranean, NATO seeks to consolidate their diminished forces around traditional strongholds. As tensions continue to grow in the east, a US-led joint NATO-AAF peacekeeping force stationed on Stratis - Task Force Aegis - is in the middle of a staged draw-down.
NATO forces consisting of elements from the Army of the Czech Republic and German Kommando Spezialkrafte were sent to Takistan to assist the US Army.
The North Atlantic Treaty Organization (NATO) makes up of Arma 3s "western" forces, including many elements from the US Army and multi-national unit called CTRG.
NATO forces are sent to Tanoa in that same year.
US Army and British UKSF soldiers are very similarly equipped, as part of an international effort to standardize NATO equipment. Both sub-factions use Carrier Rigs (Crye Armor Chassis), ECH helmets, and are equipped with MX series service rifles. US Army units wear MTP Combat Fatigues (Crye G2 pants and combat shirts, Ringers gloves, as well as Lowa boots), while British UKSF wear similar uniforms with a Triangular Dazzle pattern. US Army gear is often brown or green with numerous variations, while British UKSF wear coyote-brown vests and headgear sprayed over with snakeskin.
The MX 6.5 mm, designed by CMMG, Inc. chambers the 6.5x39 mm non-case round. The MX series rifle is standard issue for NATO forces, and comes in 4 versions: a standard rifle (with an optional underslung 3GL), a carbine for non-combat personnel such as officers and vehicle crew, a squad automatic rifle, and a marksman rifle. The P07 is the standard sidearm for NATO units. The MXM 6.5 mm is used as a NATO marksman rifle, alongside the Mk18 7.62 marksman rifle.
NATO forces use the Hunter as a standard ground utility vehicle. It is a medium sized MRAP made for multipurpose use and comes in unarmed, RCWS HMG, and RCWS GMG variants. The HEMTT is an 8-wheeled truck used for multi-purpose roles such as troop and cargo transport. Special operations and utility units use quadbikes for general transport and other roles.
For combat the M2A1 Slammer (Licensed copy of the Israeli Merkava MBT) functions as NATO's Main Battle Tank for ground combat operations in the region. The AMV-7 Marshallis used as an amphibious APC for ground troops, in addition to the IFV-6c Panther(Licensed copy of the Israeli Namer IFV)Infantry Fighting Vehicle. The IFV-6a Cheetah serves as self propelled anti-air support, while the M4 Scorcher and M5 Sandstorm MLRS platforms are used as mobile artillery systems.
NATO aircraft are mostly American and utilize geometric stealth radar-resistant technologies. NATO helicopters include the AH-99 Blackfoot light helicopter gunship (revival of the prototype RAH-66 Comanche), MH-9 Hummingbird and AH-9 Pawnee (both updated versions of the Littlebird family), the CH-67 Huron (modernized stealth variant of CH-47 Chinook) and the UH-80 Ghosthawk (stealth variant of the UH-60 Blackhawk). NATO fixed-wing assets include the A-164 Wipeout (updated stealth version of the A-10 Thunderbolt).
NATO Naval forces seen in the Altis Conflict consist of Speedboats, Assault Boats, and SDV (Swimmer Delivery Vehicle) submersibles. British UKSF are seen to operate from the HMS Proteus, an Astute-Class Submarine.
NATO forces operate the Stomper UGV as both an unarmed logistics platform and an armed combat vehicle, mounting a 12.7 mm HMG and a 40 mm GMG in a RCWS. NATO troops also employ the AR-2 Darter Mircro-UAV and the MQ-4A Greyhawk UCAV.
NATO special operations deployed to the Republic of Altis and Stratis theater consist of reconnaissance, aquatic, and sniper teams.
Sniper teams are usually fielded in groups of two, made up of a sniper and a spotter. Said personnel make use of Gillie Suits based off of standard MTP Combat Fatigues, Chest Rigs, and Balaclavas. Snipers are armed with camouflaged M320 LRR sniper rifles and suppressed P07s, while spotters field suppressed MX rifles and suppressed P07s. Snipers are equipped with Rangefinders, while Spotters carry Laser Designators. Scout-sniper operations usually consist of very slow, stealthy movement and can last days on end. Tasks include observing and relaying enemy movement, as well as engaging high value targets or providing fire support for friendly forces in the vicinity.
Recon teams are equipped with lighter gear than standard infantry. Booniehats, Beanies, and other light head-wear along with Chest Rigs without ballistic protection are the norm. Recon teams deploy with suppressed weaponry.
NATO divers are equipped with SDAR underwater rifles and suppressed P07 pistols. They use Rebreathers and wear black Wetsuits.
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Pandora Internet Radio – Listen to Free Music You’ll Love
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[75, 77, 114, 70, 103, 66, 90, 105, 89, 127, 64, 112, 81, 113, 103, 93, 80, 92, 119, 84, 65, 122, 65, 80, 108, 94, 100, 82, 122, 96, 92, 124, 88, 122, 104, 97, 81, 70, 115, 90, 119, 121, 97, 65, 109, 96, 122, 118, 80, 116, 65, 108, 104, 102, 96, 113, 109, 122, 103, 80, 102, 78, 103, 120, 92, 108, 123, 89, 126, 72, 77, 101, 100, 126, 74, 101, 69, 84, 77, 88, 87, 116, 78, 119, 127, 93, 64, 77, 73, 77, 88, 67, 83, 127, 93, 88, 121, 65, 126, 108, 98, 104, 86, 87, 69, 119, 101, 84, 100, 88, 110, 99, 75, 80, 115, 113, 80, 97, 106, 123, 82, 90, 83, 119, 106, 111, 109, 121, 73, 121, 78, 91, 90, 101, 64, 85, 99, 108, 100, 76, 114, 86, 103, 88, 68, 92, 100, 70, 92, 125, 78, 116, 69, 126, 116, 87, 121, 90, 112, 114, 87, 99, 120, 108, 109, 82, 98, 117, 123, 100, 126, 95, 127, 87, 92, 99, 72, 69, 107, 98, 90, 110, 111, 104, 87, 83, 123, 127, 98, 86, 100, 86, 86, 117, 110, 123, 108, 73, 86, 124, 120, 81, 87, 96, 67, 120, 81, 101, 107, 78, 126, 76, 93, 95, 92, 122, 73, 90, 106, 68, 95, 113, 103, 73, 75, 117, 99, 122, 77, 111, 123, 119, 74, 65, 74, 120, 74, 66, 64, 75, 102, 113, 78, 68, 76, 64, 95, 108, 98, 74, 84, 105, 64, 72, 70, 102, 121, 82, 118, 111, 98, 106, 109, 117, 100, 91, 89, 88, 107, 125, 72, 96, 69, 122, 115, 122, 70, 101, 112, 65, 97, 114, 100, 73, 118, 93, 67, 127, 119, 79, 73, 101, 83, 112, 108, 91, 82, 94, 118, 82, 89, 94, 116, 116, 79, 68, 83, 124, 81, 71, 101, 124, 87, 117, 73, 116, 95, 100, 116, 123, 85, 93, 90, 102, 112, 68, 109, 93, 120, 113, 68, 78, 64, 111, 87, 122, 71, 125, 97, 65, 122, 76, 100, 100, 126, 90, 109, 121, 90, 83, 87, 117, 100, 70, 86, 97, 125, 76, 97, 73, 111, 116, 92, 108, 74, 87, 65, 122, 106, 124, 92, 111, 127, 115, 81, 94, 117, 125, 69, 109, 90, 104, 126, 75, 73, 69, 106, 81, 106, 93, 104, 67, 69, 89, 89, 120, 93, 96, 78, 124, 64, 103, 102, 119, 105, 127, 127, 78, 123, 77, 107, 84, 74, 114, 115, 111, 125, 116, 73, 92, 116, 84, 110, 75, 91, 80, 106, 83, 80, 82, 66, 73, 107, 111, 90, 115, 111, 78, 88, 76, 77, 110, 88, 82, 102, 78, 116, 93, 80, 104, 115, 114, 116, 104, 72, 115, 105, 104, 88, 107, 85, 82, 77, 93, 78, 80, 116, 83, 78, 111, 82, 98, 65, 102, 99, 115, 110, 104, 97, 88, 86, 87, 117, 88, 98, 82, 101, 97, 93, 79, 101, 105, 82, 85, 83, 123, 106, 111, 68, 79, 100, 95, 87, 98, 71, 116, 99, 68, 71, 115, 75, 78]
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Medical genetics – Wikipedia
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Medical genetics is the branch of medicine that involves the diagnosis and management of hereditary disorders. Medical genetics differs from human genetics in that human genetics is a field of scientific research that may or may not apply to medicine, while medical genetics refers to the application of genetics to medical care. For example, research on the causes and inheritance of genetic disorders would be considered within both human genetics and medical genetics, while the diagnosis, management, and counselling people with genetic disorders would be considered part of medical genetics.
In contrast, the study of typically non-medical phenotypes such as the genetics of eye color would be considered part of human genetics, but not necessarily relevant to medical genetics (except in situations such as albinism). Genetic medicine is a newer term for medical genetics and incorporates areas such as gene therapy, personalized medicine, and the rapidly emerging new medical specialty, predictive medicine.
Medical genetics encompasses many different areas, including clinical practice of physicians, genetic counselors, and nutritionists, clinical diagnostic laboratory activities, and research into the causes and inheritance of genetic disorders. Examples of conditions that fall within the scope of medical genetics include birth defects and dysmorphology, mental retardation, autism, and mitochondrial disorders, skeletal dysplasia, connective tissue disorders, cancer genetics, teratogens, and prenatal diagnosis. Medical genetics is increasingly becoming relevant to many common diseases. Overlaps with other medical specialties are beginning to emerge, as recent advances in genetics are revealing etiologies for neurologic, endocrine, cardiovascular, pulmonary, ophthalmologic, renal, psychiatric, and dermatologic conditions.
In some ways, many of the individual fields within medical genetics are hybrids between clinical care and research. This is due in part to recent advances in science and technology (for example, see the Human genome project) that have enabled an unprecedented understanding of genetic disorders.
Clinical genetics is the practice of clinical medicine with particular attention to hereditary disorders. Referrals are made to genetics clinics for a variety of reasons, including birth defects, developmental delay, autism, epilepsy, short stature, and many others. Examples of genetic syndromes that are commonly seen in the genetics clinic include chromosomal rearrangements, Down syndrome, DiGeorge syndrome (22q11.2 Deletion Syndrome), Fragile X syndrome, Marfan syndrome, Neurofibromatosis, Turner syndrome, and Williams syndrome.
In the United States, physicians who practice clinical genetics are accredited by the American Board of Medical Genetics and Genomics (ABMGG).[1] In order to become a board-certified practitioner of Clinical Genetics, a physician must complete a minimum of 24 months of training in a program accredited by the ABMGG. Individuals seeking acceptance into clinical genetics training programs must hold an M.D. or D.O. degree (or their equivalent) and have completed a minimum of 24 months of training in an ACGME-accredited residency program in internal medicine, pediatrics, obstetrics and gynecology, or other medical specialty.[2]
Metabolic (or biochemical) genetics involves the diagnosis and management of inborn errors of metabolism in which patients have enzymatic deficiencies that perturb biochemical pathways involved in metabolism of carbohydrates, amino acids, and lipids. Examples of metabolic disorders include galactosemia, glycogen storage disease, lysosomal storage disorders, metabolic acidosis, peroxisomal disorders, phenylketonuria, and urea cycle disorders.
Cytogenetics is the study of chromosomes and chromosome abnormalities. While cytogenetics historically relied on microscopy to analyze chromosomes, new molecular technologies such as array comparative genomic hybridization are now becoming widely used. Examples of chromosome abnormalities include aneuploidy, chromosomal rearrangements, and genomic deletion/duplication disorders.
Molecular genetics involves the discovery of and laboratory testing for DNA mutations that underlie many single gene disorders. Examples of single gene disorders include achondroplasia, cystic fibrosis, Duchenne muscular dystrophy, hereditary breast cancer (BRCA1/2), Huntington disease, Marfan syndrome, Noonan syndrome, and Rett syndrome. Molecular tests are also used in the diagnosis of syndromes involving epigenetic abnormalities, such as Angelman syndrome, Beckwith-Wiedemann syndrome, Prader-willi syndrome, and uniparental disomy.
Mitochondrial genetics concerns the diagnosis and management of mitochondrial disorders, which have a molecular basis but often result in biochemical abnormalities due to deficient energy production.
There exists some overlap between medical genetic diagnostic laboratories and molecular pathology.
Genetic counseling is the process of providing information about genetic conditions, diagnostic testing, and risks in other family members, within the framework of nondirective counseling. Genetic counselors are non-physician members of the medical genetics team who specialize in family risk assessment and counseling of patients regarding genetic disorders. The precise role of the genetic counselor varies somewhat depending on the disorder.
Although genetics has its roots back in the 19th century with the work of the Bohemian monk Gregor Mendel and other pioneering scientists, human genetics emerged later. It started to develop, albeit slowly, during the first half of the 20th century. Mendelian (single-gene) inheritance was studied in a number of important disorders such as albinism, brachydactyly (short fingers and toes), and hemophilia. Mathematical approaches were also devised and applied to human genetics. Population genetics was created.
Medical genetics was a late developer, emerging largely after the close of World War II (1945) when the eugenics movement had fallen into disrepute. The Nazi misuse of eugenics sounded its death knell. Shorn of eugenics, a scientific approach could be used and was applied to human and medical genetics. Medical genetics saw an increasingly rapid rise in the second half of the 20th century and continues in the 21st century.
The clinical setting in which patients are evaluated determines the scope of practice, diagnostic, and therapeutic interventions. For the purposes of general discussion, the typical encounters between patients and genetic practitioners may involve:
Each patient will undergo a diagnostic evaluation tailored to their own particular presenting signs and symptoms. The geneticist will establish a differential diagnosis and recommend appropriate testing. Increasingly, clinicians use SimulConsult, paired with the National Library of Medicine Gene Review articles, to narrow the list of hypotheses (known as the differential diagnosis) and identify the tests that are relevant for a particular patient. These tests might evaluate for chromosomal disorders, inborn errors of metabolism, or single gene disorders.
Chromosome studies are used in the general genetics clinic to determine a cause for developmental delay/mental retardation, birth defects, dysmorphic features, and/or autism. Chromosome analysis is also performed in the prenatal setting to determine whether a fetus is affected with aneuploidy or other chromosome rearrangements. Finally, chromosome abnormalities are often detected in cancer samples. A large number of different methods have been developed for chromosome analysis:
Biochemical studies are performed to screen for imbalances of metabolites in the bodily fluid, usually the blood (plasma/serum) or urine, but also in cerebrospinal fluid (CSF). Specific tests of enzyme function (either in leukocytes, skin fibroblasts, liver, or muscle) are also employed under certain circumstances. In the US, the newborn screen incorporates biochemical tests to screen for treatable conditions such as galactosemia and phenylketonuria (PKU). Patients suspected to have a metabolic condition might undergo the following tests:
Each cell of the body contains the hereditary information (DNA) wrapped up in structures called chromosomes. Since genetic syndromes are typically the result of alterations of the chromosomes or genes, there is no treatment currently available that can correct the genetic alterations in every cell of the body. Therefore, there is currently no "cure" for genetic disorders. However, for many genetic syndromes there is treatment available to manage the symptoms. In some cases, particularly inborn errors of metabolism, the mechanism of disease is well understood and offers the potential for dietary and medical management to prevent or reduce the long-term complications. In other cases, infusion therapy is used to replace the missing enzyme. Current research is actively seeking to use gene therapy or other new medications to treat specific genetic disorders.
In general, metabolic disorders arise from enzyme deficiencies that disrupt normal metabolic pathways. For instance, in the hypothetical example:
Compound "A" is metabolized to "B" by enzyme "X", compound "B" is metabolized to "C" by enzyme "Y", and compound "C" is metabolized to "D" by enzyme "Z". If enzyme "Z" is missing, compound "D" will be missing, while compounds "A", "B", and "C" will build up. The pathogenesis of this particular condition could result from lack of compound "D", if it is critical for some cellular function, or from toxicity due to excess "A", "B", and/or "C". Treatment of the metabolic disorder could be achieved through dietary supplementation of compound "D" and dietary restriction of compounds "A", "B", and/or "C" or by treatment with a medication that promoted disposal of excess "A", "B", or "C". Another approach that can be taken is enzyme replacement therapy, in which a patient is given an infusion of the missing enzyme.
Dietary restriction and supplementation are key measures taken in several well-known metabolic disorders, including galactosemia, phenylketonuria (PKU), maple syrup urine disease, organic acidurias and urea cycle disorders. Such restrictive diets can be difficult for the patient and family to maintain, and require close consultation with a nutritionist who has special experience in metabolic disorders. The composition of the diet will change depending on the caloric needs of the growing child and special attention is needed during a pregnancy if a woman is affected with one of these disorders.
Medical approaches include enhancement of residual enzyme activity (in cases where the enzyme is made but is not functioning properly), inhibition of other enzymes in the biochemical pathway to prevent buildup of a toxic compound, or diversion of a toxic compound to another form that can be excreted. Examples include the use of high doses of pyridoxine (vitamin B6) in some patients with homocystinuria to boost the activity of the residual cystathione synthase enzyme, administration of biotin to restore activity of several enzymes affected by deficiency of biotinidase, treatment with NTBC in Tyrosinemia to inhibit the production of succinylacetone which causes liver toxicity, and the use of sodium benzoate to decrease ammonia build-up in urea cycle disorders.
Certain lysosomal storage diseases are treated with infusions of a recombinant enzyme (produced in a laboratory), which can reduce the accumulation of the compounds in various tissues. Examples include Gaucher disease, Fabry disease, Mucopolysaccharidoses and Glycogen storage disease type II. Such treatments are limited by the ability of the enzyme to reach the affected areas (the blood brain barrier prevents enzyme from reaching the brain, for example), and can sometimes be associated with allergic reactions. The long-term clinical effectiveness of enzyme replacement therapies vary widely among different disorders.
There are a variety of career paths within the field of medical genetics, and naturally the training required for each area differs considerably. It should be noted that the information included in this section applies to the typical pathways in the United States and there may be differences in other countries. US Practitioners in clinical, counseling, or diagnostic subspecialties generally obtain board certification through the American Board of Medical Genetics.
Genetic information provides a unique type of knowledge about an individual and his/her family, fundamentally different from a typically laboratory test that provides a "snapshot" of an individual's health status. The unique status of genetic information and inherited disease has a number of ramifications with regard to ethical, legal, and societal concerns.
On 19 March 2015, scientists urged a worldwide ban on clinical use of methods, particularly the use of CRISPR and zinc finger, to edit the human genome in a way that can be inherited.[3][4][5][6] In April 2015 and April 2016, Chinese researchers reported results of basic research to edit the DNA of non-viable human embryos using CRISPR.[7][8][9] In February 2016, British scientists were given permission by regulators to genetically modify human embryos by using CRISPR and related techniques on condition that the embryos were destroyed within seven days.[10] In June 2016 the Dutch government was reported to be planning to follow suit with similar regulations which would specify a 14-day limit.[11]
The more empirical approach to human and medical genetics was formalized by the founding in 1948 of the American Society of Human Genetics. The Society first began annual meetings that year (1948) and its international counterpart, the International Congress of Human Genetics, has met every 5 years since its inception in 1956. The Society publishes the American Journal of Human Genetics on a monthly basis.
Medical genetics is now recognized as a distinct medical specialty in the U.S. with its own approved board (the American Board of Medical Genetics) and clinical specialty college (the American College of Medical Genetics). The College holds an annual scientific meeting, publishes a monthly journal, Genetics in Medicine, and issues position papers and clinical practice guidelines on a variety of topics relevant to human genetics.
The broad range of research in medical genetics reflects the overall scope of this field, including basic research on genetic inheritance and the human genome, mechanisms of genetic and metabolic disorders, translational research on new treatment modalities, and the impact of genetic testing
Basic research geneticists usually undertake research in universities, biotechnology firms and research institutes.
Sometimes the link between a disease and an unusual gene variant is more subtle. The genetic architecture of common diseases is an important factor in determining the extent to which patterns of genetic variation influence group differences in health outcomes.[12][13][14] According to the common disease/common variant hypothesis, common variants present in the ancestral population before the dispersal of modern humans from Africa play an important role in human diseases.[15] Genetic variants associated with Alzheimer disease, deep venous thrombosis, Crohn disease, and type 2 diabetes appear to adhere to this model.[16] However, the generality of the model has not yet been established and, in some cases, is in doubt.[13][17][18] Some diseases, such as many common cancers, appear not to be well described by the common disease/common variant model.[19]
Another possibility is that common diseases arise in part through the action of combinations of variants that are individually rare.[20][21] Most of the disease-associated alleles discovered to date have been rare, and rare variants are more likely than common variants to be differentially distributed among groups distinguished by ancestry.[19][22] However, groups could harbor different, though perhaps overlapping, sets of rare variants, which would reduce contrasts between groups in the incidence of the disease.
The number of variants contributing to a disease and the interactions among those variants also could influence the distribution of diseases among groups. The difficulty that has been encountered in finding contributory alleles for complex diseases and in replicating positive associations suggests that many complex diseases involve numerous variants rather than a moderate number of alleles, and the influence of any given variant may depend in critical ways on the genetic and environmental background.[17][23][24][25] If many alleles are required to increase susceptibility to a disease, the odds are low that the necessary combination of alleles would become concentrated in a particular group purely through drift.[26]
One area in which population categories can be important considerations in genetics research is in controlling for confounding between population substructure, environmental exposures, and health outcomes. Association studies can produce spurious results if cases and controls have differing allele frequencies for genes that are not related to the disease being studied,[27] although the magnitude of this problem in genetic association studies is subject to debate.[28][29] Various methods have been developed to detect and account for population substructure,[30][31] but these methods can be difficult to apply in practice.[32]
Population substructure also can be used to advantage in genetic association studies. For example, populations that represent recent mixtures of geographically separated ancestral groups can exhibit longer-range linkage disequilibrium between susceptibility alleles and genetic markers than is the case for other populations.[33][34][35][36] Genetic studies can use this admixture linkage disequilibrium to search for disease alleles with fewer markers than would be needed otherwise. Association studies also can take advantage of the contrasting experiences of racial or ethnic groups, including migrant groups, to search for interactions between particular alleles and environmental factors that might influence health.[37][38]
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Genetic Medicine | Department of Pediatrics | University …
Posted: at 6:56 am
Leadership
Michael Bamshad, MD Professor Division Chief
The Division of Genetic Medicine is committed to providing an outstanding level of patient care, education and research. The faculty have diverse interests and are drawn from several disciplines including clinical genetics, molecular genetics, biochemical genetics, human embryology/teratology and neurology.
A large clinical program of medical genetics operates from Seattle Childrens Hospital staffed by faculty from the Division. These clinical activities concentrate on pediatric genetics but also encompass adult and fetal consultations. At Seattle Children's full IP consultations are available and general genetics clinics occur regularly. Consultative services are also provided to the University of Washington Medical Center and Swedish Hospital. In addition, a variety of interdisciplinary clinical services are provided at Childrens including cardiovascular genetics, skeletal dysplasia, neurofibromatosis, craniofacial genetics, gender disorders, neurogenetics and biochemical genetics as well as others. A very large regional genetics service sponsored by state Departments of Health are provided to multiple outreach clinical sites in both Alaska and Washington.
Our research holds the promise for both continued development of improved molecular diagnostic tools and successful treatment of inherited diseases. Research in the Division is highly patient-driven. It often begins with a physician identifying a particular patients problems and subsequently taking that problem into a laboratory setting for further analysis. The Division has a strong research focus with established research programs in medical genetics information systems, neurogenetic disorders, fetal alcohol syndrome, neuromuscular diseases, human teratology, population genetics/evolution and gene therapy.
The Division offers comprehensive training for medical students, residents, and postdoctoral fellows in any of the areas of our clinical and research programs relevant to medical genetics. Medical Genetics Training Website
Margaret L.P. Adam, MD Associate Professor mpa5@u.washington.edu
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Jill Stein for President
Posted: at 6:55 am
Recently, our campaign received a letter that made our day.
Susan Sarandon wrote to us, and has now officially endorsed Jill!
Because she knows what you know - that we must build a progressive social movement to counter both Donald Trump AND Hillary Clinton.
According to The Young Turks and the Washington Times, Ms. Sarandon said:
Theyre both (Trump and Clinton) talking to Henry Kissinger. She did not learn from Iraq, and she is an interventionist, and she has done horrible things - and very callously. I dont know if she is overcompensating or what her trip is. That scares me. I think well be in Iran in two seconds.
And that is exactly what Jill Stein and Ajamu Baraka have been saying. And Dr. Cornel West. And Medea Benjamin. And Chris Hedges. And you. (Hey, you are in pretty good company).
Heres the letter from Ms. Sarandon to our campaign below.
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One week before whats shaping up to be an historic presidential election, Tavis Smiley on PBS will host a presidential forum featuring the third party candidates, Jill Stein of the Green Party and Gary Johnson of the Libertarian Party.
This forum will be taped live Monday, October 31, 2016, in the shows Los Angeles studio and air on Tavis Smiley over two nights next week on Monday evening and Tuesday, November 1 on PBS. An additional thirty (30) minute conversation, with questions selected entirely from social media will be available exclusively online at the Tavis Smiley PBS website.
Viewers may submit questions to the candidates via Twitter, Instagram and Facebook using the hashtags: #TavisSmileyForum, #AskJill or #AskGary.
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We offer the only alternative to a noxious buffoon on the one hand, and a representative of the corporate and military status quo on the other
Donald Trumps self-inflicted wounds and propensity for public meltdowns had pushed the public-opinion needle toward Hillary Clinton, according to recent polls. That may have changed a little in the aftermath of the FBIs renewing of its email probe last week. But even so, the fears of many voters that a Donald Trump presidency might become a reality have abated.
Those fears are not unfounded. Trumps failings as a candidate and a person are manifest, and he would be in a position to wreak considerable havoc if elected. Thats especially true at the agency level, with the judiciary and in other arenas where the president can wield executive power. The wildcard aspect of his personality poses risks that cant be predicted, nor can anyone know the degree to which congress would be inclined to obstruct or approve his most damaging initiatives.
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In 1854, a few thousand people gathered in Jackson, Michigan to launch an independent challenge to a national political system dominated by two parties. "Of strange, discordant, and even hostile elements," a party leader later recalled, "we gathered from the four winds[with] every external circumstance against us." This challenge was fueled by the radical abolitionist movement that united white workers and formerly enslaved Africans against the criminal institution of slavery, as a response to the political crisis caused by the Kansas-Nebraska Act.
In just two years, this insurgent third party created by movement activists had gained ground across the Northern states, challenging the Whig Party. In short order this insurgent "third party" had become a major opposition party. By 1858 they had won an influential foothold in Congress, and by 1860, that party leader Abraham Lincoln was elected President of the United States.
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Join with thousands of your neighbors to build the momentum for real change. Support Jill Stein's people-powered campaign today! Any amount you give will go to support the candidate who puts people, planet, and peace over profitevery time. DONATE
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Jill Stein for President
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