Daily Archives: June 17, 2016

Top Ten Cybernetic Upgrades Everyone Will Want

Posted: June 17, 2016 at 4:58 am

by Lifeboat Foundation Scientific Advisory Board member Michael Anissimov. Science fiction, computer games, anime cyborgs are everywhere. Transhumanists are philosophers who believe that one day, cybernetic upgrades will be so powerful, elegant, and inexpensive that everyone will want them. This report lists ten major upgrades that I think will be adopted by 2050. The List 10. Disease Immunity Between 20 and 40 years into the future, we will become capable of building artificial antibodies that outperform their natural equivalents. Instead of using chemical signaling that relies on diffusion to reach its target, these antibodies will communicate with rapid acoustic pulses. Instead of proteins, they will be made using much more durable polymers or even diamond. These antibodies will move through the bloodstream more quickly than other cells in the body, and will take up less space and resources, meaning that there will be room for many more. Using super-biological methods for identifying and neutralizing foreign viruses and bacteria, these tiny robots will still function in harmony with our own bodies. They will probably be powered either by glucose, ATP (like natural antibodies), or acoustically. There are already bloodborne microbots today which are not rejected by the immune system these are the precursors of tomorrows nanorobotics. Through their presence and continued operation, they will eliminate all susceptibility to disease in those who have them running through their veins. This will not make people immortal, but it will allow them to walk into a room contaminated with a flesh-eating virus in nothing but a pair of shorts and a T-shirt. For more on artificial antibodies and other body-integrated nanites, see Nanomedicine. 9. Telemicroscopic, Full-Spectrum Vision There are microscopes that weigh one tenth of an ounce. Some birds of prey have vision so sharp that they can spot a hare a mile away. We have compact devices that can scan the electromagnetic spectrum from x-rays to radio waves, and everything in between. Our eyes in their current form can do none of these things. But in time, they will be upgraded. There are already prosthetic retinas that can provide low-resolution artificial vision for blind people. Its simply a matter of time until better prosthetic eyes are created, and their sharpness, contrast, and resolution is superior to what evolution gave us. The biggest challenge may end up not actually being about building a superior artificial eye, but remodeling the visual cortex so that it can process the info and relay it to the rest of the brain in such a way that its not overwhelmed. 8. Telepathy/Brain-Computer Interfacing Ever wanted to send someone a message with nothing but your mind, or have a neural implant that gives your brain direct access to Google? Hundreds of corporate and academic labs across the world are working on projects that generate progress in this area. Check out the Berlin Brain-Computer Interface, which lets you move the cursor around on a screen with only your EEG waves and 20 minutes of training. Miniature fMRI will allow us to continue increasing the bandwidth between brain and computer, eventually allowing for a mental typewriter that converts thoughts into text. A tiny transmitter could send this to a bone-conduction device on the receiving person, letting them hear the message without sound. NASA is also working on a device to transcribe silent, subvocal speech. Like many transhumanist upgrades, these will probably start as efforts to help people who are handicapped, then evolve into powerful tools that can be used by anyone bold enough to adopt them. 7. Super-Strength Early in 2006, scientists at the University of Texas at Dallas, led by Dr. Ray H. Baughman, developed artificial muscles 100 times stronger than our own, powered by alcohol and hydrogen. Leonid Taranenko, the former Soviet weightlifter, holds the world record for power lifting a 266 kg (586 lbs) dumbbell. If Leos natural muscles were replaced with Dr. Baughmans synthetic polymer muscles, he could lift 26,600 kg, or about 30 tons. Thats equivalent to this yacht, the Nova Spirit. Super-strength is an interesting area in that the technology to do it has already been invented the only step remaining is actually weaving the fiber into a human body which, today, would be complicated and messy, not to mention probably illegal. However, that doesnt mean that it wont be done, probably within the next couple decades. Further improvements to the process could make it safe for normal people, numerous ethics questions notwithstanding. One benefit of improved muscles is that wed be far less vulnerable to unfortunate accidents. They could also provide armor against bullets or other forms of attack. One downside is that people could use them to bully others around. Guess the good guys will need even bigger muscles. 6. Improved Appearance In general, there is a lot of agreement as to who is attractive and who is less so. Numerous experiments have shown that while there are slight subjective differences in who we want to get with, we are biologically programmed to look for certain facial and physical features that correlate with increased fitness. For the time being, this is unavoidable. The only way to change it would be to reach inside our neural circuitry and start severing connections. Until we choose to do that, we can improve our own lives and the lives of those who have to look at us by looking as pretty or handsome as possible. We brush our teeth, keep fit, take showers, and all that other great stuff that helps us score. Some of us even visit the plastic surgeon, with mixed results. Surveys show that certain procedures, like liposuction, have very high patient satisfaction rates. As the safety and precision of our body modification technologies improves, well be able to change our faces and bodies with minimal fuss, and maximal benefit. Everyone will be able to be stunningly attractive. And the really great thing? Well always be able to enjoy it. If everyone becomes attractive, we wont regard the slightly less attractive of the lot as ugly our brain doesnt work that way. An attractive person is attractive, whether or not others are around. A planet full of attractive people could do a lot to improve our quality of life. 5. Psychokinesis In the real world, psychokinesis is a bunch of wishful thinking and pseudoscience. Despite the roughly 30% of people who think that its possible to affect objects through the mind alone, history and evidence make it clear that this is total nonsense. There are no psychics and there never have been. However, that doesnt mean that we cant create technopsychics artificially. By 2030, well be cranking out utility fog swarms of tiny machines that fly through the air and interlock with robotic arms. By combining brain-computer interfaces, like the type used by Claudia Mitchell to move her prosthetic arm, with utility fog, we will have direct-thought connections with powerful external robotics, allowing non-fictional psychokinesis. Utility fog, once all the necessary software for it is developed, will be capable of cooperating to perform practically any physical task or simulate a wide range of materials. Because utility fog could be distributed at low density and still accomplish a lot, a room filled with utility fog would look empty, and people in it could move and breathe normally. They would only notice once the fog is activated either by a central computer, or a neural interface. Once a connection is achieved, practically anything could be accomplished with the proper programming. Throwing objects through the air, hovering over the ground, cracking an egg from across the room, materializing orbs of energy all the antics weve always wanted to perform, but never had the means to. 4. Autopoiesi
s/Allopoiesis Autopoiesis is Greek for self-creation. Allopoiesis is other-creation. Our body engages in both all the time we start as a fetus that creates itself until it becomes an adult, then, essentially stops. Our body produces things external to itself, but usually involving an extended process of cooperation with thousands of other human beings and the entire economy. In the future, there will be cybernetic upgrades that allow for personal autopoietic and allopoietic manufacturing, probably based on molecular nanotechnology. Using whatever raw material is available, complex construction routines, and internal nanomanufacturing units, well be able to literally breathe life into dirt. If our arms or legs get blown off, well be able to use manufacturing modules in other parts of our body to regenerate them. Instead of building robots in a factory, well build them ourselves. The possibilities are quite expansive, but this would require technology more sophisticated than anything discussed thus far in this list. 3. Flight Human flight, outside of an airplane this was recently achieved by former military pilot Yves Rossy, who flew 7,750 ft above the Alps in his 10 ft wide, self-designed aerofoil. You can see a video of it here. The airfoil weighs only 110 lbs and cost just under $300,000. Over the next few decades, the weight will come down, the strength and flexibility will go up, and eventually it will be difficult to distinguish between people in aerofoils and people that can just fly whenever they want. Using high strength-to-weight materials like fullerenes, we will fly using wings that weigh only a fraction of our own weight and fold into our clothing or body when not in use. Rossy achieved speeds of 115 mph, but with superior materials and greater tolerance for acceleration and wind, our cybernetic flight speeds are more likely to top 500 mph. To take off from the ground, well simply use our super-muscles to jump to the highest object around and begin our flight from there. With personal flight, commercial airliners will become obsolete. The only problem left will be dodging each other. 2. Superintelligence When we think of superintelligence, we tend to think of the ways it is portrayed in fiction the character able to multiply 6 fifty digit numbers in his head, learn ten languages in a month, repeat the catch phrase Thats not logical, and other tired cliches. True superintelligence would be something radically different a person able to see the obvious solution that the entire human race missed, conceive of and implement advanced plans or concepts that the greatest geniuses would never think of, understand and rewrite its own cognitive processes on the most fundamental level, and so on. A cybernetic superintelligence would not just be another genius human, it would be something entirely superhuman something that could completely change the world overnight. For the same reason that we cant write a book with a character smarter than ourselves, we cant imagine the thoughts or actions of a true superintelligence, because theyd be beyond us. Whether it is developed through uploading, neuroengineering, or artificial intelligence, remains to be seen. 1. Immortality The ultimate upgrade would be physical immortality. Everything else pales by comparison. Today, there are already entire movements based around the idea. Realizing the possibility of immortality requires seeing a human being as a physical system composed of working parts that cooperate to make up the whole, some of which have the tendency to get old and break down. Cambridge biogerontologist Aubrey de Grey has identified seven causes of aging, which are believed to be comprehensive, because its been decades since a degenerative process has occurred in the body with an unknown cause. Defeating aging, then, would simply require addressing these one by one. They are: cell depletion, supernumerary cells, chromosomal mutations, mitochondrial mutations, cellular junk, extracellular junk, and protein cross-links. A few pioneering researchers are looking towards solutions, but accepting the possibility requires looking at aging as a disease and not as a necessary component of life. Well then, that just about wraps up our list. See you in 2050, alright?

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How to Use Psychedelics for a Healthy Mind and Direct …

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Psychedelic medicines are some of the most powerful tools in the world for personal healing and psychological growth. This guide is intended as a starting point for using psychedelics for personal healing, recovery, and development, on your own or with a mental health professional. This site is science-focused: at the bottom of each page, we link to articles and research studies related to the particular substance, treatment goal, and treatment method.

For an overview of recent research with mushrooms and LSD, take a look at Michael Pollan's wonderful 2015 New Yorker Cover Story, The Trip Treatment and the video Magic Mushrooms and the Healing Trip.

UPDATE: We are supporting the 920 Coalition's work to build a day of events around psychedelic mushroom research and awareness. Read more and join or participate in an event here.

All of our guides are listed on the left sidebar. Some of our most popular are:

Treating Depression >> Treating Anxiety >> Mushroom Guide >>

Research at major medical centers over the past few years have shown remarkable results in the treatment of conditions such as depression, post-traumatic stress disorder (PTSD), and anxiety. The same protocols used in these research settings can be done at home or with an independent practitioner and frequently lead to new insights and dramatic breakthroughs in mental health. This site is designed to help you do that.

Psychedelic medicines provide a path of treatment that is often more effective and rapid than other methods, and with many fewer side effects than pharmaceutical options. In addition, psychedelics have been effective for patients who have not made progress with other approaches.

Several organizations are working with and funding research at major medical centers around the world to expand the use of these drugs for therapeutic purposes. More than 50% of Americans support legalization of marijuana and that number is rising every year. Over 75% now support medical marijuana access. Recently, several countries and many US states have authorized use of marijuana for medical and personal purposes and other psychedelics are moving quickly towards approval as prescription medicine. See our resources page to learn more.

Psychedelics have also been shown to reliably and predictably provide powerful spiritual and religious experiences and to create lasting positive personality changes, increasing emotional openness and acceptance of difficult experiences. In a recent Johns Hopkins research study that administered psilocybin mushrooms, "94 percent of subjects said that it was one of the five most meaningful experiences of their lives; 39 percent said that it was the most meaningful experience" (New York Times).

Unless you know a lot about psychedelics, you probably have mostly inaccurate information floating around in your head. We certainly did, until we started reading and having our own experiences. But times are changing very fast and the conversation is quickly moving back to reality-- new research on psychedelics is accelerating at major universities and legalization of marijuana is now supported by the majority of the population.

Even a cursory review of the research shows that psychedelics are dramatically safer and have far fewer side effects than alcohol, cigarettes, narcotics, and most pharmaceutical anti-depressants (please, read the research!). Yet marijuana, mushrooms, LSD, MDMA, and other substances have been lumped into the futile war on drugs and now two generations have grown up with a completely distorted understanding of what should be understood as medicines.

We are a group of friends, professionals in our late 20s and 30s-- theres a lawyer, a mobile game company CEO, a television producer, a non-profit director, a reporter, and a filmmaker. Half female and half male. White, black, and asian. Psychedelics have helped to open us emotionally, relieve stress, depression, and trauma, connect more deeply to our creative core, and have given us powerful spiritual experiences that weve never had before.

All of us have been both surprised and amazed over the past few years as psychedelic experiences have become an important part of our lives and of the people around us.

We were surprised because these incredible tools have been so overlooked and misunderstood that we could have gone through our whole lives without having seriously explored them. Its actually a little bit scary to think how easily that could have happened and how much we would have missed out on. We feel very lucky.

And we are amazed at the extent of the positive impact on our lives and our work, and the incredible freedom that weve felt in the experiences and afterwards. We want to share this.

When used intelligently, in positive environments, and with purpose, psychedelics bring love, energy, creativity, and healing to individuals and to society.

Canadian psychiatrist Dr. Humphry Osmond coined the word 'psychedelic', a combination of the Greek words for 'mind' and 'make visible, reveal'. We hope to bring some clarity to the subject of psychedelics, which in turn bring clarity about our own minds.

Weve created this site because, despite all the information available about psychedelics, we havent found a clear, simple, and up-to-date guide thats grounded in science. You can help us change how the world sees psychedelics by sharing this guide with your friends and helping to create positive environments for them to make psychedelics a healthy part of their life.

To be clear, psychedelics are very powerful medicines and they have risks. Like almost everything that gets ingested in our society, they can be misused and are very misunderstood. Even many intelligent people who used psychedelics repeatedly in their youth did so in a party setting and have never experienced the psychological and spiritual benefits that emerge in an intentional session. The difference is dramatic.

We cant recommend that anyone use psychedelics and we urge you to be extremely careful about the dose and quality of the substance, setting of use, the age of the individual and their mental state, and potential supplement and drug interactions. Prohibition of these substances in many locations has made it more difficult to create a safe environment, but doing so is essential.

And please be in touch and let us know what could be better-- we will be making updates and adding new research frequently.

Psychedelics have been misunderstood and misrepresented for decades. That's changing. Please help us share safe, responsible information on using psychedelics by sending this page to friends, and posting to Facebook, Twitter, and Google:

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FS Book Co – Marijuana Books

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Stairway to Heaven: Psychedelics Soothe Dying – ABC News

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For the last eight years, Nicky has struggled with advanced ovarian cancer, and despite repeated rounds of chemotherapy and radiation, it's unclear how long she has to live.

"Ovarian cancer has a very bleak outlook -- less than 30 percent make it to five years," said the 67-year-old former New York City French teacher. "I was diagnosed in 2002, and I was going in to my fourth year and had a recurrence -- which was like the proverbial shoe dropping -- and it frightened me so much."

"For the moment, there is no pain," she said. "The most difficult part is leaving this world early. I wasn't ready to get on that bus."

But last May, Nicky volunteered to take a psychedelic "trip" on psilocybin -- the hallucinogenic compound from "magic mushrooms" -- which has been used for thousands of years by indigenous cultures to reach higher levels of spirituality and consciousness.

Today, even after losing seven friends from her cancer support group in 15 months, Nicky said she is less afraid of death and is living her life more "honestly and authentically."

Nicky was one of the first terminally ill participants in an ongoing study at New York University on the use of hallucinogens to help those with terminal illnesses.

"I had a wonderful life, a fabulous child and beautiful grandchildren, and here my life was cut short," she said. "I thought of my two granddaughters and not seeing them growing up and graduating from college -- it made me profoundly sad. I wanted to do something for myself, to be able to live more in the moment, rather than worrying about the future and having all these existential thoughts about what life was all about."

Her "trip" took place under full medical supervision in a warm, living room-like setting with art books, fresh fruit, flowers and soothing music. She was given a pill in an earthenware chalice and a single rose, then hunkered down on a cozy sofa with eyeshades and headphones.

"I was in a dome and it was all bejeweled with colors, mostly striped, like a kaleidoscope, but not turning," she said. "Every once in awhile, the dome would open up at the top and send a luminescence," she said. "I was in awe and could feel myself taking deep breaths. At the same, tears were running down my face, but I was not crying."

"It was incredible," she said. "I wanted to share it. I couldn't believe the world could be so beautiful."

Researchers at New York University say that in a controlled setting, hallucinogens, which alter perception and cognition, can help patients reduce the anxiety, personal isolation and fear of death.

"I am still not ready to die," said Nicky, who just returned from trips to Mexico and Bali and boxes with a trainer several times a week. "It's definitely improved my interactions with those closest to me and figuring out how I want to live my life."

"Has my anxiety of dying gone away? I would say no, I don't ever want to die. Will I be able to walk toward death with a little less fear? Perhaps," she said. "I know it sounds trite, but I live more in the moment," she said.

The three-year study, "Effects of Psilocybin on Anxiety and Psychosocial Distress in Advanced Cancer Patients," is being privately funded by the Zurich-based Heffter Research Institute , which promotes the use of psychedelics for the alleviation of suffering. Fully approved by the Food and Drug Administration (FDA), it adheres to rigorous safety guidelines and protocols.

Researchers hope that it will one day lead to reclassification of Schedule 1 hallucinogens so that doctors may prescribe them to patients for palliative care, depression and even addiction.

"It's daunting working with people in the midst of death," said principal investigator Dr. Stephen Ross, assistant professor of psychiatry and director of the NYU Langone Center of Excellence on Addiction. "To help people to have a good death, and not more chemotherapy, to prepare for the final part of life and to die with dignity and do it in a way that they are not frightened, that is one of the most important endeavors as a physician."

Ross and his colleagues are looking for 32 patients who are willing to participate in the random, double-blind study. To be eligible, patients must be 18 to 76 years old with the diagnosis of a "potentially life-threatening disease" or advanced or recurrent cancer who are displaying symptoms of acute stress, anxiety or adjustment disorder due to their disease.

Patients are screened carefully -- those with psychotic spectrum disorders, such as schizophrenia, bipolar disorder and severe depression cannot participate.

"Mysticism is really the cornerstone of all major religions going back millennia," said co-principal investigator Anthony Bossis , professor of psychiatry and anesthesiology at the NYU School of Medicine.

"It is characterized by a sense of unity, transcendence, connecting to the broader universe and a sense of life and the promotion of personal spirituality," he said. "It recalibrates how we see our life and gives a sense of sacredness and reshapes how we view death."

A mystical experience can help root patients like Nicky more in the present, according to Bossis. "People with cancer can spend their final days and months not anxious and improvement in quality of life is attainable," he said. "These experiences have the potential to do that."

Scientists across the country have shown a renewed interest in the medical uses of hallucinogens. So far, 80 to 90 patients have had similar experiences in studies on psilocybin at other universities including Johns Hopkins and UCLA.

In a study on 36 patients at Johns Hopkins, researchers looked at the effects of psilocybin on depression. At the 14-month follow-up, more than 60 percent of volunteers rated the experience as among the five most meaningful and spiritually significant of their lives; 58 percent reported a "complete" mystical experience.

"We have come a long way in pain management with the use of opiods , but the sheer anxiety is so hard to address in a medical setting," said Bossis, a clinical psychologist whose specialty is end-of-life care.

"The heart of this study is to address these levels of suffering and get at the existential [fear] of not being here any longer that we all face," he said. "We provide an empirical experience where the patient goes into a journey -- his own journey -- and can find resolution and peace and transformation and return back here to integrate it into their lives."

Psilocybin, an alkaloid compound in the tryptamine family, is produced by hundreds of species of fungi and acts on the serotonin receptors in the part of the brain responsible for non-verbal imagery and emotion. Its mind-altering effects can last anywhere from three to eight hours.

It is in the same class of chemicals as mescaline, contained in the peyote cactus, which is used in religious ceremonies by Native Americans, and dimethyltryptamine, which is in ayahuasca, used by indigenous South American religions. The effects are sometimes described as similar to near-death experiences. Some research has shown that brain activity under psilocybin mimics closely that of Buddhist monks meditating.

"It appears we are hardwired with neuro-circuitry to meditate and have the spiritual experience," said Ross.

Psychologist Timothy Leary popularized hallucinogens like LSD in his 1964 book with Ralph Metzner, "The Psychedelic Experience," which he hailed as a way to "journey into new realms of consciousness."

"It opens the
mind, frees the nervous system of it ordinary patterns and structures," Leary wrote.

Experiments with LSD took place as early as the late 1940s and 1950s, after it was discovered in an ergot fungus by Swiss chemist Dr. Albert Hoffman.

By 1965, more than 2,000 papers had described positive results in 40,000 patients with few side effects and a high level of safety in the treatment of psychiatric orders, depression, sexual dysfunction, bereavement and even addiction, according to the British Journal of Psychiatry.

But by 1966, the drug was made illegal after abuses by the hippie counterculture, scientists distanced themselves and the government cracked down on research licenses. By the 1970s, under pressure from the U.S. Justice Department, virtually all research ended.

"It got demonized as a most addictive drug, but the irony is that it is not addictive," said Ross. "Used in the models we describe, it can actually lead to sustained sobriety."

Volunteers in the NYU study agree to take part in two full-day sessions, seven weeks apart, where they are administered either a placebo or the psilocybin. They are monitored for anxiety and outcomes two to four weeks prior to drug administration, then one day prior, then again seven hours, one day and several weeks' intervals until 26 weeks post administration.

Investigators also measure depression, pain and quality of life as well as attitude toward their disease progression at designated intervals.

Beforehand, they undergo preparation for the experience in psychotherapy. "We take their life narrative and their cancer narrative and review all the safety parameters -- what happens if X," said Ross.

When the drug is administered, the patient is paired with a male and female therapist to monitor responses and for comfort.

"Emotional stability optimizes the chance for a good experience," said Bossis. "Trust with the monitors is crucial . If the patient doesn't feel safe, we don't go forward."

Sometimes the experience is traumatizing, but facing fears is part of the process. Doctors have an antidote to abort the experience, if necessary, or use valium to calm a patient down.

"We encourage them to go inward, to minimize the communication with us and enter the experience, even if it's something dark and difficult that comes before them," said Bossis. "We tell patients that no matter where they find themselves, they will return to a normal state of consciousness within six hours."

Two of the three patients in Nicky's group have already died. Both reported extraordinary experiences -- "a cleansing of the body and soul of grief and sadness and an increase in the acceptance of the disease and the dying process," according to Bossis.

The patients said they wanted to give back more -- financially or emotionally and were able to reconnect with estranged friends and family members. Both were "peaceful and thankful," at the end, he said.

As for Nicky, the first hour of her psychedelic journey was awe-inspiring, but the second part was deeper and more emotional. At several points, she had to sit up and take off her eyeshades and seek the comfort of Ross and her other therapist.

"I became profoundly sad, and I actually had to sit up after 45 minutes and talk to them and I cried a lot," she said. "There was another scenario, then I went through the rest by myself."

In six hours, when it was all over, she stayed and analyzed her experience with the doctors.

"In therapy we had been working on my top five [issues with death or family]," she said. "During my experience, I reordered the hierarchy of issues to lead a more authentic life emotionally. I didn't realize my number four was actually number one."

"It was such an enormous gift," said Nicky. "It's really amazing that a king's ransom arrived at my door step."

Today, Nicky said she would take psilocybin again -- "in a New York minute." She continues her therapy at NYU and will go on a drug trial soon for late-stage ovarian cancer. She also hopes that her openness about the psychedelic experience will help others.

"I don't think people should be so afraid of something that could be so helpful when you are nearing the end of life," she said. "I had huge insight into my head. I can still conjure it up and I tried for very long to relive it -- it was breathtaking."

Nicky never expected to find God. "I didn't have that spiritual experience, but my dome was very close," she said. "When it opened up several times and let in the light, I would have thought it was my creator if I had been religious."

For more information on how to participate in the study, contact patient coordinator Krystallia Kalliontzi at 212-998-9252 or kk71@nyu.edu.

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Entheogen – Wikipedia, the free encyclopedia

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An entheogen ("generating the divine within")[4] is any chemical substance used in a religious, shamanic, or spiritual context[5] that often induces psychological or physiological changes.

Entheogens have been used to supplement many diverse practices geared towards achieving transcendence, including meditation, yoga, prayer, psychedelic art, chanting, and multiple forms of music. They have also been historically employed in traditional medicine via psychedelic therapy.

Entheogens have been used in a ritualized context for thousands of years; their religious significance is well established in anthropological and modern contexts. Examples of traditional entheogens include traditional psychedelics like peyote, psilocybin mushrooms, and ayahuasca, psychedelic-dissociatives like Tabernanthe iboga, atypical psychedelics like Salvia divinorum, quasi-psychedelics like cannabis, and deliriants like Amanita muscaria. Traditionally a tea, admixture, or potion like bhang is the preferred mode of ingestion.

With the advent of organic chemistry, there now exist many synthetic drugs with similar psychoactive properties, many derived from the aforementioned plants. Many pure active compounds with psychoactive properties have been isolated from these respective organisms and chemically synthesized, including mescaline, psilocybin, DMT, salvinorin A, ibogaine, ergine, and muscimol. Semi-synthetic (e.g., LSD used by the Neo-American Church) and synthetic drugs (e.g., DPT used by the Temple of the True Inner Light and 2C-B used by the Sangoma) have also been developed.[6] Cannabis is the world's most widely used psychedelic drug, though it is more accurately referred to as a quasi-psychedelic drug, since its effect profile lacks the hallucinogenic and cognitive effects of traditional psychedelics.

More broadly, the term entheogen is used to refer to any psychoactive drugs when used for their religious or spiritual effects, whether or not in a formal religious or traditional structure. This terminology is often chosen to contrast with recreational use of the same drugs. Studies such as Timothy Leary's Marsh Chapel Experiment and Roland Griffiths' psilocybin studies at Johns Hopkins have documented reports of mystical/spiritual/religious experiences from participants who were administered psychoactive drugs in controlled trials. Ongoing research is limited due to widespread drug prohibition; however, some countries have legislation that allows for traditional entheogen use.

The neologism entheogen was coined in 1979 by a group of ethnobotanists and scholars of mythology (Carl A. P. Ruck, Jeremy Bigwood, Danny Staples, Richard Evans Schultes, Jonathan Ott and R. Gordon Wasson). The term is derived from two words of ancient Greek, (entheos) and (genesthai). The adjective entheos translates to English as "full of the god, inspired, possessed", and is the root of the English word "enthusiasm." The Greeks used it as a term of praise for poets and other artists. Genesthai means "to come into being." Thus, an entheogen is a drug that causes one to become inspired or to experience feelings of inspiration, often in a religious or "spiritual" manner.[7]

Entheogen was coined as a replacement for the terms hallucinogen and psychedelic. Hallucinogen was popularized by Aldous Huxley's experiences with mescaline, which were published as The Doors of Perception in 1954. Psychedelic, in contrast, is a Greek neologism for "mind manifest", and was coined by psychiatrist Humphry Osmond; Huxley was a volunteer in experiments Osmond was conducting on mescaline.

Ruck et al. argued that the term hallucinogen was inappropriate owing to its etymological relationship to words relating to delirium and insanity. The term psychedelic was also seen as problematic, owing to the similarity in sound to words pertaining to psychosis and also due to the fact that it had become irreversibly associated with various connotations of 1960s pop culture. In modern usage entheogen may be used synonymously with these terms, or it may be chosen to contrast with recreational use of the same drugs. The meanings of the term entheogen were formally defined by Ruck et al.:

In a strict sense, only those vision-producing drugs that can be shown to have figured in shamanic or religious rites would be designated entheogens, but in a looser sense, the term could also be applied to other drugs, both natural and artificial, that induce alterations of consciousness similar to those documented for ritual ingestion of traditional entheogens.

In essence, all psychoactive drugs that are biosynthesized in nature by cytota (cellular life), can be used in an entheogenic context or with entheogenic intent. To exclude non-psychoactive drugs that sometimes also are used in spiritual context, the term "entheogen" refers primarily to drugs that have been categorized based on their historical use. Toxicity does not affect a drug's inclusion (some can kill humans), nor does effectiveness or potency (if a drug is psychoactive, and it has been used in a historical context, then the required dose has also been found).

High caffeine consumption has been linked to an increase in the likelihood of experiencing auditory hallucinations. A study conducted by the La Trobe University School of Psychological Sciences revealed that as few as five cups of coffee a day could trigger the phenomenon.[9]

Many man-made chemicals with little human history have been recognized to catalyze intense spiritual experiences, and many synthetic entheogens are simply slight modifications of their naturally occurring counterparts. Some synthetic entheogens like 4-AcO-DMT are theorized to be prodrugs that metabolize into the natural psychoactive, similar in nature to how the synthetic compound heroin is deacetylated by esterase to the active morphine. While synthesized DMT and mescaline is reported to have identical entheogenic qualities as extracted or plant based sources, the experience may wildly vary due to the lack of numerous psychoactive alkaloids that constitute the material. This is similar to how pure THC is very different than an extract that retains the many cannabinoids of the plant such as cannabidiol and cannabinol.

Yohimbine is an alkaloid naturally found in Pausinystalia yohimbe (Yohimbe), Rauwolfia serpentina (Indian Snakeroot), and Alchornea floribunda (Niando), along with several other active alkaloids. There are no references to these species in traditional use to induce past memories, most likely because their alkaloid content is too low; However, laboratory extracted yohimbine, now commonly sold as sport supplement, may be used in psychedelic therapy to facilitate recall of traumatic memories in the treatment of post traumatic stress disorder (PTSD).[16]

L. E. Hollister's criteria for establishing that a drug is hallucinogenic is:[17]

Most NMDA-antagonist dissociative drugs including ketamine, PCP, and DXM are drugs known to easily cause clinical psychological dependence, but also strengthen narcissism, and induces chemical dependence, and NMDA receptor antagonist neurotoxicity (NAN), when used chronically.

Common recreational drugs that cause chemical dependence have a history of entheogenic use. Perhaps because they could not access traditional entheogens as shamans were very secret with their sacraments who regarded non-visioning sacraments as hedonistic. The drugs mentioned here have occasionally been used by some sh
amans but they are psychoactive drugs that are not classified as hallucinogens (psychedelic, dissociative or deliriant). These drugs are not researched chemicals for psychedelic therapy as they have low therapeutic index.

This means that chewing the leaves or drinking coca tea does not produce the intense high (euphoria, megalomania, depression) people experience with cocaine. However, even if it would produce such effect, the next problem would be cocaine dependence.

Drugs, including some that cause physical dependence, have been used with entheogenic intention, mostly in ancient times.

Alcohol has sometimes been invested with religious significance.

The present day Arabic word for alcohol appears in The Qur'an (in verse 37:47) as al-awl, properly meaning "spirit" or "demon", in the sense of "the thing that gives the wine its headiness."[citation needed] The term ethanol was invented 1838, modeled on German thyl (Liebig), from Greek aither (see ether), and hyle "stuff". Ether in late 14c. meant "upper regions of space," from Old French ether and directly from Latin aether, "the upper pure, bright air," from Greek aither "upper air; bright, purer air; the sky," from aithein "to burn, shine," from PIE root *aidh- "to burn" (see edifice).[23]

In ancient Celtic religion, Sucellus or Sucellos was the god of agriculture, forests and alcoholic drinks of the Gauls.

Ninkasi is the ancient Sumerian tutelary goddess of beer.[24]

In the ancient Greco-Roman religion, Dionysos (or Bacchus) was the god of the grape harvest, winemaking and wine, of ritual madness and ecstasy, of merry making and theatre. The original rite of Dionysus is associated with a wine cult and he may have been worshipped as early as c. 15001100 BC by Mycenean Greeks. The Dionysian Mysteries were a ritual of ancient Greece and Rome which used intoxicants and other trance-inducing techniques (like dance and music) to remove inhibitions and social constraints, liberating the individual to return to a natural state. In his Laws, Plato said that alcoholic drinking parties should be the basis of any educational system, because the alcohol allows relaxation of otherwise fixed views. The Symposium (literally, 'drinking together') was a dramatised account of a drinking party where the participants debated the nature of love.

In the Homeric Hymn to Demeter, a cup of wine is offered to Demeter which she refuses, instead insisting upon a potion of barley, water, and glechon, known as the ceremonial drink Kykeon, an essential part of the Mysteries. The potion has been hypothesized to be an ergot derivative from barley, similar to LSD.[25]

Egyptian pictographs clearly show wine as a finished product around 4000 BC. Osiris, the god who invented beer and brewing, was worshiped throughout the country. The ancient Egyptians made at least 24 types of wine and 17 types of beer. These beverages were used for pleasure, nutrition, rituals, medicine, and payments. They were also stored in the tombs of the deceased for use in the afterlife.[26] The Osirian Mysteries paralleled the Dionysian, according to contemporary Greek and Egyptian observers. Spirit possession involved liberation from civilization's rules and constraints. It celebrated that which was outside civilized society and a return to the source of being, which would later assume mystical overtones. It also involved escape from the socialized personality and ego into an ecstatic, deified state or the primal herd (sometimes both).

Some scholars[who?] have postulated that pagan religions actively promoted alcohol and drunkenness as a means of fostering fertility. Alcohol was believed to increase sexual desire and make it easier to approach another person for sex. For example, Norse paganism considered alcohol to be the sap of Yggdrasil. Drunkenness was an important fertility rite in this religion.

Many Christian denominations use wine in the Eucharist or Communion and permit alcohol consumption in moderation. Other denominations use unfermented grape juice in Communion; they either voluntarily abstain from alcohol or prohibit it outright.

Judaism uses wine on Shabbat and some holidays for Kiddush as well as more extensively in the Passover ceremony and other religious ceremonies. The secular consumption of alcohol is allowed. Some Jewish texts, e.g., the Talmud, encourage moderate drinking on holidays (such as Purim) in order to make the occasion more joyous.

Kava cultures are the religious and cultural traditions of western Oceania which consume kava. There are similarities in the use of kava between the different cultures, but each one also has its own traditions.

Entheogens have been used by individuals to pursue spiritual goals such as divination, ego death, egolessness, faith healing, psychedelic therapy and spiritual formation.[27]

There are also instances where people have been given entheogens without their knowledge or consent (e.g., tourists in Ayahuasca),[28] as well as attempts to use such drugs in other contexts, such as cursing, psychochemical weaponry, psychological torture, brainwashing and mind control; CIA experiments with LSD were used in Project MKUltra, and controversial entheogens like alcohol are often mentioned in context of bread and circuses.

Entheogens have been used in various ways, e.g., as part of established religious rituals, as aids for personal spiritual development ("plant teachers"),[29][30] as recreational drugs, and for medical and therapeutic use. The use of entheogens in human cultures is nearly ubiquitous throughout recorded history.

Naturally occurring entheogens such as psilocybin and DMT (in the preparation ayahuasca), were, for the most part, discovered and used by older cultures, as part of their spiritual and religious life, as plants and agents that were respected, or in some cases revered for generations and may be a tradition that predates all modern religions as a sort of proto-religious rite.

One of the most widely used entheogens is cannabis, entheogenic use of cannabis has been used in regions such as China, Europe, and India, and, in some cases, for thousands of years. It has also appeared as a part of religions and cultures such as the Rastafari movement, the Sadhus of Hinduism, the Scythians, Sufi Islam, and others.

The best-known entheogen-using culture of Africa is the Bwitists, who used a preparation of the root bark of Tabernanthe iboga.[31] Although the ancient Egyptians may have been using the sacred blue lily plant in some of their religious rituals or just symbolically, it has been suggested that Egyptian religion once revolved around the ritualistic ingestion of the far more psychoactive Psilocybe cubensis mushroom, and that the Egyptian White Crown, Triple Crown, and Atef Crown were evidently designed to represent pin-stages of this mushroom.[32] There is also evidence for the use of psilocybin mushrooms in Ivory Coast.[33] Numerous other plants used in shamanic ritual in Africa, such as Silene capensis sacred to the Xhosa, are yet to be investigated by western science. A recent revitalization has occurred in the study of southern African psychoactives and entheogens (Mitchell and Hudson 2004; Sobiecki 2002, 2008, 2012).[34]

Entheogens have played a pivotal role in the spiritual practices of most American cultures for millennia. The first American entheogen to be subject to scientific analysis was the peyote cactus (Lophophora williamsii). For his part, one of the founders of modern ethno-botany, the late-Richard Evans
Schultes of Harvard University documented the ritual use of peyote cactus among the Kiowa, who live in what became Oklahoma. While it was used traditionally by many cultures of what is now Mexico, in the 19th century its use spread throughout North America, replacing the deadly toxic mescal bean (Calia secundiflora) who are questioned to be an entheogen at all. Other well-known entheogens used by Mexican cultures include the alcoholic Aztec sacrament, pulque, ritual tobacco (known as 'picietl' to the Aztecs, and 'sikar' to the Maya (from where the word 'cigar' derives), psilocybin mushrooms, morning glories (Ipomoea tricolor and Turbina corymbosa), and Salvia divinorum.

Indigenous peoples of South America employ a wide variety of entheogens. Better-known examples include ayahuasca (most commonly Banisteriopsis caapi and Psychotria viridis) among indigenous peoples (such as the Urarina) of Peruvian Amazonia. Other entheogens include San Pedro cactus (Echinopsis pachanoi, syn. Trichocereus pachanoi), Peruvian torch cactus (Echinopsis peruviana, syn. Trichocereus peruvianus), and various DMT-snuffs, such as epen (Virola spp.), vilca and yopo (Anadenanthera colubrina and A. peregrina, respectively). The familiar tobacco plant, when used uncured in large doses in shamanic contexts, also serves as an entheogen in South America. Also, a tobacco that contains higher nicotine content, and therefore smaller doses required, called Nicotiana rustica was commonly used.[citation needed]

Entheogens also play an important role in contemporary religious movements such as the Rastafari movement and the Church of the Universe.

Datura wrightii is sacred to some Native Americans and has been used in ceremonies and rites of passage by Chumash, Tongva, and others. Among the Chumash, when a boy was 8 years old, his mother would give him a preparation of momoy to drink. This supposed spiritual challenge should help the boy develop the spiritual wellbeing that is required to become a man. Not all of the boys undergoing this ritual survived.[35]Momoy was also used to enhance spiritual wellbeing among adults . For instance, during a frightening situation, such as when seeing a coyote walk like a man, a leaf of momoy was sucked to help keep the soul in the body.

The indigenous peoples of Siberia (from whom the term shaman was borrowed) have used Amanita muscaria as an entheogen.

In Hinduism, Datura stramonium and cannabis have been used in religious ceremonies, although the religious use of datura is not very common, as the primary alkaloids are strong deliriants, which causes serious intoxication with unpredictable effects.

Also, the ancient drink Soma, mentioned often in the Vedas, appears to be consistent with the effects of an entheogen. In his 1967 book, Wasson argues that Soma was Amanita muscaria. The active ingredient of Soma is presumed by some to be ephedrine, an alkaloid with stimulant and (somewhat debatable)[by whom?] entheogenic properties derived from the soma plant, identified as Ephedra pachyclada. However, there are also arguments to suggest that Soma could have also been Syrian rue, cannabis, Atropa belladonna, or some combination of any of the above plants.[citation needed]

Fermented honey, known in Northern Europe as mead, was an early entheogen in Aegean civilization, predating the introduction of wine, which was the more familiar entheogen of the reborn Dionysus and the maenads. Its religious uses in the Aegean world are bound up with the mythology of the bee.

Dacians were known to use cannabis in their religious and important life ceremonies, proven by discoveries of large clay pots with burnt cannabis seeds in ancient tombs and religious shrines. Also, local oral folklore and myths tell of ancient priests that dreamed with gods and walked in the smoke. Their names, as transmitted by Herodotus, were "kap-no-batai" which in Dacian was supposed to mean "the ones that walk in the clouds".

The growth of Roman Christianity also saw the end of the two-thousand-year-old tradition of the Eleusinian Mysteries, the initiation ceremony for the cult of Demeter and Persephone involving the use of a drug known as kykeon. The term 'ambrosia' is used in Greek mythology in a way that is remarkably similar to the Soma of the Hindus as well.

A theory that natural occurring gases like ethylene used by inhalation may have played a role in divinatory ceremonies at Delphi in Classical Greece received popular press attention in the early 2000s, yet has not been conclusively proven.[36]

Mushroom consumption is part of the culture of Europeans in general, with particular importance to Slavic and Baltic peoples. Some academics consider that using psilocybin- and or muscimol-containing mushrooms was an integral part of the ancient culture of the Rus' people.[37]

It has been suggested that the ritual use of small amounts of Syrian rue is an artifact of its ancient use in higher doses as an entheogen (possibly in conjunction with DMT containing acacia).[citation needed]

Philologist John Marco Allegro has argued in his book The Sacred Mushroom and the Cross that early Jewish and Christian cultic practice was based on the use of Amanita muscaria, which was later forgotten by its adherents. Allegro's hypothesis is that Amanita use was sacred knowledge kept only by high figures to hide the true beginnings of the Christian cult, seems supported by his own view that the Plaincourault Chapel shows evidence of Christian amanita use in the 13th century.[38]

In general, indigenous Australians are thought not to have used entheogens, although there is a strong barrier of secrecy surrounding Aboriginal shamanism, which has likely limited what has been told to outsiders. A plant that the Australian Aboriginals used to ingest is called Pitcheri, which is said to have a similar effect to that of coca. Pitcheri was made from the bark of the shrub Duboisia myoporoides. This plant is now grown commercially and is processed to manufacture an eye medication. There are no known uses of entheogens by the Mori of New Zealand aside from a variant species of kava.[39] Natives of Papua New Guinea are known to use several species of entheogenic mushrooms (Psilocybe spp, Boletus manicus).[40]

Kava or kava kava (Piper Methysticum) has been cultivated for at least 3000 years by a number of Pacific island-dwelling peoples. Historically, most Polynesian, many Melanesian, and some Micronesian cultures have ingested the psychoactive pulverized root, typically taking it mixed with water. Much traditional usage of kava, though somewhat suppressed by Christian missionaries in the 19th and 20th centuries, is thought to facilitate contact with the spirits of the dead, especially relatives and ancestors.[41]

Some religions forbid, discourage, or restrict the drinking of alcoholic beverages. These include Islam, Jainism, the Bah' Faith, The Church of Jesus Christ of Latter-day Saints (LDS Church), the Seventh-day Adventist Church, the Church of Christ, Scientist, the United Pentecostal Church International, Theravada, most Mahayana schools of Buddhism, some Protestant denominations of Christianity, some sects of Taoism (Five Precepts and Ten Precepts), and Hinduism.

The Pali Canon, the scripture of Theravada Buddhism, depicts refraining from alcohol as essential to moral conduct because intoxication causes a loss of mindfulness. The fifth of the Five Precepts states, "Sur-meraya-majja-pamdahn verama sikkhpada samdiymi." In English: "I undertake to refrain from fermented drink that causes heedlessness." Technically, th
is prohibition does not include other mind-altering drugs. The canon does not suggest that alcohol is evil but believes that the carelessness produced by intoxication creates bad karma. Therefore, any drug (beyond tea or mild coffee) that affects one's mindfulness be considered by some to be covered by this prohibition.[citation needed]

Many Christian denominations disapprove of the use of most illicit drugs. The early history of the Church, however, was filled with a variety of drug use, recreational and otherwise.[42]

The primary advocate of a religious use of cannabis plant in early Judaism was Sula Benet, also called Sara Benetowa, a Polish anthropologist, who claimed in 1967 that the plant kaneh bosm - mentioned five times in the Hebrew Bible, and used in the holy anointing oil of the Book of Exodus, was in fact cannabis.[43] The Ethiopian Zion Coptic Church confirmed it as a possible valid interpretation.[44] The lexicons of Hebrew and dictionaries of plants of the Bible such as by Michael Zohary (1985), Hans Arne Jensen (2004) and James A. Duke (2010) and others identify the plant in question as either Acorus calamus or Cymbopogon citratus.[45] Kaneh-bosm is listed as an incense in the Old Testament. It is generally held by academics specializing in the archaeology and paleobotany of Ancient Israel, and those specializing in the lexicography of the Hebrew Bible that cannabis is not documented or mentioned in early Judaism. Against this some popular writers have argued that there is evidence for religious use of cannabis in the Hebrew Bible,[46] although this hypothesis and some of the specific case studies (e.g., John Allegro in relation to Qumran, 1970) have been "widely dismissed as erroneous, others continue".[47]

According to The Living Torah, cannabis may have been one of the ingredients of the holy anointing oil mentioned in various sacred Hebrew texts.[48] The herb of interest is most commonly known as kaneh-bosm (Hebrew: -). This is mentioned several times in the Old Testament as a bartering material, incense, and an ingredient in holy anointing oil used by the high priest of the temple. Although Chris Bennett's research in this area focuses on cannabis, he mentions evidence suggesting use of additional visionary plants such as henbane, as well.[49]

The Septuagint translates kaneh-bosm as calamus, and this translation has been propagated unchanged to most later translations of the old testament. However, Polish anthropologist Sula Benet published etymological arguments that the Aramaic word for hemp can be read as kannabos and appears to be a cognate to the modern word 'cannabis',[50] with the root kan meaning reed or hemp and bosm meaning fragrant. Both cannabis and calamus are fragrant, reedlike plants containing psychotropic compounds.

In his research, Professor Dan Merkur points to significant evidence of an awareness within the Jewish mystical tradition recognizing manna as an entheogen, thereby substantiating with rabbinic texts theories advanced by the superficial biblical interpretations of Terence McKenna, R. Gordon Wasson and other ethnomycologists.

Although philologist John Marco Allegro has suggested that the self-revelation and healing abilities attributed to the figure of Jesus may have been associated with the effects of the plant medicines, this evidence is dependent on pre-Septuagint interpretation of Torah and Tenach. Allegro was the only non-Catholic appointed to the position of translating the Dead Sea scrolls. His extrapolations are often the object of scorn due to Allegro's non-mainstream theory of Jesus as a mythological personification of the essence of a "psychoactive sacrament". Furthermore, they conflict with the position of the Catholic Church with regard to transubstantiation and the teaching involving valid matter, form, and drug that of bread and wine (bread does not contain psychoactive drugs, but wine contains ethanol). Allegro's book The Sacred Mushroom and the Cross relates the development of language to the development of myths, religions, and cultic practices in world cultures. Allegro believed he could prove, through etymology, that the roots of Christianity, as of many other religions, lay in fertility cults, and that cult practices, such as ingesting visionary plants (or "psychedelics") to perceive the mind of God, persisted into the early Christian era, and to some unspecified extent into the 13th century with reoccurrences in the 18th century and mid-20th century, as he interprets the Plaincourault chapel's fresco to be an accurate depiction of the ritual ingestion of Amanita muscaria as the Eucharist.

The historical picture portrayed by the Entheos journal is of fairly widespread use of visionary plants in early Christianity and the surrounding culture, with a gradual reduction of use of entheogens in Christianity.[51] R. Gordon Wasson's book Soma prints a letter from art historian Erwin Panofsky asserting that art scholars are aware of many "mushroom trees" in Christian art.[52]

The question of the extent of visionary plant use throughout the history of Christian practice has barely been considered yet by academic or independent scholars. The question of whether visionary plants were used in pre-Theodosius Christianity is distinct from evidence that indicates the extent to which visionary plants were utilized or forgotten in later Christianity, including so-called "heretical" or "quasi-" Christian groups,[53] and the question of other groups such as elites or laity within "orthodox" Catholic practice.[54]

Daniel Merkur at the University of Toronto contends that a minority of Christian hermits and mystics could possibly have used entheogens, in conjunction with fasting, meditation, and prayer.[citation needed]

According to R.C. Parker, "The use of entheogens in the Vajrayana tradition has been documented by such scholars as Ronald M Davidson, William George Stablein, Bulcsu Siklos, David B. Gray, Benoytosh Bhattacharyya, Shashibhusan Das Gupta, Francesca Fremantle, Shinichi Tsuda, David Gordon White, Rene de Nebesky-Wojkowitz, James Francis Hartzell, Edward Todd Fenner, Ian Baker, Dr. Pasang Yonten Arya and numerous others."[55] These scholars have established entheogens were used in Vajrayana (in a limited context) as well as in Tantric Saivite traditions.[55] The major entheogens in the Vajrayana Anuttarayoga Tantra tradition are cannabis and Datura which were used in various pills, ointments, and elixirs. Several tantras within Vajrayana specifically mention these entheogens and their use, including the Laghusamvara-tantra (aka Cakrasavara Tantra), Samputa-tantra, Samvarodaya-tantra, Mahakala-tantra, Guhyasamaja-tantra, Vajramahabhairava-tantra, and the Krsnayamari-tantra.[55] In the Cakrasavara Tantra, the use of entheogens is coupled with mediation practices such as the use of a mandala of the Heruka meditation deity (yidam) and visualization practices which identify the yidam's external body and mandala with one's own body and 'internal mandala'.[56]

In the West, some modern Buddhist teachers have written on the usefulness of psychedelics. The Buddhist magazine Tricycle devoted their entire fall 1996 edition to this issue.[57] Some teachers such as Jack Kornfield have acknowledged the possibility that psychedelics could complement Buddhist practice, bring healing and help people understand their connection with everything which could lead to compassion.[58] Kornfield warns however that addiction can still be a hindrance. Other teachers such as Michelle McDonald-Smith expressed views which saw entheogens as not conductive to Buddhist practice ("I do
n't see them developing anything").[59]

R. Gordon Wasson and Giorgio Samorini have proposed several examples of the cultural use of entheogens that are found in the archaeological record.[60][61] Evidence for the first use of entheogens may come from Tassili, Algeria, with a cave painting of a mushroom-man, dating to 8000 BP.[citation needed] Hemp seeds discovered by archaeologists at Pazyryk suggest early ceremonial practices by the Scythians occurred during the 5th to 2nd century BC, confirming previous historical reports by Herodotus.[citation needed]

Although entheogens are taboo and most of them are officially prohibited in Christian and Islamic societies, their ubiquity and prominence in the spiritual traditions of various other cultures is unquestioned. "The spirit, for example, need not be chemical, as is the case with the ivy and the olive: and yet the god was felt to be within them; nor need its possession be considered something detrimental, like drugged, hallucinatory, or delusionary: but possibly instead an invitation to knowledge or whatever good the god's spirit had to offer."[62]

Most of the well-known modern examples, such as peyote, psilocybin mushrooms, and morning glories are from the native cultures of the Americas. However, it has also been suggested that entheogens played an important role in ancient Indo-European culture, for example by inclusion in the ritual preparations of the Soma, the "pressed juice" that is the subject of Book 9 of the Rig Veda. Soma was ritually prepared and drunk by priests and initiates and elicited a paean in the Rig Veda that embodies the nature of an entheogen:

Splendid by Law! declaring Law, truth speaking, truthful in thy works, Enouncing faith, King Soma!... O [Soma] Pavmana (mind clarifying), place me in that deathless, undecaying world wherein the light of heaven is set, and everlasting lustre shines.... Make me immortal in that realm where happiness and transports, where joy and felicities combine...

The kykeon that preceded initiation into the Eleusinian Mysteries is another entheogen, which was investigated (before the word was coined) by Carl Kernyi, in Eleusis: Archetypal Image of Mother and Daughter. Other entheogens in the Ancient Near East and the Aegean include the opium poppy, datura, and the unidentified "lotus" (likely the sacred blue lily) eaten by the Lotus-Eaters in the Odyssey and Narcissus.

According to Ruck, Eyan, and Staples, the familiar shamanic entheogen that the Indo-Europeans brought knowledge of was Amanita muscaria. It could not be cultivated; thus it had to be found, which suited it to a nomadic lifestyle. When they reached the world of the Caucasus and the Aegean, the Indo-Europeans encountered wine, the entheogen of Dionysus, who brought it with him from his birthplace in the mythical Nysa, when he returned to claim his Olympian birthright. The Indo-European proto-Greeks "recognized it as the entheogen of Zeus, and their own traditions of shamanism, the Amanita and the 'pressed juice' of Soma but better, since no longer unpredictable and wild, the way it was found among the Hyperboreans: as befit their own assimilation of agrarian modes of life, the entheogen was now cultivable."[62]Robert Graves, in his foreword to The Greek Myths, hypothesises that the ambrosia of various pre-Hellenic tribes was Amanita muscaria (which, based on the morphological similarity of the words amanita, amrita and ambrosia, is entirely plausible) and perhaps psilocybin mushrooms of the Panaeolus genus.

Amanita was divine food, according to Ruck and Staples, not something to be indulged in or sampled lightly, not something to be profaned. It was the food of the gods, their ambrosia, and it mediated between the two realms. It is said that Tantalus's crime was inviting commoners to share his ambrosia.

The entheogen is believed to offer godlike powers in many traditional tales, including immortality. The failure of Gilgamesh in retrieving the plant of immortality from beneath the waters teaches that the blissful state cannot be taken by force or guile: When Gilgamesh lay on the bank, exhausted from his heroic effort, the serpent came and ate the plant.

Another attempt at subverting the natural order is told in a (according to some) strangely metamorphosed myth, in which natural roles have been reversed to suit the Hellenic world-view. The Alexandrian Apollodorus relates how Gaia (spelled "Ge" in the following passage), Mother Earth herself, has supported the Titans in their battle with the Olympian intruders. The Giants have been defeated:

When Ge learned of this, she sought a drug that would prevent their destruction even by mortal hands. But Zeus barred the appearance of Eos (the Dawn), Selene (the Moon), and Helios (the Sun), and chopped up the drug himself before Ge could find it.[63]

The legends of the Assassins had much to do with the training and instruction of Nizari fida'is, famed for their public missions during which they often gave their lives to eliminate adversaries.

The tales of the fidais training collected from anti-Ismaili historians and orientalists writers were confounded and compiled in Marco Polos account, in which he described a "secret garden of paradise".[citation needed] After being drugged, the Ismaili devotees were said be taken to a paradise-like garden filled with attractive young maidens and beautiful plants in which these fidais would awaken. Here, they were told by an "old" man that they were witnessing their place in Paradise and that should they wish to return to this garden permanently, they must serve the Nizari cause.[64] So went the tale of the "Old Man in the Mountain", assembled by Marco Polo and accepted by Joseph von Hammer-Purgstall (17741856), a prominent orientalist writer responsible for much of the spread of this legend. Until the 1930s, von Hammers retelling of the Assassin legends served as the standard account of the Nizaris across Europe.[citation needed]

Notable early testing of the entheogenic experience includes the Marsh Chapel Experiment, conducted by physician and theology doctoral candidate, Walter Pahnke, under the supervision of Timothy Leary and the Harvard Psilocybin Project. In this double-blind experiment, volunteer graduate school divinity students from the Boston area almost all claimed to have had profound religious experiences subsequent to the ingestion of pure psilocybin. In 2006, a more rigorously controlled experiment was conducted at Johns Hopkins University, and yielded similar results.[65] To date there is little peer-reviewed research on this subject, due to ongoing drug prohibition and the difficulty of getting approval from institutional review boards.[66]

Furthermore, scientific studies on entheogens present some significant challenges to investigators, including philosophical questions relating to ontology, epistemology and objectivity.[67]

Between 2011 and 2012, the Australian Federal Government was considering changes to the Australian Criminal Code that would classify any plants containing any amount of DMT as "controlled plants".[68] DMT itself was already controlled under current laws. The proposed changes included other similar blanket bans for other substances, such as a ban on any and all plants containing Mescaline or Ephedrine. The proposal was not pursued after political embarrassment on realisation that this would make the official Floral Emblem of Australia, Acacia pycnantha (Golden Wattle), illegal. The Therapeutic Goods Administration and federal authority had considered a motion to ban the same, but this
was withdrawn in May 2012 (as DMT may still hold potential entheogenic value to native and/or religious peoples).[69]

In 1963 in Sherbert v. Verner the Supreme Court established the Sherbert Test, which consists of four criteria that are used to determine if an individual's right to religious free exercise has been violated by the government. The test is as follows:

For the individual, the court must determine

If these two elements are established, then the government must prove

This test was eventually all-but-eliminated in Employment Division v. Smith 494 U.S. 872 (1990), but was resurrected by Congress in the federal Religious Freedom Restoration Act (RFRA) of 1993.

In City of Boerne v. Flores, 521 U.S. 507 (1997) and Gonzales v. O Centro Esprita Beneficente Unio do Vegetal, 546 U.S. 418 (2006), the RFRA was held to trespass on state sovereignty, and application of the RFRA was essentially limited to federal law enforcement.

As of 2001, Arizona, Idaho, New Mexico, Oklahoma, South Carolina, and Texas had enacted so-called "mini-RFRAs."

Many works of literature have described entheogen use; some of those are:

Others

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Entheogen - Wikipedia, the free encyclopedia

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Entheogens including Salvia, LSD, Peyote, and Mushrooms …

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(Entheogen Defined) "'Entheogen' is a word coined by scholars proposing to replace the term 'psychedelic' (Ruck, Bigwood, Staples, Ott & Wasson, 1979), which was perceived to be too socioculturally loaded from its 1960s roots to appropriately denote the revered plants and substances used for traditional sacred rituals.What kinds of plants or chemicals fall into the category of entheogen is a matter of debate, as a large number of inebriants - from tobacco and marijuana to alcohol and opium - have been venerated as gifts from the gods (or God) in different cultures at different times (Fuller, 2000). For the purposes of this paper, however, I will focus on the class of drugs that Lewin (1924/1997) terms 'phantastica,' a name deriving from the Greek word for the faculty of the imagination (Shorter Oxford English Dictionary, 1973). Later these substances became known as hallucinogens or psychedelics, a class whose members include lysergic acid derivatives, psilocybin, mescaline and dimethyltryptamine; these all shared physical, chemical, and, when ingested, phenomenological properties and, more importantly, have a history of ritual use as cultural tools to cure illness and/or to mediate cosmological insight (Grinspoon & Bakalar, 1998; Rudgley, 1994, Schultes & Hofmann, 1992;)."

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(Entheogens as Psychedelics) "Another peculiar effect of these drugs is a dramatic change in perception: it appears to the person as if the eyes (the 'doors of perception') have been cleansed and the person could see the world as new in all respects 'as Adam may have seen it on the day of creation' as Aldous Huxley (1954, p. 17) pointed out in his popular and influential book. This new reality is perceived and interpreted by some individuals as manifestation of the true nature of their mind; hence, the term 'psychedelic' was suggested by Osmond (1957). This interpretation has been embraced not only by professional therapists but also by some segments of the public, and gave rise to the 'Summer of Love' in San Francisco in 1967 with free distribution of LSD. This perception resulted in the formation of numerous cults, communes, and drug-oriented religious groups (Freedman 1968), permeated the lyrics and style of popular music (acid rock), and was viewed by some as one of the contributing sources of the occasional resurgence of popularity of illegal drug use (Cohen 1966, Szra 1968)."

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(Entheogens as Hallucinogens) "The term 'hallucinogen' is widely used and understood in both professional and lay circles, in spite of the fact that hallucinations in the strict psychiatric sense of the word are a relatively rare effect of these drugs (Hollister 1962). What is probably the first reference to hallucinations as produced by peyote appears in Louis Lewins book published in 1924 in German and later translated into English with the nearly identical title Phantastica (Lewin 1924, 1964). In this book by the noted German toxicologist, the term 'hallucinatoria' appears as a synonym for phantastica to designate the class of drugs that can produce transitory visionary states 'without any physical inconvenience for a certain time in persons of perfectly normal mentality who are partly or fully conscious of the action of the drug' (Lewin 1964, p. 92). Lewin lists peyotl (also spelled 'peyote') (Anhalonium lewinii), Indian hemp (Cannabis indica), fly agaric (Agaricus muscarius), thornapple
(Datura stramonium), and the South American yahe (also spelled 'yage') (Banisteria caapi) as representatives of this class."

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(Description of Ayahuasca) "Ayahuasca is a hallucinogenic tea originally from the Amazon Basin that is supposedly able to induce strikingly similar visions in people independent of their cultural background. Ayahuasca users commonly claim that this regularity across peoples visions is evidence that their visions are not simply the products of their own brains, but rather are representations of spiritual information learned from plant-spirits that one gains access to by drinking the tea."

(Description of Ayahuasca) "Ayahuasca is a psychedelic decoction made from plants native to the Amazon Basinmost often Banisteriopsis caapi and Psychotria viridisand which contains harmala alkaloids and N,Ndimethyltryptamine (DMT), the latter being a controlled substance scheduled under the 1971 Convention on Psychotropic Substances."

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(Ayahuasca Folk Healers) "Vegetalismo is a Peruvian Spanish term denoting the folk healing traditions of mestizo curanderos, or healers of mixed indigenous and non-indigenous ancestry who use ayahuasca and other 'master' plants for diagnosis and treatment of illnesses (Beyer, 2009; Dobkin de Rios, 1972; Luna, 1986). Known as ayahuasqueros, such folk healers undergo a rigorous process of initiation and training, requiring adherence to strict dietary and sexual abstinence protocols, and sometimes prolonged isolation in the jungle."

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(Ayahuasca Healing Ceremonies) "Cross-cultural vegetalismo refers to ayahuasca ceremonies based, to varying degrees, on vegetalismo or equivalent traditions from other regions of the Amazon, but conducted primarily for (and increasingly by) non-Amazonians. Urban centres in the region are presently witnessing a boom in what has been pejoratively characterized as 'ayahuasca tourism' (Dobkin de Rios, 1994; see also Davidov, 2010; Holman, 2011; Razam, 2009), but cross-cultural vegetalismo ceremonies are also increasingly common outside the Amazon (Labate, 2004). Canadians and other foreigners regularly invite indigenous or mestizo Amazonian ayahuasqueros to their home countries to conduct ceremonies for people in the circles and networks of the sponsors friends and acquaintances (Tupper, 2009asee Appendix). Some individuals are undertaking apprenticeships in the vegetalismo tradition to become neo-shamanic practitioners of ayahuasca healing, in a manner similar to how yoga, Buddhist monastic, ayurvedic, or Chinese medicine practices have been taken up by modern Western disciples exogenous to the respective cultures and traditions of origin."

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(Legal Status of Ayahuasca) "On February 21 of this year, 2006, the US Supreme Court ruled in favor of the Centro Esprita Beneficente Unio do Vegetal (the UDV) in the case Alberto R. Gonzales, Attorney General, et al. Petitioners v. O Centro Espirita Beneficente Unio do Vegetal et al. The UDV is now legally allowed to drink ayahuasca (which contains the controlled substance DMT) in their ceremonies here in the US."

(Therapeutic Potential of Ayahuasca) "Aside from indicating a general lack
of harm from the religious use of ayahuasca, biomedical and ethnographic studies have also generated preliminary evidence in support of the therapeutic potentials of ayahuasca or its constituents for alleviating substance dependence (Grob et al., 1996; Labate, Santos, Anderson, Mercante, & Barbosa, 2010) and mood and anxiety disorders (Fortunato et al., 2010; Santos, Landeira-Fernandez, Strassman, Motta, & Cruz, 2007). The study of ayahuasca could thus contribute to advances in ethnopharmacology and the cognitive sciences (Shanon, 2002), yet such studies are severely compromised when these traditions face the threat of legal sanction."

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"LSD (d-lysergic acid diethylamide) is one of the most potent mood-changing chemicals. It was discovered in 1938 and is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains."

(NIDA's Description of the Physical Characteristics of LSD) "LSD (d-lysergic acid diethylamide)also known as acid, blotter, doses, hits, microdots, sugar cubes, trips, tabs, or window panes is one of the most potent moodand perception-altering hallucinogenic drugs. It is a clear or white, odorless, water-soluble material synthesized from lysergic acid, a compound derived from a rye fungus. LSD is initially produced in crystalline form, which can then be used to produce tablets known as 'microdots' or thin squares of gelatin called 'window panes.' It can also be diluted with water or alcohol and sold in liquid form. The most common form, however, is LSD-soaked paper punched into small individual squares, known as 'blotters.'"

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(LSD Effects According to NIDA) "Sensations and feelings change much more dramatically than the physical signs in people under the influence of LSD. The user may feel several different emotions at once or swing rapidly from one emotion to another. If taken in large enough doses, the drug produces delusions and visual hallucinations. The users sense of time and self is altered. Experiences may seem to cross over different senses, giving the user the feeling of hearing colors and seeing sounds. These changes can be frightening and can cause panic. Some LSD users experience severe, terrifying thoughts and feelings of despair, fear of losing control, or fear of insanity and death while using LSD. "LSD users can also experience flashbacks, or recurrences of certain aspects of the drug experience. Flashbacks occur suddenly, often without warning, and may do so within a few days or more than a year after LSD use. In some individuals, the flashbacks can persist and cause significant distress or impairment in social or occupational functioning, a condition known as hallucinogen-induced persisting perceptual disorder (HPPD). "Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered an addictive drug since it does not produce compulsive drug-seeking behavior. However, LSD does produce tolerance, so some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, cross-tolerance between LSD and other hallucinogens has been reported.

(Prevalence of and Trends in LSD Use Among Youth) "LSD, one of the major drugs in the hallucinogen class, showed a modest decline in use among
12th graders from 1975 to 1977, followed by considerable stability through 1981 (Figure 5-4g). Between 1981 and 1985, there was a second period of gradual decline, with annual prevalence of use falling from 6.5% to 4.4%. However, after 1985, annual prevalence began to rise very gradually to 5.6% by 1992, making it one of the few drugs to show a rise in use in that period. The increase continued through 1996, with annual prevalence reaching 8.8%, double the low point in 1985. After 1996, annual prevalence declined, including sharp decreases in 2002 and 2003, reaching 1.7% in 2006, the lowest LSD prevalence rate recorded since MTF began. By 2011 the rate was up slightly to 2.7%, having risen by a significant 0.7 percentage points in 2010. We believe that the decline prior to 2002 might have resulted in part from a displacement of LSD by sharply rising ecstasy use. After 2001, when ecstasy use itself began to decline, the sharp further decline in LSD use likely resulted from a drop in the availability of LSD, because attitudes generally have not moved in a way that could explain the fall in use, while perceived availability has."

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(LSD and Marijuana Use by women) "Our results indicate that this population of sexually active female adolescents and young adults have similar rates of lifetime use of LSD (13%) as reported in other surveys,1,30 and half of these young women report using LSD one or more times in the last year. Prior data suggests that the use of hallucinogens by African Americans is virtually nonexistent across all ages of adolescents and young adults.2,9 In fact, we found that none of our African American young women reported using LSD. However, the proportion of African Americans who reported using marijuana was much greater than either caucasian or Mexican American women."

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(Effects of LSD) "The physiological effects of this powerful drug have been well documented. These effects can be grouped into five general areas of action: LSD works on the sympathetic nervous system (which is involved in regulation of heart muscle, smooth muscle and glandular organs in a response to stressful situations); the motor system (which is involved in carrying out limb movements); the affective states; thought processes; and it has profound effects upon the sensory and perceptual experience.

"LSD is a semisynthetic preparation originally derived from ergot, an extract of the fungus Claviceps purpurea, which grows as a parasite on rye wheat. The dosage that is required to produce a moderate effect in most subjects is 1 to 3mcg per kilogram of body mass, and the effects can last from seven to 10 hours (Bowman & Rand 1980).

"Stimulation of the sympathetic nervous system following LSD ingestion can lead to effects such as hypothermia with piloerection (hairs standing on end, such as can be found in reports of religious ecstasy), sweating, increased heart rate with palpitations, and elevation of blood pressure and blood glucose levels. These reactions of the autonomic nervous system are not as significant as other effects upon the body: action on the motor system can lead to increased activity of monosynaptic reflexes (such as the knee-jerk response), an increase in muscle tension, tremors, and muscular incoordination. This latter effect of muscular incoordination is also a symptom of religious ecstasy in many cultures, where the worshipper has such a profound feeling of love of God that he is said to be 'intoxi
cated by God.'"

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(Creation of LSD) "Chemist Albert Hofmann, working at the Sandoz Corporation pharmaceutical laboratory in Switzerland, first synthesized LSD in 1938. He was conducting research on possible medical applications of various lysergic acid compounds derived from ergot, a fungus that develops on rye grass. Searching for compounds with therapeutic value, Hofmann created more than two dozen ergot-derived synthetic molecules. The 25th was called, in German, Lyserg-Sure-Dithylamid 25, or LSD-25."

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(Addictive Properties and Tolerance) "Most users of LSD voluntarily decrease or stop its use over time. LSD is not considered an addictive drug since it does not produce compulsive drug-seeking behavior. However, LSD does produce tolerance, so some users who take the drug repeatedly must take progressively higher doses to achieve the state of intoxication that they had previously achieved. This is an extremely dangerous practice, given the unpredictability of the drug. In addition, cross-tolerance between LSD and other hallucinogens has been reported."

(Physical Effects of LSD According to NIDA) "The effects of LSD depend largely on the amount taken. LSD causes dilated pupils; can raise body temperature and increase heart rate and blood pressure; and can cause profuse sweating, loss of appetite, sleeplessness, dry mouth, and tremors."

(Description of Peyote) "Peyote is a small, spineless cactus in which the principal active ingredient is mescaline. This plant has been used by natives in northern Mexico and the southwestern United States as a part of religious ceremonies. Mescaline can also be produced through chemical synthesis."

(Description of Peyote) "The top of the peyote cactus, also referred to as the crown, consists of disc-shaped buttons that are cut from the roots and dried. These buttons are generally chewed or soaked in water to produce an intoxicating liquid. The hallucinogenic dose of mescaline is about 0.3 to 0.5 grams, and its effects last about 12 hours. Because the extract is so bitter, some individuals prefer to prepare a tea by boiling the cacti for several hours."

(Effects of Mescaline and Peyote) "The long-term residual psychological and cognitive effects of mescaline, peyotes principal active ingredient, remain poorly understood. A recent study found no evidence of psychological or cognitive deficits among Native Americans that use peyote regularly in a religious setting.2 It should be mentioned, however, that these findings may not generalize to those who repeatedly abuse the drug for recreational purposes. Peyote abusers may also experience flashbacks."

(Physical Effects) "Its effects can be similar to those of LSD, including increased body temperature and heart rate, uncoordinated movements (ataxia), profound sweating, and flushing. The active ingredient mescaline has also been associated, in at least one report, to fetal abnormalities."

"Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) is obtained from certain types of mushrooms that are indigenous to tropical and subtropical regions of South America, Mexico, and the United States. These mushrooms typically contain less than 0.5 percent psilocybin plus trace amounts of psilocin, another
hallucinogenic substance."

(Methods of Use) "Mushrooms containing psilocybin are available fresh or dried and are typically taken orally. Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) and its biologically active form, psilocin (4-hydroxy-N,N-dimethyltryptamine), cannot be inactivated by cooking or freezing preparations. Thus, they may also be brewed as a tea or added to other foods to mask their bitter flavor. The effects of psilocybin, which appear within 20 minutes of ingestion, last approximately 6 hours."

(Effects of Psilocybin) "The active compounds in psilocybin-containing 'magic' mushrooms have LSD-like properties and produce alterations of autonomic function, motor reflexes, behavior, and perception.3 The psychological consequences of psilocybin use include hallucinations, an altered perception of time, and an inability to discern fantasy from reality. Panic reactions and psychosis also may occur, particularly if a user ingests a large dose. Long-term effects such as flashbacks, risk of psychiatric illness, impaired memory, and tolerance have been described in case reports."

(Physical Effects of Psilocybin) "[Psilocybin] can produce muscle relaxation or weakness, ataxia, excessive pupil dilation, nausea, vomiting, and drowsiness. Individuals who abuse psilocybin mushrooms also risk poisoning if one of many existing varieties of poisonous mushrooms is incorrectly identified as a psilocybin mushroom."

(Psilocybin and Mystical Experiences) "Overall, the present study shows that psilocybin can dose-dependently occasion mystical-type experiences having persisting positive effects on attitudes, mood, and behavior. The observations that episodes of extreme fear, feeling trapped, or delusions occur at the highest dose in almost 40% of volunteers, that anxiety and fear have an unpredictable time course across the session, and that an ascending sequence of dose exposure may be associated with long-lasting positive changes have implications for the design of therapeutic trials with psilocybin. Considering the rarity of spontaneous mystical experiences in the general population, the finding that more than 70% of volunteers in the current study had 'complete' mystical experiences suggests that most people have the capacity for such experiences under appropriate conditions and, therefore, such experiences are biologically normal."

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(Safety of Psilocybin) "An important finding of the present study is that, with careful volunteer screening and preparation and when sessions are conducted in a comfortable, well-supervised setting, a high dose of 30 mg/70 kg psilocybin can be administered safely. . It is also noteworthy that, despite meetings and prior sessions with monitors ranging from 8 h (when psilocybin was administered on the first session) up to 24 h (when psilocybin was administered on the third session) of contact time, 22% (8 of 36) of the volunteers experienced a period of notable anxiety/dysphoria during the session, sometimes including transient ideas of reference/paranoia. No volunteer required pharmacological intervention and the psychological effects were readily managed with reassurance. The primary monitor remained accessible via beeper/phone to each volunteer for 24 h after each session, but no volunteer called before the scheduled follow-up meeting on the next day. The 1-year follow-up is ongoing but has
been completed by most volunteers (30 of 36). In that follow-up, an open-ended clinical interview reflecting on the study experiences and current life situation provides a clinical context conducive to the spontaneous reporting of study-associated adverse events. To date, there have been no reports of persisting perceptional phenomena sometimes attributed to hallucinogen use or of recreational abuse of hallucinogens, and all participants appear to continue to be high-functioning, productive members of society."

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(Medicinal Potential of Psilocybin) "Today, the medical value of hallucinogens is again being examined in formal psychiatric settings. One substance under investigation is psilocybin, 4-phosphoryloxy-N,N-dimethyltryptamine, which occurs in nature in various species of mushrooms. Psilocybin is rapidly metabolized to psilocin, which is a potent agonist at serotonin 5-HT1A/2A/2C receptors, with 5-HT2A receptor activation directly correlated with human hallucinogenic activity.16 Psilocybin was studied during the 1960s to establish its psychopharmacological profile; it was found to be active orally at around 10 mg, with stronger effects at higher doses, and to have a 4- to 6-hour duration of experience. Psychological effects were similar to those of lysergic acid diethylamide (LSD), with psilocybin considered to be more strongly visual, less emotionally intense, more euphoric, and with fewer panic reactions and less chance of paranoia than LSD."17,18

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(Safety of Psilocybin in Clinical Setting) "Our investigations provided no cause for concern that administration of PY [psilocybin] to healthy subjects is hazardous with respect to somatic health. However, as our data revealed tendencies of PY to temporarily increase blood pressure, we advise subjects suffering from cardiovascular conditions, especially untreated hypertension, to abstain from using PY or PY-containing mushrooms. Furthermore, our results indicate that PY-induced ASC [altered states of consciousness] are generally well tolerated and integrated by healthy subjects. However, a controlled clinical setting is needful, since also mentally stable personalities may, following ingestion of higher doses of PY, transiently experience anxiety as a consequence of loosening of ego-boundaries."

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(Psilocybin and Treatment of End-Stage Cancer Anxiety) "Despite the limitations, this study demonstrates that the careful and controlled use of psilocybin may provide an alternative model for the treatment of conditions that are often minimally responsive to conventional therapies, including the profound existential anxiety and despair that often accompany advanced-stage cancers. A recent review from the psilocybin research group at Johns Hopkins University describes the critical components necessary for ensuring subject safety in hallucinogen research.36 Taking into account these essential provisions for optimizing safety as well as adhering to strict ethical standards of conduct for treatment facilitators, the results provided herein indicate the safety and promise of continued investigations into the range of medical effects of hallucinogenic compounds such as psilocybin."

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(Description of Salvia Divinorum) "Salvia divinorum is a
perennial herb in the mint family native to certain areas of the Sierra Mazateca region of Oaxaca, Mexico. The plant, which can grow to over three feet in height, has large green leaves, hollow square stems and white flowers with purple calyces, can also be grown successfully outside of this region. Salvia divinorum has been used by the Mazatec Indians for its ritual divination and healing. The active constituent of Salvia divinorum has been identified as salvinorin A. Currently, neither Salvia divinorum nor any of its constituents, including salvinorin A, are controlled under the federal Controlled Substances Act (CSA)."

(Effects of Salvia Divinorum) "Consistent with results from nonhuman animal research (Mowry et al.,2003), the present results suggest a safe physiological profile for salvinorin A at the studied doses, under controlled conditions, and in psychologically and physically healthy hallucinogen-experienced participants. Salvinorin A produced no significant changes in heart rate or blood pressure; no tremor was observed; and no adverse events were reported. Participants tolerated all doses. However, because of the small sample and the healthy, hallucinogen-experienced status of participants, conclusions regarding safety are limited."

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(Description of Salvia and Its Effects) "Salvia divinorum is a psychoactive plant that can induce dissociative effects and is a potent producer of visual and other hallucinatory experiences. By mass, salvinorin A, the psychoactive substance in the plant, appears to be the most potent naturally occurring hallucinogen. Its native habitat is the cloud forests in Mexico. It has been consumed for hundreds of years by local Mazatec shamans, who use it to facilitate visionary states of consciousness during spiritual healing sessions.57 It is also used in traditional medicine at lower doses as a diuretic to treat ailments including diarrhoea, anaemia, headaches and rheumatism. Effects include various psychedelic experiences, including past memories (e.g. revisiting places from childhood memory), merging with objects and overlapping realities (such as the perception of being in several locations at the same time).58 In contrast to other drugs, its use often prompts dysphoria, i.e. feelings of sadness and depression, as well as fear. In addition, it may prompt a decreased heart rate, slurred speech, lack of coordination and possibly loss of consciousness.59"

(Effects of Salvia Divinorum) "The putative primary psychoactive agent in SD [Salvia divinorum] is a structurally novel KOR [kappa opioid receptor] agonist named salvinorin A (Ortega et al., 1982; Valds et al., 1984). Consistent with KOR agonist activity, users describe SD in lay literature as hallucinogenic: it produces perceptual distortions, pseudo-hallucinations, and a profoundly altered sense of self and environment, including out-of-body experiences (Aardvark, 1998; Erowid, 2008; Siebert, 1994b; Turner, 1996). SD therefore appears to have the potential to elucidate the role of the KOR receptor system in health and disease (Butelman et al., 2004; Chavkin et al., 2004; Roth et al., 2002)."

(Potential for Abuse or Dependence of Salvia Divinorum) "There was little evidence of dependence in our survey population. At some point, 0.6% (3 people) felt addicted to or dependent upon SD, while 1.2% (6) reported strong cravings for SD. The DSM-IV-R
psychiatric diagnostic system in the United States classifies people as drug dependent based on seven criteria. Of the three who reported feelings of addiction or dependence on SD, only one endorsed any DSM-IV criteria (strong cravings and using more SD than planned). When asked about these signs and symptoms individually, 2 additional respondents (0.4%) reported three dependence criteria. None of these individuals reported more than 2 of 13 after-effects characteristic of mu-opioid withdrawal (such as increased sweating, gooseflesh, worsened mood, and diarrhea)."

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(Prevalence of Use of Salvia Divinorum Among Youth) "A tripwire question about use of salvia (or salvia divinorum) in the past 12 months was added in 2010. Salvia is an herb with hallucinogenic properties, common to southern Mexico and Central and South America. Although it currently is not a drug regulated by the Controlled Substances Act, several states have passed legislation to regulate its use. The Drug Enforcement Agency has listed salvia as a drug of concern and is considering classifying it as a Schedule I drug, like LSD or marijuana. The drug has an appreciable annual prevalence: 1.6%, 3.9%, and 5.9% among 8th, 10th, and 12th graders in 2011, while lifetime prevalence would be somewhat higher."

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Entheogens including Salvia, LSD, Peyote, and Mushrooms ...

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Entheogens & Existential Intelligence: The Use of Plant …

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Used with permission. The official published version : http://www.csse.ca/CJE/Articles/FullText/CJE27-4/CJE27-4-tupper.pdf

Painting by Yvonne McGillivray

In light of recent specific liberalizations in drug laws in some countries, this article investigates the potential of entheogens (i.e. psychoactive plants used as spiritual sacraments) as tools to facilitate existential intelligence. Plant teachers from the Americas such as ayahuasca, psilocybin mushrooms, peyote, and the Indo-Aryan soma of Eurasia are examples of both past- and presently-used entheogens. These have all been revered as spiritual or cognitive tools to provide a richer cosmological understanding of the world for both human individuals and cultures. I use Howard Gardners (1999a) revised multiple intelligence theory and his postulation of an existential intelligence as a theoretical lens through which to account for the cognitive possibilities of entheogens and explore potential ramifications for education.

In this article I assess and further develop the possibility of an existential intelligence as postulated by Howard Gardner (1999a). Moreover, I entertain the possibility that some kinds of psychoactive substancesentheogenshave the potential to facilitate this kind of intelligence. This issue arises from the recent liberalization of drug laws in several Western industrialized countries to allow for the sacramental use of ayahuasca, a psychoactive tea brewed from plants indigenous to the Amazon. I challenge readers to step outside a long-standing dominant paradigm in modern Western culture that a priori regards hallucinogenic drug use as necessarily maleficent and devoid of any merit. I intend for my discussion to confront assumptions about drugs that have unjustly perpetuated the disparagement and prohibition of some kinds of psychoactive substance use. More broadly, I intend for it to challenge assumptions about intelligence that constrain contemporary educational thought.

Entheogen is a word coined by scholars proposing to replace the term psychedelic (Ruck, Bigwood, Staples, Ott, & Wasson, 1979), which was felt to overly connote psychological and clinical paradigms and to be too socio-culturally loaded from its 1960s roots to appropriately designate the revered plants and substances used in traditional rituals. I use both terms in this article: entheogen when referring to a substance used as a spiritual or sacramental tool, and psychedelic when referring to one used for any number of purposes during or following the so-called psychedelic era of the 1960s (recognizing that some contemporary non-indigenous uses may be entheogenicthe categories are by no means clearly discreet). What kinds of plants or chemicals fall into the category of entheogen is a matter of debate, as a large number of inebriantsfrom coca and marijuana to alcohol and opiumhave been venerated as gifts from the gods (or God) in different cultures at different times. For the purposes of this article, however, I focus on the class of drugs that Lewin (1924/1997) termed phantastica, a name deriving from the Greek word for the faculty of imagination (Shorter Oxford English Dictionary, 1973). Later these substances became known as hallucinogens or psychedelics, a class whose members include lysergic acid derivatives, psilocybin, mescaline and dimethyltryptamine. With the exception of mescaline, these all share similar chemical structures; all, including mescaline, produce similar phenomenological effects; and, more importantly for the present discussion, all have a history of ritual use as psychospiritual medicines or, as I argue, cultural tools to facilitate cognition (Schultes & Hofmann, 1992).

The issue of entheogen use in modern Western culture becomes more significant in light of several legal precedents in countries such as Brazil, Holland, Spain and soon perhaps the United States and Canada. Ayahuasca, which I discuss in more detail in the following section on plant teachers, was legalized for religious use by non-indigenous people in Brazil in 1987i. One Brazilian group, the Santo Daime, was using its sacrament in ceremonies in the Netherlands when, in the autumn of 1999, authorities intervened and arrested its leaders. This was the first case of religious intolerance by a Dutch government in over three hundred years. A subsequent legal challenge, based on European Union religious freedom laws, saw them acquitted of all charges, setting a precedent for the rest of Europe (Adelaars, 2001). A similar case in Spain resulted in the Spanish government granting the right to use ayahuasca in that country. A recent court decision in the United States by the 10th Circuit Court of Appeals, September 4th, 2003, ruled in favour of religious freedom to use ayahuasca (Center for Cognitive Liberty and Ethics, 2003). And in Canada, an application to Health Canada and the Department of Justice for exemption to the Controlled Drugs and Substances Act is pending, which may permit the Santo Daime Church the religious use of their sacrament, known as Daime or Santo Daimeii (J.W. Rochester, personal communication, October 8th, 2003)

One of the questions raised by this trend of liberalization in otherwise prohibitionist regulatory regimes is what benefits substances such as ayahuasca have. The discussion that follows takes up this question with respect to contemporary psychological theories about intelligence and touches on potential ramifications for education. The next section examines the metaphor of plant teachers, which is not uncommon among cultures that have traditionally practiced the entheogenic use of plants. Following that, I use Howard Gardners theory of multiple intelligences (1983) as a theoretical framework with which to account for cognitive implications of entheogen use. Finally, I take up a discussion of possible relevance of existential intelligence and entheogens to education.

Before moving on to a broader discussion of intelligence(s), I will provide some background on ayahuasca and entheogens. Ayahuasca has been a revered plant teacher among dozens of South American indigenous peoples for centuries, if not longer (Luna, 1984; Schultes & Hofmann, 1992). The word ayahuasca is from the Quechua language of indigenous peoples of Ecuador and Peru, and translates as vine of the soul (Metzner, 1999). Typically, it refers to a tea made from a jungle liana, Banisteriopsis caapi, with admixtures of other plants, but most commonly the leaves of a plant from the coffee family, Psychotria viridis (McKenna, 1999). These two plants respectively contain harmala alkaloids and dimethyltryptamine, two substances that when ingested orally create a biochemical synergy capable of producing profound alterations in consciousness (Grob, et al., 1996; McKenna, Towers & Abbot, 1984). Among the indigenous peoples of the Amazon, ayahuasca is one of the most valuable medicinal and sacramental plants in their pharmacopoeias. Although shamans in different tribes use the tea for various purposes, and have varying recipes for it, the application of ayahuasca as an effective tool to attain understanding and wisdom is one of the most prevalent (Brown, 1986; Dobkin de Rios, 1984).

Notwithstanding the explosion of popular interest in psychoactive drugs during the 1960s, ayahuasca until quite recently managed to remain relatively obscure in Western cultureiii. However, the late 20th century saw the growth of religious movements among non-indigenous people in Brazil syncretizing the use of ayahuasca with Christian symbolism, African spiritualism, and native ritual. Two of the more widespread ayahuasca churches are the Santo Daime (Sant
o Daime, 2004) and the Unio do Vegetal (Unio do Vegetal, 2004). These organizations have in the past few decades gained legitimacy as valid, indeed valuable, spiritual practices providing social, psychological and spiritual benefits (Grob, 1999; Riba, et al., 2001).

Ayahuasca is not the only plant teacher in the pantheon of entheogenic tools. Other indigenous peoples of the Americas have used psilocybin mushrooms for millennia for spiritual and healing purposes (Dobkin de Rios, 1973; Wasson, 1980). Similarly, the peyote cactus has a long history of use by Mexican indigenous groups (Fikes, 1996; Myerhoff, 1974; Stewart, 1987), and is currently widely used in the United States by the Native American Church (LaBarre, 1989; Smith & Snake, 1996). And even in the early history of Western culture, the ancient Indo-Aryan texts of the Rig Veda sing the praises of the deified Soma (Pande, 1984). Although the taxonomic identity of Soma is lost, it seems to have been a plant or mushroom and had the power to reliably induce mystical experiencesan entheogen par excellence (Eliade, 1978; Wasson, 1968). The variety of entheogens extends far beyond the limited examples I have offered here. However, ayahuasca, psilocybin mushrooms, peyote and Soma are exemplars of plants which have been culturally esteemed for their psychological and spiritual impacts on both individuals and communities.

In this article I argue that the importance of entheogens lies in their role as tools, as mediators between mind and environment. Defining a psychoactive drug as a toolperhaps a novel concept for someinvokes its capacity to effect a purposeful change on the mind/body. Commenting on Vygotskys notions of psychological tools, John-Steiner and Souberman (1978) note that tool use has . . . important effects upon internal and functional relationships within the human brain (p. 133). Although they were likely not thinking of drugs as tools, the significance of this observation becomes even more literal when the tools in question are plants or chemicals ingested with the intent of affecting consciousness through the manipulation of brain chemistry. Indeed, psychoactive plants or chemicals seem to defy the traditional bifurcation between physical and psychological tools, as they affect the mind/body (understood by modern psychologists to be identical).

It is important to consider the degree to which the potential of entheogens comes not only from their immediate neuropsychological effects, but also from the social practicesritualsinto which their use has traditionally been incorporated (Dobkin de Rios, 1996; Smith, 2000). The protective value that ritual provides for entheogen use is evident from its universal application in traditional practices (Weil, 1972/1986). Medical evidence suggests that there are minimal physiological risks associated with psychedelic drugs (Callaway, et al., 1999; Grinspoon & Bakalar, 1979/1998; Julien, 1998). Albert Hofmann (1980), the chemist who first accidentally synthesized and ingested LSD, contends that the psychological risks associated with psychedelics in modern Western culture are a function of their recreational use in unsafe circumstances. A ritual context, however, offers psychospiritual safeguards that make the potential of entheogenic plant teachers to enhance cognition an intriguing possibility.

Howard Gardner (1983) developed a theory of multiple intelligences that originally postulated seven types of intelligence (iv). Since then, he has added a naturalist intelligence and entertained the possibility of a spiritual intelligence (1999a; 1999b). Not wanting to delve too far into territory fraught with theological pitfalls, Gardner (1999a) settled on looking at existential intelligence rather than spiritual intelligence (p. 123). Existential intelligence, as Gardner characterizes it, involves having a heightened capacity to appreciate and attend to the cosmological enigmas that define the human condition, an exceptional awareness of the metaphysical, ontological and epistemological mysteries that have been a perennial concern for people of all cultures (1999a).

In his original formulation of the theory, Gardner challenges (narrow) mainstream definitions of intelligence with a broader one that sees intelligence as the ability to solve problems or to fashion products that are valued in at least one culture or community (1999a, p. 113). He lays out eight criteria, or signs, that he argues should be used to identify an intelligence; however, he notes that these do not constitute necessary conditions for determining an intelligence, merely desiderata that a candidate intelligence should meet (1983, p. 62). He also admits that none of his original seven intelligences fulfilled all the criteria, although they all met a majority of the eight. For existential intelligence, Gardner himself identifies six which it seems to meet; I will look at each of these and discuss their merits in relation to entheogens.

One criterion applicable to existential intelligence is the identification of a neural substrate to which the intelligence may correlate. Gardner (1999a) notes that recent neuropsychological evidence supports the hypothesis that the brains temporal lobe plays a key role in producing mystical states of consciousness and spiritual awareness (p. 124-5; LaPlante, 1993; Newberg, DAquili & Rause, 2001). He also recognizes that certain brain centres and neural transmitters are mobilized in [altered consciousness] states, whether they are induced by the ingestion of substances or by a control of the will (Gardner, 1999a, p.125). Another possibility, which Gardner does not explore, is that endogenous dimethyltryptamine (DMT) in humans may play a significant role in the production of spontaneous or induced altered states of consciousness (Pert, 2001). DMT is a powerful entheogenic substance that exists naturally in the mammalian brain (Barker, Monti & Christian, 1981), as well as being a common constituent of ayahuasca and the Amazonian snuff, yopo (Ott, 1994). Furthermore, DMT is a close analogue of the neurotransmitter 5-hydroxytryptamine, or serotonin. It has been known for decades that the primary neuropharmacological action of psychedelics has been on serotonin systems, and serotonin is now understood to be correlated with healthy modes of consciousness.

One psychiatric researcher has recently hypothesized that endogenous DMT stimulates the pineal gland to create such spontaneous psychedelic states as near-death experiences (Strassman, 2001). Whether this is correct or not, the role of DMT in the brain is an area of empirical research that deserves much more attention, especially insofar as it may contribute to an evidential foundation for existential intelligence.

Another criterion for an intelligence is the existence of individuals of exceptional ability within the domain of that intelligence. Unfortunately, existential precocity is not something sufficiently valued in modern Western culture to the degree that savants in this domain are commonly celebrated today. Gardner (1999a) observes that within Tibetan Buddhism, the choosing of lamas may involve the detection of a predisposition to existential intellect (if it is not identifying the reincarnation of a previous lama, as Tibetan Buddhists themselves believe) (p. 124). Gardner also cites Czikszentmilhalyis consideration of the early-emerging concerns for cosmic issues of the sort reported in the childhoods of future religious leaders like Gandhi and of several future physicists (Gardner, 1999a, p. 124; Czikszentmilhalyi, 1996). Presumably, some individuals who are enjoined to enter a monastery or nunnery at a young age may be
so directed due to an appreciable manifestation of existential awareness. Likewise, individuals from indigenous cultures who take up shamanic practicewho have abilities beyond others to dream, to imagine, to enter states of trance (Larsen, 1976, p. 9)often do so because of a significant interest in cosmological concerns at a young age, which could be construed as a prodigious capacity in the domain of existential intelligencev (Eliade, 1964; Greeley, 1974; Halifax, 1979).

The third criterion for determining an intelligence that Gardner suggests is an identifiable set of core operational abilities that manifest that intelligence. Gardner finds this relatively unproblematic and articulates the core operations for existential intelligence as:

the capacity to locate oneself with respect to the farthest reaches of the cosmosthe infinite no less than the infinitesimaland the related capacity to locate oneself with respect to the most existential aspects of the human condition: the significance of life, the meaning of death, the ultimate fate of the physical and psychological worlds, such profound experiences as love of another human being or total immersion in a work of art. (1999a, p. 123)

Gardner notes that as with other more readily accepted types of intelligence, there is no specific truth that one would attain with existential intelligencefor example, as musical intelligence does not have to manifest itself in any specific genre or category of music, neither does existential intelligence privilege any one philosophical system or spiritual doctrine. As Gardner (1999a) puts it, there exists [with existential intelligence] a species potentialor capacityto engage in transcendental concerns that can be aroused and deployed under certain circumstances (p. 123). Reports on uses of psychedelics by Westerners in the 1950s and early 1960sgenerated prior to their prohibition and, some might say, profanationreveal a recurrent theme of spontaneous mystical experiences that are consistent with enhanced capacity of existential intelligence (Huxley, 1954/1971; Masters & Houston, 1966; Pahnke, 1970; Smith, 1964; Watts, 1958/1969).

Another criterion for admitting an intelligence is identifying a developmental history and a set of expert end-state performances for it. Pertaining to existential intelligence, Gardner notes that all cultures have devised spiritual or metaphysical systems to deal with the inherent human capacity for existential issues, and further that these respective systems invariably have steps or levels of sophistication separating the novice from the adept. He uses the example of Pope John XXIIIs description of his training to advance up the ecclesiastic hierarchy as a contemporary illustration of this point (1999a, p. 124). However, the instruction of the neophyte is a manifest part of almost all spiritual training and, again, the demanding process of imparting of shamanic wisdomoften including how to effectively and appropriately use entheogensis an excellent example of this process in indigenous cultures (Eliade, 1964).

A fifth criterion Gardner suggests for an intelligence is determining its evolutionary history and evolutionary plausibility. The self-reflexive question of when and why existential intelligence first arose in the Homo genus is one of the perennial existential questions of humankind. That it is an exclusively human trait is almost axiomatic, although a small but increasing number of researchers are willing to admit the possibility of higher forms of cognition in non-human animals (Masson & McCarthy, 1995; Vonk, 2003). Gardner (1999a) argues that only by the Upper Paleolithic period did human beings within a culture possess a brain capable of considering the cosmological issues central to existential intelligence (p. 124) and that the development of a capacity for existential thinking may be linked to a conscious sense of finite space and irreversible time, two promising loci for stimulating imaginative explorations of transcendental spheres (p. 124). He also suggests that thoughts about existential issues may well have evolved as responses to necessarily occurring pain, perhaps as a way of reducing pain or better equipping individuals to cope with it (Gardner, 1999a, p. 125). As with determining the evolutionary origin of language, tracing a phylogenesis of existential intelligence is conjectural at best. Its role in the development of the species is equally difficult to assess, although Winkelman (2000) argues that consciousness and shamanic practicesand presumably existential intelligence as wellstem from psychobiological adaptations integrating older and more recently evolved structures in the triune hominid brain. McKenna (1992) goes even so far as to postulate that the ingestion of psychoactive substances such as entheogenic mushrooms may have helped stimulate cognitive developments such as existential and linguistic thinking in our proto-human ancestors. Some researchers in the 1950s and 1960s found enhanced creativity and problem-solving skills among subjects given LSD and other psychedelic drugs (Harman, McKim, Mogar, Fadiman & Stolaroff, 1966; Izumi, 1970; Krippner, 1985; Stafford & Golightly, 1967), skills which certainly would have been evolutionarily advantageous to our hominid ancestors. Such avenues of investigation are beginning to be broached again by both academic scholars and amateur psychonauts (Dobkin de Rios & Janiger, 2003; Spitzer, et al., 1996; MAPS Bulletin, 2000).

The final criterion Gardner mentions as applicable to existential intelligence is susceptibility to encoding in a symbol system. Here, again, Gardner concedes that there is abundant evidence in favour of accepting existential thinking as an intelligence. In his words, many of the most important and most enduring sets of symbol systems (e.g., those featured in the Catholic liturgy) represent crystallizations of key ideas and experiences that have evolved within [cultural] institutions (1999a, p. 123). Another salient example that illustrates this point is the mytho-symbolism ascribed to ayahuasca visions among the Tukano, an Amazonian indigenous people. Reichel-Dolmatoff (1975) made a detailed study of these visions by asking a variety of informants to draw representations with sticks in the dirt (p. 174). He compiled twenty common motifs, observing that most of them bear a striking resemblance to phosphene patterns (i.e. visual phenomena perceived in the absence of external stimuli or by applying light pressure to the eyeball) compiled by Max Knoll (Oster, 1970). The Tukano interpret these universal human neuropsychological phenomena as symbolically significant according to their traditional ayahuasca-steeped mythology, reflecting the codification of existential ideas within their culture.

Narby (1998) also examines the codification of symbols generated during ayahuasca experiences by tracing similarities between intertwining snake motifs in the visions of Amazonian shamans and the double-helix structure of deoxyribonucleic acid. He found remarkable similarities between representations of biological knowledge by indigenous shamans and those of modern geneticists. More recently, Narby (2002) has followed up on this work by bringing molecular biologists to the Amazon to participate in ayahuasca ceremonies with experiences shamans, an endeavour he suggests may provide useful cross-fertilization in divergent realms of human knowledge.

The two other criteria of an intelligence are support from experimental psychological tasks and support from psychometric findings. Gardner suggests that existential intelligence is more debatable within these domains, citing personality invent
ories that attempt to measure religiosity or spirituality; he notes, it remains unclear just what is being probed by such instruments and whether self-report is a reliable index of existential intelligence (1999a, p. 125). It seems transcendental states of consciousness and the cognition they engender do not lend themselves to quantification or easy replication in psychology laboratories. However, Strassman, Qualls, Uhlenhuth, & Kellner (1994) developed a psychometric instrumentthe Hallucinogen Rating Scaleto measure human responses to intravenous administration of DMT, and it has since been reliably used for other psychedelic experiences (Riba, Rodriguez-Fornells, Strassman, & Barbanoj, 2001).

One historical area of empirical psychological research that did ostensibly stimulate a form of what might be considered existential intelligence was clinical investigations into psychedelics. Until such research became academically unfashionable and then politically impossible in the early 1970s, psychologists and clinical researchers actively explored experimentally-induced transcendent experiences using drugs in the interests of both pure science and applied medical treatments (Abramson, 1967; Cohen, 1964; Grinspoon & Bakalar, 1979/1998; Masters & Houston, 1966). One of the more famous of these was Pahnkes (1970) so-called Good Friday experiment, which attempted to induce spiritual experiences with psilocybin within a randomized double-blind control methodology. His conclusion that mystical experiences were indeed reliably produced, despite methodological problems with the study design, was borne out by a critical long-term follow-up (Doblin, 1991), which raises intriguing questions about both entheogens and existential intelligence.

Studies such as Pahnkes (1970), despite their promise, were prematurely terminated due to public pressure from a populace alarmed by burgeoning contemporary recreational drug use. Only about a decade ago did the United States government give researchers permission to renew (on a very small scale) investigations into psychedelics (Strassman 2001; Strassman & Qualls, 1994). Cognitive psychologists are also taking an interest in entheogens such as ayahuasca (Shanon, 2002). Regardless of whether support for existential intelligence can be established psychometrically or in experimental psychological tasks, Gardners theory expressly stipulates that not all eight criteria must be uniformly met in order for an intelligence to qualify. Nevertheless, Gardner claims to find the phenomenon perplexing enough, and the distance from other intelligences great enough (1999a, p. 127) to be reluctant at present to add existential intelligence to the list . . . . At most [he is] willing, Fellini-style, to joke about 8 intelligences (p. 127). I contend that research into entheogens and other means of altering consciousness will further support the case for treating existential intelligence as a valid cognitive domain.

By recapitulating and augmenting Gardners discussion of existential intelligence, I hope to have strengthened the case for its inclusion as a valid cognitive domain. However, doing so raises questions of what ramifications an acceptance of existential intelligence would have for contemporary Western educational theory and practice. How might we foster this hitherto neglected intelligence and allow it to be used in constructive ways? There is likely a range of educational practices that could be used to stimulate cognition in this domain, many of which could be readily implemented without much controversy.vi Yet I intentionally raise the prospect of using entheogens in this capacitynot with young children, but perhaps with older teens in the passage to adulthoodto challenge theorists, policy-makers and practitioners.vii

The potential of entheogens as tools for education in contemporary Western culture was identified by Aldous Huxley. Although better known as a novelist than as a philosopher of education, Huxley spent a considerable amount of timeparticularly as he neared the end of his lifeaddressing the topic of education. Like much of his literature, Huxleys observations and critiques of the socio-cultural forces at work in his time were cannily prescient; they bear as much, if not more, relevance in the 21st century as when they were written. Most remarkably, and relevant to my thesis, Huxley saw entheogens as possible educational tools:

Under the current dispensation the vast majority of individuals lose, in the course of education, all the openness to inspiration, all the capacity to be aware of other things than those enumerated in the Sears-Roebuck catalogue which constitutes the conventionally real world . . . . Is it too much to hope that a system of education may some day be devised, which shall give results, in terms of human development, commensurate with the time, money, energy and devotion expended? In such a system of education it may be that mescalin or some other chemical substance may play a part by making it possible for young people to taste and see what they have learned about at second hand . . . in the writings of the religious, or the works of poets, painters and musicians. (Letter to Dr. Humphrey Osmond, April 10th, 1953in Horowitz & Palmer, 1999, p.30)

In a more literary expression of this notion, Huxleys final novel Island (1962) portrays an ideal culture that has achieved a balance of scientific and spiritual thinking, and which also incorporates the ritualized use of entheogens for education. The representation of drug use that Huxley portrays in Island contrasts markedly with the more widely-known soma of his earlier novel, Brave New World (1932/1946): whereas soma was a pacifier that muted curiosity and served the interests of the controlling elite, the entheogenic moksha medicine of Island offered liminal experiences in young adults that stimulated profound reflection, self-actualization and, I submit, existential intelligence.

Huxleys writings point to an implicit recognition of the capacity of entheogens to be used as educational tools. The concept of tool here refers not merely the physical devices fashioned to aid material production, but, following Vygotsky (1978), more broadly to those means of symbolic and/or cultural mediation between the mind and the world (Cole, 1996; Wertsch, 1991). Of course, deriving educational benefit from a tool requires much more than simply having and wielding it; one must also have an intrinsic respect for the object qua tool, a cultural system in which the tool is valued as such, and guides or teachers who are adept at using the tool to provide helpful direction. As Larsen (1976) remarks in discussing the phenomenon of would-be shamans in Western culture experimenting with mind-altering chemicals: we have no symbolic vocabulary, no grounded mythological tradition to make our experiences comprehensible to us . . . no senior shamans to help ensure that our [shamanic experience of] dismemberment be followed by a rebirth (p. 81). Given the recent history of these substances in modern Western culture, it is hardly surprising that they have been demonized (Hofmann, 1980). However, cultural practices that have traditionally used entheogens as therapeutic agents consistently incorporate protective safeguardsset, settingviii, established dosages, and mythocultural respect (Zinberg, 1984). The fear that inevitably arises in modern Western culture when addressing the issue of entheogens stems, I submit, not from any properties intrinsic to the substances themselves, but rather from a general misunderstanding of their power and capacity as tools. Just as a sharp knife can be used for good or ill, depending on w
hether it is in the hands of a skilled surgeon or a reckless youth, so too can entheogens be used or misused.

The use of entheogens such as ayahuasca is exemplary of the long and ongoing tradition in many cultures to employ psychoactives as tools that stimulate foundational types of understanding (Tupper, in press). That such substances are capable of stimulating profoundly transcendent experiences is evident from both the academic literature and anecdotal reports. Accounting fully for their action, however, requires going beyond the usual explanatory schemas: applying Gardners (1999a) multiple intelligence theory as a heuristic framework opens new ways of understanding entheogens and their potential benefits. At the same time, entheogens bolster the case for Gardners proposed addition of existential intelligence. This article attempts to present these concepts in such a way that the possibility of using entheogens as tools is taken seriously by those with an interest in new and transformative ideas in education.

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Ruck, C., Bigwood, J., Staples, B., Ott, J., & Wasson, R. G. (1979). Entheogens. The Journal of Psychedelic Drugs. 11(1-2), 145-146.

Santo Daime. (2004). Santo Daime: The rainforests doctrine. Retrieved February 7th, 2004 from http://www.santodaime.org/indexy.htm

Schultes, R. E., & Hofmann, A. (1992). Plants of the gods: Their sacred, healing, and hallucinogenic powers. Rochester, VT: Healing Arts Press.

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Entheogens & Existential Intelligence: The Use of Plant ...

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nootropics / smart-drugs

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Sceptics about nootropics ("smart drugs") are unwitting victims of the so-called Panglossian paradigm of evolution. They believe that our cognitive architecture has been so fine-honed by natural selection that any tinkering with such a wonderfully all-adaptive suite of mechanisms is bound to do more harm than good. Certainly the notion that merely popping a pill could make you brighter sounds implausible. It sounds like the sort of journalistic excess that sits more comfortably in the pages of Fortean Times than any scholarly journal of repute.

Yet as Dean, Morgenthaler and Fowkes' (hereafter "DMF") book attests, the debunkers are wrong. On the one hand, numerous agents with anticholinergic properties are essentially dumb drugs. They impair memory, alertness, verbal facility and creative thought. Conversely, a variety of cholinergic drugs and nutrients, which form a large part of the smart-chemist's arsenal, can subtly but significantly enhance cognitive performance on a whole range of tests. This holds true for victims of Alzheimer's Disease, who suffer in particular from a progressive and disproportionate loss of cholinergic neurons. Yet, potentially at least, cognitive enhancers can aid non-demented people too. Members of the "normally" ageing population can benefit from an increased availability of acetylcholine, improved blood-flow to the brain, increased ATP production and enhanced oxygen and glucose uptake. Most recently, research with ampakines, modulators of neurotrophin-regulating AMPA-type glutamate receptors, suggests that designer nootropics will soon deliver sharper intellectual performance even to healthy young adults.

DMF provide updates from Smart Drugs (1) on piracetam, acetyl-l-carnitine, vasopressin, and several vitamin therapies. Smart Drugs II offers profiles of agents such as selegiline (l-deprenyl), melatonin, pregnenolone, DHEA and ondansetron (Zofran). There is also a provocative question-and-answer section; a discussion of product sources; and a guide to further reading.

So what's the catch? One problem, to which not all authorities on nootropics give enough emphasis, is the complex interplay between cognition and mood. Thus great care should be taken before tampering with the noradrenaline/acetylcholine axis. Thought-frenzied hypercholinergic states, for instance, are characteristic of one "noradrenergic" sub-type of depression. A predominance of forebrain cholinergic activity, frequently triggered by chronic uncontrolled stress, can lead to a reduced sensitivity to reward, an inability to sustain effort, and behavioural suppression.

This mood-modulating effect does make some sort of cruel genetic sense. Extreme intensity of reflective thought may function as an evolutionarily adaptive response when things go wrong. When they're going right, as in optimal states of "flow experience", we don't need to bother. Hence boosting cholinergic function, alone and in the absence of further pharmacologic intervention, can subdue mood. It can even induce depression in susceptible subjects. Likewise, beta-adrenergic antagonists (e.g. propranolol (Inderal)) can induce depression and fatigue. Conversely, "dumb-drug" anticholinergics may sometimes have mood-brightening - progressing to deliriant - effects. Indeed antimuscarinic agents acting in the nucleus accumbens may even induce a "mindless" euphoria.

Now it might seem axiomatic that helping everyone think more deeply is just what the doctor ordered. Yet our education system is already pervaded by an intellectual snobbery that exalts academic excellence over emotional well-being. In the modern era, examination rituals bordering on institutionalised child-abuse take a heavy toll on young lives. Depression and anxiety-disorders among young teens are endemic - and still rising. It's worth recalling that research laboratories routinely subject non-human animals to a regimen of "chronic mild uncontrolled stress" to induce depression in their captive animal population; investigators then test putative new antidepressants on the depressed animals to see if their despair can be experimentally reversed by patentable drugs. The "chronic mild stressors" that we standardly inflict on adolescent humans can have no less harmful effects on the mental health of captive school-students; but in this case, no organised effort is made to reverse it. Instead its victims often go on to self-medicate with ethyl alcohol, tobacco and street drugs. So arguably at least, the deformed and emotionally pre-literate minds churned out by our schools stand in need of safe, high-octane mood-brighteners more urgently than cognitive-tweakers. Memory-enhancers might be more worthwhile if we had more experiences worth remembering.

One possible solution to this dilemma involves taking a cholinergic agent such as piracetam (Nootropil) or aniracetam (Draganon, Ampamet) that also enhances dopamine function. Some researchers tentatively believe that the mesolimbic dopamine system acts as the final common pathway for pleasure in the brain. This hypothesis may well prove simplistic. There are certainly complications: it is not the neurotransmitter dopamine itself, but the post-synaptic metabolic cascades it triggers, that underlies motivated bliss. Other research suggests that it is the endogenous opioid system, and in particular activation of the mu opioid receptors, that mediates pure pleasure. Mesolimbic dopamine amplifies "incentive-motivation": "wanting" and "liking" may have different substrates, albeit intimately linked. Moreover there are mood-elevating memory-enhancers such as phosphodiesterase inhibitors (e.g. the selective PDE4 inhibitor rolipram) that act on different neural pathways - speeding and strengthening memory-formation by prolonging the availability of CREB. In any event, several of the most popular smart drugs discussed by DMF do indeed act on both the cholinergic and dopaminergic systems. In addition, agents like aniracetam and its analogs increase hippocampal glutaminergic activity. Hippocampal function is critical to memory - and mood. Thus newly developed ampakines, agents promoting long-term potentiation of AMPA-type glutamate receptors, are powerful memory-enhancers and future nootropics.

Another approach to enhancing mood and intellect alike involves swapping or combining a choline agonist with a different, primarily dopaminergic drug. Here admittedly there are methodological problems. The improved test score performances reported on so-called smart dopaminergics may have other explanations. Not all studies adequately exclude the confounding variables of increased alertness, sharper sensory acuity, greater motor activity or improved motivation - as distinct from any "pure" nootropic action. Yet the selective dopamine reuptake blocker amineptine (Survector) is both a mood-brightener and a possible smart-drug. Likewise selegiline, popularly known as l-deprenyl, has potentially life-enhancing properties. Selegiline is a selective, irreversible MAO-b inhibitor with antioxidant, immune-system-boosting and anti-neurodegenerative effects. It retards the metabolism not just of dopamine but also of phenylethylamine, a trace amine also found in chocolate and released when we're in love. Selegiline also stimulates the release of superoxide dismutase (SOD); SOD is a key enzyme which helps to quench damaging free-radicals. Taken consistently in low doses, selegiline extends the life-expectancy of rats by some 20%; enhances drive, libido and endurance; and independently improves cognitive performance in Alzheimer's pa
tients and in some healthy normals. It is used successfully to treat canine cognitive dysfunction syndrome (CDS) in dogs. In 2006, higher dose (i.e. less MAO-b selective) selegiline was licensed as the antidepressant EMSAM, a transdermal patch. Selegiline also protects the brain's dopamine cells from oxidative stress. The brain has only about 30-40 thousand dopaminergic neurons in all. It tends to lose perhaps 13% a decade in adult life. An eventual 70%-80% loss leads to the dopamine-deficiency disorder Parkinson's disease and frequently depression. Clearly anything that spares so precious a resource might prove a valuable tool for life-enrichment.

In 2005, a second selective MAO-b inhibitor, rasagiline (Azilect) gained an EC product license. Its introduction was followed a year later in the USA. Unlike selegiline, rasagiline doesn't have amphetamine trace metabolites - a distinct if modest therapeutic advantage.

Looking further ahead, the bifunctional cholinesterase inhibitor and MAO-b inhibitor ladostigil acts both as a cognitive enhancer and a mood brightener. Ladostigil has neuroprotective and potential antiaging properties too. Its product-license is several years away at best.

Consider, for instance, the plight of genetically engineered "smart mice" endowed with an extra copy of the NR2B subtype of NMDA receptor. It is now known that such brainy "Doogie" mice suffer from a chronically increased sensitivity to pain. Memory-enhancing drugs and potential gene-therapies targeting the same receptor subtype might cause equally disturbing side-effects in humans. Conversely, NMDA antagonists like the dissociative anaesthetic drug ketamine exert amnestic, antidepressant and analgesic effects in humans and non-humans alike.

Amplified memory can itself be a mixed blessing. Even among the drug-nave and chronically forgetful, all kinds of embarrassing, intrusive and traumatic memories may haunt our lives. Such memories sometimes persist for months, years or even decades afterwards. Unpleasant memories can sour the well-being even of people who don't suffer from clinical PTSD. The effects of using all-round memory enhancers might do something worse than merely fill our heads with clutter. Such agents could etch traumatic experiences more indelibly into our memories. Or worse, such all-round enhancers might promote the involuntary recall of our nastiest memories with truly nightmarish intensity.

By contrast, the design of chemical tools that empower us selectively to forget unpleasant memories may prove to be at least as life-enriching as agents that help us remember more effectively. Unlike the software of digital computers, human memories can't be specifically deleted to order. But this design-limitation may soon be overcome. The synthesis of enhanced versions of protease inhibitors such as anisomycin may enable us selectively to erase horrible memories. If such agents can be refined for our personal medicine cabinets, then we'll potentially be able to rid ourselves of nasty or unwanted memories at will - as distinct from drowning our sorrows with alcohol or indiscriminately dulling our wits with tranquillisers. In future, the twin availability of 1] technologies to amplify desirable memories, and 2] selective amnestics to extinguish undesirable memories, promises to improve our quality of life far more dramatically than use of today's lame smart drugs.

Such a utopian pharmaceutical toolkit is still some way off. Given our current primitive state of knowledge, it's hard to boost the function of one neurotransmitter signalling system or receptor sub-type without eliciting compensatory and often unwanted responses from others. Life's successful, dopamine-driven go-getters, for instance, whether naturally propelled or otherwise, may be highly productive individuals. Yet they are rarely warm, relaxed and socially empathetic. This is because, crudely, dopamine overdrive tends to impair "civilising serotonin" function. Unfortunately, tests of putative smart drugs typically reflect an impoverished and culture-bound conception of intelligence. Indeed today's "high IQ" alpha males may strike posterity as more akin to idiot savants than imposing intellectual giants. IQ tests, and all conventional scholastic examinations, neglect creative and practical intelligence. They simply ignore social cognition. Social intelligence, and its cognate notion of "emotional IQ", isn't some second-rate substitute for people who can't do IQ tests. On the contrary, according to the Machiavellian ape hypothesis, the evolution of human intelligence has been driven by our superior "mind-reading" skills. Higher-order intentionality [e.g. "you believe that I hope that she thinks that I want...", etc] is central to the lives of advanced social beings. The unique development of human mind is an adaptation to social problem-solving and the selective advantages it brings. Yet pharmaceuticals that enhance our capacity for empathy, enrich our social skills, expand our "state-space" of experience, or deepen our introspective self-knowledge are not conventional candidates for smart drugs. For such faculties don't reflect our traditional [male] scientific value-judgements on what qualifies as "intelligence". Thus in academia, for instance, competitive dominance behaviour among "alpha" male human primates often masquerades as the pursuit of scholarship. Emotional literacy is certainly harder to quantify scientifically than mathematical puzzle-solving ability or performance in verbal memory-tests. But to misquote Robert McNamara, we need to stop making what is measurable important, and find ways to make the important measurable. By some criteria, contemporary IQ tests are better measures of high-grade autism than mature intelligence. So before chemically manipulating one's mind, it's worth critically examining which capacities one wants to enhance; and to what end?

In practice, the first and most boring advice is often the most important. Many potential users of smart pills would be better and more simply advised to stop taking tranquillisers, sleeping tablets or toxic recreational drugs; eat omega-3 rich foods, more vegetables and generally improve their diet; and try more mentally challenging tasks. One of the easiest ways of improving memory, for instance, is to increase the flow of oxygenated blood to the brain. This can be achieved by running, swimming, dancing, brisk walking, and more sex. Regular vigorous exercise also promotes nerve cell growth in the hippocampus. Hippocampal brain cell growth potentially enhances mood, memory and cognitive vitality alike. Intellectuals are prone to echo J.S. Mill: "Better to be an unhappy Socrates than a happy pig". But happiness is typically good for the hippocampus; by contrast, the reduced hippocampal volume anatomically characteristic of depressives correlates with the length of their depression.

In our current state of ignorance, homely remedies are still sometimes best. Thus moderate consumption of adenosine-inhibiting, common-or-garden caffeine improves concentration, mood and alertness; enhances acetylcholine release in the hippocampus; and statistically reduces the risk of suicide. Regular coffee drinking induces competitive and reversible inhibition of MAO enzymes type A and B owing to coffee's neuroactive beta-carbolines. Coffee is also rich in antioxidants. Non-coffee drinkers are around three times more likely to contract Parkinson's disease. A Michigan study found caffeine use was correlated with enhanced male virility in later life.

Before resorting to pills, aspiri
ng intellectual heavyweights might do well to start the day with a low-fat/high carbohydrate breakfast: muesli rather than tasty well-buttered croissants. This will enhance memory, energy and blood glucose levels. An omega-3 rich diet will enhance all-round emotional and intellectual health too. A large greasy fry-up, on the other hand, can easily leave one feeling muddle-headed, drowsy and lethargic. If one wants to stay sharp, and to blunt the normal mid-afternoon dip, then eating big fatty lunches isn't a good idea either. Fat releases cholecystokinin (CCK) from the duodenum. Modest intravenous infusions of CCK make one demonstrably dopey and subdued.

To urge such caveats is not to throw up one's hands in defeatist resignation. Creative psychopharmacology can often in principle circumvent such problems, even today. Complementary and sometimes effective combinations such as sustained-release methylphenidate (Ritalin) and SSRIs such as fluoxetine (Prozac), for instance, are arguably still under-used. They could be more widely applied both in clinical psychiatry and, at least in the context of a general harm-reduction strategy, on the street. There may indeed be no safe drugs but just safe dosages. Yet some smart drugs, such as piracetam, really do seem to be at worst pretty innocuous. Agents such as the alpha-1 adrenergic agonist adrafinil (Olmifron) typically do have both mood-brightening and intellectually invigorating effects. Adrafinil, like its chemical cousin modafinil (Provigil), promotes alertness, vigilance and mental focus; and its more-or-less pure CNS action ensures it doesn't cause unwanted peripheral sympathetic stimulation.

Unfortunately the lay public is currently ill-served, a few shining exceptions aside, by the professionals. A condition of ignorance and dependence is actively fostered where it isn't just connived at in the wider population. So there's often relatively little point in advising anyone contemplating acting on DMF's book to consult their physician first. For it's likely their physician won't want to know, or want them to know, in the first instance.

As traditional forms of censorship, news-management and governmental information-control break down, however, and the Net insinuates itself into ever more areas of daily life, more and more people are stumbling upon - initially - and then exploring, the variety of drugs and combination therapies which leading-edge pharmaceutical research puts on offer. They are increasingly doing so as customers, and not as patronisingly labelled role-bound "patients". Those outside the charmed circle have previously been cast in the obligatory role of humble supplicants. The more jaundiced or libertarian among the excluded may have felt themselves at the mercy of prescription-wielding, or -withholding, agents of one arm of the licensed drug cartels. So when the control of the cartels and their agents falters, there is an especially urgent need for incisive and high-quality information to be made readily accessible. Do DMF fulfil it?

Smart Drugs 2 lays itself wide open to criticism; but then it takes on an impossible task. In the perennial trade-off between accessibility and scholarly rigour, compromises are made on both sides. Ritual disclaimers aside, DMF's tone can at times seem too uncritically gung-ho. Their drug-profiles and cited studies don't always give due weight to the variations in sample size and the quality of controls. Nor do they highlight the uncertain calibre of the scholarly journals in which some of the most interesting results are published. DMFs inclusion of anecdote-studded personal testimonials is almost calculated to inflame medical orthodoxy. Moreover it should be stressed that the scientific gold-standard of large, placebo-controlled, double-blind cross-over prospective trials are still quite rare in this field as a whole.

Looking ahead, this century's mood-boosting, intellect-sharpening, empathy-enhancing and personality-enriching drugs are themselves likely to prove only stopgaps. This is because invincible, life-long happiness and supergenius intellect may one day be genetically pre-programmed and possibly ubiquitous in our transhuman successors. Taking drugs to repair Nature's deficiencies may eventually become redundant. Memory- and intelligence-boosting gene therapies are already imminent. But in repairing the deficiencies of an educational system geared to producing dysthymic pharmacological illiterates, Smart Drugs 1 and 2 offers a warmly welcome start.

Refs and further reading

HedWeb Future Opioids BLTC Research Superhappiness? Utopian Surgery? Social Media 2015 Nutritional Medicine Wirehead Hedonism The Good Drug Guide The Abolitionist Project Reproductive Revolution Critique Of Brave New World MDMA: Utopian Pharmacology Nootropics/Smart Drugs: Sources The Biointelligence Explosion (2013) Male intelligence vs female intelligence Humans and AI: Co-evolution, Fusion or Replacement? (2013) e-mail info@nootropics.com

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nootropics / smart-drugs

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Neurotechnology – Wikipedia, the free encyclopedia

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Neurotechnology is any technology that has a fundamental influence on how people understand the brain and various aspects of consciousness, thought, and higher order activities in the brain. It also includes technologies that are designed to improve and repair brain function and allow researchers and clinicians to visualize the brain.

The field of neurotechnology has been around for nearly half a century but has only reached maturity in the last twenty years. The advent of brain imaging revolutionized the field, allowing researchers to directly monitor the brains activities during experiments. Neurotechnology has made significant impact on society, though its presence is so commonplace that many do not realize its ubiquity. From pharmaceutical drugs to brain scanning, neurotechnology affects nearly all industrialized people either directly or indirectly, be it from drugs for depression, sleep, ADD, or anti-neurotics to cancer scanning, stroke rehabilitation, and much more.

As the fields depth increases it will potentially allow society to control and harness more of what the brain does and how it influences lifestyles and personalities. Commonplace technologies already attempt to do this; games like BrainAge,[1] and programs like Fast ForWord[2] that aim to improve brain function, are neurotechnologies.

Currently, modern science can image nearly all aspects of the brain as well as control a degree of the function of the brain. It can help control depression, over-activation, sleep deprivation, and many other conditions. Therapeutically it can help improve stroke victims motor coordination, improve brain function, reduce epileptic episodes (see epilepsy), improve patients with degenerative motor diseases (Parkinson's disease, Huntingtons Disease, ALS), and can even help alleviate phantom pain perception.[3] Advances in the field promise many new enhancements and rehabilitation methods for patients suffering from neurological problems. The neurotechnology revolution has given rise to the Decade of the Mind initiative, which was started in 2007.[4] It also offers the possibility of revealing the mechanisms by which mind and consciousness emerge from the brain.

Magnetoencephalography is a functional neuroimaging technique for mapping brain activity by recording magnetic fields produced by electrical currents occurring naturally in the brain, using very sensitive magnetometers. Arrays of SQUIDs (superconducting quantum interference devices) are the most common magnetometer. Applications of MEG include basic research into perceptual and cognitive brain processes, localizing regions affected by pathology before surgical removal, determining the function of various parts of the brain, and neurofeedback. This can be applied in a clinical setting to find locations of abnormalities as well as in an experimental setting to simply measure brain activity.[5]

Magnetic resonance imaging (MRI) is used for scanning the brain for topological and landmark structure in the brain, but can also be used for imaging activation in the brain.[6] While detail about how MRI works is reserved for the actual MRI article, the uses of MRI are far reaching in the study of neuroscience. It is a cornerstone technology in studying the mind, especially with the advent of functional MRI (fMRI).[7] Functional MRI measures the oxygen levels in the brain upon activation (higher oxygen content = neural activation) and allows researchers to understand what loci are responsible for activation under a given stimulus. This technology is a large improvement to single cell or loci activation by means of exposing the brain and contact stimulation. Functional MRI allows researchers to draw associative relationships between different loci and regions of the brain and provides a large amount of knowledge in establishing new landmarks and loci in the brain.[8]

Computed tomography (CT) is another technology used for scanning the brain. It has been used since the 1970s and is another tool used by neuroscientists to track brain structure and activation.[6] While many of the functions of CT scans are now done using MRI, CT can still be used as the mode by which brain activation and brain injury are detected. Using an X-ray, researchers can detect radioactive markers in the brain that indicate brain activation as a tool to establish relationships in the brain as well as detect many injuries/diseases that can cause lasting damage to the brain such as aneurysms, degeneration, and cancer.

Positron emission tomography (PET) is another imaging technology that aids researchers. Instead of using magnetic resonance or X-rays, PET scans rely on positron emitting markers that are bound to a biologically relevant marker such as glucose.[9] The more activation in the brain the more that region requires nutrients, so higher activation appears more brightly on an image of the brain. PET scans are becoming more frequently used by researchers because PET scans are activated due to metabolism whereas MRI is activated on a more physiological basis (sugar activation versus oxygen activation).

Transcranial magnetic stimulation (TMS) is essentially direct magnetic stimulation to the brain. Because electric currents and magnetic fields are intrinsically related, by stimulating the brain with magnetic pulses it is possible to interfere with specific loci in the brain to produce a predictable effect.[10] This field of study is currently receiving a large amount of attention due to the potential benefits that could come out of better understanding this technology.[11] Transcranial magnetic movement of particles in the brain shows promise for drug targeting and delivery as studies have demonstrated this to be noninvasive on brain physiology.[12]

Transcranial direct current stimulation (tDCS) is a form of neurostimulation which uses constant, low current delivered via electrodes placed on the scalp. The mechanisms underlying tDCS effects are still incompletely understood, but recent advances in neurotechnology allowing for in vivo assessment of brain electric activity during tDCS[13] promise to advance understanding of these mechanisms. Research into using tDCS on healthy adults have demonstrated that tDCS can increase cognitive performance on a variety of tasks, depending on the area of the brain being stimulated. tDCS has been used to enhance language and mathematical ability (though one form of tDCS was also found to inhibit math learning),[14] attention span, problem solving, memory,[15] and coordination.

Electroencephalography (EEG) is a method of measuring brainwave activity non-invasively. A number of electrodes are placed around the head and scalp and electrical signals are measured. Typically EEGs are used when dealing with sleep, as there are characteristic wave patterns associated with different stages of sleep.[16] Clinically EEGs are used to study epilepsy as well as stroke and tumor presence in the brain. EEGs are a different method to understand the electrical signaling in the brain during activation.

Magnetoencephalography (MEG) is another method of measuring activity in the brain by measuring the magnetic fields that arise from electrical currents in the brain.[17] The benefit to using MEG instead of EEG is that these fields are highly localized and give rise to better understanding of how specific loci react to stimulation or if these regions over-activate (as in epileptic seizures).

Neurodevices are any devices used to monitor or regulate brain activity. Currently there are a few available for clinical use as a treatment for Parkinsons disease
. The most common neurodevices are deep brain stimulators (DBS) that are used to give electrical stimulation to areas stricken by inactivity.[18] Parkinsons disease is known to be caused by an inactivation of the basal ganglia (nuclei) and recently DBS has become the more preferred form of treatment for Parkinsons disease, although current research questions the efficiency of DBS for movement disorders.[18]

Neuromodulation is a relatively new field that combines the use of neurodevices and neurochemistry. The basis of this field is that the brain can be regulated using a number of different factors (metabolic, electrical stimulation, physiological) and that all these can be modulated by devices implanted in the neural network. While currently this field is still in the researcher phase, it represents a new type of technological integration in the field of neurotechnology. The brain is a very sensitive organ, so in addition to researching the amazing things that neuromodulation and implanted neural devices can produce, it is important to research ways to create devices that elicit as few negative responses from the body as possible. This can be done by modifying the material surface chemistry of neural implants.

Researchers have begun looking at uses for stem cells in the brain, which recently have been found in a few loci. A large number of studies[citation needed] are being done to determine if this form of therapy could be used in a large scale. Experiments have successfully used stem cells in the brains of children who suffered from injuries in gestation and elderly people with degenerative diseases in order to induce the brain to produce new cells and to make more connections between neurons.

Pharmaceuticals play a vital role in maintaining stable brain chemistry, and are the most commonly used neurotechnology by the general public and medicine. Drugs like sertraline, methylphenidate, and zolpidem act as chemical modulators in the brain, and they allow for normal activity in many people whose brains cannot act normally under physiological conditions. While pharmaceuticals are usually not mentioned and have their own field, the role of pharmaceuticals is perhaps the most far-reaching and commonplace in modern society (the focus on this article will largely ignore neuropharmaceuticals, for more information, see neuropsychopharmacology). Movement of magnetic particles to targeted brain regions for drug delivery is an emerging field of study and causes no detectable circuit damage.[19]

Stimulation with low-intensity magnetic fields is currently under study for depression at Harvard Medical School, and has previously been explored by Bell (et al.),[20] Marino (et al.),[21] and others.

Magnetic resonance imaging is a vital tool in neurological research in showing activation in the brain as well as providing a comprehensive image of the brain being studied. While MRIs are used clinically for showing brain size, it still has relevance in the study of brains because it can be used to determine extent of injuries or deformation. These can have a significant effect on personality, sense perception, memory, higher order thinking, movement, and spatial understanding. However, current research tends to focus more so on fMRI or real-time functional MRI (rtfMRI).[22] These two methods allow the scientist or the participant, respectively, to view activation in the brain. This is incredibly vital in understanding how a person thinks and how their brain reacts to a persons environment, as well as understanding how the brain works under various stressors or dysfunctions. Real-time functional MRI is a revolutionary tool available to neurologists and neuroscientists because patients can see how their brain reacts to stressors and can perceive visual feedback.[8] CT scans are very similar to MRI in their academic use because they can be used to image the brain upon injury, but they are more limited in perceptual feedback.[6] CTs are generally used in clinical studies far more than in academic studies, and are found far more often in a hospital than a research facility. PET scans are also finding more relevance in academia because they can be used to observe metabolic uptake of neurons, giving researchers a wider perspective about neural activity in the brain for a given condition.[9] Combinations of these methods can provide researchers with knowledge of both physiological and metabolic behaviors of loci in the brain and can be used to explain activation and deactivation of parts of the brain under specific conditions.

Transcranial magnetic stimulation is a relatively new method of studying how the brain functions and is used in many research labs focused on behavioral disorders and hallucinations. What makes TMS research so interesting in the neuroscience community is that it can target specific regions of the brain and shut them down or activate temporarily; thereby changing the way the brain behaves. Personality disorders can stem from a variety of external factors, but when the disorder stems from the circuitry of the brain TMS can be used to deactivate the circuitry. This can give rise to a number of responses, ranging from normality to something more unexpected, but current research is based on the theory that use of TMS could radically change treatment and perhaps act as a cure for personality disorders and hallucinations.[11] Currently, repetitive transcranial magnetic stimulation (rTMS) is being researched to see if this deactivation effect can be made more permanent in patients suffering from these disorders. Some techniques combine TMS and another scanning method such as EEG to get additional information about brain activity such as cortical response.[23]

Both EEG and MEG are currently being used to study the brains activity under different conditions. Each uses similar principles but allows researchers to examine individual regions of the brain, allowing isolation and potentially specific classification of active regions. As mentioned above, EEG is very useful in analysis of immobile patients, typically during the sleep cycle. While there are other types of research that utilize EEG,[23] EEG has been fundamental in understanding the resting brain during sleep.[16] There are other potential uses for EEG and MEG such as charting rehabilitation and improvement after trauma as well as testing neural conductivity in specific regions of epileptics or patients with personality disorders.

Neuromodulation can involve numerous technologies combined or used independently to achieve a desired effect in the brain. Gene and cell therapy are becoming more prevalent in research and clinical trials and these technologies could help stunt or even reverse disease progression in the central nervous system. Deep brain stimulation is currently used in many patients with movement disorders and is used to improve the quality of life in patients.[18] While deep brain stimulation is a method to study how the brain functions per se, it provides both surgeons and neurologists important information about how the brain works when certain small regions of the basal ganglia (nuclei) are stimulated by electrical currents.

The future of neurotechnologies lies in how they are fundamentally applied, and not so much on what new versions will be developed. Current technologies give a large amount of insight into the mind and how the brain functions, but basic research is still needed to demonstrate the more applied functions of these technologies. Currently, rtfMRI is being researched as a method for pain therapy. deCharms et al. have shown that there is a significant improvement in the way people pe
rceive pain if they are made aware of how their brain is functioning while in pain. By providing direct and understandable feedback, researchers can help patients with chronic pain decrease their symptoms. This new type of bio/mechanical-feedback is a new development in pain therapy.[8] Functional MRI is also being considered for a number of more applicable uses outside of the clinic. Research has been done on testing the efficiency of mapping the brain in the case when someone lies as a new way to detect lying.[24] Along the same vein, EEG has been considered for use in lie detection as well.[25] TMS is being used in a variety of potential therapies for patients with personality disorders, epilepsy, PTSD, migraine, and other brain-firing disorders, but has been found to have varying clinical success for each condition.[11] The end result of such research would be to develop a method to alter the brains perception and firing and train patients brains to rewire permanently under inhibiting conditions (for more information see rTMS).[11] In addition, PET scans have been found to be 93% accurate in detecting Alzheimer's disease nearly 3 years before conventional diagnosis, indicating that PET scanning is becoming more useful in both the laboratory and the clinic.[26]

Stem cell technologies are always salient both in the minds of the general public and scientists because of their large potential. Recent advances in stem cell research have allowed researchers to ethically pursue studies in nearly every facet of the body, which includes the brain. Research has shown that while most of the brain does not regenerate and is typically a very difficult environment to foster regeneration,[27] there are portions of the brain with regenerative capabilities (specifically the hippocampus and the olfactory bulbs).[28] Much of the research in central nervous system regeneration is how to overcome this poor regenerative quality of the brain. It is important to note that there are therapies that improve cognition and increase the amount of neural pathways,[2] but this does not mean that there is a proliferation of neural cells in the brain. Rather, it is called a plastic rewiring of the brain (plastic because it indicates malleability) and is considered a vital part of growth. Nevertheless, many problems in patients stem from death of neurons in the brain, and researchers in the field are striving to produce technologies that enable regeneration in patients with stroke, Parkinsons diseases, severe trauma, and Alzheimer's disease, as well as many others. While still in fledgling stages of development, researchers have recently begun making very interesting progress in attempting to treat these diseases. Researchers have recently successfully produced dopaminergic neurons for transplant in patients with Parkinsons diseases with the hopes that they will be able to move again with a more steady supply of dopamine.[29][not in citation given] Many researchers are building scaffolds that could be transplanted into a patient with spinal cord trauma to present an environment that promotes growth of axons (portions of the cell attributed with transmission of electrical signals) so that patients unable to move or feel might be able to do so again.[30] The potentials are wide-ranging, but it is important to note that many of these therapies are still in the laboratory phase and are slowly being adapted in the clinic.[31] Some scientists remain skeptical with the development of the field, and warn that there is a much larger chance that electrical prosthesis will be developed to solve clinical problems such as hearing loss or paralysis before cell therapy is used in a clinic.[32][need quotation to verify]

Novel drug delivery systems are being researched in order to improve the lives of those who struggle with brain disorders that might not be treated with stem cells, modulation, or rehabilitation. Pharmaceuticals play a very important role in society, and the brain has a very selective barrier that prevents some drugs from going from the blood to the brain. There are some diseases of the brain such as meningitis that require doctors to directly inject medicine into the spinal cord because the drug cannot cross the bloodbrain barrier.[33] Research is being conducted to investigate new methods of targeting the brain using the blood supply, as it is much easier to inject into the blood than the spine. New technologies such as nanotechnology are being researched for selective drug delivery, but these technologies have problems as with any other. One of the major setbacks is that when a particle is too large, the patients liver will take up the particle and degrade it for excretion, but if the particle is too small there will not be enough drug in the particle to take effect.[34] In addition, the size of the capillary pore is important because too large a particle might not fit or even plug up the hole, preventing adequate supply of the drug to the brain.[34] Other research is involved in integrating a protein device between the layers to create a free-flowing gate that is unimpeded by the limitations of the body. Another direction is receptor-mediated transport, where receptors in the brain used to transport nutrients are manipulated to transport drugs across the bloodbrain barrier.[35] Some have even suggested that focused ultrasound opens the bloodbrain barrier momentarily and allows free passage of chemicals into the brain.[36] Ultimately the goal for drug delivery is to develop a method that maximizes the amount of drug in the loci with as little degraded in the blood stream as possible.

Neuromodulation is a technology currently used for patients with movement disorders, although research is currently being done to apply this technology to other disorders. Recently, a study was done on if DBS could improve depression with positive results, indicating that this technology might have potential as a therapy for multiple disorders in the brain.[32][need quotation to verify] DBS is limited by its high cost however, and in developing countries the availability of DBS is very limited.[18] A new version of DBS is under investigation and has developed into the novel field, optogenetics.[31] Optogenetics is the combination of deep brain stimulation with fiber optics and gene therapy. Essentially, the fiber optic cables are designed to light up under electrical stimulation, and a protein would be added to a neuron via gene therapy to excite it under light stimuli.[37] So by combining these three independent fields, a surgeon could excite a single and specific neuron in order to help treat a patient with some disorder. Neuromodulation offers a wide degree of therapy for many patients, but due to the nature of the disorders it is currently used to treat its effects are often temporary. Future goals in the field hope to alleviate that problem by increasing the years of effect until DBS can be used for the remainder of the patients life. Another use for neuromodulation would be in building neuro-interface prosthetic devices that would allow quadriplegics the ability to maneuver a cursor on a screen with their thoughts, thereby increasing their ability to interact with others around them. By understanding the motor cortex and understanding how the brain signals motion, it is possible to emulate this response on a computer screen.[38]

The ethical debate about use of embryonic stem cells has stirred controversy both in the United States and abroad; although more recently these debates have lessened due to modern advances in creating induced pluripotent stem cells from adult cells. The greatest advantage for use of embryonic stem cells is the fa
ct that they can differentiate (become) nearly any type of cell provided the right conditions and signals. However, recent advances by Shinya Yamanaka et al. have found ways to create pluripotent cells without the use of such controversial cell cultures.[39] Using the patients own cells and re-differentiating them into the desired cell type bypasses both possible patient rejection of the embryonic stem cells and any ethical concerns associated with using them, while also providing researchers a larger supply of available cells. However, induced pluripotent cells have the potential to form benign (though potentially malignant) tumors, and tend to have poor survivability in vivo (in the living body) on damaged tissue.[40] Much of the ethics concerning use of stem cells has subsided from the embryonic/adult stem cell debate due to its rendered moot, but now societies find themselves debating whether or not this technology can be ethically used. Enhancements of traits, use of animals for tissue scaffolding, and even arguments for moral degeneration have been made with the fears that if this technology reaches its full potential a new paradigm shift will occur in human behavior.

New neurotechnologies have always garnered the appeal of governments, from lie detection technology and virtual reality to rehabilitation and understanding the psyche. Due to the Iraq War and War on Terror, American soldiers coming back from Iraq and Afghanistan are reported to have percentages up to 12% with PTSD.[41] There are many researchers hoping to improve these peoples conditions by implementing new strategies for recovery. By combining pharmaceuticals and neurotechnologies, some researchers have discovered ways of lowering the "fear" response and theorize that it may be applicable to PTSD.[42] Virtual reality is another technology that has drawn much attention in the military. If improved, it could be possible to train soldiers how to deal with complex situations in times of peace, in order to better prepare and train a modern army.

Finally, when these technologies are being developed society must understand that these neurotechnologies could reveal the one thing that people can always keep secret: what they are thinking. While there are large amounts of benefits associated with these technologies, it is necessary for scientists and policy makers alike to consider implications about cognitive liberty.[43] This term is important in many ethical circles concerned with the state and goals of progress in the field of neurotechnology (see Neuroethics). Current improvements such as brain fingerprinting or lie detection using EEG or fMRI could give rise to a set fixture of loci/emotional relationships in the brain, although these technologies are still years away from full application.[43] It is important to consider how all these neurotechnologies might affect the future of society, and it is suggested that political, scientific, and civil debates are heard about the implementation of these newer technologies that potentially offer a new wealth of once-private information.[43] Some ethicists are also concerned with the use of TMS and fear that the technique could be used to alter patients in ways that are undesired by the patient.[11]

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Neurotechnology - Wikipedia, the free encyclopedia

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7: Mass Data – 10 Futurist Predictions in the World of …

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Even if scientists and marketers can't get access to our brains for neurohacking or neuromarketing, can they get access to our data? With unprecedented amounts of images and data available online, filling clouds and other Web-based storage, media, government regulatory bodies and marketers work around the clock to mine user preferences, habits and even relationships.

What to do with all of this data, and more specifically and maybe more urgently, how can we keep all of our activities in the virtual space from shaping the real space of our world? As search preferences narrow results when using the Internet, and our reading and research have become "optimized" based on what key words people search for, our choices in buying products and accessing news and information narrows as the enormous stores of data accumulate.

Data and the machines and algorithms used to manage and make sense of it could largely replace independent decision-making -- either large or small -- and it is happening at such a speed that it's sometimes hard to remember the data isn't in control. People still control the data, but just who has this control and what they do with it will become an ongoing challenge [source: Seligson; IGF].

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7: Mass Data - 10 Futurist Predictions in the World of ...

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