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Where To Find Pumpkin Patches, Halloween Fun Near Banning, Beaumont – Patch

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INLAND EMPIRE, CA Grab your calendars, and get ready for fall festivities!

Halloween and autumn events abound throughout the Inland Empire. Peruse Patch's annual guide to find haunted houses, Dia de los Muertos extravaganzas, trick-or-treating, costume parties, corn mazes, pumpkin patches and more near you.

Enjoy the season and Happy Halloween from Patch!

OCT. 29: Halloween Spooktacular Trunk-Or-Treat: Community Center. "Come by and fill your bags with treats! "

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OCT. 15: Monster Mash Halloween Party & Costume Contest. Featuring free games, candy, reptile exhibit, bouncers, rock climbing & costume contest.

OCT. 31: Halloween Trunk-Or-Treat: Sports Park. Don't forget your costumes!

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OCT. 30: Halloween Spooktacular & Trick-or-Treating. Costume contest, too!

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OCT. 1-31: 'Pumpkin Factory' Pumpkin Patch, Rides & Petting Zoo. With amusement rides for little ones.

OCT. 7-30: Coffin Creek Haunted Village. "Five haunted attractions & Dark Shadow Market Place at one terrifying location."

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OCT. 22: A Very Bizzy Halloween Family Fest & Costume Ball: Bizzyland Gardens. Family-friendly by day & for 21+ by night.-----------

OCT. 1-30: 'Dimensions of Insanity: Torture' - Immersive Haunt Experience. "A nightmarish experience you wish were just a dream."

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OCT. 28-30: Halloween 'Boo At The Bowl': Ramona Bowl Amphitheatre. Get pre-sale or at-the-door tickets for this annual event.

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OCT. 29: Bat Walk Night Adventure in La Quinta Cove. "The best superhero bat costume gets a prize!"-----------

OCT. 15: Bracken Fern Manor & Tudor House Lockdown: Paranormal Investigation. For the super brave, there's a blindfolded, solitary challenge, too.

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SEPT. 24-OCT. 31: ABC Pumpkin Patch - Bounce House, Rides & Giant Slide. Choose a pumpkin & stay for the fun.

SEPT. 30-OCT. 30: 'Undead Circus' Haunted Maze & Carnival, Launch Pointe. The carnival portion is family-friendly with games, pumpkins & bounce houses.

OCT.: Field Of Screams The Haunted Stadium: Canceled for 2022.

OCT. 15: Mariachi Fest & Fireworks: Diamond Stadium. Award-wining performances followed by fireworks finale.

OCT. 28: Halloween Costume Party. With two DJs, food & costume contest. 18+ to party, & 21+ to drink.

OCT. 28-30: Storm Halloween Fest, Carnival Rides & Marketplace. Midway features Ferris wheel, wave slide, kiddie rides & more.

OCT. 29: Dia De Los Muertos Celebration: Main Street. Featuring music & dance, artists, vendors, crafts for kids, food & altars.

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OCT. 5, 12, 19, 26 & 31: 'Hitchcocktober' Halloween Movie Fest: Reading Cinemas Cal Oaks. It's the perfect season to enjoy films of Alfred Hitchcock, the master of suspense.

OCT. 29: Trunk-Or-Treat & 'Ghostbusters' Movie. Free for all at Town Square Park.----------

SEPT. 23-OCT. 29: 'Legend Of Sleepy Hollow': Riley's Farm Theatre Co. Book soon if interested. This beloved, annual event sells fast.------------

SEPT. 30 - OCT. 31: Miss Hazel's Parkwil Manor Haunted House: Shops At Palm Desert. The "deadicated" cast takes scary seriously. At former Westfield Palm Desert.

OCT. 29: The Amazing World of Bats. RSVP as space is limited.

OCT. 29-30: Howl-O-Ween & Trick-or-Treating: Living Desert Zoo. With animal fun & magician, too.

OCT. 30: 'Masquerade' Golf Cart Parade & Halloween Fun. NFL legend & recent Pro Football Hall of Fame Inductee, Tom Flores, is Grand Marshal, and this years theme is "Masquerade."-----------

OCT. 28, 29 & 31: 'BITE' Vampire Circus Dining Adventure: PS Underground. With "free-flowing blood-curdling cocktails, beer, wine, hand-passed appetizers & diabolical four-course dinner."OCT. 30: Boys & Girls Club 'Be A Hero For Kids Halloween Bash': Hilton Palm Springs. All proceeds support the organization.

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OCT. 29: 'The Bride Of Pinacate' Haunted Train Ride: SoCal Railway Museum. A young, widowed bride has haunted the tracks for 135 years. All aboard to discover her secrets!

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SEPT. 16-OCT. 31: Live Oak Canyon Pumpkin Patch, Corn Maze & Petting Zoo. Extravaganza includes hay rides, weekend entertainment, rope courses, zip line, duck races & more.

OCT. 22: 'Hollywood Halloween' Trick-Or-Treat Event: Citrus Plaza. With costume parade, petting zoo, face painting & Famous Dave's BBQ lunch.

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SEPT. 23-OCT. 30: 'Castle Dark' Halloween Haunts: Castle Park. Fright-filled mazes are what happens when your neighborhood mini-golf, amusement park lets ghouls visit on weekends.

SEPT. 24-OCT. 30: Dia De Los Muertos & Trick-Or-Treating: Castle Park. Weekend fun with Mexican & Latin American traditions, decorations, music, marionettes and treats.

OCT. 21-22: 'CarnEVIL' - California Riverside Ballet Ghost Walk & Festival. Experience ends at kids carnival, food & vendor court & Tavern of Terror beer garden.-----------

NOV. 5: Annual 'Autumn Elegance' Wine & Food Fundraiser: Soboba Casino. Annual fall event to benefit Hemet-San Jacinto Exchange Club & Friends of Valley-Wide Foundation.-----------

SEPT. 24-OCT. 31: Peltzer Pumpkin Patch & Petting Farm. A community tradition in its 26th season!

SEPT. 30-OCT. 31: 'Mansion Of Lost Souls' Halloween Haunt: Promenade Mall. "We cannot promise that you all will make it through, but we will pray for your survival.:

OCT.: 'Temecula Terror' Halloween Haunt. Canceled for 2022.

OCT. 1-30: Big Horse Corn Maze. Canceled.

OCT. 8: Trick Or Treat at the Aloha Market. Enjoy Hawaiian BBQ, poke & iced coffee, too.

OCT. 8: Autumn Sunset Supper. Supports Sale Ranch Animal Sanctuary.

OCT. 8-30: 'Headless Horseman' Haunted Horse-Drawn Wagon Ride. With "moderate" scare level, so geared to families.

OCT. 20: Adults Harry Potter Trivia Night. For ages 18+ & registration required.

OCT. 24: Teen Movie Night. Get in the spirit with Halloween movie & candy!

OCT. 28: Annual Halloween Carnival: Town Square & Sam Hicks Park. Simultaneous events at two parks.

OCT. 28-29: CarnEvil Ball: Europa Village Wineries & Resort. A "spirited" good time with costume contest.

OCT. 29: Halloween Home Bike Tour. Go for a group spin & check out all the spooktacular decorations.

OCT. 29: Halloween Party at Batch Mead. Tickets on sale.

OCT. 29: HalloWine Party & Costume Contest: Peltzer Winery. Live music, food & costume contest.

NOV. 2: Da de los Muertos D.I.Y. Crafternoon. For ages 3-12. Sign up in advance, as in-person registration only.------------

OCT. 15: Rooted In Nature Craft Brew Festival: Marna O'Brien Park. Annual fall event with beer garden, live music, wildlife park & food trucks.

OCT. 22: Fall Family Fun Fair. With live music, puppeteer, free pony rides, bounce houses, rock- climbing wall, food trucks & more.

OCT. 29: Halloween Trunk-Or-Treat: Marna OBrien Park. "A family fun and safe Halloween event."

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Where To Find Pumpkin Patches, Halloween Fun Near Banning, Beaumont - Patch

Pritzker, Bailey square off in first of two debates, each accusing the other of lying – Northern Public Radio (WNIJ)

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NORMAL In the first of two official debates in the governors race this month, Gov. JB Pritzker on Thursday night finally faced the candidate whose victory in the Republican primary election this summer was helped along by $30 million in spending by the billionaire Democrat whom hes also spent months labeling too extreme for Illinois.

State Sen. Darren Bailey (R-Xenia) used the opportunity to call Pritzker dangerous and an arrogant liar to the governors face. Pritzker accused Bailey of telling more lies as the Republican repeated his well-worn criticisms of Democrats sweeping criminal justice law passed last year, which is centered on abolishing cash bail in Illinois.

Despite consistent polls showing Illinois voters ranking crime below other issues like the economy and reproductive rights, Bailey and other Republicans running for state office have made their opposition to the SAFE-T Act the centerpiece of their campaigns, with the GOP nominee repeatedly claiming Illinois will experience The Purge when the law is fully implemented on Jan. 1.

While some provisions of the law have already gone into effect including tightening standards for police use-of-force and expands the scenarios in which a law enforcement or corrections officer can be decertified, and thus deemed ineligible for hire in Illinois the states elimination of cash bail doesnt begin until 2023. Instead of allowing arrestees to post bond in order to get released from jail, the new system instructs judges to consider whether to detain alleged criminals based on the severity of their offense, the risk of an arrestee not appearing for court and the danger he or she poses to an individual or community if they were to be released. Thats not unlike the federal court system, which eliminated cash bail in the 1980s.

But in the nearly two years since Democrats pushed the law through the legislature in the waning hours of the General Assemblys Lame Duck session in January 2021, Republicans have amped up their criticism of the SAFE-T Act, claiming it will have the opposite of its intended effect, in part due to the phrasing within the 700-page law. While Democrats have recently become more public in their acknowledgement of the need for clarification within the law, theyre reticent to identify specific changes theyd make before January.

Well, I think that there are clarifications, Pritzker said in response to a debate question about what hed alter in the law.

But he stopped short of answering the question, instead turning his ire on the GOP.

As you know, the Republicans have put out a lot of disinformation a whole list of things that they say are non-detainable offenses. There's no such thing under the SAFE-T Act as non-detainable offenses. And again, the goal of [the law] is to keep murderers, rapists, domestic abusers and violent criminals in jail, and a poor young mother who shoplifts diapers and formula would be kept in for months if she doesnt have the $500 for bail.

Bailey claimed the elimination of cashless bail will be tantamount to revolving doors to every jail in the state of Illinois.

This SAFE-T Act must be repealed because it will let violent criminals and murderers out of jail before trial, Bailey said. Now, Governor Pritzker could have proposed a bail reform for nonviolent criminals. I would have supported that. But he didntAnd friends, we're going to have the exact same problem across the state that Chicago is experiencing after Jan. 1.

In reliably blue Illinois, Democrats have tried to wedge Republicans into a corner on the issue of abortion access, using the U.S. Supreme Courts June repeal of Roe v. Wade to energize both their base and independent voters activated by reproductive rights. GOP candidates, especially in areas where abortion access is a key political driver, have largely tried to avoid the subject another factor in centering campaign messaging around crime and the SAFE-T Act.

But Bailey has not been shy about his position on abortion as a much more conservative Republican than the brand of GOP politicians whove traditionally enjoyed political success in Illinois. Thursday nights debate featured clips of both candidates played in surround sound for the approximately 1,200 audience members in ISUs Braden Auditorium. One of those clips featured then-legislative candidate Bailey in a 2017 Facebook live video unearthed this summer, in which the Republican compared abortion to the Holocaust.

Bailey has previously accused Democrats and the media of exaggerating his statement that the attempted extermination of the Jews of WWII doesnt even compare on a shadow of the life that has been lost with abortion since its legalization. But he also defended his statement in August, claiming that Jewish leaders told him he was right. Asked on Thursday to identify those leaders, Bailey refused.

He also acknowledged the limited power he would have as governor to enact policies severely limiting abortions, especially with a Democratically led legislature.

Illinois has the most permissive abortion laws in the nation, Bailey said. Nothings going to change when Im governor. I couldnt change them.

Pritzker seized the opportunity to label Bailey as an extremist on abortion, saying the Republican wants to take away womens reproductive rights even in the case of rape and incest.

Youre so divisive, Bailey scolded.

Providing more legal protections to out-of-state women who seek abortions in Illinois, as well as healthcare providers who cross state lines to perform abortions was supposed to be one area the General Assembly addressed in a special session this summer, but momentum for that session never came to fruition.

Another policy area that Pritzker and Democratic lawmakers said theyd address in that special session was the states gun laws after a mass shooting at the Highland Park Independence Day Parade left seven dead and three dozen wounded. The governor and Bailey sparred over the need to enact more restrictive gun laws, with Bailey claiming the number of shootings in Illinois proved the states existing laws arent working.

A majority of Illinoisans and Americans favor banning assault-style weapons, as Congress did for a 10-year period between 1994 and 2004. Pritzker re-upped his call for that ban on Thursday night, but when asked why Democrats didnt take up the issue this summer, the governor punted responsibility to the legislature. Bailey, too, demurred to the General Assembly on that question, pivoting instead to talking about mental health, and at one point blaming the influx of migrants at the nations southern border.

The debate moved through a series of rapid-fire questions on a variety of topics, but Bailey tried to find moments to attack Pritzker on Illinois high property taxes and the states reputation as a poorly run government with an unattractive business climate. The governor touted the six credit upgrades Illinois has received from New York bond houses since last year, though the state still has the worst credit rating in the nation.

Pritzker claimed that if Democrats keep improving Illinois previously dismal financial picture, eventually the state could see lower taxes, but declined to answer how many years he thought that might take in a post-debate media availability.

Bailey, on the other hand, claimed he could save the state billions of dollars by implementing zero-based budgeting, wherein continuing appropriations are nixed and each line item in Illinois now $40-billion budget would have to be justified. But the Republican declined to elaborate on what he thought hed turn up in wasteful spending.

After the hour-long debate, Pritzker took a handful of questions from reporters who tried to pin him down on more specifics left unanswered in the back-and-forth between him and Bailey.

Bailey, however, did not choose to meet the press, instead sending a campaign staffer who briefly addressed reporters left waiting in the so-called spin room.

It is clear the senator won the debate tonight, Bailey spokesman Joe DeBose said before saying his boss wouldnt be answering questions.

Im just here to tell you that we won and winners dont need spin, he said, donning a black cowboy hat as he left the room.

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Pritzker, Bailey square off in first of two debates, each accusing the other of lying - Northern Public Radio (WNIJ)

Is the End of the Nancy Pelosi Era Near? The Jockeying to Succeed Her Is in Full Force – Vanity Fair

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Nobody can say for sure, but theres an expectation among aides on Capitol Hill that if Democrats lose control of the Houseas is the most likely scenario, per one Democratic aideNancy Pelosi will step down. There are the all-important caveats (Anyone who tells you that they know what Speaker Pelosi is going to dounless it is Speaker Pelosiis lying to you, another aide tells me), but as the November midterms inch closer, and the prospect of being in the minority grows, the jockeying to succeed one of the most storied Democratic leadership teams has begun in full force.

The drama isnt only around Pelosis next steps, however. Between the 82-year-old Speaker, House majority leader Steny Hoyer, 83, and House majority whip Jim Clyburn, 82Pelosis number two and threeDemocrats top leadership team combined has more than a century of experience in the House. Democratic lawmakers arent just eyeing who would replace their top leader; theres an appetite for a completely new generation to lead the party that could rankle some of Democrats most senior members.

It is always good to have a deep bench of people who are going to continue to lead the party in a way that resonates with people, Washington congresswoman Pramila Jayapal said. I think that there is a real sense that there is a real opportunity for some generational change in leadership, whether or not we hold the House. I think what we dont know is what that looks like, and who in the current leadership feels that way or doesnt feel that way.

In 2018, Pelosi agreed to a term limit for her speakership. But her office has routinely and repeatedly dismissed questions about her plans or possible succession; Pelosis office has said the Speaker is too focused on the midterms to be concerned about her title. The Speaker is not on a shift. Shes on a mission, Pelosi spokesperson Drew Hammill told Vanity Fair. Notably, Clyburn and Hoyer havent publicly stated their plans. Hoyer is proud to have the support of his colleagues and the American people and looks forward to building on this strong record by strengthening our majority and furthering efforts to ensure workers and families have the tools they need to Make It in America, Margaret Mulkerrin, Hoyers communications director, said when contacted for this article. (Clyburns office did not respond to a request for comment). If Hoyer or Clyburn make a play for the top job, or even if they make a bid to stay in their current roles, things could get messy quickly. For now, the mystery has led to a monthslong quiet race among some of the partys budding starsbased entirely on hypotheticals.

Conversations with congressional aides and lawmakers have painted the following picture of this shadow contest. New York congressman Hakeem Jeffries, currently the House Democratic Caucus chair, emerged as an early front-runner to take over for Pelosi. Jeffriess office declined to comment, but termed-out of his current position as caucus chair, Jeffries is fully expected to run for a higher rung in leadership. California congressman Adam Schiff is also seen as in the mix. While he hasnt announced any plans to make a bid for Speaker, he has had conversations with other members about the possibility. Schiffs prolific fundraising capabilitieshe touts a staggering nearly $20 million in his war chestwhich, as Puck recently laid out, could serve as an argument in his favor for a more prominent role within the caucus. Asked about the speakership, Schiff spokesperson Cate Hurley said, Chairman Schiff is doing everything possible to support vulnerable Democratic colleagues and promising challengers so that we can retain the House Democratic majority in November. That is where his time and energy are focused.

Any replacement would face the arduous task of propping up Democrats big tent. Despite her long tenure, Pelosis grip on the Democratic caucus has not gone unchallenged since she first became the leader in 2003. Particularly in recent leadership races, she has had to cut deals and make promises with factions of her party to hang on to the helm (like her pledge to step aside by the end of 2022). The partys historic premium on seniority has long been a source of tension; there is a sense among some members that they will never have a shot at leadership positions. Some feel the partys old guard is standing in the way of progress and change. These gripes again bubbled to the surface this month after House leadership unveiled a bill aimed at banning lawmakers from owning stocks that was disparaged by ethics experts. Virginia congresswoman Abigail Spanberger said it was designed to fail. This moment marks a failure of House leadershipand its yet another example of why I believe that the Democratic Party needs new leaders in the halls of Capitol Hill, as I have long made known, Spanberger said in a statement.

Im waiting and watching, Pennsylvania congresswoman Madeleine Dean said when asked about a changing of the guard within the party. Im certain there will be, at some point, a lot of change. You see already in the pipeline tremendous talent from folks who are leading us now at different levels, she said, in reference to the Democrats bench and the possibility of a new generation of leadership at the table.

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Is the End of the Nancy Pelosi Era Near? The Jockeying to Succeed Her Is in Full Force - Vanity Fair

‘Afraid of losing their power’: Judge decries GOP leaders who back Trump election claims – POLITICO

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The judiciary has to make it clear: It is not patriotism, it is not standing up for America to stand up for one man who knows full well that he lost instead of the Constitution he was trying to subvert, said Jackson, who was appointed by former President Barack Obama.

In addition, Jackson said, Trump and his allies are using rhetoric about the multiple criminal probes connected to Trump that contain dangerous undertones.

Some prominent figures in the Republican Party are cagily predicting or even outright calling for violence in the streets if one of the multiple investigations doesnt go his way, Jackson said.

The judges tough remarks came as she delivered a sentence to Jan. 6 defendant Kyle Young, who pleaded guilty to assaulting D.C. Police Officer Michael Fanone in some of the most brutal violence that occurred during the attack on the Capitol. Jackson sentenced Young to 86 months in prison, one of the stiffest sentences handed down, after describing his enthusiastic participation in the mob violence against Fanone, including by passing a taser to another rioter who used it on Fanones neck. Young, she noted, was accompanied amid the mob by his 16-year-old son.

But her most notable comments were directed not at Young but at Trump and GOP leaders themselves, describing them repeatedly as so beholden to one man that it has become heresy for Republicans to contradict his claims of election fraud.

Shes not the first federal judge to rebuke Trump in the context of Jan. 6 riot prosecutions. Judge Amit Mehta lamented that many of the low-level rioters were duped by powerful figures, including Trump, into marching on the Capitol, only to suffer criminal consequences as a result. Judge Reggie Walton called Trump a charlatan for his conduct related to the election. And a federal judge in California, David Carter, determined that Trumps actions related to Jan. 6 likely amounted to a criminal conspiracy to subvert the election.

But Jacksons comments were the most stinging assessment not only of Trump but those in the upper echelons of elected GOP leadership who have echoed him. She also pushed back at claims by some Trump allies that Jan. 6 defendants had been targeted for political reasons.

You were not prosecuted for being a Trump supporter. You were not arrested or charged and you will not be sentenced for exercising your first amendment rights, she said to Young. You are not a political prisoner You were trying to stop the singular thing that makes America America, the peaceful transfer of power. Thats what Stop the Steal meant.

Jackson is no stranger to high-profile Trump-related matters. She oversaw the trial of longtime Trump confidant Roger Stone, who was charged and convicted of lying to lawmakers investigating Russian interference in the 2016 election. In that trial, she castigated Stone after an ally used his social media account to post an image of her that appeared inside crosshairs.

Jackson also presided over one of the criminal cases against former Trump campaign chairman Paul Manafort, who pleaded guilty to financial crimes but was later accused by prosecutors of lying during his cooperation agreement.

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'Afraid of losing their power': Judge decries GOP leaders who back Trump election claims - POLITICO

Mastriano visits Potter County on the stump to become state’s 48th governor – Williamsport Sun-Gazette

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Pennsylvania candidate for Governor Doug Mastriano talks to a welcoming crowd gathered Wednesday afternoon at Larry's Sport Center in Galeton. Mastriano spoke during the hour-long campaign stop to a packed house. DAVE KENNEDY/Sun-Gazette

GALETON Along Route 6 are Doug Mastriano and Carrie DelRosso supporters, many of them showing their endorsement of the Republican gubernatorial candidate and lieutenant governor candidate with burma shave signs or the candidates signs in their front yards.

This is Potter County also known as Gods Country, and a visit by Mastriano on Wednesday drew the interest of folks who expressed a value in prayer and showed their overwhelming support for Mastriano, who was joined by his wife, Rebecca, whom he affectionately calls Rebbie.

The room inside Larrys Sport Center began to quickly fill up with Mastriano supporters and others who came to see and hear the candidate. The store owner invited the Sun-Gazette to cover the event. Soon, it was standing-room-only as Mastrianos bus pulled in, and those inside went outside to hold up signs and cheer.

The event was organized and hosted by Free Pa. Potter County Chapter, the Potter County Republican Party and Larrys Sport Center.

I love Potter County, Mastriano said, his first words to those he took the time to get photographs with as the line grew longer by the minute. Before long, Mastriano was introduced and he walked up to a podium and began to take aim at his opponent Attorney General Josh Shapiro, instantly painting the Democrat as part and parcel with liberal President Joe Biden and saying he would not only promote far-left policy but would thrive on it and make taxpayers pay for it.

Pennsylvania candidate for Governor Doug Mastriano talks to a welcoming crowd gathered Wednesday afternoon at Larry's Sport Center in Galeton. Mastriano spoke during the hour-long campaign stop to a packed house. DAVE KENNEDY/Sun-Gazette

A welcoming audience

Mastriano was in comfortable confines, and his voice boomed through the speakers inside the room that had motorcycles and ATVs for sale.

Although Mastriano was more than 350 miles away from Philadelphia, he mentioned it among his first remarks.

A recent fatal shooting in the Northeastern section of Mayfair, in the states largest city, was cited by the candidate as an example of the failed crime policy of Shapiro and Gov. Tom Wolf.

Mastriano said such slaughter on the streets has only multiplied in the past years. Under Shapiro, crime is up 40%, he said.

Pennsylvania candidate for Governor Doug Mastriano, right, and his wife Rebecca Mastriano, left, pose for photos with supporters Wednesday afternoon at Larry's Sport Center in Galeton. Mastriano spoke during the hour-long campaign stop to a packed house. DAVE KENNEDY/Sun-Gazette

In Philadelphia, 277 homicides, on average, had occurred each year when Wolf first took office. That unfortunate number of deaths by violence has shot up to 600 annually, and grave diggers cant find places to put the bodies, Mastriano said.

In the room decked in red, white and blue, Mastriano promised the people he would restore common sense to our state.

If elected, Mastriano said he would tackle the states economic crisis, with issues such as promoting energy independence and reducing inflation.

On day one we are going to drill and dig like weve never done before, he said.

That, he said, would provide so much prosperity that your kids are going to want to stay here.

Your grandkids are going to want to grow up here and they will have nice six-figure paying jobs, he said.

His energy policy included lowering gas prices and increasing all forms of energy production in the state, creating thousands of new energy-related jobs.

Mastrianos campaign pledged to reduce government overreach, lowering utility and food costs, enact universal voter identification and eliminate no-excuse mail-in voting and ballot drop boxes.

Social policy

Mastriano said he would end wokeness, establish a sex-trafficking task force and put a stop to what he called ghost flights carrying illegal migrants. Plus, he said, he would ensure Pennsylvania is no longer a sanctuary state.

While Mastriano promised he would sign executive orders, they would be codified in law with the General Assembly.

Its imperative that we re-elect a Republican House and Senate, he said.

Mastriano added that he would sign numerous laws, not ruling by edict, but coming in on day one, woke is broke in our state, he said, pointing to what he said is the flawed critical race theory. There will be no more reason to hate someone based on their skin color, he said.

He said he would quickly address gender-related concerns while promising to be a governor who respected individual rights.

On day one, no more boys on the girls team follow the science, he said. We are going to defend our women athletes and women.

The candidate also tied gender, in general, to safety in schools with no more boys in girls bathrooms, he said. Pronoun confusion will end in elementary school. No more, Whats your pronoun?'

He also assured parents there would be no more sexualization taught in elementary schools.

Mastriano said having to introduce a bill to strengthen parental rights shows you how far low weve gone under (Gov. Tom) Wolf and Shapiro.

We need to draw that line in the sand, he said.

Mastriano said his goal is to make Pennsylvania the Florida of the North, and he asked, What do you think?

That drew a rave response.

His reference was followed up with promotions to boost the economy and open up the energy sector.

Such energy focus would take the emphasis off of the world getting Russian oil and gas, he explained.

Well take their money, right? he asked.

Law and order

On day one, the state would be one supporting law and order, he added.

Were going to have the backs of our law enforcement, he said.

Mastriano continued this week on the stump asking for votes from Republicans, Independents and Democrats, alike.

Pennsylvania has had seven individuals who became president of the United States and 47 governors.

Either he or Shapiro will become the 48th governor on Nov. 8.

Mastriano is a retired U.S. Army colonel who contributed 30 years of military service. He is serving his second term as the senator from the 33rd district.

Hes made a pledge to visit each county in the state prior to election day.

The county cast 67% of the votes in the primary for Mastriano/Delrosso.

His secret weapon, his wife, shared how her husband was for womens rights, despite his stance on abortion.

You guys energize us by showing up and caring so much about your state and your nation, Rebbie Mastriano said.

The Democrats want to say that conservatives dont believe in womens rights, but Rebbie Mastriano said it was not true before rattling off a few womens rights:

Its a womans right to be born. Its a womans right to have a say in her childs education. she said. Its a womans right to have access to baby formula and affordable groceries to be able to feed her family.

It is a womans place to raise her child in a safe community, where the government enforces the law and prosecutes crime, she said. Its a womans right to live in a nation with a secure border.

Its a womans right to the First Amendment, she said. Its a womans right to the Second Amendment as well. Its a womans right to compete in sports that are not dominated by men.

Were tired of women being canceled and were tired of them taking our freedoms one-by-one, two-by-two. Were watching things dissolve.

But the people of Pennsylvania who are willing to stand and make their voice heard are going to make a difference and change things, she added.

After speaking, Rebbie Mastriano empowered those in the room to be the authority to go out and tell others what her husband stood for, to encourage them to register to vote by Oct. 20 and to go out and vote on election day or to mail in their vote.

Sharon Crandall, of Cherry Springs, said she came to show her support.

Id like to see him ensure the oil and gas industry remains healthy, Crandall said, before adding that shed also like to see, if elected, Mastriano keep the timber industries going and to find incentives for small businesses that cater to tourism in rural parts of the state.

As the candidate left, the crowd followed him to the bus, which also stopped in Mansfield in Tioga County and Beech Creek in Clinton County.

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Mastriano visits Potter County on the stump to become state's 48th governor - Williamsport Sun-Gazette

Google turns to machine learning to advance translation of text out in the real world – TechCrunch

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Google is giving its translation service an upgrade with a new machine learning-powered addition that will allow users to more easily translate text that appears in the real world, like on storefronts, menus, documents, business cards and other items. Instead of covering up the original text with the translation the new feature will instead smartly overlay the translated text on top of the image, while also rebuilding the pixels underneath with an AI-generated background to make the process of reading the translation feel more natural.

Often its that combination of the word plus the context like the background image that really brings meaning to what youre seeing, explained Cathy Edwards, VP and GM of Google Search, in a briefing ahead of todays announcement. You dont want to translate a text to cover up that important context that can come through in the images, she said.

Image Credits: Google

To make this process work, Google is using a machine learning technology known as generative adversarial networks, otherwise known as GAN models the same technology that powers the Magic Eraser feature to remove objects from photos taken on the Google Pixel smartphones. This advancement will allow Google to now blend the translated text into even very complex images, making the translation feel natural and seamless, the company says. It should seem as if youre looking at the item or object itself with translated text, not an overlay obscuring the image.

The feature is another development that seems to point to Googles plans to further invest in the creation of new AR glasses, as an ability to translate text in the real world could be a key selling point for such a device. The company noted that every month, people use Google to translate text and images over a billion times in more than 100 languages. It also this year began testing AR prototypes in public settings with a handful of employees and trusted testers, it said.

While theres obvious demand for better translation, its not clear if users will prefer to use their smartphone for translations rather than special eyewear. After all, Googles first entry into the smartglasses space, Google Glass, ultimately failed as a consumer product.

Google didnt speak to its long-term plans for the translation feature today, noting only that it would arrive sometime later this year.

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Google turns to machine learning to advance translation of text out in the real world - TechCrunch

Machine learning has predicted the winners of the Worlds – CyclingTips

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The singularity is coming for us, day by creeping day. Artificial intelligence is starting to write about cycling. It is starting to create pictures of cycling. And now, it is starting to predict the results of races that havent even happened yet.

There are humans involved at some point there always are, before the end of everything. In this case, it is a data and analytics consultancy called Decision Inc., Australia. The humans developed the modelling, fed it to their machine learning tool, let it marinate for a bit [that may be creative license] and then, the magic happened.

Machine Learning is a form of Artificial Intelligence which uses advanced data analytics [to] solve complex issues, explained Decision Inc, Australia CEO, Aiden Heke. It uses algorithms to best imitate how humans solve problems or predict outcomes.

Since the technology has evolved so much over the past few decades, we thought: why not use it to predict the outcome of the UCI World Championships?

First up, the womens road race:

A caveatthe Machines were crunching their numbers before Annemiek van Vleuten crashed out of the mixed team time trial, putting her start at risk. Also, apparently The Machines dont rate Grace Brown as a top 10 favourite. But all that aside? Those are certainly some credible names.

To the men:

Again, some curiosities in here for me. The podium seems credible, but I think Van der Poel is a bit more of a dark horse than this is letting on. Pogaar seems low; Almeida seems high. Im also furious about the Juraj Sagan erasure, but that is a me thing, not a you thing, and certainly not an AI thing.

Decision Inc. is likening their cycling foray to Deep Blue, an early machine learning venture from the mid-1990s that famously vanquished chess grandmaster Garry Kasparov. Its why were putting it to the test, to see just how far its come, said Decision Inc. CEO Aiden Heke. Were keen for everyone who fancies themselves as a bit of an expert on cycling to see if they can win where Kasparov couldnt: against the Machine.

If you want to show that you know more about this weekends cycling than a series of computer calculations, you can head to the companys Instagram account where you could win some signed cycling goodies.

Or, you can just wade into the comments here and tell us who your pick is. Thatd be fun too.

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Machine learning has predicted the winners of the Worlds - CyclingTips

Peking University released the first open-source dataset for machine learning applications in fast chip design – EurekAlert

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image:Example of the macro placement algorithm proposed by Google. view more

Credit: Science China Press

Electronic design automation (EDA) or computer-aided design (CAD) is a category of software tools for designing electronic systems, such as integrated circuits (ICs). By EDA tools, designers can finish the design flow of very large scale integrated (VLSI) chips with billions of transistors. EDA tools are essential to modern VLSI design due to the large scale and high complexity of electronic systems.

Recently, with the boom of artificial intelligence (AI) algorithms, the EDA community are actively exploring AI for IC techniques for the design of advanced chips. Many studies have explored machine learning (ML) based techniques for cross-stage prediction tasks in the design flow to achieve faster design convergence. For example, Google published a paper in Nature in 2021 entitled A graph placement methodology for fast chip design, leveraging reinforcement learning (RL) to place macros in a chip design. The basic idea is to regard the chip layout as a Go board, while each macro as a stone. In this way, an RL agent can be pre-trained with 10,000 internal design samples and learn to place one macro at a time. By finetuning the agent on each design for around 6 hours, it can outperform the performance of conventional EDA tools on Googles TPU chips, and achieve better performance, power, and area (PPA).

It can be seen that AI for EDA is being actively explored in the design automation community. Although building ML models usually requires a large amount of data, most studies can only generate small internal datasets for validation, due to the lack of large public datasets and the difficulty in data generation. To this end, an open-source dataset dedicated to ML tasks in EDA is urgently desired.

To address this issue, the research group from Peking University has released the first open-source dataset, called CircuitNet, which is dedicated to AI for IC applications in VLSI CAD. The dataset consists of over 10K samples and 54 synthesized circuit netlists from six open-source RISC-V designs, provides holistic support for cross-stage prediction tasks, and supports tasks including routing congestion prediction, design rule check (DRC) violation prediction and IR drop prediction. The main characteristics of CircuitNet can be summarized as follows:

To evaluate the effectiveness of CircuitNet, the authors validate the dataset by experiments on three prediction tasks: congestion, DRC violations, and IR drop. Each experiment takes a method from recent studies and evaluates its result on CircuitNet with the same evaluation metrics as the original studies. Overall, the results are consistent with the original publications, which demonstrates the effectiveness of CircuitNet. A detailed tutorial about the experimental setup is available on the webpage (https://circuitnet.github.io/). In the future, the authors plan to incorporate more data samples with large-scale designs in advanced technology nodes to improve the scale and diversity of the dataset.

See the article:

CircuitNet: An Open-Source Dataset for Machine Learning Applications in Electronic Design Automation (EDA)

https://doi.org/10.1007/s11432-022-3571-8

Science China Information Sciences

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.

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Peking University released the first open-source dataset for machine learning applications in fast chip design - EurekAlert

Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study – BMC…

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Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by Region, 2000-2019. Geneva: World Health Organization; 2020.

O'Brien RJ, Wong PC. Amyloid precursor protein processing and Alzheimer's disease. Annu Rev Neurosci. 2011;34:185204.

CAS PubMed PubMed Central Article Google Scholar

de la Monte SM, Tong M. Brain metabolic dysfunction at the core of Alzheimer's disease. Biochem Pharmacol. 2014;88(4):54859.

PubMed Article CAS Google Scholar

Procaccini C, Santopaolo M, Faicchia D, Colamatteo A, Formisano L, de Candia P, et al. Role of metabolism in neurodegenerative disorders. Metabolism. 2016;65(9):137690.

CAS PubMed Article Google Scholar

Silverberg N, Elliott C, Ryan L, Masliah E, Hodes R. NIA commentary on the NIA-AA Research Framework: Towards a biological definition of Alzheimer's disease. Alzheimers Dement. 2018;14(4):5768.

PubMed Article Google Scholar

Fiandaca MS, Mapstone ME, Cheema AK, Federoff HJ. The critical need for defining preclinical biomarkers in Alzheimer's disease. Alzheimers Dement. 2014;10(3 Suppl):S196212.

PubMed Google Scholar

Kaddurah-Daouk R, Krishnan KR. Metabolomics: a global biochemical approach to the study of central nervous system diseases. Neuropsychopharmacology. 2009;34(1):17386.

CAS PubMed Article Google Scholar

Gandy S, Bartfai T, Lees GV, Sano M. Midlife interventions are critical in prevention, delay, or improvement of Alzheimer's disease and vascular cognitive impairment and dementia. F1000Res. 2017;6:413.

PubMed PubMed Central Article CAS Google Scholar

Livingston G, Huntley J, Sommerlad A, Ames D, Ballard C, Banerjee S, et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020;396(10248):41346.

PubMed PubMed Central Article Google Scholar

Chouraki V, Preis SR, Yang Q, Beiser A, Li S, Larson MG, et al. Association of amine biomarkers with incident dementia and Alzheimer's disease in the Framingham Study. Alzheimers Dement. 2017;13(12):132736.

PubMed PubMed Central Article Google Scholar

Tynkkynen J, Chouraki V, van der Lee SJ, Hernesniemi J, Yang Q, Li S, et al. Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimers Dement. 2018;14(6):72333.

PubMed PubMed Central Article Google Scholar

van der Lee SJ, Teunissen CE, Pool R, Shipley MJ, Teumer A, Chouraki V, et al. Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimers Dement. 2018;14(6):70722.

PubMed Article Google Scholar

Cui M, Jiang Y, Zhao Q, Zhu Z, Liang X, Zhang K, et al. Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study. Alzheimers Dement. 2020;16(5):77988.

PubMed Article Google Scholar

Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, et al. Plasma phospholipids and prevalence of mild cognitive impairment and/or dementia in the ARIC Neurocognitive Study (ARIC-NCS). Alzheimers Dement (Amst). 2016;3:7382.

Article Google Scholar

Li D, Misialek JR, Boerwinkle E, Gottesman RF, Sharrett AR, Mosley TH, et al. Prospective associations of plasma phospholipids and mild cognitive impairment/dementia among African Americans in the ARIC Neurocognitive Study. Alzheimers Dement (Amst). 2017;6:110.

Article Google Scholar

Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. Lancet Neurol. 2016;15(5):455532.

PubMed Article Google Scholar

Fayosse A, Nguyen DP, Dugravot A, Dumurgier J, Tabak AG, Kivimki M, et al. Risk prediction models for dementia: role of age and cardiometabolic risk factors. BMC Med. 2020;18(1):107.

PubMed PubMed Central Article Google Scholar

Zou H, Hastie T. Regularization and Variable Selection via the Elastic Net. J R Stat Soc Ser B (Stat Methodol). 2005;67(2):30120.

Article Google Scholar

Krstajic D, Buturovic LJ, Leahy DE, Thomas S. Cross-validation pitfalls when selecting and assessing regression and classification models. J Cheminform. 2014;6(1):10.

PubMed PubMed Central Article Google Scholar

Marmot MG, Smith GD, Stansfeld S, Patel C, North F, Head J, et al. Health inequalities among British civil servants: the Whitehall II study. Lancet. 1991;337(8754):138793.

CAS PubMed Article Google Scholar

Soininen P, Kangas AJ, Wurtz P, Suna T, Ala-Korpela M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet. 2015;8(1):192206.

CAS PubMed Article Google Scholar

Sommerlad A, Perera G, Singh-Manoux A, Lewis G, Stewart R, Livingston G. Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008-2016. Alzheimers Dement. 2018;14(7):93343.

PubMed PubMed Central Article Google Scholar

Haynes W. Bonferroni Correction. In: Dubitzky W, Wolkenhauer O, Cho K-H, Yokota H, editors. Encyclopedia of Systems Biology. New York: Springer New York; 2013. p. 154.

Chapter Google Scholar

Hastie T, Tibshirani R, Friedman J. Model Assessment and Selection. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. New York: Springer New York; 2009. p. 21959.

Book Google Scholar

Friedman J, Hastie T, Tibshirani R. Regularization Paths for Generalized Linear Models via Coordinate Descent. J Stat Softw. 2010;33(1):122.

PubMed PubMed Central Article Google Scholar

Royston P. Explained Variation for Survival Models. Stata J. 2006;6(1):8396.

Article Google Scholar

Cattaneo M, Malighetti P, Spinelli D. Estimating Receiver Operative Characteristic Curves for Time-dependent Outcomes: The Stroccurve Package. Stata J. 2017;17(4):101523.

Article Google Scholar

Pencina MJ, D'Agostino RB. Overall C as a measure of discrimination in survival analysis: model specific population value and confidence interval estimation. Stat Med. 2004;23(13):210923.

PubMed Article Google Scholar

Demler OV, Paynter NP, Cook NR. Tests of calibration and goodness-of-fit in the survival setting. Stat Med. 2015;34(10):165980.

PubMed PubMed Central Article Google Scholar

Kang L, Chen W, Petrick NA, Gallas BD. Comparing two correlated C indices with right-censored survival outcome: a one-shot nonparametric approach. Stat Med. 2015;34(4):685703.

PubMed Article Google Scholar

Jack CR Jr, Knopman DS, Jagust WJ, Petersen RC, Weiner MW, Aisen PS, et al. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers. Lancet Neurol. 2013;12(2):20716.

CAS PubMed PubMed Central Article Google Scholar

Verberk IMW, Laarhuis MB, van den Bosch KA, Ebenau JL, van Leeuwenstijn M, Prins ND, et al. Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study. Lancet Healthy Longevity. 2021;2(2):e8795.

Article Google Scholar

Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE, et al. Plasma P-tau181 in Alzheimer's disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer's dementia. Nat Med. 2020;26(3):37986.

CAS PubMed Article Google Scholar

Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL, et al. Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol. 2020;19(5):42233.

CAS PubMed Article Google Scholar

Licher S, Yilmaz P, Leening MJG, Wolters FJ, Vernooij MW, Stephan BCM, et al. External validation of four dementia prediction models for use in the general community-dwelling population: a comparative analysis from the Rotterdam Study. Eur J Epidemiol. 2018;33(7):64555.

PubMed PubMed Central Article Google Scholar

Orei M, Hytylinen T, Herukka SK, Sysi-Aho M, Mattila I, Seppnan-Laakso T, et al. Metabolome in progression to Alzheimer's disease. Transl Psychiatry. 2011;1(12):e57.

PubMed PubMed Central Article CAS Google Scholar

Jiang Y, Zhu Z, Shi J, An Y, Zhang K, Wang Y, et al. Metabolomics in the Development and Progression of Dementia: A Systematic Review. Front Neurosci. 2019;13:343.

PubMed PubMed Central Article Google Scholar

Casanova R, Varma S, Simpson B, Kim M, An Y, Saldana S, et al. Blood metabolite markers of preclinical Alzheimer's disease in two longitudinally followed cohorts of older individuals. Alzheimers Dement. 2016;12(7):81522.

PubMed PubMed Central Article Google Scholar

Low DY, Lefvre-Arbogast S, Gonzlez-Domnguez R, Urpi-Sarda M, Micheau P, Petera M, et al. Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort. Mol Nutr Food Res. 2019;63(18):e1900177.

PubMed Article CAS Google Scholar

Ma YH, Shen XN, Xu W, Huang YY, Li HQ, Tan L, et al. A panel of blood lipids associated with cognitive performance, brain atrophy, and Alzheimer's diagnosis: A longitudinal study of elders without dementia. Alzheimers Dement (Amst). 2020;12(1):e12041.

Google Scholar

Mapstone M, Cheema AK, Fiandaca MS, Zhong X, Mhyre TR, MacArthur LH, et al. Plasma phospholipids identify antecedent memory impairment in older adults. Nat Med. 2014;20(4):4158.

CAS PubMed PubMed Central Article Google Scholar

Stamate D, Kim M, Proitsi P, Westwood S, Baird A, Nevado-Holgado A, et al. A metabolite-based machine learning approach to diagnose Alzheimer-type dementia in blood: Results from the European Medical Information Framework for Alzheimer disease biomarker discovery cohort. Alzheimers Dement (N Y). 2019;5:9338.

Article Google Scholar

Crane PK, Walker R, Hubbard RA, Li G, Nathan DM, Zheng H, et al. Glucose levels and risk of dementia. N Engl J Med. 2013;369(6):5408.

CAS PubMed PubMed Central Article Google Scholar

Strachan MW. R D Lawrence Lecture 2010. The brain as a target organ in Type 2 diabetes: exploring the links with cognitive impairment and dementia. Diabet Med. 2011;28(2):1417.

CAS PubMed Article Google Scholar

Correia SC, Santos RX, Carvalho C, Cardoso S, Candeias E, Santos MS, et al. Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation. Brain Res. 2012;1441:6478.

CAS PubMed Article Google Scholar

Kellar D, Craft S. Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches. Lancet Neurol. 2020;19(9):75866.

CAS PubMed Article Google Scholar

Helmer C, Stengel B, Metzger M, Froissart M, Massy ZA, Tzourio C, et al. Chronic kidney disease, cognitive decline, and incident dementia: the 3C Study. Neurology. 2011;77(23):204351.

CAS PubMed Article Google Scholar

Seliger SL, Siscovick DS, Stehman-Breen CO, Gillen DL, Fitzpatrick A, Bleyer A, et al. Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol. 2004;15(7):190411.

PubMed Article Google Scholar

Hatanaka H, Hanyu H, Fukasawa R, Hirao K, Shimizu S, Kanetaka H, et al. Differences in peripheral oxidative stress markers in Alzheimer's disease, vascular dementia and mixed dementia patients. Geriatr Gerontol Int. 2015;15(Suppl 1):538.

PubMed Article Google Scholar

Duarte PO, Duarte MGF, Pelichek A, Pfrimer K, Ferriolli E, Moriguti JC, et al. Cardiovascular risk factors and inflammatory activity among centenarians with and without dementia. Aging Clin Exp Res. 2017;29(3):4117.

PubMed Article Google Scholar

Hata J, Ohara T, Katakura Y, Shimizu K, Yamashita S, Yoshida D, et al. Association Between Serum -Alanine and Risk of Dementia: The Hisayama Study. Am J Epidemiol. 2019;188(9):163745.

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Circulating serum metabolites as predictors of dementia: a machine learning approach in a 21-year follow-up of the Whitehall II cohort study - BMC...

Machine Learning Can Be Used to Improve the Ability to Predict Adverse Pregnancy Outcomes in Women with Lupus – Lupus Foundation of America

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Nearly 20% of pregnancies in people with lupus result in an adverse pregnancy outcome (APO). In a new study, scientists were able to improve prediction accuracy of APOs using machine learning. Machine learning refers to the process by which a computer is able to improve its own performance by continuously incorporating new data into an existing statistical model.

Using a previously developed APO prediction model utilizing data from a larger multi-center, multi-ethnic study of lupus pregnancies known as the Predictors of pRegnancy Outcome: bioMarkers In Antiphospholid Antibody Syndrome and the Systemic Lupus Erythematosus (PROMISSE) study, and statistical analysis coupled with machine learning, researchers analyzed data from 385 women in their first trimester of pregnancy. They identified lupus anticoagulant positivity, disease assessment score, diastolic blood pressure or resting heartbeat, current use of antihypertension medication, and platelet count as significant baseline predictors of APO.

Researchers suggest that the ability to identify, lupus patients at high risk of APO early in pregnancy, could enhance the capacity to manage these patients and conduct trials of new treatments to prevent pre-eclampsia and placental insufficiency.

Further studies to identify new biomarkers and risk factors for APO are still needed. The Lupus Foundation of America provided the study author, Jane Salmon, MD, with a three-year grant for her IMPACT study, the first trial of a biologic therapy to prevent adverse pregnancy outcomes in high-risk pregnancies in patients with antiphospholipid syndrome (APS) with or without systemic lupus erythematosus (SLE), which also helped support this new research. Learn more about lupus and pregnancy.

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Machine Learning Can Be Used to Improve the Ability to Predict Adverse Pregnancy Outcomes in Women with Lupus - Lupus Foundation of America


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