Albert Hsiao, M.D., and his colleagues at the University of California, San Diego (USCD) health system had been working for 18 months on anartificial intelligence programdesigned to help doctors identify pneumonia on a chest X-ray. When thecoronavirushit the U.S., they decided to see what it could do.

The researchers quickly deployed the application, which dots X-ray images with spots of color where there may be lung damage or other signs of pneumonia. It has now been applied to more than 6,000 chest X-rays, and its providing some value in diagnosis, said Hsiao, director of UCSDs augmented imaging and artificial intelligence data analytics laboratory.

His team is one of several around the country that has pushed AI programs developed in a calmer time into the COVID-19 crisis to perform tasks like deciding which patients face the greatest risk of complications and which can be safely channeled into lower-intensity care.

ASCO Explained: Expert predictions and takeaways from the world's biggest cancer meeting

Join FiercePharma for our ASCO pre- and post-show webinar series. We'll bring together a panel of experts to preview what to watch for at ASCO. Cancer experts will highlight closely watched data sets to be unveiled at the virtual meeting--and discuss how they could change prescribing patterns. Following the meeting, well do a post-show wrap up to break down the biggest data that came out over the weekend, as well as the implications they could have for prescribers, patients and drugmakers.

The machine-learning programs scroll through millions of pieces of data to detect patterns that may be hard for clinicians to discern. Yet few of the algorithms have been rigorously tested against standard procedures. So while they often appear helpful, rolling out the programs in the midst of a pandemic could be confusing to doctors or even dangerous for patients, some AI experts warn.

AI is being used for things that are questionable right now, said Eric Topol, M.D., director of the Scripps Research Translational Institute and author of several books on health IT.

Topol singled out a system created byEpic, a major vendor of electronic health record software, that predicts which coronavirus patients may become critically ill. Using the tool before it has been validated is pandemic exceptionalism, he said.

Epic said the companys model had been validated with data from more 16,000 hospitalized COVID-19 patients in 21 healthcare organizations. No research on the tool has been published, but, in any case, it was developed to help clinicians make treatment decisions and is not a substitute for their judgment, said James Hickman, a software developer on Epics cognitive computing team.

Others see the COVID-19 crisis as an opportunity to learn about the value of AI tools.

My intuition is its a little bit of the good, bad and ugly, said Eric Perakslis, Ph.D., a data science fellow at Duke University and former chief information officer at the FDA. Research in this setting is important.

Nearly $2 billion poured into companies touting advancements in healthcare AI in 2019. Investments in the first quarter of 2020 totaled $635 million, up from $155 million in the first quarter of 2019, according to digital health technology funderRock Health.

At least three healthcare AI technology companies have made funding deals specific to the COVID-19 crisis, includingVida Diagnostics, an AI-powered lung-imaging analysis company, according to Rock Health.

Overall, AIs implementation in everyday clinical care is less common than hype over the technology would suggest. Yet the coronavirus crisis has inspired some hospital systems to accelerate promising applications.

UCSD sped up its AI imaging project, rolling it out in only two weeks.

Hsiaos project, with research funding from Amazon Web Services, the UC system and the National Science Foundation (NSF), runs every chest X-ray taken at its hospital through an AI algorithm. While no data on the implementation have been published yet, doctors report that the tool influences their clinical decision-making about a third of the time, said Christopher Longhurst, M.D., UCSD Healths chief information officer.

The results to date are very encouraging, and were not seeing any unintended consequences, he said. Anecdotally, were feeling like its helpful, not hurtful.

AI has advanced further in imaging than other areas of clinical medicine because radiological images have tons of data for algorithms to process, and more data make the programs more effective, said Longhurst.

But while AI specialists have tried to get AI to do things like predict sepsis and acute respiratory distressresearchers at Johns Hopkins Universityrecently won a NSF grantto use it to predict heart damage in COVID-19 patientsit has been easier to plug it into less risky areas such as hospital logistics.

In New York City, two major hospital systems are using AI-enabled algorithms to help them decide when and how patients should move into another phase of care or be sent home.

AtMount Sinai Health System, an artificial intelligence algorithm pinpoints which patients might be ready to be discharged from the hospital within 72 hours, said Robbie Freeman, vice president of clinical innovation at Mount Sinai.

Freeman described the AIs suggestion as a conversation starter, meant to help assist clinicians working on patient cases decide what to do. AI isnt making the decisions.

NYU Langone Healthhas developed a similar AI model. It predicts whether a COVID-19 patient entering the hospital will suffer adverse events within the next four days, said Yindalon Aphinyanaphongs, M.D., Ph.D., who leads NYU Langones predictive analytics team.

The model will be run in a four- to six-week trial with patients randomized into two groups: one whose doctors will receive the alerts, and another whose doctors will not. The algorithm should help doctors generate a list of things that may predict whether patients are at risk for complications after theyre admitted to the hospital, Aphinyanaphongs said.

Some health systems are leery of rolling out a technology that requires clinical validation in the middle of a pandemic. Others say they didnt need AI to deal with the coronavirus.

Stanford Health Careis not using AI to manage hospitalized patients with COVID-19, saidRon Li, M.D., the centers medical informatics director for AI clinical integration. The San Francisco Bay Areahasnt seen the expected surge of patientswho would have provided the mass of data needed to make sure AI works on a population, he said.

Outside the hospital, AI-enabled risk factor modeling is being used to help health systems track patients who arent infected with the coronavirus but might be susceptible to complications if they contract COVID-19.

At Scripps Health in San Diego, clinicians are stratifying patients to assess their risk of getting COVID-19 and experiencing severe symptoms using a risk-scoring model that considers factors like age, chronic conditions and recent hospital visits. When a patient scores seven or higher, a triage nurse reaches out with information about the coronavirus and may schedule an appointment.

Though emergencies provide unique opportunities to try out advanced tools, its essential for health systems to ensure doctors are comfortable with them and to use the tools cautiously, with extensive testing and validation, Topol said.

When people are in the heat of battle and overstretched, it would be great to have an algorithm to support them, he said. We just have to make sure the algorithm and the AI tool isnt misleading, because lives are at stake here.

Kaiser Health News(KHN) is a national health policy news service. It is an editorially independent program of theHenry J. Kaiser Family Foundationwhich is not affiliated with Kaiser Permanente.

ThisKHNstory first published onCalifornia Healthline, a service of theCalifornia Health Care Foundation

Continue reading here:
Coronavirus tests the value of artificial intelligence in medicine - FierceBiotech

Much has been said about the potential of artificial intelligence (AI) to transform many aspects of business and society for the better. In the opposite corner, science fiction has the doomsday narrative covered handily.

To ensure AI products function as their developers intend - and to avoid a HAL9000 or Skynet-style scenario - the common narrative suggests that data used as part of the machine learning (ML) process must be carefully curated, to minimise the chances the product inherits harmful attributes.

According to Richard Tomsett, AI Researcher at IBM Research Europe, our AI systems are only as good as the data we put into them. As AI becomes increasingly ubiquitous in all aspects of our lives, ensuring were developing and training these systems with data that is fair, interpretable and unbiased is critical.

Left unchecked, the influence of undetected bias could also expand rapidly as appetite for AI products accelerates, especially if the means of auditing underlying data sets remain inconsistent and unregulated.

However, while the issues that could arise from biased AI decision making - such as prejudicial recruitment or unjust incarceration - are clear, the problem itself is far from black and white.

Questions surrounding AI bias are impossible to disentangle from complex and wide-ranging issues such as the right to data privacy, gender and race politics, historical tradition and human nature - all of which must be unraveled and brought into consideration.

Meanwhile, questions over who is responsible for establishing the definition of bias and who is tasked with policing that standard (and then policing the police) serve to further muddy the waters.

The scale and complexity of the problem more than justifies doubts over the viability of the quest to cleanse AI of partiality, however noble it may be.

Algorithmic bias can be described as any instance in which discriminatory decisions are reached by an AI model that aspires to impartiality. Its causes lie primarily in prejudices (however minor) found within the vast data sets used to train machine learning (ML) models, which act as the fuel for decision making.

Biases underpinning AI decision making could have real-life consequences for both businesses and individuals, ranging from the trivial to the hugely significant.

For example, a model responsible for predicting demand for a particular product, but fed data relating to only a single demographic, could plausibly generate decisions that lead to the loss of vast sums in potential revenue.

Equally, from a human perspective, a program tasked with assessing requests for parole or generating quotes for life insurance plans could cause significant damage if skewed by an inherited prejudice against a certain minority group.

According to Jack Vernon, Senior Research Analyst at IDC, the discovery of bias within an AI product can, in some circumstances, render it completely unfit for purpose.

Issues arise when algorithms derive biases that are problematic or unintentional. There are two usual sources of unwanted biases: data and the algorithm itself, he told TechRadar Pro via email.

Data issues are self-explanatory enough, in that if features of a data set used to train an algorithm have problematic underlying trends, there's a strong chance the algorithm will pick up and reinforce these trends.

Algorithms can also develop their own unwanted biases by mistake...Famously, an algorithm for identifying polar bears and brown bears had to be discarded after it was discovered the algorithm based its classification on whether there was snow on the ground or not, and didn't focus on the bear's features at all.

Vernons example illustrates the eccentric ways in which an algorithm can diverge from its intended purpose - and its this semi-autonomy that can pose a threat, if a problem goes undiagnosed.

The greatest issue with algorithmic bias is its tendency to compound already entrenched disadvantages. In other words, bias in an AI product is unlikely to result in a white-collar banker having their credit card application rejected erroneously, but may play a role in a member of another demographic (which has historically had a greater proportion of applications rejected) suffering the same indignity.

The consensus among the experts we consulted for this piece is that, in order to create the least prejudiced AI possible, a team made up of the most diverse group of individuals should take part in its creation, using data from the deepest and most varied range of sources.

The technology sector, however, has a long-standing and well-documented issue with diversity where both gender and race are concerned.

In the UK, only 22% of directors at technology firms are women - a proportion that has remained practically unchanged for the last two decades. Meanwhile, only 19% of the overall technology workforce are female, far from the 49% that would accurately represent the ratio of female to male workers in the UK.

Among big tech, meanwhile, the representation of minority groups has also seen little progress. Google and Microsoft are industry behemoths in the context of AI development, but the percentage of black and Latin American employees at both firms remains miniscule.

According to figures from 2019, only 3% of Googles 100,000+ employees were Latin American and 2% were black - both figures up by only 1% over 2014. Microsofts record is only marginally better, with 5% of its workforce made up of Latin Americans and 3% black employees in 2018.

The adoption of AI in enterprise, on the other hand, skyrocketed during a similar period according to analyst firm Gartner, increasing by 270% between 2015-2019. The clamour for AI products, then, could be said to be far greater than the commitment to ensuring their quality.

Patrick Smith, CTO at data storage firm PureStorage, believes businesses owe it not just to those that could be affected by bias to address the diversity issue, but also to themselves.

Organisations across the board are at risk of holding themselves back from innovation if they only recruit in their own image. Building a diversified recruitment strategy, and thus a diversified employee base, is essential for AI because it allows organisations to have a greater chance of identifying blind spots that you wouldnt be able to see if you had a homogenous workforce, he said.

So diversity and the health of an organisation relates specifically to diversity within AI, as it allows them to address unconscious biases that otherwise could go unnoticed.

Further, questions over precisely how diversity is measured add another layer of complexity. Should a diverse data set afford each race and gender equal representation, or should representation of minorities in a global data set reflect the proportions of each found in the world population?

In other words, should data sets feeding globally applicable models contain information relating to an equal number of Africans, Asians, Americans and Europeans, or should they represent greater numbers of Asians than any other group?

The same question can be raised with gender, because the world contains 105 men for every 100 women at birth.

The challenge facing those whose goal it is to develop AI that is sufficiently impartial (or perhaps proportionally impartial) is the challenge facing societies across the globe. How can we ensure all parties are not only represented, but heard - and when historical precedent is working all the while to undermine the endeavor?

The importance of feeding the right data into ML systems is clear, correlating directly with AIs ability to generate useful insights. But identifying the right versus wrong data (or good versus bad) is far from simple.

As Tomsett explains, data can be biased in a variety of ways: the data collection process could result in badly sampled, unrepresentative data; labels applied to the data through past decisions or human labellers may be biased; or inherent structural biases that we do not want to propagate may be present in the data.

Many AI systems will continue to be trained using bad data, making this an ongoing problem that can result in groups being put at a systemic disadvantage, he added.

It would be logical to assume that removing data types that could possibly inform prejudices - such as age, ethnicity or sexual orientation - might go some way to solving the problem. However, auxiliary or adjacent information held within a data set can also serve to skew output.

An individuals postcode, for example, might reveal much about their characteristics or identity. This auxiliary data could be used by the AI product as a proxy for the primary data, resulting in the same level of discrimination.

Further complicating matters, there are instances in which bias in an AI product is actively desirable. For example, if using AI to recruit for a role that demands a certain level of physical strength - such as firefighter - it is sensible to discriminate in favor of male applicants, because biology dictates the average male is physically stronger than the average female. In this instance, the data set feeding the AI product is indisputably biased, but appropriately so.

This level of depth and complexity makes auditing for bias, identifying its source and grading data sets a monumentally challenging task.

To tackle the issue of bad data, researchers have toyed with the idea of bias bounties, similar in style to bug bounties used by cybersecurity vendors to weed out imperfections in their services. However, this model operates on the assumption an individual is equipped to to recognize bias against any other demographic than their own - a question worthy of a whole separate debate.

Another compromise could be found in the notion of Explainable AI (XAI), which dictates that developers of AI algorithms must be able to explain in granular detail the process that leads to any given decision generated by their AI model.

Explainable AI is fast becoming one of the most important topics in the AI space, and part of its focus is on auditing data before its used to train models, explained Vernon.

The capability of AI explainability tools can help us understand how algorithms have come to a particular decision, which should give us an indication of whether biases the algorithm is following are problematic or not.

Transparency, it seems, could be the first step on the road to addressing the issue of unwanted bias. If were unable to prevent AI from discriminating, the hope is we can at least recognise discrimination has taken place.

The perpetuation of existing algorithmic bias is another problem that bears thinking about. How many tools currently in circulation are fueled by significant but undetected bias? And how many of these programs might be used as the foundation for future projects?

When developing a piece of software, its common practice for developers to draw from a library of existing code, which saves time and allows them to embed pre-prepared functionalities into their applications.

The problem, in the context of AI bias, is that the practice could serve to extend the influence of bias, hiding away in the nooks and crannies of vast code libraries and data sets.

Hypothetically, if a particularly popular piece of open source code were to exhibit bias against a particular demographic, its possible the same discriminatory inclination could embed itself at the heart of many other products, unbeknownst to their developers.

According to Kacper Bazyliski, AI Team Leader at software development firm Neoteric, it is relatively common for code to be reused across multiple development projects, depending on their nature and scope.

If two AI projects are similar, they often share some common steps, at least in data pre- and post-processing. Then its pretty common to transplant code from one project to another to speed up the development process, he said.

Sharing highly biased open source data sets for ML training makes it possible that the bias finds its way into future products. Its a task for the AI development teams to prevent from happening.

Further, Bazyliski notes that its not uncommon for developers to have limited visibility into the kinds of data going into their products.

In some projects, developers have full visibility over the data set, but its quite often that some data has to be anonymized or some features stored in data are not described because of confidentiality, he noted.

This isnt to say code libraries are inherently bad - they are no doubt a boon for the worlds developers - but their potential to contribute to the perpetuation of bias is clear.

Against this backdrop, it would be a serious mistake to...conclude that technology itself is neutral, reads a blog post from Google-owned AI firm DeepMind.

Even when bias does not originate with software developers, it is still repackaged and amplified by the creation of new products, leading to new opportunities for harm.

Bias is an inherently loaded term, carrying with it a host of negative baggage. But it is possible bias is more fundamental to the way we operate than we might like to think - inextricable from the human character and therefore anything we produce.

According to Alexander Linder, VP Analyst at Gartner, the pursuit of impartial AI is misguided and impractical, by virtue of this very human paradox.

Bias cannot ever be totally removed. Even the attempt to remove bias creates bias of its own - its a myth to even try to achieve a bias-free world, he told TechRadar Pro.

Tomsett, meanwhile, strikes a slightly more optimistic note, but also gestures towards the futility of an aspiration to total impartiality.

Because there are different kinds of bias and it is impossible to minimize all kinds simultaneously, this will always be a trade-off. The best approach will have to be decided on a case by case basis, by carefully considering the potential harms from using the algorithm to make decisions, he explained.

Machine learning, by nature, is a form of statistical discrimination: we train machine learning models to make decisions (to discriminate between options) based on past data.

The attempt to rid decision making of bias, then, runs at odds with the very mechanism humans use to make decisions in the first place. Without a measure of bias, AI cannot be mobilised to work for us.

It would be patently absurd to suggest AI bias is not a problem worth paying attention to, given the obvious ramifications. But, on the other hand, the notion of a perfectly balanced data set, capable of rinsing all discrimination from algorithmic decision-making, seems little more than an abstract ideal.

Life, ultimately, is too messy. Perfectly egalitarian AI is unachievable, not because its a problem that requires too much effort to solve, but because the very definition of the problem is in constant flux.

The conception of bias varies in line with changes to societal, individual and cultural preference - and it is impossible to develop AI systems within a vacuum, at a remove from these complexities.

To be able to recognize biased decision making and mitigate its damaging effects is critical, but to eliminate bias is unnatural - and impossible.

More here:
Playing God: Why artificial intelligence is hopelessly biased - and always will be - TechRadar India

Newswise Sedentary behaviours, poor sleep and questionable food choices are major contributors of chronic disease, including diabetes, anxiety, heart disease and many cancers. But what if we could prevent these through the power of smart technologies?

In a new University of South Australia research project announced today and funded by $1,118,593 from the Medical Research Future Fund (MRFF), researchers will help Australians tackle chronic disease through a range of digital technologies to improve their health.

Using apps, wearables, social media and artificial intelligence, the research will show whether technology can modify and improve peoples behaviours to create meaningful and lasting lifestyle changes that can ward off chronic disease.

Chronic disease is the leading cause of illness, disability and death in Australia with about half of Australians having a least one of eight major conditions including CVD, cancer, arthritis, asthma, back pain, diabetes, pulmonary disease and mental health conditions.

Nearly 40 per cent of chronic disease is preventable through modifiable lifestyle and diet factors.

The research will assess the ability of digital technologies to improve the health and wellbeing across a range of populations, health behaviours and outcomes, with a specific focus on how they can negate poor health outcomes associated high-risk events such as school holidays or Christmas (when people are more likely to indulge and less likely to exercise); where technology could better track the activity among hospital inpatients, outpatients and home-patients (to help recovery from illness and surgery, leading to improved patient outcomes); and how new artificial intelligence-driven virtual health assistants can improve boost health among high-risk groups, such as older adults.

Lead researcher, UniSAs Associate Professor Carol Maher says the research aims to deliver accessible and affordable health solutions for all Australians.

Poor lifestyle patterns a lack of exercise, excess sedentary behaviour, a lack of sleep and poor diets are leading modifiable causes of death and disease in Australia, Assoc Prof Maher says.

Technology has a huge amount to offer in terms of improving lifestyle and health, especially in terms of personalisation and accessibility, but it has to be done thoroughly and it has to be done well.

Research plays an important role in helping understand the products that are most effective, which will see us working with existing commercial technologies and applying and testing them in a new way, as well as developing bespoke software for specific, unmet needs.

The great advantage of technology-delivered programs is that with careful design, once they are developed and evaluated, they can be delivered very affordably and on a massive scale.

If we are to make any change in the prevalence of chronic disease in Australia, we must plan to do it en masse.

The research aims to bridge the gap between academic rigour and commercial offerings so ensure that every Australian has access to the health supports they need.

One of the challenges we face is that many people who could benefit from digital health technologies are intimidated by them for example, older adults who are not that comfortable with technology, or health professionals who are just used to doing things a certain way, Assoc Prof Maher says.

Change can be hard, but when were making leaps in the right direction to improve lifestyle and health of the Australian community, these changes are worth considering.

See the article here:
Harness artificial intelligence and take control your health - Newswise

The command is responsible for defending the continental United States and territories and provides military aid to non-military agencies such as the Federal Emergency Management Agency.

The command has deployed Army and Navy medical personnel to New York, sent Navy hospital ships to New York City and Los Angeles, and helped set up field hospitals in areas where local health care facilities were overwhelmed with patients.

Northern Command has said it has been working with several top U.S. technology companies including Apple, Microsoft, mapping software maker Esri and Monkton, a company that helps developers build secure apps for classified purposes to help FEMA and other agencies during the pandemic.

Although the Pentagon has faced skepticism from some tech companies in its pursuit of artificial intelligence technologies,and outright refusal by Google to continue collaborating on a Pentagon project to identify and label objects in drone videos,the pandemic appears to have changed the calculation, Shanahan said.

As soon as the Pentagon launched Project Salus to build predictive models of shortages during the pandemic, there has been an outpouring of support from private companies, as well as major universities, Shanahan said. The top tech companies in the country and their teams of artificial intelligence and machine learning specialists have shown a strong desire to work with the Defense Department, he said.

See the rest here:
Pentagon AI chief says the tech could help spot future pandemics earlier - Roll Call

Artificial intelligence can bring even greater precision to controlling highly sensitive systems in automotive production, as a pilot project in the paint shop of the BMW Group's Munich plant has demonstrated.

Despite state-of-the-art filtration technology, the content of finest dust particles in paint lines varies depending on the ambient air drawn in. If the dust content exceeded the threshold, the still wet paint could trap particles, thus visually impairing the painted surface.

Artificial Intelligence (AI) specialists from central planning and the Munich plant have now found a way to avoid this situation altogether. Every freshly painted car body must undergo an automatic surface inspection in the paint shop. Data gathered in these inspections are used to develop a comprehensive database for dust particle analysis. The specialists are now applying AI algorithms to compare live data from dust particle sensors in the paint booths and dryers with this database.

"Data-based solutions help us secure and further extend our stringent quality requirements to the benefit of our customers. Smart data analytics and AI serve as key decision-making aids for our team when it comes to developing process improvements. We have filed for several patents relating to this innovative dust particle analysis technology," said Albin Dirndorfer, Senior Vice President Painted Body, Finish and Surface at the BMW Group.

(Also read: Ford is working on a car paint that can protect your vehicle from bird poop)

Two specific examples show the benefits of this new AI solution: Where dust levels are set to rise owing to the season or during prolonged dry periods, the algorithm can detect this trend in good time and is able to determine, for example, an earlier time for filter replacement.

Additional patterns can be detected where this algorithm is used alongside other analytical tools. For example, analysis could further show that the facility that uses ostrich feathers to remove dust particles from car bodies needs to be fine-tuned.

The BMW Group's AI specialists see enormous potential in dust particle analysis. Based on information from numerous sensors and data from surface inspections, the algorithm monitors over 160 features relating to the car body and is able to predict the quality of paint application very accurately.

This AI solution will be suitable for application in series production when an even broader database for the algorithm has been developed. In particular, this requires additional measuring points and even more precise sensor data for the car body cleaning stations. The AI experts are confident that once the pilot project at the parent plant in Munich has been completed, it will be possible to launch dust particle analysis also at other vehicle plants.

See the article here:
BMW is using Artificial Intelligence to paint its cars for a perfect result - Hindustan Times

May 22, 2020

Two University of Manitoba researchers have received support from Atomwise, the leader in using artificial intelligence (AI) for small molecule drug discovery, to explore broad-spectrum therapies for COVID-19 and other coronaviruses.

Jorg Stetefeld: It is crucial to gain a molecular understanding of how one particularly attractive protein target, nsp12, interacts with another key protein named nsp8. Once learned, this knowledge can be used to develop both new drugs and repurpose existing ones.

Faculty of Science professor Jrg Stetefeld (chemistry), Tier-1 Canada Research Chair in Structural Biology and Biophysics, and associate professor Mark Fry (biological sciences) received support through Atomwises Artificial Intelligence Molecular Screen (AIMS) awards program, which seeks to democratize access to AI for drug discovery and enable researchers to accelerate the translation of their research into novel therapies.

The current pandemic of COVID-19 is caused by a novel virus strain of SARS-CoV-2, says Stetefeld. To develop the most efficient therapeutic strategies to counteract the SARS-CoV-2 infection, it is crucial to gain a molecular understanding of how one particularly attractive protein target, nsp12, interacts with another key protein named nsp8. Once learned, this knowledge can be used to develop both new drugs and repurpose existing ones.

Professro Ben Bailey-Elkin, from the Stetefeld laboratory, will test compounds that Atomwises AI team sends him after they perform an in silico screen of millions of compounds, and carry out the subsequent biochemical and biophysical characterization, significantly reducing the time it would traditionally take to carry out this process. The Atomwise team will use their proprietary AI software to search for promising direct-acting antivirals, which interfere with the function of the viruss targeted proteins.

Professor Frys laboratory will take advantage of Atomwises cutting edge AI to screen a panel of small molecules predicted to interfere with the cellular signaling pathway that is central to the cytokine storm associated with the development of the COVID-19 acute respiratory distress syndrome.

Professor Frys laboratory will take advantage of Atomwises cutting edge AI to screen a panel of small molecules predicted to interfere with the cellular signaling pathway that is central to the cytokine storm.

Cytokines are a group of small proteins secreted by cells for the purpose of cell-to-cell communication, and in healthy individuals, these cytokines regulate key activities such as immunity, cell growth and tissue repair, for example, says Fry. A large number of patients with COVID-19 will develop life threatening pneumonia, accompanied by a so-called cytokine storm where the body experiences excessive or uncontrolled release of a number of these molecules.

Fry adds, The cytokine storm is thought to play a major role in the development of COVID-19, and there is some evidence that drugs which inhibit key cytokines such as interleukin-6 may reduce the severity of the disease. Its important to note that many of these inhibitors are part of a therapeutic class called biological drugs. These can be expensive to make and supply may be limited. My hope is that we can develop a small molecule inhibitor of the cytokine storm that will be easy to synthesize and available to all who need it.

Atomwises patented AI technology has been proven in hundreds of projects to discover drug leads for a wide variety of diseases said Dr. Stacie Calad-Thomson, vice president and head of Artificial Intelligence Molecular Screen (AIMS) Partnerships at Atomwise. Were hopeful that the therapies discovered will not only target this pandemic, but potential future pandemics.

Research at the University of Manitoba is partially supported by funding from the Government of Canada Research Support Fund.

UM Today Staff

Visit link:
UM partners with artificial intelligence leader Atomwise to pursue COVID-19 therapies - UM Today

Authored by Amit Aggarwal, co-founder and Director, Effectual Services

Every year with the growth in new technologies and inventions there have been an astounding growth in volume of intellectual property literature. Internationally, this data has to be gathered, stored, and classified in multiple formats and languages so that it can be used as and when required. However, data alone does not create a competitive advantage, extracting significant and actionable information from this data deluge represents a major challenge and an opportunity at the same time. Analysing patent documents from the pile of data manually is getting out of question day by day as it demands extensive time and resources. So, the examiners and patent analyst need all available tools at their disposal to perform this tedious task. One of the tools with a tremendous potential is Artificial Intelligence (AI). At its core, artificial intelligence is a computer that has been programmed to mimic the natural intelligence of human beings by learning, reasoning and making decisions.

From the days of fully constructed Boolean searches, search and analytics have evolved, thanks to AI-based semantic search algorithms to provide more efficient and accurate search result than ever before. A major advantage of artificial intelligence is its ability to provide repeated results as these systems are not hindered by inexperience or fatigue. Artificial intelligence tools have potential to significantly streamline and automate the patent search process and the increase the quality and speed of theobtaining results by reducing the amount of time examiners and analyst spend researching, for example,a prior art research project that can runs into days and weeks, can be performed by an AI tool in a matter of hours. Some existing tools, that are really advanced, also incorporate natural language based input that permitsa searcher to include natural language terms that can be comprehended by the backend artificial intelligence engine, which recovers comparable documents available in different languages.

The European Patent Office (EPO) uses Intelligent machine translation tool Patent Translate to allow for translation of patent publications from 32 languages into the EPO official languages of English, French and German. The US patent office (USPTO)uses artificial intelligence to help examiners to review pending patent applications by augmenting classification and searches currently a high priority with it. The UK patent office (UKIPO) also uses artificial intelligence solutions for prior art searching. IBM is offering Watson, an IP advisor that leverages artificial intelligence for fast patent ingestion, better insights, and analytics. Turbopatent, a company that develops applications to automate and streamline the patent protection process, has introduced two artificial intelligence products for patent lawyers. Roboreview, a cloud-based product that analyses drafted patent applications and rapid response, a product that assists lawyers in writing responses to office actions.

Many key players in the industry like PatSeer, Questel, have been using artificial intelligence in combination with machine learning & semantic-based algorithms to provide patent analytics tools and software.With the help of these tools and software we can now:

There are some opposing views relating to the implementation and benefit of artificial intelligence tools and techniques there are people who are concerned about the peculiarities of language used within patent documents, and doubt that how these tools can deal with the inherent ambiguities i.e.its lack of human reasoning as it is unable to carry out a sanity check of results or inventions and lacks the experience that leads to a persons intuitive response to situations.There have been some recorded incidents where the AI based tools failed to perform what it was intended to do.

All in all, its difficult to say whether the AI based tools will be able to completely mimic the human beings and perform same level of analysis or whether they will only reach to the extent of an additional help to a patent searcher we will see in coming times.

If you have an interesting article / experience / case study to share, please get in touch with us at [emailprotected]

Read more from the original source:
Importance and Benefits of Artificial intelligence for Patent Searching - Express Computer